CN113155941A - Data acquisition system based on ion mobility spectrometry - Google Patents
Data acquisition system based on ion mobility spectrometry Download PDFInfo
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- CN113155941A CN113155941A CN202110300631.5A CN202110300631A CN113155941A CN 113155941 A CN113155941 A CN 113155941A CN 202110300631 A CN202110300631 A CN 202110300631A CN 113155941 A CN113155941 A CN 113155941A
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- 238000001871 ion mobility spectroscopy Methods 0.000 title claims abstract description 23
- 238000000034 method Methods 0.000 claims abstract description 7
- 238000004891 communication Methods 0.000 claims abstract description 6
- 239000000126 substance Substances 0.000 claims description 12
- 238000001514 detection method Methods 0.000 claims description 7
- 238000005259 measurement Methods 0.000 claims description 4
- 238000001228 spectrum Methods 0.000 claims description 4
- 230000007613 environmental effect Effects 0.000 claims description 2
- 238000011160 research Methods 0.000 abstract description 6
- 238000010276 construction Methods 0.000 abstract description 2
- 238000013500 data storage Methods 0.000 abstract description 2
- 150000002500 ions Chemical class 0.000 description 8
- 238000012545 processing Methods 0.000 description 5
- 230000000694 effects Effects 0.000 description 3
- 238000012935 Averaging Methods 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- 238000004587 chromatography analysis Methods 0.000 description 2
- 238000007405 data analysis Methods 0.000 description 2
- 238000005070 sampling Methods 0.000 description 2
- 230000035945 sensitivity Effects 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000012159 carrier gas Substances 0.000 description 1
- 239000002575 chemical warfare agent Substances 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003344 environmental pollutant Substances 0.000 description 1
- 239000002360 explosive Substances 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/62—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating the ionisation of gases, e.g. aerosols; by investigating electric discharges, e.g. emission of cathode
- G01N27/622—Ion mobility spectrometry
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Abstract
The invention discloses a data acquisition system based on ion mobility spectrometry, which comprises a USB data acquisition card, an stm32 single chip microcomputer and PC upper computer software, wherein the data acquisition system based on ion mobility spectrometry acquires acquired data in real time through NI high-precision acquisition equipment, simultaneously performs environment control and necessary parameter acquisition on a lower computer through serial communication with the single chip microcomputer, the upper computer is connected with the data acquisition card through a USB channel and simultaneously provides power supply, controls instrument parameters in real time through serial communication, and performs security control on the instrument according to temperature parameters. The invention is more flexible, the acquisition and storage of spectrogram data are more convenient through the construction and use of the database, and the method is more suitable for scientific research personnel to analyze, so that the safety and the flexibility of the database are combined with the ion mobility spectrometry, the data storage is safer, and the scientific research personnel can look up the data more conveniently.
Description
Technical Field
The invention belongs to the technical field of detection, and particularly relates to a data acquisition system based on ion mobility spectrometry.
Background
Ion mobility spectrometry was a detection technique developed from the end of the 60's 20 th century and it was originally called plasma chromatography by a concept similar to the retention time of chromatography, with the difference in ion mobility time to characterize the separation of ions. The ion mobility spectrometry has the advantages of high sensitivity, high detection speed, low power consumption, small volume, adaptability to atmospheric pressure and room temperature working environment and the like, and is widely applied to the rapid detection of drugs, explosives, chemical warfare agents and environmental pollutants. The proper working temperature, humidity and carrier gas flow rate can effectively improve the generation rate and the utilization rate of ions, and improve the analysis accuracy and the analysis efficiency of the ion mobility spectrometer to a certain extent, thereby improving the detection sensitivity and the selectivity of the instrument. However, most of the current ion mobility spectrums cannot independently realize precise position control on the ion mobility spectrums, so that the problems of inconvenient operation, difficult miniaturization and the like exist.
Disclosure of Invention
In order to solve the problems in the prior art, the invention provides a data acquisition system based on ion mobility spectrometry. The technical problem to be solved by the invention is realized by the following technical scheme: the invention provides a data acquisition system based on ion mobility spectrometry, which comprises a USB data acquisition card, an stm32 single chip microcomputer and PC upper computer software, wherein the data acquisition system acquires acquired data in real time through NI high-precision acquisition equipment, environmental control and necessary parameter acquisition are carried out on a lower computer through serial communication with the stm32 single chip microcomputer, the PC upper computer software is connected with the USB data acquisition card through an SB channel and simultaneously supplies power, instrument parameters are controlled in real time through serial communication, and safety control is carried out on an instrument according to temperature parameters.
In one embodiment of the invention, the PC upper computer software is written by C # based on a net platform.
In one embodiment of the present invention, there are five functions, including:
(1) setting parameters: setting parameters of a lower computer and related instruments of the acquisition card through serial port connection;
(2) spectrogram mode: after parameter setting is completed, acquiring spectrogram data of the ion mobility spectrometry by using a data acquisition card, and storing the data into a MySQL database by using a storage function;
(3) standard library schema: storing the standard substance strength measurement in a MySQL database through preset standard substance strength measurement, and synchronizing data in the MySQL database by modifying the data in the mode;
(4) list mode: obtaining a spectrum peak by a symmetrical zero-area peak searching method, calculating the intensity according to the peak area, and identifying the current substance according to the intensity in a standard library;
(5) history recording: and storing the previously acquired spectrogram information and substance detection information.
Compared with the prior art, the invention has the beneficial effects that:
compared with traditional ion mobility spectrometry upper computer software, the method is more flexible, spectrogram data can be acquired and stored more conveniently by building and using the database, and the method is more suitable for scientific research personnel to analyze, so that the safety, flexibility and ion mobility spectrometry of the database are combined, data storage is safer, and the scientific research personnel can look up the data more conveniently. In the aspect of data processing, a symmetrical zero-area peak searching method most suitable for ion mobility spectrometry is selected, so that data analysis is more accurate.
The present invention will be described in further detail with reference to the accompanying drawings and examples.
Drawings
FIG. 1 is a block diagram of an embodiment of the present invention.
FIG. 2 is a flow chart of spectrogram acquisition in the present invention.
FIG. 3 is a flow chart of spectrogram processing in the present invention.
Fig. 4 is a flow chart of data display in the present invention.
Detailed Description
To further explain the technical means and effects of the present invention adopted to achieve the predetermined objects, a detailed description is provided below with reference to the accompanying drawings and the detailed description.
The foregoing and other technical matters, features and effects of the present invention will be apparent from the following detailed description of the embodiments, which is to be read in connection with the accompanying drawings. The technical means and effects of the present invention adopted to achieve the predetermined purpose can be more deeply and specifically understood through the description of the specific embodiments, however, the attached drawings are provided for reference and description only and are not used for limiting the technical scheme of the present invention.
It is noted that, herein, relational terms such as first and second, and the like may be used solely to distinguish one entity or action from another entity or action without necessarily requiring or implying any actual such relationship or order between such entities or actions. Also, the terms "comprises," "comprising," or any other variation thereof, are intended to cover a non-exclusive inclusion, such that an article or apparatus that comprises a list of elements does not include only those elements but may include other elements not expressly listed. Without further limitation, an element defined by the phrase "comprising an … …" does not exclude the presence of additional identical elements in the article or device comprising the element.
Examples
FIG. 1 shows the connection of a data acquisition system according to the present invention to an ion mobility spectrometer. As shown in figure 1, the whole device consists of an ion mobility spectrometer basic assembly, a data acquisition card, a single chip microcomputer and a PC upper computer, wherein the data acquisition card is connected with the PC through a USB connecting line and is also connected with an instrument to acquire data in real time, the single chip microcomputer is connected with a control part of the instrument, and the other end of the single chip microcomputer is connected with the PC through an RS 232-USB end.
The spectrogram acquisition shown in fig. 2 comprises the following steps:
2.1 parameter setting: filling corresponding control parameters in a parameter setting system or controlling the acquisition card and the single chip microcomputer part by using default settings, if the numerical values are not specified, inputting the data and inputting the data again, and after the setting is finished, executing the step 2.2;
2.2, data acquisition: opening a spectrogram mode, starting clicking, establishing an analog channel, and continuously acquiring data by the acquisition card according to the setting of the step A to perform sampling averaging and write the data into a cache region
2.3, storage: reading the data in the cache region, opening database connection, setting every 1400 points as a group according to the standard of a spectrogram, and storing the group in the MySQL database;
2.4 stop collection and shut down: and closing the connection of the database, suspending acquisition of the acquisition card and closing the channel, cutting off the connection of the system with the single chip microcomputer and the acquisition card, and entering a dormant state.
The spectrogram processing shown in fig. 3 comprises the following steps:
3.1 setting parameters: filling corresponding control parameters in a parameter setting system or controlling the acquisition card and the single chip microcomputer part by using default settings, if the numerical values are not specified, inputting the data and inputting the data again, and after the setting is finished, executing the step 3.2;
3.2, data acquisition: opening a spectrogram mode, starting clicking, establishing an analog channel, and continuously acquiring data by the acquisition card according to the setting of the step A to perform sampling averaging and write the data into a cache region;
3.3 data processing: calculating a peak value of spectrogram data by convolution of a Gaussian function and the data according to a preset algorithm by the system for reading the data of the cache region, and calculating intensity according to a peak area corresponding to the peak value;
3.4 data comparison: opening the connection with the database, acquiring the data of the standard library and storing the data in a buffer area, comparing the result of the step C with the data in the buffer area, wherein the error is within 0.1, if the result is the substance, the result is displayed as the unknown substance, and if the result is not the substance, the result is displayed as the unknown substance;
3.5 storing the results: storing the result of the step 3.4 and the corresponding data into a database as a use log;
3.6 stop collection and shut down: and closing the connection of the database, suspending acquisition of the acquisition card and closing the channel, cutting off the connection of the system with the single chip microcomputer and the acquisition card, and entering a dormant state.
The historical data acquisition as shown in fig. 4 comprises the following steps:
4.1, data acquisition, namely connecting a database to acquire required data and storing the required data in a cache region;
4.2 data show: and the upper computer screens in the cache area according to different data retrieval conditions, converts the result into spectrogram data and displays the result.
4.3 closing: and closing the database connection by the upper computer, emptying the cache region and closing the system.
Compared with the traditional ion mobility spectrometry upper computer software, the ion mobility spectrometry upper computer software is more flexible, spectrogram data can be acquired and stored more conveniently through the construction and use of the database, and the ion mobility spectrometry upper computer software is also more suitable for scientific research personnel to analyze, so that the safety and flexibility of the database are combined with the ion mobility spectrometry, the data is stored more safely, and the scientific research personnel can look up the data more conveniently. In the aspect of data processing, a symmetrical zero-area peak searching method most suitable for ion mobility spectrometry is selected, so that data analysis is more accurate.
The foregoing is a more detailed description of the invention in connection with specific preferred embodiments and it is not intended that the invention be limited to these specific details. For those skilled in the art to which the invention pertains, several simple deductions or substitutions may be made without departing from the spirit of the invention, which should be construed as belonging to the scope of the invention.
Claims (3)
1. The utility model provides a data acquisition system based on ion mobility spectrometry, its characterized in that, includes USB data acquisition card, stm32 singlechip and PC host computer software, wherein, data acquisition system obtains the data of gathering in real time through the high accuracy collection equipment of NI, simultaneously through with carry out serial communication between the stm32 singlechip and carry out environmental control and necessary parameter acquisition to the next computer, PC host computer software passes through the USB passageway with USB data acquisition card is connected and provides the power supply simultaneously, through serial communication real-time control instrument parameter, carries out the security management and control to the instrument according to the temperature parameter.
2. The ion mobility spectrometry-based data acquisition system of claim 1, wherein the PC host computer software is written by C # based on a.net platform.
3. The ion mobility spectrometry-based data acquisition system of claim 1, wherein the system has five functions, including:
(1) setting parameters: setting parameters of a lower computer and related instruments of the acquisition card through serial port connection;
(2) spectrogram mode: after parameter setting is completed, acquiring spectrogram data of the ion mobility spectrometry by the USB data acquisition card, and storing the data into a MySQL database by a storage function;
(3) standard library schema: storing the standard substance strength measurement in a MySQL database through preset standard substance strength measurement, and synchronizing data in the MySQL database by modifying the data in the mode;
(4) list mode: obtaining a spectrum peak by a symmetrical zero-area peak searching method, calculating the intensity according to the peak area, and identifying the current substance according to the intensity in a standard library;
(5) history recording: and storing the previously acquired spectrogram information and substance detection information.
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| CN202110300631.5A CN113155941A (en) | 2021-03-22 | 2021-03-22 | Data acquisition system based on ion mobility spectrometry |
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| CN102854237A (en) * | 2011-06-30 | 2013-01-02 | 李德和 | On-site intelligent fast real-time detector of residue of beta-adrenalin receptor agonist adopting ion mobility spectrometry |
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2021
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Patent Citations (9)
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|---|---|---|---|---|
| CN101918583A (en) * | 2007-10-19 | 2010-12-15 | 查尔斯斯塔克德雷珀实验室公司 | Rapid detection of volatile organic compounds for identification of bacteria in a sample |
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| CN102854237A (en) * | 2011-06-30 | 2013-01-02 | 李德和 | On-site intelligent fast real-time detector of residue of beta-adrenalin receptor agonist adopting ion mobility spectrometry |
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