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CN112999131A - Anti-wrinkle repair composition suitable for pressure skin and essence emulsion product thereof - Google Patents

Anti-wrinkle repair composition suitable for pressure skin and essence emulsion product thereof Download PDF

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Publication number
CN112999131A
CN112999131A CN202110179277.5A CN202110179277A CN112999131A CN 112999131 A CN112999131 A CN 112999131A CN 202110179277 A CN202110179277 A CN 202110179277A CN 112999131 A CN112999131 A CN 112999131A
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Prior art keywords
parts
extract
repair composition
wrinkle repair
wrinkle
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Inventor
黄伟
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Guangzhou Zhenji Hemei Biotechnology Co ltd
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Guangzhou Zhenji Hemei Biotechnology Co ltd
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Priority to CN202110179277.5A priority Critical patent/CN112999131A/en
Publication of CN112999131A publication Critical patent/CN112999131A/en
Pending legal-status Critical Current

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783Angiosperms [Magnoliophyta]
    • A61K8/9794Liliopsida [monocotyledons]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34Alcohols
    • A61K8/345Alcohols containing more than one hydroxy group
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/44Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/60Sugars; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/68Sphingolipids, e.g. ceramides, cerebrosides, gangliosides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73Polysaccharides
    • A61K8/735Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A61K8/922Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9706Algae
    • A61K8/9717Rhodophycota or Rhodophyta [red algae], e.g. Porphyra
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9728Fungi, e.g. yeasts
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783Angiosperms [Magnoliophyta]
    • A61K8/9789Magnoliopsida [dicotyledons]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/08Anti-ageing preparations
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/59Mixtures
    • A61K2800/592Mixtures of compounds complementing their respective functions
    • A61K2800/5922At least two compounds being classified in the same subclass of A61K8/18
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/74Biological properties of particular ingredients
    • A61K2800/78Enzyme modulators, e.g. Enzyme agonists
    • A61K2800/782Enzyme inhibitors; Enzyme antagonists

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  • Oil, Petroleum & Natural Gas (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Gerontology & Geriatric Medicine (AREA)
  • Emergency Medicine (AREA)
  • Cosmetics (AREA)

Abstract

The invention discloses an anti-wrinkle repair composition suitable for pressure skin and an essence emulsion product thereof; the anti-wrinkle repair composition comprises the following raw materials in parts by weight: 0.01-20 parts of ceramide, 0.01-20 parts of phytosphingosine, 0.01-20 parts of turmeric root extract, 0.01-20 parts of nightshade extract, 0.01-20 parts of creatine, 0.01-20 parts of prinsepia utilis royle oil, 0.01-20 parts of chamomile extract, 0.01-20 parts of centella extract, 0.01-20 parts of aloe barbadensis extract, 0.01-20 parts of sophora flavescens root extract, 0.01-20 parts of hamamelis extract, 0.01-20 parts of poria cocos sclerotium extract, 0.01-20 parts of apple extract and 0.01-20 parts of seabuckthorn fruit extract; meanwhile, the essence milk product prepared from the anti-wrinkle repair composition has excellent collagen synthesis promoting effect, oxidation free radical removing efficiency and anti-wrinkle skin care effectiveness.

Description

Anti-wrinkle repair composition suitable for pressure skin and essence emulsion product thereof
Technical Field
The invention relates to the field of cosmetics, in particular to an anti-wrinkle repair composition suitable for pressure skin and an essence emulsion product thereof.
Background
The skin is our collective protective barrier, and is the first line of defense we are against foreign "aggressors". Modern people have fast pace of life, and many things influencing the mood and the mood of people can bring positive or negative pressure to the body of people. We may face social, psychological, physical and environmental stresses. When a person feels stress, the stress hormones (e.g., cortisol) in the body rise, which can cause water loss, penetration of some of the epidermal irritants into the skin, can cause oily skin, acne and other related skin problems, can cause a fatigued skin appearance, and can even cause a series of problems such as fine lines and wrinkles.
In order to solve the problems of skin caused by stress, repair damaged skin, improve wrinkles and roughness of skin, and care stressed skin, it is urgently required to develop a skin repair composition which can effectively cope with the stressed skin and has a similar composition to the natural composition of skin.
However, in the process of implementing the technical solution of the invention in the embodiment of the present application, the inventor of the present application finds that at least the following technical problems exist in the prior art:
the prior art (CN104173207B) discloses a skin barrier repair preparation comprising the following components: deionized water, sucrose stearate, phytosterol isostearate, vitamin E, glycerol, butanediol, 1, 2-pentanediol, octyldodecanol, polydimethylsiloxane, hydrogenated polyisobutene, oleic acid, linoleic acid, ceramide 2, ceramide 3, ceramide 6II, sodium hyaluronate, xanthan gum, EDTA disodium, acrylic acid/C10-30 alkanol acrylate cross-linked polymer, allantoin and sorbitan caprylate, and also provides a preparation method of the skin barrier repair preparation. However, the technical components have various contents and complex preparation process, and various expensive raw materials are required to be added, so that the cost is increased, and the various raw materials are doped at the same time, and the effects of strongly repairing and protecting the skin are not necessarily achieved.
Therefore, the preparation of a product which has a reasonable formula and can play a good role in repairing and caring the skin is very meaningful work.
Disclosure of Invention
In order to solve the problems, the invention provides an anti-wrinkle repair composition suitable for pressure skin, which comprises the following raw materials in parts by weight: 0.01-20 parts of ceramide, 0.01-20 parts of phytosphingosine, 0.01-20 parts of creatine, 0.01-20 parts of prinsepia utilis royle oil and 0.1-200 parts of plant extract.
As a preferred embodiment, the plant extract comprises the following components in parts by weight: 0.01-20 parts of turmeric root extract, 0.01-20 parts of nightshade extract, 0.01-20 parts of white flower chamomile extract, 0.01-20 parts of centella extract, 0.01-20 parts of aloe barbadensis extract, 0.01-20 parts of sophora flavescens root extract, 0.01-20 parts of hamamelis extract, 0.01-20 parts of poria cocos sclerotium extract, 0.01-20 parts of apple extract and 0.01-20 parts of seabuckthorn fruit extract.
As a preferable scheme, the weight ratio of the turmeric root extract to the withania extract is 0.1-1: 1 to 5.
Preferably, the weight ratio of ceramide to phytosphingosine is 1-5: 0.05 to 1.2.
The invention provides an essence emulsion containing the anti-wrinkle repair composition suitable for the pressure skin, which comprises the following raw materials in parts by weight: 0.1-20 parts of anti-wrinkle repair composition suitable for pressure skin, 0.1-1 part of thickening agent, 0.1-1 part of preservative, 2-5 parts of humectant, 2-5 parts of emulsifier, 10-20 parts of emollient and 48-85.7 parts of water.
In a preferred embodiment, the humectant is at least one of butylene glycol, sodium hyaluronate, carrageen, trehalose, and glycerin.
As a preferred scheme, the humectant is trehalose and carrageen crispa; the weight ratio of the trehalose to the carrageen crispa is 2-3: 1 to 2.
As a preferred scheme, the thickening agent is at least one of carbomer, xanthan gum and hydroxyethyl cellulose.
In a preferred embodiment, the emulsifier is at least one of polyglyceryl-3-methylglucidistearate, cetearyl alcohol and hydrogenated lecithin.
According to the invention, the preparation method of the essence milk product containing the anti-wrinkle repair composition suitable for the pressure skin comprises the following steps: (1) adding the emollient and the emulsifier into a proper container, and uniformly stirring and dispersing; (2) heating the antiseptic to 80 deg.C for dissolving and dispersing, adding the rest materials into another container, adding water, and mixing; (3) and (3) uniformly mixing the components (1) and adding the mixture into the container (2), and uniformly stirring and mixing to obtain a finished product.
Has the advantages that: the invention discloses an anti-wrinkle repair composition suitable for pressure skin and an essence emulsion product thereof; the compound of ceramide and phytosphingosine, the compound of turmeric root extract and nightshade extract and the addition of the compound humectant in the raw materials for preparing the anti-wrinkle repair composition stimulate the activity of each active ingredient in the raw materials, effectively improve the capabilities of the essence milk product in repairing damaged skin, improving wrinkles and roughness of skin and caring stressed skin.
Detailed Description
The disclosure may be understood more readily by reference to the following detailed description of preferred embodiments of the invention and the examples included therein. Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. In case of conflict, the present specification, including definitions, will control.
The term "prepared from …" as used herein is synonymous with "comprising". The terms "comprises," "comprising," "includes," "including," "has," "having," "contains," "containing," or any other variation thereof, as used herein, are intended to cover a non-exclusive inclusion. For example, a composition, process, method, article, or apparatus that comprises a list of elements is not necessarily limited to only those elements but may include other elements not expressly listed or inherent to such composition, process, method, article, or apparatus.
The conjunction "consisting of …" excludes any unspecified elements, steps or components. If used in a claim, the phrase is intended to claim as closed, meaning that it does not contain materials other than those described, except for the conventional impurities associated therewith. When the phrase "consisting of …" appears in a clause of the subject matter of the claims rather than immediately after the subject matter, it defines only the elements described in the clause; other elements are not excluded from the claims as a whole.
When an amount, concentration, or other value or parameter is expressed as a range, preferred range, or as a range of upper preferable values and lower preferable values, this is to be understood as specifically disclosing all ranges formed from any pair of any upper range limit or preferred value and any lower range limit or preferred value, regardless of whether ranges are separately disclosed. For example, when a range of "1 to 5" is disclosed, the described range should be interpreted to include the ranges "1 to 4", "1 to 3", "1 to 2 and 4 to 5", "1 to 3 and 5", and the like. When a range of values is described herein, unless otherwise stated, the range is intended to include the endpoints thereof and all integers and fractions within the range.
The singular forms "a", "an" and "the" include plural referents unless the context clearly dictates otherwise. "optional" or "any" means that the subsequently described event or events may or may not occur, and that the description includes instances where the event occurs and instances where it does not.
Approximating language, as used herein throughout the specification and claims, is intended to modify a quantity, such that the invention is not limited to the specific quantity, but includes portions that are literally received for modification without substantial change in the basic function to which the invention is related. Accordingly, the use of "about" to modify a numerical value means that the invention is not limited to the precise value. In some instances, the approximating language may correspond to the precision of an instrument for measuring the value. In the present description and claims, range limitations may be combined and/or interchanged, including all sub-ranges contained therein if not otherwise stated.
In addition, the indefinite articles "a" and "an" preceding an element or component of the invention are not intended to limit the number requirement (i.e., the number of occurrences) of the element or component. Thus, "a" or "an" should be read to include one or at least one, and the singular form of an element or component also includes the plural unless the stated number clearly indicates that the singular form is intended.
In order to solve the problems, the invention provides an anti-wrinkle repair composition suitable for pressure skin, which comprises the following raw materials in parts by weight: 0.01-20 parts of ceramide, 0.01-20 parts of phytosphingosine, 0.01-20 parts of creatine, 0.01-20 parts of prinsepia utilis royle oil and 0.1-200 parts of plant extract.
In some preferred embodiments, the plant extract comprises the following parts by weight: 0.01-20 parts of turmeric root extract, 0.01-20 parts of nightshade extract, 0.01-20 parts of white flower chamomile extract, 0.01-20 parts of centella extract, 0.01-20 parts of aloe barbadensis extract, 0.01-20 parts of sophora flavescens root extract, 0.01-20 parts of hamamelis extract, 0.01-20 parts of poria cocos sclerotium extract, 0.01-20 parts of apple extract and 0.01-20 parts of seabuckthorn fruit extract.
In some preferred embodiments, the anti-wrinkle repair composition suitable for pressure skin comprises the following raw materials in parts by weight: 1-18 parts of ceramide, 1-18 parts of phytosphingosine, 1-18 parts of creatine, 1-18 parts of prinsepia utilis royle oil, 1-18 parts of turmeric root extract, 1-18 parts of nightshade extract, 1-18 parts of chamomile extract, 1-18 parts of centella asiatica extract, 1-18 parts of aloe barbadensis extract, 1-18 parts of sophora flavescens ait root extract, 1-18 parts of hamamelis extract, 1-18 parts of poria cocos sclerotium extract, 1-18 parts of apple fruit extract and 1-18 parts of seabuckthorn fruit extract.
In some preferred embodiments, the anti-wrinkle repair composition suitable for pressure skin comprises the following raw materials in parts by weight: 4-16 parts of ceramide, 4-16 parts of phytosphingosine, 4-16 parts of creatine, 4-16 parts of prinsepia utilis royle oil, 4-16 parts of turmeric root extract, 4-16 parts of nightshade extract, 4-16 parts of chamomile extract, 4-16 parts of centella asiatica extract, 4-16 parts of aloe barbadensis extract, 4-16 parts of sophora flavescens ait root extract, 4-16 parts of hamamelis extract, 4-16 parts of poria cocos sclerotium extract, 4-16 parts of apple fruit extract and 4-16 parts of seabuckthorn fruit extract.
In some preferred embodiments, the weight ratio of the turmeric root extract to the withania extract is 0.1-1: 1 to 5.
Turmeric root: the turmeric is a perennial herb of curcuma of the family of auricularia, has developed and clumped rootstocks, elliptic or cylindrical branches and 8 months of flowering phase, contains various chemical components, and has good medicinal value and economic prospect. Cultivated or wild in plain, inter-mountain grass or shrub. Turmeric roots are generally used in various fields such as medicines and foods as a medicinal part of turmeric.
Nightshade: withania somnifera belongs to the genus Withania of the family Solanales, and grows mostly on hillside with elevation of 750-1000 m, thus having excellent medical value and the like.
The turmeric root is rich in active ingredient turmerone, and can effectively activate a cell free radical defense mechanism, so that the oxidation resistance of the skin is enhanced, and the aging is slowed down; and the turmerone has a very strong activation effect on luciferase, and can inhibit various inflammations of the skin caused by pressure. The Withania somnifera extract can protect skin from DNA damage caused by UV, and relieve stress factors caused by modern life style, thereby improving skin elasticity. The applicant further finds that when the weight ratio of the turmeric root extract to the withania extract is 0.1-1: 1-5, the composition has more excellent effects of wrinkle resistance, skin uniformity and elasticity restoration. The applicant speculates that: the flavonoid component in the Withania Somnifera extract can cooperate with the turmerone component in the turmeric root extract to improve activity, effectively exert the inhibitory effect of the flavonoid component on the ceramidase, and stably maintain the amount of the ceramides in the skin cortex, thereby softening and moistening the skin; on the other hand, the two are compounded and added, so that the skin elastase inhibitor has a strong inhibition effect on skin elastase, has excellent water retention capacity, and effectively inhibits the decomposition of collagen, thereby reducing skin wrinkles, homogenizing skin and improving skin glossiness.
In some preferred embodiments, the weight ratio of ceramide to phytosphingosine is 1-5: 0.05 to 1.2.
The invention provides an essence milk product containing the anti-wrinkle repair composition suitable for the pressure skin, which comprises the following raw materials in parts by weight: 0.1-20 parts of anti-wrinkle repair composition suitable for pressure skin, 0.1-1 part of thickening agent, 0.1-1 part of preservative, 2-5 parts of humectant, 2-5 parts of emulsifier, 10-20 parts of emollient and 48-85.7 parts of water.
In some preferred embodiments, the anti-wrinkle repair composition for pressure skin is 2 to 18 parts.
In some preferred embodiments, the anti-wrinkle repair composition for pressure skin is 4 to 16 parts.
In some preferred embodiments, the humectant is at least one of butylene glycol, sodium hyaluronate, carrageen, trehalose, glycerin.
In some preferred embodiments, the humectant is trehalose and Chondrus crispus; the weight ratio of the trehalose to the carrageen crispa is 2-3: 1 to 2.
The carrageen crispus has a good moisturizing effect, has a good consistency in the preparation process of the composition, and has an obvious inhibiting effect on leukocyte elastase of a human body, and the applicant finds that when the weight ratio of the trehalose to the carrageen crispus is 2-3: 1-2 hours, the carrageen crispa can effectively help skin permeation of beneficial molecules of trehalose, effectively play a role of unique water substitution stress factors of the trehalose, and protect skin cell membranes, so that various skin cell damage and aging problems caused by pressure skin can be effectively resisted.
In some preferred embodiments, the preservative is at least one of 1, 2-hexanediol, p-hydroxyacetophenone.
In some preferred embodiments, the thickener is at least one of carbomer, xanthan gum, hydroxyethyl cellulose.
In some preferred embodiments, the emulsifier is at least one of polyglyceryl-3 methyl glucarate, cetearyl alcohol, hydrogenated lecithin.
In a third aspect, the invention provides a preparation method of the essential milk product containing the anti-wrinkle repair composition suitable for pressure skin, and the preparation method comprises the following steps: (1) adding the emollient and the emulsifier into a proper container, and uniformly stirring and dispersing; (2) heating the antiseptic to 80 deg.C for dissolving and dispersing, adding the rest materials into another container, adding water, and mixing; (3) and (3) uniformly mixing the components (1) and adding the mixture into the container (2), and uniformly stirring and mixing to obtain a finished product.
The turmeric root extract of the present invention may be a commercial turmeric root extract product, such as that sold by the winning industry group.
The withania extract in the invention can be a withania extract product sold in the market, for example, the industrial group winning the creature.
The ceramide in the invention can be products sold in markets, such as ceramide NP, ceramide AP, ceramide EOP and the like sold by the winning industry group.
The phytosphingosine according to the invention can be a commercial product, for example a phytosphingosine product sold by the winning industry group.
The creatine can be commercially available, for example, creatine products sold by the winning industry group.
The Prinsepia utilis oil in the present invention may be commercially available, for example, Prinsepia utilis oil product sold by Lijiang Jinyuan agricultural development Co.
The extract of feverfew of the present invention is commercially available, for example, from Zhenghe (Guangzhou) Biotechnology Ltd.
The centella asiatica extract of the present invention is commercially available, for example, from Zhenghe (Guangzhou) Biotech limited.
The aloe vera extract of the present invention may be commercially available, for example, the aloe vera extract product sold by Zhenghe (Guangzhou) Biotech limited.
The extract of Sophora alopecuroides L in the present invention can be commercially available, for example, the product of Sophora alopecuroides L available from Zhenghe (Guangzhou) Biotech limited.
The Hamamelis virginiana extract of the present invention may be commercially available, for example, from Haematococcus graminis (Guangzhou) Biotech limited.
The apple fruit extract of the present invention is commercially available, for example, apple fruit extract product sold by Zhenghe (Guangzhou) Biotech limited.
The extract of Poria sclerotium in the present invention can be commercially available, for example, Poria sclerotium extract product sold by Zhenghe (Guangzhou) Biotech Co.
The seabuckthorn fruit extract of the present invention is commercially available, for example, from Zhenghe (Guangzhou) Biotech limited.
Examples
The technical solution of the present invention is described in detail by the following examples, but the scope of the present invention is not limited to all of the examples. The starting materials of the present invention are all commercially available unless otherwise specified.
Example 1
In a first aspect, embodiment 1 provides an anti-wrinkle repair composition suitable for pressure skin, which comprises the following raw materials in parts by weight: 15 parts of ceramide, 5 parts of phytosphingosine, 8 parts of turmeric root extract, 16 parts of nightshade extract, 8 parts of creatine, 10 parts of prinsepia utilis royle oil, 16 parts of chamomile extract, 16 parts of centella asiatica extract, 16 parts of aloe barbadensis extract, 16 parts of sophora flavescens root extract, 16 parts of hamamelis virginiana extract, 16 parts of poria cocos sclerotium extract, 16 parts of apple extract and 16 parts of seabuckthorn fruit extract.
Example 1 in a second aspect, there is provided an essential milk product containing the anti-wrinkle repair composition for pressure skin, wherein the raw materials comprise the following components in parts by weight: 10 parts of anti-wrinkle repair composition suitable for pressure skin, 1 part of carbomer, 0.3 part of p-hydroxyacetophenone, 3 parts of humectant (trehalose and carrageen crispa in a weight ratio of 2: 1), 3 parts of polyglycerol-3 methyl glucose distearate, 12 parts of emollient and 85 parts of deionized water.
In a third aspect, the present invention provides a method for preparing the above essential milk product containing the anti-wrinkle repair composition for stressed skin, comprising the following steps: (1) adding 12 parts of emollient and 3 parts of polyglycerol-3 methyl glucose distearate into a container, and uniformly stirring and dispersing; (2) heating 0.3 part of p-hydroxyacetophenone to 80 ℃, dissolving and dispersing uniformly, adding 10 parts of anti-wrinkle repair composition suitable for pressure skin, 1 part of carbomer and 3 parts of humectant (trehalose and carrageen crispa in a weight ratio of 2: 1) into another container, adding 85 parts of deionized water, and mixing uniformly; (3) and (3) uniformly mixing the components (1) and adding the mixture into the container (2), and uniformly stirring and mixing to obtain a finished product.
The turmeric root extract in the embodiment is a turmeric root extract product sold by Yingchuang industry group.
The Withania somnifera extract in the embodiment is a Withania somnifera extract product sold by winning and creating industrial groups.
The ceramide in the embodiment is a ceramide NP product sold by the winning industry group.
The phytosphingosine in the embodiment is a phytosphingosine product sold by the winning industry group.
In the embodiment, the creatine is a creatine product sold by the winning and creating industry group.
The Prinsepia utilis Royle oil in this embodiment can be commercially available, for example, Prinsepia utilis Royle oil product sold by Lijiang Jinyuan agricultural development Co.
In this embodiment, the extract of feverfew may be commercially available, for example, the extract of feverfew sold by Zhenghe (Guangzhou) Biotech limited.
The centella asiatica extract in this embodiment is commercially available, for example, from Zhenghe (Guangzhou) Biotech limited.
The aloe vera extract in this embodiment may be commercially available, for example, the aloe vera extract product sold by Zhenghe (Guangzhou) Biotech limited.
The extract of Sophora alopecuroides L in this embodiment can be commercially available, such as the Sophora alopecuroides L product sold by Poa grass (Guangzhou) Biotech Co.
The Hamamelis virginiana extract in this embodiment may be commercially available, for example, from Yonghe (Guangzhou) Biotech, Inc. for the Hamamelis virginiana extract product.
The apple fruit extract in this embodiment is commercially available, for example, from Zhenghe (Guangzhou) Biotech limited.
In this embodiment, the extract of Poria sclerotium is commercially available, such as that sold by Zhenghe Biotech limited.
The extract of hippophae rhamnoides fruit in this embodiment is commercially available, for example, from Zhenghe (Guangzhou) Biotech limited.
The essential milk product produced in this example was designated as Z1.
Example 2
The embodiment of the present invention is different from embodiment 1 in that: the Withania somnifera extract is 12 parts.
The composition obtained in this example was designated as Z2.
Example 3
The embodiment of the present invention is different from embodiment 1 in that: the humectant is 4 parts, and the weight ratio of the trehalose to the carrageen crispa is 3: 1.
the composition obtained in this example was designated as Z3.
Comparative example 1
The embodiment of this comparative example is the same as example 1 except that: 20 parts of turmeric root extract and 1 part of withania extract.
The composition produced in this comparative example was designated as D1.
Comparative example 2
The embodiment of this comparative example is the same as example 1 except that: 1 part of turmeric root extract and 20 parts of withania extract.
The composition produced in this comparative example was designated as D2.
Comparative example 3
The embodiment of this comparative example is the same as example 1 except that: the humectant is 6 parts, and the weight ratio of the trehalose to the carrageen is 5: 1.
the composition produced in this comparative example was designated as D3.
Comparative example 4
The embodiment of this comparative example is the same as example 1 except that: the humectant is 6 parts, and the weight ratio of the trehalose to the carrageen crispa is 1: 5.
the composition produced in this comparative example was designated as D4.
Comparative example 5
The embodiment of this comparative example is the same as example 1 except that: ceramide is 3 parts.
The composition produced in this comparative example was designated as D5.
Evaluation of Performance
1. The synthesis of collagen of the essence milk product: (1) test samples: all the essence milk products prepared in the examples and the comparative examples are mixed and diluted into a test solution with the mass fraction of 1 wt% by pure water; (2) the test method comprises the following steps: the method comprises the steps of determining the content of collagen I in fibroblasts by an enzyme-linked immunosorbent assay, transferring the fibroblasts into a 96-well culture plate after being digested by trypsin, filling the marginal holes with a sterile phosphate buffer solution, transferring the cells into an incubator to be continuously cultured, sequentially adding 30 mu L/hole of sample solutions of examples and comparative examples by using a microsyringe when the cells are completely attached to the wall and grow, determining the content of the collagen I according to the instruction of a kit after adding the samples for 48 hours, taking 5 multiple holes in each group, taking a common essence milk product without the samples of the examples and the comparative examples on the market as a control group, wherein the collagen synthesis amount is 100%, and taking an average value of test results and recording the average value in table 1.
2. The antioxidant effect of the essence milk product is as follows: (1) test samples:all the essence milk products prepared in the examples and the comparative examples are mixed and diluted into a test solution with the mass fraction of 1 wt% by pure water; (2) the test method comprises the following steps: hydroxyl radical scavenging experiments: taking 0.5mL of absolute ethanol solution of o-diazaphenanthrene with the concentration of 0.75mmol/L into a test tube with a plug, respectively adding 2mL and 1mL of phosphate buffer solution with the pH value of 7.4 and the concentration of 0.2mol/L into the test tube, fully and uniformly mixing the test samples, adding 0.5mL of FeSO with the concentration of 0.75mmol/L into the test tube4·7H2O solution, mixed again and then added with 0.5mL of 0.01% (v/v) H2O2After being put in a constant-temperature water bath at 37 ℃ for 60min, the absorbance values of all groups of mixed solutions are respectively measured at 536nm and recorded As As, the absorbance values are measured by using distilled water instead of sample solution As a blank group and recorded As Ab, and the distilled water instead of H2O2And measuring the absorbance value An of the damage group, and calculating the hydroxyl radical clearance of the test sample according to the following formula: hydroxyl radical clearance (%) [ (As-An)/(Ab-An)]X 100%, the test results are averaged over 5 tests and reported in table 1.
3. And (3) evaluating the product effectiveness: the effectiveness of the serum milk products prepared in all the examples and comparative examples was evaluated. (1) Arranging 8 groups of volunteers, wherein 10 persons in each group have related diseases of pressure skin; (2) the using method comprises the following steps: taking a proper amount of essence milk, uniformly coating the essence milk on the face, slightly pressing for 3-5 minutes for 2 times every morning and evening, and continuously trying all volunteers for 10 weeks while keeping good work and rest during use; (3) the evaluation method comprises the following steps: the condition of facial skin is observed once a week, when the skin state of more than 6 volunteers in the experimental group is obviously improved, the face has no obvious wrinkles and inflammations, the skin has luster and elasticity and is effective as an essence milk product, the effective period is recorded, and the specific results are recorded in table 1.
TABLE 1
Figure BDA0002940972260000141
Figure BDA0002940972260000151
According to the anti-wrinkle repair composition suitable for pressure skin and the essence milk product thereof, the prepared essence milk product has excellent collagen synthesis promoting effect, oxidation free radical removing efficiency and anti-wrinkle skin care effectiveness, is suitable for being popularized in the field of cosmetics, and has a wide development prospect. Wherein example 1 obtains the best performance index under the conditions of the best raw material weight ratio and the like.
Finally, it should be understood that the above-described embodiments are merely preferred embodiments of the present invention, and not intended to limit the present invention, and any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention should be included in the protection scope of the present invention.

Claims (10)

1. An anti-wrinkle repair composition suitable for pressure skin, which is characterized in that: the raw materials comprise the following components in parts by weight: 0.01-20 parts of ceramide, 0.01-20 parts of phytosphingosine, 0.01-20 parts of creatine, 0.01-20 parts of prinsepia utilis royle oil and 0.1-200 parts of plant extract.
2. The anti-wrinkle repair composition for stressed skin according to claim 1, wherein: the plant extract comprises the following components in parts by weight: 0.01-20 parts of turmeric root extract, 0.01-20 parts of nightshade extract, 0.01-20 parts of white flower chamomile extract, 0.01-20 parts of centella extract, 0.01-20 parts of aloe barbadensis extract, 0.01-20 parts of sophora flavescens root extract, 0.01-20 parts of hamamelis extract, 0.01-20 parts of poria cocos sclerotium extract, 0.01-20 parts of apple extract and 0.01-20 parts of seabuckthorn fruit extract.
3. The anti-wrinkle repair composition for stressed skin according to claim 2, wherein: the weight ratio of the turmeric root extract to the Withania Somnifera extract is 0.1-1: 1 to 5.
4. The anti-wrinkle repair composition for stressed skin according to claim 2, wherein: the weight ratio of ceramide to phytosphingosine is 1-5: 0.05 to 1.2.
5. An essence cream comprising the anti-wrinkle repair composition for pressure skin according to any one of claims 1 to 4, characterized in that: the raw materials comprise the following components in parts by weight: 0.1-20 parts of anti-wrinkle repair composition suitable for pressure skin, 0.1-1 part of thickening agent, 0.1-1 part of preservative, 2-5 parts of humectant, 2-5 parts of emulsifier, 10-20 parts of emollient and 48-85.7 parts of water.
6. The essential milk product comprising an anti-wrinkle repair composition for pressure skin according to claim 5, characterized in that: the humectant is at least one of butanediol, sodium hyaluronate, Chondrus crispus, trehalose, and glycerol.
7. The essential milk product comprising an anti-wrinkle repair composition for pressure skin according to claim 6, characterized in that: the humectant is trehalose and Chondrus crispus; the weight ratio of the trehalose to the carrageen crispa is 2-3: 1 to 2.
8. The essential milk product comprising an anti-wrinkle repair composition for pressure skin according to claim 5, characterized in that: the thickener is at least one of carbomer, xanthan gum and hydroxyethyl cellulose.
9. The essential milk product comprising an anti-wrinkle repair composition for pressure skin according to claim 5, characterized in that: the emulsifier is at least one of polyglycerol-3 methyl glucose distearate, cetearyl alcohol and hydrogenated lecithin.
10. A method for preparing an essential milk product containing an anti-wrinkle repair composition suitable for pressure skin according to any one of claims 5 to 9, characterized in that: the method comprises the following steps: (1) adding the emollient and the emulsifier into a proper container, and uniformly stirring and dispersing; (2) heating the antiseptic to 80 deg.C for dissolving and dispersing, adding the rest materials into another container, adding water, and mixing; (3) and (3) uniformly mixing the components (1) and adding the mixture into the container (2), and uniformly stirring and mixing to obtain a finished product.
CN202110179277.5A 2021-02-07 2021-02-07 Anti-wrinkle repair composition suitable for pressure skin and essence emulsion product thereof Pending CN112999131A (en)

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