CN113491584B - Liquid metal flexible patch for CT positioning and preparation method thereof - Google Patents
Liquid metal flexible patch for CT positioning and preparation method thereof Download PDFInfo
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- CN113491584B CN113491584B CN202010199601.5A CN202010199601A CN113491584B CN 113491584 B CN113491584 B CN 113491584B CN 202010199601 A CN202010199601 A CN 202010199601A CN 113491584 B CN113491584 B CN 113491584B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
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Abstract
The invention discloses a liquid metal flexible patch for CT positioning and a preparation method thereof, and relates to the field of flexible medical equipment. The preparation method comprises the following steps: mixing high-density solid metal particles, liquid metal and a flexible and stretchable high polymer material to prepare a high-density liquid metal compound; wherein the density of the high-density solid metal is greater than the density of the liquid metal; and coating the high-density liquid metal compound on a bearing substrate, and curing the high-density liquid metal compound to obtain the liquid metal flexible patch. The liquid metal flexible patch has high-intensity imaging capability in CT scanning, helps doctors obtain more image information, and accurately positions the focus position. The flexible patch has the advantages of simple and easy preparation method, low cost, good stretchability and compliance, and can be widely used for radiation imaging detection and treatment.
Description
Technical Field
The invention belongs to the field of flexible medical equipment, and particularly relates to a liquid metal flexible patch for CT positioning and a preparation method thereof.
Background
In recent years, flexible medical electronic devices, such as an attached body temperature sensor, have been widely used. In addition, CT devices are also widely used during percutaneous aspiration procedures. After the CT device obtains the internal tissue image of the human body, the doctor needs to determine the puncture position on the body surface of the patient according to the CT image. During actual clinical treatment, physicians often attach specially shaped metal patches to the skin surface of patients. The metal patch has a remarkable imaging effect in a CT image, and a doctor can be helped to better determine the puncture position and the puncture angle by analyzing the relative position relation between the metal patch and a focus in the CT image. However, the metal patch for CT positioning is made of metal foils such as copper and iron, has high mechanical strength, is not easy to stretch or bend, and thus cannot perfectly fit soft tissues such as human skin, and is easy to cause discomfort of a patient or displacement of the patch.
Disclosure of Invention
In view of the above, an object of the present invention is to provide a liquid metal flexible patch for CT positioning and a method for manufacturing the same, so as to solve the problems of high mechanical strength and difficult bending of a metal patch for CT positioning in the prior art.
In some illustrative embodiments, the method for preparing a liquid metal flexible patch for CT localization comprises: mixing high-density solid metal particles, liquid metal and a flexible and stretchable high polymer material to prepare a high-density liquid metal compound; wherein the density of the high-density solid metal is greater than the density of the liquid metal; and coating the high-density liquid metal compound on a bearing substrate, and curing the high-density liquid metal compound to obtain the liquid metal flexible patch.
In some optional embodiments, the preparing the high-density liquid metal composite by mixing the high-density solid metal particles, the liquid metal and the flexible stretchable high polymer material specifically includes: fully mixing the high-density solid metal particles with molten liquid metal to obtain high-density liquid metal slurry; and fully mixing the high-density liquid metal slurry with a flexible and stretchable high polymer material to obtain the high-density liquid metal composite.
In some optional embodiments, in the process of applying the high-density liquid metal composite to a carrier substrate and obtaining a liquid metal flexible patch after the high-density liquid metal composite is cured, the process includes: and coating the high-density liquid metal compound on a bearing substrate by using a patterning technology to obtain the liquid metal flexible patch with the target pattern.
In some optional embodiments, in the process of applying the high-density liquid metal composite to a carrier substrate, and after the high-density liquid metal composite is cured, obtaining a liquid metal flexible patch, the process includes: and separating the liquid metal flexible patch from the bearing substrate.
In some optional embodiments, the high-density solid metal particles are selected from one or more of gold, silver, copper, and lead.
In some alternative embodiments, the high-density solid-state metal particles have a particle size of no more than 100 microns.
In some optional embodiments, the flexible and stretchable polymer material is selected from one or more of silicone, epoxy resin, polydimethylsiloxane and polyurethane.
In some alternative embodiments, the thickness of the cured high density liquid metal composite ranges from 0.5 to 2 millimeters.
Another object of the present invention is to provide a flexible liquid metal patch for CT positioning to solve the technical problems in the prior art.
In some illustrative embodiments, the liquid metal flexible patch for CT positioning is obtained by the above-mentioned method for preparing a liquid metal flexible patch for CT positioning.
In some optional embodiments, the flexible liquid metal patch for CT positioning is characterized in that the flexible liquid metal patch is attached to the surface layer of the patient's skin by skin adhesive glue.
Compared with the prior art, the invention has the following technical advantages:
the liquid metal flexible patch has high-intensity imaging capability in CT scanning, helps doctors obtain more image information, and accurately positions the focus position. The flexible patch has the advantages of simple and easy preparation method, low cost, good stretchability and compliance, and can be widely used for radiation imaging detection and treatment.
Drawings
FIG. 1 is a flow chart of a method for manufacturing a liquid metal flexible patch for CT positioning according to an embodiment of the present invention;
FIG. 2 is a schematic illustration of the preparation of a high density liquid metal composite in an embodiment of the invention;
FIG. 3 is a schematic diagram of the fabrication of a liquid metal flexible patch in an embodiment of the invention;
FIG. 4 is a schematic diagram of the use of a liquid metal flexible patch in an embodiment of the present invention;
fig. 5 is a schematic drawing showing the stretching effect of the high-density liquid metal composite and the silica gel composite doped with only the high-density solid metal particles in the embodiment of the present invention.
Detailed Description
The following description and the drawings sufficiently illustrate specific embodiments of the invention to enable those skilled in the art to practice them. Other embodiments may incorporate structural, logical, electrical, process, and other changes. The examples merely typify possible variations. Individual components and functions are optional unless explicitly required, and the sequence of operations may vary. Portions and features of some embodiments may be included in or substituted for those of others. The scope of embodiments of the invention encompasses the full ambit of the claims, as well as all available equivalents of the claims. Embodiments of the invention may be referred to herein, individually or collectively, by the term "invention" merely for convenience and without intending to voluntarily limit the scope of this application to any single invention or inventive concept if more than one is in fact disclosed.
It should be noted that the technical features in the embodiments of the present invention may be combined with each other without conflict.
The embodiment of the invention discloses a preparation method of a liquid metal flexible patch for CT positioning, and particularly, as shown in figure 1, the preparation method comprises the following steps:
s11, preparing a high-density liquid metal compound by mixing high-density solid metal particles, liquid metal and a flexible and stretchable high polymer material;
wherein the density of the high-density solid metal is greater than the density of the liquid metal; in addition, "high density" in the high-density liquid metal composite is not a limitation on a specific value of the density thereof, but includes high-density solid metal particles.
And S12, coating the high-density liquid metal compound on a bearing substrate, and curing the high-density liquid metal compound to obtain the liquid metal flexible patch.
The curing may be by thermal curing, natural curing, light curing, sintering, or the like.
The liquid metal flexible patch has high-intensity imaging capability in CT scanning, helps doctors obtain more image information, and accurately positions the focus position. The flexible patch has the advantages of simple and easy preparation method, low cost, good stretchability and compliance, and can be widely used for radiation imaging detection and treatment.
The liquid metal in the embodiment of the invention can be low-melting-point metal in a liquid state at room temperature, such as gallium-based alloy, specifically gallium-indium eutectic alloy, gallium-tin eutectic alloy, gallium-indium-tin-zinc eutectic alloy and the like, and the low-melting-point metal has an extremely low melting point, so that the manufacturing of the liquid metal flexible patch can be completed at room temperature.
Specifically, the high-density solid metal particles in the embodiment of the present invention refer to metal particles which have a higher density than that of the liquid metal used and are in a solid state at normal temperature, for example, metals such as lead, gold, silver, and copper. The particle size range of the metal particles is not more than 200 microns, so that the high-density solid metal particles can be fully mixed in the high-density solid metal compound, the phase separation is not easy, and the good radiation imaging performance is achieved. Further, the particle size range of the metal particles is selected to be not more than 100 μm in particle size, the high-density solid metal particles have excellent radiation imaging ability, and the particle size range is selected to be not more than 100 μm in particle size, which facilitates the mixing of the solid metal particles in the liquid metal and the polymer material, thereby achieving good radiation imaging performance of the high-density liquid metal composite.
Specifically, the flexible and stretchable polymer material in the embodiment of the present invention may be one or more of silicone, epoxy resin, polydimethylsiloxane, and polyurethane. Can tensile macromolecular material help carrying out the cladding encapsulation to the metal thick liquids of solid-state metal and liquid metal through this flexibility, realize the shaping of the flexible paster after the metal thick liquids printing to and prevent overflowing of material, and reduce with the air contact degree.
In the embodiment of the invention, the high-density solid metal particles, the liquid metal and the high polymer material are fully mixed, so that the bending performance and the stretching performance of the liquid metal flexible patch can be realized based on the high polymer material, and the liquid metal coated in the high polymer material can deform along with the stretching and bending of the high polymer material due to the characteristics of fluid of the liquid metal, so that the flexible stretching of high-density metal slurry is met, the flexible stretching performance which is lacked by the traditional metal patch is met, the liquid metal can play the flexible stretching performance, and the connection of the high-density solid metal particles can be realized, so that the good radiation imaging performance of the liquid metal flexible patch is realized.
Preferably, in step S11 of the embodiment of the present invention, the preparing of the high-density liquid metal composite by mixing the high-density solid metal particles, the liquid metal, and the flexible stretchable polymer material specifically includes:
fully mixing the high-density solid metal particles with molten liquid metal to obtain high-density liquid metal slurry; wherein, the mass ratio of the high-density solid metal particles to the liquid metal can be selected from 5: 1-20: 1, such as 6:1, 7:1, 8:1, 9:1, 10:1, 11:1, 12:1, 13:1, 14:1, 15:1, 16:1, 17:1, 18:1 or 19: 1; the high-density liquid metal slurry prepared by the proportion has the advantages that the high-density solid metal particles and the liquid metal are easy to mix fully, and are not easy to agglomerate and phase split.
And fully mixing the high-density liquid metal slurry with a flexible and stretchable high polymer material to obtain the high-density liquid metal composite. Wherein, the mass ratio of the high-density liquid metal slurry to the high polymer material can be selected from 10: 1-20: 1, such as 11:1, 12:1, 13:1, 14:1, 15:1, 16:1, 17:1, 18:1 or 19: 1. The high-density liquid metal compound prepared by the proportion has more uniform high-density solid metal particles and liquid metal in the high-density liquid metal slurry, and can improve the coating quality.
In a preferred embodiment, the high-density metal particles and the liquid metal are fully mixed, and then the mixed metal slurry and the high polymer material are fully mixed, so that compared with a high-density liquid metal compound formed by directly mixing the three materials at one time, the high-density liquid metal compound contributes to the connection of the high-density solid metal particles and the liquid metal, and reduces the difficulty of direct mixing of the three materials. The mixing in this application can be through modes such as manual stirring, mechanical stirring, ball-milling, rolling.
Preferably, step S12 in this embodiment of the present invention is to coat the high-density liquid metal composite on a carrier substrate, and after the high-density liquid metal composite is solidified, obtain a liquid metal flexible patch, including:
and coating the high-density liquid metal compound on a bearing substrate by using a patterning technology to obtain the liquid metal flexible patch with the target pattern.
The patterning technology is not limited to the pattern printing mode of setting a mask, printing, screen printing, pad printing and the like, or the selective adhesion to the high-density liquid metal composite is realized by firstly setting a patterned modified coating on the bearing substrate.
The carrying substrate in the embodiment of the present invention may be a flexible stretchable substrate, a flexible non-stretchable substrate, or a rigid substrate; the bearing substrate can be used as an intermediate carrier, and after the high-density liquid metal compound is cured, the cured high-density liquid metal compound is separated from the bearing substrate to obtain a liquid metal flexible patch for storage or use. When in use, the liquid metal flexible patch is directly attached to the skin of a patient.
In other embodiments, the carrier substrate and the cured high-density liquid metal composite together form a liquid metal flexible patch, and the carrier substrate is used as a component of the liquid metal flexible patch, and may be a flexible stretchable substrate, a flexible non-stretchable substrate, or the like, such as a tearable paper, a fine mesh fabric, or the like. When the liquid metal flexible patch is used, one side covered with the liquid metal compound can be directly attached to the skin surface layer of a patient for use, the bearing base material does not need to be removed, and the liquid metal flexible patch is also attached to the skin of the patient to strengthen the position fixation of the liquid metal flexible patch. Wherein, can form the adhesive linkage through coating at patient's skin top layer, then attach liquid metal flexible patch, the adhesive linkage realizes the adhesion of the high density liquid metal complex and the bearing substrate after the solidification.
In other embodiments, when the liquid metal flexible patch is prepared, an adhesive layer can be attached to one surface of the bearing substrate, which is covered with the liquid metal flexible patch, and the adhesive layer is used for adhering the liquid metal flexible patch on the surface layer of the skin of a patient, and can be directly used for adhering without coating other adhesive materials on the skin of the patient. Preferably, the surface of the bonding layer is also provided with an easy-to-tear layer, and the easy-to-tear layer is removed before being attached.
The thickness range of the solidified high-density liquid metal compound in the embodiment of the invention is 0.5-2 mm, and a plurality of layers of high-density solid metal particles and liquid metal can be connected in the process, so that the influence of the liquid metal and high polymer materials on radiation imaging can be reduced through stacking of the layers, the radiation imaging quality of the liquid metal flexible patch is ensured, and on the other hand, the mechanical strength of the liquid metal flexible patch with the thickness is lower, and the flexible and stretchable performance of the liquid metal flexible patch can be ensured.
The embodiment of the invention also discloses a liquid metal flexible patch for CT positioning, which can be obtained by any preparation method.
The embodiment of the invention particularly discloses a liquid metal flexible patch for CT positioning, which is a solidified high-density liquid metal compound separated from a bearing substrate. The flexible liquid metal patch can be used as medical adhesive, and when the flexible liquid metal patch is used, the medical adhesive is firstly coated on the surface layer of the skin of a patient, and then the flexible liquid metal patch is adhered to the coating position of the medical adhesive. The medical adhesive is not easy to damage skin, and besides the medical adhesive, common glue, adhesive films, non-setting adhesives and the like can be selected and used, so that the adhesion of the liquid metal flexible patch in the application can be met.
In other embodiments, a CT-positioned liquid metal flexible patch is also disclosed, comprising: a support substrate; and a cured high density liquid metal composite attached to the carrier substrate. Wherein, the bearing substrate can be selected from flexible stretchable substrate and flexible non-stretchable substrate. When the liquid metal flexible patch is used, the liquid metal flexible patch can be matched with the glue, the adhesive film and the non-setting adhesive for use, and the bearing substrate can be directly adhered to the skin surface of a patient without being removed, so that the position fixation of the high-density liquid metal compound is enhanced.
In other embodiments, a CT-positioned liquid metal flexible patch is also disclosed, comprising: a support substrate; and the solidified high-density liquid metal composite is attached to the bearing substrate, the adhesive layer covers the high-density liquid metal composite, and the easy-to-tear layer is positioned on the adhesive layer. The bonding layer covers one side of the bearing substrate, which is covered with the high-density liquid metal compound, and simultaneously covers the high-density liquid metal compound.
In some embodiments, the skin of the patient can also be protected by first forming an isolation layer on the surface of the skin of the patient without injuring the skin tissue, and then adhering the liquid metal flexible patch on the isolation layer, thereby preventing the adhesive layer from directly contacting with the surface layer of the skin of the patient. For example, when the isolation layer is a double-layer structure, the bottom layer (the layer contacting the skin) is a film layer with good biocompatibility, and the top layer (the layer contacting the liquid metal) is a film layer capable of adhering the liquid metal and the packaging layer. The isolation layer can be made of one or more of PU (polyurethane) transdermal adhesive, double-sided adhesive, hand film (or hand wax), VAE (vinyl acetate) emulsion, double-component vulcanized silica gel (the component A is vulcanized silica gel, the component B is platinum catalyst) and the like. Preferably, the isolation layer is of a double-layer structure, the bottom layer is vulcanized silica gel, and the top layer is a hand membrane (or hand wax).
Optionally, the thickness of the isolation layer 5 is 50 to 70 microns. The isolation layer can be formed by various modes such as spraying, smearing, sticking and the like, the formed isolation layer can be dried quickly in a short time (within 5-20 min for example), and the isolation layer can be cleaned easily by using the hand sanitizer and the soap.
In order to facilitate those skilled in the art to quickly understand the core ideas and effects of the present application, the present invention further provides a preferred embodiment:
referring to fig. 2, the method for manufacturing and using the liquid metal flexible patch for CT positioning according to the present invention employs a high density liquid metal composite (1), a mask (2), a skin adhesive (3), and the like. The preparation method of the high-density liquid metal compound (1) comprises the following steps: firstly, weighing a certain mass of high-density solid metal particles (1-a), such as lead particles (the diameter is 1-3 microns), putting the high-density solid metal particles into a beaker, and then weighing a certain mass of liquid metal gallium-indium alloy (1-b) in proportion and putting the liquid metal gallium-indium alloy into the beaker. And stirring by using a glass rod or a grinding rod to fully mix the two, and finally obtaining the uniform high-density liquid metal slurry (1-c). The doping mass ratio range of the high-density solid metal particles (1-a) and the liquid metal gallium-indium alloy (1-b) is 9: 1.
then weighing a certain mass of high-density liquid metal slurry (1-c) and a flexible stretchable high polymer material (1-d) to be mixed and stirred together to prepare the high-density liquid metal composite (1). The mass ratio range of the high-density liquid metal slurry (1-c) to the flexible and stretchable high polymer material (1-d) is 14.5: 1.
referring to fig. 3, when in use, firstly, the mask plate (2) is placed on a smooth silicon wafer (glass sheet) (2-a), then the high-density liquid metal compound (1) is uniformly coated on the upper surface of the mask plate (2), and the high-density liquid metal compound (1) is filled in the hollow part of the mask plate (2) and is adhered on the silicon wafer (2-a). And then, removing the redundant high-density liquid metal compound (1) on the upper surface of the mask plate (2) by using a scraper (2-b). After the mask plate (2) is removed, the high-density liquid metal compound (1) forms a specific pattern on the silicon wafer (2-a), and the specific pattern is heated, solidified and formed into a film, so that the liquid metal flexible patch (2-c) is obtained. Finally, referring to fig. 4, the skin adhesive (3) is coated on the lower surface of the liquid metal flexible patch (2-c) and is applied on the surface of the skin (3-a) of the patient. In CT images, the liquid metal flexible patch (2-c) exhibits a high intensity imaging effect to help a physician determine the relative position of the lesion (3-b) and the puncture site.
Referring to fig. 5, compared with the silicone composite (4-b) formed by only mixing the solid metal particles (4-a), the liquid metal slurry (1-c) in the liquid metal flexible patch (2-c) can be stretched along with the liquid metal flexible patch (2-c) in the stretching process, so that the surface area is increased, and the radiation imaging effect of the metal particles is ensured; in contrast, the solid metal particles (4-a) cannot be stretched and increase in distance from each other, resulting in a decrease in the radiographic effect.
Those of skill would further appreciate that the various illustrative logical blocks, modules, circuits, and algorithm steps described in connection with the embodiments disclosed herein may be implemented as electronic hardware, computer software, or combinations of both. To clearly illustrate this interchangeability of hardware and software, various illustrative components, blocks, modules, circuits, and steps have been described above generally in terms of their functionality. Whether such functionality is implemented as hardware or software depends upon the particular application and design constraints imposed on the overall system. Skilled artisans may implement the described functionality in varying ways for each particular application, but such implementation decisions should not be interpreted as causing a departure from the scope of the present disclosure.
Claims (9)
1. A preparation method of a liquid metal flexible patch for CT positioning is characterized by comprising the following steps:
mixing solid metal particles, liquid metal and a flexible and stretchable high polymer material to prepare a liquid metal compound; wherein the density of the solid metal is greater than the density of the liquid metal;
coating the liquid metal compound on a bearing substrate, and curing the liquid metal compound to obtain a liquid metal flexible patch;
wherein, the solid metal particles are selected from one or more of gold, silver, copper and lead; the liquid metal is gallium-based alloy in a liquid state at room temperature.
2. The method for preparing a flexible liquid metal patch for CT positioning according to claim 1, wherein the preparing of the liquid metal composite by mixing the solid metal particles, the liquid metal and the flexible stretchable polymer material specifically comprises:
fully mixing the solid metal particles with molten liquid metal to obtain liquid metal slurry;
and fully mixing the liquid metal slurry with a flexible and stretchable high polymer material to obtain the liquid metal composite.
3. The method for preparing a flexible liquid metal patch for CT mapping according to claim 1, wherein the step of coating the liquid metal composite on a carrier substrate to obtain the flexible liquid metal patch after the liquid metal composite is solidified comprises:
and coating the liquid metal compound on a bearing substrate by using a patterning technology to obtain a liquid metal flexible patch with a target pattern.
4. The method for preparing a flexible liquid metal patch for CT mapping according to claim 1, wherein the step of coating the liquid metal composite on a carrier substrate to obtain the flexible liquid metal patch after the liquid metal composite is solidified comprises:
and separating the liquid metal flexible patch from the bearing substrate.
5. A method for preparing a liquid metal flexible patch for CT positioning as claimed in any one of claims 1-4, wherein the solid metal particles have a particle size not exceeding 100 microns.
6. A method for preparing a flexible liquid metal patch for CT positioning according to any one of claims 1-4, wherein the flexible and stretchable polymer material is selected from one or more of silicone, epoxy resin, polydimethylsiloxane and polyurethane.
7. A method for preparing a liquid metal flexible patch for CT positioning as claimed in any one of claims 1-4, wherein the thickness of the solidified liquid metal composite is in the range of 0.5-2 mm.
8. A flexible liquid metal patch for CT positioning, which is obtained by the method for preparing the flexible liquid metal patch for CT positioning as claimed in any one of claims 1-7.
9. The flexible patch of liquid metal for CT localization according to claim 8, wherein the flexible patch of liquid metal is attached to the surface layer of the patient's skin by a skin adhesive glue.
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