CN113509646A

CN113509646A - Electrode patch, cell division inhibition device and control method thereof

Info

Publication number: CN113509646A
Application number: CN202110932818.7A
Authority: CN
Inventors: 衷兴华; 杨克; 汪龙
Original assignee: Hangzhou Vena Anke Medical Technology Co Ltd
Current assignee: Hangzhou Vena Anke Medical Technology Co ltd
Priority date: 2021-08-13
Filing date: 2021-08-13
Publication date: 2021-10-19

Abstract

The embodiment of the application provides an electrode patch, a cell division inhibition device and a control method thereof. The electrode patch includes: the flexible circuit board, and a capacitor and an electrode which are respectively connected with the flexible circuit board; the first pole of the capacitor is used for being electrically connected with a power supply through the flexible circuit board; the second pole of the capacitor is electrically connected with the electrode through the flexible circuit board; the electrodes are used to output a target electric field to the target tissue. The embodiment of the application realizes that the dielectric material in the electrode patch is replaced by the capacitor, and the electric field can be directly formed under the combined action of the capacitor and the electrode to act on biological tissues so as to inhibit the division of tumor cells; compared with the mode that adopts dielectric material equivalence to be the electric field of electric capacity among the prior art, the electrode paster that this application provided has reduced the energy consumption that the in-process of output electric field produced, has improved electric conduction efficiency to the poor problem of ceramic material thermal diffusivity has been avoided.

Description

Electrode patch, cell division inhibition device and control method thereof

Technical Field

The application relates to the technical field of medical equipment, in particular to an electrode patch, a cell division inhibition device and a control method thereof.

Background

Electric field tumor therapy is a more advanced tumor therapy technology. This technique is based on the biological property that cancer cells divide more frequently than normal cells, and forms a low-intensity, medium-frequency alternating-current electric field in such a way that the electrode patch is applied to the treatment site, acting on tubulin that proliferates cancer cells, interfering with mitosis of the tumor cells, causing apoptosis of the affected cancer cells and inhibiting tumor growth.

The electrode patch is used as an important device for tumor electric field treatment, and the structure of the electrode patch directly influences the performance of an electric field. However, the existing electrode patches usually adopt ceramic as a dielectric material, which is equivalent to a capacitive electric field. The defects of poor heat dissipation, high energy consumption of the dielectric material and the like caused by the fact that the dielectric material directly acts on a human body exist.

Disclosure of Invention

The application aims at the defects of the existing mode and provides an electrode patch, a cell division inhibiting device and a control method of the cell division inhibiting device, and the electrode patch, the cell division inhibiting device and the control method are used for solving the technical problems that in the prior art, the dielectric material directly acts on a human body to cause poor heat dissipation, or the energy consumption of the dielectric material is high and the like.

In a first aspect, embodiments of the present application provide an electrode patch, including:

the flexible circuit board, and the electric capacity and the electrode that are connected with flexible circuit board respectively.

The first pole of the capacitor is used for being electrically connected with a power supply through the flexible circuit board.

The second pole of the capacitor is electrically connected to the electrode through the flexible circuit board.

The electrodes are used to output a target electric field to the target tissue.

Optionally, the capacitors and the electrodes are electrically connected in a one-to-one correspondence.

And/or the capacitor and the electrode are both positioned on the same side of the flexible circuit board.

Alternatively, the flexible circuit board includes at least one pad portion, and a connection portion connecting adjacent two pad portions.

The electrode is electrically connected to one side of the pad portion.

The capacitor is electrically connected to one side of the connection portion.

Optionally, the electrode patch further comprises: a reinforcing sheet.

The reinforcing sheet is connected to the land portion on a side away from the electrode.

Optionally, the electrode patch further comprises: a medical adhesive tape.

The medical adhesive tape is connected with one side of the flexible circuit board far away from the electrode and is used for being at least partially attached to the surface of the target biological tissue.

Optionally, the electrode patch further comprises: the first release paper and the second release paper.

The first release paper and the second release paper are respectively connected with one side of the flexible circuit board, which is far away from the medical adhesive tape.

The projection of one part of the first release paper on the first plane is overlapped with one part of the projection of the medical adhesive tape on the first plane, and the projection of one part of the second release paper on the first plane is overlapped with the other part of the projection of the medical adhesive tape on the first plane; the first plane is parallel to the plane of the medical adhesive tape.

The projection of the other part of the first release paper on the second plane is at least partially overlapped with the projection of the other part of the second release paper on the second plane, and the second plane and the first plane form an acute angle or a right angle.

Optionally, the electrode patch further comprises: and (5) soaking cotton.

The foam is connected with one side of the flexible circuit board close to the capacitor, and at least partially covers the flexible circuit board.

The foam is provided with an electrode through hole and a capacitor through hole, the electrode through hole is embedded with the electrode, and the capacitor through hole is embedded with the capacitor.

Optionally, the electrode patch further comprises: a conductive hydrogel sheet.

The conductive hydrogel sheets are connected with one side of the electrode far away from the flexible circuit board, and each conductive hydrogel sheet at least partially covers the electrode.

In a second aspect, embodiments of the present application provide a cell-division inhibiting device, comprising: the electrode patch, the voltage generator and the controller as provided in the first aspect.

At least one pair of electrode patches as provided in the first aspect for application to a surface of a target biological tissue according to a predetermined pattern.

The voltage generator is electrically connected with at least one pair of electrode patches and is used for outputting voltage to each pair of electrode patches.

The controller is electrically connected with the voltage generator and the at least one pair of electrode patches and is used for controlling the voltage so as to adjust the strength and/or direction of the electric field of the at least one pair of electrode patches, so that each pair of electrode patches forms a target electric field at least surrounding target biological tissues.

Optionally, the voltage generator is a pulse voltage generator or an alternating voltage generator.

Optionally, each pair of electrode patches is for attachment to opposite sides of a biological tissue surface; the connecting line of any pair of electrode patches and the connecting line of the adjacent pair of electrode patches form an alpha angle, and alpha is more than 0 and less than 90 degrees.

In a third aspect, the present embodiments provide a method for controlling a cell division inhibiting device according to the second aspect, including:

and controlling a voltage generator in the cell division inhibiting device to output voltages to the electrode patches to form a target electric field at least surrounding the target biological tissue so as to inhibit at least part of the target cells from dividing or kill at least part of the target cells.

The beneficial technical effects brought by the technical scheme provided by the embodiment of the application comprise:

adopt electric capacity to replace dielectric material in the structure of the electrode paster that provides in this application, electric capacity and electrode pass through the flexible circuit electricity on the flexible circuit board and connect, and behind the switch on power, electric capacity and electrode combined action can directly form the electric field, act on biological tissue. Compared with the mode that adopts dielectric material equivalence to be the electric field of electric capacity among the prior art, the electrode paster that this application provided can reduce the energy consumption that the in-process of output electric field produced to electric capacity and electrode direct electrical connection have improved electric conduction efficiency, and have avoided the poor problem of ceramic material thermal diffusivity. The comfort level of the organism and the efficiency of the electric field output by the electrode patch during working are improved.

Additional aspects and advantages of the present application will be set forth in part in the description which follows and, in part, will be obvious from the description, or may be learned by practice of the present application.

Drawings

The foregoing and/or additional aspects and advantages of the present application will become apparent and readily appreciated from the following description of the embodiments, taken in conjunction with the accompanying drawings of which:

fig. 1 is a schematic diagram of an electrical connection between a capacitor and an electrode in an electrode patch according to an embodiment of the present disclosure;

fig. 2 is an exploded view of an electrode patch according to an embodiment of the present disclosure;

fig. 3 is a schematic view of a connection structure between a flexible circuit board and a capacitor in an electrode patch according to an embodiment of the present disclosure;

fig. 4 is a schematic diagram of a cell division suppressing apparatus according to an embodiment of the present disclosure.

In the figure:

1-a flexible circuit board; 11-a pad portion; 12-a connecting part;

2-an electrode; 3-capacitance; 4-medical adhesive tape;

5-soaking cotton; 51-electrode vias; 52-capacitive vias;

6-reinforcing sheet; 7-conductive hydrogel sheet;

8-first release paper; 9-second release paper;

100-a cell division inhibiting device;

110-a voltage generator; 120-electrode patch; 130-a controller.

Detailed Description

Reference will now be made in detail to the present application, examples of which are illustrated in the accompanying drawings, wherein like reference numerals refer to the same or similar parts or parts having the same or similar functions throughout. In addition, if a detailed description of the known art is not necessary for illustrating the features of the present application, it is omitted. The embodiments described below with reference to the drawings are exemplary only for the purpose of explaining the present application and are not to be construed as limiting the present application.

It will be understood by those within the art that, unless otherwise defined, all terms (including technical and scientific terms) used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this application belongs. It will be further understood that terms, such as those defined in commonly used dictionaries, should be interpreted as having a meaning that is consistent with their meaning in the context of the prior art and will not be interpreted in an idealized or overly formal sense unless expressly so defined herein.

As used herein, the singular forms "a", "an", "the" and "the" are intended to include the plural forms as well, unless the context clearly indicates otherwise. It will be further understood that the terms "comprises" and/or "comprising," when used in this specification, specify the presence of stated features, integers, steps, operations, elements, and/or components, but do not preclude the presence or addition of one or more other features, integers, steps, operations, elements, components, and/or groups thereof. It will be understood that when an element is referred to as being "connected" or "coupled" to another element, it can be directly connected or coupled to the other element or intervening elements may also be present. Further, "connected" or "coupled" as used herein may include wirelessly connected or wirelessly coupled. As used herein, the term "and/or" includes all or any element and all combinations of one or more of the associated listed items.

The inventors of the present application have studied and found that, in a conventional electrode patch, a dielectric material such as ceramic is generally used and is equivalent to a capacitive electric field. The equivalent electric field ceramic directly acts on the surface of the biological tissue, and has the problem of poor heat dissipation. The electrode patch can be pasted on the surface of the biological tissue for a long time in the process of tumor electric field treatment, and heat is continuously generated in the process of outputting an electric field by the electrode, so that the risk of scalding or burning the surface of the biological tissue is aggravated.

In addition, the energy loss in the electrode patch in the prior art comprises series resistance and dielectric material resistance, and the problem of excessive energy loss exists.

The application provides an electrode patch, a cell division inhibition device and a control method thereof, which aim to solve the technical problems in the prior art.

The following describes the technical solutions of the present application and how to solve the above technical problems with specific embodiments.

The embodiment of the present application provides an electrode patch 120, and a schematic structural diagram of the electrode patch 120 is shown in fig. 1, including but not limited to: a flexible circuit board 1, and a capacitor 3 and an electrode 2 respectively connected to the flexible circuit board 1.

A first pole of the capacitor 3 is used for electrical connection with a power supply via the flexible circuit board 1.

The second pole of the capacitor 3 is electrically connected to the electrode 2 via the flexible circuit board 1.

The electrodes 2 are used to output a target electric field to a target tissue.

In this embodiment, the electrode patch 120 is configured to replace a dielectric material with a capacitor, and the capacitor 3 is directly electrically connected to the electrode 2, so that dielectric loss of the dielectric material in the prior art can be avoided, and the utilization rate of energy can be improved. The heat dispersion of the capacitor 3 is good, heat is prevented from accumulating on one side of the electrode patch 120 close to the body surface, and the comfort level of the surface of the biological tissue is improved. In addition, the efficiency of the electric field output by the electrode 2 can be improved, and the division of tumor cells can be effectively inhibited.

Alternatively, the second pole of one capacitor 3 is electrically connected to the plurality of electrodes 2 through the flexible circuit board 1, wherein the one capacitor 3 is used for outputting an electric field to the plurality of electrodes 2.

Alternatively, the second poles of the plurality of capacitors 3 are electrically connected to one electrode 2 through the flexible circuit board 1, wherein the plurality of capacitors 3 are used for outputting an electric field to one electrode 2.

Alternatively, the second poles of the plurality of capacitors 3 are electrically connected to the plurality of electrodes 2 through the flexible circuit board 1, wherein the plurality of capacitors 3 are configured to output an electric field to the plurality of electrodes 2.

Alternatively, each capacitor 3 and each electrode 2 are electrically connected in a one-to-one correspondence, wherein each capacitor 3 is used for outputting an electric field to each assigned electrode 2.

Alternatively, the capacitor 3 and the electrode 2 may be connected to the flexible circuit board 1 by crimping, welding or wire-wrapping. Fig. 3 is a schematic diagram illustrating a connection manner of the capacitor 3 and the flexible circuit board 1.

Alternatively, as shown in fig. 2, the capacitor 3 and the electrode 2 are both located on the same side of the flexible circuit board 1.

Alternatively, the capacitor 3 and the electrode 2 are respectively located on both sides of the flexible circuit board 1.

Alternatively, as shown in fig. 2, the flexible circuit board 1 includes at least one pad portion 11, and a connection portion 12 connecting adjacent two pad portions 11. The electrode 2 is electrically connected to one side of the pad portion 11, and the capacitor 3 is electrically connected to one side of the connection portion 12. Wherein the pad portions 11 are used to output an electric field, and the connection portions 12 are used to supply electric charges for forming the electric field to the corresponding pad portions 11.

Optionally, the pad portion 11, the electrode 2 and the capacitor 3 are arranged in an array to facilitate forming a relatively uniform electric field.

In one example, the pad portions 11 have 12 rows, and are arranged in an array having 2 upper and lower rows and 4 middle 2 rows. Each land portion 11 is connected to one electrode 2, and the capacitors 3 are intensively distributed in both side regions of the connection portion 12 of the flexible circuit board 1.

In one example, as shown in fig. 2, the pad portions 11 have 20 rows of 6, and are arranged in an array having 2 rows of the upper and lower ends, and 4 rows of the middle. Each land portion 11 is connected to one electrode 2, and the capacitors 3 are intensively distributed in the middle area of the connection portion 12 of the flexible circuit board 1.

In one example, the pad portions 11 have 28 rows, and are arranged in an array having 2 upper and lower rows, and 4 middle 6 rows. The capacitors 3 are uniformly spaced and distributed on both side areas of the connection portion 12 of the flexible circuit board 1.

It should be noted that the array arrangement is not limited to the 3 arrangement manners provided in the foregoing embodiments, and the pad portions may be arranged in a polygonal array such as a rectangle, a circle, a triangle, etc., according to the size of the electrode patch and the specific structure of the flexible circuit board.

Alternatively, the electrode 2 may be a metal sheet or a conductive silicone sheet. The electrode 2 is used for conducting current and stabilizing current density, and finally outputting a stable electric field.

The inventors of the present application considered that when the electrode 2 and the capacitor 3 are connected by a flexible wire on the flexible circuit board 1, the position of the electrode 2 is easily shifted and even the electrode 2 itself is easily deformed. The strength of the flexible wire is not sufficient to support the electrode 2 and damage may occur. To this end, the present application provides one possible implementation for the electrode patch 120 as follows:

as shown in fig. 2, the electrode patch 120 of the present embodiment further includes a reinforcing sheet 6. The reinforcing sheet 6 is connected to the land portion 11 on the side away from the electrode 2.

In the present embodiment, the electrodes 2 and the reinforcing sheet 6 are symmetrically disposed with respect to the flexible circuit board 1, and the reinforcing sheet 6 may be respectively fixed to the pad portion 11 of the flexible circuit board 1 by soldering or tape adhesion. For supporting the electrode 2 against deformation or damage.

Alternatively, the material of the reinforcing sheet 6 may be polyethylene, polyvinyl chloride, polypropylene, polystyrene, or the like.

In one example, the reinforcing sheet 6 may be made of polyethylene, and a disc with a diameter of 20 mm and a thickness of 1 mm is used.

Optionally, as shown in fig. 2, the electrode patch 120 further includes a medical tape 4, and the medical tape 4 is connected to a side of the flexible circuit board 1 away from the electrode 2 and is used for at least partially applying to the surface of the target biological tissue. The medical adhesive tape 4 has adhesiveness on one surface, which is beneficial to applying structures such as the flexible circuit board 1 and the like on the surface of biological tissues. In addition, the medical adhesive tape 4 has good air permeability, which is beneficial to removing partial moisture and keeping the surface of the biological tissue dry.

The inventor of the present application considers that the medical tape 4 needs to be applied with a release paper adapted to its shape to maintain adhesiveness and to be isolated from the external environment. The release paper used in the electrode patch 120 in the prior art is a whole piece and completely attached to the medical adhesive tape 4, which is not conducive to an operator to quickly and effectively peel off the release paper adhered to the medical adhesive tape 4 when using the electrode patch 120. To this end, the present application provides one possible implementation for the electrode patch 120 as follows:

as shown in fig. 2, the electrode patch 120 of the embodiment of the present application further includes: a first release liner 8 and a second release liner 9.

The first release paper 8 and the second release paper 9 are respectively connected with one side of the flexible circuit board 1 far away from the medical adhesive tape 4.

The projection of one part of the first release paper 8 on the first plane is overlapped with one part of the projection of the medical adhesive tape 4 on the first plane, and the projection of one part of the second release paper 9 on the first plane is overlapped with the other part of the projection of the medical adhesive tape 4 on the first plane; the first plane is parallel to the plane of the medical tape 4.

The projection of the other part of the first release paper 8 on the second plane is at least partially overlapped with the projection of the other part of the second release paper 9 on the second plane, and the second plane and the first plane form an acute angle or a right angle.

In this embodiment, a part of the first release paper 8 and a part of the second release paper 9 are respectively attached to the medical tape 4, and the other part of the first release paper 8 and the other part of the second release paper 9 have overlapping regions. Its structure is similar to woundplast, can realize comparatively easy drawing from the first juncture of leaving type paper 8 and second from type paper 9 and tear whole from type paper part during consequently use, the convenient operation of being convenient for fast.

In one example, a projection of a portion of the first release paper 8 on the first plane coincides with one third of a projection of the medical tape 4 on the first plane, and a projection of a portion of the second release paper 9 on the first plane coincides with two thirds of a projection of the medical tape 4 on the first plane; the projection of the other part of the first release paper 8 on the second plane completely coincides with the projection of the other part of the second release paper 9 on the second plane, and the second plane and the first plane form an angle of 30 degrees.

In one example, the projection of a part of the first release paper 8 on the first plane coincides with one half of the projection of the medical adhesive tape 4 on the first plane, and the projection of a part of the second release paper 9 on the first plane coincides with one half of the projection of the medical adhesive tape 4 on the first plane; the projection of the other part of the first release paper 8 on the second plane completely coincides with the projection of the other part of the second release paper 9 on the second plane, and the second plane and the first plane form an angle of 60 degrees.

In one example, as shown in fig. 2, a projection of a portion of the first release paper 8 on the first plane coincides with two-thirds of a projection of the medical tape 4 on the first plane, and a projection of a portion of the second release paper 9 on the first plane coincides with one-third of the projection of the medical tape 4 on the first plane; the projection of the other part of the first release paper 8 on the second plane completely coincides with the projection of the other part of the second release paper 9 on the second plane, and the second plane and the first plane form an angle of 90 degrees.

The inventor of the present application considers that when the electrode patch 120 is applied to the surface of a biological tissue for a long time, the skin tissue of the living body is isolated from the outside, so that the moisture generated by the skin tissue cannot be evaporated into the air in time, and the moisture is easily accumulated in the electrode patch to affect the output effect of the electric field. Meanwhile, when the electrodes 2 and the capacitors 3 are disposed on the flexible circuit board 1, the shape characteristics of the electrodes themselves may cause unevenness on the surface of the flexible circuit board 1, thereby causing the electrode patch 120 to be difficult to completely adhere to the biological tissue. To this end, the present application provides one possible implementation for the electrode patch 120 as follows:

as shown in fig. 2, the electrode patch 120 further includes: and (5) foam cotton. The foam 5 is connected with one side of the flexible circuit board 1 close to the capacitor 3 and at least partially covers the flexible circuit board 1. The foam 5 is provided with an electrode 2 through hole and a capacitor 3 through hole, the electrode 2 through hole is embedded with the electrode 2, and the capacitor 3 through hole is embedded with the capacitor 3.

In this embodiment, the loose porous structure of the foam 5 can absorb moisture to keep the electrode patch 120 dry, and at the same time, accelerate the heat dissipation. In addition, the redundant space of the electrodes 2 and the capacitors 3 on the flexible circuit board 1 can be effectively filled, so that the surface of the flexible circuit board 1 becomes flat, and the electrode patch 120 can be completely attached to the biological tissue.

In one example, the foam 5 covers the entire area of the flexible circuit board 1.

In one example, as shown in fig. 2, the foam 5 covers a partial area of the flexible circuit board 1.

The inventor of the present application considers that, in the tumor electric field treatment process, the electrode patch 120 is applied to the surface of the biological tissue for a long time, and the comfort of the biological tissue is directly affected by the material in direct contact with the biological tissue. To this end, the present application provides one possible implementation for the electrode patch 120 as follows:

as shown in fig. 2, the electrode patch 120 further includes: conductive hydrogel sheet 7. Conductive hydrogel sheets 7 are connected to the side of the electrodes 2 remote from the flexible circuit board 1, each conductive hydrogel sheet 7 at least partially covering an electrode 2.

In this embodiment, the conductive hydrogel sheet 7 has high flexibility and high conductivity, and is in direct contact with the surface of the biological tissue, thereby improving the comfort of the living body. In addition, the conduction efficiency of the electric field can be increased.

Optionally, the conductive hydrogel sheet 7 has a thickness of 1 mm.

Based on the same inventive concept, the embodiment of the present application provides a cell-division inhibiting device 100, and the schematic structural diagram of the cell-division inhibiting device 100 is shown in fig. 4, which includes but is not limited to: any one of the electrode patches 120, the voltage generator 110 and the controller 130 as set forth in the above embodiments.

At least one pair of electrode patches 120, as set forth in the above-described embodiments, is adapted to be applied to the surface of a target biological tissue in a predetermined manner.

The voltage generator 110 is electrically connected to at least one pair of electrode patches 120 for outputting a voltage to each pair of electrode patches 120.

The controller 130 is electrically connected to the voltage generator 110 and the at least one pair of electrode patches 120 for controlling the voltage to adjust the strength and/or direction of the electric field of the at least one pair of electrode patches 120 such that each pair of electrode patches 120 forms a target electric field at least surrounding the target biological tissue.

In the present embodiment, since the cell-division suppressing apparatus 100 employs any one of the electrode patches 120 provided in the foregoing embodiments, the principle and technical effects thereof are please refer to the foregoing embodiments, and are not described herein again.

Alternatively, the voltage generator 110 is a pulsed voltage generator 110, which enables the electrode patches 120 to generate the required pulsed electric field.

Alternatively, the voltage generator 110 is an alternating voltage generator 110, which enables the electrode patches 120 to generate the required alternating electric field.

Optionally, each pair of electrode patches 120 is for attachment to opposite sides of a biological tissue surface; the connecting line of any pair of electrode patches 120 and the connecting line of the adjacent pair of electrode patches 120 form an angle alpha, and alpha is more than 0 and less than 90 degrees. So as to be beneficial to realizing a composite electric field and improving the effect of inhibiting cell division.

In one example, 3 pairs of electrode patches 120 are used to attach to a biological tissue surface, and the connection line of any pair of electrode patches 120 is 60 ° to the connection line of the adjacent pair of electrode patches 120.

In one example, 4 pairs of electrode patches 120 are used for attachment to a biological tissue surface, and the connection line of any pair of electrode patches 120 is 45 ° to the connection line of the adjacent pair of electrode patches 120.

Based on the same inventive concept, the present application provides a control method of the cell division inhibiting device 100 based on the foregoing embodiments, the method including:

the voltage generator 110 in the cell-division suppressing apparatus 100 is controlled to output voltages to the respective pairs of electrode patches 120 to form a target electric field that at least surrounds the target biological tissue to suppress division of at least a portion of the target cells or kill at least a portion of the target cells.

In this embodiment, the controller 130 may control the voltage generator 110 to output a voltage to the electrode patch 120, such that the electrode patch 120 can apply a voltage sequence to the target region, which may apply a potential to the target cell to induce an electric field in the target cell.

For the dividing cells, on one hand, in the metaphase of cell division, an electric field acts on the cells, electric field lines induced in the cells are gathered at the equatorial plate, and the organelles are subjected to the electric field force directed to the equatorial plate, so that the organelles are limited to move towards two poles, and the cell division can be inhibited to a certain extent.

On the other hand, as the degree of cell division is deepened (i.e. the equatorial plate is narrowed), the electric field lines at the equatorial plate become denser at the end of cell division, and the increased electric field can pull the organelle toward the equatorial plate to block the formation of the cell plate, thereby inhibiting cell division and even inducing cell rupture or apoptosis.

On the other hand, the cellular organelles are gathered at the equatorial plate, which causes an increase in the pressure near the equatorial plate, which may rupture the cell membrane, especially in the state of narrowing of the equatorial plate. And the electric field force applied to the organelles also affects the structures of the organelles, so that the disintegration or the rupture of the organelles can be induced, and the cell rupture or the apoptosis can be induced.

Therefore, the cell division suppression device 100 provided in the embodiment of the present application controls the voltage generator 110 to output a voltage to the electrode patch 120 through the controller 130, so that the electrode patch 120 can apply a voltage to a target region, can suppress cellular organelles in dividing cells from moving to two poles, and even can pull the cellular organelles to an equatorial plate to induce cell collapse or rupture, thereby achieving the effect of suppressing cell division or destroying cells, and the voltage hardly affects the cells that are not divided, thereby improving the ability of distinguishing tumor cells from healthy cells, not only improving the treatment effect, but also greatly reducing side effects.

Alternatively, the voltage generator 110 is controlled to output a target electric field to the target biological tissue through the at least one pair of electrode patches 120, the electric field strength of the target electric field being not less than 1 volt per centimeter and not more than 10 volts per centimeter. The voltage generator 110 provides such an electric field strength that an effective electric field is induced in the dividing cells that inhibits cell division.

Optionally, the control voltage generator 110 outputs a target electric field to the target biological tissue through the at least one pair of electrode patches 120, the target electric field having a frequency of not less than 50 khz and not more than 500 khz. At such frequencies, the voltage induces an electric field that inhibits cell division in dividing cells, and reduces or even eliminates the stimulatory effects on non-dividing cells. Thus being beneficial to improving the discrimination capability of the voltage on the tumor cells and the healthy cells, not only improving the treatment effect, but also greatly reducing the side effect.

Optionally, the control voltage generator 110 outputs a target electric field to the target biological tissue through the at least one pair of electrode patches 120, the target electric field having a frequency of not less than 100 khz and not more than 300 khz. This range may make the induced electric field more specific for certain tumor cells than a range of values of not less than 50 khz and not more than 500 khz.

Alternatively, controlling the voltage generator 110 in the cell-division suppressing device 100 to output voltages to the respective pairs of electrode patches 120 includes: at a first time interval, the voltage generator 110 in the cell-division suppressing device 100 is controlled to output a sequence of voltages to the target tissue through each pair of electrode patches 120 in sequence. The voltages received by each pair of electrode patches 120 are out of phase and are equal to each other to form a plurality of directionally divergent target electric fields within the target area.

Optionally, the rotation rate of the target electric field is the inverse of the frequency of the target electric field.

In this embodiment, the first time interval may be in the order of milliseconds or nanoseconds. The voltages received by each pair of electrode patches 120 are out of phase and are equal by controlling the time interval to form a plurality of directionally divergent target electric fields within the target area. After the tumor cell is induced to the electric field, the tumor cell is acted by the electric field, so that organelles in the cell are prevented from moving towards two poles in the metaphase of cell division, or the organelles are pulled towards an equatorial plate in the terminal stage of cell division, and the tumor cell is apoptotic.

In one example, the first time interval is 1 nanosecond, and the voltage generator 110 in the cell-division inhibiting device 100 is controlled to sequentially output a sequence of voltages to the target tissue through each pair of electrode patches 120. The voltages received by each pair of electrode patches 120 are out of phase and are equal to each other to form a plurality of directionally divergent target electric fields within the target area.

In one example, the first time interval is 0.2 milliseconds, and the voltage generator 110 in the cell-division inhibiting device 100 is controlled to output a sequence of voltages to the target tissue in turn through each pair of electrode patches 120. The voltages received by each pair of electrode patches 120 are out of phase and are equal to each other to form a plurality of directionally divergent target electric fields within the target area.

Alternatively, controlling the voltage generator 110 in the cell-division suppressing device 100 to output voltages to the respective pairs of electrode patches 120 includes: controlling the voltage generator 110 to alternately output a first voltage sequence and a second voltage sequence to each pair of electrode patches 120; the first voltage sequence and the second voltage sequence have different frequencies.

In this embodiment, the controller 130 controls the voltage generator 110 to alternately output two voltage sequences with different frequencies to the electrode patch 120, which is beneficial to meeting the requirements of target cells with different sizes on the electric field intensity and improving the treatment effect; on the other hand, the fatigue of the cells to the voltage sequence with single frequency can be reduced, and the effective treatment can be continuously realized.

Optionally, the first voltage sequence is a positive pulse sequence and the second voltage sequence is a negative pulse sequence.

Optionally, the first voltage sequence is a negative pulse sequence and the second voltage sequence is a positive pulse sequence.

Optionally, the first voltage sequence and the second voltage sequence are both positive pulse sequences.

Optionally, the first voltage sequence and the second voltage sequence are both negative pulse sequences.

In this embodiment, each of the electric pulses in the positive pulse sequence and the negative pulse sequence applies a relatively stable electric potential to the target cell, which is beneficial to subjecting the organelle to a relatively constant pulsed electric field force, drawing the organelle toward the equatorial plate, or hammering the cell membrane by the organelle.

The inventors of the present application considered that the first voltage sequence and the second pulse sequence output from the voltage generator 110 to the electrode patch 120 may be alternately output. For this reason, the present application provides the following three possible implementations for the alternating output form of the first voltage sequence and the second voltage sequence:

alternatively, the control voltage generator 110 alternately outputs the first voltage sequence and the second voltage sequence to the electrode patch 120. Including but not limited to steps S101 to S102:

s101: after determining that at least one first voltage of the first voltage sequence is output through the electrode patch 120, the electrode patch 120 is controlled to output at least one second voltage of the second voltage sequence.

S102: after determining that at least a portion of the first voltages in the first voltage sequence are output through the electrode patch 120, the electrode patch 120 is controlled to output at least another second voltage in the second voltage sequence.

Optionally, the control voltage generator 110 alternately outputs the first voltage sequence and the second voltage sequence to the electrode patch 120, including but not limited to steps S201 to S202:

s201: after determining that at least one first voltage of the first voltage sequence is output through the electrode patch 120, the electrode patch 120 is controlled to output at least one second voltage of the second voltage sequence.

S202: after determining that the first voltage sequence is stopped to be output through the electrode patch 120, the electrode patch 120 is controlled to output at least another second voltage in the second voltage sequence.

Alternatively, the control voltage generator 110 alternately outputs the first voltage sequence and the second voltage sequence to the electrode patch 120, including but not limited to steps S301 to S302:

s301: after determining that at least one first voltage of the first voltage sequence is output through the electrode patch 120, the electrode patch 120 is controlled to output at least one second voltage of the second voltage sequence.

S302: after determining that the output of the second voltage sequence through the electrode patch 120 is stopped, the electrode patch 120 is controlled to output at least another first voltage in the first voltage sequence.

Based on the same inventive concept, the embodiment of the present application provides a control device for a cell-division inhibiting device 100, which includes:

and a control module for controlling the voltage generator 110 in the cell-division inhibiting device 100 to output voltages to the electrode patches 120 to form a target electric field at least surrounding the target biological tissue so as to inhibit at least part of the target cells from dividing or kill at least part of the target cells.

In this embodiment, the control module may control the voltage generator 110 to output a sequence of voltages to the electrode patch 120, such that the electrode patch 120 is capable of applying a sequence of voltages to the tissue of the focal zone, which may apply potentials to the target cells to induce electric fields within the target cells.

Based on the same inventive concept, an embodiment of the present application provides an electronic device, including:

a processor;

a memory electrically connected to the processor;

at least one program stored in the memory and configured to be executed by the processor, the at least one program configured to: the control method of the cell division inhibiting device 100 provided in the embodiment of the present application is realized.

The embodiment of the application provides various optional implementation modes of the electronic equipment suitable for any one control method. And will not be described in detail herein.

Those skilled in the art will appreciate that the electronic devices provided by the embodiments of the present application may be specially designed and manufactured for the required purposes, or may comprise known devices in general-purpose computers. These devices have stored therein computer programs that are selectively activated or reconfigured. Such a computer program may be stored in a device (e.g., computer) readable medium or in any type of medium suitable for storing electronic instructions and respectively coupled to a bus.

Based on the same inventive concept, the present application provides a computer-readable storage medium, on which a computer program is stored, which, when executed by an electronic device/processor, implements the control method of any one of the cell-division inhibiting devices 100 provided by the present application.

By applying the embodiment of the application, at least the following beneficial effects can be realized:

1. in the electrode patch provided by the application, the capacitor is directly and electrically connected with the electrode, so that the dielectric loss of a dielectric material can be avoided, and the utilization rate of energy is improved. The heat dispersion of electric capacity is good, avoids the heat to gather in the electrode paster one side that is close to the body surface, has improved the comfort level on biological tissue surface. In addition, the efficiency of the electrode for outputting an electric field can be improved, and the division of tumor cells can be effectively inhibited.

2. In addition, the electrodes and the reinforcing sheets are symmetrically arranged relative to the flexible circuit board, and the reinforcing sheets can be fixed on the pad part of the flexible circuit board in a welding or adhesive tape adhesion mode respectively. For supporting the electrode to prevent it from being deformed or damaged.

3. Furthermore, one part of the first release paper and one part of the second release paper are respectively attached to the medical adhesive tape, and the other part of the first release paper and the other part of the second release paper have overlapped areas. Its structure is similar to woundplast, so that when in use, the first juncture of the release paper and the second release paper is pulled to tear off the whole release paper part, thereby facilitating the quick and convenient operation.

4. In addition, the loose and porous structure of the foam can absorb moisture to keep the electrode patch dry and accelerate the heat dissipation. In addition, the electrode 2 and the redundant space of electricity on the flexible circuit board can be effectively filled, so that the surface of the flexible circuit board 1 becomes flat, and the electrode patch is completely attached to the biological tissue.

5. The conductive hydrogel sheet has high flexibility and high conductivity, and is in direct contact with the surface of biological tissue, so that the comfort level of organisms is improved. In addition, the conduction efficiency of the electric field can be increased.

Those of skill in the art will appreciate that the various operations, methods, steps in the processes, acts, or solutions discussed in this application can be interchanged, modified, combined, or eliminated. Further, other steps, measures, or schemes in various operations, methods, or flows that have been discussed in this application can be alternated, altered, rearranged, broken down, combined, or deleted. Further, steps, measures, schemes in the prior art having various operations, methods, procedures disclosed in the present application may also be alternated, modified, rearranged, decomposed, combined, or deleted.

In the description of the present application, it is to be understood that the terms "center", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", and the like indicate orientations or positional relationships based on those shown in the drawings, and are only for convenience in describing the present application and simplifying the description, but do not indicate or imply that the referred device or element must have a particular orientation, be constructed in a particular orientation, and be operated, and thus should not be construed as limiting the present application.

The terms "first", "second" and "first" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defined as "first" or "second" may explicitly or implicitly include one or more of that feature. In the description of the present application, "a plurality" means two or more unless otherwise specified.

In the description of the present application, it is to be noted that, unless otherwise explicitly specified or limited, the terms "mounted," "connected," and "connected" are to be construed broadly, e.g., as meaning either a fixed connection, a removable connection, or an integral connection; they may be connected directly or indirectly through intervening media, or they may be interconnected between two elements. The specific meaning of the above terms in the present application can be understood in a specific case by those of ordinary skill in the art.

In the description herein, particular features, structures, materials, or characteristics may be combined in any suitable manner in any one or more embodiments or examples.

It should be understood that, although the steps in the flowcharts of the figures are shown in order as indicated by the arrows, the steps are not necessarily performed in order as indicated by the arrows. The steps are not performed in the exact order shown and may be performed in other orders unless explicitly stated herein. Moreover, at least a portion of the steps in the flow chart of the figure may include multiple sub-steps or multiple stages, which are not necessarily performed at the same time, but may be performed at different times, which are not necessarily performed in sequence, but may be performed alternately or alternately with other steps or at least a portion of the sub-steps or stages of other steps.

The foregoing is only a partial embodiment of the present application, and it should be noted that, for those skilled in the art, various modifications and decorations can be made without departing from the principle of the present application, and these modifications and decorations should also be regarded as the protection scope of the present application.

Claims

1. An electrode patch, comprising: the flexible circuit board, and a capacitor and an electrode which are respectively connected with the flexible circuit board;

the first pole of the capacitor is electrically connected with a power supply through the flexible circuit board;

the second pole of the capacitor is electrically connected with the electrode through the flexible circuit board;

the electrodes are used to output a target electric field to a target tissue.

2. The electrode patch as claimed in claim 1, wherein the capacitors and the electrodes are electrically connected in a one-to-one correspondence;

and/or the capacitor and the electrode are positioned on the same side of the flexible circuit board.

3. The electrode patch according to claim 1 or 2, wherein the flexible circuit board comprises at least one pad portion, and a connecting portion connecting adjacent two of the pad portions;

the electrode is electrically connected with one side of the pad part;

the capacitor is electrically connected with one side of the connecting part.

4. The electrode patch as claimed in claim 3, further comprising: a reinforcing sheet;

the reinforcing sheet is connected to one side of the pad portion away from the electrode.

5. The electrode patch as claimed in claim 1, further comprising: medical adhesive tape;

the medical adhesive tape is connected with one side of the flexible circuit board far away from the electrode and is used for being at least partially attached to the surface of target biological tissue.

6. The electrode patch as claimed in claim 5, further comprising: a first release paper and a second release paper;

the first release paper and the second release paper are respectively connected with one side of the flexible circuit board, which is far away from the medical adhesive tape;

the projection of one part of the first release paper on the first plane is overlapped with one part of the projection of the medical adhesive tape on the first plane, and the projection of one part of the second release paper on the first plane is overlapped with the other part of the projection of the medical adhesive tape on the first plane; the first plane is parallel to the plane of the medical adhesive tape;

7. The electrode patch as claimed in claim 6, further comprising: soaking cotton;

the foam is connected with one side of the flexible circuit board close to the capacitor, and at least partially covers the flexible circuit board;

8. The electrode patch as claimed in claim 7, further comprising: a conductive hydrogel sheet;

the conductive hydrogel sheets are connected with one side of the electrode, which is far away from the flexible circuit board, and each conductive hydrogel sheet at least partially covers the electrode.

9. A cell-division inhibiting device comprising:

at least one pair of electrode patches according to any one of claims 1-8 for application to a surface of a target biological tissue according to a predetermined pattern;

a voltage generator electrically connected to the at least one pair of electrode patches for outputting a voltage to each pair of electrode patches;

a controller electrically connected to the voltage generator, the at least one pair of electrode patches, for controlling the voltage to adjust the strength and/or direction of the electric field of the at least one pair of electrode patches such that each pair of electrode patches forms a target electric field at least surrounding a target biological tissue.

10. The device according to claim 9, wherein the voltage generator is a pulse voltage generator or an alternating voltage generator.

11. The cell-division suppressing device of claim 9, wherein each pair of the electrode patches is adapted to be attached to opposite sides of the surface of the biological tissue; an angle alpha is formed between the connecting line of any pair of the electrode patches and the connecting line of the adjacent pair of the electrode patches, and alpha is more than 0 and less than 90 degrees.

12. A method for controlling a cell-division suppressing apparatus according to any one of claims 9 to 11, comprising:

controlling a voltage generator in the cell-division inhibiting device to output a voltage to each pair of the electrode patches to form the target electric field at least surrounding the target biological tissue to inhibit at least a portion of the target cells from dividing or kill at least a portion of the target cells.