[go: up one dir, main page]
More Web Proxy on the site http://driver.im/

CN113453720A - 双配体药物偶联体及其用途 - Google Patents

双配体药物偶联体及其用途 Download PDF

Info

Publication number
CN113453720A
CN113453720A CN202080011608.8A CN202080011608A CN113453720A CN 113453720 A CN113453720 A CN 113453720A CN 202080011608 A CN202080011608 A CN 202080011608A CN 113453720 A CN113453720 A CN 113453720A
Authority
CN
China
Prior art keywords
cell
cells
tumor
conjugate compound
linker
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202080011608.8A
Other languages
English (en)
Inventor
黄保华
谭巍
戴建
王中波
刘小栋
胡新礼
谢雪原
邵军
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tong Yi Medicine Suzhou Co ltd
Original Assignee
Tong Yi Medicine Suzhou Co ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tong Yi Medicine Suzhou Co ltd filed Critical Tong Yi Medicine Suzhou Co ltd
Publication of CN113453720A publication Critical patent/CN113453720A/zh
Pending legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/542—Carboxylic acids, e.g. a fatty acid or an amino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/545—Heterocyclic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/55—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being also a pharmacologically or therapeutically active agent, i.e. the entire conjugate being a codrug, i.e. a dimer, oligomer or polymer of pharmacologically or therapeutically active compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/65—Peptidic linkers, binders or spacers, e.g. peptidic enzyme-labile linkers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

一种偶联体化合物或其药学上可接受的盐，所述偶联体化合物或其药学上可接受的盐包含有效载荷和两个靶向分子。还涉及一种药物组合物，所述药物组合物包含偶联体化合物或其药学上可接受的盐。另外涉及一种用于向有需要的对象递送有效载荷的方法以及一种治疗疾病的方法，所述方法均包括向所述对象施用治疗有效量的偶联体化合物或其药学上可接受的盐，或者药物组合物。

Description

PCT国内申请，说明书已公开。

Claims (46)

  1. PCT国内申请，权利要求书已公开。
CN202080011608.8A 2019-01-30 2020-01-31 双配体药物偶联体及其用途 Pending CN113453720A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
CN2019073962 2019-01-30
CNPCT/CN2019/073962 2019-01-30
CN2020100485934 2020-01-16
CN202010048593 2020-01-16
PCT/CN2020/074117 WO2020156513A1 (zh) 2019-01-30 2020-01-31 双配体药物偶联体及其用途

Publications (1)

Publication Number Publication Date
CN113453720A true CN113453720A (zh) 2021-09-28

Family

ID=71840373

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202080011608.8A Pending CN113453720A (zh) 2019-01-30 2020-01-31 双配体药物偶联体及其用途

Country Status (13)

Country Link
US (1) US20220175761A1 (zh)
EP (1) EP3903825A4 (zh)
JP (1) JP7546574B2 (zh)
KR (1) KR20210119413A (zh)
CN (1) CN113453720A (zh)
AU (1) AU2020214507A1 (zh)
BR (1) BR112021015109A2 (zh)
IL (1) IL285148A (zh)
MX (1) MX2021009199A (zh)
PH (1) PH12021551792A1 (zh)
SG (1) SG11202108182RA (zh)
TW (1) TW202100183A (zh)
WO (1) WO2020156513A1 (zh)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116789733A (zh) * 2022-07-05 2023-09-22 上海药明合联生物技术有限公司 偶联连接子

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022099762A1 (zh) * 2020-11-12 2022-05-19 博瑞生物医药（苏州）股份有限公司 一种抗体偶联物中间体及其制备方法
WO2022268202A1 (zh) * 2021-06-25 2022-12-29 同宜医药（苏州）有限公司 配体药物偶联物及其应用
US11806405B1 (en) 2021-07-19 2023-11-07 Zeno Management, Inc. Immunoconjugates and methods
EP4420681A1 (en) * 2021-10-19 2024-08-28 Coherent Biopharma (Suzhou), Limited Conjugate drug preparation, preparation method therefor and use thereof
TW202404643A (zh) * 2022-04-20 2024-02-01 大陸商同宜醫藥（蘇州）有限公司 化合物及用途
IL316421A (en) * 2022-04-27 2024-12-01 Daiichi Sankyo Co Ltd Combination of an antibody-drug conjugate with an EZH1 and/or EZH2 inhibitor
TW202410923A (zh) * 2022-09-09 2024-03-16 大陸商同宜醫藥（蘇州）有限公司 放射性核種偶聯藥物及其藥物組成物和應用
WO2024105197A1 (en) * 2022-11-17 2024-05-23 Vincerx Pharma Gmbh Small molecule-drug-conjugates cleavable in a tumor microenvironment
CN117442704A (zh) * 2022-12-09 2024-01-26 中山大学孙逸仙纪念医院 一种治疗前列腺癌的药物组合及其应用
WO2024131944A1 (zh) * 2022-12-23 2024-06-27 同宜医药（苏州）有限公司 药物组合物及其制备方法和用途
WO2024222803A1 (zh) * 2023-04-26 2024-10-31 同宜医药（苏州）有限公司 一种配体-药物偶联体在治疗癌症中的用途
WO2024239281A1 (en) * 2023-05-24 2024-11-28 Hangzhou Seehe Biotechnology Co., Ltd Targeted treatment of prostate cancers and other tumors by an antibody-drug conjugate

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106466484A (zh) * 2015-08-11 2017-03-01 同宜医药开曼有限公司 一种具有细胞内吞介导功能的多靶向配体-药物偶联体
CN107412794A (zh) * 2017-04-17 2017-12-01 中国医学科学院北京协和医院 双靶点显像分子探针及其制备方法和应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006093991A1 (en) 2005-03-02 2006-09-08 The Cleveland Clinic Foundation Compounds which bind psma and uses thereof
CA2755965C (en) 2009-03-19 2019-04-16 The Johns Hopkins University Psma-targeting compounds and uses thereof
SG10201706618UA (en) 2012-11-15 2017-09-28 Endocyte Inc Conjugates for treating diseases caused by psma expressing cells
EP3265471A1 (en) 2015-03-01 2018-01-10 Endocyte, Inc. Methods of treating cancer with a psma ligand-tubulysin compound
DK3334500T3 (da) 2015-08-11 2021-06-21 Coherent Biopharma I Ltd Multiligand-lægemiddelskonjugater og anvendelser deraf
CN106433063A (zh) 2015-08-12 2017-02-22 普立万聚合体（上海）有限公司 含有蓝光阻隔添加剂的混合物
WO2017205447A1 (en) 2016-05-24 2017-11-30 Endocyte, Inc. Methods of treating cancer with a psma ligand-tubulysin compound
CN107970453A (zh) * 2017-12-05 2018-05-01 北京林业大学 一种叶酸修饰的果胶纳米粒子的双靶向递送方法

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106466484A (zh) * 2015-08-11 2017-03-01 同宜医药开曼有限公司 一种具有细胞内吞介导功能的多靶向配体-药物偶联体
CN107412794A (zh) * 2017-04-17 2017-12-01 中国医学科学院北京协和医院 双靶点显像分子探针及其制备方法和应用

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
MATTHIAS EDER等: "Preclinical evaluation of a bispecific low-molecular heterodimer targeting both PSMA and GRPR for improved PET imaging and therapy of prostate cancer", THE PROSTATE, vol. 74, no. 6, pages 659 - 668, XP002783749, DOI: 10.1002/pros.22784 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116789733A (zh) * 2022-07-05 2023-09-22 上海药明合联生物技术有限公司 偶联连接子

Also Published As

Publication number Publication date
PH12021551792A1 (en) 2022-03-21
EP3903825A4 (en) 2023-01-11
US20220175761A1 (en) 2022-06-09
EP3903825A1 (en) 2021-11-03
IL285148A (en) 2021-09-30
BR112021015109A2 (pt) 2022-01-11
JP2022518924A (ja) 2022-03-17
SG11202108182RA (en) 2021-08-30
MX2021009199A (es) 2021-09-08
KR20210119413A (ko) 2021-10-05
WO2020156513A1 (zh) 2020-08-06
AU2020214507A1 (en) 2021-08-19
JP7546574B2 (ja) 2024-09-06
TW202100183A (zh) 2021-01-01

Similar Documents

Publication Publication Date Title
CN113453720A (zh) 双配体药物偶联体及其用途
JP7573401B2 (ja) 多リガンド－薬物複合体及びその使用
US20150320799A1 (en) Chimeric antigen receptor-expressing t cells as anti-cancer therapeutics
US20180078656A1 (en) Cryptophycin-based antibody-drug conjugates with novel self-immolative linkers
US20240358843A1 (en) Ligand-drug conjugate and use thereof
KR101286721B1 (ko) 폴리-시스테인 펩티드 융합 재조합 알부민 및 이의 제조방법
CN106466485B (zh) 一种具有细胞内吞介导功能的靶向配体-药物偶联体
KR102436012B1 (ko) 항암제 프로드러그 컨쥬게이트의 새로운 용도
CA3127903A1 (en) Bi-ligand drug conjugate and use thereof
RU2820346C2 (ru) Билигандный конъюгат лекарственного средства и его применение

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
REG Reference to a national code

Ref country code: HK

Ref legal event code: DE

Ref document number: 40052006

Country of ref document: HK

SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination