CN113495086B - POCT blood cell analyzer and kit - Google Patents
POCT blood cell analyzer and kit Download PDFInfo
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- CN113495086B CN113495086B CN202010260842.6A CN202010260842A CN113495086B CN 113495086 B CN113495086 B CN 113495086B CN 202010260842 A CN202010260842 A CN 202010260842A CN 113495086 B CN113495086 B CN 113495086B
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- 210000000601 blood cell Anatomy 0.000 title claims abstract description 65
- 238000012123 point-of-care testing Methods 0.000 title claims abstract description 57
- 238000001514 detection method Methods 0.000 claims abstract description 209
- 210000004027 cell Anatomy 0.000 claims abstract description 89
- 239000003153 chemical reaction reagent Substances 0.000 claims abstract description 72
- 230000003287 optical effect Effects 0.000 claims abstract description 44
- 230000005540 biological transmission Effects 0.000 claims description 18
- 238000007789 sealing Methods 0.000 claims description 15
- 239000002699 waste material Substances 0.000 claims description 9
- 238000003780 insertion Methods 0.000 claims description 6
- 230000037431 insertion Effects 0.000 claims description 6
- 238000004891 communication Methods 0.000 claims description 4
- 229920003023 plastic Polymers 0.000 claims description 4
- 239000011521 glass Substances 0.000 claims description 2
- 210000001503 joint Anatomy 0.000 claims description 2
- 239000004033 plastic Substances 0.000 claims description 2
- 230000005611 electricity Effects 0.000 claims 1
- 210000004369 blood Anatomy 0.000 abstract description 16
- 239000008280 blood Substances 0.000 abstract description 16
- 238000002360 preparation method Methods 0.000 abstract description 5
- 238000010790 dilution Methods 0.000 abstract description 3
- 239000012895 dilution Substances 0.000 abstract description 3
- 238000002203 pretreatment Methods 0.000 abstract description 2
- 230000033001 locomotion Effects 0.000 description 30
- 239000007788 liquid Substances 0.000 description 27
- 238000004140 cleaning Methods 0.000 description 11
- 238000002156 mixing Methods 0.000 description 10
- 238000000034 method Methods 0.000 description 5
- 238000003825 pressing Methods 0.000 description 5
- 239000000243 solution Substances 0.000 description 5
- 238000010586 diagram Methods 0.000 description 4
- 238000010438 heat treatment Methods 0.000 description 4
- 206010023435 Kidney small Diseases 0.000 description 3
- 230000000712 assembly Effects 0.000 description 3
- 238000000429 assembly Methods 0.000 description 3
- 239000003085 diluting agent Substances 0.000 description 3
- 238000010295 mobile communication Methods 0.000 description 3
- 238000000926 separation method Methods 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 206010018910 Haemolysis Diseases 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000004159 blood analysis Methods 0.000 description 1
- 230000005587 bubbling Effects 0.000 description 1
- 210000005056 cell body Anatomy 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000008094 contradictory effect Effects 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 230000008588 hemolysis Effects 0.000 description 1
- 239000003219 hemolytic agent Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/02—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
- G01N21/27—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands using photo-electric detection ; circuits for computing concentration
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/47—Scattering, i.e. diffuse reflection
- G01N21/49—Scattering, i.e. diffuse reflection within a body or fluid
- G01N21/51—Scattering, i.e. diffuse reflection within a body or fluid inside a container, e.g. in an ampoule
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/59—Transmissivity
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
- G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
- G01N21/78—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a change of colour
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
- G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
- G01N21/82—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a precipitate or turbidity
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- Physics & Mathematics (AREA)
- Chemical & Material Sciences (AREA)
- Pathology (AREA)
- Immunology (AREA)
- General Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Plasma & Fusion (AREA)
- Electrochemistry (AREA)
- Mathematical Physics (AREA)
- Theoretical Computer Science (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
Abstract
The invention provides a POCT (point-of-CARE TESTING) blood cell analyzer and a kit, wherein the kit comprises a kit body, a plurality of impedance detection cells, a plurality of optical detection cells and a plurality of reagent cells, and the plurality of impedance detection cells are connected with the kit body and are used for carrying out impedance detection in a matching way; the optical detection tanks are connected with the box body and are used for carrying out photoelectric detection in a matched mode; the plurality of reagent pools are connected with the box body and are used for accommodating a plurality of reagents. According to the kit, a plurality of impedance detection pools, a plurality of optical detection pools and a plurality of reagent pools are arranged, so that impedance detection and/or colorimetric detection and/or turbidimetric detection of a blood sample can be supported, the number of detection items is large, the expandability of the detection items is good, dilution of the sample to be detected and pre-treatment of adding a reagent can be carried out through the preparation of the reagent pre-installed in the reagent pools, and the POCT detection efficiency is optimized.
Description
Technical Field
The invention relates to the technical field of blood sample analysis, in particular to a POCT blood cell analyzer and a kit.
Background
The blood cell analyzer is also called a blood cell analyzer, a hemocytometer, a blood cell counter and the like, and is one of the very wide instruments for clinical examination in hospitals.
A significant portion of the components in conventional blood cell analyzers are part of the cleaning system because the trace of the last blood sample must be cleaned before the next blood sample test. The whole cleaning system is complex in structure and multiple in parts, and a large amount of reagents are required to be used in the cleaning process, so that the cleaning system takes a long time.
Compared with the traditional blood cell analyzer, the POCT blood cell analyzer has the advantages that the instrument assembly is greatly simplified, the POCT blood cell analyzer can completely remove related components of a cleaning fluid path in the traditional blood analysis, and the complexity and the production cost of products are greatly reduced.
However, the existing POCT blood cell analyzer is relatively simple in function, the detection is usually performed by detecting a single item, the specific operation is relatively complex, and the automation degree is low.
Disclosure of Invention
The invention provides a POCT blood cell analyzer and a kit, which can solve the problem that POCT detection can only detect a single item in the prior art.
In order to solve the technical problems, the invention adopts a technical scheme that: there is provided a kit comprising:
a case body;
The impedance detection tanks are connected with the box body and are used for carrying out impedance detection in a matching way;
the optical detection tanks are connected with the box body and are used for carrying out photoelectric detection in a matching way;
and the reagent pool is connected with the box body and is used for accommodating the reagent.
In order to solve the technical problems, the invention adopts a technical scheme that: there is provided a POCT blood cell analyzer comprising:
the detection seat is used for receiving the kit loading, and is provided with an impedance detection component and/or an optical detection component;
And the pipettor is used for sleeving a pipette head so as to perform pipetting operation on the kit.
The beneficial effects of the invention are as follows: compared with the prior art, the kit provided by the invention can support impedance detection and/or colorimetric detection and/or turbidimetric detection of a blood sample by arranging a plurality of impedance detection tanks, a plurality of optical detection tanks and a plurality of reagent tanks, has more detection items and good expandability of detection items, can dilute the sample to be detected and add the pre-treatment of the reagent, can be prepared by the pre-arranged reagent in the reagent tanks, and optimizes the POCT detection efficiency.
Drawings
For a clearer description of the technical solutions of embodiments of the invention, the drawings that are needed in the description of the embodiments will be briefly introduced below, it being obvious that the drawings in the description below are only some embodiments of the invention, from which, without inventive effort, other drawings can be obtained for a person skilled in the art, wherein:
Fig. 1 is a schematic perspective view of a POCT blood cell analyzer according to an embodiment of the present invention;
Fig. 2 is a schematic diagram of a POCT blood cell analyzer receiving kit according to an embodiment of the present invention;
Fig. 3 is a schematic diagram of an internal structure of a POCT blood cell analyzer according to an embodiment of the present invention;
FIG. 4 is a schematic diagram showing a separation state of a kit and a detection seat according to an embodiment of the present invention;
FIG. 5 is an exploded view of a kit provided by an embodiment of the present invention;
FIG. 6 is a partial cross-sectional view of a kit provided by an embodiment of the present invention;
Fig. 7 is a schematic perspective view of a detection seat of a POCT blood cell analyzer according to an embodiment of the present invention;
fig. 8 is a schematic cross-sectional structure of a detection seat of a POCT blood cell analyzer according to an embodiment of the present invention;
fig. 9 is a schematic diagram of an internal structure of a POCT blood cell analyzer according to an embodiment of the present invention;
FIG. 10 is a schematic view of a film tearing mechanism according to an embodiment of the present invention;
Fig. 11 is a schematic view of another film tearing mechanism according to an embodiment of the present invention.
Detailed Description
The following description of the embodiments of the present invention will be made clearly and completely with reference to the accompanying drawings, in which it is apparent that the embodiments described are only some embodiments of the present invention, but not all embodiments. All other embodiments, which can be made by those skilled in the art without making any inventive effort, are intended to be within the scope of the present invention.
It should be noted that, if directional indications (such as up, down, left, right, front, and rear … …) are included in the embodiments of the present invention, the directional indications are merely used to explain the relative positional relationship, movement conditions, etc. between the components in a specific posture (as shown in the drawings), and if the specific posture is changed, the directional indications are correspondingly changed.
In addition, if there is a description of "first", "second", etc. in the embodiments of the present invention, the description of "first", "second", etc. is for descriptive purposes only and is not to be construed as indicating or implying a relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defining "a first" or "a second" may explicitly or implicitly include at least one such feature. In addition, the technical solutions of the embodiments may be combined with each other, but it is necessary to base that the technical solutions can be realized by those skilled in the art, and when the technical solutions are contradictory or cannot be realized, the combination of the technical solutions should be considered to be absent and not within the scope of protection claimed in the present invention.
Referring to fig. 1 to 11, an embodiment of the present invention provides a POCT blood cell analyzer 10, wherein the POCT blood cell analyzer 10 includes a housing 11, a detection seat 200, a pipette 300, and a movement mechanism 400.
The housing 11 is provided with a display module 12, a door panel 13 and a handle portion 15. The display screen module 12 may be fixedly installed on an upper portion of a side surface of the housing 11, the display screen module 12 may be disposed in an inclined shape so as to be convenient for viewing, the display screen module 12 may be used for displaying a detection result and performing a touch operation, the housing 11 is provided with an opening 14, the door panel 13 is used for sealing the opening 14 and may be rotatably connected to a lower portion or a side portion of the housing 11, and the handle portion 15 may be disposed on a top portion of the housing 11 so as to facilitate portable movement of the POCT blood cell analyzer 10. Of course, the display screen module 12 may be omitted, and the main control module in the POCT blood cell analyzer 10 may be connected to a mobile communication device such as a mobile phone or a tablet computer by a communication method such as bluetooth connection, so as to display the detection result and corresponding touch operation by the mobile phone or the tablet computer.
The detection seat 200 is disposed on the housing 11 and is used for receiving the loading of the reagent kit 100, the detection seat 200 is provided with a plurality of impedance detection assemblies 210 and/or a plurality of optical detection assemblies 220, when the door panel 13 is opened relative to the housing 11, the detection seat 200 can be moved out of the housing 11 through a sliding assembly or a hinge assembly inside the housing 11 to receive the loading of the reagent kit 100, the impedance detection assemblies 210 are provided with electrode conductive devices 211 (see fig. 8), the electrode conductive devices 211 can be specifically elastic pins (pogo pins), and the electrode conductive devices 211 are used for being electrically connected with the impedance detection cells 120 of the reagent kit 100 after the reagent kit 100 is loaded into the detection seat 200. The detection principle of impedance detection and optical detection of blood cells by using the impedance detection component 210 and the optical detection component 220 is not related to the point of the application, and will not be described in detail in the present application. Each impedance sensing element 210 and each optical sensing element 220 can sense a separate item to obtain a specific blood cell parameter value.
The pipette 300 is disposed in the housing 11 and may be disposed above the detection seat 200, and is used for sleeving the pipette head 114 (such as tip head) to perform pipetting operation on the reagent kit 100, where pipetting operation refers to pipetting, moving and spitting operation, and the pipette 300 may also be used to perform repeated pipetting and spitting operations to form pipetting and spitting mixing effects.
The pipette 300 of the present invention may include a motor, a chamber, and a piston, wherein the motor is used to drive the piston to reciprocate in the chamber for pipetting.
The pipette 300 of the present invention may be ADP (AIR DRIVEN Pump), which is a power device with accurate volume and capable of generating positive and negative pressures.
The traditional blood cell analyzer adopts a complex set of devices such as an air pump, an air valve, a pressure chamber and the like to realize liquid preparation, counting and cleaning. The POCT blood cell analyzer provided by the application is prepared by ADP and is not required to be cleaned. In addition, ADP is a modularized component, and the structure is flexible, and the ADP is accurately driven by a motor and is little interfered by other systems.
The pipette 300 may also be used to bubble liquids in the kit 100 for mixing operations, specifically, when the pipette 300 performs mixing operations by bubbling, the pipette 300 draws air above the liquid surface and expels air below the liquid surface. Of course, an independent air pressure system can be adopted to input air to the bottom of the tank body, and additional air pressure system components are correspondingly added, so that the pipette 300 can be used for pipetting and can also be used for uniformly mixing bubbles, and the components are extremely simplified.
The motion mechanism 400 is used to make the pipette 300 and the detection seat 200 move relatively, the motion mechanism 400 may be a three-axis motion system to drive the pipette 300 to displace in the X, Y, Z direction, however, the implementation of the motion mechanism 400 is not limited thereto, and the motion mechanism 400 may also drive the detection seat 200 to displace relative to the pipette 300 or drive the pipette 300 and the detection seat 200 to displace simultaneously.
In one embodiment, the movement mechanism includes a first motor-driven component 410, a second motor-driven component 420, and a third motor-driven component 430, where the first motor-driven component 410 is used to drive the detection seat to move in the X direction; the second motor transmission assembly 420 is used for driving the pipette to move in the Y direction; the third motor transmission assembly 430 is used for driving the pipettor to move in the Z direction, the first motor transmission assembly 410, the second motor transmission assembly 420 and the third motor transmission assembly 430 can all comprise a motor 401, a transmission wheel 402, a transmission belt 403 and a transmission part 404, the motor 401 and the transmission wheel 402 are arranged at intervals, the transmission belt 403 is sleeved on the output end of the motor 401 and the transmission wheel 402, the transmission part 404 is fixed with the transmission belt 403 and is in transmission fit with the detection seat 200 or the ADP, for example, the transmission part 404 is provided with a U-shaped bayonet, and the detection seat 200 and the ADP are arranged in a sliding way through a sliding block and a sliding rail mechanism and correspondingly slide by receiving the driving force transmitted by the U-shaped bayonet.
The POCT blood cell analyzer provided by the embodiment of the invention integrates the matching components (the impedance detection cell 120 and the optical detection cell 130) and various reagents required by the test system on the kit 100, and the kit 100 is disposable, so that a huge cleaning system can be removed, and the number of components of the whole analyzer is greatly reduced, wherein the impedance detection cell 120 and the optical detection cell 130 are main cleaning objects in the traditional blood cell analyzer.
Referring to fig. 4 to 6 together, an embodiment of the present invention provides a kit 100, where the kit 100 may be a disposable kit or a reusable kit, and the kit 100 includes a kit body 110, a plurality of impedance detection cells 120, a plurality of optical detection cells 130, a reagent cell 140, a kit bottom 150, and a sealing layer 160. The kit 100 has an asymmetric structure, and is convenient to be put into the detection seat 200 in a foolproof manner.
In an embodiment, the case 110 may be large and rectangular, and the case 110 may be provided with a first insertion hole 111, where the first insertion hole 111 is used to receive the sample tube 113 for insertion; or the cartridge 110 is directly connected with a sample cell, such as an integral connection or a sleeve connection, and the sample tube 113 is used for receiving a sample load, and the sample is a blood sample. The box 110 may further be provided with a second insertion hole 112, where the second insertion hole 112 is used to mount a pipette head 114, and the pipette head 114 is used to be assembled on the pipette 300 to cooperate with pipetting operations.
A plurality of impedance detecting cells 120 are connected to the case 110 for matching impedance detection, and the number of the impedance detecting cells 120 is at least one, and two are shown in fig. 5.
A plurality of optical detecting cells 130 are connected to the case 110 for performing photoelectric detection, and the number of the optical detecting cells 130 is at least one, and two are shown in fig. 5.
The reagent reservoir 140 is connected to the case 110 for accommodating reagents such as hemolysis agent, antibody reagent, diluent, etc. The number of reagent tanks 140 may be plural to accommodate plural kinds of reagents, and of course, one reagent tank 140 may be used.
The box body 110 is arranged at the opening end of the box bottom 150, and the impedance detection cell 120 and the reagent cell 140 are accommodated in the box bottom 150; the optical detection cell 130 extends out of the cassette bottom 150; the impedance detection cell 120, the optical detection cell 130, and the reagent cell 140 each have an opening 115 communicating with the cartridge body 110, and the sealing layer 160 seals and covers the opening 115 (see fig. 10 and 11).
In an embodiment, the opening 115 corresponding to the optical detection cell 130 may be a rectangular hole 115a, the opening 115 corresponding to the reagent cell 140 may be a kidney-shaped hole, including a large number of small kidney-shaped holes 115b and a large number of two kidney-shaped holes 115c, the reagent cell 140 corresponding to the small kidney-shaped holes 115b may be used for installing various special reagents, such as hemolytic agent and antibody reagent, the reagent cell 140 corresponding to the large kidney-shaped holes 115c may be used for installing diluent and acting as a mixing cell, receiving blood samples and other reagent inputs to support dilution and mixing, the opening 115 corresponding to the impedance detection cell 120 is more specific, it is a small circular hole 115d, the existing impedance detection cell 120 is drained by negative pressure, that is, the liquid in the front cell enters the rear cell by means of cell flow through the negative pressure acting on the rear cell, and an additional negative pressure component is needed by negative pressure drainage, the application directly adopts the pipette 300 to dock the opening 115 of the small circular hole to provide positive pressure so that the liquid in the front cell 121 enters the rear cell by means of cell flow, thereby simplifying the negative pressure component 122 and reducing the device structure.
The impedance detection cell 120 is one or more groups, the impedance detection cell 120 includes a front cell 121 and a rear cell 122 which are communicated through micro-holes, and a detection device 123 for performing impedance detection in a matching manner, the detection device 123 may be an electrode sheet, the bottom 150 of the case is provided with an exposure hole corresponding to the detection device 123 to realize that the detection device 123 is electrically connected with an electrode conductive device 211 (see fig. 8) of the impedance detection assembly 210, the electrode conductive device may be an elastic thimble (pogo pin), the impedance detection cell 120 may further include a waste liquid cavity (not shown) which is communicated with the rear cell 122 to be used for receiving waste liquid, and after providing positive pressure to enable the liquid in the front cell 121 to enter the rear cell 122 in a cell flow manner, the waste liquid is finally collected by the waste liquid cavity to avoid the waste liquid from flowing away.
The optical detection cell 130 is one or more for cooperating with transmission photoelectric detection and/or scattered photoelectric detection.
The impedance detection cell 120, the optical detection cell 130, and the reagent cell 140 may be integrally formed with the case 110; or the cartridge body 110 is integrally formed with the assembly tube 116, and at least part of the impedance detection cell 120, the optical detection cell 130 and the reagent cell 140 are in butt joint with the assembly tube 116, such as a buckle connection or interference fit.
The optical detection cell 130 may be made of optical plastic, transparent plastic or glass.
In an embodiment, the kit 100 is provided with a plurality of tanks, and the plurality of tanks can be arranged in a single row, and correspondingly, the moving mechanism can be a two-dimensional moving mechanism, and the two-dimensional plane drives the ADP to perform reciprocating motion and lifting motion.
In another embodiment, the kit is provided with a plurality of tanks, the tanks are arranged in a plurality of rows, the movement mechanism is a three-dimensional movement mechanism, and ADP is driven to perform three-dimensional movement in a three-dimensional space.
According to the kit 100 provided by the invention, through arranging the plurality of impedance detection tanks 120, the plurality of optical detection tanks 130 and the plurality of reagent tanks 140, impedance detection and/or colorimetric detection and/or turbidimetric detection of a blood sample can be supported, each optical detection tank 130 and each reagent tank 140 can be matched for detecting an independent project to obtain specific blood cell parameter values, the number of the detected projects is large, the expandability of the detected projects is good, the dilution of the sample to be detected and the pretreatment of the added reagent can be formulated through the pre-packaged reagent in the reagent tank 140, and the POCT detection efficiency is optimized. In addition, the kit 100 itself can be used as a waste liquid collector, so that a reagent barrel and a waste liquid barrel which are required to be connected with a traditional blood cell analyzer are omitted, and the POCT blood cell analyzer 10 can be moved in a portable manner.
Referring to fig. 1 to 11, an embodiment of the present invention provides a POCT blood cell analyzer 10, wherein the POCT blood cell analyzer 10 includes a housing 11, a bracket 16, a detection seat 200, a pipette 300, a movement mechanism 400, a battery module 500, a power supply module, a temperature control module and a film tearing mechanism.
The housing 11 is provided with a display module 12, a door panel 13 and a handle portion 15. The display screen module 12 may be fixedly installed on the upper portion of the side surface of the housing 11, the display screen module 12 may be disposed in an inclined manner so as to be convenient for viewing, the display screen module 12 may be used for displaying a detection result and performing a touch operation, the housing 11 is provided with an opening 14, the door panel 13 is used for sealing the opening 14 and may be rotatably connected with the lower portion or the side portion of the housing 11, the detection seat 200 may be moved out of the housing 11 when the door panel 13 is opened and receive the kit 100 to be loaded, and the handle portion 15 may be disposed at the top of the housing 11 so as to facilitate the portable movement of the POCT blood cell analyzer 10. Of course, the display screen module 12 may be omitted, and the main control module in the POCT blood cell analyzer 10 may be connected to a mobile communication device such as a mobile phone or a tablet computer by a communication method such as bluetooth connection, so as to display the detection result and corresponding touch operation by the mobile phone or the tablet computer.
The detection seat 200 is arranged in the shell 11 and is used for receiving the loading of the kit 100, wherein the detection seat 200 is arranged in a sliding way relative to the shell 11, and the detection seat 200 is used for receiving the loading of the kit 100 when the detection seat 200 slides out of the shell 11; or the detecting seat 200 is hinged relative to the shell 11, and the detecting seat 200 is used for receiving the kit 100 when the detecting seat 200 is unscrewed from the shell 11.
The detection seat 200 is provided with a plurality of impedance detection components 210 and/or a plurality of optical detection components 220, the impedance detection components 210 comprise electrode conductive devices 211 (see fig. 8), the electrode conductive devices 211 can be specifically elastic ejector pins (pogo pins), the kit 100 is provided with detection devices 123, the detection devices 123 can be electrode plates, the electrode conductive devices 211 are in electrical contact with the detection devices 123 when the kit 100 is loaded into the detection seat 200, and the optical detection components 220 comprise light emitting components and light receiving components which are arranged at intervals. The detection principle of detecting the blood cells by using the impedance detection component 210 and the optical detection component 220 does not relate to the point of the application, and is not described in detail in the present application.
The pipette 300 is disposed in the housing 11 and above the detection seat 200, and is used for sleeving a pipette head 114 (such as a tip head) to perform pipetting operation on the kit 100. The pipette 300 of the present application may include a motor, a chamber, and a piston, wherein the motor is used to drive the piston to reciprocate in the chamber for pipetting. The pipette 300 of the present application may be ADP (AIR DRIVEN Pump), which is a power device with accurate volume and capable of generating positive and negative pressures. The traditional blood cell analyzer adopts a complex set of devices such as an air pump, an air valve, a pressure chamber and the like to realize liquid preparation, counting and cleaning. The POCT blood cell analyzer provided by the application is prepared by ADP and is not required to be cleaned. In addition, ADP is a modularized component, and the structure is flexible, and the ADP is accurately driven by a motor and is little interfered by other systems.
The support 16 is provided in the housing 11, and ADP is mounted on the support 16 by the moving mechanism 400.
The pipetting operation refers to pipetting, moving and spitting operations, and specifically comprises the following steps:
Dispensing a blood sample to a specific reagent reservoir 140, which may be preloaded with a diluent, the specific reagent reservoir 140 may be a reagent reservoir 140 having a large kidney-shaped aperture 115 c;
adding reagents in other reagent cells 140 to a specific reagent cell 140 to mix to form a sample to be detected, and the other reagent cell 140 may be a reagent cell 140 having a small kidney-shaped hole 115 b;
The sample to be detected is moved into the impedance detection cell 120 and/or the optical detection cell 130 for impedance detection and/or optical detection.
The motion mechanism 400 is disposed in the housing 11 and is used for moving the pipette 300 relative to the detection seat 200 to support the pipetting operation, the motion mechanism 400 may be a three-axis motion system to drive the pipette 300 to displace in the direction X, Y, Z, however, the implementation of the motion mechanism 400 is not limited thereto, and the motion mechanism 400 may also drive the detection seat 200 to displace relative to the pipette 300 or drive the pipette 300 and the detection seat 200 to displace simultaneously.
The battery module 500 is electrically connected with the detecting base 200, the movement mechanism 400 and the pipette 300, and the battery module 500 is arranged to facilitate the use of the POCT blood cell analyzer 10 in different places, such as outdoors. In order to facilitate the disassembly and assembly of the battery module 500, a battery cavity may be disposed on the outer surface of the housing 11, the battery module 500 is assembled with the battery cavity in a fastening manner, or the POCT blood cell analyzer is provided with a battery cavity and a cover plate, the battery module is assembled with the battery cavity in a fastening manner and is covered by the cover plate, the cover plate may be an instrument housing, or may be a panel on any side or top of the instrument, and the two modes can realize the convenient disassembly and assembly of the battery module 500. Of course, the POCT blood cell analyzer 10 further comprises a power supply module electrically connected to the detection seat 200, the movement mechanism 400 and the pipette 300 for connecting to the mains.
The temperature control module is attached to the detecting seat 200 to provide a detecting temperature. As shown in fig. 7, the temperature control module may be a heating film 510 attached to the bottom surface or the side surface of the detection seat 200, or the temperature control module may be a heating rod, and correspondingly, the detection seat 200 is provided with an assembly hole for receiving the heating rod; the temperature control module may also be a peltier 520, where the peltier 520 is used to heat or cool the heating base. The traditional POCT blood cell analyzer depends on a constant temperature environment of a laboratory, is inconvenient to use in a natural environment, and can be independently heated or cooled by arranging a temperature control module, and the environmental temperature has little influence on detection.
In one embodiment, the pipette 300 comprises a motor, a chamber, and a piston, wherein the motor is used for driving the piston to reciprocate in the chamber for pipetting.
The pipette 300 may also be used to provide positive pressure to cause flow of liquid within the impedance detection cell 120 of the kit 100, i.e., by providing positive pressure to the front cell 121 to cause liquid within the front cell 121 to flow through the microwells to the back cell 122. The pipette 300 is also used for sucking and spitting to realize the uniform mixing operation; the pipette 300 may also be used to inflate bubbles into a liquid to achieve a blending operation.
The film tearing mechanism is used for tearing the sealing layer 160 on the surface of the kit 100; or a film tearing mechanism for puncturing the sealing layer 160 of the surface of the kit 100.
As shown in fig. 10, the film tearing mechanism may be a fixed hook 610, where the hook 610 is used to hook the tab 162 of the sealing layer 160 when the detection seat 200 receives the kit 100 after being loaded into the casing 11, so as to implement automatic film tearing, and the hook 610 may be an L-shaped plate, and the tab 162 is provided with a corresponding hook hole. If the manual film tearing mode is adopted, namely, the sealing layer 160 is torn off, the kit 100 is installed in the detection seat 200, and due to operation uncertainty, the reagent pre-installed in the kit 100 is easily sprayed out, so that the normal detection is affected by insufficient reagent quantity.
As shown in fig. 11, in another embodiment, the film tearing mechanism includes a plate body 621, a film breaking column 622 disposed on one surface of the plate body 621, and a driving mechanism 623 for driving the plate body 621 to lift, where the film breaking column 621 corresponds to the cell body of the kit 100, the driving mechanism 623 is used for driving the plate body 621 such that the film breaking column 622 pierces the sealing layer 160 on the surface of the kit 100, the free end of the film breaking column 622 has a gradually reduced cross-sectional area, the film breaking column 622 may be in a conical shape, and the driving mechanism 623 may be a motor and a driving belt or a motor and a gear.
The embodiment of the invention also provides a detection method based on the POCT blood cell analyzer 10, which comprises the following steps:
the receiving kit 100 is arranged in the detection seat 200, wherein the kit 100 comprises a plurality of impedance detection cells 120 and/or a plurality of optical detection cells 130 for matching impedance and/or photoelectric detection, the kit 100 further comprises a plurality of reagent cells 140, the reagent cells 140 are used for accommodating a plurality of reagents, a sample tube is further arranged on the kit 100, and a blood sample is arranged in the sample tube;
dispensing a blood sample into a specific reagent reservoir 140 by a pipette 300, i.e. automatic blood separation by the device;
Adding the reagents in the other reagent pools 140 into the specific reagent pools 140 through the pipetter 300 to be mixed so as to form a sample to be detected, namely, realizing automatic reagent adding through equipment;
The sample to be detected is moved into the impedance detection cell 120 and/or the optical detection cell 130 by the pipette 300 to perform impedance detection and/or optical detection.
According to the POCT blood cell analyzer and the detection method, the blood sample can be automatically distributed and the reagent can be automatically added through the cooperation of the motion mechanism and the liquid shifter, so that the POCT detection efficiency is optimized. In the existing detection method, the reagent is manually added, and the mixture is poured into an instrument for detection after being mixed evenly.
Wherein, the step of receiving the kit 100 into the cartridge 200 comprises:
Tearing the sealing layer 160 of the surface of the kit 100 using a film tearing mechanism; or the sealing layer 160 on the surface of the kit 100 may be pierced by a film tearing mechanism.
Wherein the step of dispensing the blood sample into the specific reagent reservoir 140 by the pipette 300 is preceded by:
The pipette 300 is inserted and docked with the pipette head 114 preset on the kit 100, so that the pipette 300 can only contact the blood sample, the reagent and the sample to be detected through the pipette head 114 when performing pipetting operation, and pollution to the pipette 300 is avoided.
Wherein, when impedance detection is performed, positive pressure is provided by the pipette 300 to promote the flow of a sample to be detected in the impedance detection cell, and the multiplexing pipette 300 can reduce the need of an additional negative pressure device for impedance detection drainage in the prior art, thereby reducing product components.
The POCT blood cell analyzer and the detection method provided by the embodiment can realize automatic blood sample distribution and automatic reagent addition through the cooperation of the motion mechanism and the liquid shifter, and optimize POCT detection efficiency.
The embodiment of the invention also provides a driving device for liquid flow of the impedance detection cell 120, the driving device comprises a pressure source, the impedance detection cell 120 comprises a front cell 121, a rear cell 122 and a detection device 123 for matching impedance detection, which are communicated through micropores, and the pressure source is used for applying pressure to the front cell 121 so that the liquid in the front cell 121 flows to the rear cell 122 through the micropores.
The pressure source may specifically be a pipette 300, the pipette 300 being used for pipetting when the pipette head 114 is sleeved and the pipette 300 also being used for applying pressure when the pipette head 114 is not sleeved. The pipette 300 of the present application may be ADP (AIR DRIVEN Pump), which is a power device with accurate volume and capable of generating positive and negative pressures. The traditional blood cell analyzer adopts a complex set of devices such as an air pump, an air valve, a pressure chamber and the like to realize liquid preparation, counting and cleaning. The POCT blood cell analyzer provided by the application is prepared by ADP and is not required to be cleaned. In addition, ADP is a modularized component, and the structure is flexible and is little interfered by other systems.
The pipette 300 comprises a motor, a cavity and a piston, wherein the motor is used for driving the piston to reciprocate in the cavity to perform pipetting operation.
The top end of the front tank 121 is provided with an opening 115, and the opening 115 is used for tightly abutting against the free end of the pipette 300 to receive pressure input into the front tank 121. The opening 115 may be in the shape of a small circular hole 115d to facilitate a tight-fitting interface with the free end of the pipette 300.
The embodiment of the invention also provides a POCT blood cell analyzer, which comprises a shell 11, a detection seat 200, a pressure source, a movement mechanism 400, a temperature control module, a storage battery module 50 and a power supply module.
The housing 11 is provided with a display module 12, a door panel 13 and a handle portion 15. The display screen module 12 can be fixedly installed on the upper portion of the side surface of the casing 11, the display screen module 12 can be obliquely arranged so as to be convenient to watch, the display screen module 12 can be used for displaying detection results and performing touch operation, the casing 11 is provided with an opening 14, the door plate 13 is used for sealing the opening 14 and can be rotatably connected with the lower portion of the casing 11, the detection seat 200 can be moved out of the casing 11 when the door plate 13 is opened and used for receiving the kit 100 to be loaded, and the handle portion 15 can be arranged on the top of the casing 11 so as to facilitate the portable movement of the POCT blood cell analyzer 10. Of course, the display screen module 12 may be omitted, and the main control module in the POCT blood cell analyzer 10 may be connected to a mobile communication device such as a mobile phone or a tablet computer by a communication method such as bluetooth connection, so as to display the detection result and corresponding touch operation by the mobile phone or the tablet computer.
The detection seat 200 is arranged in the shell 11 and is used for receiving the loading of the kit 100, the kit 100 comprises an impedance detection pool 120, the impedance detection pool 120 comprises a front pool 121 and a rear pool 122 which are communicated through micropores and a detection device 123 used for carrying out impedance detection in a matched mode, the detection seat 200 is provided with an impedance detection component 210 corresponding to the impedance detection pool 120, the impedance detection component 210 comprises an electrode conductive device 211, and the electrode conductive device 211 is in electrical contact with the detection device 123 when the kit 100 is loaded into the detection seat 200.
A pressure source is provided within the housing 11 for applying pressure to the front sump 121 such that liquid within the front sump 121 flows through the micropores to the back sump 122. The pressure source may specifically be a pipette 300, the pipette 300 being used for pipetting when the pipette head 114 is sleeved and the pipette 300 also being used for applying pressure when the pipette head 114 is not sleeved. The pipette 300 of the present application may be ADP (AIR DRIVEN Pump), which is a power device with accurate volume and capable of generating positive and negative pressures. The traditional blood cell analyzer adopts a complex set of devices such as an air pump, an air valve, a pressure chamber and the like to realize liquid preparation, counting and cleaning. The POCT blood cell analyzer provided by the application is prepared by ADP and is not required to be cleaned. In addition, ADP is a modularized component, and the structure is flexible and is little interfered by other systems.
The pipette 300 comprises a motor, a cavity and a piston, wherein the motor is used for driving the piston to reciprocate in the cavity so as to perform pipetting operation, sucking and spitting uniform mixing operation or bubble uniform mixing.
As shown in fig. 5, the top end of the front tank 121 is provided with an opening 115, and the opening 115 is used for tight-fitting and abutting with the free end of the pipette 300 to receive pressure input into the front tank 121. The opening 115 may be in the shape of a small circular hole 115d to facilitate a tight-fitting interface with the free end of the pipette 300.
In particular embodiments, the pipette 300 may include a first syringe and a second syringe in a sliding nested arrangement, the free end of the second syringe being retracted from the free end of the first syringe such that the free end of the first syringe is exposed and thereby cup jointed to the pipette head 114, the second syringe being moved toward the free end of the first syringe to separate the pipette head 114.
The motion mechanism 400 is arranged in the shell 11 and is used for enabling the pipettor 300 to move relative to the detection seat 200 so as to carry out pipetting operation; the temperature control module is attached to the detection seat 200 to provide a detection temperature; the battery module 500 is electrically connected to the detection base 200, the movement mechanism 400, and the pipette 300; and/or the power supply module is electrically connected with the detection seat 200, the movement mechanism 400 and the pipettor 300 and is used for connecting with the mains supply.
According to the POCT blood cell analyzer and the liquid flow driving device of the impedance detection cell, provided by the embodiment of the invention, the liquid in the front cell flows to the back cell through the micropores by applying pressure to the front cell, and an additional negative pressure generating device is not needed, so that the product component structure can be simplified.
The foregoing is only the embodiments of the present invention, and therefore, the patent scope of the invention is not limited thereto, and all equivalent structures or equivalent processes using the descriptions of the present invention and the accompanying drawings, or direct or indirect application in other related technical fields, are included in the scope of the invention.
Claims (9)
1. A POCT blood cell analyzer, the POCT blood cell analyzer comprising:
the detection seat is used for receiving the kit to be loaded, and is provided with an impedance detection component and an optical detection component, or is provided with an impedance detection component;
A pipette for sleeving a pipette head to perform pipetting operation on the kit;
wherein, the kit includes:
a case body;
The impedance detection tanks are connected with the box body and are used for carrying out impedance detection in a matching way;
the optical detection tanks are connected with the box body and are used for carrying out photoelectric detection in a matching way;
the reagent pool is connected with the box body and is used for accommodating a reagent;
The box body is provided with a second inserting hole, the second inserting hole is used for installing a pipette head, and the pipette head is used for being assembled on the pipettor to be matched with the pipettor for pipetting operation;
The pipette is also used for providing positive pressure to the impedance detection cell when the pipette head is not sleeved, so that a sample to be detected in the impedance detection cell flows.
2. The POCT blood cell analyzer of claim 1, wherein:
The box body is provided with a first insertion hole which is used for receiving the sample tube to be inserted; or alternatively
The cartridge is connected with a sample tube for receiving a sample charge.
3. The POCT blood cell analyzer of claim 1, wherein:
The kit further comprises a kit bottom, and the kit body is arranged at the opening end of the kit bottom;
The impedance detection tank and the reagent tank are accommodated in the box bottom;
The optical detection pool extends out of the box bottom.
4. The POCT blood cell analyzer of claim 1, wherein:
the impedance detection cell, the optical detection cell and the reagent cell are all provided with opening parts communicated with the box body, a sealing layer is arranged on the box body, and the opening parts are covered by the sealing layer in a sealing way.
5. A POCT blood cell analyzer as claimed in claim 3, characterized in that:
The impedance detection pond is one or more groups, the impedance detection pond includes preceding pond, back pond and the detection electrode that is used for the cooperation to carry out impedance detection through micropore intercommunication, the box bottom corresponds the detection electrode is equipped with corresponding exposure hole in order to realize detection electrode and conductive electrode electricity are connected.
6. The POCT blood cell analyzer of claim 5, wherein:
the impedance detection cell further includes a waste chamber in communication with the back cell for receiving waste.
7. The POCT blood cell analyzer of claim 1, wherein:
the optical detection tanks are one or more and are used for carrying out transmission photoelectric detection and/or scattered photoelectric detection in a matching way, and the optical detection tanks are made of optical plastics or glass.
8. The POCT blood cell analyzer of claim 1, wherein:
The optical detection tanks are one or more and are used for carrying out transmission photoelectric detection and/or scattered photoelectric detection in a matched mode, and the optical detection tanks are made of transparent plastics.
9. The POCT blood cell analyzer of claim 1, wherein:
The impedance detection pool, the optical detection pool, the reagent pool and the box body are integrally formed; or alternatively
The integrated cylinder on the box body is provided with an assembly cylinder, and at least part of the impedance detection pool, the optical detection pool and the reagent pool are in butt joint connection with the assembly cylinder.
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| CN202010260842.6A CN113495086B (en) | 2020-04-03 | 2020-04-03 | POCT blood cell analyzer and kit |
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| CN108732135A (en) * | 2017-11-20 | 2018-11-02 | 重庆中元汇吉生物技术有限公司 | A kind of blood cell and analysis of protein device |
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| GB494182A (en) * | 1937-05-14 | 1938-10-21 | William Brewer | Improvements in syphon bottles for aerated liquids |
| EP2209904B1 (en) * | 2007-10-10 | 2017-03-01 | Pocared Diagnostics Ltd. | System for conducting the identification of bacteria in urine |
| CN202204820U (en) * | 2011-08-12 | 2012-04-25 | 石家庄禾柏生物技术股份有限公司 | Integrated combined kit |
| US20160069919A1 (en) * | 2011-09-25 | 2016-03-10 | Theranos, Inc. | Systems and methods for multi-analysis |
| GB2532790B (en) * | 2014-11-28 | 2017-10-04 | Porvair Filtration Group Ltd | Modified pipette tips for chromatin immunoprecipitation assay |
| CN106018818A (en) * | 2016-07-01 | 2016-10-12 | 安邦（厦门）生物科技有限公司 | Time-resolved immunofluorescent quantitative detection method and kit used by time-resolved immunofluorescent quantitative detection method |
| US10427162B2 (en) * | 2016-12-21 | 2019-10-01 | Quandx Inc. | Systems and methods for molecular diagnostics |
| CN106770261A (en) * | 2017-02-08 | 2017-05-31 | 北京爱富迪医药科技发展有限公司 | A kind of kit for water sample lead field quick detection |
| CN109100512A (en) * | 2018-08-02 | 2018-12-28 | 宁波奥丞生物科技有限公司 | A kind of chemical luminescence reagent kit detecting EGFR |
| CN109932519A (en) * | 2019-04-19 | 2019-06-25 | 深圳市理邦精密仪器股份有限公司 | Blood test device |
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| CN104053983A (en) * | 2011-09-13 | 2014-09-17 | 奥雷科有限公司 | Diagnostic apparatus |
| CN108732135A (en) * | 2017-11-20 | 2018-11-02 | 重庆中元汇吉生物技术有限公司 | A kind of blood cell and analysis of protein device |
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