CN112691077B - Processing method of glucose injection - Google Patents

Abstract

The invention discloses a processing method of a glucose injection, the glucose injection comprises a fat-soluble medicine and a capsule wall material, and the capsule wall material comprises the following components in parts by weight: 15-45 parts of sodium alginate, 1882.5-9 parts of poloxamer, 1.5-5 parts of silk fibroin, 0.5-3 parts of polyvinyl alcohol and 0.2-3 parts of polyethylene glycol, wherein the glucose accounts for 5% of the total volume by mass; the fat-soluble medicine is zedoary turmeric oil, vitamin E or coenzyme Q10, the weight portion is 15-45 portions, and the processing method comprises the following steps: preparing a sodium alginate aqueous solution, a silk fibroin aqueous solution and a polyvinyl alcohol aqueous solution; mixing a sodium alginate aqueous solution, a silk fibroin aqueous solution, a polyvinyl alcohol aqueous solution and glucose by using a mixing device to obtain a mixed solution A; adding poloxamer and polyethylene glycol into the mixed solution A, uniformly mixing, and finally dropwise adding a fat-soluble medicine to obtain a mixed solution B; treating with ultrasound and shearing, filtering with 450nm membrane, and sterilizing with damp heat to obtain glucose injection.

Description

A kind of processing method of glucose injection

technical field

The invention belongs to the technical field of pharmaceutical preparations, and in particular relates to a processing method of glucose injection.

Background technique

Lipid-soluble drugs have significant pharmacological activity, the active ingredients are prone to oxidative deterioration and affect the drug properties, and the solubility in the human body environment is low, so it is difficult to achieve the effective concentration of the drug. Therefore, solubilizers are commonly used in clinical practice to improve the stability and solubility of fat-soluble drugs, and at the same time achieve targeting, improve drug bioavailability, and reduce toxic side effects.

When the bilayer membrane liposome is used as a water-soluble drug delivery system, there is still the problem of thermodynamic instability, but when it is applied to lipid-soluble drugs, it is a single-layer membrane, and the stability becomes extremely poor. Poloxamer has good biocompatibility but poor stability, and Tween-80 is the main application in clinical lipid-soluble drug injection, but it has a high risk of hemolysis, which limits the scope of drug use and drug concentration . At present, there is a lack of injection preparations with high safety, high stability and high drug loading in the market. Therefore, it is particularly important to find a safer, more stable and high drug loading preparation method for lipid-soluble drug injection preparations.

SUMMARY OF THE INVENTION

In order to overcome the deficiencies of the prior art, the present invention provides a processing method of glucose injection.

In order to achieve the above purpose, the present invention adopts the following technical scheme: a method for processing glucose injection, the glucose injection comprises a fat-soluble drug and a capsule material, and the capsule material is in parts by weight: 15-45 parts of sodium alginate, polox 2.5-9 parts of sham, 1.5-5 parts of silk fibroin, 0.5-3 parts of polyvinyl alcohol, and 0.2-3 parts of polyethylene glycol; the fat-soluble drug is curcuma oil, vitamin E or coenzyme Q10, and its weight parts It is 15 to 45 parts; it also includes 5% of the mass of the total volume of glucose, including the following steps:

Step a: preparing an aqueous solution of sodium alginate, an aqueous solution of silk fibroin and an aqueous solution of polyvinyl alcohol; step b: mixing the aqueous solution of sodium alginate, the aqueous solution of silk fibroin, the aqueous solution of polyvinyl alcohol and glucose through a mixing device to obtain a mixed solution A;

Step c: adding poloxamer and polyethylene glycol to the mixed solution A, after uniform mixing, and finally adding the fat-soluble drug dropwise to obtain the mixed solution B;

Step d: Ultrasonic and shearing are used for processing, 450nm membrane filtration, and moist heat sterilization to obtain glucose injection;

Wherein the mixing device in step b includes a neutralizing and mixing pump, a mixing sleeve matched with the neutralizing and mixing pump, and a third connecting pipe connecting the neutralizing and mixing pump and the first feeding pipe, and the mixing sleeve There are four layers, and the sodium alginate aqueous solution, the silk fibroin aqueous solution, the polyvinyl alcohol aqueous solution and the glucose are sequentially supplied from the outside to the inside; the mixing sleeve includes a first tube body and a second tube body arranged in the first tube body. , The third tube body set in the second tube body, the fourth tube body set in the third tube body, the multiple groups of the first hole groups set on the second tube body, the multiple sets of the first hole set set on the third tube body a second hole group, a plurality of groups of third hole groups arranged on the fourth pipe body, a first shunt assembly arranged at the first hole group at the head end, a second flow shunt assembly arranged at the second hole group at the head end, a third splitter assembly located at the third hole group at the head end, a first baffle and a second baffle between the first pipe body and the second pipe body, and the second pipe body and the third pipe body The third partition, the fourth partition, the fifth partition and the sixth partition between the third and fourth tubes, the seventh partition, the eighth partition and the ninth partition plate and the tenth partition plate, the adjacent two groups of first hole groups are symmetrically arranged, and the first hole groups are composed of a plurality of first arc holes arranged in an equidistant annular distribution on the second pipe body; A partition plate is provided, so that the sodium alginate aqueous solution located between the first pipe body and the second pipe body enters between the second pipe body and the third pipe body through the first hole group at the head end, and is connected with the second pipe body and the third pipe body. The silk fibroin aqueous solution in the three tubes is mixed, and the sodium alginate aqueous solution and the silk fibroin aqueous solution are quickly mixed through the first shunt component at the head end, and the two are mixed through the third separator, and then enter the first end through the second hole group at the head end. Between the third pipe body and the fourth pipe body, it is mixed with the polyvinyl alcohol aqueous solution in the third pipe body and the fourth pipe body. The three are quickly mixed, and the three are mixed through the seventh separator and then enter the fourth tube through the third hole group at the head end, mixed with the glucose in the fourth tube, and the sodium alginate aqueous solution, silk fibroin The protein aqueous solution, the polyvinyl alcohol aqueous solution and the glucose are rapidly mixed, and after the four are mixed, they return to between the fourth tube body and the third tube body through the third hole group adjacent to the third hole group at the first end, and pass through the first tube body in turn. The second hole group adjacent to the second hole group at the end and the first hole group adjacent to the first hole group at the head end enter between the third pipe body and the second pipe body and between the first pipe body and the second pipe body in turn. In between, the first hole group, the second hole group and the third hole group are provided with a plurality of, and the sodium alginate aqueous solution, the silk fibroin aqueous solution, the polyvinyl alcohol aqueous solution and the The four glucoses are mixed, and after mixing, they go back and forth between the first tube body and the second tube body, between the second tube body and the third tube body, between the third tube body and the fourth tube body, and in the fourth tube body. , so as to prolong the flow length of the mixing of the four, so that the effect of the mixing and neutralization of the four is better, and then the mixing pump is used for further mixing.

Preferably, the mixing sleeve further comprises a plurality of first rod bodies which are arranged in an equidistant annular distribution through the second partition and one end is fixedly arranged on the first partition, and are arranged in an equidistant annular distribution through the fourth partition. and a plurality of second rod bodies, one end of which is fixed on the third partition board, and the fifth partition board and the sixth partition board, and the equidistant annular distribution runs through the eighth partition board, the ninth partition board and the tenth partition board. And one end is fixed on a plurality of third rod bodies on the seventh partition board; the sodium alginate aqueous solution, silk fibroin aqueous solution and polyvinyl alcohol aqueous solution entering between the first tube body and the second tube body are set by the first rod body and glucose for shunting, which has a good mixing effect. The sodium alginate aqueous solution, silk fibroin aqueous solution, polyvinyl alcohol aqueous solution and glucose entering between the second tube body and the third tube body are separated by the setting of the second rod body. , play a very good mixing effect, through the setting of the third rod body, the sodium alginate aqueous solution, silk fibroin aqueous solution, polyvinyl alcohol aqueous solution and glucose entering between the fourth tube body and the third tube body are shunted, which plays a very important role in shunting. A good mixing effect, that is, the sodium alginate aqueous solution, the silk fibroin aqueous solution, the polyvinyl alcohol aqueous solution and the glucose flow through multiple shunt mixing can greatly improve the mixing efficiency and effect, and there is no need to pause during the mixing process.

Preferably, the mass fraction of the sodium alginate aqueous solution is 0.5%-2.0%, the mass fraction of the silk fibroin aqueous solution is 0.5%-2%, and the mass fraction of the polyvinyl alcohol aqueous solution is 0.5%-2%.

Preferably, the first flow distribution component includes a first conical plate, a first cavity provided in the first conical plate, a plurality of first water outlet pipes arranged in an equidistant annular distribution on the first conical plate, a plurality of second water outlet pipes running through the first conical plate, a first fixing ring fixed on the inner wall of the second pipe, a plurality of distribution plates fixed on the first fixing ring in an equidistant annular distribution, A first through hole located in the middle of the distribution plate; the sodium alginate aqueous solution enters the first cavity in the first conical plate through a plurality of first arc holes, and passes through a plurality of first water outlet pipes on the first cavity The discharge enters between the second pipe body and the third pipe body, and the silk fibroin aqueous solution between the second pipe body and the third pipe body is discharged from a plurality of second water outlet pipes, and the first conical plate is arranged so that the inner The flow rate of the sodium alginate aqueous solution discharged from the first water outlet pipe outside the channel increases in turn, so that the silk fibroin aqueous solution discharged from the second water outlet pipe from the outside of the inner channel increases in turn. A vortex is formed to improve the mixing effect of the two, and then the two flow to both sides through a plurality of diverting plates, a part of which flows through the first through hole on it, and is mixed with the two mixed through the adjacent diverting plates. The staggered arrangement of the first water outlet pipe and the second water outlet pipe can greatly improve the mixing effect of the two.

Preferably, the third flow distribution assembly includes a rotating shaft disposed at the axis of the fourth pipe body, a first sleeve fixedly sleeved on the rotating shaft, rotatably sleeved on the rotating shaft and fixedly disposed on the inner wall of the fourth pipe The second shaft sleeve, the second fixed ring fixed on the inner wall of the fourth tube, the second through hole set in the middle of the second fixed ring, the vortex-shaped concentrator fixed on the rotating shaft, the fixed sleeve A circular plate on the rotating shaft, a plurality of inclined plates arranged on the vortex-shaped collecting plate at equal intervals, a third through hole located on one end of the inclined plate on the vortex-shaped collecting plate, and a third through hole located on the other end of the inclined plate on the vortex-shaped collecting plate. The fourth through hole on the converging plate; the rotating shaft is driven to rotate by the neutralization mixing pump, so that the vortex converging plate on the rotating shaft rotates, and the glucose in the fourth tube passes between the fourth tube and the circular plate, and passes through the The three mixtures of sodium alginate aqueous solution, silk fibroin aqueous solution and polyvinyl alcohol aqueous solution entered into the third hole group, the four mixtures flow to the middle of the vortex concentrator during the rotation process, from the third hole in the middle of the fixed ring. The two through holes flow in the direction of the first bushing, so that the four can be gathered and mixed, and the four can change the direction of their flow through the arrangement of a plurality of inclined plates on it, and the overall mixing effect is very good. and the fourth through hole can reduce the resistance during the rotation of the vortex collecting plate, and can also make the four mixed materials flow through the third through hole and the fourth through hole, and improve the position of the third through hole and the fourth through hole. The flow speed of the rotating shaft can be increased to improve the mixing effect at the place. The arrangement of the first bushing and the second bushing can make the rotation process of the rotating shaft more stable, reduce the shaking during the rotation process, and improve the service life of the rotating shaft. After the concentrators gather, they flow from the second through hole to the direction of the first bushing, and then pass through the first bushing and then divide the flow of the four, that is, the four are first subjected to converging and impact mixing, and then the four are divided, which greatly improves the The mixing effect and efficiency of the four are obtained.

Preferably, the first shaft sleeve comprises a sleeve body, a first conical body fixed on one end of the sleeve body, a fixed plate fixed on the first conical body in an equidistant annular distribution, and a driven plate rotatably disposed on the fixed plate a shaft, a second conical body fixedly sleeved on the driven shaft, a hollow tube fixedly sleeved on the driven shaft, a plurality of fifth through holes and sixth through holes arranged in an equidistant annular distribution on the hollow tube, A conical ring is fixed on one end of the hollow tube; during the rotation of the rotating shaft, the first shaft sleeve is driven to rotate, the sleeve body rotates, and the first conical body rotates, so that the plurality of fixed plates on the first conical body take the rotating shaft as the axis During the revolution, the four-component mixture flowing through the place can be made to flow outward through the setting of the first conical body. During the flow process, a part directly enters the hollow tube, and a part enters the hollow tube through the fifth through hole, so as to make the The mixture of the four is impacted and mixed, and the mixture in the hollow tube is discharged through the sixth through hole, and flows through the second cone, and is divided outward again. The tube can be rotated to make it easier to mix the four mixtures in it, and a part of the mixture in the hollow tube will flow out from the other fifth through holes, which can reduce the resistance during the revolution of the hollow tube. The group is more fully mixed as it flows through it.

To sum up, the lipid-soluble drug submicrocapsule glucose injection is a stable system, the solution is clear and transparent after centrifugation, without delamination or suspension, the submicrocapsule system is evenly packaged, and the submicrocapsule particle size is uniform; The capsule material poloxamer is safe and non-toxic, and can effectively improve the uniformity and stability of the microcapsules; it solves the technical problems of low safety, poor stability and low drug loading of the existing fat-soluble drug submicrocapsules. The raw materials of the prepared glucose injection are more evenly mixed, so that the compatibility with blood is good, and the above-mentioned problem of the above-mentioned safer, more stable and high drug-loading fat-soluble glucose injection is better solved.

Description of drawings

FIG. 1 is a cross-sectional view of the present invention.

FIG. 2 is an enlarged view of part A in FIG. 1 .

FIG. 3 is an enlarged view of B in FIG. 1 .

FIG. 4 is a partial cross-sectional view taken along the line B-B in FIG. 1 .

FIG. 5 is a partial cross-sectional view taken along line C-C in FIG. 1 .

FIG. 6 is a partial cross-sectional view taken along the line D-D in FIG. 1 .

FIG. 7 is a cross-sectional view taken along the line E-E in FIG. 1 .

FIG. 8 is a cross-sectional view taken along the line F-F in FIG. 1 .

FIG. 9 is an enlarged view of C in FIG. 8 .

FIG. 10 is a schematic structural diagram of the second pipe body.

Detailed ways

As shown in Figure 1-10, a method for processing a glucose injection, the glucose injection includes a fat-soluble drug and a capsule material, and the capsule material is by weight: 15-45 parts of sodium alginate, 2.5-45 parts of poloxamer 9 parts, 1.5 to 5 parts of silk fibroin, 0.5 to 3 parts of polyvinyl alcohol, and 0.2 to 3 parts of polyethylene glycol; the fat-soluble drug is curcuma oil, vitamin E or coenzyme Q10, and its parts by weight are 15 to 45 parts by weight servings; also including 5% of the mass of the total volume of glucose, including the following steps:

Step a: preparing an aqueous solution of sodium alginate, an aqueous solution of silk fibroin and an aqueous solution of polyvinyl alcohol; step b: mixing the aqueous solution of sodium alginate, the aqueous solution of silk fibroin, the aqueous solution of polyvinyl alcohol and glucose through a mixing device to obtain a mixed solution A;

Step c: adding poloxamer and polyethylene glycol to the mixed solution A, after uniform mixing, and finally adding the fat-soluble drug dropwise to obtain the mixed solution B;

Step d: Ultrasonic and shearing are used for processing, 450nm membrane filtration, and moist heat sterilization to obtain glucose injection;

The mixing device in step b includes a neutralizing and mixing pump 11, a mixing sleeve 12 matched with the neutralizing and mixing pump, and a third connecting pipe 13 connecting the neutralizing and mixing pump and the first feeding pipe. The mixing sleeve is provided with four layers, and sequentially supplies sodium alginate aqueous solution, silk fibroin aqueous solution, polyvinyl alcohol aqueous solution and glucose from the outside to the inside; the mixing sleeve 12 includes a first tube body 121, which is arranged in the first tube body. The second tube body 122, the third tube body 123 set in the second tube body, the fourth tube body 124 set in the third tube body, the plurality of first hole groups 125 set on the second tube body, the Multiple groups of second hole groups 126 on the third pipe body, multiple groups of third hole groups 127 located on the fourth pipe body, first shunt components 128 located at the first hole group at the head end, The second shunt assembly 129 at the second hole group at the end, the third shunt assembly 130 located at the third hole group at the head end, the first partition 131 and the second Two partition plates 132, a third partition plate 133, a fourth partition plate 134, a fifth partition plate 135 and a sixth partition plate 136 arranged between the second tube body and the third tube body, The seventh partition plate 137, the eighth partition plate 138, the ninth partition plate 139 and the tenth partition plate 140 between the fourth pipe bodies are symmetrically arranged in the adjacent two groups of the first hole groups, and the first hole groups are arranged symmetrically. It is composed of a plurality of first arc holes 141 which are arranged on the second pipe body in an equidistant annular distribution; set through the first partition plate, so that the sodium alginate aqueous solution located between the first pipe body and the second pipe body passes through the first pipe body. The first hole group at the end enters between the second tube body and the third tube body, and mixes with the silk fibroin aqueous solution in the second tube body and the third tube body. The protein aqueous solution is quickly mixed, and the two are mixed through the third partition, and then enter between the third and fourth tubes through the second hole group at the head end, and the polyvinyl alcohol in the third and fourth tubes. The aqueous solution is mixed, and the sodium alginate aqueous solution, the silk fibroin aqueous solution and the polyvinyl alcohol aqueous solution are quickly mixed through the second shunt component at the head end, and the three are mixed through the seventh separator and then enter the fourth through the third hole group at the head end. In the tube, it is mixed with the glucose in the fourth tube, and the sodium alginate aqueous solution, the silk fibroin aqueous solution, the polyvinyl alcohol aqueous solution and the glucose are rapidly mixed through the third shunt component. The adjacent third hole group goes back between the fourth pipe body and the third pipe body, and sequentially passes through the second hole group adjacent to the second hole group at the head end and the first hole group adjacent to the first hole group at the head end group, enter between the third pipe body and the second pipe body and between the first pipe body and the second pipe body in turn, the first hole group, the second hole group and the third hole group are provided with multiple, through the The first to tenth partitions make the sodium alginate aqueous solution, the silk fibroin aqueous solution, the polyvinyl alcohol aqueous solution and the glucose four mixed, and after mixing, they go back and forth between the first tube body and the second tube body, and the second tube body. Between the body and the third tube body, between the third tube body and the fourth tube body, and in the fourth tube body, so as to prolong the flow length of the mixing of the four, so that the effect of the mixing and neutralization of the four is better. mixing pump further step mix.

As shown in FIGS. 1 and 7 , the mixing sleeve 12 further includes a plurality of first rod bodies 142 equidistant annularly distributed through the second partition and one end fixed on the first partition. A plurality of second rod bodies 143 are arranged through the fourth, fifth and sixth partitions, and one end is fixed on the third partition, and are equally spaced and annularly distributed through the eighth and ninth partitions. A plurality of third rod bodies 144 on the separator and the tenth separator and one end is fixed on the seventh separator; the sodium alginate aqueous solution, The aqueous solution of silk fibroin, the aqueous solution of polyvinyl alcohol and glucose are divided, which has a good mixing effect. Diverted with polyvinyl alcohol aqueous solution and glucose, which has a good mixing effect, and the sodium alginate aqueous solution, silk fibroin aqueous solution and polyvinyl alcohol entering between the fourth pipe body and the third pipe body are set by the third rod body. The aqueous solution and the glucose are divided into different streams, which has a good mixing effect, that is, the sodium alginate aqueous solution, the silk fibroin aqueous solution, the polyvinyl alcohol aqueous solution and the glucose flow through several times of shunting and mixing, which can greatly improve the mixing efficiency and effect. There is no need to pause during mixing.

Preferably, the mass fraction of the sodium alginate aqueous solution is 0.5%-2.0%, the mass fraction of the silk fibroin aqueous solution is 0.5%-2%, and the mass fraction of the polyvinyl alcohol aqueous solution is 0.5%-2%.

As shown in FIGS. 2 and 4 , the first diverter assembly 128 includes a first conical plate 145 , a first cavity 146 disposed in the first conical plate, and is disposed on the first conical plate equidistantly and annularly. A plurality of first water outlet pipes 147, a plurality of second water outlet pipes 148 arranged through the first conical plate, a first fixing ring 149 fixed on the inner wall of the second pipe, equidistant annular distribution fixed on the A plurality of distribution plates 150 on the first fixing ring, a first through hole 151 located in the middle of the distribution plate; the sodium alginate aqueous solution enters the first cavity in the first conical plate through the plurality of first arc holes, It is discharged through the plurality of first water outlet pipes on the first cavity and enters between the second pipe body and the third pipe body, and the silk fibroin aqueous solution between the second pipe body and the third pipe body is discharged from the plurality of second pipe bodies. The water pipe is discharged, and the flow rate of the sodium alginate aqueous solution discharged from the first water outlet pipe from the outside of the inner channel increases sequentially through the setting of the first conical plate, so that the silk fibroin aqueous solution discharged from the second water outlet pipe from the outside of the inner channel increases in turn. A fixed ring is arranged so that the two are mixed to form a vortex, and the mixing effect of the two is improved, and then the two flow to both sides of the two through a plurality of distribution plates, and a part flows through the first through hole on it, and passes through the first through hole. The mixing of the two divided by the adjacent dividing plates touches and mixes, and the staggered arrangement of the first water outlet pipe and the second water outlet pipe can greatly improve the mixing effect of the two.

As shown in FIGS. 3 , 5 and 6 , the third diverter assembly 130 includes a rotating shaft 152 disposed at the axis of the fourth pipe body, a first sleeve 153 fixedly sleeved on the rotating shaft, and rotatably sleeved on the rotating shaft And the second shaft sleeve 154 fixed on the inner wall of the fourth tube, the second fixing ring 155 fixed on the inner wall of the fourth tube, the second through hole 156 at the middle of the second fixing ring, the A vortex-shaped collector plate 157 on the rotating shaft, a circular plate 158 fixedly sleeved on the rotation shaft, a plurality of inclined plates 159 arranged on the vortex-shaped collector plate at equal intervals, and one end of the inclined plate is arranged on the vortex-shaped collector plate. The third through hole 160 on the sloping plate and the fourth through hole 161 on the vortex collecting plate at the other end of the inclined plate; the rotating shaft is driven to rotate by the neutralization mixing pump, so that the vortex collecting plate on the rotating shaft rotates, the fourth The glucose in the tube passes between the fourth tube body and the circular plate, and is mixed with the sodium alginate aqueous solution, the silk fibroin aqueous solution and the polyvinyl alcohol aqueous solution that enter through the third hole group. In the middle, the mixture of the four components flows to the middle, and flows from the second through hole in the middle of the fixed ring to the direction of the first bushing, so that the four components are gathered and mixed. The direction of flow has a good mixing effect as a whole. Through the third through hole and the fourth through hole, the resistance received during the rotation of the vortex collector plate can be reduced, and the mixed material of the four can flow through the third through hole. and the fourth through hole, improve the flow speed at the third through hole and the fourth through hole, and improve the mixing effect there. Reduce the shaking during the rotation process and improve the service life of the rotating shaft. Concentrating and impacting mixing of the four, and then splitting the four, greatly improving the mixing effect and efficiency of the four.

As shown in Figures 3 and 9, the first shaft sleeve 153 includes a sleeve body 162, a first conical body 163 fixed on one end of the sleeve body, a fixed plate 164 fixed on the first conical body in an equidistant annular distribution, The driven shaft 165 rotatably arranged on the fixed plate, the second conical body 166 fixedly sleeved on the driven shaft, the hollow tube 167 fixedly sleeved on the driven shaft, the equidistant annularly arranged on the hollow tube A plurality of fifth through holes 168 and sixth through holes 169, and a conical ring 170 fixed on one end of the hollow tube; during the rotation of the rotating shaft, the first shaft sleeve is driven to rotate, so that the sleeve body rotates, and the first conical body rotates to make The plurality of fixed plates on the first cone revolve around the axis of rotation. The setting of the first cone can make the four-component mixture flowing there flow outward. During the flow process, part of the fixed plate directly enters the hollow tube, and the other part passes through. The fifth through hole enters the hollow tube, and is impacted and mixed with the four-component mixture directly entering the hollow tube. The mixture in the hollow tube is discharged through the sixth through hole, and flows through the second cone, and is divided outward again. , set on the fixed plate by the rotation of the driven shaft, so that the hollow tube can be rotated, so that the four mixtures located in it are easier to mix, and part of the mixture in the hollow tube will flow out from the other fifth through holes, which can reduce the hollowness of the hollow tube. The resistance received during the pipe revolution can make the four groups mix more comprehensively when passing through the hollow pipe revolution.

Claims (6)

1. A processing method of a glucose injection, the glucose injection comprises a fat-soluble drug and a capsule material, the capsule material by weight: 15-45 parts of sodium alginate, 2.5-9 parts of poloxamer, silk fibroin 1.5 to 5 parts, 0.5 to 3 parts of polyvinyl alcohol, and 0.2 to 3 parts of polyethylene glycol; the fat-soluble drug is curcuma oil, vitamin E or coenzyme Q10, and its weight part is 15 to 45 parts; The volume 5% of the mass of glucose, characterized in that: comprising the following steps: Step a: preparing an aqueous solution of sodium alginate, an aqueous solution of silk fibroin and an aqueous solution of polyvinyl alcohol; step b: mixing the aqueous solution of sodium alginate, the aqueous solution of silk fibroin, the aqueous solution of polyvinyl alcohol and glucose through a mixing device to obtain a mixed solution A; Step c: adding poloxamer and polyethylene glycol to the mixed solution A, after uniform mixing, and finally adding the fat-soluble drug dropwise to obtain the mixed solution B; Step d: Ultrasonic and shearing are used for processing, 450nm membrane filtration, and moist heat sterilization to obtain glucose injection; Wherein, the mixing device in step b comprises a neutralization mixing pump (11), a mixing sleeve (12) matched with the neutralization mixing pump and a third connecting pipe connecting the neutralization mixing pump and the first feeding pipe (13), the mixing sleeve is provided with four layers, and sequentially supplies sodium alginate aqueous solution, silk fibroin aqueous solution, polyvinyl alcohol aqueous solution and glucose from the outside to the inside; the mixing sleeve (12) includes a first pipe body (121), a second pipe body (122) provided in the first pipe body, a third pipe body (123) provided in the second pipe body, a fourth pipe body (124) provided in the third pipe body, Multiple groups of first hole groups (125) on the second pipe body, multiple groups of second hole groups (126) located on the third pipe body, multiple groups of third hole groups (126) located on the fourth pipe body 127), a first shunt assembly (128) arranged at the first hole group at the head end, a second shunt assembly (129) arranged at the second hole group at the head end, and a first shunt assembly (129) arranged at the third hole group at the head end. A three-split assembly (130), a first partition plate (131) and a second partition plate (132) arranged between the first pipe body and the second pipe body, and arranged between the second pipe body and the third pipe body The third partition plate (133), the fourth partition plate (134), the fifth partition plate (135) and the sixth partition plate (136), the seventh partition plate arranged between the third pipe body and the fourth pipe body The plate (137), the eighth separator (138), the ninth separator (139) and the tenth separator (140), the adjacent two groups of the first hole groups are symmetrically arranged, and the first hole groups are composed of etc. It is composed of a plurality of first arc-shaped holes (141) distributed annularly on the second pipe body; set by the first partition plate, so that the sodium alginate aqueous solution located between the first pipe body and the second pipe body passes through the first The first hole group at the end enters between the second tube body and the third tube body, and mixes with the silk fibroin aqueous solution in the second tube body and the third tube body. The protein aqueous solution is quickly mixed, and the two are mixed through the third partition, and then enter between the third and fourth tubes through the second hole group at the head end, and the polyvinyl alcohol in the third and fourth tubes. The aqueous solution is mixed, and the sodium alginate aqueous solution, the silk fibroin aqueous solution and the polyvinyl alcohol aqueous solution are quickly mixed through the second shunt component at the head end, and the three are mixed through the seventh separator and then enter the fourth through the third hole group at the head end. In the tube, it is mixed with the glucose in the fourth tube, and the sodium alginate aqueous solution, the silk fibroin aqueous solution, the polyvinyl alcohol aqueous solution and the glucose are rapidly mixed through the third shunt component. The adjacent third hole group goes back between the fourth pipe body and the third pipe body, and sequentially passes through the second hole group adjacent to the second hole group at the head end and the first hole group adjacent to the first hole group at the head end group, and enter between the third tube body and the second tube body and between the first tube body and the second tube body in sequence. 2. The processing method of a kind of glucose injection according to claim 1, it is characterized in that: described mixing sleeve (12) also comprises equidistant annular distribution and is arranged on the second partition board and one end is fixedly arranged on the first A plurality of first rod bodies (142) on a partition, a plurality of first rods (142) equidistant annularly distributed through the fourth partition, the fifth partition and the sixth partition, and one end of which is fixed on the third partition Two rod bodies (143), a plurality of third rod bodies (144), which are distributed in an equidistant and annular manner through the eighth, ninth and tenth partitions, and one end is fixed on the seventh partition; The arrangement of a rod body makes the sodium alginate aqueous solution, the aqueous solution of silk fibroin, the aqueous solution of polyvinyl alcohol and the glucose that enter between the first pipe body and the second pipe body to be shunted, and the second rod body is arranged to enter the second pipe body and the third pipe body. The sodium alginate aqueous solution, silk fibroin aqueous solution, polyvinyl alcohol aqueous solution and glucose between the tubes are divided, and the sodium alginate aqueous solution, silk fibroin solution entering between the fourth tube body and the third tube body is set by the third rod body The protein aqueous solution, the polyvinyl alcohol aqueous solution and the glucose were split. 3. The processing method of a kind of glucose injection according to claim 1, it is characterized in that: sodium alginate aqueous solution mass fraction is 0.5%～2.0%, silk fibroin aqueous solution mass fraction is 0.5%～2%, polyethylene The mass fraction of the alcohol aqueous solution is 0.5% to 2%. 4. The processing method of a glucose injection according to claim 1, characterized in that: the first shunt assembly (128) comprises a first conical plate (145), a A first cavity (146), a plurality of first water outlet pipes (147) arranged in an equidistant annular distribution on the first conical plate, and a plurality of second water outlet pipes (148) arranged through the first conical plate , a first fixing ring (149) fixed on the inner wall of the second pipe, a plurality of shunt plates (150) arranged in an equidistant annular distribution and fixed on the first fixing ring, and a first channel set in the middle of the shunt plate Holes (151); the sodium alginate aqueous solution enters the first cavity in the first conical plate through a plurality of first arc-shaped holes, and enters the second pipe after being discharged through a plurality of first water outlet pipes on the first cavity Between the second pipe body and the third pipe body, the silk fibroin aqueous solution between the second pipe body and the third pipe body is discharged from a plurality of second water outlet pipes, and is discharged from the first water outlet pipe from the outside of the inner channel through the setting of the first conical plate. The flow rate of the sodium alginate aqueous solution increases successively, so that the silk fibroin aqueous solution discharged from the second water outlet pipe from the outside of the inner channel increases successively, and is set through the first fixed ring so that the two here are mixed to form a vortex, and then pass through a plurality of The dividing plate makes the two flow to its two sides, and a part flows through the first through hole on it, and touches and mixes with the mixture of the two that is divided by the adjacent dividing plate. 5. The processing method of a glucose injection according to claim 1, wherein the third shunt assembly (130) comprises a rotating shaft (152) arranged at the axis of the fourth pipe body, a fixed sleeve A first sleeve (153) on the rotating shaft, a second sleeve (154) rotatably sleeved on the rotating shaft and fixed on the inner wall of the fourth tube, and a second fixed sleeve on the inner wall of the fourth tube a ring (155), a second through hole (156) arranged in the middle of the second fixing ring, a vortex collector plate (157) fixedly arranged on the rotating shaft, a circular plate (158) fixedly sleeved on the rotating shaft, A plurality of inclined plates (159) are arranged on the vortex-shaped collector plate at equal intervals, a third through hole (160) is located on one end of the inclined plate and is arranged on the vortex-shaped collector plate, and the other end of the inclined plate is arranged on the vortex-shaped collector plate. The fourth through hole (161) on the flow plate; the rotating shaft is driven to rotate by the neutralization mixing pump, so that the vortex-shaped concentrating plate on the rotating shaft rotates, and the glucose in the fourth tube passes between the fourth tube body and the circular plate, It is mixed with the sodium alginate aqueous solution, the silk fibroin aqueous solution and the polyvinyl alcohol aqueous solution entering through the third hole group. During the rotation of the vortex gathering plate, the four mixtures flow to the middle, from the middle of the fixed ring. The second through hole of the duct flows in the direction of the first bushing, so that the four are gathered and mixed. 6. The method for processing a glucose injection according to claim 5, wherein the first shaft sleeve (153) comprises a sleeve body (162), a first conical body (162) that is fixedly arranged at one end of the sleeve body 163), a fixed plate (164) fixedly arranged on the first conical body in an equidistant annular distribution, a driven shaft (165) rotatably arranged on the fixed plate, and a second conical body (165) fixedly sleeved on the driven shaft 166), a hollow tube (167) fixedly sleeved on the driven shaft, a plurality of fifth through holes (168) and sixth through holes (169) arranged in an equidistant annular distribution on the hollow tube, fixed on the hollow tube A conical ring (170) at one end of the tube; during the rotation of the rotating shaft, the first shaft sleeve is driven to rotate, so that the sleeve body rotates, and the first conical body rotates, so that the plurality of fixed plates on the first conical body are rotated with the rotating shaft as the axis. Revolving, through the setting of the first cone, the four-component mixture flowing there can flow outward. During the flow process, a part directly enters the hollow tube, and a part enters the hollow tube through the fifth through hole, so that the four components that directly enter the hollow tube are connected with each other. The mixture is impacted and mixed, and the mixture in the hollow tube is discharged through the sixth through hole, and flows through the second cone, and is divided outward again. It can be rotated to make it easier to mix the four mixtures in it, and part of the mixture in the hollow tube will flow out from the other fifth through holes.

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