CN113575595B

CN113575595B - Pesticide composition, preparation and application thereof

Info

Publication number: CN113575595B
Application number: CN202111036316.2A
Authority: CN
Inventors: 陈坤; 郑凯; 刘润峰; 陆建才; 于斌; 张瑜
Original assignee: Shanghai Mingdelida Biotechnology Co ltd
Current assignee: Yunfa Biotechnology Shanghai Co ltd
Priority date: 2021-09-06
Filing date: 2021-09-06
Publication date: 2022-05-10
Anticipated expiration: 2041-09-06
Also published as: CN113575595A

Abstract

The invention discloses a pesticide composition, and a preparation and application thereof. The active ingredients of the pesticide composition comprise chlorantraniliprole, metalaxyl-M and fluopyram, wherein the weight ratio of the chlorantraniliprole to the metalaxyl-M to the fluopyram is 1: (0.1-5): (0.1-5). Compared with a single pesticide active component, the pesticide composition has an obvious synergistic effect, can prevent and treat various different plant insect pests which are generated in a mixed mode, reduces the dosage, saves the cost and improves the safety to the environment.

Description

Pesticide composition, preparation and application thereof

Technical Field

The invention relates to the field of pesticides, in particular to a pesticide composition, a preparation and an application thereof, and particularly relates to a composition containing chlorantraniliprole, metalaxyl-M and fluopyram, a preparation and an application thereof.

Background

In the agricultural production process of China, long-term continuous cropping is a conventional production mode, and pests in soil are seriously accumulated. The existing commonly used pesticides have the main disadvantages of high toxicity and prominent resistance and residue problems.

Fluopyram is the British name for Fluopyram and N- [2- [ 3-chloro-5- (trifluoromethyl) -2-pyridine as the chemical name]Ethyl radical]-2- (trifluoromethyl) benzamide of the formula C₁₆H₁₁ClF₆N₂O, relative molecular weight 396.715, CAS No.: 658066-35-4, the structural formula is as follows:

fluopyram is a succinate dehydrogenase inhibitor (SDHI) type sterilization nematicide developed by Bayer crop science, is used for preventing and controlling alternaria leaf spot, gray mold, powdery mildew, sclerotinia, early blight and the like on vegetables such as grapes, pear trees, bananas, apples, cucumbers, tomatoes, field crops and the like, can be registered on various crops for preventing and controlling various nematodes, and is a high-efficiency, green and low-toxicity nematicide.

Common english name of chlorantraniliprole: chlorantraniliprole, chemical name: 3-bromo-N- [ 4-chloro-2-methyl-6- (methylcarbamoyl) benzene]-1- (3-chloropyridin-2-yl) -1H-pyrazole-5-carboxamide of formula C₁₈H₁₄BrCl₂N₅O₂Relative molecular weight: 483.15, CAS number 500008-45-7, which has the following structural formula:

the chlorantraniliprole is an o-formamido benzamide pesticide, is mainly used for controlling lepidoptera pests of various crops, has good control effect on noctuidae, snout moth family, moth-eating family, leaf-curling family, pink moth family, plutella xylostella family and the like of lepidoptera, and can also control various non-lepidoptera pests of coleoptera, curculidae, bimaculata family, bemisia tabaci and the like;

common english name of metalaxyl-M: Metalalxyl-M, chemical name: n- (2, 6-xylyl) -N- (methoxyacetyl) -D-alanine methyl ester with molecular formula C₁₅H₂₁NO₄Relative molecular weight: 279.33 CAS number 70630-17-0, having the following structural formula:

metalaxyl-M is an anilide bactericide and has high efficiency on diseases of vegetables, fruit trees, tobacco, oil plants, cotton, grains and other crops caused by peronospora parasitica, phytophthora parasitica and pythium.

In agricultural production practice there is often a problem of a mix of different types of pests, which may often be present simultaneously or in succession during the seed stage.

The search for suitable pesticidal compositions for controlling pests and reducing the development of pesticide resistance is the direction of research by those skilled in the art. Through intensive research, the inventor of the application explores a ternary composition containing chlorantraniliprole, metalaxyl-M and fluopyram, and the ternary composition has a synergistic control effect on agricultural pests.

Disclosure of Invention

The invention aims at providing a ternary composition containing chlorantraniliprole, metalaxyl-M and fluopyram, which has synergistic control effect on plant pests, particularly nematodes and grubs.

In order to realize the purpose of the invention, the technical scheme is as follows: a pesticide composition is characterized by comprising chlorantraniliprole, metalaxyl-M and fluopyram, wherein the weight ratio of the chlorantraniliprole to the metalaxyl-M to the fluopyram is 1: (0.1-5): (0.1-5).

The weight ratio of chlorantraniliprole, metalaxyl-M and fluopyram in the composition is 1: (0.2-3.5): (0.4-3.5).

The pesticide composition also contains an auxiliary agent, wherein the auxiliary agent is preferably one or more of a dispersing agent, a wetting agent, an emulsifier, a solvent, a cosolvent, an antifreezing agent, a stabilizer, a preservative, a thickening agent, a binder, a defoaming agent, a wall material, an acid adjusting medium, an alkali adjusting medium, a solid inert carrier, a film forming agent and a warning color.

The content of the active ingredients in the composition is 1-80 wt%, preferably 5-40 wt%, and more preferably 10-20 wt%.

The pesticide composition can be prepared into a proper dosage form on pesticides, and the dosage form can be one of a seed treatment microcapsule suspension-suspending agent, a seed treatment suspending emulsion and seed treatment wettable powder.

The pesticide composition can be used for preventing and treating insect pests on crops by seed treatment, wherein the crops refer to peanut, corn, rice, soybean and wheat.

The pesticide composition can mainly prevent and control the pests in seedling stage, wherein the pests are root-rot nematodes and grubs.

The invention has at least the following beneficial effects:

compared with single-component chlorantraniliprole, fluopyram, and two-component chlorantraniliprole and fluopyram, the seed coating composition of the invention increases metalaxyl-M, so that the seed coating composition has obvious synergistic effect and can improve the control effect; can prevent and control various plant diseases and insect pests which are mixed, thereby reducing the dosage, saving the cost and improving the safety to the environment.

Detailed Description

In order to make the objects, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below, and it is obvious that the described embodiments are a part of the embodiments of the present invention, but not all of the embodiments.

Throughout the specification and claims, unless expressly stated otherwise, the term "comprise" or variations such as "comprises" or "comprising" and the like are to be understood as including the stated elements but not excluding other active ingredients or adjuvants present.

In the present invention, "weight ratio" is equivalent to the conventional "mass ratio", and "wt" in the present invention means weight. The "drug-to-drug ratio" in the invention refers to the weight and/or mass ratio of the dosage of the pesticide product to the dosage of the plant seeds, and the "drug-to-drug ratio" in the invention refers to the weight and/or mass ratio of the pesticide and water.

The applicant researches and discovers that if the weight ratio of the chlorantraniliprole to the fluopyram is too large, namely the weight ratio of the fluopyram is too small, the insecticidal effect of the fluopyram on nematode pests cannot be fully exerted, and the pesticide effect is influenced; if the weight ratio of the chlorantraniliprole to the fluopyram is too small, namely the weight ratio of the chlorantraniliprole to the fluopyram is too small, the insecticidal effect of the chlorantraniliprole on lepidoptera and non-lepidoptera insect pests cannot be exerted, and the pesticide effect is influenced, so that the ratio of the chlorantraniliprole to the fluopyram is proper. Under the condition of compounding chlorantraniliprole and fluopyram, metalaxyl-M is added in a proper proportion, so that the insecticidal effect of the chlorantraniliprole and the fluopyram can be effectively improved, and the obvious synergistic effect is achieved

Researches show that the weight ratio of chlorantraniliprole, metalaxyl-M and fluopyram in the pesticide composition is 1: 0.1-5: 0.1 to 5. Preferably 1: (0.2-3.5): (0.4-3.5), most preferably 1: 0.2: 0.4,1: 1.5: 1.5,1: 1.25: 1.75,1: 1.33: 3,1: 3: 1.33,1: 3.5: 3.5, in the proportion range, the pesticide composition has good synergistic effect.

The pesticide composition further comprises an auxiliary agent, wherein the auxiliary agent is preferably one or more of a dispersing agent, a wetting agent, an emulsifier, a solvent, a cosolvent, an antifreezing agent, a stabilizer, a preservative, a thickening agent, a binder, a defoaming agent, a wall material, an acid adjusting medium, a base adjusting medium, a solid inert carrier, a film forming agent and a warning color.

Optionally, the dispersant is selected from sulfonate salts including bis (alkyl) naphthalene sulfonate formaldehyde condensate, octylphenol polyoxyethylene ether sulfate, aryl phenol polyoxyethylene succinate sulfonate, naphthalene sulfonate formaldehyde condensate; a polycarboxylate; sodium lignosulfonate; alkyl phenol polyoxyethylene ether formaldehyde condensate sulfate; calcium alkyl benzene sulfonate salts; naphthalenesulfonic acid formaldehyde condensate sodium salt; the vinyl ethers include one or more of alkylphenol ethoxylates, fatty acid polyoxyethylene esters, fatty amine polyoxyethylene ethers and ester polyoxyethylene ethers, preferably one or more of sulfonates, polycarboxylates and sodium lignosulfonates.

Optionally, the wetting agent is selected from one or more of sodium dodecyl sulfate, sodium lauryl sulfate, sodium dodecyl benzene sulfonate, nekal BX, tea seed cake, and fructus Gleditsiae Abnormalis powder. One or more of sodium dodecyl sulfate, sodium dodecyl benzene sulfonate and sodium lauryl sulfate are preferred.

Alternatively, the emulsifier may be one or more of a cationic surfactant, an anionic surfactant, a nonionic surfactant and a zwitterionic surfactant, and emulsifiers generally used for liquid formulations may be used. Preferably, the emulsifier is one or more of calcium dodecylbenzene sulfonate, polyethylene glycol fatty acid ester, sodium succinate, sorbitan trioleate, styryl phenol polyoxyethylene ether phosphate, benzyl phenol polyoxyethylene ether phosphate, sorbitan tristearate, polyoxyethylene sorbitan hexastearate, polyoxyethylene sorbitol beeswax derivatives, fatty alcohol polyoxyethylene ether, polyethylene glycol monostearate, castor oil polyoxyethylene ether, sorbitan sesquioleate, sorbitan monooleate, sorbitan monostearate, polyoxyethylene sorbitan monooleate, styryl phenol polyoxyethylene ether, glycerol monostearate and fatty amine polyoxyethylene ether, preferably one or more of sorbitan trioleate and sorbitan tristearate.

Alternatively, the solvent may be one or more of dichloromethane, xylene, aromatic mineral spirits and methyl oleate, preferably one or more of dichloromethane and aromatic mineral spirits.

Optionally, the cosolvent may be one or more of methanol, ethanol, dimethyl sulfoxide, N-methyl pyrrolidone, sulfolane, and ethyl acetate.

Optionally, the antifreeze can be one or more of ethylene glycol, 1, 2-propylene glycol and glycerol, preferably ethylene glycol.

Optionally, the binder may be one or more of starch, gum arabic, gypsum, glucose, polyvinyl alcohol, preferably starch.

Optionally, the thickener may be one or more of xanthan gum, magnesium aluminum silicate, polyethylene glycol, polyvinyl alcohol, carboxymethyl cellulose, preferably one or more of magnesium aluminum silicate, xanthan gum.

Optionally, the solid inert carrier may be one or more of kaolin, clay, silica, bentonite, diatomaceous earth, montmorillonite, talc and precipitated calcium carbonate, preferably one or more of silica, diatomaceous earth and kaolin.

Optionally, the defoaming agent is selected from one or more of silicones, fatty alcohols, saturated fatty acids (such as capric acid), amides, and silicone compounds. Silicones are preferred.

Optionally, the wall material is selected from one or more of polyureas, polyurethanes, melamine resins and mixed polyureas/polyamides, gelatin/gum arabic, polyamides, preferably polyamides.

Optionally, the acid adjusting medium is selected from one or more of phosphoric acid, hydrochloric acid, citric acid, formic acid, acetic acid and acetic acid.

Optionally, the alkali adjusting medium is selected from one or more of sodium hydroxide, triethanolamine, triethylamine and ammonia water.

Optionally, the preservative is selected from sodium benzoate. The stabilizer may be any one commonly used in the art, and is well known to those skilled in the art and will not be described herein.

Optionally, the film forming agent comprises at least one of acacia, polyethylene glycol, methylcellulose, sodium carboxymethylcellulose, polyvinyl alcohol, ethylcellulose, polyacrylamide, sodium polyacrylate, polysaccharide high molecular compounds and cellulose derivatives.

Optionally, the color paste may comprise at least one of red and blue water-soluble color pastes.

In one embodiment, the content of the active ingredient in the pesticide composition of the present invention is 1 to 80 wt%, preferably 5 to 40 wt%, and more preferably 10 to 20 wt%.

The seed treatment pesticidal composition of the present invention may be provided in a finished form, i.e., the ingredients of the composition have been mixed; each component can also be provided in the form of a separate preparation, which is directly dressed at the time of use.

The embodiment of the invention also relates to seed coating agents prepared from the seed treatment pesticide composition, which are seed treatment microcapsule suspension-suspending agents, seed treatment suspending emulsions and seed treatment wettable powder.

The above-mentioned dosage forms have no special requirements for other components except for active component, and their contents and active component content, and can adopt the conventional proportioning in the field, for example:

the suspension-suspension agent for the seed treatment microcapsule generally comprises 5-50 wt% of active ingredients (wherein the weight fraction of free active ingredients accounts for less than 10% of the weight fraction of the active ingredients of the microcapsule), 1-10 wt% of wall materials, 0.5-10 wt% of dispersing agents, 0.5-5 wt% of wetting agents, 3-15 wt% of emulsifying agents, 0-20 wt% of solvents, 0.1-5 wt% of antifreezing agents, 0.4-4% of film forming agents, 4-12% of color pastes, 0-10 wt% of other additives such as stabilizers, preservatives, thickening agents, acid adjusting media, alkali adjusting media and the balance of water.

The seed treatment suspending agent generally comprises 3-60 wt% of active components, 1-10 wt% of dispersing agents, 0.5-5 wt% of wetting agents, 3-15 wt% of emulsifying agents, 0.1-10 wt% of anti-freezing agents, 0.4-4 wt% of film forming agents, 4-12 wt% of color pastes, 0-10 wt% of other additives such as stabilizers, preservatives, thickening agents, defoaming agents and the balance of water. Seed treatment suspensions typically require wet milling to obtain a stable, flowable, easily measured volume of the suspension liquid.

The seed treatment suspoemulsion generally contains 3-70 wt% of active ingredients, 3-15 wt% of emulsifiers, 2-10 wt% of dispersants, 0-20 wt% of solvents, 0.1-2 wt% of thickeners, 0.1-8 wt% of anti-freezing agents, 0.05-3 wt% of stabilizers, 0.4-4 wt% of film forming agents, 4-12 wt% of color pastes, 0.2-1 wt% of defoaming agents and the balance of water.

The seed treatment wettable powder usually contains 3-95 wt% of active components, 0.5-10 wt% of dispersing agents, 0.5-5 wt% of wetting agents, 0.4-4 wt% of film forming agents, 4-12 wt% of toner, 0-10 wt% of other additives such as stabilizing agents and the like, and the balance of solid inert carriers such as kaolin and the like.

In the present invention, there is no special requirement for the preparation method of various dosage forms, and various methods known in the art can be adopted, and are not described herein again.

The pesticide composition can be prepared into seed coating agents for preventing and treating insect pests on peanut, corn, rice, soybean and wheat in seedling stage.

The invention also relates to the application of the seed coating agent in pest control treatment on seedling stages of peanuts, corns, rice, soybeans and wheat, such as controlling pests of wireworms, root rot nematodes, grubs and the like.

In the following, the present invention is illustrated in more detail with reference to examples, which, however, are not to be construed in any way as limiting the scope of the invention.

Preparation example (A)

Example 116% seed treatment of chlorantraniliprole, metalaxyl-M and fluopyram microcapsule suspension-suspension concentrate, the weight ratio of chlorantraniliprole, metalaxyl-M and fluopyram is 10: 2: 4 (i.e., 1: 0.2: 0.4).

10 wt% of chlorantraniliprole, 2 wt% of metalaxyl-M, 4 wt% of fluopyram, 3 wt% of aryl phenol polyoxyethylene succinate sulfonate, 2 wt% of sodium dodecyl sulfate, 5 wt% of sorbitan tristearate, 10 wt% of dichloromethane, 2 wt% of polyamide, 0.2 wt% of xanthan gum, 0.5 wt% of magnesium aluminum silicate, 0.2 wt% of organic silicon defoamer, 4 wt% of ethylene glycol, 0.2 wt% of sodium benzoate, 0.4% of polyvinyl alcohol, 12% of red soluble color paste and water added to 100 wt%.

Example 216% seed treatment microcapsule suspension-suspension formulation of chlorantraniliprole, metalaxyl-M and fluopyram, the weight ratio of chlorantraniliprole, metalaxyl-M and fluopyram is 4: 6: 6 (i.e., 1: 1.5: 1.5).

4 wt% of chlorantraniliprole, 6 wt% of metalaxyl-M, 6 wt% of fluopyram, 3 wt% of aryl phenol polyoxyethylene succinate sulfonate, 2 wt% of sodium dodecyl sulfate, 5 wt% of sorbitan tristearate, 10 wt% of dichloromethane, 2 wt% of polyamide, 0.2 wt% of xanthan gum, 0.5 wt% of magnesium aluminum silicate, 0.2 wt% of organic silicon defoamer, 4 wt% of ethylene glycol, 0.2 wt% of sodium benzoate, 0.4% of polyvinyl alcohol, 12% of red soluble color paste and water added to 100 wt%.

Example 316% seed treatment of chlorantraniliprole, metalaxyl-M and fluopyram microcapsule suspension-suspension concentrate, the weight ratio of chlorantraniliprole, metalaxyl-M and fluopyram is 4: 5: 7 (i.e., 1: 1.25: 1.75).

4 wt% of chlorantraniliprole, 5 wt% of metalaxyl-M, 7 wt% of fluopyram, 3 wt% of aryl phenol polyoxyethylene succinate sulfonate, 2 wt% of sodium dodecyl sulfate, 5 wt% of sorbitan tristearate, 10 wt% of dichloromethane, 2 wt% of polyamide, 0.2 wt% of xanthan gum, 0.5 wt% of magnesium aluminum silicate, 0.2 wt% of organic silicon defoamer, 4 wt% of ethylene glycol, 0.2 wt% of sodium benzoate, 0.4% of polyvinyl alcohol, 12% of red soluble color paste and water added to 100 wt%.

Example 416% seed treatment suspension of chlorantraniliprole, metalaxyl-M and fluopyram in a weight ratio of 3: 4: 9 (i.e., 1: 1.33: 3).

3 wt% of chlorantraniliprole, 4 wt% of metalaxyl-M, 9 wt% of fluopyram, 3 wt% of alkylphenol polyoxyethylene, 2 wt% of sodium lignosulfonate, 0.2 wt% of xanthan gum, 0.5 wt% of magnesium aluminum silicate, 0.2 wt% of organic silicon defoamer, 4 wt% of ethylene glycol, 0.2 wt% of sodium benzoate, 0.4% of polyvinyl alcohol, 12% of red soluble color paste and water added to 100 wt%.

Example 516% seed treatment suspoemulsion of chlorantraniliprole, metalaxyl-M and fluopyram in a weight ratio of 3: 9: 4 (i.e., 1: 3: 1.33).

3 wt% of chlorantraniliprole, 9 wt% of metalaxyl-M, 4 wt% of fluopyram, 3 wt% of alkylphenol polyoxyethylene, 2 wt% of sodium lignosulfonate, 5 wt% of sorbitan tristearate, 10 wt% of aromatic hydrocarbon solvent oil, 0.2 wt% of xanthan gum, 0.5 wt% of magnesium aluminum silicate, 0.2 wt% of organic silicon defoamer, 4 wt% of ethylene glycol, 0.2 wt% of sodium benzoate, 0.4% of polyvinyl alcohol, 12% of red soluble color paste and water added to 100 wt%.

Example 616% wettable powder for seed treatment of chlorantraniliprole, metalaxyl-M and fluopyram, the weight ratio of chlorantraniliprole, metalaxyl-M and fluopyram being 2: 7: 7 (i.e., 1: 3.5: 3.5).

2 wt% of chlorantraniliprole, 7 wt% of metalaxyl-M, 7 wt% of fluopyram, 10 wt% of alkyl naphthalene sulfonate, 5 wt% of sodium dodecyl sulfate, 0.4% of polyvinyl alcohol, 5% of red toner and 100 wt% of kaolin.

Comparative example 116% Chlorantraniliprole seed treatment suspension

16 wt% of chlorantraniliprole, 3 wt% of aryl phenol polyoxyethylene succinate sulfonate, 2 wt% of sodium dodecyl sulfate, 0.2 wt% of xanthan gum, 0.5 wt% of magnesium aluminum silicate, 0.2 wt% of organic silicon defoamer, 5 wt% of ethylene glycol, 0.2 wt% of sodium benzoate, 0.4% of polyvinyl alcohol, 12% of red soluble color paste and water added to 100 wt%.

Comparative example 216% metalaxyl-M seed treatment suspension

16 wt% of metalaxyl-M, 3 wt% of aryl phenol polyoxyethylene succinate sulfonate, 1 wt% of clethodim, 2 wt% of sodium dodecyl sulfate, 5 wt% of sorbitan tristearate, 10 wt% of dichloromethane, 2 wt% of polyamide, 0.2 wt% of xanthan gum, 0.2 wt% of organic silicon defoamer, 5 wt% of ethylene glycol, 0.2 wt% of sodium benzoate, 0.4% of polyvinyl alcohol, 12% of red soluble color paste and water added to 100 wt%.

Comparative example 316% Fluopyram seed treatment suspension

16 wt% of fluopyram, 3 wt% of aryl phenol polyoxyethylene succinate sulfonate, 2 wt% of sodium dodecyl sulfate, 0.2 wt% of xanthan gum, 0.5 wt% of magnesium aluminum silicate, 0.2 wt% of organic silicon defoamer, 5 wt% of ethylene glycol, 0.2 wt% of sodium benzoate, 0.4% of polyvinyl alcohol, 12% of red soluble color paste and 100 wt% of water

Comparative example 416% chlorantraniliprole and fluopyram seed treatment suspension, the weight ratio of chlorantraniliprole to fluopyram is 10: 6 (i.e. 1: 0.6)

10 wt% of chlorantraniliprole, 6 wt% of fluopyram, 3 wt% of aryl phenol polyoxyethylene succinate sulfonate, 2 wt% of sodium dodecyl sulfate, 0.2 wt% of xanthan gum, 0.5 wt% of magnesium aluminum silicate, 0.2 wt% of an organic silicon defoamer, 5 wt% of ethylene glycol, 0.2 wt% of sodium benzoate, 0.4% of polyvinyl alcohol, 12% of red soluble color paste and water added to 100 wt%.

Comparative example 516% metalaxyl-M and fluopyram seed treatment microcapsule suspension-suspension formulation, the weight ratio of metalaxyl-M and fluopyram is 10: 6 (i.e. 1: 0.6)

10 wt% of metalaxyl-M, 6 wt% of fluopyram, 3 wt% of aryl phenol polyoxyethylene succinate sulfonate, 2 wt% of sodium dodecyl sulfate, 5 wt% of sorbitan tristearate, 10 wt% of dichloromethane, 2 wt% of polyamide, 0.2 wt% of xanthan gum, 0.5 wt% of magnesium aluminum silicate, 0.2 wt% of organic silicon defoamer, 5 wt% of ethylene glycol, 0.2 wt% of sodium benzoate, 0.4% of polyvinyl alcohol, 12% of red soluble color paste and water added to 100 wt%.

Comparative example 616% chlorantraniliprole and metalaxyl-M seed treatment microcapsule suspension-suspending agent, the weight ratio of chlorantraniliprole to metalaxyl-M being 8: 8 (i.e. 1: 1)

8 wt% of chlorantraniliprole, 8 wt% of metalaxyl-M, 3 wt% of aryl phenol polyoxyethylene succinate sulfonate, 2 wt% of sodium dodecyl sulfate, 5 wt% of sorbitan tristearate, 10 wt% of dichloromethane, 2 wt% of polyamide, 0.2 wt% of xanthan gum, 0.5 wt% of magnesium aluminum silicate, 0.2 wt% of an organic silicon defoamer, 5 wt% of ethylene glycol, 0.2 wt% of sodium benzoate, 0.4% of polyvinyl alcohol, 12% of red soluble color paste and water added to 100 wt%.

Comparative example 716% seed treatment microcapsule suspension-suspension formulation of chlorantraniliprole, metalaxyl-M and fluopyram, the weight ratio of chlorantraniliprole, metalaxyl-M and fluopyram being 14.5: 0.75: 0.75 (i.e., 1: 0.052: 0.052).

14.5 percent of chlorantraniliprole, 0.75 percent of metalaxyl-M, 0.75 percent of fluopyram, 3 percent of aryl phenol polyoxyethylene succinate sulfonate, 2 percent of sodium dodecyl sulfate, 5 percent of sorbitan tristearate, 10 percent of dichloromethane, 2 percent of polyamide, 0.2 percent of xanthan gum, 0.5 percent of magnesium aluminum silicate, 0.2 percent of organic silicon defoamer, 5 percent of glycol, 0.2 percent of sodium benzoate, 0.4 percent of polyvinyl alcohol, 12 percent of red soluble color paste and water added to 100 percent.

Comparative example 816% seed treatment microcapsule suspension-suspension formulation of chlorantraniliprole, metalaxyl-M and fluopyram, the weight ratio of chlorantraniliprole, metalaxyl-M and fluopyram is 0.7: 7.65: 7.65 (i.e., 1: 10.9: 10.9).

0.7 wt% of chlorantraniliprole, 7.65 wt% of metalaxyl-M, 7.65 wt% of fluopyram, 3 wt% of aryl phenol polyoxyethylene succinate sulfonate, 2 wt% of sodium dodecyl sulfate, 5 wt% of sorbitan tristearate, 10 wt% of dichloromethane, 2 wt% of polyamide, 0.2 wt% of xanthan gum, 0.5 wt% of magnesium aluminum silicate, 0.2 wt% of organic silicon defoamer, 5 wt% of ethylene glycol, 0.2 wt% of sodium benzoate, 0.4% of polyvinyl alcohol, 12% of red soluble color paste and water added to 100 wt%.

The compositions of the active ingredients in examples 1 to 6 and comparative examples 1 to 8 are specifically shown in table 1:

TABLE 1

II) biological test

1. Screening of indoor bioassay tests

Indoor toxicology determination of root rot nematodes:

(1) reagent to be tested:

chlorantraniliprole (purchased from Shandong Weifang Runfeng chemical Co., Ltd.)

Fluopyram (from Bayer AG)

metalaxyl-M (from Emodao Maihuifeng GmbH)

(2) The test method comprises the following steps: the corn roots which are artificially inoculated with the root-rot nematodes are picked and mashed by a tissue masher, are sequentially screened by nematode standard sieves of 200 meshes, 300 meshes and 500 meshes, and eggs on the nematode sieve of 500 meshes are washed by sterile water to prepare an egg suspension (10 eggs/mL). And (3) hatching another part of eggs in sterile water, taking larvae (larvae of 2 years old) hatched in the next day for testing, and testing the toxicity of chlorantraniliprole, fluopyram and metalaxyl-M with different proportions to nematode larvae or egg suspension (10 nematodes/mL or 10 eggs/mL, the relative humidity is 80-90%, the culture is carried out at the temperature of 23-26 ℃, clear water is used as a control, and the process is repeated for three times per treatment).

(3) Data analysis

The co-toxicity coefficient (CTC value) of various compound agents is determined by adopting an indoor toxicity determination method (according to the Sun Yunpei method) and through indoor toxicity determination, and the synergy of the agents is judged according to the CTC value. CTC is remarkably greater than 100, is synergistic, remarkably less than 100, is antagonistic, and is close to 100, is additive. However, in the actual production process, once thought, the synergistic effect is achieved when the CTC is more than or equal to 120, the antagonistic effect is achieved when the CTC is less than or equal to 80, the additive effect is achieved when the CTC is more than 80 and less than 120, and the obvious synergistic effect is achieved when the CTC is more than or equal to 200.

Actual toxicity index ATI ═ standard medicament LD₅₀Mixed medicine LD₅₀*100

Virulence index TTI ═ Standard agent LD₅₀Test agent LD₅₀*100

Theoretical virulence index TTI (standard agent virulence index) percentage of standard agent in mixed composition + test agent virulence index

Co-toxicity coefficient CTC ═ ATI/TTI ═ 100

(4) Results and discussion

TABLE 2 indoor toxicity determination of chlorantraniliprole and fluopyram and metalaxyl-M on root-rot nematodes

TABLE 2

From table 2, it can be seen that the weight ratio of chlorantraniliprole, metalaxyl-M and fluopyram is 1: 0.2: 0.4,1: 1.5: 1.5,1: 1.25: 1.75,1: 1.33: 3,1: 3: 1.33,1: 3.5: 3.5, the composition has better synergistic effect.

2. Effect of field test

2.1 run 1

The final products obtained in examples 1 to 6 and comparative examples 1 to 8 were used as samples to test the effects of the samples on the golden thread worms and the golden thread worms of peanuts.

Test site: hebei province, Shijiazhuang city. The plot has good fertility, fine management, seed dressing treatment before sowing, 200-250 g of medicament per 100kg of seeds, and the ratio of the liquid to the medicament is 1: and 5, sowing after airing, and normally managing after sowing.

In the test, the final products obtained in examples 1 to 6 and comparative examples 1 to 8 were mixed with water in appropriate amounts, the seeds were mixed with water in the same amount in blank control, each treatment was repeated 3 times, 45 cells were planted in total, and each cell was a square meter of 66.7 meters, and the cells were randomly arranged.

And (3) investigating the occurrence conditions of golden nematodes and wireworms 10d, 30d and 60d after peanut emergence, randomly sampling at 5 points in each treatment area, investigating 30 plants in each cell, digging the depth of seedlings to be 30cm, investigating the population base number before pesticide application, investigating the number of residual worms 30 days after pesticide application, and calculating the control effect.

Prevention and cure (PT)_{Rate of oral polyp decline}-CK_{Rate of oral polyp decline})/(100-CK_{Rate of oral cavity decline})×100；

In the formula: CK-placebo incidence;

PT-incidence in treatment area.

TABLE 3 test of the control efficiency of the samples on golden thread and golden yellow insects

TABLE 3

2.2 test example 2

The final products obtained in examples 1 to 6 and comparative examples 1 to 8 were used as samples for testing the effects on corn root rot nematodes and white grubs in the present test example.

Test site: sublingum city of Heilongjiang province. The plot has good fertility, fine management, seed dressing treatment before sowing, 200-250 g of medicament per 100kg of seeds, and the ratio of the liquid to the medicament is 1: and 5, normally managing after sowing.

Investigating the occurrence conditions of root rot nematodes and grubs 10d, 30d and 60d after emergence of the corn seedlings, randomly taking 5 points for each plot, taking 100 plants at each point, digging the seedling depth to be 30cm, investigating the population base number before the pesticide, investigating the number of residual insects 10d, 30d and 60d after the pesticide, and calculating the control effect.

Control effect (PT)_{Rate of oral polyp decline}-CK_{Rate of oral cavity decline})/(100-CK_{Rate of oral cavity decline})×100；

In the formula: CK-placebo incidence;

PT-incidence in treatment area.

TABLE 4 test of the control effect of the samples on root-rot nematodes and grubs on corn

TABLE 4

As can be seen from tables 3 and 4, the pesticide composition of the invention has good control effect relative to single-component chlorantraniliprole, metalaxyl-M and fluopyram, and has better effect relative to double-component chlorantraniliprole, fluopyram, metalaxyl-M, chlorantraniliprole, metalaxyl-M and fluopyram, and the pesticide composition of the invention has the advantages of expanding insecticidal range and synergism.

As can be seen from tables 3 and 4, when examples 2 to 3 are compared with examples 4 to 6, respectively, the seed-treated microcapsule suspension-suspension formulations of chlorantraniliprole, metalaxyl-M and fluopyram are more effective and preferable than other formulations.

The pesticide composition has obvious synergistic effect and high preventing and treating effect. Thereby reducing the dosage, saving the cost and lightening the pollution to the environment.

Finally, it should be noted that: the above examples are only intended to illustrate the technical solution of the present invention, but not to limit it; although the present invention has been described in detail with reference to the foregoing embodiments, it will be understood by those of ordinary skill in the art that: the technical solutions described in the foregoing embodiments may still be modified, or some technical features may be equivalently replaced; and such modifications or substitutions do not depart from the spirit and scope of the corresponding technical solutions of the embodiments of the present invention.

Claims

1. A pesticide composition is characterized by comprising chlorantraniliprole, metalaxyl-M and fluopyram, wherein the weight ratio of the chlorantraniliprole to the metalaxyl-M to the fluopyram is 1: (0.2-3.5): (0.4-3.5).

2. The pesticide composition as set forth in claim 1, further comprising an adjuvant, wherein the adjuvant is one or more of a dispersant, a wetting agent, an emulsifier, a solvent, a cosolvent, an antifreeze, a stabilizer, a preservative, a thickener, a binder, a defoamer, a wall material, an acid adjusting medium, a base adjusting medium, a solid inert carrier, a film forming agent and a warning color.

3. The pesticide composition as set forth in claim 2, wherein the chlorantraniliprole, metalaxyl-M and fluopyram are contained in an amount of 1 to 80 wt%.

4. The pesticide composition as claimed in claim 3, wherein the content of chlorantraniliprole, metalaxyl-M and fluopyram is preferably 5-40 wt%.

5. The pesticide composition as set forth in claim 4, wherein the chlorantraniliprole, metalaxyl-M and fluopyram are contained in an amount of 10 to 20 wt%.

6. The pesticidal composition according to any one of claims 1 to 5, characterized in that it is formulated into a pesticidally suitable dosage form, which may be one of a seed treatment microcapsule suspension-suspending agent, a seed treatment suspoemulsion, a seed treatment wettable powder.

7. Use of a pesticidal composition according to any one of claims 1 to 6, characterised in that the control of pests on crops is effected by seed treatment.

8. The use of claim 7, wherein the crop is selected from the group consisting of peanut, corn, rice, soybean, wheat.

9. Use according to claim 8, characterized in that it is used for controlling seedling pests.

10. The use according to claim 9, characterized in that the pests are root-rot nematodes, grubs.