CN112891261B

CN112891261B - Composition for reducing irritation of surfactant and application of composition in soap

Info

Publication number: CN112891261B
Application number: CN202110307682.0A
Authority: CN
Inventors: 罗彪玉; 朱美金; 高宏旗; 孙成芬; 陈景晶
Original assignee: Shanghai Linqingxuan Biotechnology Co ltd
Current assignee: Shanghai Linqingxuan Biotechnology Co ltd
Priority date: 2021-03-23
Filing date: 2021-03-23
Publication date: 2023-04-07
Anticipated expiration: 2041-03-23
Also published as: CN112891261A

Abstract

The invention discloses a composition for reducing the irritation of a surfactant and application thereof in soap, wherein the composition comprises the following components in percentage by weight: sucrose: 10-50% of betaine, 10-30% of avocado oil, 5-15% of jojoba seed oil, 5-15% of macadamia nut seed oil, 5-15% of wild soybean oil and 1-5% of tocopherol. The composition is derived from natural plants, has no harm and toxic or side effect on skin, improves the fineness of foam, and can be used for preparing washing and caring products with strong dirt-removing capacity and low irritation. Can prevent the people who are sensitive to the skin of the surfactant, and has good application prospect and wide development space.

Description

Composition for reducing irritation of surfactant and application of composition in soap

Technical Field

The invention belongs to the technical field of daily washing and caring articles, and particularly relates to a composition for reducing irritation of a surfactant and application of the composition in soap.

Background

The surfactant is a substance which has an asymmetric hydrophilic-lipophilic structure and can obviously reduce the surface tension of a target solution. The surfactants respectively comprise anionic surfactants, cationic surfactants, nonionic surfactants, amphoteric surfactants and the like, and have the functions of cleaning, washing, foaming, emulsifying, solubilizing, dispersing and the like, the surfactants are more and more widely applied to a system contacting with human bodies, such as shampoo, shower gel, liquid soap, liquid detergent, facial cleanser, laundry detergent and the like which are daily personal cleaning and nursing products, and the daily products contain a large amount of surfactants, but all of the surfactants have certain irritation, and can cause irritation to fragile skin or parts when in use, so that the comfort level and the safety of the products in use are reduced.

The soap functions as a cleaning wash and is used on the skin to remove soil, skin secretions, excretions, chemicals or bacteria. The handmade soap has super cleaning power and high alkalinity, and can cause the skin to be dried and rough due to excessive fat removal after long-term use, and can damage the horny layer of the skin, and once the horny layer of the skin is damaged, the surface skin becomes more sensitive and more dry, is easy to be allergic, and can generate wrinkles prematurely to generate an aging phenomenon.

Therefore, it is highly desirable to develop a composition that reduces surfactant irritation while being applicable to soaps.

Disclosure of Invention

The invention aims to provide a composition for reducing the irritation of a surfactant and application of the composition in soap. The composition provided by the invention is derived from natural plants, has no harm or toxic and side effects on human skin, can reduce the stimulation of a surfactant and a handmade soap, has excellent cleaning, moisturizing and skin-care effects, is convenient and flexible to use, and can be added into daily washing and care products containing the surfactant and the handmade soap according to different contents.

The purpose of the invention is realized by the following technical scheme:

the invention provides a composition for reducing the irritation of a surfactant, which comprises the following components in percentage by mass:

10-50% of cane sugar;

10-30% of betaine;

5-20% of avocado oil;

5-20% of jojoba seed oil;

5-15% of macadamia nut seed oil;

5-15% of wild soybean oil;

1-5% of tocopherol.

Preferably, the composition for reducing the irritation of the surfactant comprises the following components in percentage by mass:

25-49% of sucrose;

10-30% of betaine;

5-15% of avocado oil;

5-15% of jojoba seed oil;

5-15% of macadamia nut seed oil;

5-15% of wild soybean oil;

1-5% of tocopherol.

49% of sucrose;

30% of betaine;

5% of avocado oil;

5% of jojoba seed oil;

5% of macadamia nut seed oil;

5% of wild soybean oil;

1% of tocopherol.

37% of sucrose;

20% of betaine;

10% of avocado oil;

jojoba seed oil 10%;

10% of macadamia nut seed oil;

10% of wild soybean oil;

3 percent of tocopherol.

25% of sucrose;

10% of betaine;

15% of avocado oil;

jojoba seed oil 15%;

15% of macadamia nut seed oil;

15% of wild soybean oil;

5 percent of tocopherol.

The avocado oil adopted by the invention is as follows: is derived from avocado, has high safety to skin, is rich in vitamins, sterols, lecithin and the like, can nourish the skin, enables the skin to be fine and glossy, and has good effect on dry and aged skin.

The jojoba seed oil adopted by the invention: is not easy to be oxidized, has better touch and ductility, can make the skin soft and elastic, and is easy to be absorbed by the skin.

The invention adopts the following nut shell oil: is rich in unsaturated fatty acid, and can effectively moisturize and protect skin.

The wild soybean oil adopted by the invention: the oil extracted from wild soybean can nourish skin, relieve skin dryness and roughness, make skin smooth and tender, and make skin feel soft.

The tocopherol employed in the present invention: excellent antioxidant, and can prevent or prolong the rancidity of oil. And also has effects in improving skin elasticity, moistening skin, and resisting aging.

The invention also provides the application of the composition in preparing a washing and caring product containing the surfactant.

Preferably, the weight ratio of the composition to surfactant in the laundry care product is from 0.001.

Preferably, the surfactant is selected from a combination of one or more of anionic surfactant, cationic surfactant, nonionic surfactant, amphoteric surfactant.

Preferably, the washing and care product comprises soap, shampoo, shower gel, hand sanitizer, liquid detergent, facial cleanser and laundry detergent.

The invention also provides a soap comprising the composition of any one of claims 1 to 5 and a surfactant in a weight ratio of 0.001 to 1:5.

Preferably, the soap is a handmade soap.

Compared with the prior art, the invention has the following beneficial effects:

1. the principle of the invention for reducing the surface active agent is that through a large amount of formula tests and researches, the irritation of the surface active agent to the skin depends on the structure of the surface active agent and the irritation to mucous membrane and skin is mainly caused by three factors of dissolubility, penetrability, reactivity and the like. Wherein: sucrose has excellent surface activity (lower surface tension), moisturizing ability and emulsifying ability, and is compatible with surfactants, thereby reducing the irritation index of these compounds. Betaine: is Natural Moisturizing Factor (NMF), a naturally-occurring moisturizing component in human skin, is a natural moisturizing agent, can improve the moisture content of the skin stratum corneum, keep moisture for a long time, simultaneously permeate into the skin stratum corneum to protect the balance of cells, improve the stimulation of too low pH value to the skin and reduce the occurrence of stimulation phenomenon. Various vegetable oils: the main component is triglyceride which is similar to the components of human sebum and can help repair and moisten deep skin. And (3) tocopherol: the natural components in human skin have the effects of resisting oxidation and protecting body cells from being damaged by free radicals.

Dissolution property: refers to the degree of dissolution of the surfactant into the skin's own moisturizing components (such as moisturizing factor NMF), intercellular lipids, and free amino acids and fats in the stratum corneum. Excessive dissolution of these components will destroy the skin oil and surface layers, reduce the water retention capacity of the skin, cause cell scurf to fall off, and cause skin tightness, prickling or dry sensation.

Permeability: refers to the ability of surfactants to penetrate through the skin, and this action is believed to be one of the causes of various inflammations of the skin. The penetration of the surfactant changes the original structural state of the skin and the compatibility between adjacent molecules, thereby causing contact dermatitis and dermal dermatitis, causing skin irritation and even anaphylaxis, and causing erythema and edema on the skin.

Reactivity: refers to the effect of the surfactant on the adsorption of proteins, resulting in the denaturation of proteins and the change of skin pH conditions, etc.

2. The composition is derived from natural plants, the extraction process is convenient and pollution-free, and surfactant monomers which are easy to combine with human epidermal keratin and denature the human epidermal keratin are easier to micellize by reducing the CMC (critical micelle concentration) of the surfactant and the like, so that larger or more stable micelles are formed, namely the relative concentration of the surfactant monomers is reduced, and the irritation to the skin is reduced. Furthermore, the test results show that: the added composition can also effectively care skin.

3. When the composition is used for preparing soap, the irritation of a surfactant can be reduced, the foaming power can be improved, and the hardness and the moisturizing power of the soap can be improved.

Detailed Description

The present invention will be described in detail with reference to specific examples. The following examples will assist those skilled in the art in further understanding the invention, but are not intended to limit the invention in any way. It should be noted that variations and modifications can be made by persons skilled in the art without departing from the spirit of the invention. All falling within the scope of the present invention.

Example 1

The embodiment provides a composition for reducing the irritation of a surfactant, which comprises the following components in percentage by weight:

sucrose: 49 percent;

30% of betaine;

5% of avocado oil;

5% of jojoba seed oil;

5% of macadamia nut seed oil;

5% of wild soybean oil;

1% of tocopherol.

The preparation method of the composition comprises the following steps:

A. mixing avocado oil, jojoba seed oil, macadamia nut seed oil, wild soybean oil, and tocopherol, and stirring;

B. mixing sucrose and betaine, and stirring;

C. adding B into A, mixing and stirring uniformly;

D. taking materials, detecting, and obtaining the composition after the materials are qualified.

Example 2

sucrose: 37 percent;

20% of betaine;

10% of avocado oil;

jojoba seed oil 10%;

10% of macadamia nut seed oil;

10% of wild soybean oil;

3 percent of tocopherol.

The composition was prepared in the same manner as in example 1.

Example 3

sucrose: 25 percent;

10% of betaine;

15% of avocado oil;

jojoba seed oil 15%;

15% of macadamia nut seed oil;

15% of wild soybean oil;

5 percent of tocopherol.

The composition was prepared in the same manner as in example 1.

Comparative example 1 (reduction of skin irritation)Sharp dissolution and reactive component)

The comparative example provides a composition with reduced surfactant irritancy comprising the following components in weight percent:

79% sucrose;

5% of avocado oil;

5% of jojoba seed oil;

5% of macadamia nut seed oil;

5% of wild soybean oil;

1% of tocopherol.

The composition was prepared in the same manner as in example 1.

Comparative example 2 (reduction of dissolution affecting skin irritation)

betaine: 79 percent;

5% of avocado oil;

5% of jojoba seed oil;

5% of macadamia nut seed oil;

5% of wild soybean oil;

1% of tocopherol.

The composition was prepared in the same manner as in example 1.

Comparative example 3 (reduction of penetrating ingredients affecting skin irritation)

sucrose: 50 percent;

50% of betaine.

The composition was prepared in the same manner as in example 1.

Comparative example 4

sucrose: 49 percent;

30% of betaine;

jojoba seed oil 10%;

5% of macadamia nut seed oil;

5% of wild soybean oil;

1% of tocopherol.

The composition was prepared in the same manner as in example 1.

Comparative example 5

sucrose: 49 percent;

30% of betaine;

10% of avocado oil;

5% of macadamia nut seed oil;

5% of wild soybean oil;

1% of tocopherol.

The composition was prepared in the same manner as in example 1.

Comparative example 6

sucrose: 49 percent;

30% of betaine;

5% of avocado oil;

5% of jojoba seed oil;

10% of wild soybean oil;

1% of tocopherol.

The composition was prepared in the same manner as in example 1.

Comparative example 7

sucrose: 49 percent;

30% of betaine;

5% of avocado oil;

5% of jojoba seed oil;

10% of macadamia nut seed oil;

1% of tocopherol.

The composition was prepared in the same manner as in example 1.

Comparative example 8

sucrose: 49 percent;

30% of betaine;

5% of avocado oil;

5% of jojoba seed oil;

5% of macadamia nut seed oil;

5% of camellia seed oil;

1% of tocopherol.

The composition was prepared in the same manner as in example 1.

Comparative example 9

sucrose: 49 percent;

30% of betaine;

5% of avocado oil;

5% of jojoba seed oil;

5% of safflower seed oil;

5% of wild soybean oil;

1% of tocopherol.

The composition was prepared in the same manner as in example 1.

Application example 1

The present application example provides a handmade soap comprising a soap base and the compositions prepared in the respective examples and comparative examples;

wherein the soap base is prepared from the following components in percentage by mass:

the preparation method of the soap base comprises the following steps:

A. sequentially adding stearic acid, lauric acid and palmitic acid into an emulsifying pot, heating to 80-85 ℃, and completely dissolving and transparent;

B. adding glycerin, sorbitol, propylene glycol and sodium laureth sulfate at 80-85 deg.C, and stirring;

C. mixing and dissolving water and sodium hydroxide completely in advance, slowly adding the mixture into an emulsifying pot at a temperature of between 65 and 70 ℃, heating the mixture to between 80 and 85 ℃, and stirring the mixture uniformly;

D. adding cane sugar and alcohol in turn at 80-85 ℃, and stirring for 1 hour while keeping moisture;

E. cooling to 70-75 ℃, taking materials, detecting, discharging after qualified, and cooling to obtain the handmade soap.

Effect verification 1: irritation test

The compositions prepared in all of the above examples and comparative examples were formulated with a surfactant (0.5% sls aqueous solution) in a weight ratio of 0:1, 0.05, 1, 0.2: handmade soaps (the compositions prepared in the examples and comparative examples and soap base were prepared in a weight ratio of 0:1, 0.05, 1, 0.2. The method for the skin closed patch test comprises the following steps: 30 persons of 18-60 years old are selected, qualified spot test devices with the area not more than 50mm < 2 > and the depth of about 1mm are selected, 0.020mL of the surfactant aqueous solution and the handmade soap prepared in the examples and the comparative examples are respectively put into a small chamber of the spot test device, a control hole is a blank control (no substance is put), the spot test device added with the surfactant aqueous solution and the handmade soap is pasted on the curved side of the forearm of a subject by using a hypoallergenic adhesive tape, and the hypoallergenic adhesive tape is lightly pressed by hands to be uniformly pasted on the skin for 24 hours. After the plaque removal tester was set aside for 30min at 22 + -1 deg.C and 50 + -5% humidity, the transepidermal water loss rate (TEWL) of each test well was tested, and the larger the increase in the amount of water loss of the skin, the greater the damage to the skin barrier by the sample, the greater the irritation, and the test results are shown in Table 1.

TABLE 1

As can be seen from Table 1, the compositions prepared in the examples of the present invention, when added to an epidermal active solution or a handmade soap, significantly reduced the irritation of epidermal active on skin.

Effect verification 2: moisture Capacity test-Water content of stratum corneum

The hand soap prepared in all the above examples and comparative examples was subjected to the moisture content test of the horny layer of the arm using a moisture content measuring instrument (Corneometer) for the horny layer of the skin, and the test method was: selecting 30 healthy women with age of 30 + -2 years, marking the inner side of the left and right arms with 3 × 3cm ² Testing 6 areas, firstly measuring the D0 initial value (blank value) of each testing area, respectively using an equal amount of experimental sample and a control sample in the testing area of a subject, kneading for equal circles, respectively carrying out water content testing on the three areas after the three areas are washed clean and dried by air, continuing for 4 weeks, carrying out parallel testing for 3 times, taking an average value, and recording the water content value of the horny layer.

Wherein, the change rate is relative to the change rate before use, and the calculation formula is as follows:

delta (difference) = T4-T0 after four weeks

Wherein T0 is the stratum corneum moisture content value prior to application of the cosmetic to the test area.

T4-stratum corneum moisture content value after four weeks of cosmetic application in the test area.

N-number of subjects.

The test results are shown in table 2, the higher the skin moisture content, the better the skin moisturizing performance and the better the skin barrier function. The comparative example is obviously different from the examples, and the composition of the invention has better moisture retention effect when being applied to handmade soap.

TABLE 2

As can be seen from Table 2, the long-term use of the handmade soap accelerates the water loss on the skin surface, resulting in dry skin, but the composition of the present invention can reduce the water loss and has a certain moisturizing effect when applied to the handmade soap.

Effect verification 3: foaming force test

The foam height at 0min is used as the foaming force detection index of the sample to be tested, and the foam height after 5min is used as the foam stability test index of the sample to be tested (the foam height at 0min and 5min is respectively tested by adopting a Roche foam tester for detection, wherein the soap solution concentration is 2.5wt percent).

TABLE 3

As can be seen from Table 3, the composition of the present invention has a strong foaming power and a more stable foam when applied to a handmade soap.

Effect verification 4: handmade soap hardness test

The invention utilizes a texture analyzer to test the hardness of the soap, adopts a P/2 probe to carry out a puncture experiment, and tests the parameters as follows: the speed before measurement is 2mm/s, the penetration speed is 1mm/s, and the speed after measurement is as follows: 10mm/s, the minimum perception force is 5g, the puncture depth is not less than 10mm, and the induction force threshold is 2g; hardness evaluation criteria: the force value (g) corresponding to the maximum peak point.

TABLE 4

	Hardness per gram
		Example 1 (composition: handmade soap = 0:1)	3107±0.03
Example 1 (composition: handmade soap =0.05	3221±0.02
		Example 1 (composition: handmade soap =0.2	3343±0.03
Example 2 (composition: handmade soap =0.05	3196±0.01
		Example 2 (composition: handmade soap =0.2	3307±0.02
Example 3 (composition: handmade soap =0.05	3168±0.01
		Example 3 (composition: handmade soap =0.2	3264±0.04
Comparative example 1 (composition: handmade soap =0.05	3132±0.03
		Comparative example 2 (composition: handmade soap =0.05	3135±0.02
Comparative example3 (composition: handmade soap =0.05	3123±0.02
		Comparative example 4 (composition: handmade soap =0.05	3127±0.04
Comparative example 5 (composition: handmade soap =0.05	3141±0.02
		Comparative example 6 (composition: handmade soap =0.05	3138±0.01
Comparative example 7 (composition: handmade soap =0.05	3140±0.02
		Comparative example 8 (composition: handmade soap =0.05	3151±0.01
Comparative example 9 (composition: handmade soap =0.05	3160±0.04

As can be seen from Table 4, the use of the composition of the present invention in handmade soaps can increase the hardness of the handmade soaps.

In conclusion, the composition can obviously reduce the irritation of the surfactant, and when the composition is applied to the handmade soap, the irritation of the handmade soap can be obviously reduced, and meanwhile, the foaming power of the foam of the handmade soap is improved, the hardness of the handmade soap is improved, and the moisture retention of the handmade soap is improved.

The invention has many applications, and the above description is only a preferred embodiment of the invention. It should be noted that the above examples are only for illustrating the present invention, and are not intended to limit the scope of the present invention. It will be apparent to those skilled in the art that various modifications can be made without departing from the principles of the invention and these modifications are to be considered within the scope of the invention.

Claims

1. The application of a composition for reducing the irritation of a surfactant in preparing a washing and caring product containing the surfactant is characterized in that the composition comprises the following components in percentage by mass:

10-50% of cane sugar;

10-30% of betaine;

5-20% of avocado oil;

5-20% of jojoba seed oil;

5-15% of macadamia nut seed oil;

5-15% of wild soybean oil;

1-5% of tocopherol;

the surfactant is sodium laureth sulfate;

the weight ratio of the composition to surfactant in the laundry care product is from 0.05.

2. The use according to claim 1, wherein the composition comprises the following components in percentage by mass:

25-49% of sucrose;

10-30% of betaine;

5-15% of avocado oil;

5-15% of jojoba seed oil;

5-15% of macadamia nut seed oil;

5-15% of wild soybean oil;

1-5% of tocopherol.

3. The use according to claim 1, wherein the composition comprises the following components in percentage by mass:

49% of sucrose;

30% of betaine;

5% of avocado oil;

5% of jojoba seed oil;

5% of macadamia nut seed oil;

5% of wild soybean oil;

1% of tocopherol.

4. The use according to claim 1, wherein the composition comprises the following components in percentage by mass:

37% of sucrose;

20% of betaine;

10% of avocado oil;

jojoba seed oil 10%;

10% of macadamia nut seed oil;

10% of wild soybean oil;

3 percent of tocopherol.

5. The use according to claim 1, wherein the composition comprises the following components in percentage by mass:

25% of sucrose;

10% of betaine;

15% of avocado oil;

jojoba seed oil 15%;

15% of macadamia nut seed oil;

15% of wild soybean oil;

5 percent of tocopherol.

6. The use according to claim 1, wherein the cleaning products comprise soaps, shampoos, body washes, hand cleansers, facial washes, and laundry detergents.

7. A soap comprising the composition of any of claims 1-5 and a surfactant in a weight ratio of 0.05 to 1:5.