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CN1133418C - 含有杀微生物的活性成分的浓缩液体制剂 - Google Patents

含有杀微生物的活性成分的浓缩液体制剂 Download PDF

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CN1133418C
CN1133418C CNB971950997A CN97195099A CN1133418C CN 1133418 C CN1133418 C CN 1133418C CN B971950997 A CNB971950997 A CN B971950997A CN 97195099 A CN97195099 A CN 97195099A CN 1133418 C CN1133418 C CN 1133418C
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CN1220597A (zh
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D���º�˹
D·奥赫斯
ε¶
M·施奈德尔
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BASF Schweiz AG
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Abstract

本发明描述了浓缩液体制剂(a)，其含有(a1)1-80%(重量)的杀微生物活性成分，(a2)20-99%(重量)的一元-或二元醇或其混合物，和浓缩液体制剂(b)含有(b1)5.1-30%(重量)的杀微生物活性成分，(b2)0-80%(重量)的磺酸盐，(b3)1-60%(重量)的C1-C11单羧酸或C3-C12双-或多羧酸，(b4)0-90%(重量)的一元-或二元醇或其混合物，和水加至100%，(b2)或(b4)中的一个总是必须存在。将根据本发明的制剂用作化妆品、居家用品或手消毒剂的杀微生物活性成分，用作居家用品和化妆品的防腐剂和用作织物或皮肤以及硬表面的消毒剂和净化剂。

Description

含有杀微生物的活性成分的浓缩液体制剂
本发明涉及含有杀微生物的活性成分的液体制剂，涉及将该制剂在化妆品、家居用品或手消毒剂中用于杀微生物的活性成分和作为家居用品和化妆品的防腐剂。
本发明涉及
浓缩液体制剂(a)，其含有
(a1)1-80％(重量)的杀微生物活性成分，
(a2)20-99％(重量)的一元-或二元醇或其混合物，
和
浓缩液体制剂(b)，其含有
(b1)5.1-30％(重量)的杀微生物活性成分，
(b2)0-80％(重量)的磺酸盐
(b3)1-60％(重量)的C1-C11单羧酸或C3-C12双-或多羧酸；
(b4)0-90％(重量)的一元-或二元醇或其混合物，
和
水加至100％，(b2)或(b4)中的一个总是必须存在。
浓缩液体制剂(a)优选含有
(a1)20-70％(重量)的杀微生物活性成分，
(a2)30-80％(重量)的一元-或二元醇或其混合物，
制剂(b)优选含有
(b1)10-30％(重量)的杀微生物活性成分，
(b2)0-80％(重量)的磺酸盐
(b3)1-60％(重量)的C1-C11单羧酸或C3-C12双-或多羧酸；
(b4)0-90％(重量)的一元-或二元醇或其混合物，
和
水加至100％。
成分(a1)或(b1)为，特别为，下式的2-羟基二苯基醚
Figure C9719509900051
其中
Y为氯或溴，
Z为SO2H、NO2或C1-C4烷基
r为0-3，
o为0-3，
p为0或1，
m为0或1和
n为0或1。
非常重要的式(1)化合物为这样的化合物，其中：
Y为氯或溴，
m为0，
n为0或1，
o为1或2，
r为1或2和
p为0。
特别非常重要的式(1)化合物这样的化合物，其中为：
Y为氯，
m为0，
n为0，
o为1，
r为2和
p为0。
特别非常优选化合物为下式：
Figure C9719509900061
其它与成分(a1)或(b1)相关的适当的杀微生物活性成分为：
-苯酚衍生物，
-二苯基化合物，
-苄醇，
-氯己定，
-C12-C14烷基甜菜碱和C8-C18脂肪酸酰氨基烷基甜菜碱，
-两性表面活性剂，
-三卤代-N-碳酰苯胺，
-四价铵盐。
苯酚衍生物优选下式化合物：
Figure C9719509900062
其中
R1为氢、羟基、C1-C4烷基、氯、硝基、苯基或苄基，
R2为氢、羟基、C1-C6烷基或卤素，
R3为氢、C1-C6烷基、羟基、氯、硝基或以碱金属盐或铵盐形式存在的硫，
R4为氢或甲基和
R5为氢或硝基。
卤素为溴或优选氯。
这样的化合物的例子有氯苯酚(o-，m-，p-)，2，4-二氯苯酚，对-硝基苯酚、苦味酸、二甲基苯酚、对-氯代-间-二甲基苯酚、甲酚(o-，m-，p-)、对-氯代-间-甲酚、邻苯二酚、间苯二酚、4-正-己基间苯二酚、焦没食子酚、间苯三酚、香芹酚、百里酚、对-氯百里酚、邻-苯基苯酚、邻-苄基苯酚、对-氯代-邻-苄基苯酚和4-苯酚磺酸。
二苯基化合物优选下式化合物：
其中
X为硫或亚甲基基团，
R1和R’1为羟基和
R2、R’2、R3、R’3、R4、R’4、R5和R’5相互独立地为氢或卤素。
式(4)化合物的例子为六氯苯、四氯-苯、二氯苯、2，3-二羟基-5，5’-二氯苯基硫化物、2，2’-二羟基-3，3’，5，5’-四氯二苯基硫化物、2，2’-二羟基-3，3’，5，5’，6，6’-六氯二苯基硫化物和3，3’-二溴-5，5’-二氯-2，2’-二羟基二苯基胺。
苄醇优选下式：其中
R1、R2、R3、R4和R5相互对立地为氢或氯。
式(5)化合物的例子为苄醇、2，4-、3，5-或2，6-二氯苄醇和三氯苄醇。
氯己定可以就这样使用或以其有机和无机酸盐的形式使用。
可能提到的C8-C18脂肪酸酰胺基烷基甜菜碱的例子为椰子C8-C18脂肪酸酰胺基丙基甜菜碱。
适当的两性表面活性剂的例子为C12烷氨基-、C1-C3烷烃基羧酸，如烷氨基乙酸或烷氨基丙酸。
三卤代-N-碳酰苯胺为，特别为下式：
其中
Hal为氯或溴，
n和m为1或2，
n+m为3。
四价铵盐为，特别为下式：
其中
R7、R8、R9和R10相互独立地为C1-C18烷基、C1-C18烷氧基或苯基-C1-C5烷基和
Hal为氯或溴。
最特别优选下式化合物：
其中
n为7-17的数。
与成分(a2)和(b4)相关的一元醇为线状或有支链的C2-C18醇，例如，乙醇、正-丙醇、异丙醇、丁醇、月桂醇、鲸蜡醇、2-乙基己醇、1，1，3，3-四甲基丁醇、壬-2-醇、异壬醇、三甲基己醇、三甲基壬醇、葵醇、C9-C11氧代醇、三葵基醇、异三葵基醇或具有8-18碳原子的线状伯醇(Alfol types)。Alfol types的一些代表为Alfol(8-10)、Alfol(9-11)、Alfol(10-14)、Alfol(12-13)或Alfol(16-18)。
与本发明相关的液体制剂中使用的其它物质为下面通式的一元醇：
Figure C9719509900092
其中
X为卤素原子，
Y为式-O-(CH2)m-或-CH2-基团或直接为键；
n为0-5；
m为1-3。
优选的式(9)化合物为下述化合物，其中
Y为-O-(CH2)m-和
n＝0。
如果二元醇被用作成分(a2)，则烷基部分有(特别应有)2-6个碳原子，例如，乙二醇、1，2-或1，3-丙二醇、1，3-、1，4-或2，3-丁二醇、1，5-戊二醇和1，6-己二醇。1，2-丙二醇(丙二醇)为优选。
适当的磺酸盐(成分(b2))为，特别为，其萜类化合物或单-或双中心芳香族化合物的盐，如樟脑、甲苯、二甲苯、异丙基苯或萘酚的磺酸盐。
作为饱和或不饱和的C3-C12双-或聚羧酸的成分(b3)的适当的例子为丙二酸、琥珀酸、戊二酸、己二酸、庚二酸、辛二酸、壬二酸、葵二酸、十一烷-和十二烷二羧酸、富马酸、马来酸、酒石酸和马来酸、羟乙酸(乙醇酸)、a’-羟丙酸(乳酸)、柠檬酸和乌头酸。
脂肪族饱和和不饱和C1-C11单羧酸的例子为乙酸、丙酸、己酸、葵酸和十一烯酸。
其它适当的物质为氨基羧酸，如乙烯基二氨四乙酸、羟乙基乙烯基二氨四乙酸和氮三乙酸；环脂肪族羧酸，如campheric acid；芳香族羧酸，如苯甲酸、苯乙酸、苯氧乙酸和zimanic acid、2-，3-和4-羟基苯甲酸、anilic acid和邻-、间-和对-氯苯乙酸和邻-、间-和对-氯苯氧乙酸；无机酸的碱金属盐和铵盐，如盐酸、硫酸、磷酸、C1-C10烷基磷酸和硼酸的钠盐、钾盐和铵(R1R2R3)盐，R1、R2和R3如前述定义；羟乙磺酸；鞣酸；和该制剂的酰胺。
其中
R1为氢或C1-C12烷基
R2和R3分别独立地为氢、C1-C12烷基、C2-C12链烯基、C1-C12羟基链烯基、C2-C12羟基烷基；或具有1-30个-CH2-CH2-O-或-CHY1-CHY2-O-基团的聚乙二醇醚链，其中Y1或Y2中一个为氢基，另一个为甲基，如N-甲基-乙酰胺。
所有应用在本发明中的与成分(b3)相关的羧酸也优选以其水溶性碱金属盐或铵盐的形式应用。
根据本发明优选液体制剂(a)含有；
(a1)20-70％，优选30-60％(重量)的式(1)的杀微生物活性成分和
(a2)30-80％，优选40-70％(重量)的一元-或二元醇或其混合物，
最特别优选制剂中含有作为成分(a2)的式(9)化合物如一元醇和/或在烷基部分有2-6个碳原子的二元醇。
根据上述优选应用的制剂应为含有一元醇或二元醇的制剂。特别是，适当的一元醇为苯氧乙醇，适当的二元醇为1，2-丙二醇。
优选液体制剂(b)含有
(b1)10-30％，优选15-25％(重量)的式(1)杀微生物活性成分，
(b2)0-80％，优选10-70％(重量)的磺酸盐
(b3)1-60％，优选10-50％(重量)的C1-C11单羧酸或C3-C12双-或多羧酸；和
(b4)0-90％，优选5-75％(重量)的一元-或二元醇，
和水加至100％。
存在一种(b2)或(b4)成分总是必要的。
最特别优选的液体制剂(b)为这样的制剂，其包括作为成分(b2)的异丙基苯磺酸盐，作为成分(b3)的醇酸和作为成分(b4)的在烷基部分有2-6个碳原子的二元醇。
主要优选液体制剂(b)含有
(b1)105-25％(重量)的式(1)杀微生物活性成分，
(b2)10-70％(重量)的异丙基苯磺酸盐
(b3)10-50％(重量)的乳酸；
(b4)5-75％(重量)的1，2-丙二醇，和
水加至100％。
根据本发明的液体制剂可以用作化妆品例如除味剂、清洗剂、洗剂/乳剂的活性成分，用作家居用品例如作为洗涤液、液体家居清洁剂的活性成分；用作牙齿护理用品例如在漱口液或牙膏中用作添加剂，或作为硬和软表面例如聚合物、纸张、织物特别是人的皮肤的杀微生物活性成分。
根据本发明的液体制剂也可以进一步适合作为化妆品和家居用品的防腐剂。
它们也可以用作织物纤维物质的消毒剂。
可以通过下列方法制备根据本发明的液体制剂：将成分(a1)或(b1)溶于成分(a2)或(b4)中，在搅拌下向产生的溶液中加入(b2)或(b3)，用去离子水补足产生的溶液至终体积的90-95％，如果适当，用化妆品可接受的碱例如一或二乙醇胺调节pH，用去离子水补足至终体积的100％。
以不引起麻烦的方式将溶解的杀微生物活性成分掺入到化妆品和家居用品中。以溶解的形式给使用者提供其本身为粉末状的活性成分。在供应时，费时的在适当的溶剂中的预溶解过程不再需要加热。
而且，根据本发明的液体制剂具有显著的协同杀微生物作用(见实施例15)和良好的储存稳定性。
下列实施例说明根据本发明的液体制剂的制备。部分为重量部分。
浓缩液体制剂的制备实施例
实施例1
将60份的式(101)的化合物加至容器中
加入40份1，2-丙二醇，在一定的介质中于50-60℃搅拌该混合物至式(101)化合物完全溶解
实施例2
将30份的式(101)的化合物加至容器中
加入70份2-苯氧基乙醇，在一定的介质中于50-60℃搅拌该混合物至式(101)化合物完全溶解
实施例3
将6份式(101)化合物和
20份1，2-丙二醇称于容器中，在一定的介质中于50-60℃搅拌该混合物至形成澄清溶液。然后，
将30份柠檬酸，
35份二甲苯磺酸钠和
4份去离子水按上述顺序加入，继续搅拌至所有的成分溶解。加入乙醇胺调节混合物的pH为3-4，该混合物用去离子水补足至100份。
实施例4
将15份式(101)化合物和
10份乙醇称于容器中，于室温下搅拌该混合物至形成澄清溶液。然后，
将35份十一碳烯酸，
20份二甲苯磺酸钠和
10份去离子水按上述顺序加入，继续搅拌至所有的成分溶解。加入乙醇胺调节混合物的pH为3-4，该混合物用去离子水补足至100份。
实施例5
将10份式(101)化合物和
5份1，2-丙二醇称于容器中，于室温下搅拌该混合物。
加入30份酒石酸。加入乙醇胺调节混合物的pH为3-4。
将30份异丙基苯磺酸钠和
10份去离子水按上述顺序加入，继续搅拌至所有的成分溶解。该混合物用去离子水补足至100份。
实施例6
将10份式(101)化合物和
5份1，2-丙二醇称于容器中，于室温下搅拌。
加入40份乳酸。加入乙醇胺调节混合物的pH为3-4。
将30份异丙基苯磺酸钠和
10份去离子水按上述顺序加入，继续搅拌至所有的成分溶解。该混合物用去离子水补足至100份。
实施例7
将10份式(101)化合物和
10份1，3-丁二醇称于容器中，于室温下搅拌至形成澄清溶液。然后
将30份酒石酸，
30份异丙基苯磺酸钠和
10份去离子水按上述顺序加入，继续搅拌至所有的成分溶解。加入乙醇胺调节混合物的pH为3-4。该混合物用去离子水补足至100份。
实施例8-13：使用另外的杀微生物活性成分的其它液体制剂
实施例8
将10份苄醇和
5份丙二醇称于容器中，于室温下搅拌。然后
将40份乳酸，
30份异丙基苯磺酸钠和
10份去离子水按上述顺序加入，继续搅拌至所有的成分溶解。加入一乙醇胺调节混合物的pH为5.5，该混合物用去离子水补足至100份。
实施例9
将10份2，4-二氯苄醇和
5份丙二醇称于容器中，于室温下搅拌至形成澄清溶液。然后
将40份乳酸，
30份异丙基苯磺酸钠和
10份去离子水按上述顺序加入，继续搅拌至所有的成分溶解。加入一乙醇胺调节混合物的pH为5.5，该混合物用去离子水补足至100份。
实施例10
将10份对-氯-间二甲苯酚，
5份丙二醇和
30份异丙基苯磺酸钠称于容器中，于室温下搅拌至形成澄清溶液。然后
将40份乳酸和
10份去离子水按上述顺序加入，继续搅拌至所有的成分溶解。加入乙醇胺调节混合物的pH为5.5，该混合物用去离子水补足至100份。
实施例11
将10份邻-苯基苯酚和
5份丙二醇称于容器中，在一定的介质中，于50-60℃搅拌至形成澄清溶液。然后
将40份乳酸，
30份异丙基苯磺酸钠和
10份去离子水按上述顺序加入，继续搅拌至所有的成分溶解。加入一乙醇胺调节混合物的pH为5.5，该混合物用去离子水补足至100份。
实施例12
将10份对-氯-间-甲酚和
5份丙二醇称于容器中，在一定的介质中，于50-60℃搅拌至形成澄清溶液。然后
将40份乳酸，
30份异丙基苯磺酸钠和
10份去离子水按上述顺序加入，继续搅拌至所有的成分溶解。加入一乙醇胺调节混合物的pH为5.5，该混合物用去离子水补足至100份。
实施例13
将10份苯扎氯铵和
5份丙二醇称于容器中，于室温下搅拌至形成澄清溶液。然后
将40份乳酸，
30份异丙基苯磺酸钠和
10份去离子水按上述顺序加入，继续搅拌至所有的成分溶解。加入一乙醇胺调节混合物的pH为5.5，该混合物用去离子水补足至100份。
实施例14：在悬浮液实验中检测杀微生物活性
实验           金黄色酿脓葡萄球菌ATCC9144
微生物         粪肠球菌ATCC10541
               大肠杆菌ATCC10536
               绿脓假单胞菌CIP A-22
               白色念珠菌ATCC10231
营养培养基     生长接种物的酪蛋白大豆粉蛋白胨肉汤
               含有10％聚氧乙烯(20)山梨醇单油酸酯；0.3％卵
               磷脂；0.1％L-组氨酸的酪蛋白大豆粉蛋白胨琼脂
稀释培养基     含有10％聚氧乙烯(20)山梨醇单油酸酯；0.3％卵
               磷脂；0.1％L-组氨酸和0.5％硫代硫酸钠的
               胰蛋白酶解酪蛋白大豆粉蛋白胨肉汤
a.实施例6的制剂作为消毒剂的应用
这些实验表明根据本发明的液体制剂即使在低浓度下也具有非常强的杀微生物活性。这些性质对于一般的消毒剂是重要的，但特别是对于织物的消毒。
方法：
用8.9ml水稀释0.1ml实施例6的制剂，然后用1ml试验细菌培养液的1∶10稀释液处理上述稀释液，于37℃孵育16-24小时(＝1％的实施例6的制剂)。每批中试验微生物的浓度为108个微生物/ml。将每批完全混合，然后在轻轻搅拌下于室温孵育5分钟。
5分钟后，从每批中取出1ml，对活菌计数。最后，在稀释培养基中进行稀释，取这些稀释液的0.1ml置于琼脂培养基上。
于37℃将培养板孵育24-48小时后，通过计数菌落(考虑稀释因素)测定活细菌数。
实验结果列于表1。
  表1
  批     5分钟后细菌计数的减少(log)
金黄色酿脓葡萄球菌ATCC9144 粪肠球菌ATCC10541 大肠杆菌ATCC10536 绿脓假单胞菌CIP A-22
  水 0  0  0  0
  1％制剂6 ＞105 ＞105 ＞105 ＞105
对实施例6的制剂的实验表明：在悬浮液实验中，在5分钟后，试验微生物至少降低105。
b.含有2，4，4’-三氯-2’-羟基二苯基醚的浓缩制剂液体皂
对实施例14b和14c的实验表明：加入了根据本发明的液体制剂的皂制剂具有强的杀微生物活性，该活性不仅为作为手消毒或净化剂使用是必须的，而且对表面的杀微生物处理(表面消毒剂、抗微生物洗碗用品和家居清洗剂等)也是必须的。
试验组成：
4％十二烷基硫酸钠
10％实施例6的制剂
水加至100％
用乙醇胺将pH调至5.5。
方法：
将9ml该制剂与1ml 1∶10稀释的于37℃孵育16-24小时的细菌悬浮液混合，然后在搅拌下将该混合物于室温下孵育。
孵育30秒后，从试验批中取出1ml，用稀释培养基稀释，取0.1ml稀释液置于琼脂培养基上。
将培养板于37℃孵育24-48小时后，通过计数菌落(考虑稀释因素)测定活细菌数。
实验结果列于表2。
表2：
试验微生物                       30秒后试验微生物的降低(Log)
金黄色酿脓葡萄球菌ATCC9144                   ＞5
粪肠球菌ATCC10541                            ＞5
大肠杆菌ATCC10536                            ＞5
绿脓假单胞菌CIP A-22                         ＞5
S.marcescens ATCC13880                       2.2
白色念珠菌ATCC10231                          2.4
该液体皂对试验微生物显示非常强的杀微生物活性。
c.含有浓缩制剂的液体皂
实验组成：
对下列组成的皂进行实验：
4％十二烷基硫酸钠
10％实施例9-14的浓缩制剂
水加至100％
用一乙醇胺将pH调至5.5。
方法：
将9ml该制剂与1ml 1∶10稀释的于37℃孵育16-24小时的细菌悬浮液混合，然后在搅拌下将该混合物于室温下孵育。
孵育1分钟后，从试验批中取出1ml，用稀释培养基稀释，取0.1ml稀释液置于琼脂培养基上。
将培养板于37℃孵育24-48小时后，通过计数菌落(考虑稀释因素)测定活细菌数。
实验结果列于表3。
表3：
浓制剂的试验皂的实例           1分钟后试验微生物的减少(Log)
                               绿脓假单胞菌CIP A-22
9                                         ＞5
10                                        ＞5
11                                        ＞5
12                                        ＞5
13                                        ＞5
14                                        ＞5
安慰剂                                    0.9
所有试验制剂显示强的杀微生物活性。
实施例15：液体皂的防腐压力实验
重复防腐压力实验(三倍压力)证明浓缩物非常适于化妆品和家居用品的防腐。
皂组成：
6％laureth-2硫酸钠
水加至100％
用一乙醇胺将pH调至5.5。
用下列浓缩组成的皂制剂防腐：
A：3％的实施例7的制剂
B：1％的实施例2的制剂
实验微生物          金黄色酿脓葡萄球菌ATCC9144
                    大肠杆菌ATCC10536
                    日勾雄肠杆菌ATCC33038
                    产酸克雷伯氏菌DSM30106
                    绿脓假单胞菌CIP A-22
                    荧光假单孢菌ATCC17397
                    白色念珠菌ATCC10231
                    黑曲菌ATCC6275
营养培养基          含有3％聚氧乙烯(20)山梨醇单油酸酯；0.3％卵
                    磷脂；0.1％L-组氨酸的酪蛋白大豆粉蛋白胨琼脂
稀释培养基          含有10％聚氧乙烯(20)山梨醇单油酸酯；0.3％卵
                    磷脂；0.1％L-组氨酸和0.5％硫代硫酸钠的
                    胰蛋白酶解酪蛋白大豆粉蛋白胨肉汤
用0.2ml微生物悬浮液接种20g试验皂制剂，使产生的产物的微生物压力为105-106个微生物/g产物。
为及时测定特定点的总微生物计数，取出1g物质，用稀释培养基确立稀释系列。将0.1ml稀释液置于琼脂培养基上，于37℃孵育24小时后(细菌和酵母菌)或于28℃孵育5天后(曲霉菌)，进行总微生物计数测定。
于接种和1和2周后，测定产物中总细菌计数。2和4周后，用试验微生物以相同的方式对产物进行再一次接种，在每一种情况下再过1和2周后测定总微生物计数。
实验结果列于表4：
表4：
试验微生物                            防腐
                                      A       B      未防腐
金黄色酿脓葡萄球菌ATCC9144       +/+/+     +/+/+    -/-/-
大肠杆菌ATCC 10536               +/+/+     +/+/+    -/-/-
日勾雄肠杆菌ATCC 33038           +/+/+     +/+/+    -/-/-
绿脓假单胞菌CIP A-22             +/+/+     +/+/+    -/-/-
荧光假单孢菌ATCC 17397           +/+/+     +/+/+    -/-/-
白色念珠菌ATCC 10231             +/+/+     +/+/+    -/-/-
黑曲菌ATCC 6275                  +/+/+     +/+/+    -/-/-
+＝接种后2周内总细菌计数至少降低99％。
-＝接种后2周内总微生物计数降低少于99％。
实施例16：合成洗涤剂的制备(清洁剂制剂)
15.7％烷基芳基磺酸盐
3.7％脂肪醇磺酸盐
2.7％脂肪酸一乙醇酰胺
39％三聚磷酸酯
4％硅酸钠
2％硅酸镁
1％羧甲基纤维素
0.5％EDTA
2％实施例2的制剂
4.7％水
制备：
将所述成分与等量的水搅拌为淤浆。于50℃干燥产生的糊状物，最后通过0.8mm目直径的筛。弃去＜0.3mm的颗粒。
实施例17：洗碗剂产品的制备
7％十二烷基硫酸钠
7％myreth硫酸钠
4％十二烷基葡萄糖苷
1％cocamidopropylbetaine
1％实施例6的制剂
1％氯化钠
0.02％二溴代二氰基丁烷
0.08％苯氧基乙醇
78.9％水
制备：
将十二烷基硫酸钠与myreth硫酸钠和十二烷基葡萄糖苷混合并溶于30份水中。加入实施例6的制剂并匀化。加入cocamidopropylbetaine、氯化钠、二溴代二氰基丁烷和苯氧基乙醇。用柠檬酸将pH调至6.0。加入水至100份。
实施例18：织物消毒剂的制备：
50％实施例6的制剂
10％十二烷醇乙二醇醚
水加至100％
用一乙醇胺将pH调至5
实施例19：手消毒剂的制备
4％
0.5％羟乙基纤维素
3％实施例2的制剂
水加至100％
制备：
将十二烷基硫酸钠溶于20份水中，加入实施例2的制剂。于60℃将羟乙基纤维素溶于60份水中，冷却并加至表面活性剂混合物中。用一乙醇胺将pH调至5.5。加入水至100份。
实施例20：手消毒剂的制备
4％十二烷基硫酸钠
0.5％羟乙基纤维素
3％实施例7的制剂
水加至100％
用一乙醇胺将pH调至5.5。
制备：
将十二烷基硫酸钠溶于20份水中，加入实施例2的制剂。于60℃将羟乙基纤维素溶于60份水中，冷却并加至表面活性剂混合物中。用一乙醇胺将pH调至5.5。加入水至100份。
实施例21：浴液凝胶的制备
6％laureth-2硫酸钠
3％cocamidopropylbetaine
1.5％水解蛋白
1.5％laureth-9
0.3％polyquaternium-7
1％实施例2的液体制剂
1.0％甘油二硬脂酸酯
0.2％氯化钠
水加至100％
制备：
于50℃将甘油二硬脂酸酯溶于laureth-2硫酸钠中。将其余的成分和30份水连续加入并均化。
用一乙醇胺将pH调至5.5并加入水至100份。
也可能使用0.5-1.5％的实施例1的制剂或1-10％的实施例3-12的制剂代替1％的实施例2的制剂。

Claims (8)

1.浓缩液体制剂(a)，含有
(a1)20-70％重量的杀微生物活性成分，该活性成分选自下式的2-羟基二苯基醚
Figure C9719509900021
其中
Y为氯或溴，
Z为SO2H、NO2或C1-C4烷基，
r为1或2，
o为1或2，
p为0，
m为0，和
n为0或1；和
(a2)30-70％重量的通式如下的醇：其中
X为卤素原子，
Y为式-O-CH2-或-CH2-基团或直接为键；和
n为0或1-5的整数，或者
在烷基部分中具有2-6个碳原子的二元醇。
2.权利要求1的液体制剂，其中成分a1具有下式
3.权利要求1或2的液体制剂在化妆品中作为杀微生物活性成分的用途。
4.权利要求1或2的液体制剂在居家用品中作为杀微生物活性成分的用途。
5.权利要求1或2的液体制剂用作硬表面和软表面杀微生物活性成分的非治疗用途。
6.权利要求5的用途，其中所述液体制剂用于人的皮肤。
7.权利要求1或2的液体制剂在化妆品和居家用品中作为防腐剂的用途。
8.权利要求1或2的液体制剂用作织物消毒剂的用途。
9.权利要求1或2的液体制剂用作皮肤和硬表面净化剂或消毒剂的用途。
CNB971950997A 1996-06-04 1997-05-22 含有杀微生物的活性成分的浓缩液体制剂 Expired - Fee Related CN1133418C (zh)

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ID17019A (id) 1997-12-04
WO1997046218A2 (en) 1997-12-11
ES2375350T3 (es) 2012-02-29
DE69715421D1 (de) 2002-10-17
AU2959497A (en) 1998-01-05
EP0914085B1 (en) 2002-09-11
MY126299A (en) 2006-09-29
ZA974871B (en) 1998-05-20
WO1997046218A3 (en) 1998-03-12
JP4106091B2 (ja) 2008-06-25
TW464491B (en) 2001-11-21
CO4850630A1 (es) 1999-10-26
EP1201229A1 (en) 2002-05-02
EP1201229B1 (en) 2011-11-09
EP0914085A2 (en) 1999-05-12
AR008760A1 (es) 2000-02-23
US6358906B1 (en) 2002-03-19

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