CN113969066A

CN113969066A - Bone density radiation image equivalent material

Info

Publication number: CN113969066A
Application number: CN202010716744.9A
Authority: CN
Inventors: 孙朝阳; 孙芳
Original assignee: Gu'an Chaoyang Biological Technology Co ltd
Current assignee: Gu'an Chaoyang Biological Technology Co ltd
Priority date: 2020-07-23
Filing date: 2020-07-23
Publication date: 2022-01-25

Abstract

The invention discloses a bone density radiation image equivalent material which comprises bone cement, hydroxyapatite, water, fat powder and plastic powder, wherein the mass ratio of the bone cement to the hydroxyapatite to the water to the fat powder to the plastic powder is 1:1.2-1.5:0.2-0.4:0.6-0.8: 0.8-1.2; the preparation steps are as follows: (1) mixing the following components in percentage by weight: uniformly mixing the hydroxyapatite at normal temperature, and collecting for later use; (2) mixing fat powder: uniformly mixing the plastic powder in a low-temperature vacuum mixing device, and collecting for later use; (3) uniformly adding the uniformly mixed bone cement, hydroxyapatite, fat powder, plastic powder and water into a low-temperature vacuum mixing device, uniformly mixing, and storing at a low temperature for later use; (4) mixing the uniformly mixed bone cement: hydroxyapatite: water: fat powder: the plastic powder is printed using 3D printing technology. The invention adopts medical bone cement, Hydroxyapatite (HPA) for shaping bones and C, H, O bioequivalent organic materials with water and fat simulation components and consistent molecular structure, and the materials are prepared by a special process to become equivalent substitutes of bones.

Description

Bone density radiation image equivalent material

Technical Field

The invention relates to the field of bone mineral density materials, in particular to a bone mineral density radiation image equivalent material.

Background

In the radiographic image, the equivalence of bone density materials has important significance for bone density detectors, osteoporosis diagnosis and bone age diagnosis, but at present, equivalent materials have huge differences and are not uniform, aluminum plates, polytetrafluoroethylene and bone substitute materials self-made by some manufacturers are adopted to simulate human bones, the materials are not equivalent to the human bones, uniform detection results cannot be obtained on different machines, the detection results of bone densitometers among the manufacturers cannot be mutually recognized, and the diagnosis difference of the same patient is often huge. Becomes an important reason for the confusion of the diagnosis standard of the osteoporosis diseases. The method is characterized in that no uniform bone-like material suitable for human body equivalence is made into a standard bone density block, the measurement value of the bone density of the whole country is unified, and the performance evaluation of a bone density measuring instrument is standardized.

Other manufacturers at home and abroad adopt bone density samples prepared by mixing inorganic calcium and silicon with organic matters, but the situation that detection images cannot be interpreted frequently occurs on bone density scanners of certain brands, and even the situation that the images of the bone density samples cannot be scanned by machines is common. The bone density results obtained by the instruments capable of performing interpretation are also very different, and a unified diagnosis conclusion cannot be obtained. In particular, it should be noted that silicon is only present in stones of the human body, and the main component of the human skeleton is free from silicon, and materials which are not present in the human body cannot be adopted for the purpose of ray equivalence, which is the basic principle that the research on the radiation equivalent materials of the human body cannot be bypassed.

The technology matures in surgical applications for many years and is very close to the radiological image of real bone. However, in order for bone material to be used in surgery to grow new bone and to ensure biocompatibility, a large number of voids must be created to accommodate the growth of new bone. The density uniformity is poor and the in vitro storage conditions are harsh, so that the standard bone sample cannot be prepared. In particular, long-term in vitro storage cannot maintain various indexes such as: parameters such as bone density, uniformity, moisture and the like are unchanged. Therefore, it is necessary to develop a standard bone equivalent material which can meet the radiation imaging characteristics of human bones, can be stored for a long time, and has the stability and consistency meeting the requirements. Ensuring accurate and traceable bone mineral density value.

Disclosure of Invention

In view of the above-mentioned deficiencies or inadequacies of the prior art, it would be desirable to provide a bone density radiographic equivalent material.

According to the technical scheme provided by the embodiment of the invention, the bone density radiation image equivalent material comprises bone cement, hydroxyapatite, water, fat powder and plastic powder, wherein the mass ratio of the bone cement to the hydroxyapatite to the water to the fat powder to the plastic powder is 1:1.2-1.5:0.2-0.4:0.6-0.8: 0.8-1.2;

the preparation steps are as follows:

(1) mixing the following components in percentage by weight: uniformly mixing the hydroxyapatite at normal temperature according to the mass ratio of 1:1.2-1.5, and collecting for later use;

(2) mixing fat powder: uniformly mixing the plastic powder in a low-temperature vacuum mixing device according to the mass ratio of 0.6-0.8:0.8-1.2, and collecting for later use;

(3) uniformly adding the bone cement, the hydroxyapatite, the fat powder, the plastic powder and the water which are uniformly mixed in a low-temperature vacuum mixing device, so that the bone cement, the hydroxyapatite, the water, the fat powder and the plastic powder are added according to the mass ratio of 1:1.2-1.5:0.2-0.4:0.6-0.8:0.8-1.2, uniformly mixing and storing at low temperature for later use;

(4) mixing the uniformly mixed bone cement: hydroxyapatite: water: fat powder: the plastic powder is printed using 3D printing technology.

In the invention, the fat powder: the mixing temperature of the plastic powder is 0-10 ℃.

In the invention, the preservation temperature of the mixed bone cement, hydroxyapatite, water, fat powder and plastic powder is 0-10 ℃.

In the invention, the hydroxyapatite is sanitary powder with the fineness of 5-7 μm.

In the invention, the fat powder is vegetable fat powder, and the fat content is 60-70%.

In the present invention, the powder fineness of the plastic powder is 5 μm to 10 μm.

In conclusion, the invention has the beneficial effects that: the invention adopts medical bone cement, Hydroxyapatite (HPA) for shaping bones and C, H, O bioequivalent organic materials with water and fat simulation components and consistent molecular structure, and the materials are prepared by a special process to become equivalent substitutes of bones.

Detailed Description

The present invention will be described in further detail with reference to examples. It is to be understood that the specific embodiments described herein are merely illustrative of the relevant invention and not restrictive of the invention. It should be noted that, for convenience of description, only the portions related to the invention are shown in the embodiments.

It should be noted that the embodiments and features of the embodiments may be combined with each other without conflict. The present invention will be described in detail below with reference to examples.

The bone density radiation image equivalent material comprises bone cement, hydroxyapatite, water, fat powder and plastic powder, wherein the mass ratio of the bone cement to the hydroxyapatite to the water to the fat powder to the plastic powder is 1:1.2-1.5:0.2-0.4:0.6-0.8: 0.8-1.2; the preparation steps are as follows:

(4) mixing the uniformly mixed bone cement: hydroxyapatite: water: fat powder: the plastic powder is printed using 3D printing technology. Fat powder: the mixing temperature of the plastic powder is 0-10 ℃. The preservation temperature of the mixed bone cement, hydroxyapatite, water, fat powder and plastic powder is 0-10 ℃. The hydroxyapatite is sanitary powder with fineness of 5-7 μm. The fat powder is vegetable fat powder, and the fat content is 60-70%. The fineness of the plastic powder is 5-10 μm.

The working conditions of the low-temperature vacuum mixing device presented in the invention are: the temperature is 0-10 ℃, and the vacuum degree is-0.1 MPa-0.4 MPa.

The foregoing description is only exemplary of the preferred embodiments of the invention and is illustrative of the principles and techniques that may be employed. Meanwhile, the scope of the present invention is not limited to the specific combinations of the above-described features, and other embodiments in which the above-described features or their equivalents are arbitrarily combined without departing from the spirit of the present invention are also encompassed. For example, the above features and (but not limited to) features having similar functions disclosed in the present invention are mutually replaced to form the technical solution.

Claims

1. A bone density radiation image equivalent material is characterized in that: comprises bone cement, hydroxyapatite, water, fat powder and plastic powder, wherein the mass ratio of the bone cement to the hydroxyapatite to the water to the fat powder to the plastic powder is 1:1.2-1.5:0.2-0.4:0.6-0.8: 0.8-1.2;

the preparation steps are as follows:

2. The bone density radiograph equivalent material as set forth in claim 1, wherein: fat powder: the mixing temperature of the plastic powder is 0-10 ℃.

3. The bone density radiograph equivalent material as set forth in claim 1, wherein: the preservation temperature of the mixed bone cement, hydroxyapatite, water, fat powder and plastic powder is 0-10 ℃.

4. The bone density radiograph equivalent material as set forth in claim 1, wherein: the hydroxyapatite is sanitary powder with fineness of 5-7 μm.

5. The bone density radiograph equivalent material as set forth in claim 1, wherein: the fat powder is vegetable fat powder, and the fat content is 60-70%.

6. The bone density radiograph equivalent material as set forth in claim 1, wherein: the fineness of the plastic powder is 5-10 μm.