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CN112730277A - Automatic analyzer and reagent library thereof - Google Patents

Automatic analyzer and reagent library thereof Download PDF

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Publication number
CN112730277A
CN112730277A CN202010833986.6A CN202010833986A CN112730277A CN 112730277 A CN112730277 A CN 112730277A CN 202010833986 A CN202010833986 A CN 202010833986A CN 112730277 A CN112730277 A CN 112730277A
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CN
China
Prior art keywords
reagent
conduit
reagent storage
reservoir tank
layers
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202010833986.6A
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Chinese (zh)
Inventor
崔尧
侯玉翠
新野俊之
王新珉
朱胜男
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Canon Medical Systems Corp
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Canon Medical Systems Corp
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Publication date
Application filed by Canon Medical Systems Corp filed Critical Canon Medical Systems Corp
Priority to JP2020180771A priority Critical patent/JP2021067694A/en
Publication of CN112730277A publication Critical patent/CN112730277A/en
Pending legal-status Critical Current

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    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/31Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01Arrangements or apparatus for facilitating the optical investigation
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N2035/00346Heating or cooling arrangements
    • G01N2035/00435Refrigerated reagent storage

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  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)

Abstract

An automatic analysis device according to an embodiment of the present invention includes: a sample dispensing arm, a reagent dispensing arm, a photometric unit, and a reagent storage. The sample dispensing arm dispenses a test sample from a sample container containing the test sample into a reaction container. The reagent dispensing arm dispenses a reagent from a reagent container containing the reagent into a reaction container. The photometric unit performs photometry on the mixed liquid in the reaction container. The reagent library has: a reagent storage tank for storing reagent containers; a reagent reservoir cover covering the reagent reservoir groove; a conduit pipe disposed along a wall surface of the reagent reservoir tank; a cooling portion for cooling the refrigerant; and a flow pump connected to the starting end and the terminating end of the conduit to flow the refrigerant in the conduit. According to the present embodiment, the conduit is disposed along the wall surface of the reagent storage tank, and the refrigerant is made to flow through the conduit, whereby the inside of the reagent storage tank can be uniformly and effectively cooled.

Description

Automatic analyzer and reagent library thereof
Technical Field
The present invention relates to an automatic analyzer and a reagent kit for analyzing components of a test sample extracted from a subject, and more particularly, to an automatic analyzer and a reagent kit for analyzing components contained in a body fluid such as human blood or urine, which can be cooled.
Background
The automatic analyzer measures changes in color tone and the like caused by a reaction between a test sample dispensed into a reaction vessel and a mixed solution of reagents suitable for each item, for biochemical test items, immunological test items and the like, to determine the concentrations of various components in the test sample and the activity of enzymes. In this automatic analyzer, measurement of an item selected in accordance with an examination is performed from among a large number of items that can be measured by setting analysis conditions for each test sample. Then, a reagent suitable for the test sample and the selected item is dispensed into the reaction container by the sample and reagent dispensing probe, and the dispensed mixture of the test sample and the reagent is stirred by the stirrer and measured by the photometry section.
Incidentally, reagent containers containing reagents of which the number of items can be measured are stored in a reagent reservoir composed of a reagent reservoir well and a reagent reservoir lid, and the stored reagent containers are kept cold to prevent deterioration of analysis data due to denaturation of the reagents. As a method of cooling the reagent container, a cooling method is known in which a coolant is fed into the reagent chamber by using a fan to cool the periphery of the reagent container.
However, in the method of feeding the refrigerant into the reagent storage, when a large number of reagent containers are stored, it is difficult to apply cold air between the reagent containers and to uniformly keep the reagent containers cold. In addition, in an automatic analysis device that handles a large number of inspection items, there is a problem in that: since it is necessary to arrange a plurality of reagents, it takes time to cool the inside of such a large reagent storage to a predetermined temperature by using a large reagent storage such as a double reagent storage in which reagent containers can be arranged in a double concentric circle.
Disclosure of Invention
The invention aims to provide an automatic analyzer and a reagent storage thereof, which can uniformly and effectively keep the interior of the reagent storage cold.
In order to achieve the above object, an automatic analyzer according to an embodiment of the present invention includes: a sample dispensing arm, a reagent dispensing arm, a photometric unit, and a reagent storage. The sample dispensing arm dispenses a test sample from a sample container containing the test sample into a reaction container. The reagent dispensing arm dispenses a reagent from a reagent container containing the reagent into the reaction container. And the photometric unit performs photometry on the mixed liquid in the reaction container. The reagent library has: a reagent storage tank for storing the reagent container; a reagent reservoir cover covering the reagent reservoir groove; a conduit disposed along a wall surface of the reagent reservoir tank; a cooling section for cooling the refrigerant; and a flow pump connected to a start end and a finish end of the conduit to flow the refrigerant in the conduit.
Further, a reagent library of an automatic analyzer according to an embodiment of the present invention includes: reagent storehouse groove, reagent storehouse lid, pipe, cooling part and flow pump. The reagent storage tank stores a reagent container that contains a reagent used for analysis in the automatic analyzer.
A reagent reservoir cover covers the reagent reservoir trough. The conduit is disposed along a wall surface of the reagent reservoir tank. The cooling unit cools the refrigerant. A flow pump flows the refrigerant in the conduit.
According to the present embodiment, the conduit is disposed along the wall surface of the reagent storage tank, and the refrigerant is made to flow through the conduit, whereby the inside of the reagent storage tank can be uniformly and effectively cooled.
Drawings
Fig. 1 is a diagram showing a configuration of an automatic analyzer according to an embodiment of the present invention;
FIG. 2 is a view showing the direction A-A of the first reagent library of FIG. 1 according to the first embodiment of the present invention;
FIG. 3 is a view showing the direction A-A of the first reagent library of FIG. 1 according to the second embodiment of the present invention;
FIG. 4 is a view showing the direction A-A of the first reagent library of FIG. 1 according to the third embodiment of the present invention;
FIG. 5 is a schematic view of the bottom of the first reagent magazine of FIG. 1 according to the ninth embodiment of the present invention;
FIG. 6 is a view showing the direction A-A in the first reagent storage of FIG. 1 according to the fourth embodiment of the present invention;
FIG. 7 is an A-A view of the first reagent library of FIG. 1 according to a fifth embodiment of the present invention;
FIG. 8 is a view showing the direction A-A of the first reagent library of FIG. 1 according to the sixth embodiment of the present invention;
FIG. 9 is a view showing the direction A-A of the first reagent library of FIG. 1 according to the seventh embodiment of the present invention;
FIG. 10 is a view showing the direction A-A of the first reagent library of FIG. 1 according to the eighth embodiment of the present invention;
FIG. 11 is a view showing the direction A-A in the first reagent storage of FIG. 1 according to the eleventh embodiment of the present invention;
fig. 12 is a control flowchart of the refrigerant flow path according to the eighth embodiment of the present invention;
fig. 13 is a schematic view showing the arrangement of a catheter on a reagent cartridge cover according to a tenth embodiment of the present invention.
Detailed Description
An embodiment of an automatic analyzer according to the present invention will be described below with reference to fig. 1 to 13.
Fig. 1 is a diagram showing a configuration of an automatic analyzer according to an embodiment of the present invention. The automatic analyzer 100 includes: an analysis unit 1 having an analysis means for measuring a standard sample and a test sample for each item; an analysis control unit 2 that controls the measurement operation of each analysis cell in the analysis unit 1; and a data processing unit 3 for generating a calibration curve and analysis data by performing measurement processing on the standard sample and the test sample and outputting the standard sample data and the test sample data from the analysis unit 1.
The analysis unit 1 includes: a sample container 4 for storing samples such as a standard sample and a test sample; a disk sampler 5 that rotatably holds the sample container 4; a reagent container 6 that contains a first reagent for analyzing a component of each item contained in a sample; and a first reagent storage 7 having a holding portion for rotatably holding the reagent container 6 and a reagent storage groove for storing the holding portion.
In addition, the method comprises the following steps: a reader 8 for reading information of the barcode label attached to the reagent container 6; a reagent container 9 that accommodates a second reagent that mates with the first reagent; a second reagent storage 10 having a holding portion for rotatably holding the reagent container 9 and a reagent storage groove for accommodating the holding portion; and a reader 11 for reading information of the barcode label attached to the reagent container 9.
Further, the device is provided with: a sample dispensing arm 13 that holds a sample dispensing probe that performs dispensing by sucking a sample out of the sample container 4 and discharging the sample into the reaction container 12, so as to be rotatable and liftable; a first reagent dispensing arm 14 that holds a first reagent dispensing probe for performing dispensing by sucking a first reagent from the reagent container 6 in the first reagent storage 7 and discharging the first reagent into the reaction container 12, so as to be rotatable and movable up and down; and a second reagent dispensing arm 15 that holds a second reagent dispensing probe for performing dispensing by sucking a second reagent from the second reagent storage 10 and discharging the second reagent into the reaction vessel 12 so as to be rotatable and movable up and down.
Further, the device is provided with: a reaction disk 16 that holds a plurality of reaction containers 12 that are arranged on the circumference of the circle so as to be rotatable and movable and that accommodate the sample, the first reagent, and the second reagent discharged from each dispensing probe; a stirring unit 17 that stirs a mixture of the sample and the first reagent dispensed into the reaction container 12 and a mixture of the sample, the first reagent, and the second reagent; a photometric unit 18 that measures the reaction container 12 in which each of the mixed solutions is stored (that is, the photometric unit 18 measures the light of the mixed solution in the reaction container 12); and a cleaning unit 19 for holding a cleaning nozzle for cleaning the inside of the reaction vessel 12 while sucking out each mixed liquid in the measured inside of the reaction vessel 12 and a drying nozzle for drying the inside of the reaction vessel 12 so as to be movable up and down.
The photometric unit 18 irradiates the rotating reaction vessel 12 with light, converts the light transmitted through the mixture solution containing the standard sample into absorbance, generates standard sample data, and outputs the standard sample data to the data processing unit 3. The light transmitted through the liquid mixture containing the test sample is converted into absorbance to generate test sample data, and then the test sample data is output to the data processing unit 3. Further, each analysis cell such as the reaction vessel 12, the sample dispensing probe of the sample dispensing arm 13, the first reagent dispensing probe of the first reagent dispensing arm 14, the second reagent dispensing probe of the second reagent dispensing arm 15, and the stirring unit 19 after the measurement is cleaned is used again for the measurement.
The analysis control unit 2 includes: a mechanism section 20 including a mechanism that drives each analysis unit of the analysis section 1; and a control section 21 that controls each of the mechanisms of the mechanism section 20. The mechanism unit 20 includes: a mechanism for rotating the holding portion of the first reagent storage 7, the holding portion of the second reagent storage 10, and the disk sampler 5; a mechanism for rotating the reaction disk 16; a mechanism for rotating and moving up and down the sample dispensing arm 13, the first reagent dispensing arm 14, the second reagent dispensing arm 15, and the stirring unit 17; and a mechanism for moving the cleaning unit 19 up and down.
Further, the apparatus comprises: a mechanism for driving a sample dispensing pump that sucks and discharges a sample from a sample dispensing probe of the sample dispensing arm 13; a mechanism for driving a first reagent pump that aspirates and discharges a first reagent from a first reagent dispensing probe of the first reagent dispensing arm 14; a mechanism for driving a second reagent pump that aspirates and discharges a second reagent from a second reagent dispensing probe of the second reagent dispensing arm 15; a mechanism for stirring the stirring members of the driving stirring unit 17; a mechanism for driving a cleaning pump that sucks the mixed liquid from the cleaning nozzle of the cleaning unit 19 and discharges and sucks the cleaning liquid; and a mechanism for driving a drying pump that sucks out from the drying nozzle of the cleaning unit 19. Next, the configuration of the first reagent storage 7 and the second reagent storage 10 in the analyzer 1 will be described in detail with reference to fig. 2. Here, the first reagent storage 7 as a double reagent storage will be described as an example.
In fig. 2, the first reagent reservoir 7 includes: a reagent storage tank 200 for storing the reagent container 6; a detachable reagent storage cover 202 for covering the reagent storage well 200; a first holding portion 203 and a second holding portion 204 (the first holding portion 203 and the second holding portion 204 are concentric table-shaped) which rotatably hold the reagent vessel 6 stored in the reagent well 200; a first motor (drive mechanism) 205 that rotates the first holding portion 203; a second motor (drive mechanism) 206 that rotates the second holding portion 204; a conduit 207 disposed along the wall surface of the reagent reservoir tank 200; a cooling unit 208 for cooling the refrigerant; and a flow pump 209 connected to the beginning and end of the conduit 207 to flow the refrigerant in the conduit 207. The first reagent storage 7 includes a heat insulating portion 201 that insulates the reagent storage groove 200 outside the reagent storage groove 200.
Referring to fig. 5, a drain opening 502 is formed in a bottom 500 of the reagent reservoir tank 200 of the first reagent reservoir 7, and the drain opening 502 is used to drain dew condensation water generated by cooling the inside of the first reagent reservoir 7 to the outside of the first reagent reservoir 7.
Further, in order to rotate the first holding portion 203 and the second holding portion 204 that hold the reagent vessel 6 stored in the reagent storage well 200, a transmission portion 503 is formed at the bottom of the reagent storage well 200, and the transmission portion 503 is used to transmit the power of the first motor 205 and the second motor 206 provided outside the reagent storage well 200 to the first holding portion 203 and the second holding portion 204 in the reagent storage well 200 through a transmission mechanism such as a gear and a cam.
Several configurations of the conduit 207 within the first reagent reservoir 7 are described below:
(first embodiment)
FIG. 2 is a view showing the direction A-A of the first reagent library of FIG. 1 according to the first embodiment of the present invention.
The conduit 207 has a plurality of conduit layers in the height direction of the side surface of the reagent reservoir tank 200. The guide tube 207 may be plural or may be one. When the conduit 207 is plural, the plural conduits are arranged along the side surface of the reagent reservoir tank 200 in the height direction, and the respective conduits at different positions in the height direction form respective conduit layers in the height direction of the conduit 207; when the guide tube 207 is one, one guide tube is arranged to extend spirally along the side surface of the reagent reservoir tank 200 in the height direction of the reagent reservoir tank 200, whereby the respective guide tube layers in the height direction of the guide tube 207 are formed by one guide tube.
As shown in fig. 2, the respective conduit layers of the conduit 207 are arranged parallel to each other with respect to the height direction of the side surface of the reagent reservoir tank 200. With this configuration, the conduit is disposed along the side surface of the reagent reservoir tank 200, and a refrigerant (for example, a liquid such as water or a gas) is caused to flow through the conduit, whereby the inside of the reagent reservoir can be uniformly and efficiently cooled.
Further, in the present embodiment, the conduit 207 is configured in the following manner: in the height direction of the side surface of the reagent reservoir tank 200, the interval between the plurality of conduit layers disposed at the higher position is smaller than the interval between the plurality of conduit layers disposed at the lower position. For example, in fig. 2, the conduits are arranged such that the density of conduit layers is increased in a region B which is a higher position in the height direction of the side surface of the reagent reservoir tank 200 and the interval between adjacent conduit layers is smaller than the interval between adjacent conduit layers in a region other than the region B.
In general, in order to open the reagent storage lid 202 when the reagent vessel 6 is stored in the reagent storage groove 200 and in order to suck out the reagent from the reagent vessel 6 by the first reagent dispensing arm 14 in a state where the first reagent storage 7 is covered with the reagent storage lid 202, a hole is formed in the reagent storage lid 202 near the reagent suction port of the reagent vessel 6, whereby it is difficult to maintain a cooling effect (uniform cooling) in a higher region (region close to the reagent storage lid 202) of the side surface of the reagent storage groove 200 in the first reagent storage 7 than in a lower region (region close to the bottom of the reagent storage groove 200) of the side surface of the reagent storage groove 200 in the first reagent storage 7. In the present embodiment, since the conduits are arranged such that the density of the conduit layers is increased in a higher position, i.e., in the region B, and the interval between adjacent conduit layers is smaller than the interval between adjacent conduit layers in the region other than the region B in the height direction of the side surface of the reagent reservoir tank 200, the cooling effect of the higher region of the side surface of the reagent reservoir tank 200 in the first reagent reservoir 7 (the region close to the reagent reservoir cover 202) is higher than the cooling effect of the lower region of the side surface of the reagent reservoir tank 200 in the first reagent reservoir 7 (the region close to the bottom of the reagent reservoir tank 200), and therefore, it is possible to suppress the temperature rise of the region close to the reagent reservoir cover 202 due to the opening and closing of the reagent reservoir cover 202 and the like, and maintain the uniformity of the cooling.
Further, when the guide tube 207 is viewed from above in fig. 2, the guide tube 207 is disposed in a region covering a part of the side surface of the reagent reservoir tank 200 in the circumferential direction of the side surface of the reagent reservoir tank 200. That is, the guide tube 207 is formed in a circular arc shape in the circumferential direction of the side surface of the reagent reservoir tank 200 as viewed in the height direction of the side surface of the reagent reservoir tank 200, whereby the manufacturing cost of the guide tube can be reduced. In order to achieve a better cooling effect, the duct 207 should be disposed in a region having a length of at least 90% of the circumferential direction of the side surface of the reagent reservoir tank 200.
In addition, when the conduit 207 is constituted by an arrangement in which one conduit extends spirally along the side surface of the reagent reservoir groove 200 in the height direction of the reagent reservoir groove 200, the conduit 207 is formed in a spiral shape in the circumferential direction of the side surface of the reagent reservoir groove 200 as viewed in the height direction of the side surface of the reagent reservoir groove 200, and at this time the conduit 207 is arranged in the region of the entire length of the side surface of the reagent reservoir groove 200 in the circumferential direction.
In addition, the guide tube 207 may be formed in a circular shape along the circumferential direction of the side surface of the reagent reservoir tank 200. In this case, the guide tube 207 is disposed over the entire circumferential length of the side surface of the reagent reservoir tank 200.
That is, the conduit 207 has at least one of a circular shape, a spiral shape, or a circular arc shape in the circumferential direction of the side surface of the reagent reservoir tank 200, and is arranged at least in a region of 90% or more of the length of the side surface of the reagent reservoir tank 200 in the circumferential direction.
(second embodiment)
FIG. 3 is a view showing the direction A-A of the first reagent kit of FIG. 1 according to the second embodiment of the present invention.
The conduit 207 has a plurality of conduit layers in the height direction of the side surface of the reagent reservoir tank 200. The guide tube 207 may be plural or may be one. When the conduit 207 is plural, the plural conduits are arranged along the side surface of the reagent reservoir tank 200 in the height direction, and the respective conduits at different positions in the height direction form respective conduit layers in the height direction of the conduit 207; when the guide tube 207 is one, one guide tube is arranged to extend spirally along the side surface of the reagent reservoir tank 200 in the height direction of the reagent reservoir tank 200, whereby the respective guide tube layers in the height direction of the guide tube 207 are formed by one guide tube.
As shown in fig. 3, the respective conduit layers of the conduit 207 are arranged parallel to each other with respect to the height direction of the side surface of the reagent reservoir tank 200. With this configuration, the conduit is disposed along the side surface of the reagent storage tank, and the refrigerant is caused to flow through the conduit, whereby the inside of the reagent storage tank can be uniformly and efficiently cooled.
Further, in the present embodiment, there are positions on the side surface of the reagent reservoir tank 200 where the temperature is susceptible to external factors, for example, the wiring and the through hole 301 for the sensor formed between the outside and the inside of the reagent reservoir tank 200, and the through hole 301 is explained below as an example:
around the through hole 301, a sub-duct 302 is disposed as a branch of the duct 207, that is, the duct layer of the duct 207 adjacent to the through hole 301 formed on the side surface of the reagent reservoir tank 200 forms the sub-duct 302 as a branch thereof.
Such a through hole 301 also passes through the heat insulating portion 201, and the air in the first reagent reservoir 7 is in contact with the outside air through the through hole 301, and therefore the cooling effect near the through hole 301 is poor. In the present embodiment, the sub-pipe 302, which is a branch of the pipe 207, is formed and arranged around the through-hole 301, and the refrigerant is also circulated in the sub-pipe 302, whereby the flow field area where the refrigerant flows around the through-hole 301 can be increased, the cooling effect in the vicinity of the through-hole 301 can be improved, and the temperature rise in the vicinity of the through-hole 301 can be suppressed to maintain the uniformity of cooling.
(third embodiment)
FIG. 4 is a view showing the direction A-A of the first reagent kit in FIG. 1 according to the third embodiment of the present invention.
The conduit 207 has a plurality of conduit layers in the height direction of the side surface of the reagent reservoir tank 200. The guide tube 207 may be plural or may be one. When the conduit 207 is plural, the plural conduits are arranged along the side surface of the reagent reservoir tank 200 in the height direction, and the respective conduits at different positions in the height direction form respective conduit layers in the height direction of the conduit 207; when the guide tube 207 is one, one guide tube is arranged to extend spirally along the side surface of the reagent reservoir tank 200 in the height direction of the reagent reservoir tank 200, whereby the respective guide tube layers in the height direction of the guide tube 207 are formed by one guide tube.
As shown in fig. 4, the respective conduit layers of the conduit 207 are arranged parallel to each other with respect to the height direction of the side surface of the reagent reservoir tank 200. With this configuration, the conduit is disposed along the side surface of the reagent storage tank, and the refrigerant is caused to flow through the conduit, whereby the inside of the reagent storage tank can be uniformly and efficiently cooled.
Further, in the present embodiment, there are positions on the side surface of the reagent reservoir tank 200 where the temperature is susceptible to external factors, for example, the wiring and the through hole 301 for the sensor formed between the outside and the inside of the reagent reservoir tank 200, and the through hole 301 is explained below as an example:
a bent conduit pipe portion 401 formed in the conduit layer of the conduit 207 adjacent to the through hole 301 in the height direction along the side surface of the reagent reservoir tank 200, and the bent conduit pipe portion 401 is arranged in the vicinity of the through hole 301.
Such a through hole 301 also passes through the heat insulating portion 201, and the air in the first reagent reservoir 7 is in contact with the outside air through the through hole 301, and therefore the cooling effect near the through hole 301 is poor. In the present embodiment, by disposing the bent conduit portion 401 of the conduit 207 in the vicinity of the through hole 301 and circulating the refrigerant through the bent conduit portion 401, the flow field area where the refrigerant flows around the through hole 301 can be enlarged, the cooling effect in the vicinity of the through hole 301 can be improved, and the temperature rise in the vicinity of the through hole 301 can be suppressed to maintain the uniformity of cooling.
(fourth embodiment)
FIG. 6 is a view showing the direction A-A of the first reagent kit in FIG. 1 according to the fourth embodiment of the present invention.
The conduit 207 has a first portion 303 and a second portion 304 which are arranged in the height direction of the side surface of the reagent reservoir tank 200 and independently complete the refrigerant cycle, and each of the first portion 303 and the second portion 304 has a plurality of conduit layers, and as described with reference to fig. 6, taking an example in which the first portion 303 is arranged in the upper half of the side surface of the reagent reservoir tank and the second portion 304 is arranged in the lower half of the side surface of the reagent reservoir tank, the first portion 303 and the second portion 304 are arranged in the height direction of the reagent reservoir tank 200 so as to extend spirally along the side surface of the reagent reservoir tank 200, and thereby the first portion 303 and the second portion 304 form each conduit layer in the height direction of the side surface of the reagent reservoir tank.
Since the cold air has a relatively high specific gravity and is generally located at a lower position in the reagent storage well 200, the temperature of the upper position of the reagent storage well 200 is higher than that of the lower position thereof, and therefore, the pipe diameter of the first portion 303 near the upper position (i.e., the position near the reagent storage lid 202) is set to be larger than the pipe diameter of the second portion 304 near the bottom position of the reagent storage well 200, so that the temperature inside the reagent storage well 200 can be kept relatively uniform from top to bottom.
The respective conduit layers of the first portion 303 and the second portion 304 are arranged parallel to each other with respect to the height direction of the side surface of the reagent reservoir tank 200. The refrigerants independently circulate in the first portion 303 and the second portion 304, and two independent refrigerant circulations are formed at the upper position and the lower position of the side surface of the reagent storage tank 200, so that the interior of the first reagent storage 7 can be effectively kept cold, and the pipe diameter of the first portion 303 can be set to be larger than that of the second portion 304 according to the temperature difference between the upper position and the lower position of the reagent storage tank 200, so that the surface area of the first portion 303 at the upper position is larger, and the cold keeping effect is improved.
In addition, the distribution of the individual conduit layers of the first portion 303 may be arranged more densely than the second portion 304. It is also possible to provide different refrigerants in first portion 303 and second portion 304 such that the cooling effect of first portion 303 is higher in the upper position than the cooling effect of second portion 304 in the lower position.
(fifth embodiment)
FIG. 7 is a view showing the direction A-A of the first reagent kit in FIG. 1 according to the fifth embodiment of the present invention.
Since the temperature at the opening for reagent introduction is high, the conduit is configured to have the first portion 303 and the second portion 304 which are alternately arranged in the height direction of the side surface of the reagent reservoir tank 200 and independently complete the refrigerant circulation, the first portion 303 and the second portion 304 each have a plurality of conduit layers, the conduit diameter of the first portion 303 is larger than that of the second portion 304, the first portion 303 having a larger conduit diameter can be used when the temperature is high, and the second portion 304 having a smaller conduit diameter can be used when the temperature is low.
Wherein, the first portion 303 and the second portion 304 each have a plurality of conduit layers, the first portion 303 and the second portion 304 are arranged to extend spirally along the side surface of the reagent reservoir groove 200 in the height direction of the reagent reservoir groove 200, thereby the first portion 303 and the second portion 304 respectively form each conduit layer in the height direction of the side surface of the reagent reservoir groove, and the conduit layers of the first portion 303 and the second portion 304 are arranged to stagger at the side surface of the reagent reservoir groove 200, for example, the following layers are arranged in order from top to bottom at the side surface of the reagent reservoir groove: the conduit layers of first portion 303, second portion 304, first portion 303, and second portion 304.
The respective conduit layers of the first portion 303 and the second portion 304 are arranged parallel to each other with respect to the height direction of the side surface of the reagent reservoir tank 200. The refrigerants independently circulate in the first portion 303 and the second portion 304, two independent refrigerant circulations are formed on the entire side surface of the reagent reservoir tank 200, and the refrigerant circulations of the first portion 303 and the second portion 304 are selectively used according to the temperature change in the first reagent reservoir 7, whereby the cooling effect can be effectively improved.
(sixth embodiment)
FIG. 8 is a view showing the direction A-A of the first reagent kit in FIG. 1 according to the sixth embodiment of the present invention.
The conduit 207 has a plurality of conduit layers in the height direction of the side surface of the reagent reservoir tank 200. The guide tube 207 may be plural or may be one. When the conduit 207 is plural, the plural conduits are arranged along the side surface of the reagent reservoir tank 200 in the height direction, and the respective conduits at different positions in the height direction form respective conduit layers in the height direction of the conduit 207; when the guide tube 207 is one, one guide tube is arranged to extend spirally along the side surface of the reagent reservoir tank 200 in the height direction of the reagent reservoir tank 200, whereby the respective guide tube layers in the height direction of the guide tube 207 are formed by one guide tube.
As shown in fig. 8, the respective conduit layers of the conduit 207 are arranged parallel to each other with respect to the height direction of the side surface of the reagent reservoir tank 200. With this configuration, the conduit is disposed along the side surface of the reagent storage tank 200, and the refrigerant flows through the conduit, so that the inside of the reagent storage tank can be uniformly and efficiently cooled.
Since there is a place where the sealing or heat insulation is insufficient (i.e., a place where the temperature is susceptible to external factors) inside the reagent reservoir tank 200, for example, the wiring between the outside and the inside of the reagent reservoir tank 200 and the through hole 301 for the sensor are formed on the side surface of the reagent reservoir tank 200, the air inside the reagent reservoir tank 200 may contact with the outside air through the through hole 301, resulting in poor cold insulation near the through hole 301.
Therefore, in the present embodiment, at least a part of the conduit layer has the expanded portion 305 having a larger diameter than the conduit layer itself, and the expanded portion 305 is disposed at a position on the side surface of the reagent reservoir tank where the temperature is susceptible to external factors (for example, in the vicinity of the through hole 301 described above), and by such a configuration, the flow field area of the refrigerant flowing around the through hole 301 can be enlarged, thereby enhancing the cooling effect in the vicinity of the through hole 301. The expanding portion 305 is formed by expanding the volume of the guide tube 207 partially outward to have a tube structure larger than the tube diameter of the guide tube 207.
(seventh embodiment)
FIG. 9 is a view showing the direction A-A of the first reagent kit in FIG. 1 according to the seventh embodiment of the present invention.
The conduit 207 has a plurality of conduit layers in the height direction of the side surface of the reagent reservoir tank 200. The guide tube 207 may be plural or may be one. When the conduit 207 is plural, the plural conduits are arranged along the side surface of the reagent reservoir tank 200 in the height direction, and the respective conduits at different positions in the height direction form respective conduit layers in the height direction of the conduit 207; when the guide tube 207 is one, one guide tube is arranged to extend spirally along the side surface of the reagent reservoir tank 200 in the height direction of the reagent reservoir tank 200, whereby the respective guide tube layers in the height direction of the guide tube 207 are formed by one guide tube.
As shown in fig. 9, the respective conduit layers of the conduit 207 are arranged parallel to each other with respect to the height direction of the side surface of the reagent reservoir tank 200. With this configuration, the conduit is disposed along the side surface of the reagent reservoir tank, and the refrigerant is made to flow through the conduit 207, whereby the inside of the first reagent reservoir 7 can be uniformly and efficiently cooled.
Since there is a place where the sealing or heat insulation is insufficient (i.e., a place where the temperature is susceptible to external factors) inside the reagent reservoir tank 200, for example, the wiring between the outside and the inside of the reagent reservoir tank 200 and the sensor through hole 301 are formed on the side surface of the reagent reservoir tank 200, the air inside the reagent reservoir tank 200 may contact with the outside air through the through hole 301, and the cooling effect near the through hole 301 is poor.
Therefore, in this embodiment, at least a part of the surface of the conduit pipe is provided with the extension piece 306 which deforms by absorbing energy, and the extension piece 306 is disposed at a position (for example, the through hole 301 described above) on the side surface of the reagent reservoir tank 200 where the temperature is susceptible to external factors, and when the local temperature rises, the extension piece 306 deforms by absorbing heat and spreads to the outside of the conduit pipe, thereby increasing the surface area of the conduit pipe, increasing the cooling effect, and improving the cooling effect near the through hole 301.
The extension piece 306 is also arranged at a position on the side surface of the reagent reservoir well 200 where the light is susceptible to external factors (for example, near the open part of the reagent reservoir lid), and when the light is bright at the open part of the reagent reservoir lid, the extension piece 306 deforms and expands to the outside of the conduit layer, thereby increasing the surface area of the conduit and increasing the cooling effect, and improving the cooling effect near the through-hole 301.
If the cross-section of the conduit 207 is polygonal, the spreader 306 may be glued or welded directly to a flat surface of the conduit. If a conduit having a circular or oval cross-section is used, it is not convenient to fix the extending piece 306, and the extending piece 306 can be fixed by a clamping member, and then the clamping member is fixed outside the conduit 207 by a screw nut.
The extension sheet 306 is a structure made of deformable functional material, and is generally a sheet-like structure, such as a heat-sensitive metal sheet and a light-sensitive deformable material. And the extension piece 306 is partially fixed to the guide tube 207.
(eighth embodiment)
FIG. 10 is a view showing the direction A-A of the first reagent kit in FIG. 1 according to the eighth embodiment of the present invention.
The conduit 207 has a plurality of conduit layers in the height direction of the side surface of the reagent reservoir tank 200. The guide tube 207 may be plural or may be one. When the conduit 207 is plural, the plural conduits are arranged along the side surface of the reagent reservoir tank 200 in the height direction, and the respective conduits at different positions in the height direction form respective conduit layers in the height direction of the conduit 207; when the guide tube 207 is one, one guide tube is arranged to extend spirally along the side surface of the reagent reservoir tank 200 in the height direction of the reagent reservoir tank 200, whereby the respective guide tube layers in the height direction of the guide tube 207 are formed by one guide tube.
As shown in fig. 10, the respective conduit layers of the conduit 207 are arranged parallel to each other with respect to the height direction of the side surface of the reagent reservoir tank 200. With this configuration, the conduit is disposed along the side surface of the reagent storage tank, and the refrigerant is caused to flow through the conduit, whereby the inside of the reagent storage tank can be uniformly and efficiently cooled.
Since there is a place where the sealing or heat insulation is insufficient (i.e., a place where the temperature is susceptible to external factors) inside the reagent reservoir tank 200, for example, the wiring between the outside and the inside of the reagent reservoir tank 200 and the through hole 301 for the sensor are formed on the side surface of the reagent reservoir tank 200, the air inside the reagent reservoir tank 200 may contact with the outside air through the through hole 301, resulting in poor cold insulation near the through hole 301.
Therefore, in this embodiment, at least a part of the pipe layers have a cross pipe network 307, the cross pipe network 307 is a network structure composed of a plurality of branch pipes, and the refrigerant can flow in each branch pipe. The cross pipe network 307 is configured to be disposed at a position on a side surface of the reagent reservoir tank where temperature is susceptible to external factors, a temperature sensor for monitoring abnormal temperature is disposed on an inner wall of the reagent reservoir tank on a peripheral side of the cross pipe network 307, electromagnetic valves are disposed at least a plurality of cross nodes on the cross pipe network 307, the electromagnetic valves on the cross nodes realize adjustment of different execution states according to temperature data acquired by the temperature sensor, and the cross pipe network 307 forms a plurality of different refrigerant flow paths according to different execution states of the electromagnetic valves.
The present embodiment further includes at least a control means, and the control means may be the analysis control unit 2 itself of the automatic analysis device, and the position (high risk position) detected by each temperature sensor corresponds to the refrigerant flow path of one kind of the cross pipe network 307, that is, corresponds to the open/close state of all the electromagnetic valves on one kind of the cross pipe network 307; when the temperature sensor acquires abnormal temperature data (the detected position is called as an abnormal point), the corresponding electromagnetic valve is opened, so that the refrigerant flows through the refrigerant flow path of the abnormal point to achieve the purpose of temperature reduction.
As shown in fig. 12, there is provided a control flow chart of a refrigerant flow path,
s1, starting;
s2: initializing a system;
S3:n=1,M1=M2=…=Mawhen the electromagnetic valve is not electrified, the flow path is closed
S4: reading the temperature sample value tn
S5:tn≤Tn
S6:Mn=0;
S7:Mn=Mn+1;
S8:Mn≤b;
S9: the nth refrigerant flow path electromagnetic valve is not electrified;
s10: the nth refrigerant flow path electromagnetic valve is electrified and opened;
S11:n=n+1;
S12:n≤a;
S13:n=1。
thus, it can be seen that:
setting the number of the temperature sensors as a, each temperature sensor corresponds to one refrigerant flow path, and recording the continuous temperature out-of-tolerance number of the nth temperature sensor as MnNote that each temperature sensor allows the number of consecutive temperature overshoots to be b (b > 0).
In the initial state, the electromagnetic valve is not electrified, the refrigerant flow path is closed, and the temperature sensor monitors the temperature data of the corresponding temperature monitoring point in real time.
When the nth temperature sensor reads the temperature sampling value tnA reference temperature value T smaller than the nth temperature sensornWhen M is in contact withnThe solenoid valve corresponding to the nth refrigerant flow path is not energized.
When the temperature sampling value t read by the nth temperature sensor is larger than the comparison reference temperature value Tn of the nth temperature sensor, Mn=Mn+1, and when Mn< b, the solenoid valve corresponding to the nth refrigerant flow path is not energized, when MnWhen the number "b" is larger, the solenoid valve corresponding to the nth refrigerant flow path is energized.
And after the temperature out-of-tolerance condition of the nth temperature sensor at the corresponding position in the reagent library groove is judged, the temperature out-of-tolerance condition of the n +1 temperature sensors at the corresponding position in the reagent library groove is continuously judged until all the temperature data collected by the a temperature sensors are analyzed.
When the temperature data collected by the a temperature sensors are completely analyzed, the analysis is started from the beginning.
In the embodiment, the temperature exceeding of the same temperature detection point is continuously determined for b times to confirm that the temperature detection point is a high risk point, and a countermeasure (opening a corresponding refrigerant flow path) can be taken only after the temperature exceeding of the same temperature detection point is determined to be the high risk point, so that the phenomenon of over-low local temperature caused by misjudgment of the high risk point is avoided.
(ninth embodiment)
Fig. 5 is a schematic view of the bottom of the first reagent kit of fig. 1 according to the ninth embodiment of the present invention.
The guide tube 207 is disposed at the bottom of the reagent reservoir tank, and the entire guide tube 207 is disposed in a radial structure.
The conduit 207 at the bottom of the reagent well may be disposed simultaneously with the conduit 207 at the side surface of the reagent well (any one of the first to ninth embodiments may be used) or may be disposed independently (the conduit 207 may be disposed only at the bottom of the reagent well).
Since the drain opening 502 and the transmission part 503 at the bottom of the reagent storage well also pass through the heat insulating part 201, the air in the first reagent storage 7 is in contact with the outside air through the drain opening 502 and the transmission part 503, and therefore the cooling effect in the vicinity of the drain opening 502 and the transmission part 503 is poor.
In order to improve the cooling efficiency, the heat radiation fins 501 are provided on the duct 207, and the distribution density of the heat radiation fins 501 is increased in the vicinity of the drain opening 502 and/or the transmission part 503 formed in the bottom part 500 of the reagent reservoir tank 200 having a high possibility of contact with such outside air, or a single heat radiation fin 501 is provided (i.e., the heat radiation fins 501 are provided separately).
By forming such a structure, it is possible to improve the cooling effect in the vicinity of the bottom 500 of the reagent reservoir tank 200 (a lower region in the height direction of the side surface of the reagent reservoir tank 200) and to maintain the uniformity of cooling by suppressing temperature rise.
(tenth embodiment)
Fig. 13 is a schematic view showing the arrangement of a catheter on a reagent cartridge cover according to a tenth embodiment of the present invention.
The conduit 207 is disposed inside the reagent reservoir cover 202, the conduit 207 may be disposed in a circular configuration as a whole, and the conduit 207 has a plurality of conduit layers radially distributed from the outer periphery to the center of the reagent reservoir cover 202, wherein the conduit 207 on the reagent reservoir cover 202 may be disposed simultaneously with the conduit 207 on the side surface of the reagent reservoir well and the bottom of the reagent reservoir well (may be disposed in any one of the first to ninth embodiments), or may be disposed independently (the conduit 207 is disposed only on the reagent reservoir cover 202).
Since dew is formed on the surface of the conduit 207, the conduit 207 is not disposed at a position above the opening of the reagent container 6 in order to prevent the dew from falling into the reagent container 6.
(eleventh embodiment)
FIG. 11 is a view showing the direction A-A of the first reagent kit in FIG. 1 according to the eleventh embodiment of the present invention.
Since there is a place where the sealing or heat insulation is insufficient (i.e., a place where the temperature is susceptible to external factors) inside the reagent reservoir tank 200, for example, the wiring between the outside and the inside of the reagent reservoir tank 200 and the through hole 301 for the sensor are formed on the side surface of the reagent reservoir tank 200, the air inside the reagent reservoir tank 200 may contact with the outside air through the through hole 301, resulting in poor cold insulation near the through hole 301. For another example, the cooling effect is also relatively poor in the vicinity of the drain port 502 and the transmission part 503 at the bottom of the reagent reservoir tank 200.
Therefore, the fan 308 and the temperature sensor are disposed inside the reagent reservoir tank, and both the fan 308 and the temperature sensor are disposed near the positions (such as the through hole 301, the drain opening 502, and the transmission part 503) on the inner wall of the reagent reservoir tank where the temperature is susceptible to the external factors, so that the local temperature reduction is achieved by increasing the wind speed to improve the heat exchange efficiency.
The present embodiment also generally includes a control component, and the control component may be the analysis control part 2 of the automatic analysis device, when the temperature sensor detects that the temperature of the high risk position is higher than the set standard value, the control component starts the fan 308 of the high risk position to realize cooling, and when the temperature sensor detects that the temperature of the high risk position is not higher than the set standard value, the fan 308 is turned off or the rotation speed of the fan 308 is reduced.
While several embodiments of the present invention have been described, these embodiments have been presented by way of example only, and are not intended to limit the scope of the invention. These new embodiments can be implemented in other various ways, and various omissions, substitutions, combinations, and changes can be made without departing from the spirit of the invention. These embodiments and modifications are included in the scope and gist of the present invention, and are included in the present invention and the equivalent scope thereof described in the claims.

Claims (34)

1. An automatic analyzer is characterized by comprising:
a sample dispensing arm that dispenses a test sample from a sample container containing the test sample into a reaction container;
a reagent dispensing arm that dispenses a reagent from a reagent container containing the reagent into the reaction container;
a photometric unit configured to perform photometry on the mixed solution in the reaction container; and
a reagent reservoir having: a reagent storage tank for storing the reagent container; a reagent reservoir cover covering the reagent reservoir groove; a conduit disposed along a wall surface of the reagent reservoir tank; a cooling section for cooling the refrigerant; and a flow pump connected to a start end and a finish end of the conduit to flow the refrigerant in the conduit.
2. The automatic analysis device according to claim 1,
the conduit has at least one of a circular shape, a spiral shape, or a circular arc shape in a circumferential direction of a side surface of the reagent reservoir well.
3. The automatic analyzer according to claim 1, wherein the guide tube is disposed in at least a region having a length of 90% or more in a circumferential direction of a side surface of the reagent reservoir groove.
4. The automatic analysis device according to claim 1,
the conduit has a plurality of conduit layers in a height direction of a side surface of the reagent reservoir tank, the plurality of conduit layers are arranged in parallel to each other with respect to the height direction of the side surface of the reagent reservoir tank, and an interval of the plurality of conduit layers arranged at a higher position is smaller than an interval of the plurality of conduit layers arranged at a lower position in the height direction of the side surface of the reagent reservoir tank.
5. The automatic analysis device according to claim 1,
the conduit has a plurality of conduit layers in a height direction of a side surface of the reagent reservoir tank, the conduit layer adjacent to a through hole formed on the side surface of the reagent reservoir tank forms a sub conduit as a branch thereof, and the sub conduit is arranged around the through hole.
6. The automatic analysis device according to claim 1,
the duct has a plurality of duct layers in a height direction of a side surface of the reagent reservoir tank, the duct layer adjacent to a through hole formed on the side surface of the reagent reservoir tank forms a curved duct portion curved in the height direction, and the curved duct portion is arranged in the vicinity of the through hole.
7. The automatic analysis device according to claim 1,
the conduit is provided with a first part and a second part which are arranged in the height direction of the side surface of the reagent storage groove and independently complete refrigerant circulation, and the first part and the second part are provided with a plurality of conduit layers, wherein the first part is arranged at the position of the side surface of the reagent storage groove close to the reagent storage cover, the second part is arranged at the position of the side surface of the reagent storage groove close to the groove bottom, and the pipe diameter of the first part is larger than that of the second part.
8. The automatic analysis device according to claim 1,
the guide pipe is provided with a first part and a second part which are distributed in a staggered manner in the height direction of the side surface of the reagent storage groove and independently complete refrigerant circulation, the first part and the second part are both provided with a plurality of guide pipe layers, and the pipe diameter of the first part is larger than that of the second part.
9. The automatic analysis device according to claim 1,
the conduit is provided with a plurality of conduit layers in the height direction of the side surface of the reagent storage groove, at least part of the conduit layers are provided with expansion parts which are larger than the pipe diameters of the conduit layers, and the expansion parts are used for being arranged at positions on the side surface of the reagent storage groove, wherein the temperature of the positions is easily influenced by the outside.
10. The automatic analysis device according to claim 1,
the guide pipe is provided with a plurality of guide pipe layers in the height direction of the side surface of the reagent reservoir groove, and at least part of the surface of the guide pipe layer is provided with an extension sheet which deforms by absorbing energy; and the extension piece is used for being arranged at a position on the side surface of the reagent storage groove, wherein the temperature of the position is easily influenced by the outside.
11. The automated analyzer of claim 1, wherein the extension strip is a thermally sensitive bi-metallic strip.
12. The automatic analyzer according to claim 1, wherein the conduit has a plurality of conduit layers in a height direction of a side surface of the reagent reservoir tank, at least a part of the conduit layers has a cross pipe network for arranging a position on the side surface of the reagent reservoir tank where a temperature is susceptible to an external factor, a temperature sensor for monitoring an abnormal temperature is provided on an inner wall of the reagent reservoir tank on a peripheral side of the cross pipe network, and electromagnetic valves are provided on at least a plurality of cross nodes on the cross pipe network, the electromagnetic valves on the cross nodes realize adjustment of different execution states according to temperature data obtained by the temperature sensor, and the cross pipe network forms a plurality of different refrigerant flow paths according to the different execution states of the electromagnetic valves.
13. The automatic analysis device according to claim 1,
the reagent storage tank is internally provided with a fan and a temperature sensor, and the fan and the temperature sensor are both arranged at the position where the internal temperature of the reagent storage tank is easily influenced by external factors.
14. The automatic analysis device according to any one of claims 1 to 13,
a guide pipe is arranged at the bottom of the reagent reservoir tank, and the whole guide pipe is arranged in a radial structure.
15. The automatic analysis device according to claim 14,
the guide pipe is provided with a radiating fin, and the distribution density of the radiating fin at the position where the temperature at the bottom of the reagent storage groove is easily influenced by external factors is greater than that of the radiating fins at other positions at the bottom of the reagent storage groove.
16. The automatic analysis device according to any one of claims 1 to 13,
a conduit is arranged on the inner side of the reagent storage cover, the conduit is integrally arranged in a circular structure, and the conduit is provided with a plurality of conduit layers which are radially distributed from the periphery to the center of the reagent storage cover.
17. The automatic analysis device according to claim 1, comprising:
a holding unit that holds the reagent container stored in the reagent storage well;
a drive mechanism for rotating the holding portion;
a heat sink disposed at the bottom of the reagent reservoir tank;
a water discharge port formed at the bottom of the reagent reservoir tank for discharging dew in the reagent reservoir; and
a transmission part formed at the bottom of the reagent reservoir tank and transmitting the power of the driving mechanism to the holding part;
the heat dissipation fins are provided in the vicinity of the drain port or the transmission portion so as to increase the density of the heat dissipation fins or to be provided separately.
18. A reagent storage of an automatic analyzer is characterized by comprising:
a reagent storage tank for storing reagent containers for storing reagents used for analysis by the automatic analyzer;
a reagent reservoir cover covering the reagent reservoir groove;
a conduit disposed along a wall surface of the reagent reservoir tank;
a cooling unit that cools the refrigerant; and
a flow pump connected to a start end and a finish end of the conduit and flowing the refrigerant in the conduit.
19. The reagent storage of an automatic analyzer according to claim 18,
the conduit has at least one of a circular shape, a spiral shape, or a circular arc shape in a circumferential direction of a side surface of the reagent reservoir well.
20. The reagent cartridge of the automatic analyzer according to claim 18, wherein the conduit is disposed in at least a region of 90% or more of the length of the side surface of the reagent cartridge groove in the circumferential direction.
21. The reagent storage of an automatic analyzer according to claim 18,
the conduit has a plurality of conduit layers in a height direction of a side surface of the reagent reservoir tank, the plurality of conduit layers are arranged in parallel to each other with respect to the height direction of the side surface of the reagent reservoir tank, and an interval of the plurality of conduit layers arranged at a higher position is smaller than an interval of the plurality of conduit layers arranged at a lower position in the height direction of the side surface of the reagent reservoir tank.
22. The reagent storage of an automatic analyzer according to claim 18,
the conduit has a plurality of conduit layers in a height direction of a side surface of the reagent reservoir tank, the conduit layer adjacent to a through hole formed on the side surface of the reagent reservoir tank forms a sub conduit as a branch thereof, and the sub conduit is arranged around the through hole.
23. The reagent storage of an automatic analyzer according to claim 18,
the duct has a plurality of duct layers in a height direction of a side surface of the reagent reservoir tank, the duct layer adjacent to a through hole formed on the side surface of the reagent reservoir tank forms a curved duct portion curved in the height direction, and the curved duct portion is arranged in the vicinity of the through hole.
24. The reagent storage of an automatic analyzer according to claim 18,
the conduit is provided with a first part and a second part which are arranged in the height direction of the side surface of the reagent storage groove and independently complete refrigerant circulation, and the first part and the second part are provided with a plurality of conduit layers, wherein the first part is arranged at the position of the side surface of the reagent storage groove close to the reagent storage cover, the second part is arranged at the position of the side surface of the reagent storage groove close to the groove bottom, and the pipe diameter of the first part is larger than that of the second part.
25. The reagent storage of an automatic analyzer according to claim 18,
the guide pipe is provided with a first part and a second part which are distributed in a staggered manner in the height direction of the side surface of the reagent storage groove and independently complete refrigerant circulation, the first part and the second part are both provided with a plurality of guide pipe layers, and the pipe diameter of the first part is larger than that of the second part.
26. The reagent storage of an automatic analyzer according to claim 18,
the conduit is provided with a plurality of conduit layers in the height direction of the side surface of the reagent storage groove, at least part of the conduit layers are provided with expansion parts which are larger than the pipe diameters of the conduit layers, and the expansion parts are used for being arranged at positions on the side surface of the reagent storage groove, wherein the temperature of the positions is easily influenced by the outside.
27. The reagent storage of an automatic analyzer according to claim 18,
the guide pipe is provided with a plurality of guide pipe layers in the height direction of the side surface of the reagent storage tank, at least part of the surface of the guide pipe layer is provided with an extension sheet which deforms by absorbing energy, and the extension sheet is used for being arranged at a position on the side surface of the reagent storage tank, wherein the temperature of the position is easily influenced by the outside.
28. The reagent storage of an automatic analyzer according to claim 27, wherein the extension strip is a thermosensitive bimetal strip.
29. The reagent storage of an automatic analyzer according to claim 18, wherein the tubes have a plurality of tube layers in a height direction of a side surface of the reagent storage tank, at least some of the tube layers have a cross pipe network for arranging a position on the side surface of the reagent storage tank where a temperature is susceptible to an external factor, a temperature sensor for monitoring an abnormal temperature is provided on an inner wall of the reagent storage tank on a peripheral side of the cross pipe network, and electromagnetic valves are provided at least a plurality of cross nodes on the cross pipe network, the electromagnetic valves on the cross nodes realize adjustment of different execution states according to temperature data obtained by the temperature sensor, and the cross pipe network forms a plurality of different refrigerant flow paths according to different execution states of the electromagnetic valves.
30. The reagent storage of an automatic analyzer according to claim 18,
the reagent storage tank is internally provided with a fan and a temperature sensor, and the fan and the temperature sensor are both arranged at the position where the internal temperature of the reagent storage tank is easily influenced by external factors.
31. The reagent storage of an automatic analyzer according to any of claims 18 to 30,
a guide pipe is arranged at the bottom of the reagent reservoir tank, and the whole guide pipe is arranged in a radial structure.
32. The reagent storage of an automatic analyzer according to claim 31,
the guide pipe is provided with a radiating fin, and the distribution density of the radiating fin at the position where the temperature at the bottom of the reagent storage groove is easily influenced by external factors is greater than that of the radiating fins at other positions at the bottom of the reagent storage groove.
33. The reagent storage of an automatic analyzer according to any of claims 18 to 30,
a conduit is arranged on the inner side of the reagent storage cover, the conduit is integrally arranged in a circular structure, and the conduit is provided with a plurality of conduit layers which are radially distributed from the periphery to the center of the reagent storage cover.
34. The reagent pool of the automatic analyzer according to claim 18, comprising:
a holding unit that holds the reagent container stored in the reagent storage well;
a drive mechanism for rotating the holding portion;
a heat sink disposed at the bottom of the reagent reservoir tank;
a water discharge port formed at the bottom of the reagent reservoir tank and discharging dew in the reagent reservoir; and
a transmission part formed at the bottom of the reagent reservoir tank and transmitting the power of the driving mechanism to the holding part;
wherein the heat radiating fins are provided in the vicinity of the drain port or the transmission portion so as to increase the density of the heat radiating fins or so as to be provided separately.
CN202010833986.6A 2019-10-28 2020-08-18 Automatic analyzer and reagent library thereof Pending CN112730277A (en)

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