CN112370379A - Plant essential oil spray for repelling mosquitoes, relieving itching and inhibiting bacteria and application - Google Patents
Plant essential oil spray for repelling mosquitoes, relieving itching and inhibiting bacteria and application Download PDFInfo
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/046—Aerosols; Foams
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/02—Local antiseptics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- A—HUMAN NECESSITIES
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- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/02—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings containing insect repellants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/005—Preparations for sensitive skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
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- Oncology (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Rheumatology (AREA)
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Abstract
The invention relates to a plant essential oil spray for repelling mosquitoes, relieving itching and inhibiting bacteria and an application thereof, wherein the plant essential oil spray for repelling mosquitoes, relieving itching and inhibiting bacteria comprises the following raw material components: 96-98 parts of water, 1.5-3 parts of solubilizer and 0.58-1.25 parts of composite plant bacteriostatic essential oil; the composite plant bacteriostatic essential oil comprises lemongrass leaf oil, lavender oil, geranium and sunflower oil and lemon eucalyptus oil. The invention has the beneficial effects that: the plant essential oil spray capable of repelling mosquitoes, relieving itching and inhibiting bacteria is added with the compound plant antibacterial essential oil component compounded by 4 natural plant essential oils, integrates various effects of repelling mosquitoes, relieving itching, resisting inflammation, repairing, inhibiting bacteria and the like, is fresh and soft in smell, does not stimulate respiratory tract, does not have skin irritation, and can be used by infants, pregnant women and lying-in women.
Description
Technical Field
The invention belongs to the technical field of daily chemicals, and particularly relates to a plant essential oil spray for repelling mosquitoes, relieving itching and inhibiting bacteria and application thereof.
Background
The mosquito-repellent spray on the market at present is divided into a chemical type and a plant additive type. The chemical mosquito-repellent spray mainly contains chemically synthesized mosquito-repellent active ingredients such as pyrethroid (Pyrethroids), DEET (DEET), mosquito repellent ester (Immunosin), and picardidin (Picardidin), has micro toxicity, has a certain mosquito-repellent effect, but does not have the effects of relieving itching, inhibiting bacteria and diminishing inflammation, and has no effect on skin itch and resisting bacteria and diminishing inflammation after being bitten by mosquitoes. The plant additive type mosquito repelling spray mainly contains plant extracts, has the problem of poor mosquito repelling effect, and has no antibacterial and disinfection effects. In addition, the two mosquito-repellent sprays are often added with artificial components such as alcohol and essence, and have pungent smell and certain sensitization risk.
Disclosure of Invention
The invention aims to provide the plant essential oil spray for repelling mosquitoes, relieving itching and inhibiting bacteria, which is a pure natural plant component, has no sensitization and inflammation risk, is suitable for all people including infants and pregnant women, has extremely high skin use safety, can obviously improve skin itch caused by mosquito bites while repelling mosquitoes effectively, is inhibited from bacteria and inflammation, and can effectively prevent wound infection.
In order to achieve the purpose, the invention adopts the following technical scheme:
a plant essential oil spray for repelling mosquitoes, relieving itching and inhibiting bacteria comprises the following raw material components:
96-98 parts of water, 1.5-3 parts of solubilizer and 0.58-1.25 parts of composite plant bacteriostatic essential oil; the composite plant bacteriostatic essential oil comprises lemongrass leaf oil, lavender oil, geranium and sunflower oil and lemon eucalyptus oil.
Lemon citronella leaf oil: cymbopogon citratus, also called lemon grass, is a traditional anthelmintic plant in southeast Asia. The lemon citronella leaf oil contains 70-86% of citral, has strong lemon fragrance, and has effects of expelling parasite, deodorizing, and relieving dryness heat.
Lavender oil: lavender is a traditional aromatic plant in Europe, has strong flower fragrance and green grass fragrance, and has the functions of expelling parasites, deodorizing, relieving itching, tranquilizing, diminishing inflammation, sterilizing, repairing wounds and the like. The essential oil contains 40-50% of agilawood acetate, can quickly relieve red swelling and pruritus caused by mosquito bite, and can prevent wound infection and scar.
Geranium sunflower oil: the pelargonium roseum is a household plant which is generally planted around the world, has a delicate smell similar to the fragrance of a rose, and is pleasant and relaxed. The geranium essential oil contains 50-65% of citronellol and geraniol, and has effects of promoting skin repair, preventing wound infection, and effectively resisting bacteria, virus and fungus, and also contains citral, and has mosquito and insect repelling effect.
Lemon eucalyptus oil: the eucalyptus citriodora is a famous mosquito-repellent plant originally produced in Australia, and the essential oil of the eucalyptus citriodora is the only natural mosquito-repellent component recommended by the American centers for disease control. The essential oil contains citronellal 60-90%, and strong odor is a danger signal for mosquito and animal, and is not dare to approach. Meanwhile, the eucalyptus citriodora oil is also a powerful antiviral and antibacterial essential oil, and can help the human body to enhance the immunity and resist infection.
The traditional method of repelling mosquitoes using plants is available in all parts of the world, such as folium artemisiae argyi, geranium, lavender and the like. However, the number of natural plants planted in homes is limited, and the odor of the plants cannot achieve the effect of repelling mosquitoes. The plant essential oil is a high-concentration aromatic substance extracted and purified from the mosquito-repellent plants, retains the natural molecular structure of the plants, is safe and nontoxic, and is harmless to human bodies and the environment. The single plant essential oil has a very limited mosquito repellent effect, and the fragrance is single ー, so that the crowd acceptance is low, the inventor researches show that the four essential oil components are compounded for use, so that natural bacteriostatic active ingredients in the essential oil components interact with each other, the effects are complementary and mutually gained, and further the mosquito repellent and bacteriostatic effects are remarkably improved.
Preferably, the compound plant essential oil consists of lemongrass leaf oil, lavender oil, geranium and sunflower oil and lemon eucalyptus oil according to the mass ratio of 0.03-0.1:0.1-0.3:0.05-0.25: 0.2-0.8.
Preferably, the compound plant essential oil consists of lemongrass leaf oil, lavender oil, geranium and sunflower oil and lemon eucalyptus oil according to the mass ratio of 0.062:0.244:0.174: 0.506.
Preferably, the solubilizer is a lower alcohol.
Preferably, the lower alcohol is one or a combination of several of C3-C6 alcohols.
Preferably, the lower alcohol is butanediol.
Preferably, the plant essential oil spray is prepared by the following method: (1) uniformly mixing a solubilizer and the composite plant bacteriostatic essential oil to obtain a phase A; (2) heating water and cooling to obtain phase B; (3) adding phase A into phase B, and stirring to dissolve uniformly.
Preferably, the heating is carried out to above 80 ℃ and then the temperature is reduced to 40-45 ℃.
Preferably, the stirring speed is 20-30 r/min.
The invention also provides application of the plant essential oil spray with the functions of repelling mosquitoes, relieving itching and inhibiting bacteria in personal care products suitable for infants, pregnant women and lying-in women during home and travel.
The invention has the beneficial effects that:
the plant essential oil spray capable of repelling mosquitoes, relieving itching and inhibiting bacteria is added with the compound plant antibacterial essential oil component compounded by 4 natural plant essential oils, integrates various effects of repelling mosquitoes, relieving itching, resisting inflammation, repairing, inhibiting bacteria and the like, is fresh and soft in smell, does not stimulate respiratory tract, does not have skin irritation, and can be used by infants, pregnant women and lying-in women.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the technical solutions of the present invention will be described in detail below. It is to be understood that the described embodiments are merely a few embodiments of the invention, and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the examples given herein without any inventive step, are within the scope of the present invention. In the following examples, 1 part by weight represents 1 g.
Example 1
The embodiment provides a mosquito-repelling, itching-relieving and bacteriostatic plant essential oil spray, which comprises the following raw material components: 98 parts of water, 1.5 parts of butanediol, 0.03 part of lemongrass leaf oil, 0.3 part of lavender oil, 0.05 part of geranium sunflower oil and 0.2 part of eucalyptus citriodora oil.
The preparation method comprises the following steps: (1) uniformly mixing butanediol, lemongrass leaf oil, lavender oil, geranium sunflower oil and lemon eucalyptus oil to obtain phase A; (2) heating water to 80 ℃, and then cooling to 45 ℃ to obtain a phase B; (3) adding phase A into phase B, stirring at 20r/min to dissolve uniformly.
Example 2
The embodiment provides a mosquito-repelling, itching-relieving and bacteriostatic plant essential oil spray, which comprises the following raw material components: 96 parts of water, 3 parts of butanediol, 0.1 part of lemongrass leaf oil, 0.1 part of lavender oil, 0.25 part of geranium sunflower oil and 0.8 part of eucalyptus citriodora oil.
The preparation method comprises the following steps: (1) uniformly mixing butanediol, lemongrass leaf oil, lavender oil, geranium sunflower oil and lemon eucalyptus oil to obtain phase A; (2) heating water to 85 ℃, and then cooling to 40 ℃ to obtain a phase B; (3) adding phase A into phase B, stirring at 30r/min to dissolve uniformly.
Example 3
The embodiment provides a mosquito-repelling, itching-relieving and bacteriostatic plant essential oil spray, which comprises the following raw material components: 97.014 parts of water, 2 parts of butanediol, 0.062 part of lemongrass leaf oil, 0.244 part of lavender oil, 0.174 part of geranium sunflower oil and 0.506 part of eucalyptus citriodora oil.
The preparation method comprises the following steps: (1) uniformly mixing butanediol, lemongrass leaf oil, lavender oil, geranium sunflower oil and lemon eucalyptus oil to obtain phase A; (2) heating water to 80 ℃, and then cooling to 40 ℃ to obtain a phase B; (3) adding phase A into phase B, stirring at 20r/min to dissolve uniformly.
Comparative example 1
The comparative example provides a plant essential oil spray for repelling mosquitoes, relieving itching and inhibiting bacteria, which comprises the following raw material components: 97.014 parts of water, 2 parts of butanediol, 0.306 part of lemongrass leaf oil, 0.174 part of geranium sunflower oil and 0.506 part of eucalyptus citriodora oil.
Comparative example 2
The comparative example provides a plant essential oil spray for repelling mosquitoes, relieving itching and inhibiting bacteria, which comprises the following raw material components: 97.014 parts of water, 2 parts of butanediol, 0.062 part of lemongrass leaf oil, 0.244 part of lavender oil, 0.174 part of geranium sunflower oil and 0.506 part of mint oil.
Quality standard detection
TABLE 1 quality Standard test results (inventive example 3 sample)
Secondly, detecting the bacteriostatic effect
TABLE 2 results of examination of bacteriostatic effect (sample 3 of example of the present invention)
Third, mosquito repelling effect test
Mosquito repellent effect tests were carried out according to the test standards of GB/T13917.9-2009 insecticide indoor efficacy test and evaluation part 9 of the repellent, and the results are shown in Table 3.
TABLE 3 results of repellent effect test
| Test sample | Effective repelling time/h |
| Example 3 sample | 5.32 |
| Comparative example 1 sample | 3.06 |
| Comparative example 2 sample | 2.88 |
Fourth, test of antipruritic effect
30 guinea pigs weighing between 280 and 310g were selected and randomly divided into 3 groups of blank control group, example 3 group and comparative example 1 group, each group had 10 animals, the right and back paw of each group was unhaired by 1cm × 1cm, and the corresponding samples of each group were applied to the animals, and the blank control group was applied with the same amount of distilled water. After 10 minutes, 50. mu.l/paw of histamine phosphate 0.01% was dropped to the above-mentioned site, and then the above-mentioned site was further added dropwise every 3 minutes, and the concentration of every drop was gradually increased in the order of 0.02%, 0.03% and 0.04% until the foot licking occurred, and the total amount of histamine phosphate added dropwise was recorded as scratchiness threshold, and the results are shown in Table 4.
TABLE 4 antipruritic effect test results
| Group of | Threshold of itch/μ g |
| Blank control group | 36.5±15.22 |
| Practice ofExample 3 group | 55.7±30.23** |
| Comparative example 1 group | 45.2±26.37* |
| Comparative example 2 group | 40.1±27.06 |
Compared with the blank control group, the ratio of the active ingredients,**p<0.01，*p<0.05。
the result shows that the group 3 of the invention has higher itch-causing threshold which is obviously superior to the blank control group and the comparative group, and the invention has better itch-relieving effect.
Fifth, skin irritation test
1. Laboratory animal
1.1 lines and grades: new Zealand rabbits, normal grade.
1.2 quantity and sex: 4, 2 males and 2 females.
1.3 weight: 2.66-2.73 kg.
1.4 units are provided: provided by a Dongxin Hua experiment animal farm in the Huadu district of Guangzhou city (animal production license number SCXK (Guangdong) 2019-.
1.5, feeding management: new Zealand rabbits are bred in a common animal room (the experimental animals use license number: SYXK (Yue) 2016-. The animal room conditions are kept stable all the time to ensure the reliability of the test results. The granulated feed is provided by cooperative medical bioengineering, llc of Jiangsu province (quality certification number: 20200104).
2. Experimental samples example 3 of the present invention.
3. Dose design and grouping
3.1 design method according to technical Specification for safety of cosmetics 2015 edition of skin irritation/corrosivity test
3.2 dose design and grouping: according to the skin irritation/corrosivity test method of the technical Specification for cosmetic safety 2015 edition, the general-grade New Zealand rabbits qualified for quarantine are directly used for multiple skin irritation tests.
4. Experimental methods
4.1 contamination method: 4 common-grade New Zealand rabbits, each half of the female rabbit and the male rabbit. Before the test, the hair on both sides of the spine of the back of the experimental animal is cut off, and the hair removing range is about 3cm multiplied by 3cm respectively on the left side and the right side. About 0.5mL of the test substance was applied to the left skin of the animal over a 2.5cm by 2.5cm area for 1 time per day for 14 days, and the other side was used as a blank control. Shearing hair before each smearing from the next day, removing residual test substance with purified water, treating control area similarly, and observing the result after one hour.
4.2 Observation: the skin reactions were observed under natural light and skin erythema and edema were scored according to the scoring criteria given in table 1 for 14 consecutive days.
5. Determination of results
The average integral per animal per day was calculated according to the following formula, and the skin irritation intensity was determined as shown in Table 6. Average score per animal per day ═ Σ integration of erythema and edema/number of animals tested)/14.
TABLE 5 skin irritation response score
TABLE 6 skin irritation Strength grading
6. Results of the experiment
No skin irritation reactions with edema were observed in the skin of the new zealand rabbits during the observation period, and the mean value of the daily score for each animal was 0 in the sample group. According to the judgment of skin irritation/corrosivity test standard in technical Specification for cosmetic safety (2015 edition), the result shows that the skin irritation strength of the invention is nonirritant for many times. The results are shown in Table 7.
TABLE 7 results of multiple skin irritation tests of the invention on New Zealand rabbits
The above description is only for the specific embodiments of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art can easily conceive of the changes or substitutions within the technical scope of the present invention, and all the changes or substitutions should be covered within the scope of the present invention. Therefore, the protection scope of the present invention shall be subject to the protection scope of the appended claims.
Claims (10)
1. The plant essential oil spray for repelling mosquitoes, relieving itching and inhibiting bacteria is characterized by comprising the following raw material components:
96-98 parts of water, 1.5-3 parts of solubilizer and 0.58-1.25 parts of composite plant bacteriostatic essential oil; the composite plant bacteriostatic essential oil comprises lemongrass leaf oil, lavender oil, geranium and sunflower oil and lemon eucalyptus oil.
2. The plant essential oil spray capable of repelling mosquitoes, relieving itching and inhibiting bacteria according to claim 1 is characterized in that the compound plant essential oil consists of lemongrass leaf oil, lavender oil, geranium and sunflower oil and lemon eucalyptus oil according to a mass ratio of 0.03-0.1:0.1-0.3:0.05-0.25: 0.2-0.8.
3. The plant essential oil spray capable of repelling mosquitoes, relieving itching and inhibiting bacteria according to claim 2 is characterized in that the compound plant essential oil consists of lemongrass leaf oil, lavender oil, geranium and sunflower oil and lemon eucalyptus oil according to a mass ratio of 0.062:0.244:0.174: 0.506.
4. A mosquito-repellent, itching-relieving and bacteriostatic plant essential oil spray according to any one of claims 1 to 3, wherein the solubilizer is a lower alcohol.
5. The mosquito-repelling, itching-relieving and bacteriostatic plant essential oil spray according to claim 4, wherein the lower alcohol is one or a combination of more of C3-C6 alcohols.
6. The mosquito-repelling, itching-relieving and bacteriostatic plant essential oil spray according to claim 5, wherein the lower alcohol is butanediol.
7. The plant essential oil spray for repelling mosquitoes, relieving itching and inhibiting bacteria according to claim 1 is prepared by the following method: (1) uniformly mixing a solubilizer and the composite plant bacteriostatic essential oil to obtain a phase A; (2) heating water and cooling to obtain phase B; (3) adding phase A into phase B, and stirring to dissolve uniformly.
8. The plant essential oil spray for repelling mosquitoes, relieving itching and inhibiting bacteria according to claim 7, which is characterized in that the heating is carried out to be more than 80 ℃, and then the temperature is reduced to 40-45 ℃.
9. The plant essential oil spray for repelling mosquitoes, relieving itching and inhibiting bacteria according to claim 7, wherein the stirring speed is 20-30 r/min.
10. The use of the mosquito-repelling, itching-relieving and bacteria-inhibiting plant essential oil spray of any one of claims 1-9 in a home-based and travel-based personal care product for infants, pregnant women and puerperal women.
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Cited By (4)
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| CN112957283A (en) * | 2021-03-02 | 2021-06-15 | 张容真 | Itching-relieving and anti-allergy plant essential oil spray and preparation method thereof |
| CN113648249A (en) * | 2021-08-10 | 2021-11-16 | 福建香缘生物科技发展有限公司 | Pure natural plant bacteriostatic agent |
| CN115054625A (en) * | 2022-05-23 | 2022-09-16 | 齐齐哈尔大学 | Itching relieving repair lotion and preparation method and application thereof |
| CN115300419A (en) * | 2022-08-10 | 2022-11-08 | 北京思邈香草生物科技有限公司 | Composite vegetable oil with mosquito-repelling, itching-relieving, bacterium-inhibiting and swelling-diminishing effects and preparation method and application thereof |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112957283A (en) * | 2021-03-02 | 2021-06-15 | 张容真 | Itching-relieving and anti-allergy plant essential oil spray and preparation method thereof |
| CN113648249A (en) * | 2021-08-10 | 2021-11-16 | 福建香缘生物科技发展有限公司 | Pure natural plant bacteriostatic agent |
| CN115054625A (en) * | 2022-05-23 | 2022-09-16 | 齐齐哈尔大学 | Itching relieving repair lotion and preparation method and application thereof |
| CN115054625B (en) * | 2022-05-23 | 2023-11-21 | 齐齐哈尔大学 | Itching relieving repair lotion and preparation method and application thereof |
| CN115300419A (en) * | 2022-08-10 | 2022-11-08 | 北京思邈香草生物科技有限公司 | Composite vegetable oil with mosquito-repelling, itching-relieving, bacterium-inhibiting and swelling-diminishing effects and preparation method and application thereof |
| CN115300419B (en) * | 2022-08-10 | 2023-05-26 | 北京思邈香草生物科技有限公司 | Compound vegetable oil with effects of repelling mosquitoes, relieving itching, inhibiting bacteria and relieving swelling, and preparation method and application thereof |
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