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CN112945833A - Measure cerini dialyser cerini hollow fiber membrane water flux tester - Google Patents

Measure cerini dialyser cerini hollow fiber membrane water flux tester Download PDF

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Publication number
CN112945833A
CN112945833A CN202110240869.3A CN202110240869A CN112945833A CN 112945833 A CN112945833 A CN 112945833A CN 202110240869 A CN202110240869 A CN 202110240869A CN 112945833 A CN112945833 A CN 112945833A
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CN
China
Prior art keywords
frame body
dialyzer
hollow fiber
fiber membrane
tester
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Pending
Application number
CN202110240869.3A
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Chinese (zh)
Inventor
廖磊
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Bain Medical Equipment Guangzhou Co ltd
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Bain Medical Equipment Guangzhou Co ltd
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Priority to CN202110240869.3A priority Critical patent/CN112945833A/en
Publication of CN112945833A publication Critical patent/CN112945833A/en
Pending legal-status Critical Current

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    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/08Investigating permeability, pore-volume, or surface area of porous materials
    • G01N15/088Investigating volume, surface area, size or distribution of pores; Porosimetry
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/08Investigating permeability, pore-volume, or surface area of porous materials
    • G01N15/0806Details, e.g. sample holders, mounting samples for testing

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  • Chemical & Material Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • External Artificial Organs (AREA)

Abstract

The invention discloses a tester for measuring the water flux of a hollow fiber membrane of a dialyzer, which adopts the technical scheme that: the dialysis device comprises a frame body, peristaltic pumps are fixedly mounted on two sides of the frame body, a plurality of pressure meters are fixedly arranged at the top of the frame body respectively, one ends of the pressure meters extend into the frame body, pressure meter mounting seats are fixedly arranged at the bottoms of the pressure meters, and a dialysis mechanism is arranged on the front side of the frame body; the dialysis mechanism comprises a first dialyzer and a second dialyzer, and the dialysis mechanism has the advantages that: the peristaltic pump is controlled to start and stop through the starting button, the peristaltic pump is a fixed displacement pump, after the working time and the water outlet flow at each time are set, the two stations on the left and right of the whole machine can realize simultaneous measurement, the two stations are mutually independent and do not interfere with each other, the working efficiency is improved, the result feedback time is shortened, the performance feedback of high-efficiency products required by a production site is sufficient, the requirement of an operator is small, the operation is convenient and fast, and the cost is reduced.

Description

Measure cerini dialyser cerini hollow fiber membrane water flux tester
Technical Field
The invention relates to the field of preparation of hollow fiber membranes of dialyzers, in particular to a tester for measuring water flux of hollow fiber membranes of dialyzers.
Background
The dialyzer is commonly called artificial kidney and has been widely used clinically. By performing hemodialysis, the life of a patient can be appropriately extended. The dialyzer generally comprises a shell, hollow fibers, also called Dialysis membrane, arranged in the shell, a blood inlet pipe, a blood outlet pipe, a dialysate inlet pipe and a dialysate outlet pipe which are arranged at two ends of the shell, wherein the hemodialysis (Dialysis) introduces the blood of a patient and the dialysate into the dialyzer at the same time by utilizing the principle of a semipermeable membrane, the two dialyzers flow in opposite directions at two sides of the Dialysis membrane, and by means of solute gradient, osmotic gradient and water pressure gradient at two sides of the membrane, so as to achieve the purposes of eliminating toxin and excessive water retention in the body, simultaneously supplementing substances required in the body and maintaining the balance of electrolyte and acid-base, the ultrafiltration rate of the dialysis membrane can be measured by simulating the method of using a dialyzer clinically to qualitatively judge the water removing capacity of the dialysis membrane, namely, the water yield of the high-pass dialysis membrane and the low-pass dialysis membrane is measured under the condition of certain transmembrane pressure and flow.
The prior art has the following defects: the existing measuring method is to analyze the pore size and porosity of the dialysis membrane under a quadratic element instrument in a laboratory for judgment, the method has low efficiency, generally requires one to two days to obtain result feedback, has insufficient feedback on the performance of high-efficiency products required by a production field, has large requirements on personnel operating the instrument, and can only operate one dialysis membrane by each person at most.
Therefore, it is necessary to invent a water flux tester for the hollow fiber membrane of the dialyzer.
Disclosure of Invention
Therefore, the invention provides a tester for measuring the water flux of a hollow fiber membrane of a dialyzer, wherein the start-up and stop work of a peristaltic pump is controlled by a start button, the peristaltic pump is a constant delivery pump, and after the working time and the water outlet flow rate of each time are set, the left station and the right station of the whole dialyzer can realize simultaneous measurement which are independent and do not interfere with each other, so that the problems that the result feedback is slow, the performance feedback of high-efficiency products required by a production site is insufficient, the requirement on personnel operating the instrument is large, and at most one dialyzer can be operated by each person are solved.
In order to achieve the above purpose, the invention provides the following technical scheme: a tester for measuring water flux of a hollow fiber membrane of a dialyzer comprises a frame body, peristaltic pumps are fixedly mounted on two sides of the frame body, a plurality of pressure meters are fixedly mounted at the top of the frame body respectively, one ends of the pressure meters extend into the frame body, pressure meter mounting seats are fixedly mounted at the bottoms of the pressure meters, and a dialysis mechanism is arranged on the front side of the frame body;
dialysis mechanism includes first cerini dialyser cerini and second cerini dialyser cerini, frame body front side is all located to first cerini dialyser cerini and second cerini dialyser cerini, first cerini dialyser cerini and second cerini outside cover are equipped with two and mould plastics the support piece respectively, the fixed support piece cushion that is equipped with in support piece one side of moulding plastics, support piece cushion and frame body fixed connection, first cerini dialyser cerini and second cerini dialyser cerini one side are all fixed and are equipped with the push rod guide holder, push rod guide holder and frame body fixed connection, push rod guide holder front side is equipped with the second knob, the inside ejector pin that is equipped with of push rod guide holder, the ejector pin runs through the push rod guide holder, ejector pin one end fixedly connected with polyurethane briquetting, the ejector pin other end is equipped with first knob.
Preferably, a plurality of foot seats are fixedly connected to the bottom of the frame body, and two starting switches are fixedly embedded in the top of the frame body.
Preferably, a first flowmeter and a second flowmeter are respectively and fixedly arranged on the front side of the frame body, the second flowmeter is arranged on the left side of the first flowmeter, a first wire sheath is fixedly arranged on the front side of the frame body, two water outlet throttle valves are fixedly embedded in the front side of the frame body, a back plate is arranged on the rear side of the frame body, and a door handle is arranged on one side of the back plate.
Preferably, the peristaltic pump top is fixed and is equipped with the pump handle, peristaltic pump bottom both sides all are fixed and are equipped with the second foot sign indicating number, both sides the second foot sign indicating number all with frame body fixed connection.
Preferably, the side wall of the interior of the frame body is fixedly provided with a junction box, the two side walls of the interior of the frame body are fixedly connected with damper mounting plates, and the bottoms of the damper mounting plates are fixedly connected with pulse dampers.
Preferably, both sides of the bottom of the inner cavity of the frame body are fixedly provided with second wire protecting sleeves, the frame body is internally provided with a first support and a second support respectively, the first support and the second support are fixed with the frame body through bolts, and the frame body is internally fixedly provided with a first foot code.
Preferably, a second filter and a first filter are respectively fixedly arranged on one side of the first bracket and one side of the second bracket.
The invention has the beneficial effects that:
1. according to the invention, after water is pumped out of the constant-temperature water pool by the peristaltic pump, the water passes through the pulse damper, the first filter and the second filter in the frame body, enters the lower blood ports of the first dialyzer and the second dialyzer through the pressure gauge, and is started and stopped by the starting switch, the peristaltic pump is a constant delivery pump, after the working time and the water outlet flow rate of each time are set, the left station and the right station of the whole machine can realize simultaneous measurement, are independent and do not interfere with each other, the ejector rod is adjusted to move by the first knob, so that polyurethane at one end of the ejector rod supports against the first dialyzer and the second dialyzer, and the ejector rod is fixed by rotating the second knob, the fixture fixing mode is simple, the loading and unloading operation is simple, the product switching is convenient, and the device can be used for various products with different external;
2. according to the invention, the pressure intensity is changed by adjusting the water outlet throttle valve, the performance of high and low pass can be tested, meanwhile, the injection molding support piece and the support piece cushion block have the functions of fixing and supporting the first dialyzer and the second dialyzer, the foot rest has the supporting function, the working efficiency is improved, the result feedback time is shortened, the feedback on the performance of high-efficiency products required by a production site is sufficient, the requirement of operators is small, the operation is convenient and fast, and the cost is reduced.
Drawings
FIG. 1 is a schematic view of the overall structure provided by the present invention;
FIG. 2 is a schematic view of the internal structure of the frame body according to the present invention;
FIG. 3 is a rear perspective view provided by the present invention;
FIG. 4 is a top view provided by the present invention;
FIG. 5 is a side view provided by the present invention;
fig. 6 is an enlarged view of a portion a of fig. 1 according to the present invention.
In the figure: the device comprises a frame body 1, a pressure gauge 2, a starting switch 3, a first dialyzer 4, an injection molding support 5, a water outlet throttle valve 6, a support cushion 7, a first wire protecting sleeve 8, a first flowmeter 9, a pump handle 10, a peristaltic pump 11, a foot seat 12, a pressure gauge mounting seat 13, a first filter 14, a damper mounting plate 15, a pulse damper 16, a junction box 17, a second filter 18, a first foot code 19, a first support 20, a second wire protecting sleeve 21, a second support 22, a rear back plate 23, a door handle 24, a second foot code 25, a push rod guide seat 26, a push rod 27, a first knob 28, a second knob 29, polyurethane 30, a polyurethane pressing block 31, a second flowmeter 32 and a second dialyzer 33.
Detailed Description
The preferred embodiments of the present invention will be described in conjunction with the accompanying drawings, and it will be understood that they are described herein for the purpose of illustration and explanation and not limitation.
Examples
Referring to the attached drawings 1-6, the tester for measuring the water flux of the hollow fiber membrane of the dialyzer comprises a frame body 1, peristaltic pumps 11 are fixedly mounted on two sides of the frame body 1, a plurality of pressure gauges 2 are fixedly mounted at the top of the frame body 1 respectively, one ends of the pressure gauges 2 extend into the frame body 1, pressure gauge mounting seats 13 are fixedly mounted at the bottoms of the pressure gauges 2, and a dialysis mechanism is arranged on the front side of the frame body 1;
the dialysis mechanism comprises a first dialyzer 4 and a second dialyzer 33, wherein the first dialyzer 4 and the second dialyzer 33 are both arranged on the front side of a frame body 1, two injection-molded supporting pieces 5 are respectively sleeved outside the first dialyzer 4 and the second dialyzer 33, a supporting piece cushion block 7 is fixedly arranged on one side of each injection-molded supporting piece 5, the supporting piece cushion block 7 is fixedly connected with the frame body 1, a push rod guide seat 26 is fixedly arranged on one side of each of the first dialyzer 4 and the second dialyzer 33, the push rod guide seat 26 is fixedly connected with the frame body 1, a second knob 29 is arranged on the front side of the push rod guide seat 26, an ejector rod 27 is arranged inside the push rod guide seat 26, the ejector rod 27 penetrates through the push rod guide seat 26, one end of the ejector rod 27 is fixedly connected with a polyurethane pressing block 31, the other end of the ejector rod 27 is provided with a first knob 28, one side of the polyurethane pressing block 31 is fixedly provided, the pressure gauge 2 can observe the water flow pressure of the inlet water and the outlet water, and the first dialyzer 4 and the second dialyzer 33 have a dialysis function.
Further, a plurality of foot seats 12 are fixedly connected to the bottom of the frame body 1, two starting switches 3 are fixedly embedded in the top of the frame body 1, and the foot seats 12 have a supporting function.
Furthermore, a first flowmeter 9 and a second flowmeter 32 are respectively and fixedly arranged on the front side of the frame body 1, the second flowmeter 32 is arranged on the left side of the first flowmeter 9, a first wire sheath 8 is fixedly arranged on the front side of the frame body 1, two water outlet throttle valves 6 are fixedly embedded on the front side of the frame body 1, a back plate 23 is arranged on the rear side of the frame body 1, a door handle 24 is arranged on one side of the back plate 23, and the first flowmeter 9 and the second flowmeter 32 can detect the water flow.
Further, 11 fixed pump handles 10 that are equipped with in top of peristaltic pump, 11 bottom both sides of peristaltic pump all are fixed and are equipped with second foot sign indicating number 25, both sides second foot sign indicating number 25 all with frame body 1 fixed connection, pump handles 10 conveniently open.
Further, a junction box 17 is fixedly mounted on the inner side wall of the frame body 1, damper mounting plates 15 are fixedly connected to the inner side wall of the frame body 1, pulse dampers 16 are fixedly connected to the bottoms of the damper mounting plates 15 on two sides, and the damper mounting plates 15 have a supporting function.
Further, 1 inner chamber bottom both sides of frame body are all fixed and are equipped with second wire sheath 21, 1 inside first support 20 and the second support 22 of being equipped with respectively of frame body, first support 20 and second support 22 all pass through the bolt fastening with frame body 1, 1 inside fixed first foot sign indicating number 19 that is equipped with of frame body, first support 20 and second support 22 have the supporting role.
Furthermore, a second filter 18 and a first filter 14 are respectively fixedly arranged on one side of the first bracket 20 and one side of the second bracket 22, and the second filter 18 and the first filter 14 have a filtering function.
The using process of the invention is as follows: when the invention is used, after the water is pumped out from the constant temperature water pool by the peristaltic pump 11, the water passes through the pulse damper 16, the first filter 14 and the second filter 18 in the frame body 1, and then enters the lower blood ports of the first dialyzer 4 and the second dialyzer 33 through the pressure gauge 2, before entering the lower blood ports of the first dialyzer 4 and the second dialyzer 33, the peristaltic pump 11 measures the water volume of the pump within a set time as V0, after the water V0 with a fixed volume enters the first dialyzer 4 and the second dialyzer 33 from the lower blood ports, under the condition that the lower blood ports of the first dialyzer 4 and the second dialyzer 33 are sealed, the water flows out from one part of the first dialyzer 4 and the second dialyzer 33 across the dialysis membrane from the upper blood port, the water flow is V01, the other part does not directly flow out from the upper blood port, the water flow is V02, and flows back to the water tank through the water outlet throttle valve 6, the water sent into the first dialyzer 4 and the second dialyzer 33 by the peristaltic pump 11 is a fixed quantity V0 which is equal to the sum of the water output from the upper blood port V02 and the water output from the upper liquid port V01, namely V0 is V01+ V02, and what needs to be quantitatively controlled is the fixed quantity V0 of the peristaltic pump 11, which is used for collecting, measuring and calculating the water output from the upper liquid port V01 passing through the membrane.
The pressure gauge 2 is respectively connected with the lower blood port and the upper blood port of the first dialyzer 4 and the second dialyzer 33 and used for monitoring the pressure P1 before water enters the dialyzers after the water exits from the peristaltic pump 11 and the pressure P2 after the water enters the first dialyzer 4 and the second dialyzer 33 but does not cross the fiber membranes, the transmembrane pressure of the water crossing the fiber membranes is obtained by comparing the pressure P1 and the pressure P2 before the water enters the first dialyzer 4 and the second dialyzer 33, and the transmembrane pressure can be changed by the size of the water outlet throttle valve 6 at the backflow part, so that the water outlet quantity V1 and V2 of the fiber membranes in the first dialyzer 4 and the second dialyzer 33 under two different transmembrane pressures can be measured.
After the water outlet throttle valve 6 is opened to the maximum for a period of time, the water outlet throttle valve 6 is adjusted to enable the sum of the pressure values of an inlet and an outlet to be P0, after t1min of balance, a beaker is used for connecting the water outlet at the upper liquid port end, t2min is recorded, the volume of the received water is V1, the water outlet throttle valve 6 is adjusted again to enable the pressure of the discharged water to be the minimum reading, after t1min of balance, the beaker is used for connecting the water at the upper liquid port end again, t2min is recorded, the volume of the received water is V2, and the pressure of the inlet and the outlet is P2.
The water flux of the dialyzer is then:
)(--------------mL/m2/h/mmHg
)(--------------mL/m2/h/mmHg
)(--------------mL/m2/h/mmHg
V1and V2------------------t2Volume of water taken in ml
TMP1----P0Transmembrane pressure under the conditions expressed in Kpa
7.5-----------------1Kpa=7.5*1mmHg
S- -Membrane area of test Membrane in m2
TMP2The transmembrane pressure of the fully-opened outlet throttle valve is 1/2P2In units of Kpa
The water flux of the test membrane can be obtained by averaging the UFR calculated in the way, and the P is changed by adjusting the water outlet throttle valve 60The performance of high and low pass can be tested, the hemodialyzer of the blood and the dialyzate of a patient is introduced into the dialyzer at the same time, the hemodialyzer and the dialyzate of the patient flow in opposite directions on two sides of a dialysis membrane, the solute gradient, the osmotic gradient and the water pressure gradient on the two sides of the membrane are utilized to remove toxins and excessive water retained in the body, during measurement, a lower end liquid port is blocked by a plug, an upper end liquid port is connected into a measuring cup by a pipeline to collect and monitor the water yield, simultaneously, an injection molding support piece 5 and a support piece cushion block 7 have the functions of fixing and supporting a first dialyzer 4 and a second dialyzer 33, a foot seat 12 has the supporting function, the start-stop work of a peristaltic pump 11 is controlled by starting a switch 3, the peristaltic pump 11 is a fixed displacement pump, after the working time and the water yield of each time are set, the left and right stations of the whole machine can realize simultaneous measurement, are mutually independent and, make the polyurethane 30 of ejector pin 27 one end support first cerini dialyser cerini 4 and second cerini dialyser cerini 33 post to rotatory second knob 29 is fixed ejector pin 27, and anchor clamps fixed mode is simple, goes up unloading easy operation, and it is convenient to switch the product, can be used to the product of multiple different external diameter specifications, improves work efficiency, and the result feedback time shortens, and it is sufficient to produce the performance feedback to the required high efficiency product in production scene, and operating personnel demand is little, and convenient operation is swift, the reduce cost.
The above description is only a preferred embodiment of the present invention, and any person skilled in the art may modify the present invention or modify it into an equivalent technical solution by using the technical solution described above. Therefore, any simple modifications or equivalent substitutions made in accordance with the technical solution of the present invention are within the scope of the claims of the present invention.

Claims (7)

1. The utility model provides a measure cerini dialyser cerini hollow fiber membrane water flux tester, includes frame body (1), its characterized in that: peristaltic pumps (11) are fixedly mounted on two sides of the frame body (1), a plurality of pressure meters (2) are fixedly arranged at the top of the frame body (1) respectively, one ends of the pressure meters (2) extend into the frame body (1), pressure meter mounting seats (13) are fixedly arranged at the bottoms of the pressure meters (2), and a dialysis mechanism is arranged on the front side of the frame body (1);
the dialysis mechanism comprises a first dialyzer (4) and a second dialyzer (33), wherein the first dialyzer (4) and the second dialyzer (33) are arranged on the front side of a frame body (1), two injection molding supporting pieces (5) are respectively sleeved outside the first dialyzer (4) and the second dialyzer (33), one side of each injection molding supporting piece (5) is fixedly provided with a supporting piece cushion block (7), the supporting piece cushion block (7) is fixedly connected with the frame body (1), one side of each first dialyzer (4) and one side of each second dialyzer (33) are respectively fixedly provided with a push rod guide seat (26), the push rod guide seats (26) are fixedly connected with the frame body (1), the front sides of the push rod guide seats (26) are provided with second knobs (29), push rod guide seats (26) are internally provided with push rods (27), and the push rod guide seats (27) penetrate through the push rod guide seats (26), one end of the ejector rod (27) is fixedly connected with a polyurethane pressing block (31), the other end of the ejector rod (27) is provided with a first knob (28), and one side of the polyurethane pressing block (31) is fixedly provided with polyurethane (30).
2. The tester for measuring the water flux of the hollow fiber membrane of the dialyzer according to claim 1, wherein: the frame body (1) bottom fixedly connected with a plurality of foot seats (12), frame body (1) top is fixed to be inlayed and is equipped with two starting switch (3).
3. The tester for measuring the water flux of the hollow fiber membrane of the dialyzer according to claim 1, wherein: the frame body (1) front side is fixed respectively and is equipped with first flowmeter (9) and second flowmeter (32), first flowmeter (9) left side is located in second flowmeter (32), frame body (1) front side is fixed to be seted up first wire sheath (8), frame body (1) front side is fixed to be inlayed and is equipped with two water outlet throttle valves (6), frame body (1) rear side is equipped with backplate (23), backplate (23) one side is equipped with door handle (24).
4. The tester for measuring the water flux of the hollow fiber membrane of the dialyzer according to claim 1, wherein: peristaltic pump (11) top is fixed and is equipped with pump handle (10), peristaltic pump (11) bottom both sides all are fixed and are equipped with second foot sign indicating number (25), both sides second foot sign indicating number (25) all with frame body (1) fixed connection.
5. The tester for measuring the water flux of the hollow fiber membrane of the dialyzer according to claim 1, wherein: the frame body (1) is internally provided with a junction box (17) on the side wall, the frame body (1) is internally provided with a damper mounting plate (15) on the two side walls, and the damper mounting plate (15) is fixedly connected with a pulse damper (16) at the bottom.
6. The tester for measuring the water flux of the hollow fiber membrane of the dialyzer according to claim 1, wherein: frame body (1) inner chamber bottom both sides all are fixed and are equipped with second protecting wire cover (21), frame body (1) inside is equipped with first support (20) and second support (22) respectively, first support (20) and second support (22) all pass through the bolt fastening with frame body (1), frame body (1) inside is fixed and is equipped with first foot sign indicating number (19).
7. The tester for measuring the water flux of the hollow fiber membrane of the dialyzer according to claim 6, wherein: and a second filter (18) and a first filter (14) are respectively fixedly arranged on one side of the first bracket (20) and one side of the second bracket (22).
CN202110240869.3A 2021-03-04 2021-03-04 Measure cerini dialyser cerini hollow fiber membrane water flux tester Pending CN112945833A (en)

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Application Number Priority Date Filing Date Title
CN202110240869.3A CN112945833A (en) 2021-03-04 2021-03-04 Measure cerini dialyser cerini hollow fiber membrane water flux tester

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN202110240869.3A CN112945833A (en) 2021-03-04 2021-03-04 Measure cerini dialyser cerini hollow fiber membrane water flux tester

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Publication Number Publication Date
CN112945833A true CN112945833A (en) 2021-06-11

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Application Number Title Priority Date Filing Date
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Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104689395A (en) * 2013-12-05 2015-06-10 天津市迈克尔化工有限公司 Experimental facility for dialyzer ultrafiltration rate and clearance rate
CN109862957A (en) * 2016-10-24 2019-06-07 费森尤斯医疗护理德国有限责任公司 Method for determining the permeance property of hollow-fibre membrane

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104689395A (en) * 2013-12-05 2015-06-10 天津市迈克尔化工有限公司 Experimental facility for dialyzer ultrafiltration rate and clearance rate
CN109862957A (en) * 2016-10-24 2019-06-07 费森尤斯医疗护理德国有限责任公司 Method for determining the permeance property of hollow-fibre membrane

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