CN113144141A

CN113144141A - A Chinese medicinal composition for treating cough

Info

Publication number: CN113144141A
Application number: CN202110439755.1A
Authority: CN
Inventors: 陈杰勇; 窦勇进; 苑丽双; 李晨龙
Original assignee: Individual
Current assignee: Individual
Priority date: 2021-04-23
Filing date: 2021-04-23
Publication date: 2021-07-23

Abstract

The invention belongs to the technical field of Chinese patent medicines, and particularly discloses a traditional Chinese medicine composition for treating cough. The medicine is prepared from platycodon grandiflorum, almond, radix curcumae, radix ophiopogonis, radix asparagi and liquorice, is prepared into medicinal powder with the grade of at least 600 meshes by using superfine grinding equipment, and is prepared into powder, pills or other formulations. The traditional Chinese medicine composition can be applied to cough of people as young as 3 years old and as old as 75 years old, has excellent treatment effect, adopts common medicinal materials as the components, and has the characteristics of easy acquisition and simple processing procedure.

Description

A Chinese medicinal composition for treating cough

Technical Field

The invention belongs to the technical field of Chinese patent medicines, and particularly relates to a traditional Chinese medicine composition for treating cough.

Background

Cough (cough) is a common respiratory symptom. The trachea, the bronchial mucosa or the pleura are caused by inflammation, foreign bodies, physical or chemical stimulation. Cough has a protective function of removing foreign matters and secretions of the respiratory tract, but if the cough is ceaselessly or is converted from acute to chronic, great pain is often brought to patients, such as chest distress, throat itching, wheezing and the like, the cough can be accompanied with expectoration, sometimes the cough symptom is not cured for a long time, and the life quality of the patients is seriously influenced. Chronic cough is a common disease with prevalence rates as high as 12%. At present, the common medicaments for treating cough comprise traditional Chinese medicines and western medicines, and the western medicines comprise central antitussives such as: codeine, peripheral antitussives such as: narcotine and the like, and due to the toxicity and adverse reactions of western medicines, and a plurality of antitussives lack exact antitussive effect, or have adverse reactions which are difficult to be tolerated by patients, even have addiction, so the application of narcotine and the like is limited; in addition, expectorants are added for cough with more sputum, and the application of various medicines can aggravate side effects and anaphylactic reaction; the traditional Chinese medicine for treating cough has the advantages of mutual balance of the medicines, attenuation and synergism, and low toxicity as a whole. Such as

The invention patent application with the Chinese patent application number of 201811530412.0 and the application publication number of CN109453298A discloses a traditional Chinese medicine preparation for treating cough after cold, which is prepared from 20 traditional Chinese medicines such as radix peucedani, platycodon grandiflorum, almond, aster, loquat leaf, dried orange peel, poria cocos, cassia twig and the like through the steps of heating, sterilizing, crushing by a crusher, sieving by a 100-mesh sieve, and drying, wherein the mass ratio of the traditional Chinese medicines is 1: 1 adding refined honey to prepare large honeyed pills, and has the effects of warming lung and relieving cough, invigorating spleen and replenishing qi, moistening lung and nourishing yin, promoting fluid production and reducing phlegm, clearing heat and detoxicating, lifting yang qi and the like. However, the traditional Chinese medicine preparation not only comprises a plurality of medicinal material components, the components are complex, and the proper patients can be selected for correct application by higher professional knowledge, but also has the advantages of lung warming, cough relieving and overall preference to heat, so the traditional Chinese medicine preparation is not suitable for excessive heat cough, and the schisandra chinensis contained in the formula is not suitable for the treatment of the exterior evil, the internal excessive heat, the early cough and the like, so the door closing and the upper limit are easy to be caused, and the deformation is caused.

The invention patent application with Chinese patent application number of 201811270944.5 and application publication number of CN108992563A discloses a Wuzi cough syrup for treating cough after cold, which contains 14 traditional Chinese medicines, wherein crystal sugar is not suitable for diabetes patients, and the prescription contains schisandra chinensis which is not suitable for the treatment of exterior evil, interior excess heat, cough initial stage and the like, thus easily causing door closing and leaving a nutmeg to generate distortion.

The invention patent application with Chinese patent application No. 20110111681.5 and application publication No. CN10276437A discloses strong loquat syrup for treating cough, which consists of six traditional Chinese medicines and a chemical agent menthol, wherein the chemical agent menthol is toxic and is forbidden for infants, and poppy shell contained in the syrup is toxic and easy to addiction and is not suitable for large-scale or long-term administration.

Disclosure of Invention

The invention aims to provide a pure traditional Chinese medicine composition for treating cough, which has the advantages of wide range of applicable patients, refined medicinal taste, delicate formula, good curative effect, simple preparation process and prominent traditional Chinese medicine characteristics.

The technical scheme for realizing the purpose of the invention is as follows:

a traditional Chinese medicine composition for treating cough comprises the following components in parts by weight:

10 parts of platycodon grandiflorum, 3-9 parts of almond, 3-9 parts of radix curcumae, 3-9 parts of radix ophiopogonis, 1-6 parts of radix asparagi and 1-6 parts of liquorice.

The preparation method of the traditional Chinese medicine composition comprises the following steps:

the medicines are prepared by mixing the medicine components, preparing the medicine powder with a grade of at least 600 meshes by using superfine grinding equipment, and then preparing the medicine powder into pills, powder or other formulations.

Wherein, the preparation process flow of the watered pill is as follows: material preparation → mold drawing → general molding → capping → drying → pill selection → coating → polishing → quality inspection → packaging.

The medicinal properties and pharmacological actions of the selected Chinese herbal medicine components in the Chinese herbal medicine composition for treating the cough are as follows:

balloon flower: bitter, pungent and mild. It enters lung meridian. Disperse lung qi, relieve sore throat, dispel phlegm, and expel pus. Can be used for treating cough with excessive phlegm, chest distress, pharyngalgia, hoarseness, lung carbuncle, suppuration, and pyocutaneous disease with pus formation. The modern pharmacological research has the advantages of strong phlegm eliminating effect and good cough relieving effect, and the compatible compound has the effects of relieving asthma, resisting bacteria and inflammation and enhancing immunity.

Almond: bitter, slightly warm and slightly toxic. It enters lung and large intestine meridians. Direct qi downward to relieve cough and dyspnea, moisten intestines to relieve constipation. Can be used for treating cough, asthma, chest distress, excessive phlegm, and constipation due to intestinal dryness. The modern pharmacological research has the effects of relieving cough and asthma, resisting inflammation, relieving pain, enhancing the cellular immunity of organisms, resisting peptic ulcer, resisting tumor, resisting cerebral ischemia and reducing blood sugar.

Turmeric root-tuber: promoting blood circulation to arrest pain, promoting qi circulation to relieve depression, clearing away heart-fire, cooling blood, promoting bile flow, and eliminating jaundice. Can be used for treating qi stagnation and blood stasis, pricking pain in chest and hypochondrium, menoxenia, amenorrhea and dysmenorrhea, breast pain, coma due to febrile disease, mania attack, hematemesis and epistaxis, female vicarious menstruation, damp-heat in liver and gallbladder, jaundice with dark urine, and gallbladder pain. The modern pharmacological research has the functions of promoting bile secretion and excretion, protecting liver, reducing blood viscosity, inhibiting platelet aggregation, resisting arrhythmia and inhibiting bacteria.

Radix ophiopogonis: sweet, slightly bitter and slightly cold. It enters heart, lung and stomach meridians. Nourish yin and moisten lung, nourish stomach and promote fluid production, clear heart and relieve restlessness. Can be used for treating dry cough due to lung dryness, cough due to yin deficiency, pharyngitis, pharyngalgia, stomach yin deficiency, thirst due to body fluid consumption, internal heat, diabetes, constipation due to intestinal dryness, heart yin deficiency, heart-heat disturbance to heart-nutrient, vexation, and insomnia due to epidemic febrile disease. Modern pharmacological research has the effects of increasing leucocytes, enhancing immunity, resisting cancer, resisting inflammation, calming, hypnotizing, resisting coagulation and the like.

Asparagus: sweet, bitter and cold. It enters lung and kidney meridians. To nourish yin, moisten dryness, clear lung and promote fluid production. Can be used for treating dry cough due to lung dryness, cough with sticky phlegm, cough with blood due to fatigue, deficiency of kidney yin, soreness of waist and knees, hectic fever due to yin deficiency, internal heat, diabetes, fluid impairment due to febrile disease, dry throat, thirst, and constipation due to intestinal dryness. The modern pharmacological research has the effects of relieving cough, eliminating phlegm, relieving asthma, reducing blood sugar, delaying senility, enhancing immunity, resisting tumor and resisting bacteria.

Licorice root: sweet and neutral. It enters heart, lung, spleen and stomach meridians. Invigorating spleen and replenishing qi, clearing away heat and toxic material, eliminating phlegm and relieving cough, relieving spasm and pain, and harmonizing the drugs. Can be used for treating weakness of spleen and stomach, asthenia, heart-qi deficiency, palpitation, short breath, intermittent pulse, swelling, sore throat, cough, excessive phlegm, spasm and pain of wrist, abdomen and limbs, and relieving drug toxicity and strong property. The modern pharmacological research has the effects of resisting arrhythmia, relieving cough, eliminating phlegm, relieving asthma, promoting urination, reducing blood lipid, protecting liver and having adrenocorticoid-like effect.

The traditional Chinese medicine composition for treating cough is applicable to treating the symptoms of external infection or internal injury with phlegm stasis obstructing lung and lung yin damage. Phlegm-blood stasis obstructing the lung and lung qi failing to disperse, manifested as itching throat, cough, lung yin damage, lung yin deficiency, even fire hyperactivity due to yin deficiency, yin fluid loss, lung dryness failing to moisten, dysfunction of qi movement, or internal heat due to yin deficiency, and lung collaterals injury due to deficient fire resulting in bleeding, a series of symptoms of dryness failing to moisten and deficient heat can appear. There are dry cough without phlegm, or less and sticky phlegm, dry mouth and throat itching, and the treatment method is mainly to ventilate lung and resolve phlegm, nourish yin to relieve cough, and clear heat and relieve asthma. The platycodon grandiflorum opens and ventilates lung qi, eliminates phlegm, relieves sore throat and expels pus, mainly treats cough with excessive phlegm, sore throat with hoarseness and lung carbuncle with pus, in the traditional Chinese medicine composition, the platycodon grandiflorum opens with bitter taste and releases, has mild medicine property and light weight, specially walks through the lung channel to be monarch medicine, and the medicine property is named as 'the platycodon grandiflorum opens the lung and relieves the chest distress and treats the throat'; bitter apricot kernel, semen Armeniacae amarum, as a monarch drug, has the actions of warming and moistening the descending, descending lung qi to relieve cough, moistening intestine and dryness to relieve constipation, and ventilating lung. The radix curcumae is pungent, bitter and slightly cold in nature, is used for promoting qi circulation and relieving depression by entering qi system, and achieves the purposes of cooling blood and removing blood stasis in blood system, promoting qi circulation and relieving distension, and cooling blood and clearing heart as ministerial drugs. The dwarf lilyturf tuber clears heart and moistens lung, nourishes stomach and generates body fluid, and nourishes yin and moistens dryness; radix asparagi has the effects of nourishing yin, clearing heat, moistening dryness, promoting the production of body fluid, moistening lung, relieving cough, and the radix ophiopogonis and radix asparagi are mutually reinforced to nourish yin, moisten dryness, not only clear lung-heat deficiency heat, but also heart, stomach and kidney deficiency heat, and benefit triple energizer, and are used as ministerial drugs. Raw licorice root, radix Glycyrrhizae Praeparata, having the effects of purging pathogenic fire and removing toxicity, moistening lung and eliminating phlegm to arrest cough, is used as an adjuvant drug in all kinds of diseases, and is said to be harmonious in all kinds of potency of herbs without the disadvantage of conflict in Job's de & ltten descriptions of the drugs with the drugs. In the formula of the Chinese medicinal composition, the liquorice and the platycodon root are used for clearing heat and relieving sore throat and treating cough, and on the basis, the almond is used for relieving cough, the radix curcumae is used for promoting qi circulation, the asparagus cochinchinensis and the radix ophiopogonis are used for nourishing yin, and the radix curcumae and the radix ophiopogonis used for clearing heart fire simultaneously and accords with the modern common cough pathogenesis.

The application comprises the following steps: the traditional Chinese medicine composition is mainly used for treating cough after cold, acute and chronic bronchitis, chronic obstructive lung disease, pertussis, pharyngeal cough and other diseases.

The traditional Chinese medicine composition comprises the following components: nausea and vomiting are easily caused by excessive dose of radix Platycodi, so it is not suitable for patients with adverse qi movement and chronic cough and hemoptysis due to yin deficiency, but it is killed and fearful to cooperate with radix asparagi and radix Ophiopogonis to reduce the side effects of radix Platycodi; the almond has little toxicity, the dosage is not suitable to be too large, the almond is used with caution for infants, and the liquorice can relieve the toxicity of the almond into mutual killing and mutual incompatibility; licorice should not be used for patients with fullness of middle energizer due to excessive dampness, and large dose of Licorice should not be taken for a long time, and it should not be combined with Hai Zao, Jing Da Ji, hong Da Ji, gan sui and Yuan Hua.

The traditional Chinese medicine composition is suitable for people who: children and adults over 3 years old.

The traditional Chinese medicine composition for treating cough provided by the invention has the beneficial effects that the cough can be safely and effectively treated; the six traditional Chinese medicines are utilized for combined treatment, mutual reinforcement, mutual incompatibility, mutual assistance, mutual killing, toxicity reduction and synergy among the medicines are fully utilized, and the traditional Chinese medicine composition helps patients to moisten lung, widen stomach, eliminate phlegm and relieve cough, promote qi circulation and relieve depression, clear heart and can effectively relieve clinical symptoms of the patients.

Detailed Description

The present invention will be described in further detail with reference to specific examples.

1. Preparation examples

1.1 weighing 10g of platycodon root, 6g of almond, 6g of turmeric root-tuber, 6g of dwarf lilyturf tuber, 3g of asparagus and 3g of liquorice. Making into medicinal powder with superfine pulverizing equipment (machine), sieving with at least 600 mesh sieve, and keeping. The powder is suitable for normal adult for 1 day, and can be used for treating cough. Is orally taken twice in the morning and evening.

1.2 weighing 10g of balloonflower root, 9g of almond, 9g of curcuma aromatica, 9g of dwarf lilyturf tuber, 6g of asparagus and 6g of liquorice. Making into medicinal powder with superfine pulverizing equipment (machine), sieving with at least 600 mesh sieve, and keeping. The powder is suitable for normal adult for 1 day, and can be used for treating cough. Is orally taken twice in the morning and evening.

1.3 weighing 10g of balloonflower root, 3g of almond, 3g of curcuma aromatica, 3g of dwarf lilyturf tuber, 1g of asparagus and 1g of liquorice. Making into medicinal powder with superfine pulverizing equipment (machine), sieving with at least 600 mesh sieve, and keeping. The powder is suitable for normal adult for 1 day, and can be used for treating cough. Is orally taken twice in the morning and evening.

1.4 weighing 10g of balloonflower root, 9g of almond, 6g of curcuma aromatica, 3g of dwarf lilyturf tuber, 3g of asparagus and 3g of liquorice. Making into medicinal powder with superfine pulverizing equipment (machine), sieving with at least 600 mesh sieve, and keeping. The powder is suitable for normal adult for 1 day, and can be used for treating cough. Is orally taken twice in the morning and evening.

1.5 weighing 10g of balloonflower root, 5g of almond, 6g of curcuma aromatica, 5g of dwarf lilyturf tuber, 2g of asparagus and 2g of liquorice. Making into medicinal powder with superfine pulverizing equipment (machine), sieving with at least 600 mesh sieve, and keeping. The powder is suitable for normal adult for 1 day, and can be used for treating cough. Is orally taken twice in the morning and evening.

1.6 weighing 10g of balloonflower root, 6g of almond, 5g of curcuma aromatica, 6g of dwarf lilyturf tuber, 4g of asparagus and 4g of liquorice. Making into medicinal powder with superfine pulverizing equipment (machine), sieving with at least 600 mesh sieve, and keeping. The powder is suitable for normal adult for 1 day, and can be used for treating cough. Is orally taken twice in the morning and evening.

The powder can be encapsulated for convenient administration, i.e. capsule administration. Or by

Material preparation → mold drawing → general molding → capping → drying → pill selection → coating → polishing → quality inspection → packaging. Making into watered pill for oral administration.

2. Clinical study of cough in the present invention

2.1 general data: the inventor observes 120 cough patients during 12 months in 2018 to 12 months in 2019, and the patients are diagnosed by clinicians and have the ages of 3 to 75 years, 61 cases in men and 59 cases in women, and are divided into groups according to the ages: 3-7 years old, 7-16 years old, 16-18 years old, 18-60 years old, 60-75 years old. The treatment effect is as follows:

(1) 22 patients of 3-7 years old are cured, 15 patients are cured, 5 patients are obviously effective, 1 patient is effective, and 0 patient is ineffective, and the effective rate is 95.45%;

(2) 24 patients of 7-16 years old are cured, 16 patients are cured, 7 patients are obviously effective, 0 patient is effective and 1 patient is ineffective, and the effective rate is 95.83%;

(3) 17 patients of 16-18 years old are cured by 15 patients, 1 patient with obvious effect, 1 patient with effect and 0 patient with no effect, and the effective rate is 100 percent;

(4) 29 patients of 18-60 years old are cured by 20 patients, 3 patients with obvious effect, 4 patients with effect and 2 patients with no effect, and the effective rate is 93.10%;

(5) 28 patients of 60-75 years old are cured by 19 patients, 4 patients with obvious effect, 4 patients with effective effect and 1 patient with ineffective effect, and the effective rate is 96.43 percent;

the total effective rate is 96.67%.

2.2 methods of treatment: the powder in the embodiment is orally taken, wherein the adult dose is divided into two times per day, and 5 days are a treatment course; 1/3 for 3-7 years old, and is suitable for adults, and 3 days is a treatment course; 1/2 for 7-16 years old, and 5 days as a treatment course.

2.3 treatment criteria:

and (3) curing: cough disappeared and was evaluated by Visual Analogue Scale (VAS) with score 0.

The effect is shown: cough symptoms were significantly reduced, and cough was assessed by Visual Analogue Scale (VAS) with a score >3 points less than before treatment.

The method has the following advantages: cough symptoms were reduced and evaluated by Visual Analogue Scale (VAS) with a score 1-3 points less than before treatment.

And (4) invalidation: cough was unchanged or increased and evaluated by Visual Analogue Scale (VAS) with no change or increase in score compared to before treatment.

2.4 treatment outcome: after the medicine is taken, the medicine takes effect within 1-3 days, 1-2 treatment courses cure the disease, and among 120 patients, 85 patients are cured, 20 patients take effect obviously, 10 patients take effect, 4 patients do not take effect, and the total effective rate is 96.67%.

Claims

1. A traditional Chinese medicine composition for treating cough is characterized in that: the paint comprises the following components in parts by weight:

2. The preparation method of the traditional Chinese medicine composition for treating cough as claimed in claim 1, which is carried out according to the following steps:

the component medicines are prepared by mixing the medicine components, preparing medicinal powder with a grade of at least 600 meshes by using superfine grinding equipment, and then preparing the medicinal powder into pills, powder or other dosage forms.

3. The preparation process flow of the watered pill of the traditional Chinese medicine composition for treating cough as claimed in claim 1: material preparation → mold drawing → general molding → capping → drying → pill selection → coating → polishing → quality inspection → packaging.