CN112362561A - Image processing system and method - Google Patents
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Abstract
The invention discloses an image processing system and method, relating to the technical field of microscopic observation, wherein the image processing system comprises: the device comprises a U disk device, an image sensor chip, a processing device and an imaging auxiliary system. The technical scheme of the invention has the beneficial effects that: the direct projection microscopic imaging is carried out on the biological cell sample by utilizing the nanoscale pixel size and hundred million pixel scale image sensor chip, and the requirements of high resolution and large field of view are met; meanwhile, the microscope device in the technical scheme has the advantages of simple overall structure, small size, portability and simplicity, can greatly improve the observation efficiency of biological cells, and reduces the technical requirements on observers.
Description
Technical Field
The invention relates to the technical field of microscopic observation, in particular to an image processing system and method.
Background
In the fields of relevant life scientific research and medical science, microscopic observation of biological cells has great demand and significance; in the field of life science research, the cell level of a biological sample is observed, and specific information such as the life cycle, physiological activities, morphological changes and the like of cells can be obtained; the information can help human beings to better study the cell commonality and the individual difference, and the understanding of the whole biological system is deepened; in the field of medical diagnosis, sample observation of patient cells is an auxiliary means for providing a diagnosis result, and for example, in a blood routine examination, a medical worker can visually diagnose the physical condition of a patient by observing the number change and morphological distribution of red blood cells, white blood cells, and platelets in blood.
In the prior art, a microscope is generally adopted to realize microscopic observation, however, the traditional microscope inevitably has the contradiction between high-resolution imaging and large-field observation, and the high-resolution imaging of a large number of samples is usually realized by a scanning mode, but the process is time-consuming and labor-consuming; moreover, the traditional microscope has a large volume, is not easy to move, and has large limitation on the observation position; moreover, microscopic observation equipment is usually expensive, and the operation process is complicated, so that the requirements on observation personnel and observation places in the cell research process are improved, and the development of microscopic observation technology is limited.
Disclosure of Invention
According to the problems in the prior art, an image processing system and an image processing method are provided, which aim to meet the requirements of high resolution and large view field at the same time, reduce the overall volume of a microscopic observation device and greatly improve the portability and simplicity of the microscopic observation device.
The technical scheme specifically comprises the following steps:
an image processing system, comprising:
the USB flash disk device comprises a USB flash disk device, wherein a groove is formed in the upper surface of the USB flash disk device, and a plurality of first contact electrodes are arranged at the bottom of the groove;
the lower surface of the image sensor chip is provided with a plurality of second contact electrodes, when the image sensor chip is fixed in the groove, the first contact electrodes and the second contact electrodes are in one-to-one corresponding contact, the upper surface of the image sensor chip is provided with a microfluidic module, and a sample to be observed is placed in the microfluidic module;
the USB flash disk device is accessed to the processing device through a pluggable data transmission interface;
the U disk device further comprises:
and the signal conversion unit is respectively connected with the first contact electrode and the data transmission interface, and is used for converting the electric signal acquired by the first contact electrode into communication data and sending the communication data to the processing device from the data transmission interface for processing, and converting the communication data acquired by the data transmission interface into an electric signal and sending the electric signal to the image sensor chip through the first contact electrode.
Preferably, when the image sensor chip is fixed in the groove, the transmitting electrode in the first contact electrode is correspondingly contacted with the receiving electrode in the second contact electrode, and the receiving electrode in the first contact electrode is correspondingly contacted with the transmitting electrode in the second contact electrode;
the signal conversion unit includes:
one end of the level conversion circuit is respectively connected with the receiving electrode and the transmitting electrode in the first contact electrode, and the level conversion circuit is used for converting an electric signal and a serial port signal;
the first conversion circuit is connected between one end of the level conversion circuit and the data transmission interface and is used for converting the serial port signal into a digital signal and sending the digital signal to the processing device through the data transmission interface;
and the second conversion circuit is connected between the other end of the level conversion circuit and the data transmission interface and is used for converting the digital signal sent by the processing device into a serial port signal and sending the serial port signal to the level conversion circuit.
Preferably, the image sensor chip includes:
the first control unit is used for controlling the image sensor chip to work;
the processing device comprises:
the second control unit is used for outputting a control signal through the data transmission interface, and the control signal is transmitted to the first control unit of the image sensor chip through the U disk device so as to indicate the first control unit to control the working state of the image sensor chip;
the processing unit is used for receiving and processing the communication data through the data transmission interface;
and the display unit is connected with the processing unit and used for displaying the processing result of the processing unit.
Preferably, when the image sensor chip is fixed in the groove, the power supply electrode in the first contact electrode is correspondingly contacted with the power supply electrode in the second contact electrode, and then the image sensor chip is powered by the U-disk device through the first contact electrode and the second contact electrode.
Preferably, the imaging system further comprises an imaging support system, and the imaging support system specifically comprises:
the light source is fixedly arranged on one side of the U disk device, and a collimating device is arranged on the emergent surface of the light source and is used for collimating emergent rays of the light source into collimated rays parallel to the upper surface of the image sensor chip;
the reflecting mirror is fixedly arranged on the upper surface of the U-disk device and forms a fixed angle with the upper surface, and the reflecting surface of the reflecting mirror faces the upper surface of the image sensor chip arranged in the groove and is used for reflecting the collimated light and forming incident light which vertically enters the upper surface of the image sensor chip.
Preferably, the lower surface of the U-disc device is further provided with a plurality of adjustable feet for adjusting the height of the U-disc device.
Preferably, the microfluidic module has a cover body, a cavity is formed between the cover body and the upper surface of the image sensor chip, and the sample to be observed is loaded in the cavity.
Preferably, the microfluidic device is provided with a liquid inlet and a liquid outlet, and the liquid inlet is communicated with the liquid outlet and the cavity;
the liquid inlet is used for injecting the sample to be observed in a liquid state or cleaning liquid into the cavity;
the liquid outlet is used for extracting the sample to be observed or the cleaning liquid in a liquid state from the interior of the cavity.
Preferably, the liquid inlet is connected with a sampling needle, the liquid outlet is connected with a balloon, and the sample to be observed or the cleaning solution in a liquid state is sucked from the liquid inlet in a manner of pressing the balloon.
In the technical scheme, the method further comprises the following steps:
an image processing method applied to the image processing system is characterized by comprising the following steps:
step S1, an image sensor chip is fixedly arranged in a groove of a U disk device, so that a first contact electrode of the U disk device is correspondingly connected with a second contact electrode of the image sensor chip;
step S2, acquiring image data of a sample to be observed through the image sensor chip, wherein the image data is sent to the U disk device through the second contact electrode and the first contact electrode in an electric signal mode;
step S3, the U disk device converts the electric signal to form communication data suitable for being sent to a processing device, and sends the communication data to the processing device through a pluggable data transmission interface;
step S4, the processing device processes the communication data and displays the processing result.
The technical scheme of the invention has the beneficial effects that: the direct projection microscopic imaging is carried out on the biological cell sample by utilizing the nanoscale pixel size and hundred million pixel scale image sensor chip, and the requirements of high resolution and large field of view are met; meanwhile, the microscope device in the technical scheme has the advantages of simple overall structure, small size, portability and simplicity, can greatly improve the observation efficiency of biological cells, and reduces the technical requirements on observers.
Drawings
Embodiments of the present invention will now be described more fully hereinafter with reference to the accompanying drawings. The drawings are, however, to be regarded as illustrative and explanatory only and not as restrictive of the scope of the invention.
FIG. 1 is a block diagram of an embodiment of an image processing system according to the present invention;
FIG. 2 is a partial implementation structure diagram of a U disk device according to an embodiment of the present invention;
FIG. 3 is a side view of a partial U disk device according to an embodiment of the present invention;
FIG. 4 is a partial implementation structure diagram of a U disk device and an image scanner chip according to an embodiment of the present invention;
FIG. 5 is a block diagram of an embodiment of a lighting device according to the present invention;
FIG. 6 is a block diagram of an image processing system according to an embodiment of the present invention;
FIG. 7 is a structural diagram of a U disk device according to an embodiment of the present invention;
FIG. 8 is a structural diagram of a signal conversion unit according to an embodiment of the present invention;
FIG. 9 is a structural diagram of an image sensor chip according to an embodiment of the present invention;
fig. 10 is a structural configuration diagram of a processing apparatus according to an embodiment of the present invention.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
It should be noted that the embodiments and features of the embodiments may be combined with each other without conflict.
The invention is further described with reference to the following drawings and specific examples, which are not intended to be limiting.
The present invention provides an image processing system, comprising:
the USB flash disk device 1 is characterized in that a groove A1 is formed in the upper surface of the USB flash disk device 1, and a plurality of first contact electrodes are arranged at the bottom of the groove A1;
the lower surface of the image sensor chip 2 is provided with a plurality of second contact electrodes, when the image sensor chip 2 is fixed in the groove A1, the first contact electrodes and the second contact electrodes are in one-to-one corresponding contact, the upper surface of the image sensor chip 2 is provided with a microfluidic module A2, and a sample to be observed is placed in the microfluidic module A3;
the processing device 3, the U disk device 1 accesses the processing device 3 through a pluggable data transmission interface A3;
the usb device 1 further includes:
and a signal conversion unit 11, respectively connected to the first contact electrode and the data transmission interface A3, for converting the electrical signal acquired via the first contact electrode into communication data and transmitting the communication data from the data transmission interface A3 to the processing device 3 for processing, and converting the communication data acquired via the data transmission interface A3 into an electrical signal and transmitting the electrical signal to the image sensor chip 2 through the first contact electrode.
In a preferred embodiment, each pixel in the image sensor chip 2 may be a semi-floating gate transistor as described in the literature (Wang P, Lin X, Liu L, et al. A semi-floating gate transistor for low-voltage ultra-memory and sensing operation [ J ]. Science (New York, N.Y.),2013,341(6146): 640. 643).
Specifically, the size of a single photosensitive pixel unit of the image sensor chip 2 is less than or equal to 200nm × 200nm, and the total number of pixels of the image sensor chip 2 is more than or equal to 1 hundred million. Since the smaller the pixel size, the higher the resolution, microscopic observations of biological samples can be made from the single cell level. Meanwhile, because the pixel scale is very large, a large number of samples can be observed at the same time, and the microscopic observation efficiency is improved.
Specifically, the shape and depth of the groove a1 are determined by the shape and thickness of the image sensor chip 2.
Specifically, the processing device 3 is a computer.
Specifically, the data transmission interface a3 is a USB interface.
Specifically, the size of a single pixel of the image sensor chip 2 is nanometer, and the size of the whole pixel is hundred million, and the image sensor chip 2 is used for optical projection imaging of a sample.
Specifically, the microfluidic module a2 is tightly attached to the upper surface of the image sensor chip 2 for loading a sample and performing optical projection imaging.
Specifically, the microfluidic module a2 may be made of metal.
Specifically, the cover of the microfluidic module a2 is made of a transparent material, and the cover and the surface of the image sensor chip 2 form a cavity for loading a sample, and the shape of the cavity can be rectangular or circular.
In the prior art, there is certain distance between image acquisition chip 2 and the sample, and through the refraction of light, there is certain deformation and error in the image that the image acquisition chip gathered, need just can obtain more accurate sample image through the processing in computer later stage, in this technical scheme, does not have the space between sample and the image sensor chip 2, and image sensor chip 2 can directly gather the sample image, has left out the processing step in computer later stage.
Specifically, when the image sensor chip 2 is fixed in the groove a1, the transmitting electrode in the first contact electrode is in corresponding contact with the receiving electrode in the second contact electrode, and the receiving electrode in the first contact electrode is in corresponding contact with the transmitting electrode in the second contact electrode;
the signal conversion unit 11 includes:
one end of the level conversion circuit 111 is respectively connected with a receiving electrode and a transmitting electrode in the first contact electrode, and the level conversion circuit 111 is used for converting an electric signal and a serial port signal;
the first conversion circuit 112 is connected between one end of the level conversion circuit 111 and the data transmission interface A3, and is used for converting the serial port signal into a digital signal and sending the digital signal to the processing device 3 through the data transmission interface A3;
and a second conversion circuit 113 connected between the other end of the level conversion circuit 111 and the data transmission interface a3, for converting the digital signal sent by the processing device 3 into a serial port signal and sending the serial port signal to the level conversion circuit 111.
Specifically, the level shifter 111 is a common TTL shifter, and functions to convert the electrical signal and the serial signal into each other.
Specifically, the first conversion circuit 112 is a common ADC circuit.
Specifically, the second conversion circuit 113 is a common CDA circuit.
Specifically, the image sensor chip 2 includes:
a first control unit 21 for controlling the image sensor chip 2 to operate;
the processing device 3 includes:
a second control unit 31 for outputting a control signal through the data transmission interface a3, the control signal being transmitted to the first control unit 21 of the image sensor chip 2 via the usb device 1 to instruct the first control unit 21 to control the operating state of the image sensor chip 2;
the processing unit 32 is used for receiving and processing communication data through the data transmission interface A3;
and a display unit 33 connected to the processing unit 32 for displaying the processing result of the processing unit 32.
Specifically, the second control unit 31 is a control button on the computer, and the user controls the image sensor chip 2 to start operating by pressing the control button.
Specifically, the display unit 33 is a display screen in the processing apparatus 3.
Specifically, when the image sensor chip 2 is fixed in the groove a1, the power supply electrode of the first contact electrode is correspondingly contacted with the power supply electrode of the second contact electrode, and the usb device 1 supplies power to the image sensor chip 2 through the first contact electrode and the second contact electrode.
Specifically, the imaging system further includes an imaging support system 4, where the imaging support system 4 specifically includes:
a light source 41 fixedly arranged at one side of the U disk device 1, wherein a collimating device 42 is arranged on the emergent surface of the light source 41 and is used for collimating the emergent light of the light source 41 into collimated light parallel to the upper surface of the image sensor chip 2;
and the reflector 43 is fixedly arranged on the upper surface of the U disk device 1 and forms a fixed angle with the upper surface, and the reflecting surface of the reflector 43 faces the upper surface of the image sensor chip 2 arranged in the groove A1 and is used for reflecting collimated light and forming incident light which is vertically incident to the upper surface of the image sensor chip 2.
Specifically, the fixed angle of the mirror 43 to the upper surface of the U disk device 1 is 45 °.
Specifically, in the prior art, the light source is generally disposed directly above the image sensor chip 2, which makes the occupied space of the whole device larger, and the reflector 43 is used to reduce the height of the whole image processing system, so that the device is lighter and easier to carry.
Specifically, the light source 41 is an LED point light source, the center wavelength of which is located in the visible light region, the wavelength band of which is 400nm to 700nm, and the bandwidth of which is 5nm to 20 nm.
Specifically, the lower surface of the U-disk device 1 is further provided with a plurality of adjustable feet a4 for adjusting the height of the U-disk device 1.
In particular, the adjustable foot pad a4 is also used for supporting the whole structure, and the material can be one of metal, stainless steel and plastic.
Specifically, the microfluidic module a2 has a cover body, the cover body and the upper surface of the image sensor chip 2 form a cavity, and a sample to be observed is loaded in the cavity.
Specifically, the microfluidic device a2 has a liquid inlet a21 and a liquid outlet a22, and the liquid inlet a21 is communicated with the liquid outlet a22 and the cavity;
the liquid inlet A21 is used for injecting a liquid sample to be observed or a cleaning solution into the cavity;
the liquid outlet a22 is used to draw the sample to be observed or the cleaning liquid in a liquid state out of the interior of the chamber.
Specifically, the liquid inlet a21 and the liquid outlet a22 are made of metal materials.
Specifically, the liquid inlet a21 is connected with a sampling needle a5, the liquid outlet a22 is connected to the balloon a6, and a sample to be observed or a cleaning solution in a liquid state is sucked from the liquid inlet a21 by pressing the balloon a 6.
In another preferred embodiment, each pixel in the image sensor chip 2 may be configured as a composite dielectric gate photosensitive detector in US8, 604, 409, and the remaining features are not changed.
Specifically, the image processing system is used for observing a sample, and the method specifically comprises the following steps:
further, the image sensor chip 2 is snapped into the groove a1 of the U-disk device 1, so that the first contact electrode of the U-disk device 1 and the second contact electrode of the image sensor chip 2 are correspondingly connected.
Further, a microfluidic device a2 was fixed on the image sensor chip 2.
Further, the power supply in the imaging assisting system 4 is turned on, the light source 41 emits light, and the collimating device 42 collimates the light into collimated light parallel to the upper surface of the image sensor chip 2.
Further, the mirror 43 reflects the collimated light onto the image sensor chip 2.
Further, a sample was placed at needle a5 and drawn into the cavity by squeezing balloon a 6.
Further, the second control unit 31 outputs a digital signal to the U-disc device 1 through the data transmission interface a3, the digital signal is converted into a serial signal by the second conversion circuit 113, and then converted into an electrical signal by the level conversion circuit 111, and the electrical signal is transmitted from the sending electrode of the first contact point to the receiving electrode of the second contact electrode.
Further, the second contact electrode sends the converted electrical signal to the first control unit 21 in the image sensor chip 2, and the first control unit 21 controls the image sensor chip 2 to start operating.
Further, the image sensor chip 2 performs optical projection imaging on the sample.
Further, the image sensor chip 2 outputs the data of the optical projection imaging to an electrical signal to the usb device 1, the electrical signal is converted to a serial port signal by the level conversion circuit 111, and then converted to a digital signal by the first conversion circuit 112, and the digital signal is transmitted from the data transmission interface a3 to the processing device 3.
Further, the processing unit 32 receives and processes the communication data included in the digital signal, and the display unit 33 displays the processing result of the processing unit 32 to the user.
Further, after the user observation is finished, the sample is extruded out of the cavity by pressing the balloon a 6.
Further, a purging liquid is placed out of the needle A5, sucked into the cavity by squeezing the balloon A6, then sucked out, and repeated multiple times.
In the technical scheme, the method further comprises the following steps:
an image processing method applied to the image processing system is characterized by comprising the following steps:
step S1, fixedly arranging an image sensor chip 2 in a groove A1 of a U disk device 1, so that a first contact electrode of the U disk device 1 is correspondingly connected with a second contact electrode of the image sensor chip 2;
step S2, acquiring image data of a sample to be observed through the image sensor chip 2, and sending the image data to the U disk device 1 through the second contact electrode and the first contact electrode in an electric signal mode;
step S3, the usb disk device 1 converts the electrical signal to form communication data suitable for sending to the processing device 3, and sends the communication data to the processing device 3 through the pluggable data transmission interface A3;
in step S4, the processing device 3 processes the communication data and displays the processing result.
The technical scheme of the invention has the beneficial effects that: the direct projection microscopic imaging is carried out on the biological cell sample by utilizing the nanoscale pixel size and hundred million pixel scale image sensor chip, and the requirements of high resolution and large field of view are met; meanwhile, the microscope device in the technical scheme has the advantages of simple overall structure, small size, portability and simplicity, can greatly improve the observation efficiency of biological cells, and reduces the technical requirements on observers.
While the invention has been described with reference to a preferred embodiment, it is to be understood that the invention is not limited to the disclosed embodiment, but is intended to cover various modifications, equivalents and obvious changes which may be made therein by those skilled in the art.
Claims (10)
1. An image processing system, comprising:
the USB flash disk device comprises a USB flash disk device, wherein a groove is formed in the upper surface of the USB flash disk device, and a plurality of first contact electrodes are arranged at the bottom of the groove;
the lower surface of the image sensor chip is provided with a plurality of second contact electrodes, when the image sensor chip is fixed in the groove, the first contact electrodes and the second contact electrodes are in one-to-one corresponding contact, the upper surface of the image sensor chip is provided with a microfluidic module, and a sample to be observed is placed in the microfluidic module;
the USB flash disk device is accessed to the processing device through a pluggable data transmission interface;
the U disk device further comprises:
and the signal conversion unit is respectively connected with the first contact electrode and the data transmission interface, and is used for converting the electric signal acquired by the first contact electrode into communication data and sending the communication data to the processing device from the data transmission interface for processing, and converting the communication data acquired by the data transmission interface into an electric signal and sending the electric signal to the image sensor chip through the first contact electrode.
2. The image processing system according to claim 1, wherein when the image sensor chip is fixed in the recess, a transmitting electrode of the first contact electrodes is in corresponding contact with a receiving electrode of the second contact electrodes, and a receiving electrode of the first contact electrodes is in corresponding contact with a transmitting electrode of the second contact electrodes;
the signal conversion unit includes:
one end of the level conversion circuit is respectively connected with the receiving electrode and the transmitting electrode in the first contact electrode, and the level conversion circuit is used for converting an electric signal and a serial port signal;
the first conversion circuit is connected between one end of the level conversion circuit and the data transmission interface and is used for converting the serial port signal into a digital signal and sending the digital signal to the processing device through the data transmission interface;
and the second conversion circuit is connected between the other end of the level conversion circuit and the data transmission interface and is used for converting the digital signal sent by the processing device into a serial port signal and sending the serial port signal to the level conversion circuit.
3. The image processing system of claim 2, wherein the image sensor chip comprises:
the first control unit is used for controlling the image sensor chip to work;
the processing device comprises:
the second control unit is used for outputting a control signal through the data transmission interface, and the control signal is transmitted to the first control unit of the image sensor chip through the U disk device so as to indicate the first control unit to control the working state of the image sensor chip;
the processing unit is used for receiving and processing the communication data through the data transmission interface;
and the display unit is connected with the processing unit and used for displaying the processing result of the processing unit.
4. The image processing system of claim 1, wherein when the image sensor chip is fixed in the recess, the power supply electrode of the first contact electrode is in corresponding contact with the power supply electrode of the second contact electrode, and the U disk device supplies power to the image sensor chip through the first contact electrode and the second contact electrode.
5. The image processing system of claim 1, further comprising an imaging support system, the imaging support system comprising:
the light source is fixedly arranged on one side of the U disk device, and a collimating device is arranged on the emergent surface of the light source and is used for collimating emergent rays of the light source into collimated rays parallel to the upper surface of the image sensor chip;
the reflecting mirror is fixedly arranged on the upper surface of the U-disk device and forms a fixed angle with the upper surface, and the reflecting surface of the reflecting mirror faces the upper surface of the image sensor chip arranged in the groove and is used for reflecting the collimated light and forming incident light which vertically enters the upper surface of the image sensor chip.
6. The image processing system of claim 1, wherein the lower surface of the U disk device is further provided with a plurality of adjustable feet for adjusting the height of the U disk device.
7. The image processing system of claim 1, wherein the microfluidic module has a cover body, the cover body and the upper surface of the image sensor chip form a cavity, and the sample to be observed is loaded in the cavity.
8. The image processing system of claim 7, wherein the microfluidic device has a liquid inlet and a liquid outlet, the liquid inlet communicating with the liquid outlet and the cavity;
the liquid inlet is used for injecting the sample to be observed in a liquid state or cleaning liquid into the cavity;
the liquid outlet is used for extracting the sample to be observed or the cleaning liquid in a liquid state from the interior of the cavity.
9. The image processing system of claim 8, wherein the liquid inlet is connected to a sampling needle, and the liquid outlet is connected to a balloon, and the sample to be observed or the cleaning solution in a liquid state is sucked from the liquid inlet by pressing the balloon.
10. An image processing method applied to the image processing system according to any one of claims 1 to 9, comprising:
step S1, an image sensor chip is fixedly arranged in a groove of a U disk device, so that a first contact electrode of the U disk device is correspondingly connected with a second contact electrode of the image sensor chip;
step S2, acquiring image data of a sample to be observed through the image sensor chip, wherein the image data is sent to the U disk device through the second contact electrode and the first contact electrode in an electric signal mode;
step S3, the U disk device converts the electric signal to form communication data suitable for being sent to a processing device, and sends the communication data to the processing device through a pluggable data transmission interface;
step S4, the processing device processes the communication data and displays the processing result.
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