CN113662878A - Lipid-containing anti-aging skin-care matrix and application thereof - Google Patents
Lipid-containing anti-aging skin-care matrix and application thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/68—Sphingolipids, e.g. ceramides, cerebrosides, gangliosides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/14—Liposomes; Vesicles
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/35—Ketones, e.g. benzophenone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/65—Collagen; Gelatin; Keratin; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
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- A61K2800/56—Compounds, absorbed onto or entrapped into a solid carrier, e.g. encapsulated perfumes, inclusion compounds, sustained release forms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
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Abstract
The invention relates to a liposome-containing anti-aging skin-care matrix and application thereof. The liposome-containing anti-aging skin care matrix comprises astaxanthin liposome, ceramide liposome, soluble collagen and polypeptide. The components in the liposome-containing anti-aging skin care matrix are matched with each other, have synergistic effect, and have excellent skin tightening and wrinkle removing capabilities. In addition, the astaxanthin liposome is used in the liposome-containing anti-aging skin care matrix, so that the oxidation resistance of astaxanthin is improved, the skin tightening and wrinkle removing capabilities of the liposome-containing anti-aging skin care matrix are further enhanced, and the liposome-containing anti-aging skin care matrix has important application values in daily skin care and cleaning.
Description
Technical Field
The invention belongs to the technical field of cosmetics, relates to a liposome-containing anti-aging skin-care matrix and application thereof, and particularly relates to application of the liposome-containing anti-aging skin-care matrix in preparation of cosmetics.
Background
Skin aging is the most common aging phenomenon in humans and is characterized by sagging, increased wrinkles, deepened wrinkles, dry, rough, dull, lack of luster and elasticity of the skin. With the improvement of the national living standard, people pay more and more attention to skin care, so that skin care cosmetics with the effects of moistening skin, improving wrinkles and fine lines and resisting aging are more and more concerned by people. At present, the components of skin care cosmetics for resisting aging on the market are different, and astaxanthin is one of the more common components for resisting aging. Astaxanthin, also known as astaxanthin and lobster shell pigment, is a carotenoid widely present in the biological world, particularly in feathers of shrimps, crabs, fish, algal bodies, yeasts and birds, and is one of the main carotenoids in marine organisms. Astaxanthin is a chain-breaking antioxidant, has strong oxidation resistance, can remove nitrogen dioxide, sulfide, disulfide, etc., can effectively inhibit lipid peroxidation caused by free radicals, can delay aging, improve immunity and protect organism health.
For example, CN110731912A discloses a whitening anti-aging essence, whose main ingredients include levo-vitamin C, astaxanthin, methyl hesperidin, ferulic acid and phloretin. The astaxanthin, the levorotatory VC and the methyl hesperidin can eliminate excessive free radicals in skin and inhibit the neuraminidase, the ferulic acid and the phloretin have the effects of activating skin, promoting permeation and absorption, and the essence can achieve the effects of whitening and resisting aging.
CN110448475A discloses a whitening anti-aging paste containing hexylresorcinol and astaxanthin, whose main ingredients include cetyl palmitate, hydrogenated polyisobutene, squalane, meadowfoam seed oil, tocopherol acetate, fullerene, hexylresorcinol, astaxanthin, phenoxyethanol, silanediol salicylate, etc. The anti-aging paste can achieve the effects of whitening and resisting aging.
At present, although astaxanthin-containing cosmetics are available on the market, most products have the problem that astaxanthin rapidly deteriorates due to unstable free astaxanthin and easy oxidation, and thus the anti-aging effect of the products is poor. On the other hand, the anti-aging capacity of other components contained in the anti-aging products on the market is limited, and the anti-aging capacity of the products is not greatly improved. Therefore, how to solve the problem of instability of astaxanthin in these products and develop a skin care base with stronger anti-aging effect becomes the research focus of those skilled in the art.
Disclosure of Invention
Aiming at the defects of the prior art, the invention aims to provide a liposome-containing anti-aging skin care matrix and application thereof, in particular to application of the liposome-containing anti-aging skin care matrix in preparing cosmetics.
In order to achieve the purpose, the invention adopts the following technical scheme:
in a first aspect, the present invention provides a liposome-containing anti-aging skin care matrix comprising astaxanthin liposomes, ceramide liposomes, soluble collagen and a polypeptide.
Astaxanthin is a chain-breaking antioxidant, has strong antioxidant capacity, and can effectively inhibit lipid peroxidation caused by free radicals, thereby delaying aging, improving immunity, and protecting organism health. The astaxanthin liposome adopts a high-tech liposome technology to wrap the astaxanthin in the liposome, so that the contact of the astaxanthin liposome with ultraviolet rays and air is avoided, the astaxanthin liposome is prevented from oxidative degradation and discoloration, and the stability of the astaxanthin liposome is greatly improved. In addition, the coated astaxanthin has good water solubility and high bioavailability, has long-acting slow release effect and improves the oxidation resistance.
Ceramide plays roles in resisting oxidation, moisturizing, repairing skin barriers and the like in skin care products, however, detergent, ultraviolet rays, aging and the like can cause the loss of ceramide, and the loss of a large amount of ceramide can cause the damage of the skin barriers and the shrinkage of cells to generate gaps. Compared with free ceramide, the ceramide liposome can increase natural lipid barrier of dry, sensitive and aged skin, thicken horny layer, improve skin tolerance, resist external sensitive invasion, improve skin water holding capacity, reduce wrinkles and enhance skin elasticity.
The soluble collagen can form a film on the cell surface, has the effects of protecting the skin, reducing water loss, preserving moisture and supplementing water, has good histocompatibility and affinity, can directly supplement skin collagen by permeating stratum corneum cells, can promote cell proliferation and differentiation, accelerate the metabolism of the skin cells, promote fibroblasts to synthesize new collagen, and reduce wrinkles.
The polypeptide has the effects of promoting the proliferation of collagen, elastic fiber, polysaccharide and hyaluronic acid, increasing the water content of skin, increasing the thickness of skin and reducing fine wrinkles.
Firstly, the astaxanthin liposome is used for replacing free astaxanthin used in a commercial product to be used as one of main components of the liposome-containing anti-aging skin care matrix, so that the oxidation resistance and the stability of the astaxanthin are improved, the problem that the astaxanthin in the commercial product is rapidly deteriorated is solved, and the anti-aging effect of the liposome-containing anti-aging skin care matrix is enhanced. And secondly, the astaxanthin liposome, the ceramide liposome, the soluble collagen and the polypeptide in the liposome-containing anti-aging skin care matrix are matched with each other to realize synergistic interaction, so that the skin tightening and wrinkle removing capabilities of the liposome-containing anti-aging skin care matrix are further enhanced, and the liposome-containing anti-aging skin care matrix has important application values in daily skin care and cleaning.
Preferably, the liposome-containing anti-aging skin care matrix comprises, by mass, 0.05-1 part of astaxanthin liposome, 1-5 parts of ceramide liposome, 1-10 parts of soluble collagen and 2-5 parts of polypeptide.
Specific values of the above 0.05 to 1 part may be selected from 0.05 part, 0.1 part, 0.15 part, 0.2 part, 0.25 part, 0.3 part, 0.35 part, 0.4 part, 0.45 part, 0.5 part, 0.55 part, 0.6 part, 0.65 part, 0.7 part, 0.75 part, 0.8 part, 0.85 part, 0.9 part, 0.95 part, 1 part and the like.
Specific values in the above 1 to 5 parts may be selected from 1 part, 1.5 parts, 2 parts, 2.5 parts, 3 parts, 3.5 parts, 4 parts, 4.5 parts, 5 parts and the like.
Specific values in the above-mentioned 1 to 10 parts may be selected from 1 part, 1.5 parts, 2 parts, 2.5 parts, 3 parts, 3.5 parts, 4 parts, 4.5 parts, 5 parts, 6 parts, 6.5 parts, 7 parts, 7.5 parts, 8 parts, 8.5 parts, 9 parts, 9.5 parts, 10 parts and the like.
Specific values in the above 2 to 5 parts may be selected from 2 parts, 2.2 parts, 2.5 parts, 2.7 parts, 3 parts, 3.2 parts, 3.5 parts, 3.7 parts, 4 parts, 4.2 parts, 4.5 parts, 4.7 parts, 5 parts and the like.
Other specific point values within the above numerical ranges can be selected, and are not described in detail herein.
Preferably, the ceramide liposome comprises any one of ceramide 1 liposome, ceramide 3 liposome or ceramide 6 liposome or a combination of at least two thereof.
The combination of at least two of the ceramide 1 liposome and the ceramide 3 liposome, the ceramide 3 liposome and the ceramide 6 liposome, the ceramide 1 liposome and the ceramide 6 liposome, and the like can be selected in any combination mode, and the description is omitted, and the combination of the ceramide 1 liposome, the ceramide 3 liposome and the ceramide 6 liposome is preferred.
Compared with other choices, three components in the composition of the ceramide 1 liposome, the ceramide 3 liposome and the ceramide 6 liposome are mutually matched and synergized, so that the anti-aging effect of the liposome-containing anti-aging skin care matrix is further enhanced.
Preferably, the ceramide liposome is a liposome comprising any one of ceramide 1, ceramide 3, or ceramide 6, or a combination of at least two thereof.
The combination of at least two of the above compounds, for example, the combination of ceramide 1 and ceramide 3, the combination of ceramide 3 and ceramide 6, the combination of ceramide 1 and ceramide 6, and the like, may be selected in any combination manner, and thus, description thereof is omitted, and the combination of ceramide 1, ceramide 3, and ceramide 6 is preferred.
Compared with other types of liposomes, the liposome carrying ceramide 1, ceramide 3 and ceramide 6 can further enhance the anti-aging effect of the liposome-containing anti-aging skin care matrix.
Preferably, the polypeptide comprises any one of acetyl tripeptide-1, acetyl tetrapeptide-11, acetyl tetrapeptide-9, acetyl hexapeptide-7, acetyl hexapeptide-8, palmitoyl pentapeptide-4, or palmitoyl pentapeptide-5, or a combination of at least two thereof.
The combination of at least two of the three or more of acetyl tripeptide-1 and acetyl tetrapeptide-11, acetyl tetrapeptide-9 and acetyl hexapeptide-7, acetyl hexapeptide-8 and palmitoyl pentapeptide-4, palmitoyl pentapeptide-4 and palmitoyl pentapeptide-5, and any combination thereof may be selected, and thus detailed description thereof is omitted, and the combination of acetyl hexapeptide-8, acetyl tripeptide-1 and acetyl tetrapeptide-11 is preferred.
Compared with other choices, the three components in the composition of the acetyl hexapeptide-8, the acetyl tripeptide-1 and the acetyl tetrapeptide-11 are matched with each other for synergism, so that the anti-aging effect of the liposome-containing anti-aging skin care matrix is further enhanced.
In a second aspect, the present invention provides a use of the lipid-containing anti-aging skin care base according to the first aspect in the preparation of a cosmetic.
Preferably, the cosmetic comprises any one of essence cream, face cream, essence, toner or skin care emulsion.
Preferably, the content of the liposome-containing anti-aging skin care base in the cosmetic is 0.2-20% by mass, such as 0.2%, 0.5%, 1%, 2%, 4%, 6%, 8%, 10%, 12%, 14%, 16%, 18%, 20%, etc., and other specific values in the numerical range can be selected, which is not described in detail herein.
In a third aspect, the invention provides an anti-aging essence cream, which is prepared from water and the lipid-containing anti-aging skin care matrix of the first aspect, and further comprises any one or a combination of at least two of an emulsifier, an emollient, a humectant, an anti-allergic agent, an antioxidant, a chelating agent, an antibacterial agent or a pH regulator.
The combination of at least two of the above components, such as the combination of an emulsifier and an emollient, the combination of an emollient and a humectant, the combination of an anti-allergic agent and an antibacterial agent, the combination of an emulsifier and a pH regulator, and the like, can be selected in any combination manner, and will not be described in detail herein.
Preferably, the emulsifier comprises any one of or a combination of at least two of C20-22 alcohol phosphate (and) C20-22 alcohol, glyceryl stearate (and) PEG-100 stearate, hydrogenated lecithin, or ammonium acryloyldimethyl taurate/VP copolymer.
The combination of at least two of the above-mentioned compounds, such as the combination of C20-22 alcohol phosphate (and) C20-22 alcohol with glyceryl stearate (and) PEG-100 stearate, the combination of glyceryl stearate (and) PEG-100 stearate with hydrogenated lecithin, the combination of hydrogenated lecithin with ammonium acryloyldimethyl taurate/VP copolymer, etc., can be selected in any combination manner, and will not be described in detail herein.
Preferably, the emollient comprises any one or a combination of at least two of squalane, caprylic/capric triglyceride, cetearyl alcohol or dimethicone.
The combination of at least two of the above-mentioned compounds, such as the combination of caprylic/capric triglyceride and cetearyl alcohol, the combination of cetearyl alcohol and polydimethylsiloxane, the combination of caprylic/capric triglyceride and polydimethylsiloxane, and the like, can be selected in any combination manner, and thus, the description thereof is omitted.
Preferably, the humectant comprises any one of glycerin, 1, 3-butylene glycol or sodium hyaluronate or a combination of at least two of them.
The combination of at least two of the above-mentioned compounds, for example, the combination of 1, 3-butanediol and glycerin, the combination of 1, 3-butanediol and sodium hyaluronate, the combination of sodium hyaluronate and glycerin, etc., can be selected in any other combination manner, and thus, the details are not repeated herein.
Preferably, the anti-sensitivity agent comprises dipotassium glycyrrhizinate and/or allantoin.
Preferably, the antioxidant comprises butylated hydroxytoluene.
Preferably, the chelating agent comprises disodium edetate.
Preferably, the antibacterial agent comprises any one of methyl paraben, caprylhydroxamic acid, 1, 2-hexanediol or ethylhexylglycerin or a combination of at least two of them.
The combination of at least two of the above compounds, such as caprylhydroxamic acid and 1, 2-hexanediol, methyl paraben and caprylhydroxamic acid, caprylhydroxamic acid and ethylhexylglycerin, can be selected according to any combination method, and thus, the detailed description thereof is omitted.
Preferably, the pH adjusting agent comprises any one of triethanolamine, aminomethyl propanol or tromethamine or a combination of at least two thereof.
The combination of at least two of the above-mentioned compounds, such as the combination of triethanolamine and aminomethyl propanol, the combination of aminomethyl propanol and tromethamine, the combination of triethanolamine and tromethamine, etc., can be selected in any other combination manner, and thus, the details are not repeated herein.
In a fourth aspect, the present invention provides a method for preparing the anti-aging essence cream according to the third aspect, the method comprising the steps of:
(1) mixing the softening agent, part of the emulsifier and the antioxidant to obtain a first mixed solution; mixing the anti-allergic agent, water, the humectant, the chelating agent, the rest of the emulsifier and part of the antibacterial agent to obtain a second mixed solution;
(2) mixing the first mixed solution and the second mixed solution obtained in the step (1), and homogenizing to obtain a third mixed solution;
(3) mixing the pH regulator with the third mixed solution obtained in the step (2), and stirring to obtain a fourth mixed solution;
(4) and (4) mixing the residual antibacterial agent, the fourth mixed solution obtained in the step (3) and the lipid-containing anti-aging skin care matrix of the first aspect to obtain the anti-aging essence cream.
The mass percentage of the partial emulsifier in the step (1) in all emulsifiers is 70% -90%, for example, 70%, 72%, 75%, 77%, 80%, 82%, 85%, 87%, 90%, etc., and other specific values in the numerical range can be selected, which is not described herein again.
The mass percentage of the part of the antibacterial agents in the step (1) in all the antibacterial agents is 5% -30%, such as 5%, 7%, 10%, 12%, 15%, 17%, 20%, 22%, 25%, 27%, 30%, etc., and other specific points in the numerical range can be selected, and are not repeated herein.
Preferably, the mixing of the first mixed solution in step (1) is performed at 80-85 ℃, for example, 80 ℃, 80.5 ℃, 81 ℃, 81.5 ℃, 82 ℃, 82.5 ℃, 83 ℃, 83.5 ℃, 84 ℃, 84.5 ℃, 85 ℃ and the like, and other specific values in the numerical range can be selected, and are not repeated herein.
Preferably, the mixing of the first mixed solution in step (1) further includes a heat preservation operation, the heat preservation time is 5-20min, for example, 5min, 7min, 10min, 12min, 15min, 17min, 20min, and the like, and other specific values within the value range can be selected, which is not described herein again.
Preferably, the mixing of the second mixed solution in step (1) is performed at 85-90 ℃, for example, 85 ℃, 85.5 ℃, 86 ℃, 86.5 ℃, 87 ℃, 87.5 ℃, 88 ℃, 88.5 ℃, 89 ℃, 89.5 ℃, 90 ℃ and the like, and other specific values in the numerical range can be selected, and are not repeated herein.
Preferably, the mixing of the second mixed solution in step (1) further includes a heat preservation operation, the heat preservation time is 5-20min, for example, 5min, 7min, 10min, 12min, 15min, 17min, 20min, and the like, and other specific values within the value range can be selected, which is not described herein again.
Preferably, the homogenization time in the step (2) is 1-5min, and the homogenization speed is 8000-10000 rpm.
The specific value of 1-5min can be selected from 1min, 1.5min, 2min, 2.5min, 3min, 3.5min, 4min, 4.5min, 5min, etc.
Specific values in 8000-.
Other specific point values within the above numerical ranges can be selected, and are not described in detail herein.
Preferably, the mixing in step (3) is performed at 50-70 ℃, such as 50 ℃, 52 ℃, 55 ℃, 57 ℃, 60 ℃, 62 ℃, 65 ℃, 67 ℃, 70 ℃ and the like, and other specific values in the numerical range can be selected, which is not described in detail herein.
Preferably, the mixing in step (4) is performed at 30-45 ℃, such as 30 ℃, 32 ℃, 35 ℃, 37 ℃, 40 ℃, 62 ℃, 45 ℃ and the like, and other specific values in the numerical range can be selected, which is not described in detail herein.
Compared with the prior art, the invention has the following beneficial effects:
firstly, the astaxanthin liposome is used for replacing free astaxanthin used in a commercial product to be used as one of main components of the liposome-containing anti-aging skin care matrix, so that the oxidation resistance and the stability of the astaxanthin are improved, the problem that the astaxanthin in the commercial product is rapidly deteriorated is solved, and the anti-aging effect of the liposome-containing anti-aging skin care matrix is enhanced. And secondly, the astaxanthin liposome, the ceramide liposome, the soluble collagen and the polypeptide in the liposome-containing anti-aging skin care matrix are matched with each other to realize synergistic interaction, so that the skin tightening and wrinkle removing capabilities of the liposome-containing anti-aging skin care matrix are further enhanced, and the liposome-containing anti-aging skin care matrix has important application values in daily skin care and cleaning.
Detailed Description
To further illustrate the technical means and effects of the present invention, the following further describes the technical solution of the present invention with reference to the preferred embodiments of the present invention, but the present invention is not limited to the scope of the embodiments.
The following examples, comparative examples, application examples and comparative application examples relate to the following raw material information:
example 1
The embodiment provides a liposome-containing anti-aging skin care matrix, which comprises 0.5 part of astaxanthin liposome, 2 parts of ceramide 1 liposome, 3 parts of soluble collagen and 82.5 parts of acetyl hexapeptide by weight.
The preparation method of the ceramide 1 liposome comprises the following steps:
mixing glycerol 20g, lecithin 5g, hydrogenated lecithin 1g, ceramide 10.5g, tocopherol acetate 0.3g, mannitol 5g and diethylene glycol ethyl ether 10g, heating to 85 deg.C, stirring and mixing until the solution is uniform and transparent to obtain a first mixed solution. Weighing 57.2g of water, heating to 85 ℃, starting a homogenizer at a homogenizing speed of 3500rpm and a stirring speed of 150rpm, slowly adding the first mixed solution, homogenizing for 10min, stopping homogenizing, stirring and cooling to 50 ℃, adding 0.5g of p-hydroxyacetophenone and 0.5g of 1, 2-hexanediol, and stirring and mixing until the p-hydroxyacetophenone and the 1, 2-hexanediol are completely dissolved to obtain the compound.
The preparation method of the lipidosome-containing anti-aging skin-care matrix only needs simple physical mixing of all the components.
Example 2
The embodiment provides a liposome-containing anti-aging skin care matrix, which comprises 0.3 part of astaxanthin liposome, 3 parts of ceramide 3 liposome, 2.7 parts of soluble collagen and 42 parts of palmitoyl pentapeptide by weight.
The preparation method of the ceramide 3 liposome is different from the preparation method of the ceramide 1 liposome in example 1 only in that the ceramide 10.5g is replaced by the ceramide 30.5g, and other conditions are not changed.
The preparation method of the liposome-containing anti-aging skin care matrix refers to example 1.
Example 3
The embodiment provides a liposome-containing anti-aging skin care matrix, which comprises 0.1 part of astaxanthin liposome, 1 part of ceramide 6 liposome, 5 parts of soluble collagen and 71.9 parts of acetyl hexapeptide by weight.
The preparation method of the ceramide 6 liposome is different from the preparation method of the ceramide 1 liposome in example 1 only in that the ceramide 10.5g is replaced by the ceramide 60.5g, and other conditions are not changed.
The preparation method of the liposome-containing anti-aging skin care matrix refers to example 1.
Example 4
This example provides a lipid-containing anti-aging skin care base, which is different from example 1 only in that "2 parts of ceramide 1 liposome" is replaced by "2 parts of ceramide 3 liposome", and other components and contents are not changed.
The preparation process is as in example 1.
Example 5
This example provides a lipid-containing anti-aging skin care base, which is different from example 1 only in that "2 parts of ceramide 1 liposome" is replaced by "2 parts of ceramide 6 liposome", and other components and contents are not changed.
The preparation process is as in example 1.
Example 6
This example provides a lipid-containing anti-aging skin care base, which is different from example 1 only in that "2 parts of ceramide 1 liposome" is replaced by "2 parts of a combination of ceramide 1 liposome and ceramide 6 liposome", wherein the mass ratio of the ceramide 1 liposome to the ceramide 6 liposome is 1:3, and other components and contents are not changed.
The preparation process is as in example 1.
Example 7
This example provides a lipid-containing anti-aging skin care base, which is different from example 1 only in that "2 parts of ceramide 1 liposome" is replaced by "2 parts of a combination of ceramide 1 liposome and ceramide 3 liposome", wherein the mass ratio of the ceramide 1 liposome to the ceramide 3 liposome is 1:1, and other components and contents are not changed.
The preparation process is as in example 1.
Example 8
This example provides a lipid-containing anti-aging skin care base, which is different from example 1 only in that "2 parts of ceramide 1 liposome" is replaced by "2 parts of a combination of ceramide 3 liposome and ceramide 6 liposome", wherein the mass ratio of the ceramide 3 liposome to the ceramide 6 liposome is 1:3, and other components and contents are not changed.
The preparation process is as in example 1.
Example 9
This example provides a lipid-containing anti-aging skin care base, which is different from example 1 only in that "2 parts of ceramide 1 liposome" is replaced by "2 parts of a combination of ceramide 1 liposome, ceramide 3 liposome and ceramide 6 liposome", wherein the mass ratio of the ceramide 1 liposome, the ceramide 3 liposome and the ceramide 6 liposome is 1:1:3, and other components and contents are not changed.
The preparation process is as in example 1.
Example 10
This example provides a lipid-containing anti-aging skin care base, which is different from example 1 only in that "2 parts of ceramide 1 liposome" is replaced by "2 parts of ceramide 1 and ceramide 3-entrapped liposome", and other components and contents are not changed.
The preparation method of the ceramide 1 and ceramide 3-entrapped liposome is different from the preparation method of the ceramide 1 liposome in example 1 only in that the ceramide 10.5g is replaced by the ceramide 10.25g and the ceramide 30.25g, and other conditions are not changed.
The preparation method of the liposome-containing anti-aging skin care matrix refers to example 1.
Example 11
This example provides a lipid-containing anti-aging skin care base which is different from example 1 only in that "2 parts of ceramide 1 liposome" is replaced with "2 parts of liposome encapsulating ceramide 1, ceramide 3 and ceramide 6", and other components and contents are not changed.
The preparation method of the ceramide 1, ceramide 3 and ceramide 6-entrapped liposome is different from that of the ceramide 1 liposome of example 1 only in that the ceramide 10.5g is replaced by the ceramide 10.1g, the ceramide 30.1g and the ceramide 60.3g, and other conditions are not changed.
The preparation method of the liposome-containing anti-aging skin care matrix refers to example 1.
Example 12
This example provides a liposome-containing anti-aging skin care base which differs from example 1 only in that "acetyl hexapeptide-85 parts" is replaced with "acetyl tripeptide-15 parts", and the other components and contents are not changed.
The preparation process is as in example 1.
Example 13
This example provides a liposome-containing anti-aging skin care base which differs from example 1 only in that "acetyl hexapeptide-85 parts" is replaced with "acetyl tetrapeptide-115 parts", and the other components and contents are not changed.
The preparation process is as in example 1.
Example 14
This example provides a liposome-containing anti-aging skin care base which differs from example 1 only in that "acetyl hexapeptide-85 parts" is replaced with "5 parts of a combination of acetyl hexapeptide-8 and acetyl tetrapeptide-11", wherein the mass ratio of acetyl hexapeptide-8 to acetyl tetrapeptide-11 is 4:3, and the other components and contents are not changed.
The preparation process is as in example 1.
Example 15
This example provides a liposome-containing anti-aging skin care base which differs from example 1 only in that "acetyl hexapeptide-85 parts" is replaced with "5 parts of a combination of acetyl hexapeptide-8 and acetyl tripeptide-1", wherein the mass ratio of acetyl hexapeptide-8 to acetyl tripeptide-1 is 4:1, and the other components and contents are not changed.
The preparation process is as in example 1.
Example 16
This example provides a liposome-containing anti-aging skin care base which differs from example 1 only in that "acetyl hexapeptide-85 parts" is replaced with "5 parts of a combination of acetyl tetrapeptide-11 and acetyl tripeptide-1", wherein the mass ratio of acetyl tetrapeptide-11 to acetyl tripeptide-1 is 3:1, and the other components and contents are not changed.
The preparation process is as in example 1.
Example 17
This example provides a liposome-containing anti-aging skin care base which differs from example 1 only in that "acetyl hexapeptide-85 parts" is replaced with "acetyl hexapeptide-8, acetyl tetrapeptide-11 and acetyl tripeptide-1 combined with 5 parts", wherein the mass ratio of acetyl hexapeptide-8, acetyl tetrapeptide-11 and acetyl tripeptide-1 is 4:3:1, and other components and contents are not changed.
The preparation process is as in example 1.
Comparative example 1
This comparative example provides a single astaxanthin liposome composition.
Comparative example 2
This comparative example provides a single ceramide 1 liposomal composition.
Comparative example 3
The present comparative example provides a single soluble collagen component.
Comparative example 4
This comparative example provides a single acetyl hexapeptide-8 component.
Comparative example 5
This comparative example provides a liposome-containing anti-aging skin care base which differs from example 1 only in that the astaxanthin liposome component is absent and the other components and amounts are unchanged.
The preparation process is as in example 1.
Comparative example 6
This comparative example provides a lipid-containing anti-aging skin care base which differs from example 1 only in the absence of the ceramide 1 liposome component, with no other components or amounts.
The preparation process is as in example 1.
Comparative example 7
This comparative example provides a liposome-containing anti-aging skin care base which differs from example 1 only in that the component soluble collagen is absent and the other components and amounts are unchanged.
The preparation process is as in example 1.
Comparative example 8
This comparative example provides a liposome-containing anti-aging skin care base which differs from example 1 only in the absence of the acetyl hexapeptide-8 component, with no other components and amounts.
The preparation process is as in example 1.
Comparative example 9
This comparative example provides a liposome-containing anti-aging skin care base which differs from example 1 only in that "0.5 parts of astaxanthin liposome" was replaced with "0.5 parts of commercially available astaxanthin", and the other components and contents were not changed.
The preparation process is as in example 1.
Application example 1
The present application provides an anti-aging essence cream prepared from, by mass, 2% of C20-22 alcohol phosphate (and) C20-22 alcohol, 1% of glyceryl stearate (and) PEG-100 stearate, 0.5% of hydrogenated lecithin, 3% of caprylic/capric triglyceride, 3% of cetostearyl alcohol, 1.5% of squalane, 1.5% of polydimethylsiloxane, 0.3% of butylated hydroxytoluene, 5% of glycerol, 0.2% of dipotassium glycyrrhizinate, 0.06% of disodium ethylenediaminetetraacetate, 5% of 1, 3-butanediol, 0.5% of ammonium acryloyldimethyltaurate/VP copolymer, 0.1% of sodium hyaluronate, 0.6% of allantoin, 0.1% of methyl paraben, 0.2% of aminomethyl propanol, 0.3% of caprylyl hydroxamic acid, 0.3% of ethylhexylglycerin, 0.3% of 1, 8% of the lipid-containing anti-aging skin care base of example 1, the balance being water.
The preparation method comprises the following steps:
(1) mixing C20-22 alcohol phosphate (and) C20-22 alcohol, glyceryl stearate (and) PEG-100 stearate, hydrogenated lecithin, caprylic/capric triglyceride, cetostearyl alcohol, squalane, polydimethylsiloxane, butylated hydroxytoluene at 83 deg.C, and maintaining for 10min to obtain first mixed solution; mixing glycerol, dipotassium glycyrrhizinate, disodium ethylene diamine tetraacetate, 1, 3-butanediol, ammonium acryloyl dimethyl taurate/VP copolymer, sodium hyaluronate, allantoin, methyl p-hydroxybenzoate and water at 88 deg.C, and keeping the temperature for 10min to obtain a second mixed solution;
(2) mixing the first mixed solution and the second mixed solution obtained in the step (1), and homogenizing at 9000rpm for 2min to obtain a third mixed solution;
(3) mixing aminomethyl propanol with the third mixed solution obtained in the step (2) at 70 ℃, and uniformly stirring at the speed of 300rpm to obtain a fourth mixed solution;
(4) and (3) mixing caprylyl hydroximic acid, ethylhexyl glycerin, 1, 2-hexanediol, the fourth mixed solution obtained in the step (4) and the lipid-containing anti-aging skin care base obtained in the example 1 at the temperature of 45 ℃ to obtain the anti-aging essence cream.
Application example 2
The application example provides an anti-aging essence cream which is prepared from the following raw materials, by mass, 3% of C20-22 alcohol phosphate (and) C20-22 alcohol, 0.5% of hydrogenated lecithin, 4.5% of caprylic/capric triglyceride, 4.5% of cetostearyl alcohol, 0.3% of butylated hydroxytoluene, 10% of glycerol, 0.8% of dipotassium glycyrrhizinate, 0.06% of disodium ethylene diamine tetraacetic acid, 0.1% of methyl p-hydroxybenzoate, 0.5% of ammonium acryloyldimethyl taurate/VP copolymer, 0.1% of sodium hyaluronate, 0.2% of triethanolamine, 0.9% of caprylyl hydroximic acid, 8% of the liposome-containing anti-aging skin care base of example 2, and the balance of water.
The preparation method comprises the following steps:
(1) mixing C20-22 alcohol phosphate (and) C20-22 alcohol, hydrogenated lecithin, caprylic/capric triglyceride, cetostearyl alcohol and butylated hydroxytoluene at 80 deg.C, and maintaining the temperature for 20min to obtain first mixed solution; mixing glycerol, dipotassium glycyrrhizinate, disodium ethylene diamine tetraacetate, methyl p-hydroxybenzoate, ammonium acryloyl dimethyl taurate/VP copolymer, sodium hyaluronate and water at 85 ℃, and keeping the temperature for 20min to obtain a second mixed solution;
(2) mixing the first mixed solution and the second mixed solution obtained in the step (1), and homogenizing at 8000rpm for 5min to obtain a third mixed solution;
(3) mixing triethanolamine with the third mixed solution obtained in the step (2) at 50 ℃, and uniformly stirring at the speed of 200rpm to obtain a fourth mixed solution;
(4) and (3) mixing the caprylyl hydroximic acid, the fourth mixed solution obtained in the step (4) and the lipid-containing anti-aging skin-care substrate obtained in the example 1 at the temperature of 30 ℃ to obtain the anti-aging essence cream.
Application example 3
The application example provides an anti-aging essence cream which is prepared from the following raw materials, by mass, 3% of glyceryl stearate (and) PEG-100 stearate, 0.5% of hydrogenated lecithin, 6% of caprylic/capric triglyceride, 3% of squalane, 0.3% of butylated hydroxytoluene, 10.1% of glycerol, 0.5% of ammonium acryloyldimethyl taurate/VP copolymer, 0.8% of allantoin, 0.06% of disodium ethylenediamine tetraacetic acid, 0.1% of methyl p-hydroxybenzoate, 0.2% of tromethamine, 0.9% of 1, 2-hexanediol, 8% of the liposome-containing anti-aging skin care matrix prepared in example 3, and the balance of water.
The preparation method comprises the following steps:
(1) mixing glyceryl stearate (and) PEG-100 stearate, hydrogenated lecithin, caprylic/capric triglyceride, squalane and butylated hydroxytoluene at 85 deg.C, and maintaining the temperature for 5min to obtain a first mixed solution; mixing glycerol, acryloyl dimethyl ammonium taurate/VP copolymer, allantoin, ethylene diamine tetraacetic acid disodium, methyl p-hydroxybenzoate and water at 90 ℃, and keeping the temperature for 5min to obtain a second mixed solution;
(2) mixing the first mixed solution and the second mixed solution obtained in the step (1), and homogenizing at the speed of 10000rpm for 1min to obtain a third mixed solution;
(3) mixing tromethamine with the third mixed solution obtained in the step (2) at the temperature of 60 ℃, and uniformly stirring at the speed of 500rpm to obtain a fourth mixed solution;
(4) and (3) mixing the 1, 2-hexanediol, the fourth mixed solution obtained in the step (4) and the lipid-containing anti-aging skin care base obtained in the example 3 at the temperature of 40 ℃ to obtain the anti-aging essence cream.
Application examples 4 to 17
Application examples 4 to 17 provide fourteen anti-aging essence creams, which are different from the application example 1 only in that the lipid-containing anti-aging skin care base of the example 1 is replaced with the lipid-containing anti-aging skin care bases of the examples 4 to 17 respectively in the same addition amount, and other preparation raw materials and contents are not changed.
The preparation process is as in application example 1.
Comparative application examples 1 to 4
Comparative application examples 1 to 4 provide four anti-aging essence creams, which are different from application example 1 only in that the lipid-containing anti-aging skin care base of example 1 is replaced with the single components of comparative examples 1 to 4 in the same addition amount, respectively, and other preparation raw materials and contents are not changed.
The preparation process is as in application example 1.
Comparative application examples 5 to 9
Comparative application examples 5 to 9 provide five anti-aging essence creams, which are different from application example 1 only in that the lipid-containing anti-aging skin care base of example 1 is replaced with the lipid-containing anti-aging skin care bases of comparative examples 5 to 9, respectively, in the same amount, and other preparation raw materials and contents are not changed.
The preparation process is as in application example 1.
Comparative application example 10
Comparative application example 10 provides an anti-aging essence cream which is different from application example 1 only in that the lipid-containing anti-aging skin care base of example 1 is absent, the absent amount is supplemented with water, and other preparation raw materials and contents are not changed.
The preparation process is as in application example 1.
Test example 1
The stability tests were performed on the anti-aging essence creams prepared in application examples 1 to 17 and comparative application example 9:
(1) sample stability test at high temperature:
30g of the test sample is respectively placed in sample bottles A1-A18, each group of sample bottles are simultaneously placed in the same biochemical incubator, the culture temperature is set to be 45 ℃, and the change of each group of samples is observed after 1 week, 2 weeks, 4 weeks, 8 weeks and 12 weeks respectively.
(2) Sample stability testing under illumination:
respectively placing 30g of a tested sample in sample bottles B1-B18, simultaneously placing each group of sample bottles in the same climatic incubator, setting the culture condition to be uniform illumination, setting the illumination intensity to be common light 3000LX, and observing the color change of each group of samples after 1 week, 2 weeks, 4 weeks and 8 weeks respectively.
The results show that: the anti-aging essence creams prepared in the application examples 1-9 and 12-17 show no agglomeration after discoloration at 45 ℃ and no agglomeration after discoloration under illumination after 8 weeks of test, show no discoloration at 45 ℃ but have a small part of agglomeration and no agglomeration after discoloration under illumination after 12 weeks of test, the anti-aging essence creams prepared in the application examples 10 and 11 still show no agglomeration after discoloration at 45 ℃ and no agglomeration after discoloration under illumination after 12 weeks of test, and the anti-aging essence cream prepared in the application example 9 has the phenomena of slight discoloration at 45 ℃ and slight discoloration under illumination after 1 week of test, and has the phenomena of discoloration at 45 ℃ and discoloration under illumination after 2 weeks of test. It is demonstrated that the anti-aging essence cream of the present invention can be stable for a long time at a high temperature of 45 ℃ and under a light condition, wherein the anti-aging essence creams prepared in application examples 10 and 11 have the best stability, and the anti-aging essence cream prepared in application example 9 has a poorer stability.
Test example 2
And (3) evaluating the safety performance of the anti-aging essence cream prepared in the application examples 1-17:
selecting 170 social volunteers with the ages of 20-45 years, 85 females and 85 males meeting the requirements, randomly dividing the social volunteers into 17 groups, respectively trying the anti-aging essence cream prepared in application examples 1-17 according to the groups of 5 females and 5 males, respectively taking 0.020-0.025mL of a tested sample, putting the tested sample into a spot tester cell, and not performing any treatment on a control hole. The spot test device with the test substance is applied to the back or forearm of the subject with hypoallergenic tape, and is applied to the skin with palm pressure for 24 h. Skin reactions were observed at 30min (after disappearance of the indentation), 24h and 48h after removal of the plaque from the test article, respectively, according to the criteria of table 1.
TABLE 1
The results show that: application examples 1 to 17 of the present invention are all negative reactions, which show that the safety of the plant composition and the derivative thereof according to the present invention is ensured, and adverse reactions such as skin irritation, sensitization (except people who are allergic to the product) and the like are not generated.
Test example 3
The anti-aging abilities of the anti-aging essence creams prepared in the application examples 1 to 17 and the comparative application examples 1 to 10 are tested:
270 social volunteers with the ages of 20-45 years, 135 females and 135 males meeting the requirements are selected and randomly divided into 27 groups, 5 females and 5 males in each group, and the anti-aging essence cream prepared in application examples 1-17 and comparative application examples 1-10 is tried according to the group respectively (other skin care products are not used in the test period).
The face of a tested person is cleaned firstly, the face cleaning product and the face cleaning time of each person are the same, after the skin is cleaned, the same amount of essence cream containing the anti-aging skin care matrix is uniformly smeared on the whole face and eyes, the essence cream is gently massaged until the essence cream is completely absorbed, and the essence cream is used for 2 months continuously once every morning and evening.
(1) Ability to improve skin elasticity test:
skin elasticity R before, after 30 minutes and 1 week and 4 weeks after continuous application was measured by a skin elasticity measuring instrument (Cutomermapa 580, CK Co., Germany) using cheeks of 5cm × 5cm as a test area2The values are tested, the skin elasticity R of each test area2Values were averaged over 5 measurements and then over all volunteers in the group. Skin elasticity R2Values closer to 1 indicate better skin elasticity, and the test results are shown in the following table.
TABLE 2
(2) And (3) testing the wrinkle removing capability:
skin wrinkles (including crow's feet and french wrinkles) were measured before, after 1 week, 4 weeks and 8 weeks of continuous use using Visia-CR (Canfield, usa) to calculate the reduction rate of crow's feet and french wrinkles for each volunteer, and the results were averaged as shown in the table below.
TABLE 3
The results show that: the anti-aging essence cream prepared in application examples 1-17 has good capability of improving skin elasticity and wrinkle removing capability, namely has excellent anti-aging effect. The anti-aging essence creams prepared in the application examples 6 to 8, 10 and 14 to 16 have a slightly better effect than the application example 1, the anti-aging essence creams prepared in the application examples 9, 11 and 17 have a best effect, the anti-aging essence creams prepared in the application examples 5 to 9 have a slightly poorer effect than the application example 1, the anti-aging essence creams prepared in the application examples 1 to 4 have a poorer effect than the application example 1, and the anti-aging essence cream prepared in the application example 10 has a worst effect.
In conclusion, the astaxanthin liposome is used for replacing free astaxanthin used in a commercial product to serve as one of main components of the liposome-containing anti-aging skin care matrix, so that the oxidation resistance and stability of the astaxanthin are improved, the problem that the astaxanthin in the commercial product is rapidly deteriorated is solved, and the anti-aging effect of the liposome-containing anti-aging skin care matrix is enhanced. In addition, the astaxanthin liposome, the ceramide liposome, the soluble collagen and the polypeptide in the liposome-containing anti-aging skin care matrix are matched with each other, have synergistic interaction, further enhance the skin tightening and wrinkle removing capabilities of the liposome-containing anti-aging skin care matrix, and have important application values in daily skin care and cleaning.
The applicant states that the invention is illustrated by the above examples to the lipid-containing anti-aging skin care base and the application thereof, but the invention is not limited to the above examples, i.e. the invention is not meant to be implemented by relying on the above examples. It should be understood by those skilled in the art that any modification of the present invention, equivalent substitutions of the raw materials of the product of the present invention, addition of auxiliary components, selection of specific modes, etc., are within the scope and disclosure of the present invention.
The preferred embodiments of the present invention have been described in detail, however, the present invention is not limited to the specific details of the above embodiments, and various simple modifications may be made to the technical solution of the present invention within the technical idea of the present invention, and these simple modifications are within the protective scope of the present invention.
It should be noted that the various technical features described in the above embodiments can be combined in any suitable manner without contradiction, and the invention is not described in any way for the possible combinations in order to avoid unnecessary repetition.
Claims (10)
1. The liposome-containing anti-aging skin care matrix is characterized by comprising astaxanthin liposomes, ceramide liposomes, soluble collagen and polypeptide.
2. The liposome-containing anti-aging skin care matrix of claim 1, wherein the liposome-containing anti-aging skin care matrix comprises, by mass, 0.05 to 1 part of astaxanthin liposomes, 1 to 5 parts of ceramide liposomes, 1 to 10 parts of soluble collagen and 2 to 5 parts of polypeptide;
preferably, the ceramide liposome comprises any one of or a combination of at least two of ceramide 1 liposome, ceramide 3 liposome or ceramide 6 liposome, preferably the combination of ceramide 1 liposome, ceramide 3 liposome and ceramide 6 liposome;
preferably, the ceramide liposome is a liposome comprising any one or a combination of at least two of ceramide 1, ceramide 3, or ceramide 6, preferably a liposome comprising ceramide 1, ceramide 3, and ceramide 6;
preferably, the polypeptide comprises any one of or a combination of at least two of acetyl tripeptide-1, acetyl tetrapeptide-11, acetyl tetrapeptide-9, acetyl hexapeptide-7, acetyl hexapeptide-8, palmitoyl pentapeptide-4 or palmitoyl pentapeptide-5, preferably a combination of acetyl hexapeptide-8, acetyl tripeptide-1 and acetyl tetrapeptide-11.
3. Use of the liposome-containing anti-aging skin care base of claim 1 or 2 in the preparation of a cosmetic.
4. The use according to claim 3, wherein the cosmetic comprises any one of essence cream, face cream, essence, toner or skin care emulsion;
preferably, the lipid-containing anti-aging skin care matrix accounts for 0.2-20% of the cosmetic by mass.
5. An anti-aging essence cream, which is prepared from water and the liposome-containing anti-aging skin care base of claim 1 or 2, and further comprises any one or a combination of at least two of an emulsifier, a moisturizer, a humectant, an anti-sensitivity agent, an antioxidant, a chelating agent, an antibacterial agent or a pH regulator.
6. The anti-aging cream of claim 5, wherein the emulsifier comprises any one or a combination of at least two of C20-22 alcohol phosphate (and) C20-22 alcohol, glyceryl stearate (and) PEG-100 stearate, hydrogenated lecithin, or ammonium acryloyldimethyl taurate/VP copolymer;
preferably, the emollient comprises any one or a combination of at least two of caprylic/capric triglyceride, squalane, cetearyl alcohol or dimethicone;
preferably, the humectant comprises any one or a combination of at least two of glycerin, 1, 3-butanediol or sodium hyaluronate;
preferably, the anti-sensitivity agent comprises dipotassium glycyrrhizinate and/or allantoin;
preferably, the antioxidant comprises butylated hydroxytoluene;
preferably, the chelating agent comprises disodium ethylenediaminetetraacetate;
preferably, the antibacterial agent comprises any one or a combination of at least two of methylparaben, caprylhydroxamic acid, 1, 2-hexanediol or ethylhexylglycerin;
preferably, the pH adjusting agent comprises any one of triethanolamine, aminomethyl propanol or tromethamine or a combination of at least two thereof.
7. The method for preparing the anti-aging essence cream according to claim 5 or 6, wherein the method comprises the steps of:
(1) mixing the softening agent, part of the emulsifier and the antioxidant to obtain a first mixed solution; mixing the anti-allergic agent, water, the humectant, the chelating agent, the rest of the emulsifier and part of the antibacterial agent to obtain a second mixed solution;
(2) mixing the first mixed solution and the second mixed solution obtained in the step (1), and homogenizing to obtain a third mixed solution;
(3) mixing the pH regulator with the third mixed solution obtained in the step (2), and stirring to obtain a fourth mixed solution;
(4) and (3) mixing the rest of the antibacterial agent, the fourth mixed solution obtained in the step (3) and the liposome-containing anti-aging skin care matrix in the claim 1 or 2 to obtain the anti-aging essence cream.
8. The method according to claim 7, wherein the mixing of the first mixed solution in the step (1) is performed at 80 to 85 ℃;
preferably, the mixing of the first mixed solution in the step (1) further comprises a heat preservation operation, wherein the heat preservation time is 5-20 min;
preferably, the mixing of the second mixed solution in the step (1) is carried out at 85-90 ℃;
preferably, the mixing of the second mixed solution in the step (1) further comprises a heat preservation operation, and the heat preservation time is 5-20 min.
9. The method according to claim 7 or 8, wherein the time for the homogenization in the step (2) is 1-5min, and the homogenization speed is 8000-10000 rpm;
preferably, the mixing of step (3) is carried out at 50-70 ℃;
preferably, the mixing of step (4) is carried out at 30-45 ℃.
10. The method of any one of claims 7-9, comprising the steps of:
(1) mixing the softening agent, part of the emulsifier and the antioxidant at 80-85 ℃, and keeping the temperature for 5-20min to obtain a first mixed solution; mixing the anti-allergic agent, water, humectant, chelating agent, residual emulsifier and part of the antibacterial agent at 85-90 deg.C, and keeping the temperature for 5-20min to obtain a second mixed solution;
(2) mixing the first mixed solution and the second mixed solution obtained in the step (1), and homogenizing at the speed of 8000-;
(3) mixing a pH regulator with the third mixed solution obtained in the step (2) at 50-70 ℃, and stirring to obtain a fourth mixed solution;
(4) and (3) mixing the rest of the antibacterial agent, the fourth mixed solution obtained in the step (4) and the liposome-containing anti-aging skin-care matrix of claim 1 or 2 at the temperature of 30-45 ℃ to obtain the anti-aging essence cream.
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