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CN112807254A - Skin repair composition and application thereof in cosmetics - Google Patents

Skin repair composition and application thereof in cosmetics Download PDF

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Publication number
CN112807254A
CN112807254A CN202010207267.3A CN202010207267A CN112807254A CN 112807254 A CN112807254 A CN 112807254A CN 202010207267 A CN202010207267 A CN 202010207267A CN 112807254 A CN112807254 A CN 112807254A
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Prior art keywords
parts
skin
tripeptide
copper
extract
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Inventor
梁锋
熊中立
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Shanghai Zhengxin Biotechnology Co ltd
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Shanghai Zhengxin Biotechnology Co ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9789—Magnoliopsida [dicotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/59—Mixtures
    • A61K2800/592—Mixtures of compounds complementing their respective functions

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
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  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Chemical & Material Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • Cosmetics (AREA)

Abstract

The invention relates to a skin repair composition and application thereof in cosmetics, wherein the skin repair composition consists of a peony root extract and tripeptide-1 copper. The radix Paeoniae extract can significantly improve synthesis of triglyceride in keratinocyte, and tripeptide-1 copper can effectively promote production of Collagen (Collagen) and elastic (Elastin) protein, increase blood vessel growth and antioxidant capacity, stimulate production of glucose polyamine (GAGs), and help skin recover natural ability of self-repairing. The radix paeoniae extract and tripeptide-1 copper are combined for use, so that a synergistic effect can be achieved, and an effect that 1+1 is larger than 2 is achieved, so that the barrier function of skin is effectively repaired, and the skin is enabled to be in a healthy and active state.

Description

Skin repair composition and application thereof in cosmetics
Technical Field
The invention relates to the field of cosmetics, in particular to a skin repair composition and application thereof in cosmetics.
Background
With the existing work pressure, external factors such as environmental pollution, food hormones, external light radiation and the like, and night-out, computer radiation and the like, the factors bring a series of skin problems such as dryness, sensitivity, redness, desquamation, roughness, acne and the like. The root cause of these problems is actually the damage of the skin barrier, and when these problems occur, the skin barrier repair is carried out in time. The concept of skin barrier, which is composed of sebum membrane, horny layer, lipid, etc., is gradually concentrated into human mind in recent years, and can prevent external harmful substances, irritants, sunlight, etc. from entering the skin, and has moisture-retaining effect.
The skin is divided into several layers: epidermis layer, dermis layer, subcutaneous tissue. These three large layers are subdivided into several finer layers, such as the epidermis: stratum corneum, stratum lucidum, stratum granulosum, stratum spinosum, stratum basale. Different layers of the skin have different functions, and different skin problems can occur when different layers are damaged. Therefore, the essence of the skin barrier damage is that the function of a certain layer of the skin is damaged, and the treatment method also aims at the damaged layer to repair the damaged layer so as to achieve the effect of drawing salary at the bottom of the kettle.
Triglyceride (TG) is an important component of sebaceous gland lipid, and the increase of TG is more beneficial to the recovery of skin barrier function for sensitive muscles and inflammatory muscles, and stores and provides energy, and the peony root extract can obviously improve the synthesis of triglyceride in keratinocytes.
Disclosure of Invention
Based on this, there is a need for a skin repair composition containing an extract of paeonia lactiflora pall, which can perform a skin repair function.
In addition, the skin repair composition has a need of providing an application in cosmetics.
A skin repair composition consisting of an extract of Paeonia lactiflora pall and tripeptide-1 copper.
The use of a skin repair composition as described above in cosmetics.
A skin repairing cosmetic comprises radix Paeoniae extract, tripeptide-1 copper, additive and water.
The radix Paeoniae extract can significantly improve synthesis of triglyceride in keratinocyte, and tripeptide-1 copper can effectively promote production of Collagen (Collagen) and elastic (Elastin) protein, increase blood vessel growth and antioxidant capacity, stimulate production of glucose polyamine (GAGs), and help skin recover natural ability of self-repairing. The radix paeoniae extract and tripeptide-1 copper are combined for use, so that a synergistic effect can be achieved, and an effect that 1+1 is larger than 2 is achieved, so that the barrier function of skin is effectively repaired, and the skin is enabled to be in a healthy and active state.
Detailed Description
In order that the invention may be more fully understood, reference will now be made to the following description taken in conjunction with the accompanying drawings. Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. The terminology used in the description of the invention herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention.
The application discloses a skin repair composition, which consists of a peony root extract and tripeptide-1 copper.
The radix Paeoniae extract can significantly improve synthesis of triglyceride in keratinocyte, and tripeptide-1 copper can effectively promote production of Collagen (Collagen) and elastic (Elastin) protein, increase blood vessel growth and antioxidant capacity, stimulate production of glucose polyamine (GAGs), and help skin recover natural ability of self-repairing. The radix paeoniae extract and tripeptide-1 copper are combined for use, so that a synergistic effect can be achieved, and an effect that 1+1 is larger than 2 is achieved, so that the barrier function of skin is effectively repaired, and the skin is enabled to be in a healthy and active state.
Specifically, the skin repair composition comprises the following components in parts by mass: 0.2 to 2 parts of peony root extract and 2 to 10 parts of tripeptide-1 copper.
In a specific example, the skin repair composition includes 0.4 parts, 0.6 parts, 0.8 parts, 1 part, 1.2 parts, 1.4 parts, 1.6 parts or 1.8 parts of the paeonia lactiflora root extract, and 2 parts, 3 parts, 4 parts, 5 parts, 6 parts, 7 parts, 8 parts or 9 parts of the tripeptide-1 copper.
Preferably, when the skin repair composition is used, the mass percentage concentration of the peony root extract is 0.2-2%, and the mass percentage concentration of tripeptide-1 copper is 2-10%.
Such a skin repair composition can be applied in various fields, and in particular, it can be applied in cosmetics.
According to the regulations of the regulations on the supervision and control of cosmetics and hygiene, cosmetics refer to "daily chemical industry products for cleaning, removing bad smell, caring skin, beautifying and decorating by spreading any part (skin, hair, nails, lips, etc.) on the surface of human body by smearing, spraying or other similar methods".
Therefore, skin care products also belong to cosmetics.
Specifically, the cosmetic may be a facial mask liquid, skin lotion, essence, lotion, cream or makeup.
The application also discloses a skin repair cosmetic, which consists of the peony root extract, tripeptide-1 copper, an additive and water.
The radix Paeoniae extract can significantly improve synthesis of triglyceride in keratinocyte, and tripeptide-1 copper can effectively promote production of Collagen (Collagen) and elastic (Elastin) protein, increase blood vessel growth and antioxidant capacity, stimulate production of glucose polyamine (GAGs), and help skin recover natural ability of self-repairing. The radix paeoniae extract and tripeptide-1 copper are combined for use, so that a synergistic effect can be achieved, and an effect that 1+1 is larger than 2 is achieved, so that the barrier function of skin is effectively repaired, and the skin is enabled to be in a healthy and active state.
Every one hundred parts of skin repair cosmetics comprise the following components in parts by mass: 0.2 to 2 parts of peony root extract, 2 to 10 parts of tripeptide-1 copper, additive and the balance of water.
In a specific example, the part by mass of the paeonia lactiflora root extract in the skin repair cosmetic is 0.4 part, 0.6 part, 0.8 part, 1 part, 1.2 parts, 1.4 parts, 1.6 parts or 1.8 parts, and the part by mass of the tripeptide-1 copper is 2 parts, 3 parts, 4 parts, 5 parts, 6 parts, 7 parts, 8 parts or 9 parts.
The peony root extract is usually an alcohol extraction product.
In this embodiment, the paeonia radix extract is a paeonia radix extract. In other embodiments, other peony root extracts may be selected, for example, white peony root extract.
The additives are generally selected according to the actual product and determined in parts by mass.
The additive is a plurality of raw materials required by the production of cosmetics. Specifically, the additive may be at least one selected from the group consisting of a moisturizer, an oil, an antioxidant, a preservative, a sunscreen, a pigment, an adhesive and a perfume.
Taking the skin repairing cosmetic as cream (face cream) as an example, the mass part of the additive can be 29.5 parts. At this time, 29.5 parts of the additive may be 0.2 parts of carbomer, 5 parts of butanediol, 5 parts of methylpropanediol, 1.5 parts of betaine, 0.5 parts of urea, 0.2 parts of allantoin, 1.4 parts of steareth-21, 1.2 parts of steareth-2, 2.6 parts of cetostearyl alcohol, 1 part of polydimethylsiloxane, 5 parts of squalane, 1.5 parts of shea butter, 0.3 parts of tocopheryl acetate, 0.1 parts of phytosterol oleate, 2 parts of caprylic/capric triglyceride, 1 part of isononyl isononanoate, 1.8 parts of G57, 0.1 parts of preservative, and 0.1 parts of essence.
When the skin-repairing cosmetic is a cream (face cream), the preparation method thereof may be:
weighing various raw materials according to the mass parts, adding carbomer into butanediol and methyl propylene glycol, stirring and dispersing, adding water, betaine, urea and allantoin, heating to 75-80 ℃, keeping the temperature and stirring until the materials are dissolved uniformly to obtain a first mixed solution;
mixing steareth-21, steareth-2, cetostearyl alcohol, polydimethylsiloxane, squalane, shea butter, tocopheryl acetate, phytosterol oleate, caprylic/capric triglyceride and isononyl isononanoate, heating to 75-80 ℃, preserving heat and stirring until the mixture is dissolved uniformly to obtain a second mixed solution;
mixing the first mixed solution and the second mixed solution (preferably adding the second mixed solution into the first mixed solution) under stirring to obtain a third mixed solution;
homogenizing the third mixed solution for 5-8 min, then adding G57 and continuing homogenizing for 5-8 min to obtain a fourth mixed solution; and
cooling the fourth mixture to about 45 deg.C, sequentially adding tripeptide-1 copper, radix Paeoniae extract, antiseptic and essence, stirring, and cooling to room temperature to obtain cream.
DETAILED DESCRIPTION OF EMBODIMENT (S) OF INVENTION
Example 1: preparation of repair face cream
According to the total weight part of 100 parts, the part of the radix paeoniae rubra extract is 0.5 part, the part of tripeptide-1 copper is 1 part, and the additive comprises 0.2 part of carbomer, 5 parts of butanediol, 5 parts of methyl propylene glycol, 1.5 parts of betaine, 0.5 part of urea, 0.2 part of allantoin, 1.4 parts of steareth-21, 1.2 parts of steareth-2, 2.6 parts of cetostearyl alcohol, 1 part of polydimethylsiloxane, 5 parts of squalane, 1.5 parts of shea butter, 0.3 part of tocopheryl acetate, 0.1 part of phytosterol oleate, 2 parts of caprylic/capric triglyceride, 1 part of isononyl isononanoate, 1.8 parts of G57, 0.1 part of preservative, 0.1 part of essence and the balance of water.
Weighing various raw materials according to the mass parts, adding carbomer into butanediol and methyl propylene glycol, stirring and dispersing, adding water, betaine, urea and allantoin, heating to 75-80 ℃, keeping the temperature and stirring until the materials are dissolved uniformly to obtain a first mixed solution;
mixing steareth-21, steareth-2, cetostearyl alcohol, polydimethylsiloxane, squalane, shea butter, tocopheryl acetate, phytosterol oleate, caprylic/capric triglyceride and isononyl isononanoate, heating to 75-80 ℃, preserving heat and stirring until the mixture is dissolved uniformly to obtain a second mixed solution;
mixing the first mixed solution and the second mixed solution (preferably adding the second mixed solution into the first mixed solution) under stirring to obtain a third mixed solution;
homogenizing the third mixed solution for 5-8 min, then adding G57 and continuing homogenizing for 5-8 min to obtain a fourth mixed solution; and
cooling the fourth mixed solution to about 45 ℃, sequentially adding tripeptide-1 copper, the peony root extract, the preservative and the essence, uniformly stirring, and cooling to room temperature to obtain the skin repairing cream.
Example 2: preparation of repair face cream
Example 2 is different from example 1 only in that the red peony extract is 1.2 parts, the tripeptide-1 copper is 4 parts, and the others are not different.
Skin repair cream was prepared in the same manner as in example 1.
Example 3: preparation of skin repairing cream
Example 3 is different from example 1 only in that the part of the extract of red peony is 2 parts, the part of tripeptide-1 copper is 10 parts, and the others are not different.
Skin repair cream was prepared in the same manner as in example 1.
Example 4: skin repair efficacy test based on human keratinocytes (triglyceride based)
Raw materials and drugs
Human keratinocytes (obtained from a 54-year-old donor), DPBS (bosch de), DMSO (Sigma), trypsin (Sigma), 70% alcohol, NaOH, radix Paeoniae Rubra extract (liquid, Shanghai nux xi Zi Co., Ltd.), tripeptide-1-copper (Yun xi chemical).
Device
CO2Incubator (Thermo), clean bench (Sujing Antai), inverted microscope (Olympus), micro-oscillator (its Linbel), Triglyceride detection Kit (triglycerid Quantification Colorimetric/Fluorometric Kit, Ref No.: K622-100, Manufacturer: Biovision), incubator (Tester).
1) Preparation of a test sample: based on the cytotoxicity assay, efficacy assay concentrations were determined and corresponding samples were prepared according to table 1 below, using DMEM medium as the solvent.
Table 1: design of sample experiment
Figure BDA0002421557830000061
Figure BDA0002421557830000071
CaCl2Is alreadySubstances known to increase triglyceride expression may be used for the positive control.
2) Cell culture: human keratinocytes were obtained from a 54 year old donor, and for the experiments, keratinocytes had been cultured in monolayers until 100% confluence was reached. After digesting human keratinocytes, the cells were dispersed in DMEM medium, counted in a Hemacytometer, and then diluted with DMEM to a concentration of 5X 104cells/mL. The diluted cell solutions were inoculated into 6-well plates, each containing 2mL of 1X 105cells/well. At 37 ℃ 5% CO2Was cultured in an incubator for 24 hours. After 24 hours of cell culture, the cells were observed for complete adherent growth, and if the cells were completely adherent, the original medium was removed and washed with DPBS.
3) Sample addition: after DPBS was removed, the samples prepared above were added separately, and after sample addition, the mixture was placed at 37 ℃ in 5% CO2Was cultured in an incubator for 48 hours.
4) Collecting and detecting supernatant: collecting the culture medium, centrifuging at 13500rpm for 10min, collecting the precipitate to obtain cells, crushing the cells, centrifuging at 13500rpm for 10min, collecting the supernatant, and measuring by using a specific triglyceride detection kit to obtain the triglyceride content in the culture medium corresponding to different samples, which is shown in Table 2 below.
Table 2: triglyceride content in the culture medium corresponding to different samples
Figure BDA0002421557830000072
*: compared with the control group 3, the difference has statistical significance (p is less than 0.05);
**: compared with the control group 3, the difference has statistical significance (p is less than 0.01);
***: the difference was statistically significant (p < 0.001) compared to control 3.
As can be seen from Table 2, the control groups 1 to 3 and the sample groups 1 to 3 can both play a role in improving the expression of triglyceride, and the sample groups 1 to 3 obviously enhance the expression of triglyceride more than the control groups 1 to 3. It can be seen that by combining the use of the peony root extract with the tripeptide-1 copper, the synergistic effect of the two increases the synthesis of triglycerides, resulting in an effect of 1+1 > 2.
In addition, sample group 2 has the strongest capacity of improving the expression of triglyceride in sample groups 1 to 3.
The above-mentioned embodiments only express several embodiments of the present invention, and the description thereof is more specific and detailed, but not construed as limiting the claims. It should be noted that, for a person skilled in the art, several variations and modifications can be made without departing from the inventive concept, which falls within the scope of the present invention. Therefore, the protection scope of the present patent shall be subject to the appended claims.

Claims (10)

1. A skin rejuvenation composition which comprises an extract of paeonia lactiflora pall and tripeptide-1 copper.
2. The skin rejuvenation composition as claimed in claim 1 wherein said skin rejuvenation composition consists of, in parts by mass: 0.2 to 2 parts of peony root extract and 2 to 10 parts of tripeptide-1 copper.
3. The skin rejuvenation composition as defined in claim 2 wherein said paeonia lactiflora root extract is present in an amount of 0.4, 0.6, 0.8, 1, 1.2, 1.4, 1.6 or 1.8 parts by weight;
the tripeptide-1 copper is prepared from 2 parts, 3 parts, 4 parts, 5 parts, 6 parts, 7 parts, 8 parts or 9 parts by mass.
4. The skin rejuvenation composition as claimed in any one of claims 1 to 3 wherein, in use, the concentration of said paeonia lactiflora extract is 0.2-2% by weight and the concentration of said tripeptide-1 copper is 2-10% by weight.
5. Use of a skin rejuvenation composition according to any one of claims 1 to 4 in cosmetics.
6. The use according to claim 5, wherein the cosmetic product is a facial mask solution, a skin lotion, a serum, an emulsion, a cream or a make-up.
7. A skin-repairing cosmetic is characterized by comprising radix Paeoniae extract, tripeptide-1 copper, additive and water.
8. The skin repair cosmetic according to claim 7, wherein the skin repair cosmetic consists of, in parts by mass, per one hundred parts of the following components: 0.2 to 2 parts of peony root extract, 2 to 10 parts of tripeptide-1 copper, additive and the balance of water.
9. The skin repair cosmetic according to claim 8, wherein the part by mass of the peony root extract is 0.4 part, 0.6 part, 0.8 part, 1 part, 1.2 parts, 1.4 parts, 1.6 parts, or 1.8 parts;
the tripeptide-1 copper is prepared from 2 parts, 3 parts, 4 parts, 5 parts, 6 parts, 7 parts, 8 parts or 9 parts by mass.
10. The skin repair cosmetic according to claim 8, wherein the additive is at least one selected from the group consisting of moisturizers, oils, antioxidants, preservatives, sunscreens, pigments, adhesives and fragrances.
CN202010207267.3A 2020-03-23 2020-03-23 Skin repair composition and application thereof in cosmetics Pending CN112807254A (en)

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