CN112379032B - Automatic sample injector, liquid chromatograph and sample injection method of liquid chromatograph - Google Patents
Automatic sample injector, liquid chromatograph and sample injection method of liquid chromatograph Download PDFInfo
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- CN112379032B CN112379032B CN202011161143.2A CN202011161143A CN112379032B CN 112379032 B CN112379032 B CN 112379032B CN 202011161143 A CN202011161143 A CN 202011161143A CN 112379032 B CN112379032 B CN 112379032B
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/04—Preparation or injection of sample to be analysed
- G01N30/24—Automatic injection systems
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/04—Preparation or injection of sample to be analysed
- G01N30/16—Injection
- G01N30/20—Injection using a sampling valve
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/04—Preparation or injection of sample to be analysed
- G01N30/16—Injection
- G01N30/20—Injection using a sampling valve
- G01N2030/201—Injection using a sampling valve multiport valves, i.e. having more than two ports
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Abstract
The invention discloses an automatic sample injector, a liquid chromatograph and a sample injection method of the liquid chromatograph, wherein the automatic sample injector comprises a sample injection platform, a control unit, a driving unit, a sample injection unit, a sample storage unit and a moving unit are arranged on the sample injection platform, the sample storage unit is connected with the driving unit, and the driving unit injects a sample arranged in the sample storage unit into the sample injection unit under the control of the control unit; the liquid chromatograph includes an autosampler through which the liquid chromatograph is injected. The automatic sample injector can further improve the precision, and correspondingly, the liquid chromatograph and the sample injection method of the liquid chromatograph can also improve the sample injection precision.
Description
Technical Field
The invention relates to a sample introduction technology, in particular to an automatic sample injector, a liquid chromatograph and a sample introduction method of the liquid chromatograph.
Background
In chromatographic assays, devices capable of quantitatively introducing a sample into a chromatographic column are called sample injectors. The sample injector is divided into an artificial manual sample injector and an automatic sample injector, the automatic sample injector is an intelligent and automatic sample injector, and the automatic sample injection process can be completed only by setting sample injection parameters and placing a sample to be detected. With the development of the chromatography industry, the automatic sample feeding mode is more and more common, and the use frequency of the automatic sample feeder is improved. Along with the successive release of various manufacturers, the competition of the automatic sample injector is more and more intense, the performance of the sample injector is gradually improved, and the sample injection precision, the sample injection repeatability, the cross contamination and the like are obviously improved.
The existing automatic sample injector is mainly divided into suction type sample injection and push type sample injection. The suction type sample injection mode is that a sample is sucked into the quantitative ring, and then the sample injection is completed by switching the quantitative ring; the push-in type sample introduction method is that a sample is sucked at the tip part of a needle, then the sample is pushed into a chromatographic column by the pushing force of a pump by pricking the needle into a butt joint. If the automatic sample injector is distinguished from the power, the automatic sample injector can be roughly divided into an injection pump and a metering pump, wherein the injection pump is a screw rod which rotates to drive an injector to pull and provide a power source for the sample injector; the metering pump is used for applying liquid phase pump technology to the sample injector so as to provide a power source for the sample injector. The two methods are basically not different, and the sample suction action is completed by drawing the liquid to provide power for the sample feeder.
However, in any of the above methods, the sample feeding is affected by the tension of the sample fluid itself, and this is because no matter the injection pump or the metering pump is used, the pump generates a backflow force when the pump is closed, so that the fluid surface of the sample contracts back along with the tension, thereby causing the backflow of the sample.
Disclosure of Invention
In order to solve the above-mentioned drawbacks of the prior art, an object of the present invention is to provide an autosampler, a liquid chromatograph, and a sample injection method for a liquid chromatograph, wherein the autosampler can further improve the accuracy, and accordingly, the liquid chromatograph and the sample injection method for the liquid chromatograph can also improve the sample injection accuracy.
The technical scheme adopted by the invention for solving the technical problems is as follows: an automatic sample injector comprises a sample injection platform, wherein a control unit, a driving unit, a sample injection unit, a sample storage unit and a moving unit are mounted on the sample injection platform, the sample storage unit is connected with the driving unit, and the driving unit injects a sample arranged in the sample storage unit into the sample injection unit under the control of the control unit;
the driving unit comprises a base body, a pressure cabin is arranged in the base body, one end of the pressure cabin is provided with a sample outlet, the other end of the pressure cabin is provided with a sample inlet, and the sample inlet of the pressure cabin is connected with the sample storage unit through a hose; a vibrating reed is arranged on one side of the pressure cabin, a piezoelectric ceramic piece is connected to the outside of the vibrating reed, and the piezoelectric ceramic piece is driven by a driving circuit;
the driving circuit is connected with the control unit.
Optionally, the sample storage unit includes a plurality of sample storage mechanisms therein, the plurality of sample storage mechanisms are respectively connected with the sample inlet of the pressure chamber, and the connecting pipelines of the plurality of sample storage mechanisms and the pressure chamber are respectively provided with an electromagnetic switching valve;
the electromagnetic switching valve is connected with the control unit.
Optionally, a cleaning solution storage mechanism is further arranged in the sample storage unit, the cleaning solution storage mechanism is connected with the pressure chamber, and an electromagnetic switching valve is arranged on a connecting pipeline between the cleaning solution storage mechanism and the pressure chamber.
Optionally, the sample introduction unit includes a multi-way valve, a sample introduction needle and a needle seat, and the sample introduction needle and the needle seat are respectively connected with the multi-way valve.
By adopting the technical scheme, the vibrating plate vibrates through the piezoelectric ceramic plate, so that a sample is forced to be instantly extruded out in the pressure chamber, and liquid drops are formed at the outlet end and fly out. Compared with the prior art, the automatic sample injector can further improve the sample injection accuracy and ensure the detection accuracy.
The invention further provides a liquid chromatograph based on the automatic sampler, and the liquid chromatograph comprises the automatic sampler.
The liquid chromatograph according to the present invention can further improve the sample injection accuracy by using the above-described auto-injector, and can further improve the detection accuracy as compared with a sample injected by a conventional auto-injector.
The invention also provides a sample injection method of the liquid chromatograph on the basis of the liquid chromatograph, wherein the liquid chromatograph is injected by the automatic sample injector during sample injection, and the sample injection steps of the automatic sample injector are as follows:
the control unit controls the mobile unit to work, so that the driving unit is in butt joint with the sample injection unit;
the control unit controls the drive circuit to start, so that the drive unit injects a sample into the sample injection unit;
after the injection of the sample is finished, the control unit controls the mobile unit to work, so that the driving unit is far away from the sample injection unit;
after the driving unit is far away from the sample injection unit, injecting a sample into a chromatographic column of the liquid chromatograph by the sample injection unit;
when the driving unit injects a sample into the sample injection unit, the piezoelectric ceramic piece is electrified to deform, so that the vibrating piece is bent laterally to press the pressure chamber, and the sample in the pressure chamber is extruded from the sample outlet.
Optionally, the sample storage unit includes a plurality of sample storage mechanisms and a cleaning solution storage mechanism, the plurality of sample storage mechanisms and the cleaning solution storage mechanism are respectively connected to the sample inlet of the pressure chamber, and the connection pipelines of the plurality of sample storage mechanisms and the cleaning solution storage mechanism and the pressure chamber are respectively provided with an electromagnetic switching valve; the electromagnetic switching valve is connected with the control unit;
when the sample introduction is switched, the control unit controls the electromagnetic switching valve on the cleaning solution storage mechanism to be opened, and the other electromagnetic switching valves are closed; the control unit controls the driving unit to act, so that the cleaning liquid enters the sample injection flow path and cleans the sample injection flow path; after the sample injection flow path is cleaned, the control unit controls the electromagnetic switching valve on the cleaning solution storage mechanism to be closed, and simultaneously controls the electromagnetic switching valve on the corresponding sample storage mechanism to be opened.
Optionally, the sample injection unit comprises a multi-way valve, a sample injection needle and a needle seat, and the sample injection needle seat are respectively connected with the multi-way valve;
when the sample is fed, the sample feeding needle is far away from the needle seat through the driving of the moving unit, and meanwhile, the driving unit is in butt joint with the needle seat under the driving of the moving unit; after the drive unit finishes injecting the sample, the drive unit is kept away from the needle seat under the drive of the mobile unit, and meanwhile, the sample injection needle is butted with the needle seat under the drive of the mobile unit.
By adopting the technical scheme, the sample introduction method of the liquid chromatograph can improve the sample introduction precision of the liquid chromatograph and improve the detection precision of the liquid chromatograph.
Drawings
FIG. 1 is a schematic diagram of the system architecture of the autosampler of the present invention;
fig. 2 is a schematic structural view of the driving unit of the present invention.
Detailed Description
The present application will be described in further detail with reference to the following drawings and examples. It is to be understood that the specific embodiments described herein are merely illustrative of the relevant invention and not restrictive of the invention. It should be noted that, for convenience of description, only the portions related to the present invention are shown in the drawings.
It should be noted that the embodiments and features of the embodiments in the present application may be combined with each other without conflict. The present application will be described in detail below with reference to the embodiments with reference to the attached drawings.
As shown in fig. 1, an automatic sampler comprises a sample introduction platform, a control unit 100, a driving unit 200, a sample introduction unit 300, a sample storage unit 400 and a moving unit are installed on the sample introduction platform, the sample storage unit 400 is connected with the driving unit 200, and the driving unit 200 injects a sample in the sample storage unit 400 into the sample introduction unit 300 under the control of the control unit 100. In the invention, the sample introduction platform can adopt the existing sample introduction platform which is a three-axis sample introduction platform with the movement in the xyz three directions, so that a three-axis moving system on the sample introduction platform is a moving unit.
In the present invention, as shown in fig. 2, the driving unit 200 includes a base 210, a pressure chamber 220 is disposed in the base 210, one end of the pressure chamber 220 is provided with a sample outlet 230, the other end is provided with a sample inlet 240, and the sample inlet 240 of the pressure chamber 220 is connected to the sample storage unit 400 through a hose. A vibrating plate 250 is arranged on one side of the pressure chamber 220, a piezoelectric ceramic plate 260 is connected to the outside of the vibrating plate 250, the piezoelectric ceramic plate 260 is driven by a driving circuit 270, and the driving circuit 270 is connected with the control unit 100.
In the sample injection process, the control unit 100 controls the driving circuit 270, so that the driving circuit 270 applies a voltage to the piezoelectric ceramic plate 260, the piezoelectric ceramic plate 260 deforms after being powered, because the vibrating plate 250 is connected with the piezoelectric ceramic plate 260, the deformation part of the piezoelectric ceramic plate 260 presses the side part of the vibrating plate 250, the pressure in the pressure chamber 220 increases suddenly, the sample is pressed in the pressure chamber 220, the sample is rapidly extruded out of the pressure chamber 220 from the sample outlet 230, and the sample extruded from the pressure chamber 220 is injected into the sample injection unit 300, thereby completing the sample injection action.
In the present invention, the base 210 is further provided with a baffle 280 at the position of the sample outlet 230, the center of the baffle 280 is provided with a central hole 290, and the aperture of the central hole 290 is smaller than the aperture of the sample outlet 230. After the sample liquid drops are sprayed out from the sample outlet 230, the piezoelectric ceramic piece 260 loses power and recovers, and meanwhile, the vibrating piece 250 also begins to reset, so that the pressure chamber 220 supplements the sample from the sample inlet 240, and the sample outlet 230 can cut the sample liquid drops due to the existence of the baffle 280, so that the sample liquid drops are completely sprayed out, and the sample injection precision of the sample can be further improved.
In the present invention, during the sample feeding process, the sample feeding amount of the sample is directly related to the pressure of the pressure chamber 220, the pressure in the pressure chamber 220 is in direct proportion to the deformation amount of the vibration plate 250, the deformation amount of the vibration plate 250 is in direct proportion to the deformation amount of the piezoelectric ceramic plate 260, and the deformation amount of the piezoelectric ceramic plate 260 is in direct proportion to the voltage applied by the driving circuit 270, so the sample feeding amount is in direct proportion to the voltage of the driving circuit 270 to the piezoelectric ceramic plate 260. In the invention, the control unit 100 controls the driving circuit 270, and the sample injection is performed by matching with the driving unit 200, so that accurate sample injection is completed, and the sample injection precision is improved. In the invention, the control unit 100 adopts a singlechip, and can adopt an STM32F769 PLC control chip.
In the present invention, the sample storage unit 400 includes a plurality of sample storage mechanisms 410, the sample storage mechanisms 410 may be in the form of a kit, different sample liquids are respectively contained in each sample storage mechanism 410, meanwhile, the plurality of sample storage mechanisms 410 are respectively connected to the sample inlet 240 of the pressure chamber 220, and the connecting pipelines of the plurality of sample storage mechanisms 410 and the pressure chamber 220 are respectively provided with an electromagnetic switching valve 430, wherein the electromagnetic switching valve 430 is connected to the control unit 100, and the electromagnetic switching valve 430 is controlled by the control unit 100 to realize switching of different samples.
Of course, in order to prevent the liquid path piping from cross contamination, a cleaning solution storage mechanism 420 is further provided in the sample storage unit 400, the cleaning solution storage mechanism 420 is also connected to the pressure chamber 220, and the connection piping of the cleaning solution storage mechanism 420 and the pressure chamber 220 is also provided with the electromagnetic switching valve 430.
In the present invention, the sample injection unit 300 includes a multi-way valve 310, a sample injection needle 320, and a needle holder 330, and the sample injection needle 320 and the needle holder 330 are respectively connected to the multi-way valve 310.
In the present invention, the needle holder 330 can be fixedly installed at the origin position of the xyz triaxial movement system of the sample platform, the sample needle 320 has movements in the x direction and the z direction on the sample platform, and the driving unit 200 has movements in the y direction.
Based on the autosampler provided by the invention, the invention also provides a liquid chromatograph, and the liquid chromatograph comprises the autosampler.
In addition, in the liquid chromatograph in the initial state, the drive unit 200 and the injection needle 320 are both located at a position away from the needle stand 330 in the auto-injector. When the liquid chromatograph starts to sample, the sample injection steps are as follows:
s1, the control unit 100 controls the driving unit 200 to move towards the direction of the needle seat 330, so that the sample outlet 230 of the driving unit 200 is in butt joint with the needle seat 330 of the sample introduction unit 300;
s2, the control unit 100 controls the driving circuit 270 to start, so that the driving unit 200 injects the sample into the needle seat 330 of the sample injection unit 300;
and S3, after the injection of the sample is completed, the control unit 100 controls the driving unit 200 to move towards the direction far away from the needle seat 330, after the driving unit 200 is far away from the needle seat 330, the control unit 100 controls the injection needle 320 to move towards the direction of the needle seat 330, and enables the injection needle 320 to be in butt joint with the needle seat 330, so that the pressure maintaining of the needle seat 330 is realized, meanwhile, the electromagnetic valve of the multi-way valve 310 is switched, so that a high-pressure area is formed among the injection needle 320, the needle seat 330 and the multi-way valve 310, and the injected sample liquid drops are sent into a chromatographic column of the liquid chromatograph.
In the present invention, the sample storage unit 400 includes a plurality of sample storage mechanisms 410 and a cleaning solution storage mechanism 420, during sample injection, a plurality of different samples need to be switched, and before switching, the liquid path pipeline needs to be cleaned. Therefore, when switching the sample injection, the control unit 100 first controls the electromagnetic switching valve 430 on the cleaning solution storage mechanism 420 to be opened, and the rest of the electromagnetic switching valves 430 to be closed; then, the control unit 100 controls the driving unit 200 to operate, so that the cleaning solution enters the sample injection flow path to clean the sample injection flow path; after the sample injection flow path is cleaned, the control unit 100 controls the electromagnetic switching valve 430 on the cleaning solution storage mechanism 420 to close, and controls the corresponding electromagnetic switching valve 430 on the sample storage mechanism 410 to open, thereby completing the switching of the samples.
The foregoing description is only exemplary of the preferred embodiments of the application and is illustrative of the principles of the technology employed. It will be appreciated by a person skilled in the art that the scope of the invention as referred to in the present application is not limited to the embodiments with a specific combination of the above-mentioned features, but also covers other embodiments with any combination of the above-mentioned features or their equivalents without departing from the inventive concept. For example, the above features may be replaced with (but not limited to) features having similar functions disclosed in the present application.
Other technical features than those described in the specification are known to those skilled in the art, and are not described herein in detail in order to highlight the innovative features of the present invention.
Claims (6)
1. An automatic sample injector is characterized by comprising a sample injection platform, wherein the sample injection platform is provided with a control unit, a driving unit, a sample injection unit, a sample storage unit and a moving unit, the sample storage unit is connected with the driving unit, and the driving unit injects a sample arranged in the sample storage unit into the sample injection unit under the control of the control unit;
the driving unit comprises a base body, a pressure cabin is arranged in the base body, one end of the pressure cabin is provided with a sample outlet, a blocking piece is arranged at the position of the sample outlet, the center of the blocking piece is provided with a central hole, the aperture of the central hole is smaller than the aperture of the sample outlet, the other end of the sample outlet is provided with a sample inlet, and the sample inlet of the pressure cabin is connected with the sample storage unit through a hose; a vibrating reed is arranged on one side of the pressure chamber, a piezoelectric ceramic piece is connected to the outside of the vibrating reed and is driven by a driving circuit, and the driving circuit is connected with the control unit;
the sample introduction unit comprises a multi-way valve, a sample introduction needle and a needle seat, and the sample introduction needle and the needle seat are respectively connected with the multi-way valve;
when sampling, the method comprises the following steps:
the control unit controls the driving unit to move towards the needle seat, so that the sample outlet is in butt joint with the needle seat;
the control unit controls the driving unit to inject the sample into the needle seat;
the control unit controls the driving unit to be far away from the needle seat, and simultaneously controls the sample injection needle to be in butt joint with the needle seat for pressure maintaining;
the control unit controls the multi-way valve to switch flow paths, so that a high-pressure area is formed among the sample injection needle, the needle seat and the multi-way valve, and a sample is injected into a chromatographic column of the liquid chromatograph.
2. The automatic sample injector according to claim 1, wherein the sample storage unit comprises a plurality of sample storage mechanisms therein, the plurality of sample storage mechanisms are respectively connected with the sample inlets of the pressure chambers, and the connecting pipelines of the plurality of sample storage mechanisms and the pressure chambers are respectively provided with electromagnetic switching valves;
the electromagnetic switching valve is connected with the control unit.
3. The autosampler according to claim 2, wherein a cleaning solution storage mechanism is further provided in the sample storage unit, the cleaning solution storage mechanism is connected to the pressure chamber, and a connection pipeline between the cleaning solution storage mechanism and the pressure chamber is provided with an electromagnetic switching valve.
4. A liquid chromatograph comprising the autosampler of any of claims 1-3.
5. A sample introduction method of a liquid chromatograph is characterized in that a liquid chromatograph is subjected to sample introduction through an automatic sample introduction device when the sample introduction is carried out, the automatic sample introduction device comprises a sample introduction platform, a control unit, a driving unit, a sample introduction unit, a sample storage unit and a moving unit are mounted on the sample introduction platform, the sample storage unit is connected with the driving unit, and the driving unit injects a sample arranged in the sample storage unit into the sample introduction unit under the control of the control unit; the driving unit comprises a base body, a pressure cabin is arranged in the base body, one end of the pressure cabin is provided with a sample outlet, a blocking piece is arranged at the position of the sample outlet, the center of the blocking piece is provided with a center hole, the aperture of the center hole is smaller than the aperture of the sample outlet, the other end of the pressure cabin is provided with a sample inlet, and the sample inlet of the pressure cabin is connected with the sample storage unit through a hose; a vibrating reed is arranged on one side of the pressure chamber, a piezoelectric ceramic piece is connected to the outside of the vibrating reed and is driven by a driving circuit, and the driving circuit is connected with the control unit; the sample introduction unit comprises a multi-way valve, a sample introduction needle and a needle seat, and the sample introduction needle and the needle seat are respectively connected with the multi-way valve;
the sample introduction steps of the automatic sample injector are as follows:
the control unit controls the driving unit to move towards the needle seat, so that the sample outlet is in butt joint with the needle seat;
the control unit controls the driving unit to inject the sample into the needle seat;
the control unit controls the driving unit to be far away from the needle seat, and simultaneously controls the sample injection needle to be in butt joint with the needle seat for pressure maintaining;
the control unit controls the multi-way valve to switch flow paths, so that a high-pressure region is formed among the sample injection needle, the needle seat and the multi-way valve, and a sample is injected into a chromatographic column of the liquid chromatograph;
when the driving unit injects a sample into the sample injection unit, the piezoelectric ceramic piece is electrified to generate deformation, so that the vibrating piece is bent laterally to press the pressure chamber, and the sample in the pressure chamber is extruded from the sample outlet.
6. The sample injection method for the liquid chromatograph according to claim 5, wherein the sample storage unit comprises a plurality of sample storage mechanisms and a cleaning solution storage mechanism, the plurality of sample storage mechanisms and the cleaning solution storage mechanism are respectively connected to the sample injection port of the pressure chamber, and the connection pipelines of the plurality of sample storage mechanisms and the cleaning solution storage mechanism and the pressure chamber are respectively provided with an electromagnetic switching valve; the electromagnetic switching valve is connected with the control unit;
when the sample introduction is switched, the control unit controls the electromagnetic switching valve on the cleaning solution storage mechanism to be opened, and the other electromagnetic switching valves are closed; the control unit controls the driving unit to act, so that the cleaning liquid enters the sample injection flow path and cleans the sample injection flow path; after the sample injection flow path is cleaned, the control unit controls the electromagnetic switching valve on the cleaning solution storage mechanism to be closed, and simultaneously controls the electromagnetic switching valve on the corresponding sample storage mechanism to be opened.
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Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS63303751A (en) * | 1987-06-05 | 1988-12-12 | Nec Corp | Ink jet recording device |
| TW200409701A (en) * | 2002-12-03 | 2004-06-16 | Nanodynamics Inc | Pressure chamber of a piezoelectric ink jet print head and fabrication method thereof |
| CN1515411A (en) * | 2003-01-07 | 2004-07-28 | 飞赫科技股份有限公司 | Piezoelectric ink-jet head ink-cavity structure and its manufacture method |
| CN102896061A (en) * | 2012-10-15 | 2013-01-30 | 哈尔滨工业大学 | Piezoelectric micro-jet device based on bending vibration sandwich transducer |
| CN105891391A (en) * | 2016-06-29 | 2016-08-24 | 天津博纳艾杰尔科技有限公司 | Automatic sampling device |
| CN108896690A (en) * | 2018-07-16 | 2018-11-27 | 中国矿业大学 | A kind of the HPLC sampling device and sample injection method of multi pass acquisition |
| CN109100458A (en) * | 2018-10-16 | 2018-12-28 | 安徽皖仪科技股份有限公司 | Chromatography autosampler and automatic sampling method |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH05309841A (en) * | 1992-03-11 | 1993-11-22 | Tokyo Electric Co Ltd | Production of ink jet printer head |
| JP3404205B2 (en) * | 1995-12-11 | 2003-05-06 | 株式会社島津製作所 | Liquid chromatograph / mass spectrometer |
| JPH10305574A (en) * | 1997-05-09 | 1998-11-17 | Kyocera Corp | Ink jet printer head |
| CN1228190C (en) * | 2002-10-16 | 2005-11-23 | 飞赫科技股份有限公司 | Piezo ink-jet head and shaking layer shaping method |
| CN102369434B (en) * | 2009-04-16 | 2014-01-15 | 株式会社岛津制作所 | Liquid chromatograph |
| US8118410B2 (en) * | 2009-08-31 | 2012-02-21 | Hewlett-Packard Development Company, L.P. | Piezoelectric printhead and related methods |
| CN203133096U (en) * | 2013-03-21 | 2013-08-14 | 浙江大学 | Full-automatic liquid sample collecting and feeding system without mixing and dead volume |
| CN107561198A (en) * | 2017-08-24 | 2018-01-09 | 通用（深圳）仪器有限公司 | A kind of liquid chromatograph automatic sampler |
| CN109572218B (en) * | 2019-01-17 | 2024-03-01 | 南京沃航智能科技有限公司 | Piezoelectric composite excitation ink-jet printer nozzle |
-
2020
- 2020-10-26 CN CN202011161143.2A patent/CN112379032B/en active Active
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS63303751A (en) * | 1987-06-05 | 1988-12-12 | Nec Corp | Ink jet recording device |
| TW200409701A (en) * | 2002-12-03 | 2004-06-16 | Nanodynamics Inc | Pressure chamber of a piezoelectric ink jet print head and fabrication method thereof |
| CN1515411A (en) * | 2003-01-07 | 2004-07-28 | 飞赫科技股份有限公司 | Piezoelectric ink-jet head ink-cavity structure and its manufacture method |
| CN102896061A (en) * | 2012-10-15 | 2013-01-30 | 哈尔滨工业大学 | Piezoelectric micro-jet device based on bending vibration sandwich transducer |
| CN105891391A (en) * | 2016-06-29 | 2016-08-24 | 天津博纳艾杰尔科技有限公司 | Automatic sampling device |
| CN108896690A (en) * | 2018-07-16 | 2018-11-27 | 中国矿业大学 | A kind of the HPLC sampling device and sample injection method of multi pass acquisition |
| CN109100458A (en) * | 2018-10-16 | 2018-12-28 | 安徽皖仪科技股份有限公司 | Chromatography autosampler and automatic sampling method |
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