CN113876669B - Anti-saccharification traditional Chinese medicine composition, preparation method thereof and application thereof in cosmetic product - Google Patents
Anti-saccharification traditional Chinese medicine composition, preparation method thereof and application thereof in cosmetic product Download PDFInfo
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- CN113876669B CN113876669B CN202111357752.XA CN202111357752A CN113876669B CN 113876669 B CN113876669 B CN 113876669B CN 202111357752 A CN202111357752 A CN 202111357752A CN 113876669 B CN113876669 B CN 113876669B
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Classifications
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A61Q19/00—Preparations for care of the skin
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- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
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- A—HUMAN NECESSITIES
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- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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Abstract
The invention discloses a preparation method of a traditional Chinese medicine source composition and application of the traditional Chinese medicine source composition in preparing anti-saccharification cosmetic products. Specifically, the invention discloses a rhodiola rosea extract and dandelion extract which are prepared from 70-90% by weight: 10-30% of the formulated composition. Biochemical test shows that the composition has synergistic protein glycosylation inhibiting activity, the inhibiting activity is obviously higher than that of single extract, and the composition has very low cytotoxicity and can be used as an anti-saccharification component for preparing cosmetic products. The invention also discloses application of the composition from the traditional Chinese medicine as a cosmetic ingredient to preparation of anti-saccharification face cream.
Description
Technical Field
The invention relates to a preparation method of an anti-saccharification traditional Chinese medicine composition and application of the anti-saccharification traditional Chinese medicine composition in manufacturing beauty products, and belongs to the field of cosmetics.
Background
Brownlee in 1984 reported the presence of advanced glycation end products (AGEs) in vivo. AGEs refer to a complex class of glycosylation products produced by biological macromolecules (nucleic acids, proteins, and lipids) through non-enzymatic catalytic mechanisms. Non-enzymatically catalyzed glycosylation reactions primarily refer to a series of chemical reactions that occur between the terminal free carbonyl groups of reducing monosaccharide molecules and the free amino groups in nucleic acid, protein and lipid macromolecules (FIG. 1). Studies have found that AGEs products in vivo can be divided into three major categories: non-crosslinked non-fluorescent product, and non-crosslinked fluorescent product. More than 20 AGEs products have been identified from human blood and tissues.
AGEs are potentially toxic molecules that threaten human health. For example, glycosylation of protein molecules in vivo may result in changes in the secondary structure of the protein molecule, thereby affecting the function of the protein, until it leads to cell damage. In addition, collagen is an important tissue protein in the skin, and as the age and high-sugar eating habit increase, collagen is gradually saccharified, and the skin becomes hard and black, and finally skin aging is caused and the beauty is affected. Therefore, if the glycosylation level of biological macromolecules in the body can be effectively inhibited, the biological macromolecules can be helpful for improving some disease states, delaying aging and keeping the young state of skin. Initial studies have found that some natural products with antioxidant activity are effective in inhibiting AGEs formation, i.e., have Anti-glycation (Anti-glycation) activity. As research proceeds, researchers have found that more different classes of natural products are able to inhibit AGEs formation. Natural products with anti-glycation activity include polyphenols, polysaccharides, terpenoids, vitamins, alkaloids and polypeptides, which inhibit AGEs formation by different mechanisms.
Natural products are an important source of anti-glycation active products, and the traditional Chinese medicine extract is rich in various natural products. The traditional Chinese medicine extract obtained by screening in the earlier stage of the project group has obvious anti-saccharification activity. Considering that different types of natural products are used for resisting the formation of AGEs through different mechanisms, different traditional Chinese medicine extracts are combined, and the combination of different AGEs inhibition mechanisms is used for seeking a traditional Chinese medicine extract composition with synergistic anti-saccharification activity.
The research history of traditional Chinese medicine on beauty can be traced to thousands of years ago, and in recent years, chinese herbal medicine cosmetics are increasingly popular with consumers. The Chinese herbal medicine cosmetics adopt the guidance of Chinese medicine theory, which is also the largest difference between the Chinese herbal medicine cosmetics and other cosmetics. The beauty product containing the Chinese herbal medicines has obvious effect and high safety, and is welcomed by consumers. RHODIOLA ROSEA (RHODIOLA ROSEA) is a perennial herb. The medicinal part of rhodiola root is root, its root is strong and upright. Rhodiola rosea has the effects of tonifying qi, clearing lung, improving intelligence, nourishing heart, astringing, stopping bleeding, removing stasis and relieving swelling. Studies have reported that the roots of rhodiola rosea are rich in various essential oils (e.g., monoterpene hydrocarbons, monoterpene alcohols, linear fatty alcohols, n-decanol, geraniol), fats, waxes, sterols, glycosides, organic acids (e.g., oxalic acid, citric acid, malic acid, gallic acid, succinic acid), polyphenols (e.g., tannins), flavones, and isoflavones, and proteins. Dandelion (TARAXACUM MONGOLICUM) belongs to the family of the asteraceae and perennial herbs. The herba Taraxaci whole plant contains taraxasterol, choline, inulin, pectin, etc. Dandelion is sweet in flavor, slightly bitter and cold in nature. The dandelion extract has the effects of resisting inflammation and infectious diseases. Researchers have also isolated various polysaccharides, flavonoid glycosides, organic acids, alkaloids, fats, proteins, etc. from dandelion extracts. So far, no report on the pharmacodynamic activity of single components or compositions of dandelion extract and rhodiola rosea extract in inhibiting AGEs formation is seen.
Disclosure of Invention
The invention aims to solve the technical problem of providing a composition prepared by mixing two traditional Chinese medicine extracts, namely RHODIOLA ROSEA (RHODIOLA ROSEA) extract and dandelion (TARAXACUM MONGOLICUM) extract, and a preparation method thereof.
The invention aims to solve the technical problem, and the research discovers that compared with a single traditional Chinese medicine extract, a mixture of the rhodiola rosea extract and the dandelion extract has obviously enhanced anti-saccharification activity, and the composition has synergistic anti-saccharification activity. In addition, the rhodiola rosea extract, the dandelion extract and the mixture of the rhodiola rosea extract and the dandelion extract have low cytotoxicity.
Yet another technical problem to be solved by the present invention is that the composition of the traditional Chinese medicine extract exhibits good anti-glycation activity, and the cosmetic product, such as a face cream, is prepared using this composition of the traditional Chinese medicine as a cosmetic ingredient.
In order to solve the technical problems of the invention, the invention adopts the following technical scheme:
the first aspect of the invention relates to a composition prepared by mixing two traditional Chinese medicine extracts, namely rhodiola rosea extract and dandelion extract according to a certain proportion, and the preparation method comprises the following steps:
the composition is prepared by mixing rhodiola rosea extract and dandelion extract according to a certain weight ratio, wherein the content of the rhodiola rosea extract in the composition is more than that of the dandelion extract, and the weight percentages of the rhodiola rosea extract and the dandelion extract are as follows: dandelion extract = 70-90%:10-30%, weighing and mixing uniformly.
Further preferred compositions are prepared as follows: rhodiola rosea extract: dandelion extract = 70%: weighing and uniformly mixing 30% by weight.
In a second aspect, the present invention relates to a composition of traditional Chinese medicine origin as described above, capable of reducing the glycosylation of albumin, and in particular, in a study we compared the anti-glycation activity of two single extracts with a composition, in particular, a composition having a significantly enhanced, i.e. synergistic, anti-glycation activity, suitable as anti-glycation ingredient for the preparation of corresponding cosmetic products.
The third aspect of the invention relates to the use of the composition derived from the traditional Chinese medicine in the preparation of cosmetic products with anti-glycation activity, such as creams. And provides a specific formula of the face cream containing the traditional Chinese medicine source composition as a beautifying component and a preparation method thereof.
Drawings
Fig. 1: formation mechanism of advanced glycation end products (AGEs).
Fig. 2: anti-glycation activity studies of the different components. The four detection components are aminoguanidine, rhodiola rosea extract, dandelion extract and a preferred extract composition.
Fig. 3: anti-glycation activity IC of four components 50 . The four detection components are aminoguanidine, rhodiola rosea extract, dandelion extract and a preferred extract composition.
Detailed Description
The invention will be further illustrated with reference to specific examples. It should be understood that the detailed description and specific examples are intended for purposes of illustration only and are not intended to limit the scope of the invention.
The specific techniques or conditions are not identified in the examples and are described in the literature in this field or are carried out in accordance with the product specifications. The reagents or equipment used were conventional products available for purchase through regular channels, with no manufacturer noted.
The experimental methods in the following examples are conventional methods unless otherwise specified. The test materials used in the examples described below, unless otherwise specified, are all commercially available products.
Example 1: preparation method of traditional Chinese medicine source extract composition
RHODIOLA ROSEA (RHODIOLA ROSEA) extract, a reddish brown powder, is very soluble in water and is available from wuhan fuxin chemical company. Herba Taraxaci (TARAXACUM MONGOLICUM) extract, a yellow-brown powder, is readily soluble in water and is available from Wuhan Fuxin chemical Co. The preparation method of the composition comprises the following steps: the composition is prepared by mixing rhodiola rosea extract and dandelion extract according to a certain weight ratio, wherein the content of the rhodiola rosea extract in the composition is more than that of the dandelion extract, and the weight percentages of the rhodiola rosea extract and the dandelion extract are as follows: dandelion extract = 70-90%:10-30%, and mixing evenly after weighing.
Further, the preferred method of preparation of the composition is as follows: rhodiola rosea extract: dandelion extract = 70%: weighing and uniformly mixing 30% by weight.
In the specific operation, weighing 7g of rhodiola rosea extract, 3g of dandelion extract and uniformly mixing 10g of brown powder to obtain the composition.
Example 2: anti-glycation activity of traditional Chinese medicine source extract composition
The experimental method comprises the following steps:the inhibitory activity of rhodiola rosea extract, dandelion extract and the preferred composition prepared in experimental example 1 on AGEs formation was examined according to the anti-glycation activity study method proposed by Vinson and Howard in 1996. Samples of 0.5mL at a concentration of 10,20,50,100,200 μg/mL were added to 0.1M PBS buffer containing 0.5mL 20mg/mL BSA, 0.5mL 0.5M glucose and 1.0mL 1% sodium azide, ph=7.4. Incubation was carried out at 37℃for 7 days using a fluorescence spectrometer (EnSpireElmer, MA, USA), set the detection conditions to E x ＝330nm,E m Fluorescence Intensity (FI) of AGEs formation was measured =410 nm. No inhibitor was added to the control group. Anti-glycation reference positive compounds were compared using aminoguanidine.
The inhibitory activity on AGEs formation was calculated by the following formula:
inhibitory Activity (%) = [1- (FI sample-FI sample blank)/(FI control-FI control blank) ]. Times.100%
Calculation of IC by inhibitory Activity at different concentrations 50 Calculation was performed using software GraphPad Prism 8.0.
The results are as follows：
TABLE 1 anti-glycation Activity Studies of different Components
The experimental results are shown in table 1 and fig. 2. The rhodiola rosea extract or dandelion extract with various concentrations has a certain anti-saccharification activity, but the anti-saccharification activity is weaker than that of the positive compound aminoguanidine. For example, at a concentration of 200 μg/mL, the anti-glycation activities of rhodiola rosea extract and dandelion extract were 43% and 39%, respectively, whereas the anti-glycation inhibitory activity of aminoguanidine, a positive compound, was 78% (similar to the data reported in the literature), but the rhodiola rosea extract and dandelion extract were 70%: the preferred composition of 30% by weight has significantly improved anti-glycation inhibiting activity. As shown in FIG. 3, IC for inhibiting AGEs formation was calculated using GraphPad Prism 8.0 for the four components 50 66.21 μg/mL-aminoguanidine, 262.6 μg/mL-rhodiola rosea extract, 315.7- μg/mL dandelion extract, 48.92 μg/mL-extract composition, respectively.
Example 3: synergistic effect of anti-glycation activity of traditional Chinese medicine source extract composition is proved
The experimental method comprises the following steps:the synergy index is judged by adopting a gold positive average q value method, and the q value is obtained by the following formula:
q＝P A+B /(P A +P B -P A ×P B ). P in the formula A 、P B And P A+B Treatment rates were set A, B and two combination groups, respectively.
q < 1 indicates antagonism after the two extracts are combined; q > 1, indicating synergy after the two extracts are combined, and q=1, indicating additive effect after the two extracts are combined.
According to the above synergy index calculation method, we respectively measure the rhodiola rosea extract, dandelion extract and 70% of the two by weight of single dose: the preferred combination of 30% mixing, specific concentrations are shown in table 2. The inhibition activity of AGEs formation was examined in the same manner as in example 2.
The results are as follows：
TABLE 2 anti-glycation Activity Studies of two Components
The results of the measurement are shown in Table 2. At the three selected concentrations, the preferred compositions exhibit synergistic anti-glycation activity (q > 1) of both extracts, with a significant enhancement in anti-glycation activity. In the early stage of the project, we screen some traditional Chinese medicine extracts with anti-saccharification activity, and the traditional Chinese medicine extracts are combined two by two so as to screen a composition with obvious enhancement effect. We speculate that since different extracts are rich in different anti-glycation active natural product components, such as polyphenols or polysaccharides. If the two extracts adopt different anti-glycation inhibition mechanisms, the combination of the two extracts has mutual enhancement effect, and finally, the synergistic anti-glycation activity is achieved. Compositions, particularly preferred compositions, have synergistically enhanced anti-glycation effects compared to single extracts, and can be used as anti-glycation ingredients.
Example 4: cytotoxicity of Chinese medicinal source extract composition
The experimental method comprises the following steps:the cytotoxicity of the compounds was detected using the CCK-8 kit. Specifically, hepG2 cells, MCF-7 cells and A549 cells were inoculated into 96-well plates, respectively, and cultured at about 5000 cells/200. Mu.L per wellLiquid, cells were cultured overnight. Test compounds were added to each well at different concentrations and incubation was continued for 48 hours. And adding 10 mu L of CCK-8 reagent into each hole, uniformly mixing, continuously culturing for 1-4 hours, observing that the color of the culture solution changes obviously, detecting by using an enzyme-labeled instrument, and measuring the light absorption value of 450 nm. Paclitaxel was used as a positive control.
The results were as follows:
the results are shown in Table 3, and the cell experiment detection shows that the rhodiola rosea extract, the dandelion extract and the preferred combination of the rhodiola rosea extract and the dandelion extract have no obvious cytotoxicity. In connection with example 2, example 3, the combination of both is especially preferred for use as an anti-glycation ingredient for the preparation of cosmetic products.
Table 3: cytotoxicity of different Components against mammalian cells
Example 5: anti-saccharification face cream prepared from traditional Chinese medicine source extract composition as beautifying component
An anti-saccharification face cream comprises the following components in parts by weight:
the cosmetic ingredients appearing herein are all INCI (International Nomenclature of Cosmetic Ingredients), the name specified by the international cosmetic raw material nomenclature.
An oil phase: 3.0 parts of mineral oil, 2.0 parts of squalane, 2.0 parts of caprylic/capric triglyceride, 0.4 part of polyoxyethylene cetylstearyl diether, 2.0 parts of polydimethylsiloxane, and 4.0 parts of glycerol stearic acid/PEG-100 stearic acid;
aqueous phase:anti-glycation composition (preferred composition in example 1) 5.0 parts3.0 parts of glycerin, 4.0 parts of propylene glycol, 0.1 part of allantoin, 0.15 part of carbomer, 74.03 parts of deionized water, 0.02 part of essence, 0.15 part of methylparaben and 0.15 part of propylparaben.
The preparation method comprises the following steps:according to the above formulation, the individual components were weighed, with each mass part being 1g. Mixing the oil phase components, stirring and heatingTo 80 ℃; mixing the water phase components (except essence), stirring and heating to 80deg.C; slowly adding the oil phase into the water phase, stirring while adding, keeping the temperature of the water phase constant at 80 ℃, and continuously stirring for 5 minutes; cooling to 45deg.C, adding essence, stirring, cooling to 25deg.C, and packaging.
It will be apparent to those skilled in the art that various modifications and variations can be made to the present invention without departing from the spirit or scope of the invention. Thus, it is intended that the present invention also include such modifications and alterations insofar as they come within the scope of the appended claims or the equivalents thereof.
Claims (5)
1. A traditional Chinese medicine-derived composition with anti-glycation activity is characterized in that: the traditional Chinese medicine-derived composition comprises the following components in percentage by weight: the composition of the traditional Chinese medicine source has synergistic activity of inhibiting the formation of advanced glycosylation end products, wherein the rhodiola rosea extract is 70% and the dandelion extract is 30% and is purchased from Wuhan Fuxin chemical industry Co.
2. The method for preparing a traditional Chinese medicine-derived composition as claimed in claim 1, wherein: the method comprises the following steps: according to the weight percentage in claim 1, the rhodiola rosea extract and the dandelion extract are respectively weighed, and the two powders are mixed and evenly mixed, thus obtaining the composition of the traditional Chinese medicine source.
3. Use of the traditional Chinese medicine source composition according to claim 1 for preparing a cosmetic product.
4. Use according to claim 3, characterized in that: the cosmetic product is selected from a cream, a toner, an emulsion or a mask.
5. An anti-glycation facial cream, characterized in that: the face cream contains the traditional Chinese medicine-derived composition as claimed in claim 1, and the formula and the weight parts of the face cream are as follows: the traditional Chinese medicine-derived composition of claim 1, wherein the composition comprises 5.0 parts of mineral oil, 3.0 parts of squalane, 2.0 parts of caprylic/capric triglyceride, 0.4 parts of polyoxyethylene cetylstearyl diether, 2.0 parts of polydimethylsiloxane, 4.0 parts of glycerol stearic acid/PEG-100 stearic acid, 3.0 parts of glycerol, 4.0 parts of propylene glycol, 0.1 parts of allantoin, 0.15 parts of carbomer, 74.03 parts of deionized water, 0.02 parts of essence, 0.15 parts of methylparaben and 0.15 parts of propylparaben.
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