CN113018504A - Anti-allergic nasal liquid dressing and preparation method thereof - Google Patents
Anti-allergic nasal liquid dressing and preparation method thereof Download PDFInfo
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- CN113018504A CN113018504A CN202110263316.XA CN202110263316A CN113018504A CN 113018504 A CN113018504 A CN 113018504A CN 202110263316 A CN202110263316 A CN 202110263316A CN 113018504 A CN113018504 A CN 113018504A
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- nasal liquid
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- 230000003266 anti-allergic effect Effects 0.000 title claims abstract description 36
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- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims abstract description 18
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- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 claims description 2
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- GUGOEEXESWIERI-UHFFFAOYSA-N Terfenadine Chemical compound C1=CC(C(C)(C)C)=CC=C1C(O)CCCN1CCC(C(O)(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 GUGOEEXESWIERI-UHFFFAOYSA-N 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
- A61L26/0023—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0057—Ingredients of undetermined constitution or reaction products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
- A61L26/0066—Medicaments; Biocides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/23—Carbohydrates
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- A—HUMAN NECESSITIES
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
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- A61L2300/232—Monosaccharides, disaccharides, polysaccharides, lipopolysaccharides
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- A—HUMAN NECESSITIES
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- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/30—Compounds of undetermined constitution extracted from natural sources, e.g. Aloe Vera
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- A—HUMAN NECESSITIES
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- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
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- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
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- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Materials Engineering (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
The invention discloses an antiallergic nasal liquid dressing and a preparation method thereof, wherein the antiallergic nasal liquid dressing comprises the following components in percentage by mass: 50-95 parts of long-chain alkane, 40-50 parts of film forming agent, 30-40 parts of moisturizing bacteriostatic agent, 10-20 parts of low-molecular oligomeric hyaluronic acid, 15-20 parts of soothing and anti-inflammatory composition, 5-10 parts of sodium polyamino glucose carboxylate, 5-10 parts of compound protease and 3-5 parts of xanthium sibiricum extracting solution; the anti-allergic nasal liquid dressing system disclosed by the invention has the advantages of good moisture retention, adsorbability and air permeability, can form a protective film on the surface of skin or at positions such as a proboscis and the like, plays a role of physical barrier, can effectively block allergic substances, can be used as nasal liquid dressing and anti-allergic gel, and is mild, non-irritant, free of side effects and high in safety, and moisture-retention bacteriostats in the components are all natural plant polysaccharides.
Description
Technical Field
The invention relates to the field of anti-allergic dressings, in particular to an anti-allergic nasal liquid dressing and a preparation method thereof.
Background
Allergic rhinitis, i.e. allergic rhinitis, an allergen is an antigen that induces and reacts with specific lgE antibodies; they are mostly derived from animals, plants, insects, fungi or other allergic substances, and the allergens are mainly classified into inhalant allergens and food allergens; a method of treating allergic rhinitis comprising: 1. the curative effect of the drug treatment, such as antihistamine, glucocorticoid and anti-leukotriene, important drugs, can be different among different patients, and the long-term continuous curative effect is not achieved after the drug is stopped, so the sustained treatment of the persistent allergic rhinitis is needed; 2. immunotherapy, inducing clinical and immune tolerance, has long-term effects, and can prevent the development of allergic diseases; the allergen-specific immunotherapy is usually performed by subcutaneous injection and sublingual administration, the treatment course is divided into a dose accumulation stage and a dose maintenance stage, and the total treatment course is not less than 2 years; 3. the surgical treatment is carried out, the indication is that nasal obstruction symptoms are not improved through medicament or immunotherapy, the nasal obstruction symptoms have obvious physical signs and influence the life quality, and the nasal cavity has obvious anatomical variation accompanied with functional disorder; 4. the contact with the allergen is avoided, the method is simple and effective, but the inhalant allergen is difficult to avoid by using the conventional method;
in conclusion, the existing treatment methods for allergic rhinitis have shortcomings and cannot adapt to the sudden nasal allergy problem; therefore, the invention provides an antiallergic nasal liquid dressing and a preparation method thereof, and aims to overcome the defects in the prior art.
Disclosure of Invention
In view of the above problems, an object of the present invention is to provide an anti-allergic nasal liquid dressing and a preparation method thereof, wherein the anti-allergic nasal liquid dressing has the advantages of good moisture retention, adsorbability and breathability, can form a protective film on the skin surface or at the anterior nasal atrium, and the like, plays a role of physical barrier, can effectively block allergic substances, and can be used as a nasal liquid dressing and an anti-nasal allergy gel.
In order to achieve the purpose of the invention, the invention is realized by the following technical scheme:
an antiallergic nasal liquid dressing comprises the following components in percentage by mass: 50-95 parts of long-chain alkane, 40-50 parts of film forming agent, 30-40 parts of moisturizing bacteriostatic agent, 10-20 parts of low-molecular oligomeric hyaluronic acid, 15-20 parts of soothing and anti-inflammatory composition, 5-10 parts of sodium polyamino glucose carboxylate, 5-10 parts of compound protease and 3-5 parts of xanthium sibiricum extracting solution.
The further improvement lies in that: comprises the following components in percentage by mass: 85 parts of long-chain alkane, 45 parts of film forming agent, 35 parts of moisturizing bacteriostatic agent, 15 parts of low-molecular oligomeric hyaluronic acid, 18 parts of soothing anti-inflammatory composition, 8 parts of sodium polyglucose carboxylate, 7 parts of compound protease and 4 parts of xanthium sibiricum extracting solution.
The further improvement lies in that: the long-chain alkane is one or a mixture of vaseline and paraffin.
The further improvement lies in that: the moisture-keeping bacteriostatic agent is any five or more of Tremella polysaccharide, Atractylodis rhizoma polysaccharide, pachyman, corn polysaccharide, fructus Hippophae polysaccharide, Aloe polysaccharide, rhizoma Dioscoreae polysaccharide, radix astragali polysaccharide, Ganoderma polysaccharide, radix Ophiopogonis polysaccharide, Coicis semen polysaccharide, fructus Psidii Guajavae Immaturus polysaccharide, laminarin, and semen Ginkgo polysaccharide.
The further improvement lies in that: the film forming agent is any one of xanthan gum, polydimethylsiloxane, carbomer, jojoba oil, agar and carrageenan.
The further improvement lies in that: the low-molecular oligomeric hyaluronic acid is enzyme-digested oligomeric sodium hyaluronate with the molecular weight of 5000dal-8000 dal.
The further improvement lies in that: the soothing anti-inflammatory composition comprises chamomile flower extract, aloe extract, purslane extract, dipotassium glycyrrhizinate, centella extract and tea extract.
The further improvement lies in that: the compound protease is any one or combination of snail protease, bromelain and papain.
The further improvement lies in that: the preparation process of the xanthium sibiricum extracting solution comprises the following steps: firstly, grinding xanthium sibiricum to obtain xanthium sibiricum powder, then soaking the xanthium sibiricum powder and propylene glycol according to the proportion of 1:20 at the constant temperature of 60-70 ℃ for 2 hours, and then filtering to obtain the xanthium sibiricum extracting solution.
A preparation method of an antiallergic nasal liquid dressing comprises the following steps:
the method comprises the following steps: heating long-chain alkane to melt at 75-85 ℃ to obtain a long-chain alkane solution, and then mixing and stirring low-molecular oligomeric hyaluronic acid and the long-chain alkane solution for the first time to obtain a first prepared solution;
step two: adding the long-chain alkane solution, the soothing anti-inflammatory composition, the sodium polyamino glucose carboxylate, the film forming agent and the xanthium sibiricum extracting solution into the first prepared solution, mixing and stirring for the second time, and controlling the temperature to be 60-65 ℃ in the stirring process to obtain a second prepared solution;
step three: and cooling the second preparation solution to 45-50 ℃, and then adding the compound protease to carry out mixing and stirring for the third time to obtain the liquid dressing.
The invention has the beneficial effects that: the anti-allergic nasal liquid dressing system has good moisture retention, has the advantages of both adsorptivity and air permeability, can form a protective film on the surface of skin or at the positions of anterior rhinotine and the like, plays a role of physical barrier, can effectively block allergic substances, can be used as nasal liquid dressing and anti-allergic gel, is mild and non-irritant, has no side effect and high safety, is extracted from natural plants as a relieving and anti-inflammatory composition, has the effects of calming and relieving the skin, resisting inflammation and resisting microbial infection, can effectively relieve the nasal pruritus problem caused by allergy, has the effects of promoting angiogenesis, cell proliferation, wound repair, skin light injury repair and deep skin moisturizing, can effectively moisten the nasal cavity and relieve uncomfortable feeling, and can effectively promote abnormal keratinocyte repair and regeneration by compound protease, has excellent antipruritic effect.
Detailed Description
In order to further understand the present invention, the following detailed description will be made with reference to the following examples, which are only used for explaining the present invention and are not to be construed as limiting the scope of the present invention.
Example one
The embodiment provides an antiallergic nasal liquid dressing, which comprises the following components in percentage by mass: 50 parts of long-chain alkane, 40 parts of film forming agent, 30 parts of moisturizing bacteriostatic agent, 10 parts of low-molecular oligomeric hyaluronic acid, 15 parts of soothing anti-inflammatory composition, 5 parts of sodium polyglucose carboxylate, 5 parts of compound protease and 3 parts of xanthium sibiricum extracting solution.
The long-chain alkane is a mixture of vaseline and paraffin.
The moisture-keeping bacteriostatic agent is a mixture of tremella polysaccharide, Atractylodis rhizoma polysaccharide, pachyman, corn polysaccharide, fructus Hippophae polysaccharide, Aloe polysaccharide, rhizoma Dioscoreae polysaccharide, radix astragali polysaccharide, Ganoderma polysaccharide, radix Ophiopogonis polysaccharide, Coicis semen polysaccharide, fructus Psidii Guajavae Immaturus polysaccharide, laminarin and semen Ginkgo polysaccharide.
The film forming agent is jojoba oil.
The low molecular oligomeric hyaluronic acid is enzyme-digested oligomeric sodium hyaluronate with the molecular weight of 6000 dal.
The soothing anti-inflammatory composition comprises chamomile flower extract, aloe extract, purslane extract, dipotassium glycyrrhizinate, centella extract and tea extract.
The compound protease is snail protease.
The preparation process of the xanthium sibiricum extracting solution comprises the following steps: firstly, grinding xanthium sibiricum to obtain xanthium sibiricum powder, then soaking the xanthium sibiricum powder and propylene glycol at the constant temperature of 65 ℃ for 2 hours according to the proportion of 1:20, and then filtering to obtain the xanthium sibiricum extracting solution.
A preparation method of an antiallergic nasal liquid dressing comprises the following steps:
the method comprises the following steps: heating long-chain alkane to melt at 80 ℃ to obtain a long-chain alkane solution, and then mixing and stirring low-molecular oligomeric hyaluronic acid and the long-chain alkane solution for the first time to obtain a first prepared solution;
step two: adding the long-chain alkane solution, the soothing anti-inflammatory composition, the sodium polyamino glucose carboxylate, the film forming agent and the xanthium sibiricum extracting solution into the first prepared solution, mixing and stirring for the second time, and controlling the temperature to be 62 ℃ in the stirring process to obtain a second prepared solution;
step three: and cooling the second preparation solution to 48 ℃, and then adding compound protease to carry out third mixing and stirring to obtain the liquid dressing.
Example two
The embodiment provides an antiallergic nasal liquid dressing, which comprises the following components in percentage by mass: 85 parts of long-chain alkane, 45 parts of film forming agent, 35 parts of moisturizing bacteriostatic agent, 15 parts of low-molecular oligomeric hyaluronic acid, 18 parts of soothing anti-inflammatory composition, 8 parts of sodium polyglucose carboxylate, 7 parts of compound protease and 4 parts of xanthium sibiricum extracting solution.
The long-chain alkane is a mixture of vaseline and paraffin.
The moisture-keeping bacteriostatic agent is a mixture of tremella polysaccharide, Atractylodis rhizoma polysaccharide, pachyman, corn polysaccharide, fructus Hippophae polysaccharide, Aloe polysaccharide, rhizoma Dioscoreae polysaccharide, radix astragali polysaccharide, Ganoderma polysaccharide, radix Ophiopogonis polysaccharide, Coicis semen polysaccharide, fructus Psidii Guajavae Immaturus polysaccharide, laminarin and semen Ginkgo polysaccharide.
The film forming agent is jojoba oil.
The low molecular oligomeric hyaluronic acid is enzyme-digested oligomeric sodium hyaluronate with the molecular weight of 6000 dal.
The soothing anti-inflammatory composition comprises chamomile flower extract, aloe extract, purslane extract, dipotassium glycyrrhizinate, centella extract and tea extract.
The compound protease is snail protease.
The preparation process of the xanthium sibiricum extracting solution comprises the following steps: firstly, grinding xanthium sibiricum to obtain xanthium sibiricum powder, then soaking the xanthium sibiricum powder and propylene glycol at the constant temperature of 65 ℃ for 2 hours according to the proportion of 1:20, and then filtering to obtain the xanthium sibiricum extracting solution.
A preparation method of an antiallergic nasal liquid dressing comprises the following steps:
the method comprises the following steps: heating long-chain alkane to melt at 80 ℃ to obtain a long-chain alkane solution, and then mixing and stirring low-molecular oligomeric hyaluronic acid and the long-chain alkane solution for the first time to obtain a first prepared solution;
step two: adding the long-chain alkane solution, the soothing anti-inflammatory composition, the sodium polyamino glucose carboxylate, the film forming agent and the xanthium sibiricum extracting solution into the first prepared solution, mixing and stirring for the second time, and controlling the temperature to be 62 ℃ in the stirring process to obtain a second prepared solution;
step three: and cooling the second preparation solution to 48 ℃, and then adding compound protease to carry out third mixing and stirring to obtain the liquid dressing.
EXAMPLE III
The embodiment provides an antiallergic nasal liquid dressing, which comprises the following components in percentage by mass: 95 parts of long-chain alkane, 50 parts of film forming agent, 40 parts of moisturizing bacteriostatic agent, 20 parts of low-molecular oligomeric hyaluronic acid, 20 parts of soothing anti-inflammatory composition, 10 parts of sodium polyglucose carboxylate, 10 parts of compound protease and 5 parts of xanthium sibiricum extracting solution.
The long-chain alkane is a mixture of vaseline and paraffin.
The moisture-keeping bacteriostatic agent is a mixture of tremella polysaccharide, Atractylodis rhizoma polysaccharide, pachyman, corn polysaccharide, fructus Hippophae polysaccharide, Aloe polysaccharide, rhizoma Dioscoreae polysaccharide, radix astragali polysaccharide, Ganoderma polysaccharide, radix Ophiopogonis polysaccharide, Coicis semen polysaccharide, fructus Psidii Guajavae Immaturus polysaccharide, laminarin and semen Ginkgo polysaccharide.
The film forming agent is jojoba oil.
The low molecular oligomeric hyaluronic acid is enzyme-digested oligomeric sodium hyaluronate with the molecular weight of 6000 dal.
The soothing anti-inflammatory composition comprises chamomile flower extract, aloe extract, purslane extract, dipotassium glycyrrhizinate, centella extract and tea extract.
The compound protease is snail protease.
The preparation process of the xanthium sibiricum extracting solution comprises the following steps: firstly, grinding xanthium sibiricum to obtain xanthium sibiricum powder, then soaking the xanthium sibiricum powder and propylene glycol at the constant temperature of 65 ℃ for 2 hours according to the proportion of 1:20, and then filtering to obtain the xanthium sibiricum extracting solution.
A preparation method of an antiallergic nasal liquid dressing comprises the following steps:
the method comprises the following steps: heating long-chain alkane to melt at 80 ℃ to obtain a long-chain alkane solution, and then mixing and stirring low-molecular oligomeric hyaluronic acid and the long-chain alkane solution for the first time to obtain a first prepared solution;
step two: adding the long-chain alkane solution, the soothing anti-inflammatory composition, the sodium polyamino glucose carboxylate, the film forming agent and the xanthium sibiricum extracting solution into the first prepared solution, mixing and stirring for the second time, and controlling the temperature to be 62 ℃ in the stirring process to obtain a second prepared solution;
step three: and cooling the second preparation solution to 48 ℃, and then adding compound protease to carry out third mixing and stirring to obtain the liquid dressing.
Examples of the experiments
Randomly selecting 8 allergic rhinitis patients to perform an experiment, then applying the liquid dressing prepared in any one of the first embodiment, the second embodiment and the third embodiment of the invention in the anterior nasal atrium of the 8 allergic rhinitis patients, then respectively carrying out nasal cavity mucus sampling detection in the anterior nasal atrium of the 8 allergic rhinitis patients at 30, 60, 90 and 120 minutes after the experiment, and simultaneously carrying out questionnaire survey on the somatic sensation of the patients to obtain the following experiment results shown in tables 1 and 2:
TABLE 1
TABLE 2
According to the results in tables 1 and 2, the antiallergic nasal liquid dressing provided by the invention can effectively intercept allergic substances when being applied to the anterior nasal atrium of allergic rhinitis patients, the antiallergic effect is best at 120 th minute, a large amount of allergic substances can be intercepted, and the antiallergic nasal liquid dressing provided by the invention can obviously reduce itching caused by allergy within 30 minutes, and can quickly and effectively reduce uncomfortable feeling.
The invention has the beneficial effects that: the anti-allergic nasal liquid dressing system has good moisture retention, has the advantages of both adsorptivity and air permeability, can form a protective film on the surface of skin or at the positions of anterior rhinotine and the like, plays a role of physical barrier, can effectively block allergic substances, can be used as nasal liquid dressing and anti-allergic gel, is mild and non-irritant, has no side effect and high safety, is extracted from natural plants as a relieving and anti-inflammatory composition, has the effects of calming and relieving the skin, resisting inflammation and resisting microbial infection, can effectively relieve the nasal pruritus problem caused by allergy, has the effects of promoting angiogenesis, cell proliferation, wound repair, skin light injury repair and deep skin moisturizing, can effectively moisten the nasal cavity and relieve uncomfortable feeling, and can effectively promote abnormal keratinocyte repair and regeneration by compound protease, has excellent antipruritic effect.
The foregoing illustrates and describes the principles, general features, and advantages of the present invention. It will be understood by those skilled in the art that the present invention is not limited to the embodiments described above, which are described in the specification and illustrated only to illustrate the principle of the present invention, but that various changes and modifications may be made therein without departing from the spirit and scope of the present invention, which fall within the scope of the invention as claimed. The scope of the invention is defined by the appended claims and equivalents thereof.
Claims (10)
1. An anti-allergic nasal liquid dressing, which is characterized in that: comprises the following components in percentage by mass: 50-95 parts of long-chain alkane, 40-50 parts of film forming agent, 30-40 parts of moisturizing bacteriostatic agent, 10-20 parts of low-molecular oligomeric hyaluronic acid, 15-20 parts of soothing and anti-inflammatory composition, 5-10 parts of sodium polyamino glucose carboxylate, 5-10 parts of compound protease and 3-5 parts of xanthium sibiricum extracting solution.
2. The anti-allergic nasal liquid dressing according to claim 1, wherein: comprises the following components in percentage by mass: 85 parts of long-chain alkane, 45 parts of film forming agent, 35 parts of moisturizing bacteriostatic agent, 15 parts of low-molecular oligomeric hyaluronic acid, 18 parts of soothing anti-inflammatory composition, 8 parts of sodium polyglucose carboxylate, 7 parts of compound protease and 4 parts of xanthium sibiricum extracting solution.
3. The anti-allergic nasal liquid dressing according to claim 1, wherein: the long-chain alkane is one or a mixture of vaseline and paraffin.
4. The anti-allergic nasal liquid dressing according to claim 1, wherein: the moisture-keeping bacteriostatic agent is any five or more of Tremella polysaccharide, Atractylodis rhizoma polysaccharide, pachyman, corn polysaccharide, fructus Hippophae polysaccharide, Aloe polysaccharide, rhizoma Dioscoreae polysaccharide, radix astragali polysaccharide, Ganoderma polysaccharide, radix Ophiopogonis polysaccharide, Coicis semen polysaccharide, fructus Psidii Guajavae Immaturus polysaccharide, laminarin, and semen Ginkgo polysaccharide.
5. The anti-allergic nasal liquid dressing according to claim 1, wherein: the film forming agent is any one of xanthan gum, polydimethylsiloxane, carbomer, jojoba oil, agar and carrageenan.
6. The anti-allergic nasal liquid dressing according to claim 1, wherein: the low-molecular oligomeric hyaluronic acid is enzyme-digested oligomeric sodium hyaluronate with the molecular weight of 5000dal-8000 dal.
7. The anti-allergic nasal liquid dressing according to claim 1, wherein: the soothing anti-inflammatory composition comprises chamomile flower extract, aloe extract, purslane extract, dipotassium glycyrrhizinate, centella extract and tea extract.
8. The anti-allergic nasal liquid dressing according to claim 1, wherein: the compound protease is any one or combination of snail protease, bromelain and papain.
9. The anti-allergic nasal liquid dressing according to claim 1, wherein: the preparation process of the xanthium sibiricum extracting solution comprises the following steps: firstly, grinding xanthium sibiricum to obtain xanthium sibiricum powder, then soaking the xanthium sibiricum powder and propylene glycol according to the proportion of 1:20 at the constant temperature of 60-70 ℃ for 2 hours, and then filtering to obtain the xanthium sibiricum extracting solution.
10. The preparation method of the anti-allergic nasal liquid dressing is characterized by comprising the following steps:
the method comprises the following steps: heating long-chain alkane to melt at 75-85 ℃ to obtain a long-chain alkane solution, and then mixing and stirring low-molecular oligomeric hyaluronic acid and the long-chain alkane solution for the first time to obtain a first prepared solution;
step two: adding the long-chain alkane solution, the soothing anti-inflammatory composition, the sodium polyamino glucose carboxylate, the film forming agent and the xanthium sibiricum extracting solution into the first prepared solution, mixing and stirring for the second time, and controlling the temperature to be 60-65 ℃ in the stirring process to obtain a second prepared solution;
step three: and cooling the second preparation solution to 45-50 ℃, and then adding the compound protease to carry out mixing and stirring for the third time to obtain the liquid dressing.
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Application publication date: 20210625 |