CN112972756A - Recombinant keratin liquid bandage and preparation method thereof - Google Patents
Recombinant keratin liquid bandage and preparation method thereof Download PDFInfo
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- CN112972756A CN112972756A CN202110219229.4A CN202110219229A CN112972756A CN 112972756 A CN112972756 A CN 112972756A CN 202110219229 A CN202110219229 A CN 202110219229A CN 112972756 A CN112972756 A CN 112972756A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
- A61L26/0028—Polypeptides; Proteins; Degradation products thereof
- A61L26/0047—Specific proteins or polypeptides not covered by groups A61L26/0033 - A61L26/0042
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0004—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing inorganic materials
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
- A61L26/0014—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
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Abstract
The invention relates to a recombinant keratin liquid bandage which comprises, by mass, 20-30 parts of a recombinant keratin solution, 40-50 parts of an organic solvent, 18-32 parts of a high-molecular film-forming agent, 15-25 parts of aluminum powder and 8-14 parts of white mineral oil. After the liquid bandage provided by the invention is sprayed out, a layer of uniform polymer protective film can be formed on the wound surface, the liquid bandage can be well attached to the wound surface, a compact physical barrier is formed, and the wound surface is protected from being invaded by bacteria and microorganisms. The formed protective film has good water resistance and air permeability, and the recombinant keratin can promote the migration and proliferation of cells and accelerate the healing of wound surfaces. The liquid bandage can keep the wettability of wound healing, avoid secondary injury of the wound caused by easy-drying scabbing of the wound, and has better stability and practicability.
Description
Technical Field
The invention relates to the technical field of liquid bandages, in particular to a recombinant keratin liquid bandage and a preparation method thereof.
Background
No matter the degree of injury of skin wounds, the wounds can cause the destruction of electrolyte balance in vivo, if the wounds cannot heal in time, external bacteria invasion can be caused, so that the wound healing speed is low due to wound infection, and the wound infection even can cause severe blood diseases such as septicemia and the like; therefore, various medical liquid bandages for wound surfaces and wounds appear at home and abroad at present; the liquid bandage is a substance composed of a film material and a solvent, and is sprayed on the skin surface of a wound to heal the wound, but the wound liquid bandages on the market at present have some defects: 1) the existing liquid bandage cannot be well attached to the skin of a wound surface, the surface of the damaged skin is easily exposed in the air, the effect of quickly healing the wound cannot be achieved, and the wound is easily infected by external bacteria; 2) the existing liquid bandage is easy to cause that the wound part is easy to dry and scab under the dry condition for a long time, so that secondary mechanical injury is caused to the wound when the liquid bandage is removed; 3) the existing liquid bandage can not well absorb the exudate of a wound surface, and easily causes the injuries of whitening, sensitization and the like of the wound; 4) the existing liquid bandage has poor waterproof and moisture-permeable performance and cannot provide good moist and breathable environment for wound recovery; 5) the existing liquid bandage has complex processing technology and poor stability and usability of the product.
Disclosure of Invention
Aiming at the defects in the prior art, the invention provides a recombinant keratin liquid bandage and a preparation method thereof, and solves the technical problems that the existing liquid bandage cannot be well attached to a wound surface, secondary mechanical injury is caused when the liquid bandage is easily removed, the water resistance and the moisture permeability are complex, the processing technology is complex, the product stability is poor, and the like.
In order to achieve the aim, the invention provides a recombinant keratin liquid bandage which comprises, by mass, 20-30 parts of a recombinant keratin solution, 40-50 parts of an organic solvent, 18-32 parts of a high-molecular film-forming agent, 15-25 parts of aluminum powder and 8-14 parts of white mineral oil.
Preferably, the cosmetic comprises 24-26 parts of a recombinant keratin solution, 42-48 parts of an organic solvent, 20-30 parts of a high-molecular film forming agent, 18-22 parts of aluminum powder and 10-12 parts of white mineral oil.
Preferably, the recombinant keratin solution comprises a recombinant keratin stock solution, a stabilizer, a bacteriostatic agent and deionized water.
Preferably, the recombinant keratin solution comprises 10-20% of recombinant keratin stock solution, 14-20% of stabilizing agent, 0.1-0.5% of bacteriostatic agent and the balance of deionized water by mass percentage. This allows the stability and shelf life of the recombinant keratin solution to be increased and the production of a stable system of recombinant keratin solution avoids the effect of other added substances in the liquid bandage on the recombinant keratin.
Preferably, the organic solvent is ethyl acetate or a mixed solution of ethyl acetate and absolute ethyl alcohol. Therefore, the high-molecular film forming agent has good solubility, is volatilized fast when being sprayed on the skin, is convenient and fast to form a film and isolate a wound, and has good safety.
Preferably, the organic solvent comprises 85-90% of ethyl acetate and 10-15% of absolute ethyl alcohol by mass percentage. Make polymer film-forming agent dissolve faster like this, the film forming is faster, also can disinfect to the wound, avoids the wound to be infected to a small amount of absolute ethyl alcohol can let the water film of reorganization keratin solution break when the film forming, makes the reorganization keratin can be to the faster performance of wound, makes the healing effect of wound better.
Preferably, the macromolecular film forming agent is polyacrylate. The film formed by the liquid bandage at the wound has good waterproofness, is tightly attached to the skin and is not easy to fall off, even the formed film has good toughness, the situation that the film is not attached due to the movement of the joint of the wound at the joint can be avoided, and the peeling of the film can not be caused when people carelessly flex the film when the wound is itchy.
Preferably, the stabilizer comprises glycerol, NaCl and sucrose, and the mass ratio of the glycerol to the NaCl to the sucrose is 4: 1: 2. therefore, the stability of the solution system formed by the recombinant keratin is good, the activity of the recombinant keratin is kept for a longer time, and the wound hemostasis and healing effects of the liquid bandage are better.
Preferably, the bacteriostatic agent is sodium azide. This ensures sterility of the recombinant keratin, making the liquid bandage safer.
A process for the preparation of a recombinant keratin liquid bandage as claimed in claims 1 to 9, comprising the following steps:
1) adding the extracted recombinant keratin into deionized water, continuously stirring for 20-30 min, adding a stabilizer and a bacteriostatic agent, and continuously stirring until the mixture is uniform to obtain a recombinant keratin solution;
2) adding a high-molecular film-forming agent into an organic solvent, stirring at a high speed for 60-80 min, gradually adding aluminum powder and white mineral oil while stirring, and stirring until the aluminum powder and the white mineral oil are uniformly mixed to obtain a mixed liquid;
3) adding the recombinant keratin solution into the mixed liquid obtained in the step 2), and performing ultrasonic treatment for 10-20 min to obtain a recombinant keratin liquid bandage;
4) the recombinant keratin liquid bandage was filled into a high pressure nebulizer, which used butane as the propellant.
Compared with the prior art, the invention has the beneficial effects that:
1) the invention provides a recombinant keratin liquid bandage and a preparation method thereof, the recombinant keratin is mixed with deionized water to quickly absorb water and swell, and then a stabilizing agent and a bacteriostatic agent are added to prepare a recombinant keratin solution; then the liquid bandage is prepared by ultrasonic mixing with organic solvent, macromolecule film-forming agent and the like, and finally the liquid bandage is filled into a high-pressure sprayer; therefore, when a wound appears, the liquid bandage is sprayed on the wound by pressing the sprayer to quickly cover the wound, the recombinant keratin solution is contacted with the wound to promote mitosis and migration of epidermal cells, promote proliferation and growth of cells, quickly stop bleeding with the wound and promote wound healing, and experiments prove that new granulation can be obviously seen on the wound after 1-2 weeks of the application of the invention according to different depths of the wound; the organic solvent can volatilize fast on the skin surface for polymer film-forming agent, aluminium powder and white mineral oil can form the protection film of laminating completely with skin fast in the wound, make isolated with wound and external environment, avoid external bacterium to cause the infection.
2) According to the invention, as the recombinant keratin adsorbs a large amount of deionized water to prepare the recombinant keratin solution, the water in the recombinant keratin solution can be slowly leached out when the recombinant keratin promotes the growth of the wound, so that the wound is kept in a relatively moist state for a long time, on one hand, the wound is convenient to heal, more importantly, the situation that the wound is easy to dry and scab is avoided, and the secondary damage to the wound when the liquid bandage is removed is avoided.
3) The protective film formed in the liquid bandage has good air permeability and water resistance, can absorb wound exudate, avoids injury such as whitening and sensitization of wounds, can provide a good moist and air-permeable environment for the wounds, enables the healing effect of the wounds to be better, and is beneficial to reducing the situation of scars left after the wounds heal.
4) The preparation method of the liquid bandage provided by the invention is simple, and the product has good stability, so that the recombinant keratin can stably promote wound healing, and the effect and usability of the product are better.
Detailed Description
Hereinafter, embodiments of the present invention will be described in detail. The following examples are only for illustrating the technical solutions of the present invention more clearly, and therefore are only examples, and the protection scope of the present invention is not limited thereby.
It is to be noted that, unless otherwise specified, technical or scientific terms used herein shall have the ordinary meaning as understood by those skilled in the art to which the invention pertains.
Reference herein to "an embodiment" means that a particular feature, structure, or characteristic described in connection with the embodiment can be included in at least one embodiment of the invention. The appearances of the phrase in various places in the specification are not necessarily all referring to the same embodiment, nor are separate or alternative embodiments mutually exclusive of other embodiments. It is explicitly and implicitly understood by one skilled in the art that the embodiments described herein can be combined with other embodiments.
The recombinant keratin stock solution in the present invention refers to the recombinant keratin extract stock solution disclosed in patent No. 201810123711.6.
Example 1
A recombinant keratin liquid bandage comprises, by mass, 3 parts of a recombinant keratin stock solution, 2 parts of glycerol, 0.5 part of NaCl0.5 part of sucrose, 0.1 part of sodium azide, 13.4 parts of deionized water, 40 parts of ethyl acetate, 18 parts of polyacrylate, 15 parts of aluminum powder and 8 parts of white mineral oil.
A method for preparing a recombinant keratin liquid bandage, which is characterized by comprising the following steps:
1) adding the extracted recombinant keratin stock solution into deionized water, continuously stirring for 20min, adding a stabilizer and a bacteriostatic agent, and continuously stirring until the mixture is uniform to obtain a recombinant keratin solution;
2) adding a high-molecular film-forming agent into an organic solvent, stirring at a high speed for 60min, gradually adding aluminum powder and white mineral oil while stirring, and stirring until the aluminum powder and the white mineral oil are uniformly mixed to obtain a mixed liquid;
3) adding the recombinant keratin solution into the mixed liquid obtained in the step 2), and performing ultrasonic treatment for 10min to obtain a recombinant keratin liquid bandage;
4) the recombinant keratin liquid bandage was filled into a high pressure nebulizer, which used butane as the propellant.
Example 2
A recombinant keratin liquid bandage comprises, by mass, 4 parts of a recombinant keratin stock solution, 2.6 parts of glycerol, 0.6 part of NaCl0.6 part of NaCl0.3 part of sucrose, 0.1 part of sodium azide, 15.4 parts of deionized water, 37 parts of ethyl acetate, 5 parts of absolute ethyl alcohol, 20 parts of polyacrylate, 18 parts of aluminum powder and 10 parts of white mineral oil.
A method for preparing a recombinant keratin liquid bandage, which is characterized by comprising the following steps:
1) adding the extracted recombinant keratin stock solution into deionized water, continuously stirring for 22min, adding a stabilizer and a bacteriostatic agent, and continuously stirring until the mixture is uniform to obtain a recombinant keratin solution;
2) adding a high-molecular film-forming agent into an organic solvent, stirring at a high speed for 65min, gradually adding aluminum powder and white mineral oil while stirring, and stirring until the aluminum powder and the white mineral oil are uniformly mixed to obtain a mixed liquid;
3) adding the recombinant keratin solution into the mixed liquid obtained in the step 2), and performing ultrasonic treatment for 12min to obtain a recombinant keratin liquid bandage;
4) the recombinant keratin liquid bandage was filled into a high pressure nebulizer, which used butane as the propellant.
Example 3
A recombinant keratin liquid bandage comprises, by mass, 4.4 parts of a recombinant keratin stock solution, 2.8 parts of glycerol, 0.7 part of NaCl0.7 part of sucrose, 0.1 part of sodium azide, 15.6 parts of deionized water, 39 parts of ethyl acetate, 6 parts of absolute ethyl alcohol, 25 parts of polyacrylate, 20 parts of aluminum powder and 11 parts of white mineral oil.
A method for preparing a recombinant keratin liquid bandage, which is characterized by comprising the following steps:
1) adding the extracted recombinant keratin stock solution into deionized water, continuously stirring for 25min, adding the stabilizer and the bacteriostatic agent, and continuously stirring until the mixture is uniform to obtain a recombinant keratin solution;
2) adding a high-molecular film-forming agent into an organic solvent, stirring at a high speed for 70min, gradually adding aluminum powder and white mineral oil while stirring, and stirring until the aluminum powder and the white mineral oil are uniformly mixed to obtain a mixed liquid;
3) adding the recombinant keratin solution into the mixed liquid obtained in the step 2), and performing ultrasonic treatment for 15min to obtain a recombinant keratin liquid bandage;
4) the recombinant keratin liquid bandage was filled into a high pressure nebulizer, which used butane as the propellant.
Example 4
A recombinant keratin liquid bandage comprises, by mass, 4.8 parts of a recombinant keratin stock solution, 2.9 parts of glycerol, 0.7 part of NaCl0.5 part of sucrose, 0.1 part of sodium azide, 16 parts of deionized water, 40 parts of ethyl acetate, 8 parts of absolute ethyl alcohol, 30 parts of polyacrylate, 22 parts of aluminum powder and 12 parts of white mineral oil.
A method for preparing a recombinant keratin liquid bandage, which is characterized by comprising the following steps:
1) adding the extracted recombinant keratin stock solution into deionized water, continuously stirring for 28min, adding the stabilizer and the bacteriostatic agent, and continuously stirring until the mixture is uniform to obtain a recombinant keratin solution;
2) adding a high-molecular film-forming agent into an organic solvent, stirring at a high speed for 75min, gradually adding aluminum powder and white mineral oil while stirring, and stirring until the aluminum powder and the white mineral oil are uniformly mixed to obtain a mixed liquid;
3) adding the recombinant keratin solution into the mixed liquid obtained in the step 2), and performing ultrasonic treatment for 18min to obtain a recombinant keratin liquid bandage;
4) the recombinant keratin liquid bandage was filled into a high pressure nebulizer, which used butane as the propellant.
Example 5
A recombinant keratin liquid bandage comprises, by mass, 5 parts of a recombinant keratin stock solution, 3.1 parts of glycerol, 0.8 part of NaCl0.8 part of sucrose, 0.1 part of sodium azide, 19.5 parts of deionized water, 41 parts of ethyl acetate, 9 parts of absolute ethyl alcohol, 32 parts of polyacrylate, 25 parts of aluminum powder and 14 parts of white mineral oil.
A method for preparing a recombinant keratin liquid bandage, which is characterized by comprising the following steps:
1) adding the extracted recombinant keratin stock solution into deionized water, continuously stirring for 30min, adding a stabilizer and a bacteriostatic agent, and continuously stirring until the mixture is uniform to obtain a recombinant keratin solution;
2) adding a high-molecular film-forming agent into an organic solvent, stirring at a high speed for 80min, gradually adding aluminum powder and white mineral oil while stirring, and stirring until the aluminum powder and the white mineral oil are uniformly mixed to obtain a mixed liquid;
3) adding the recombinant keratin solution into the mixed liquid obtained in the step 2), and performing ultrasonic treatment for 20min to obtain a recombinant keratin liquid bandage;
4) the recombinant keratin liquid bandage was filled into a high pressure nebulizer, which used butane as the propellant.
Preparing liquid bandage samples 1-5 according to the formula and the preparation method of the examples 1-5, then spraying the liquid bandage on the wounds of different patients, wherein the samples 1-5 form a protective film after being sprayed out from the wounds for 10-20s, and the film forming speed of the sample 3 is the fastest; continuously observing the growth condition of the wound, and observing the granulation tissue growing on the wound of the sprayed sample 1-5 by naked eyes within 5-10 days, wherein the new granulation tissue is observed on the wound of the sprayed sample 3 within 5 days; the wound surface grows well, the wound does not have the situations of whitening and the like, the integrity of the protective film is good, the liquid bandage is cleaned after the wound grows well, the wound healing condition is good, the wound healing is smooth, and the formation of scars can be reduced; in conclusion, the liquid bandage provided by the invention can promote wound hemostasis and healing acceleration.
Finally, it should be noted that: the above embodiments are only used to illustrate the technical solution of the present invention, and not to limit the same; while the invention has been described in detail and with reference to the foregoing embodiments, it will be understood by those skilled in the art that: the technical solutions described in the foregoing embodiments may still be modified, or some or all of the technical features may be equivalently replaced; such modifications and substitutions do not depart from the spirit and scope of the present invention, and they should be construed as being included in the following claims and description.
Claims (10)
1. The recombinant keratin liquid bandage is characterized by comprising 20-30 parts of recombinant keratin solution, 40-50 parts of organic solvent, 18-32 parts of polymer film-forming agent, 15-25 parts of aluminum powder and 8-14 parts of white mineral oil in parts by weight.
2. The recombinant keratin liquid bandage of claim 1, comprising 24-26 parts of a recombinant keratin solution, 42-48 parts of an organic solvent, 20-30 parts of a high-molecular film-forming agent, 18-22 parts of aluminum powder and 10-12 parts of white mineral oil.
3. The recombinant keratin liquid bandage of claim 1 or 2, wherein the recombinant keratin solution comprises a recombinant keratin stock solution, a stabilizer, a bacteriostatic agent and deionized water.
4. The recombinant keratin liquid bandage of claim 3, wherein the recombinant keratin solution comprises, in mass fraction, 10% -20% of recombinant keratin stock solution, 14% -20% of stabilizing agent, 0.1% -0.5% of bacteriostatic agent, and the balance being deionized water.
5. The recombinant keratin liquid bandage of claim 1, wherein the organic solvent is ethyl acetate or a mixed solution of ethyl acetate and absolute ethanol.
6. The recombinant keratin liquid bandage of claim 5, wherein the organic solvent comprises, in mass percent, from 85% to 90% ethyl acetate and from 10% to 15% absolute ethanol.
7. The recombinant keratin liquid bandage of claim 1, wherein the polymeric film-forming agent is a polyacrylate.
8. The recombinant keratin liquid bandage of claim 3, wherein the stabilizing agent comprises glycerol, NaCl, and sucrose in a mass ratio of 4: 1: 2.
9. the recombinant keratin liquid bandage of claim 3, wherein the bacteriostatic agent is sodium azide.
10. Process for the preparation of a recombinant keratin liquid bandage according to claims 1 to 9, comprising the following steps:
1) adding the extracted recombinant keratin stock solution into deionized water, continuously stirring for 20-30 min, adding a stabilizer and a bacteriostatic agent, and continuously stirring until the mixture is uniform to obtain a recombinant keratin solution;
2) adding a high-molecular film-forming agent into an organic solvent, stirring at a high speed for 60-80 min, gradually adding aluminum powder and white mineral oil while stirring, and stirring until the aluminum powder and the white mineral oil are uniformly mixed to obtain a mixed liquid;
3) adding the recombinant keratin solution into the mixed liquid obtained in the step 2), and performing ultrasonic treatment for 10-20 min to obtain a recombinant keratin liquid bandage;
4) the recombinant keratin liquid bandage was filled into a high pressure nebulizer, which used butane as the propellant.
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| CN202110219229.4A CN112972756A (en) | 2021-02-26 | 2021-02-26 | Recombinant keratin liquid bandage and preparation method thereof |
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| CN202110219229.4A CN112972756A (en) | 2021-02-26 | 2021-02-26 | Recombinant keratin liquid bandage and preparation method thereof |
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE805671C (en) * | 1949-11-15 | 1951-05-25 | Paul Hartmann A G | Wound dressing |
| US5792469A (en) * | 1992-03-12 | 1998-08-11 | Atrix Laboratories, Inc. | Biodegradable in situ forming film dressing |
| CN1399565A (en) * | 1999-11-23 | 2003-02-26 | 永动力控股公司 | Propellant free spray-on skin patch composition for improving wound healing and for drug administration |
| EP2926781A1 (en) * | 2014-04-01 | 2015-10-07 | Paul Hartmann AG | Dressing set for negative pressure therapy |
| CN112156224A (en) * | 2020-01-20 | 2021-01-01 | 海南海默斯医学生物科技有限公司 | Composition for preparing keratin liquid dressing and preparation method and application thereof |
-
2021
- 2021-02-26 CN CN202110219229.4A patent/CN112972756A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE805671C (en) * | 1949-11-15 | 1951-05-25 | Paul Hartmann A G | Wound dressing |
| US5792469A (en) * | 1992-03-12 | 1998-08-11 | Atrix Laboratories, Inc. | Biodegradable in situ forming film dressing |
| CN1399565A (en) * | 1999-11-23 | 2003-02-26 | 永动力控股公司 | Propellant free spray-on skin patch composition for improving wound healing and for drug administration |
| EP2926781A1 (en) * | 2014-04-01 | 2015-10-07 | Paul Hartmann AG | Dressing set for negative pressure therapy |
| CN112156224A (en) * | 2020-01-20 | 2021-01-01 | 海南海默斯医学生物科技有限公司 | Composition for preparing keratin liquid dressing and preparation method and application thereof |
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