CN1125638C - Stable delayed vitamin C preparation and its production process - Google Patents
Stable delayed vitamin C preparation and its production process Download PDFInfo
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- CN1125638C CN1125638C CN99113722A CN99113722A CN1125638C CN 1125638 C CN1125638 C CN 1125638C CN 99113722 A CN99113722 A CN 99113722A CN 99113722 A CN99113722 A CN 99113722A CN 1125638 C CN1125638 C CN 1125638C
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Abstract
The present invention discloses a stable slow release vitamin C preparation and a production method thereof. The stable slow release vitamin C preparation is prepared from vitamin C, a solvent and a polymer colloid material, wherein the weight ratio of the vitamin C to the polymer colloid material is 1: 0.02 to 0.2. After the vitamin C is micronized, the polymer colloid material is used as a framework and is used as an inclusion agent to carry out inclusion, and the preparation is prepared through granulation and drying. The present invention has the advantages of unique formula and making method, stability and slow release.
Description
The present invention relates to a kind of stable delayed vitamin C preparation, especially relate to a kind of stable delayed vitamin C preparation that is used for aquatic feeds, the invention still further relates to the production method of said preparation.
It is that body is kept homergy and the necessary low molecular compound of physiological function that the L-ascorbic acid is commonly called as vitamin C (Vc).Growing along with herding and aquatic products industry, the increasing substantially of poultry, the Aquatic product level of production, the batch production of feeding manner, intensification, it is especially playing immeasurable effect in culture fishery as a kind of feed additive of trophism.
Most of fish and shrimp and shellfish can not biosynthesis Vc, must absorb from food.In Fish, the feedstuff as when lacking Vc, it is protruding that anorexia, poor growth, lordosis or side then take place, fin, epidermis, hemorrhage of muscle, and the lower jaw erosion, hemorrhagic eyeball protrusion etc., and gill rot, red squama disease etc. can take place.When lacking Vc in the prawn feed, then poor growth, shell is soft, molting frequency reduces, produce eperythrozoonosis, black and white pinta even cause large tracts of land death.So Vc is the vitamin that aquatic feeds must add.
But because Vc is influenced by light, heat, oxygen, humidity, metallic element etc., in feedstuff processing and storage process, be very susceptible to damage, lose physiologically active.Vc is a water soluble vitamins, and in the bait input water that is added with Vc, Vc will be dissolved in rapidly in the water, and is very fast oxidized.Thereby guarantee to take at the ascorbic acid of available sufficient amount biologically be difficult.The Vc that increases general type according to the doubled amount of recommendation is difficult to not only definitely guarantee that aquatic animal takes in the Vc of available sufficient amount, and the feed price costliness, the aquaculture cost height, and have potential pollution.
For this reason, stable type Vc is all being sought to develop in countries in the world.The domestic and international research achievement shows, 1. the stable main method of Vc is had wrap by Vc with ethyl cellulose or fat etc.; 2. make the derivant of Vc with chemical method.The technology of using ethyl cellulose to clad Vc has the history of more than ten years, does not improve the stability of Vc but the ethyl cellulose bag has been greatly diminished flowability.According to data introduction [Feed International, 1991, (10): 6-10], the Vc of ethyl cellulose bag quilt is quite thin at the thickness of the outstanding position of core grain (locating as edge, turning point etc.) coatings, coatings very easily takes place break, the stamen material is exposed, and in the grinding and processing process, peplos is easier to break, and the retention rate of Vc is less than 40% after the feedstuff extrusion modling.Cladding Vc is because crystal has corner angle, bag by the time edges and corners be difficult for cladding fully, so still can very fast dissolving in aqueous solution.
The fat bag is used to improve the stability of ascorbic acid the earliest, but any high-temperature process (granulation, extruding, steaming and decocting) all can be melted fat.And crystal can expose once more and Oxidation takes place, and fat also can be oxidized, thereupon just by autoxidation and transmission deoxidation Vc[feed industry, 1999, (3): 34-36].
With the ascorbic acid derivates of chemosynthesis, synthetic process conditions are harsh, and equipment investment is bigger, and production cost is higher.
The object of the present invention is to provide a kind of stable delayed vitamin C preparation of not only having had stability but also a tool slow-releasing, said preparation can be used for the supplement feed of domestic animal, poultry, particularly aquatic animal.
Another object of the present invention provides the production method of this stable delayed vitamin C preparation.
Solution of the present invention is to adopt special formulation and technology, developed a kind of stable delayed vitamin C preparation, it is made up of crystallization vitamin C or powdery vitamin C, solvent and polymer colloid material, with the polymer colloid material is skeleton, and be inclusion agents with the polymer colloid material, vitamin C is carried out the hydrophilic gel preparation that enclose, granulation, drying are made, and vitamin C is 1 with the ratio of the weight of polymer colloid material: 0.02-0.2.Said preparation is met aqueous medium, with the colloid of aqueous medium intersection owing to hydration is gel, form stiff gel barrier together on every side, ten minutes has been avoided the influence of external factor to Vc effectively, has also hindered the very fast molten mistake of Vc.
Vitamin C of the present invention is 1 with the preferred ratio of polymer colloid material: 0.02-0.2.
Stable delayed vitamin C preparation of the present invention can be a graininess or Powdered.
Production method of the present invention is:
1. vitamin C and polymer colloid material are fully mixed stirring in Hi-mixer,
Make vitamin C adhere to the polymer colloid material;
2. the polymer colloid material is dissolved in and makes colloid solution in the solvent;
3. colloid solution is added dropwise in the blender, vitamin C is carried out enclose, make microgranule,
Place baking oven to dry then.
The present invention adds solvent and the vitamin C mix homogeneously that sticks on the polymer colloid material in Hi-mixer, granulate with comminutor, and oven dry is sprayed on the microgranule of making the drying while spraying then with colloid solution.
Polymer colloid material of the present invention is selected from synthetic or semisynthetic colloidal materials such as hydroxypropyl cellulose, carboxymethyl cellulose and sodium salt thereof, polyvinylpyrrolidone, polyamide, also can be selected from natural materials such as sodium alginate, gelatin, agar, arabic gum, tragacanth.The vitamin C that the present invention adopts is the L-ascorbic acid, or the metal cation salt of ascorbic acid, or the ester of producing with following acid and the derivant of these esters, as phosphoric acid, acetic acid, sulphuric acid, fatty acid etc.
Solvent of the present invention is ethanol, water, or other organic solvent.
Important feature of the present invention is stable delayed vitamin C preparation slowly stripping in water of adopting this special formulation and technology to make, has reduced the molten mistake that bait drops into Vc in the water; Can slowly discharge in animal body, make the Vc in the animal body blood keep stable concentration, participate in the vivo oxidation reduction reaction continuously, avoid producing peak valley phenomenon; Have good cladding performance, very avoided external factor (as light, heat, oxygen, humidity, metallic element etc.) effectively, and can protect the physiologically active of Vc thus well ascorbic influence; Have good flowability, can mix with other uniform ingredients in the feedstuff; The capsulating material and the processing technology that adopt can make the peplos on Vc surface not be destroyed, and when mixing with other feedstuff, the adding condition is unrestricted; Vc retention rate height in the feedstuff course of processing and feed storage process.
Feedstuff course of processing Vc retention test: produce 2 tons of pellet production lines when experimental facilities is, the premix blender is the 50kg capacity, and the production line blender is the 500kg capacity, and granulator brewing chamber curing temperature is 86 ℃.A lot number is produced the 250kg pellet.Adopt high performance liquid chromatography to detect ascorbic acid content in the feedstuff.Result such as following table:
| Sample | Content (%) | Powder content (mg/kg) | Granule content (mg/kg) | Vc retention rate (%) |
| Sample | 94.64 | 733 | 677 | 92.36 |
| Contrast | 99.62 | 939 | 620 | 66.03 |
Annotate: matched group is common Vc
The Vc destructive testing of feed storage: at high temperature (37-40 ℃), high humidity (RH75%), deposited 15 days under the mal-condition that has metal ion (Fe) to exist, carried out destructive testing, adopt high performance liquid chromatography to detect ascorbic acid content in the feedstuff.Result such as following table:
Annotate: matched group is common Vc
Release test in the water: the intelligent digestion instrument of experimental apparatus ZRS-4, Tianjin, island Uv-260 ultraviolet spectrophotometer, survey release in the water, by commentaries on classics blue laws Revolution Per Minute 50 commentaries on classics of 95 editions Chinese Pharmacopoeia drug release determination methods, result such as following table:
The Vc preparation that the present invention produces can be used for the supplement feed of domestic animal, poultry, particularly aquatic animal, and detailed directions gets final product by the recommendation adding of the addition of the required Vc of animal.
Embodiment 1
Take by weighing vitamin C (pharmaceutical grade) 1000 grams, add hydroxypropyl cellulose 50 grams, in Hi-mixer, mixed 20 minutes; With hydroxypropyl cellulose 4 gram, be dissolved in 400 milliliters of 50% alcoholic solution, make colloid solution; This colloid solution is added dropwise in the blender, carries out the enclose pelletize, put below 50 ℃ and dry in the baking oven.Get finished product 1000 grams.
Embodiment 2
Take by weighing vitamin C (pharmaceutical grade) 1000 grams, add carboxymethyl cellulose 200 grams, in Hi-mixer, mixed 30 minutes, add 300 milliliters of 70% alcoholic solution, continue to mix 10 minutes, make 60 purpose microgranules, put below 60 ℃ and dry in the baking oven with comminutor.Get finished product 1140 grams.
Embodiment 3
Take by weighing vitamin C (pharmaceutical grade) 1000 grams, add sodium alginate 90 grams, put in the blender and mixed 20 minutes, add 300 milliliters of 60% alcoholic solution, continue to mix 15 minutes, make 60 purpose microgranules, put oven dry below 50 ℃ in the baking oven, put in the coating pan with comminutor.With sodium alginate 10 gram, be dissolved in 1000 milliliters of 60% alcoholic solution and make colloid solution, this solution is sprayed in the coating pan drying while spraying.Get finished product 995 grams.
Claims (6)
1. stable delayed vitamin C preparation that is used for aquatic feeds, it is characterized in that by vitamin C, solvent and polymer colloid material are formed, with the polymer colloid material is skeleton, and be inclusion agents with the polymer colloid material, vitamin C is carried out enclose, granulate, the preparation that drying is made, vitamin C is 1 with the ratio of the weight of polymer colloid material: 0.02-0.2, and wherein the polymer colloid material is selected from hydroxypropyl cellulose, carboxymethyl cellulose, sodium carboxymethyl cellulose, sodium alginate, polyvinylpyrrolidone, polyamide, gelatin, agar, any one of arabic gum.
2. stable delayed vitamin C preparation according to claim 1 is characterized in that the vitamin C and the ratio of the weight of corresponding polymer colloid material are 1: 0.05-0.1.
3. stable delayed vitamin C preparation according to claim 1 is characterized in that described preparation is a graininess or Powdered.
4. the production method of stable delayed vitamin C preparation according to claim 1, this method is:
1. vitamin C and polymer colloid material are mixed in Hi-mixer, make vitamin C adhere to the polymer colloid material;
2. the polymer colloid material is dissolved in and makes colloid solution in the solvent;
3. colloid solution is added dropwise in the Hi-mixer, the vitamin C that sticks on the polymer colloid material is carried out enclose, granulate subsequently, oven dry.
5. the production method of stable delayed vitamin C preparation according to claim 4; it is characterized in that in Hi-mixer, adding solvent and the vitamin C mix homogeneously that sticks on the polymer colloid material; the reuse comminutor is granulated; oven dry; be sprayed on the microgranule of making drying then while spraying with colloid solution.
6. according to the production method of claim 4,5 described stable delayed vitamin C preparations, it is characterized in that described solvent is ethanol, water, or other organic solvent.
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| Application Number | Priority Date | Filing Date | Title |
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| CN99113722A CN1125638C (en) | 1999-05-20 | 1999-05-20 | Stable delayed vitamin C preparation and its production process |
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| CN99113722A CN1125638C (en) | 1999-05-20 | 1999-05-20 | Stable delayed vitamin C preparation and its production process |
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| CN1274580A CN1274580A (en) | 2000-11-29 |
| CN1125638C true CN1125638C (en) | 2003-10-29 |
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| CN99113722A Expired - Fee Related CN1125638C (en) | 1999-05-20 | 1999-05-20 | Stable delayed vitamin C preparation and its production process |
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Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100446764C (en) * | 2003-03-28 | 2008-12-31 | 上海爱的发制药有限公司 | Vitamic C controlled release pill and its preparation method and use |
| CN1327838C (en) * | 2004-07-08 | 2007-07-25 | 北京科信必成医药科技发展有限公司 | Vitamin C oral disintegration tablet and its preparing method |
| FR2918990B1 (en) * | 2007-07-20 | 2012-12-21 | Innov Ia | PROCESS FOR THE PREPARATION OF STABLE PULVERULENT COMPOSITIONS |
| CN101352187A (en) * | 2007-07-24 | 2009-01-28 | 成都思摩纳米技术有限公司 | Preparation of material capable of slowly releasing vitamin C |
| CN102908319B (en) * | 2012-11-09 | 2014-08-13 | 东北制药集团沈阳第一制药有限公司 | Vitamin C sustained-release pellets and method for preparing same |
| CN103478732B (en) * | 2013-09-30 | 2015-08-19 | 杭州拜善晟生物科技有限公司 | A kind of matrix sustained-release vitamin functional food and preparation method thereof |
| CN105836870B (en) * | 2016-05-25 | 2019-05-03 | 厦门百霖净水科技有限公司 | A kind of household water process delayed vitamin C filtrate and preparation method thereof |
| WO2018141791A1 (en) * | 2017-02-03 | 2018-08-09 | Dsm Ip Assets B.V. | Improved process |
| CN110973369A (en) * | 2019-12-13 | 2020-04-10 | 湖南普菲克生物科技有限公司 | Slow-release sodium butyrate suitable for aquatic animals and preparation method thereof |
| CN113995750B (en) * | 2021-10-19 | 2023-06-23 | 苏州大学 | Pharmaceutical composition for tumor immunotherapy based on vitamin C hydrogel |
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1999
- 1999-05-20 CN CN99113722A patent/CN1125638C/en not_active Expired - Fee Related
Non-Patent Citations (3)
| Title |
|---|
| 华西药学杂志12(3) 1997-12-01 杨红军《羟丙基纤维素对水溶性药物释放的影响》 * |
| 华西药学杂志12(3) 1997-12-01 杨红军《羟丙基纤维素对水溶性药物释放的影响》;解放军药学学报15(3) 1999-06-01 王振国《维生素C缓释包衣片的研究》 * |
| 解放军药学学报15(3) 1999-06-01 王振国《维生素C缓释包衣片的研究》 * |
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