CN113975630A - Miniature medical equipment - Google Patents
Miniature medical equipment Download PDFInfo
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- CN113975630A CN113975630A CN202111260064.1A CN202111260064A CN113975630A CN 113975630 A CN113975630 A CN 113975630A CN 202111260064 A CN202111260064 A CN 202111260064A CN 113975630 A CN113975630 A CN 113975630A
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- negative electrode
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- titanium oxide
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- 239000002131 composite material Substances 0.000 claims abstract description 16
- SWAIALBIBWIKKQ-UHFFFAOYSA-N lithium titanium Chemical compound [Li].[Ti] SWAIALBIBWIKKQ-UHFFFAOYSA-N 0.000 claims abstract description 9
- OGIDPMRJRNCKJF-UHFFFAOYSA-N titanium oxide Inorganic materials [Ti]=O OGIDPMRJRNCKJF-UHFFFAOYSA-N 0.000 claims abstract description 9
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 43
- 229910021389 graphene Inorganic materials 0.000 claims description 38
- 239000002245 particle Substances 0.000 claims description 31
- FDLZQPXZHIFURF-UHFFFAOYSA-N [O-2].[Ti+4].[Li+] Chemical compound [O-2].[Ti+4].[Li+] FDLZQPXZHIFURF-UHFFFAOYSA-N 0.000 claims description 21
- 210000001361 achilles tendon Anatomy 0.000 claims description 16
- 210000002027 skeletal muscle Anatomy 0.000 claims description 12
- 230000009471 action Effects 0.000 claims description 11
- 239000007773 negative electrode material Substances 0.000 claims description 9
- 239000007774 positive electrode material Substances 0.000 claims description 8
- 229910003002 lithium salt Inorganic materials 0.000 claims description 6
- 159000000002 lithium salts Chemical class 0.000 claims description 6
- 239000003960 organic solvent Substances 0.000 claims description 6
- -1 polypropylene Polymers 0.000 claims description 6
- QHGJSLXSVXVKHZ-UHFFFAOYSA-N dilithium;dioxido(dioxo)manganese Chemical compound [Li+].[Li+].[O-][Mn]([O-])(=O)=O QHGJSLXSVXVKHZ-UHFFFAOYSA-N 0.000 claims description 5
- 239000003792 electrolyte Substances 0.000 claims description 4
- KMTRUDSVKNLOMY-UHFFFAOYSA-N Ethylene carbonate Chemical compound O=C1OCCO1 KMTRUDSVKNLOMY-UHFFFAOYSA-N 0.000 claims description 3
- 239000004698 Polyethylene Substances 0.000 claims description 3
- 239000004743 Polypropylene Substances 0.000 claims description 3
- 239000011230 binding agent Substances 0.000 claims description 3
- 239000006258 conductive agent Substances 0.000 claims description 3
- JBTWLSYIZRCDFO-UHFFFAOYSA-N ethyl methyl carbonate Chemical compound CCOC(=O)OC JBTWLSYIZRCDFO-UHFFFAOYSA-N 0.000 claims description 3
- 229920000573 polyethylene Polymers 0.000 claims description 3
- 229920001155 polypropylene Polymers 0.000 claims description 3
- RUOJZAUFBMNUDX-UHFFFAOYSA-N propylene carbonate Chemical compound CC1COC(=O)O1 RUOJZAUFBMNUDX-UHFFFAOYSA-N 0.000 claims description 3
- 239000007787 solid Substances 0.000 claims description 3
- 230000002093 peripheral effect Effects 0.000 claims 1
- 210000003205 muscle Anatomy 0.000 abstract description 6
- 230000000694 effects Effects 0.000 abstract description 3
- 239000007772 electrode material Substances 0.000 abstract description 3
- 230000002708 enhancing effect Effects 0.000 abstract description 3
- 238000012423 maintenance Methods 0.000 abstract description 3
- 239000002243 precursor Substances 0.000 description 12
- KRHYYFGTRYWZRS-UHFFFAOYSA-N Fluorane Chemical compound F KRHYYFGTRYWZRS-UHFFFAOYSA-N 0.000 description 8
- 238000001035 drying Methods 0.000 description 7
- 238000003756 stirring Methods 0.000 description 7
- 238000010586 diagram Methods 0.000 description 6
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 5
- 230000000638 stimulation Effects 0.000 description 5
- 238000005530 etching Methods 0.000 description 4
- 238000001914 filtration Methods 0.000 description 4
- 229910002804 graphite Inorganic materials 0.000 description 4
- 239000010439 graphite Substances 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- QAOWNCQODCNURD-UHFFFAOYSA-N sulfuric acid Substances OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 4
- 239000007864 aqueous solution Substances 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- SECXISVLQFMRJM-UHFFFAOYSA-N N-Methylpyrrolidone Chemical compound CN1CCCC1=O SECXISVLQFMRJM-UHFFFAOYSA-N 0.000 description 2
- 229910001069 Ti alloy Inorganic materials 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 238000004140 cleaning Methods 0.000 description 2
- 239000011248 coating agent Substances 0.000 description 2
- 238000000576 coating method Methods 0.000 description 2
- 239000004020 conductor Substances 0.000 description 2
- 238000010790 dilution Methods 0.000 description 2
- 239000012895 dilution Substances 0.000 description 2
- 239000006185 dispersion Substances 0.000 description 2
- 239000011267 electrode slurry Substances 0.000 description 2
- 239000010408 film Substances 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- VNWKTOKETHGBQD-UHFFFAOYSA-N methane Chemical compound C VNWKTOKETHGBQD-UHFFFAOYSA-N 0.000 description 2
- 239000011268 mixed slurry Substances 0.000 description 2
- 239000002861 polymer material Substances 0.000 description 2
- 239000012286 potassium permanganate Substances 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 239000010409 thin film Substances 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- FGUUSXIOTUKUDN-IBGZPJMESA-N C1(=CC=CC=C1)N1C2=C(NC([C@H](C1)NC=1OC(=NN=1)C1=CC=CC=C1)=O)C=CC=C2 Chemical compound C1(=CC=CC=C1)N1C2=C(NC([C@H](C1)NC=1OC(=NN=1)C1=CC=CC=C1)=O)C=CC=C2 FGUUSXIOTUKUDN-IBGZPJMESA-N 0.000 description 1
- 208000034656 Contusions Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- 206010043255 Tendonitis Diseases 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 239000003462 bioceramic Substances 0.000 description 1
- 239000012620 biological material Substances 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 239000000919 ceramic Substances 0.000 description 1
- 230000009519 contusion Effects 0.000 description 1
- 239000008367 deionised water Substances 0.000 description 1
- 229910021641 deionized water Inorganic materials 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 239000011888 foil Substances 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000007769 metal material Substances 0.000 description 1
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- 239000000203 mixture Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000004118 muscle contraction Effects 0.000 description 1
- 239000012811 non-conductive material Substances 0.000 description 1
- 238000000554 physical therapy Methods 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 239000004065 semiconductor Substances 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- 238000002791 soaking Methods 0.000 description 1
- 239000012798 spherical particle Substances 0.000 description 1
- 210000002435 tendon Anatomy 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 238000009210 therapy by ultrasound Methods 0.000 description 1
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Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/36003—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation of motor muscles, e.g. for walking assistance
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/372—Arrangements in connection with the implantation of stimulators
- A61N1/378—Electrical supply
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
- Y02E60/00—Enabling technologies; Technologies with a potential or indirect contribution to GHG emissions mitigation
- Y02E60/10—Energy storage using batteries
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Battery Electrode And Active Subsutance (AREA)
Abstract
The invention provides a micro medical device, the angle formed by a rotating sheet of the device can be adjusted, so the position of an electrode can be adjusted, the electrode can stimulate more muscle parts, thereby enhancing the treatment effect, the specific energy of the battery electrode is increased to a great extent by selecting the lithium titanium oxide-graphene-lithium titanium oxide composite material of the battery electrode material, and meanwhile, the micro medical device has stable electric conduction and electric output performance, can keep higher capacity maintenance rate under the condition of high-power operation, and greatly improves the service life, stability and safety of the whole device.
Description
[ technical field ] A method for producing a semiconductor device
The invention relates to the technical field of medical equipment, in particular to miniature medical equipment.
[ background of the invention ]
The Achilles tendon is composed of ribbon tendon fibers connecting the muscle group behind the lower leg and the Achilles bone, tension is transmitted to the Achilles tendon through muscle contraction, the cross section of the Achilles tendon is much smaller than that of muscle tissue, unit tension borne by the Achilles tendon is far higher than that of the muscle tissue, and strain, fine contusion or tearing can occur when the Achilles tendon bears excessive pressure in a short time, so aseptic inflammation of the Achilles tendon occurs. Physical therapy is one of the most effective methods for treating achilles tendonitis, and electrical stimulation therapy is most effective, and the soleus muscles are stimulated by micro-current to relax and relax the achilles tendon.
[ summary of the invention ]
In view of this, the embodiment of the present invention provides a micro medical device.
A miniature medical device comprises an action component implanted at the joint of an achilles tendon and a soleus muscle and an external terminal;
the action assembly at least comprises:
the fixing seat comprises a shaft part and a fixing part, and the fixing part is fixed at the connecting part of the achilles tendon and the soleus muscle through a gripper arranged at the periphery of the bottom of the fixing part;
the rotating piece comprises a first rotating piece and a second rotating piece which are in rotating fit with the shaft part, and the first rotating piece and the second rotating piece are respectively driven by a first micro driver and a second micro driver so as to control the angle formed by the first rotating piece and the second rotating piece;
the electrode comprises a positive electrode and a negative electrode, the positive electrode is distributed at the end part of the first rotating sheet, and the negative electrode is distributed at the end part of the second rotating sheet;
the positive electrode and the negative electrode of the battery are respectively connected with the positive electrode and the negative electrode, and the battery is simultaneously used for supplying power to the whole active component;
the controller is electrically connected with the first micro driver and the second micro driver and used for receiving a control signal of an external terminal to adjust the angles of the first rotating sheet and the second rotating sheet; the controller is electrically connected with the positive electrode and the negative electrode and is used for receiving a control signal of an external terminal to control the on-off of current between the positive electrode and the negative electrode;
the external terminal includes at least:
the receiving module is used for receiving the input of control information of an operator;
the processing module is used for processing the control information and generating a corresponding control signal;
and the sending module is used for sending the control signal to the controller of the action assembly.
Preferably, the upper side and the lower side of the root of the first rotating plate are provided with first shaft sleeves which are sleeved on the upper side and the lower side of the shaft portion, the root of the second rotating plate is provided with a second shaft sleeve which is sleeved on the middle position of the shaft portion, the second shaft sleeve is positioned between the two first shaft sleeves, the driving rotor of the first micro-driver is connected with the first shaft sleeve to drive the first rotating plate to rotate, and the driving rotor of the second micro-driver is connected with the second shaft sleeve to drive the second rotating plate to rotate.
Preferably, the fixing part of the fixing base is of a solid structure, and the fixing part is fixed at the connecting part of the achilles tendon and the soleus muscle through a hand grip arranged at the periphery of the bottom of the fixing part and is fixed at the target part through a fixing nail.
Preferably, the apparatus further comprises: the shaft seat of the fixing seat is of a hollow structure, and the first micro driver, the second micro driver, the battery and the controller are integrated inside the shaft seat.
Preferably, the first and second micro-drivers may be micro-stepping motors.
Preferably, the battery comprises a positive electrode, a negative electrode and a diaphragm, wherein the diaphragm is positioned between the positive electrode and the negative electrode, the negative electrode comprises a negative electrode current collector, the surface of the negative electrode current collector is coated with a negative electrode material, the positive electrode comprises a positive electrode current collector, and the surface of the positive electrode current collector is coated with a positive electrode material; the negative electrode material is a lithium titanium oxide-graphene-lithium titanium oxide composite material which is a particle structure formed by gathering a plurality of hammer-shaped structures on a graphene connector, the hammer head part of each hammer-shaped structure is spherical lithium titanium oxide particles, graphene thin layers distributed on the surfaces of the lithium titanium oxide particles form a graphene conductive network, the hammer handle of each hammer-shaped structure is a graphene rod, the root part of each graphene rod is connected with the graphene connector, the maximum diameter of the cross section of each graphene rod is smaller than the particle size of the lithium titanium oxide particles, and the maximum diameter of the cross section of each graphene connector is smaller than the particle size of the lithium titanium oxide particles; the positive electrode material comprises lithium manganate, a conductive agent and a binder; the diaphragm is a polypropylene/polyethylene composite film; the electrolyte comprises an organic solvent and a lithium salt, wherein the mass ratio of each component of the organic solvent is that ethylene carbonate: propylene carbonate: ethyl methyl carbonate 1:1:1, lithium salt is lithium hexafluorophosphate with concentration of 1M.
Preferably, the particle size of the lithium titanium oxide particles is 100-500nm, the thickness of the graphene thin layer is 5-20nm, and the maximum cross-sectional dimension of the graphene connector is 50-300 nm.
One of the above technical solutions has the following beneficial effects:
the invention provides a micro medical device, the angle formed by a rotating sheet of the device can be adjusted, so the position of an electrode can be adjusted, the electrode can stimulate more muscle parts, thereby enhancing the treatment effect, the selection of the lithium titanium oxide-graphene-lithium titanium oxide composite material of the battery electrode material also increases the specific energy of the battery electrode to a great extent, and simultaneously has stable electric conduction and electric output performance, and can keep higher capacity maintenance rate under the condition of high-power operation, so the service life, the stability and the safety of the whole device are greatly improved.
[ description of the drawings ]
In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the drawings needed to be used in the embodiments will be briefly described below, and it is obvious that the drawings in the following description are only some embodiments of the present invention, and it is obvious for those skilled in the art to obtain other drawings based on these drawings without inventive labor.
FIG. 1 is a schematic structural diagram of a miniature medical device according to an embodiment of the present invention;
fig. 2 is a schematic structural view of a lithium titanium oxide-graphene-lithium titanium oxide composite material according to an embodiment of the present invention;
FIG. 3 is a schematic circuit diagram of a miniature medical device according to an embodiment of the present invention;
fig. 4 is a block diagram of an external terminal according to an embodiment of the present invention.
[ detailed description ] embodiments
For better understanding of the technical solutions of the present invention, the following detailed descriptions of the embodiments of the present invention are provided with reference to the accompanying drawings.
It should be understood that the described embodiments are only some embodiments of the invention, and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
The terminology used in the embodiments of the invention is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention. As used in the examples of the present invention and the appended claims, the singular forms "a," "an," and "the" are intended to include the plural forms as well, unless the context clearly indicates otherwise.
It should be understood that the term "and/or" as used herein is merely one type of association that describes an associated object, meaning that three relationships may exist, e.g., a and/or B may mean: a exists alone, A and B exist simultaneously, and B exists alone. In addition, the character "/" herein generally indicates that the former and latter related objects are in an "or" relationship.
FIG. 1 is a schematic structural diagram of a miniature medical device according to an embodiment of the present invention; fig. 2 is a schematic structural view of a lithium titanium oxide-graphene-lithium titanium oxide composite material according to an embodiment of the present invention; FIG. 3 is a schematic circuit diagram of a miniature medical device according to an embodiment of the present invention; fig. 4 is a block diagram of an external terminal according to an embodiment of the present invention.
As shown in fig. 1 to 4, an embodiment of the present invention provides a device of a micro-medical apparatus, including an action assembly 100 implanted at a connecting portion of an achilles tendon and a soleus muscle, the action assembly 100 including at least:
the fixing seat 1 comprises a shaft part 11 and a fixing part 12, wherein the fixing part 12 is fixed at the connecting part of the achilles tendon and the soleus muscle through a hand grip 121 arranged at the periphery of the bottom of the fixing part;
the rotating sheet 2, the rotating sheet 2 includes a first rotating sheet 21 and a second rotating sheet 22 which are rotatably matched with the shaft part 11, the first rotating sheet 21 and the second rotating sheet 22 are respectively driven by a first micro driver 31 and a second micro driver 32 to control the angle formed by the first rotating sheet 21 and the second rotating sheet 22;
the electrode 4, the electrode 4 includes positive electrode 41 and negative electrode 42, the positive electrode 41 is distributed on the end of the first rotating sheet 21, the negative electrode 42 is distributed on the end of the second rotating sheet 21;
and a battery 5, wherein the positive electrode and the negative electrode of the battery are respectively connected with the positive electrode and the negative electrode, and the battery is simultaneously used for supplying power to the whole active component.
It should be noted that the rotating blade part of the acting component has a definite relative movement, and the electrode at the end of the rotating blade generates a relative movement, so that the part of the electric stimulation is changed. The action component needs to be implanted into a human body, so the whole external material can be selected from biomedical metal materials, biomedical polymer materials with plasticity, biomedical polymer materials or biological ceramics, biological composite materials and the like. If the bulk exterior material is a non-conductive material (e.g., a bioceramic), the electrode portion needs to be coated with a conductive material (e.g., a titanium alloy), and if the bulk exterior material is a conductive material (e.g., a titanium alloy), the electrode portion needs to be coated with an insulating biomaterial (e.g., silica gel) at other locations except the electrode portion.
The first and second rotating pieces 21 and 22 are both arc-shaped and adapted to the contour of the soleus muscle.
Because the soleus muscle is of a curved surface structure, the first rotating piece and the second rotating piece are both arranged to be arc-shaped, positive and negative electrodes at the end parts of the first rotating piece and the second rotating piece are disc-shaped, and a plurality of conductive stimulation tips are distributed on the surface of the disc-shaped electrode.
The upper side and the lower side of the root of the first rotating piece 21 are provided with first shaft sleeves which are sleeved on the upper side and the lower side of the shaft part, the root of the second rotating piece 22 is provided with a second shaft sleeve which is sleeved on the middle position of the shaft part, and the second shaft sleeve is positioned between the two first shaft sleeves.
The fixing part of the fixing seat is of a solid structure, is fixed at the connecting part of the achilles tendon and the soleus muscle through a gripper arranged at the periphery of the bottom of the fixing part, and is fixed at a target part through a fixing nail; the shaft seat of the fixing seat is of a hollow structure, the first micro driver, the second micro driver, the battery and the controller are integrated inside the shaft seat, and the battery and the controller can be integrated outside the fixing seat under the condition of need. The first micro driver and the second micro driver can adopt micro stepping motors, a driving rotor of the first micro driver is connected with the first shaft sleeve to drive the first rotating piece to rotate, and a driving rotor of the second micro driver is connected with the second shaft sleeve to drive the second rotating piece to rotate.
Further, the action assembly of the present embodiment further includes:
the controller 6 is electrically connected with the first micro driver and the second micro driver and used for receiving a control signal of an external terminal to adjust the angles of the first rotating sheet and the second rotating sheet; the controller is electrically connected with the positive electrode and the negative electrode and is used for receiving a control signal of an external terminal to control the on-off of current between the positive electrode and the negative electrode.
The controller is used for receiving and recognizing the control signal sent by the external terminal and controlling the opening and closing of the action component, the part of the electric stimulation, the strength of the electric stimulation and the like based on the corresponding control signal.
It should be noted that the apparatus of this embodiment further includes: an external terminal 200 including at least:
a receiving module 201 for receiving an input of control information of an operator;
the processing module 202 processes the control information and generates a corresponding control signal;
and the sending module 203 sends the control signal to the controller of the action component.
Control information includes, but is not limited to: switch information, electrostimulation site information, current intensity.
Specifically, the battery comprises a positive electrode, a negative electrode and a diaphragm, wherein the diaphragm is positioned between the positive electrode and the negative electrode, the negative electrode comprises a negative electrode current collector, the surface of the negative electrode current collector is coated with a negative electrode material, the positive electrode comprises a positive electrode current collector, and the surface of the positive electrode current collector is coated with a positive electrode material; the negative electrode material is a lithium titanium oxide-graphene-lithium titanium oxide composite material, the composite material is a particle structure formed by gathering a plurality of hammer-shaped structures on a graphene connector, the hammer head part of each hammer-shaped structure is spherical lithium titanium oxide particles, a graphene thin layer distributed on the surface of each lithium titanium oxide particle forms a graphene conductive network 1000, the hammer handle of each hammer-shaped structure is a graphene rod 2000, the root of each graphene rod is connected with a graphene connector 3000 in a crossing mode, the maximum diameter of the cross section of each graphene rod is smaller than the particle size of each lithium titanium oxide particle, and the maximum diameter of the cross section of each graphene connector is smaller than the particle size of each lithium titanium oxide particle; the positive electrode material comprises lithium manganate, a conductive agent and a binder; the diaphragm is a polypropylene/polyethylene composite film; the electrolyte comprises an organic solvent and a lithium salt, wherein the mass ratio of each component of the organic solvent is that ethylene carbonate: propylene carbonate: ethyl methyl carbonate 1:1:1, lithium salt is lithium hexafluorophosphate with concentration of 1M.
The particle size of the lithium titanium oxide particles is 100-500nm, the thickness of the graphene thin layer is 5-20nm, and the maximum cross-sectional size of the graphene connector is 50-300 nm.
The thin film battery of this example was prepared by the following steps:
a. preparing lithium titanium oxide particles, the lithium titanium oxide having a spherical particle shape;
b. concentrated sulfuric acid (80% pure H by mass) is added into a reaction kettle2SO4Aqueous solution), then adding artificial flake graphite, wherein the total adding amount of the artificial flake graphite is 1/3 of concentrated sulfuric acid by mass; uniformly stirring at the temperature lower than 0 ℃, slowly dropping hydrogen peroxide at a constant speed, wherein the total adding amount of the hydrogen peroxide is 1/6 mass of concentrated sulfuric acid by mass, the adding time is 2 hours, and then continuously stirring for 2 hours; then heating in water bath, continuously stirring for 2h after the temperature is raised to 50 ℃, slowly dripping deionized water at a constant speed for dilution until the volume of the mixed solution is 2 times of that before dilution, and fully stirring; then adding potassium permanganate, wherein the total amount of potassium permanganate added is 1/9 mass of concentrated sulfuric acid by mass, fully and uniformly stirring, filtering and drying to obtain graphene oxide powder, and adding the graphene oxide powder into acetone to be uniformly dispersed by ultrasonic to obtain graphene oxide dispersion liquid;
c. adding the lithium titanium oxide particles obtained in the step a into the graphene oxide dispersion liquid obtained in the step b, fully and uniformly stirring to obtain mixed slurry, wherein the mass ratio of the lithium titanium oxide to the graphene oxide in the mixed slurry is 1:6, filtering, drying in a drying oven at the temperature of 70 ℃ to obtain a precursor of the lithium titanium oxide/graphene oxide composite material, adding a hydrofluoric acid aqueous solution with the mass concentration of 15% into the precursor, carrying out primary etching for 2 hours, cleaning an etching product, removing hydrofluoric acid on the surface of the product, filtering, and drying to obtain a composite material precursor product after the primary etching;
d. c, adding the precursor product obtained in the step c into ethanol for ultrasonic dispersion treatment, wherein the ultrasonic treatment time is 2 hours, the ultrasonic frequency is 100KHz, and filtering and drying to obtain a powdery precursor;
e. d, adding the powdery precursor obtained in the step d into N-methyl pyrrolidone which is 3 times of the mass of the precursor powder, and stirring to uniformly mix the precursor powder and the N-methyl pyrrolidone to obtain negative electrode slurry;
f. coating the negative electrode slurry obtained in the step e on an aluminum foil serving as a negative electrode current collector, drying for 4h at the temperature of 65 ℃, then carrying out heat treatment for 20h at the temperature of 180 ℃ under a vacuum condition, reducing graphite oxide into graphene with a porous cross-linked structure, coating the graphene on the surfaces of lithium titanium oxide particles, and forming the graphene into a particle structure formed by gathering a plurality of hammer-shaped structures on a graphene connector by adopting a template method, so as to obtain a negative electrode precursor coated with a negative electrode material on the surface of the negative electrode current collector;
g. soaking the negative electrode precursor obtained in the step f in a hydrofluoric acid aqueous solution with the mass concentration of 20%, performing secondary etching for 4 hours, taking out the negative electrode precursor, cleaning to remove the hydrofluoric acid on the surface of the negative electrode precursor, and drying for 8 hours at 65 ℃ under a vacuum condition to obtain a negative electrode with the surface of a negative electrode current collector coated with a negative electrode material layer, wherein the negative electrode material is the lithium titanium oxide-graphene-lithium titanium oxide composite material;
h. preparing a positive electrode by taking lithium manganate as a positive electrode active material;
i. and forming an electrode assembly by using a stacking structure of a negative electrode/a diaphragm/a positive electrode/a diaphragm/a negative electrode, putting the electrode assembly into a shell, injecting electrolyte and sealing to form a battery preformed body, and after a battery preformed body is subjected to a formation process, carrying out capacity grading and matching to obtain the thin-film secondary battery, wherein the stacking number of the electrodes of the stacking structure can be adjusted according to the output power of the battery.
The differences in capacity retention and safety between the battery of this example and the battery of the prior art are compared by table 1 below. The experimental group adopts the battery of the embodiment of the invention, the comparison group adopts graphite carbon powder as an active substance and PEO as an adhesive to prepare a negative electrode, and adopts lithium manganate as a positive electrode active material to prepare a positive electrode, and other steps are completely the same as the steps of the embodiment of the invention.
TABLE 1
The technical scheme of the embodiment of the invention has the following beneficial effects:
the invention provides a micro medical device, the angle formed by a rotating sheet of the device can be adjusted, so the position of an electrode can be adjusted, the electrode can stimulate more muscle parts, thereby enhancing the treatment effect, the specific energy of the battery electrode is increased to a great extent by selecting the lithium titanium oxide-graphene-lithium titanium oxide composite material of the battery electrode material, and meanwhile, the micro medical device has stable electric conduction and electric output performance, can keep higher capacity maintenance rate under the condition of high-power operation, and greatly improves the service life, stability and safety of the whole device.
The above description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the invention, and any modifications, equivalents, improvements and the like made within the spirit and principle of the present invention should be included in the scope of the present invention.
Claims (7)
1. A miniature medical device comprising an active component implanted at the junction of the achilles tendon and the soleus muscle, and an external terminal;
the action assembly at least comprises:
the fixing seat comprises a shaft part and a fixing part, and the fixing part is fixed at the connecting part of the achilles tendon and the soleus muscle through a gripper arranged at the periphery of the bottom of the fixing part;
the rotating piece comprises a first rotating piece and a second rotating piece which are in rotating fit with the shaft part, and the first rotating piece and the second rotating piece are respectively driven by a first micro driver and a second micro driver so as to control the angle formed by the first rotating piece and the second rotating piece;
the electrode comprises a positive electrode and a negative electrode, the positive electrode is distributed at the end part of the first rotating sheet, and the negative electrode is distributed at the end part of the second rotating sheet;
the positive electrode and the negative electrode of the battery are respectively connected with the positive electrode and the negative electrode, and the battery is simultaneously used for supplying power to the whole active component;
the controller is electrically connected with the first micro driver and the second micro driver and used for receiving a control signal of an external terminal to adjust the angles of the first rotating sheet and the second rotating sheet; the controller is electrically connected with the positive electrode and the negative electrode and is used for receiving a control signal of an external terminal to control the on-off of current between the positive electrode and the negative electrode;
the external terminal includes at least:
the receiving module is used for receiving the input of control information of an operator;
the processing module is used for processing the control information and generating a corresponding control signal;
and the sending module is used for sending the control signal to the controller of the action assembly.
2. The micro medical device as claimed in claim 1, wherein the first rotor has first shaft sleeves at upper and lower sides of the root portion, the second rotor has a second shaft sleeve at a middle position of the shaft portion, the second shaft sleeve is located between the first shaft sleeves, the first micro driver has a driving rotor connected to the first shaft sleeve for driving the first rotor to rotate, and the second micro driver has a driving rotor connected to the second shaft sleeve for driving the second rotor to rotate.
3. The micro medical device of claim 2, wherein the fixing portion of the fixing base is a solid structure, and the fixing portion is fixed to the connecting portion of the achilles tendon and the soleus muscle by a grip provided at a bottom peripheral edge of the fixing portion and fixed to the target portion by a fixing nail.
4. The biomedical device according to claim 3, wherein the shaft seat of the holder is hollow, and the first microdrive, the second microdrive, the battery and the controller are integrated inside the shaft seat.
5. The micro medical device of claim 4, wherein the first and second micro drivers are optionally micro stepper motors.
6. The micro medical device according to claim 5, wherein the battery comprises a positive electrode, a negative electrode, and a separator, the separator being positioned between the positive electrode and the negative electrode, the negative electrode comprising a negative electrode current collector, the negative electrode current collector being coated with a negative electrode material on a surface thereof, the positive electrode comprising a positive electrode current collector, the positive electrode current collector being coated with a positive electrode material on a surface thereof; the negative electrode material is a lithium titanium oxide-graphene-lithium titanium oxide composite material which is a particle structure formed by gathering a plurality of hammer-shaped structures on a graphene connector, the hammer head part of each hammer-shaped structure is spherical lithium titanium oxide particles, graphene thin layers distributed on the surfaces of the lithium titanium oxide particles form a graphene conductive network, the hammer handle of each hammer-shaped structure is a graphene rod, the root part of each graphene rod is connected with the graphene connector, the maximum diameter of the cross section of each graphene rod is smaller than the particle size of the lithium titanium oxide particles, and the maximum diameter of the cross section of each graphene connector is smaller than the particle size of the lithium titanium oxide particles; the positive electrode material comprises lithium manganate, a conductive agent and a binder; the diaphragm is a polypropylene/polyethylene composite film; the electrolyte comprises an organic solvent and a lithium salt, wherein the mass ratio of each component of the organic solvent is that ethylene carbonate: propylene carbonate: ethyl methyl carbonate 1:1:1, lithium salt is lithium hexafluorophosphate with concentration of 1M.
7. The biomedical device according to claim 6, wherein the lithium titanium oxide particles have a particle size of 100-500nm, the thickness of the graphene thin layer is 5-20nm, and the maximum cross-sectional dimension of the graphene connector is 50-300 nm.
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Citations (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3026007B1 (en) * | 1999-03-29 | 2000-03-27 | 学校法人 久留米大学 | Muscle strengthener |
| US6341237B1 (en) * | 1999-10-25 | 2002-01-22 | Arthur F. Hurtado | Device for administrating electro-muscle stimulation and method of use |
| CN1678368A (en) * | 2002-08-26 | 2005-10-05 | 阿瑟·F·赫泰德 | Method and system for applying variable electrical muscle stimulation |
| CN101495175A (en) * | 2006-05-22 | 2009-07-29 | 帝国生物医学设备公司 | Method and device for enhanced blood flow |
| CN101593846A (en) * | 2009-06-30 | 2009-12-02 | 东莞市天球实业有限公司 | A kind of high-power high-energy iron phosphate lithium battery and preparation method thereof |
| KR20100024265A (en) * | 2008-08-25 | 2010-03-05 | 최상식 | Brace having function of stimulating deep muscle electrically |
| CN102468485A (en) * | 2010-11-04 | 2012-05-23 | 海洋王照明科技股份有限公司 | Lithium titanate composite material, preparation method and application thereof |
| JP2013500080A (en) * | 2009-07-23 | 2013-01-07 | エムキネティクス， インコーポレイテッド | Cooling system and method for conductive coils |
| CN103103628A (en) * | 2013-01-14 | 2013-05-15 | 北京大学深圳研究生院 | Nano material and application thereof, and method and device for preparing nano material |
| CN103169472A (en) * | 2013-04-09 | 2013-06-26 | 重庆绿色智能技术研究院 | Non-invasive neuromuscular disease inspection system based on attached electrode |
| CN103893829A (en) * | 2014-03-27 | 2014-07-02 | 西安理工大学 | Preparation method of injectable porous compound bone cement |
| CN104812438A (en) * | 2012-12-07 | 2015-07-29 | 美敦力公司 | Minimally invasive implantable neurostimulation system |
| CN105536146A (en) * | 2016-02-01 | 2016-05-04 | 叶强 | Mobile intelligent multi-channel dynamic electrical stimulation lower limb walking aid and mobile intelligent multi-channel dynamic electrical stimulation lower limb walking method |
| US20160128620A1 (en) * | 2014-11-12 | 2016-05-12 | Riken | Threshold estimation apparatus, threshold estimation method, and non-transitory computer-readable information recording medium |
| CN105705195A (en) * | 2013-10-23 | 2016-06-22 | 梅恩斯塔伊医疗公司 | Systems and methods for restoring muscle function to the lumbar spine |
| US20180028821A1 (en) * | 2016-08-01 | 2018-02-01 | Biotronik Se & Co. Kg | Electromedical implant comprising an electrical feedthrough |
| US20180085573A1 (en) * | 2016-09-27 | 2018-03-29 | National Guard Health Affairs | Skull implanted electrode assembly for brain stimulation |
| CN107854774A (en) * | 2017-10-25 | 2018-03-30 | 国家康复辅具研究中心 | A kind of wireless electro photoluminescence walk help system of plantar pressure feedback driving |
| CN207222444U (en) * | 2017-09-19 | 2018-04-13 | 江门市宏力能源有限公司 | A kind of automatic double-sided cleaning device of battery |
| CN108926770A (en) * | 2018-07-31 | 2018-12-04 | 蚌埠科睿达机械设计有限公司 | A kind of device for treating Achilles tendinitis |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4786277A (en) * | 1986-11-21 | 1988-11-22 | Trustees Of Boston University | Electrodes, electrode assemblies, methods, and systems for tissue stimulation |
| CN101007198A (en) * | 2007-01-22 | 2007-08-01 | 周鹏 | Wrist apparatus for rapid postoperative analgesia |
| WO2009155436A1 (en) * | 2008-06-18 | 2009-12-23 | Accelerated Care Plus Corp. | Electrical stimulation method for reduction of joint compression |
-
2018
- 2018-07-31 CN CN202111260064.1A patent/CN113975630A/en active Pending
- 2018-07-31 CN CN201810858897.XA patent/CN108926770B/en active Active
Patent Citations (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3026007B1 (en) * | 1999-03-29 | 2000-03-27 | 学校法人 久留米大学 | Muscle strengthener |
| US6341237B1 (en) * | 1999-10-25 | 2002-01-22 | Arthur F. Hurtado | Device for administrating electro-muscle stimulation and method of use |
| CN1678368A (en) * | 2002-08-26 | 2005-10-05 | 阿瑟·F·赫泰德 | Method and system for applying variable electrical muscle stimulation |
| CN101495175A (en) * | 2006-05-22 | 2009-07-29 | 帝国生物医学设备公司 | Method and device for enhanced blood flow |
| KR20100024265A (en) * | 2008-08-25 | 2010-03-05 | 최상식 | Brace having function of stimulating deep muscle electrically |
| CN101593846A (en) * | 2009-06-30 | 2009-12-02 | 东莞市天球实业有限公司 | A kind of high-power high-energy iron phosphate lithium battery and preparation method thereof |
| JP2013500080A (en) * | 2009-07-23 | 2013-01-07 | エムキネティクス， インコーポレイテッド | Cooling system and method for conductive coils |
| CN102468485A (en) * | 2010-11-04 | 2012-05-23 | 海洋王照明科技股份有限公司 | Lithium titanate composite material, preparation method and application thereof |
| CN104812438A (en) * | 2012-12-07 | 2015-07-29 | 美敦力公司 | Minimally invasive implantable neurostimulation system |
| CN103103628A (en) * | 2013-01-14 | 2013-05-15 | 北京大学深圳研究生院 | Nano material and application thereof, and method and device for preparing nano material |
| CN103169472A (en) * | 2013-04-09 | 2013-06-26 | 重庆绿色智能技术研究院 | Non-invasive neuromuscular disease inspection system based on attached electrode |
| CN105705195A (en) * | 2013-10-23 | 2016-06-22 | 梅恩斯塔伊医疗公司 | Systems and methods for restoring muscle function to the lumbar spine |
| CN103893829A (en) * | 2014-03-27 | 2014-07-02 | 西安理工大学 | Preparation method of injectable porous compound bone cement |
| US20160128620A1 (en) * | 2014-11-12 | 2016-05-12 | Riken | Threshold estimation apparatus, threshold estimation method, and non-transitory computer-readable information recording medium |
| CN105536146A (en) * | 2016-02-01 | 2016-05-04 | 叶强 | Mobile intelligent multi-channel dynamic electrical stimulation lower limb walking aid and mobile intelligent multi-channel dynamic electrical stimulation lower limb walking method |
| US20180028821A1 (en) * | 2016-08-01 | 2018-02-01 | Biotronik Se & Co. Kg | Electromedical implant comprising an electrical feedthrough |
| US20180085573A1 (en) * | 2016-09-27 | 2018-03-29 | National Guard Health Affairs | Skull implanted electrode assembly for brain stimulation |
| CN207222444U (en) * | 2017-09-19 | 2018-04-13 | 江门市宏力能源有限公司 | A kind of automatic double-sided cleaning device of battery |
| CN107854774A (en) * | 2017-10-25 | 2018-03-30 | 国家康复辅具研究中心 | A kind of wireless electro photoluminescence walk help system of plantar pressure feedback driving |
| CN108926770A (en) * | 2018-07-31 | 2018-12-04 | 蚌埠科睿达机械设计有限公司 | A kind of device for treating Achilles tendinitis |
Non-Patent Citations (2)
| Title |
|---|
| 杨张凯, 王学廉, 汪鑫, 等.: "脑深部电刺激治疗肌张力障碍的疗效分析", 《中国临床神经外科杂志》, vol. 20, no. 1, 31 December 2015 (2015-12-31), pages 21 - 24 * |
| 陈磊, 王学廉: "药物成瘾脑深部电刺激术研究进展", 《中国现代神经疾病杂志》, vol. 15, no. 10, 31 December 2015 (2015-12-31), pages 782 - 789 * |
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