CN113031048A - Device and method for rapid quality control verification of ion beam range - Google Patents
Device and method for rapid quality control verification of ion beam range Download PDFInfo
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Abstract
The invention relates to a device and a method for fast quality control verification of ion beam range, which is characterized by comprising the following steps: the first wedge-shaped plate, the second wedge-shaped plate and the connecting rod; the first wedge-shaped plate and the second wedge-shaped plate are the same in structure and adopt an inclined stepped structure, and the inclined stepped structure comprises a plurality of layers of inclined steps which are sequentially arranged from top to bottom; each layer of inclined ladder of the first wedge-shaped plate and each layer of inclined ladder of the second wedge-shaped plate are arranged oppositely to form a symmetrical double-wedge-shaped device; the bottom inclined ladder bottom of the first wedge-shaped plate and the bottom inclined ladder bottom of the second wedge-shaped plate are both provided with bases with the same thickness, the middle parts of the bases are provided with holes for the connecting rods to penetrate through, and the first wedge-shaped plate and the second wedge-shaped plate are placed on the detector to be detected after the connecting rods are fixed. The invention can be widely applied to the field of radiation quality control of radiotherapy.
Description
Technical Field
The invention relates to the field of radiotherapy ray quality control molds, in particular to a device and a method for rapid quality control (QA) verification of an inclined stepped ion beam (proton/carbon ion) range.
Background
Currently, there are two types of beam distribution methods that have been used for clinical tumor therapy, one is a passive beam distribution method, such as a Heavy Ion Medical Accelerator (HIMAC) of national institute of radiation and medicine (NIRS); the other is an active beam distribution mode, represented by adopting a synchrotron active energy conversion and grid scanning system by the German heavy ion research center (GSI). In proton/heavy ion therapy, the depth dose distribution (Bragg curve) in the longitudinal direction of the ion beam can be converted into the dose distribution in the transverse direction through a wedge-shaped device, so that subsequent measurement can be carried out through different detection means (film, ionization chamber and the like), and the purpose of quick QA verification of the ion beam range can be achieved.
The wedge devices used in the conventional QA device for fast particle beam range verification are mainly divided into a single wedge plate and a double wedge plate. The single wedge plate is not high in measurement accuracy and large in quality, the double wedge plates can conduct quick QA verification on ion beam range through counting double-peak distances, measurement accuracy is high, the double wedge plates need to be placed on a detection device during measurement, the double wedge plates are also heavy in quality, burden can be generated on a detector, and the detector is required to be good in bearing performance.
Disclosure of Invention
Aiming at the problems, the invention aims to provide a device and a method for fast quality control verification of ion beam range, which adopt an inclined step type symmetrical double wedge shape, have simple structure, convenient use, high measurement precision and lighter weight, can be simultaneously applied to active/passive beam distribution, and can improve the defects existing in the prior art.
In order to achieve the purpose, the invention adopts the following technical scheme:
in a first aspect of the present invention, an apparatus for verifying fast quality control of ion beam range is provided, which includes: the first wedge-shaped plate, the second wedge-shaped plate and the connecting rod;
the first wedge-shaped plate and the second wedge-shaped plate are the same in structure and adopt an inclined stepped structure, and the inclined stepped structure comprises a plurality of layers of inclined steps which are sequentially arranged from top to bottom; each layer of inclined ladder of the first wedge-shaped plate and each layer of inclined ladder of the second wedge-shaped plate are arranged oppositely to form a symmetrical double-wedge-shaped device;
the bottom inclined ladder bottom of the first wedge-shaped plate and the bottom inclined ladder bottom of the second wedge-shaped plate are both provided with bases with the same thickness, the middle parts of the bases are provided with holes for the connecting rods to penetrate through, and the first wedge-shaped plate and the second wedge-shaped plate are placed on the detector to be detected after the connecting rods are fixed.
Further, in the first wedge plate and the second wedge plate, the height of the tilting step of the uppermost layer is greater than or equal to the height of the tilting step of each layer of the lower portion, and each layer of the lower portion the height of the tilting step is the same.
Further, the inclination angle of the uppermost inclined step and the inclined steps of the lower layers is within the range of 14-68 degrees.
Further, the first wedge-shaped plate and the second wedge-shaped plate are made of PMWA materials or AL materials; and the height of the uppermost inclined steps of the first wedge plate and the second wedge plate made of the PMWA material is 1.6 times that of the uppermost inclined steps of the first wedge plate and the second wedge plate made of the AL material.
Further, when the first wedge-shaped plate and the second wedge-shaped plate are made of PMWA materials, the height of the uppermost inclined step is 22 cm; when adopting the AL material preparation when first wedge board and second wedge board, the height of the topmost layer tilting ladder is 14 cm.
Further, the substrate thickness is 5 mm.
The device further comprises a supporting plate and a supporting frame, wherein the supporting plate and the supporting frame are detachably arranged between the first wedge-shaped plate and the detector to be detected, and are used for covering an energy interval required by active scanning treatment when active scanning measurement is carried out; wherein, backup pad and support frame all adopt with the same material preparation of first wedge board and second wedge board, just backup pad and support frame are the solid construction and the hollow structure of size unanimity respectively, backup pad and support frame punishment relatively do not are provided with arch and recess, and both are pegged graft fixedly of being convenient for.
Further, the thickness of the third supporting plate is 0.5-5 cm.
In a second aspect of the present invention, a method for verifying a device for verifying a fast quality control of an ion beam range is provided, which includes the following steps:
1) determining the material and related parameters of the inclined stepped symmetrical wedge device;
2) according to a passive scanning measurement or active scanning measurement mode, the inclined stepped symmetrical double-wedge-shaped device is placed at a corresponding position of the detector, so that the inclined stepped symmetrical double-wedge-shaped device can cover an energy interval required by radiotherapy;
3) and performing rapid quality control verification on the ion beam range according to the transverse dose distribution condition counted by the detection device.
Further, in the step 3), the method for performing fast quality control verification on the ion beam range according to the transverse dose distribution status counted by the detection device comprises:
during passive scanning, reversely calibrating the range of the carbon ion beams with different energies by counting the distance between the double peaks of the transverse dose;
in active scanning, the transverse dose distribution condition of carbon ion beams with different energies after passing through a wedge-shaped device is judged, when a large peak and a small peak are generated asymmetrically at the left side and the right side of the central position, the large peak at one side is used for calibrating the specific depth, and the small peak at the other side is used for reverse verification.
Due to the adoption of the technical scheme, the invention has the following advantages: 1. the invention converts the depth dose distribution of the ion beam in the longitudinal direction into the dose distribution in the transverse direction by arranging the inclined stepped symmetrical double-wedge plate, and the range of the carbon ion beam under the corresponding condition can be quickly determined by counting double peaks of the transverse dose through the detector.
2. According to the invention, when the PMMA inclined stepped wedge-shaped device (one side of which is not provided with the PMMA plate) is applied to passive scanning, the carbon ion beam range can be calibrated quickly and accurately by counting the transverse dose double-peak distance after uniform irradiation, and the AL inclined stepped wedge-shaped device is the same as the AL inclined stepped wedge-shaped device.
3. According to the invention, a plate with the same material thickness of 0.5-5cm (depending on the height difference between adjacent inclined steps) is added on one side of the inclined stepped wedge-shaped device, so that the active scanning device can be applied to active scanning. Two peak values (one is larger and the other is smaller) are generated at two sides of the center position asymmetrically, the large peak value at one side is used for calibrating the specific depth, the small peak value at the other side can be used for reverse verification, the testing accuracy is improved, and the weight is reduced on the basis of the original wedge-shaped device.
Therefore, the invention can be widely applied to the field of radiotherapy ray quality control molds.
Drawings
FIG. 1 is a schematic diagram of the connection between the apparatus for QA fast verification of ion beam range and the detector for passive scan measurement according to the embodiment of the present invention;
FIG. 2 is a schematic diagram of the connection between the apparatus for QA fast verification of ion beam range and the detector for active scanning measurement according to the embodiment of the present invention;
FIG. 3 is a schematic diagram of a support plate structure according to an embodiment of the present invention;
FIG. 4 is a schematic view of a support stand according to an embodiment of the present invention;
fig. 5 is a perspective view of the support frame in the embodiment of the invention.
Detailed Description
The invention is described in detail below with reference to the figures and examples.
The invention converts the depth dose distribution of the ion beam in the longitudinal direction into the dose distribution in the transverse direction by arranging the inclined stepped symmetrical double-wedge plate, and the range of the carbon ion beam under the corresponding condition can be quickly determined by counting double peaks of the transverse dose through the detector.
As shown in fig. 1-2, the present invention provides an apparatus for rapid QA verification of ion beam range, which includes: a first wedge plate 1, a second wedge plate 2 and a connecting rod 3. The first wedge-shaped plate 1 and the second wedge-shaped plate 2 are the same in structure and adopt an inclined stepped structure, and the inclined stepped structure comprises a plurality of layers of inclined steps which are sequentially arranged from top to bottom; each layer of inclined ladder of the first wedge-shaped plate and each layer of inclined ladder of the second wedge-shaped plate are arranged oppositely to form a symmetrical double-wedge-shaped device; the bottom of the lowest inclined ladder of the first wedge-shaped plate and the second wedge-shaped plate is provided with a substrate 4 with the same thickness, the middle of the substrate is provided with a hole for the connecting rod 3 to pass through, and the first wedge-shaped plate and the second wedge-shaped plate are placed on a detector 5 to be detected after being fixed through the connecting rod. Wherein the detector 5 to be detected may employ a large area detection device like matrix xx or lynx of IBA.
Further, the thickness of the base 4 at the bottom of the first wedge plate 1 and the second wedge plate 2 is 5 mm.
Further, in the first wedge-shaped plate 1 and the second wedge-shaped plate 2, the height of the uppermost inclined step can be greater than or equal to that of the lower inclined steps, the heights of the lower inclined steps are the same, the inclined angle (the included angle between the inclined surface and the vertical line) of the lower inclined steps is between 14 and 68 degrees, and the preferred angle is 45 degrees; the inclined angle interval of the uppermost inclined step is 14-68 degrees, and the preferred angle is 45 degrees or 63 degrees.
Further, the first wedge plate 1 and the second wedge plate 2 are made of PMWA material or AL material, and the height of the uppermost inclined step of the first wedge plate 1 and the second wedge plate 2 made of PMWA material is about 1.6 times the height of the uppermost inclined step of the first wedge plate 1 and the second wedge plate 2 made of AL material. Theoretically the larger the size, the higher the relative accuracy. According to actual needs, if effective space is considered, the wedge-shaped plate needs to be made smaller, and AL materials can be selected; if the relative accuracy is to be improved, PMMA material is selected.
Further, when the first wedge-shaped plate 1 and the second wedge-shaped plate 2 are made of PMWA materials, the height of the inclined ladder at the uppermost layer is about 22 cm; when the first wedge-shaped plate 1 and the second wedge-shaped plate 2 are made of AL materials, the height of the inclined ladder on the uppermost layer is about 14 cm.
Further, as shown in fig. 3 to 5, the device further includes a supporting plate 6 and a supporting frame 7, wherein the supporting plate 6 and the supporting frame 7 are detachably disposed between the first wedge-shaped plate 1 and the second wedge-shaped plate 2 and the detector 5 to be detected, and are used for covering an energy interval required by active scanning therapy when performing active scanning measurement. Wherein, backup pad 6 and support frame 7 all adopt with the first wedge board 1 with the same material preparation of second wedge board 2, and backup pad 7 and support frame 7 are the solid construction and the hollow structure of size unanimity respectively, backup pad 6 and support frame 7 punishment relatively do not are provided with arch and recess, both are convenient for peg graft fixedly.
Further, the thickness of the support plate 6 and the support bracket 7 is 0.5-5cm depending on the height difference between the adjacent inclined steps.
Based on the device for verifying the ion beam range by QA, the invention also provides a method for verifying the ion beam range by QA, which comprises the following steps:
1) and determining the material and related parameters of the inclined stepped symmetrical wedge device according to the test requirements.
As shown in fig. 1, it is a schematic diagram of a QA verifying apparatus with an inclined stepped ion beam range for PMMA material under the passive scanning of carbon ion beam; as shown in fig. 2, a schematic diagram of an oblique stepped ion beam range fast QA verification apparatus for PMMA material is shown after a supporting plate with a thickness of 0.5cm to 5cm (depending on the height difference between adjacent oblique steps) is added to one side of the apparatus under the active scanning of carbon ion beam.
2) According to a passive scanning measurement mode or an active scanning measurement mode, the inclined stepped symmetrical double-wedge-shaped device is placed at the corresponding position of the detector to be detected, so that the inclined stepped symmetrical double-wedge-shaped device can cover an energy interval required by radiotherapy.
When in passive scanning measurement, the inclined stepped symmetrical double-wedge device is directly placed on a detector to be detected, and the energy measurement range can cover the energy interval required by radiotherapy; during active scanning measurement, a supporting plate 6 made of the same material and having a thickness of 0.5cm-5cm (depending on the height difference between adjacent inclined steps) is placed on one side of the inclined stepped symmetrical double-wedge device, and a supporting frame 7 is placed on the other side of the inclined stepped symmetrical double-wedge device for supporting, so that an energy interval required by active scanning treatment is covered.
3) And performing rapid quality control verification on the ion beam range according to the transverse dose distribution condition counted by the detection device.
During passive scanning, after the ion beam passes through the inclined stepped wedge device, the transverse dose distribution condition is counted by the detection device. The carbon ion beam of different energies is passing through the horizontal dose distribution situation of wedge device back and is all symmetrical production horizontal dose peak value in central point position both sides, and the interval between the two peak values of horizontal dose increases along with the increase of energy, so accessible statistics horizontal dose two peak value intervals reverse scale not energetic carbon ion beam's range when passive form scans, and the accuracy is high to novel cascaded wedge device quality of slope is lighter, reduces the detector burden of weighing.
In active scanning, point scanning needs to sweep a line or a uniform field, and after an ion beam passes through the inclined stepped wedge device, the transverse dose distribution condition can be counted by the detection device. The transverse dose distribution condition of the carbon ion beams with different energies after passing through the wedge-shaped device is that a large peak value and a small peak value are generated on the left side and the right side of the central position asymmetrically, the large peak value on one side is used for calibrating the specific depth, and the small peak value on the other side can be used for reverse verification, so that the test precision is further improved, the weight is reduced on the level of the original wedge-shaped device, and the bearing pressure of a test detector is reduced.
The above embodiments are only used for illustrating the present invention, and the structure, connection mode, manufacturing process, etc. of the components may be changed, and all equivalent changes and modifications performed on the basis of the technical solution of the present invention should not be excluded from the protection scope of the present invention.
Claims (10)
1. The utility model provides a device that ion beam range quick quality control verified which characterized in that includes: the first wedge-shaped plate, the second wedge-shaped plate and the connecting rod;
the first wedge-shaped plate and the second wedge-shaped plate are the same in structure and adopt an inclined stepped structure, and the inclined stepped structure comprises a plurality of layers of inclined steps which are sequentially arranged from top to bottom; each layer of inclined ladder of the first wedge-shaped plate and each layer of inclined ladder of the second wedge-shaped plate are arranged oppositely to form a symmetrical double-wedge-shaped device;
the bottom inclined ladder bottom of the first wedge-shaped plate and the bottom inclined ladder bottom of the second wedge-shaped plate are both provided with bases with the same thickness, the middle parts of the bases are provided with holes for the connecting rods to penetrate through, and the first wedge-shaped plate and the second wedge-shaped plate are placed on the detector to be detected after the connecting rods are fixed.
2. The apparatus of claim 1, wherein the height of the uppermost inclined step of the first wedge plate and the second wedge plate is greater than or equal to the height of the lower inclined steps, and the heights of the lower inclined steps are the same.
3. The apparatus of claim 2, wherein the inclined angle of the uppermost inclined step and the inclined steps of the lower layers is in the range of 14-68 °.
4. The apparatus of claim 2, wherein the first wedge plate and the second wedge plate are made of PMWA material or AL material; and the height of the uppermost inclined steps of the first wedge plate and the second wedge plate made of the PMWA material is 1.6 times that of the uppermost inclined steps of the first wedge plate and the second wedge plate made of the AL material.
5. The apparatus for ion beam range fast quality control verification as claimed in claim 4, wherein when said first wedge plate and said second wedge plate are made of PMWA material, the height of said uppermost inclined step is 22 cm; when adopting the AL material preparation when first wedge board and second wedge board, the height of the topmost layer tilting ladder is 14 cm.
6. The apparatus of claim 1, wherein the substrate has a thickness of 5 mm.
7. The apparatus according to claim 1, further comprising a support plate and a support frame detachably disposed between the first wedge plate, the second wedge plate and the detector to be detected, for covering an energy interval required for active scanning during active scanning measurement; wherein, backup pad and support frame all adopt with the same material preparation of first wedge board and second wedge board, just backup pad and support frame are the solid construction and the hollow structure of size unanimity respectively, backup pad and support frame punishment relatively do not are provided with arch and recess, and both are pegged graft fixedly of being convenient for.
8. The apparatus of claim 1, wherein the third support plate has a thickness of 0.5-5 cm.
9. An authentication method using the apparatus for ion beam range rapid quality control authentication as claimed in any one of claims 1 to 8, comprising the steps of:
1) determining the material and related parameters of the inclined stepped symmetrical wedge device;
2) according to a passive scanning measurement or active scanning measurement mode, the inclined stepped symmetrical double-wedge-shaped device is placed at a corresponding position of the detector, so that the inclined stepped symmetrical double-wedge-shaped device can cover an energy interval required by radiotherapy;
3) and performing rapid quality control verification on the ion beam range according to the transverse dose distribution condition counted by the detection device.
10. The method of claim 9, wherein the step of verifying the ion beam range rapid quality control device comprises: in the step 3), the method for performing fast quality control verification on the ion beam range according to the transverse dose distribution condition counted by the detection device comprises the following steps:
during passive scanning, reversely calibrating the range of the carbon ion beams with different energies by counting the distance between the double peaks of the transverse dose;
in active scanning, the transverse dose distribution condition of carbon ion beams with different energies after passing through a wedge-shaped device is judged, when a large peak and a small peak are generated asymmetrically at the left side and the right side of the central position, the large peak at one side is used for calibrating the specific depth, and the small peak at the other side is used for reverse verification.
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