CN112220846A

CN112220846A - Traditional Chinese medicine composition for treating children's chronic cough and application thereof

Info

Publication number: CN112220846A
Application number: CN202011329568.XA
Authority: CN
Inventors: 金玥; 刘红
Original assignee: QINGPU CHINESE MEDICINE HOSPITAL
Current assignee: QINGPU CHINESE MEDICINE HOSPITAL
Priority date: 2020-11-24
Filing date: 2020-11-24
Publication date: 2021-01-15

Abstract

The invention relates to a traditional Chinese medicine composition for treating children's chronic cough and application thereof, wherein the traditional Chinese medicine composition is prepared from the following raw material medicines in parts by weight: 6 parts of asarum, 5 parts of euphorbia kansui, 3 parts of fried white mustard seed, 3 parts of ephedra, 3 parts of myrobalan, 3 parts of astragalus, 3 parts of bighead atractylodes rhizome, 3 parts of salvia miltiorrhiza, 3 parts of each of radix adenophorae, 2 parts of earthworm, 2 parts of cortex dictamni and 3 parts of cinnamon. The invention also comprises application of the traditional Chinese medicine composition in preparing a patch for treating infantile chronic cough. Its advantages are: in the formula, asarum and euphorbia kansui are used as monarch drugs, semen sinapis alba and ephedra are used as ministerial drugs, myrobalan, astragalus mongholicus, bighead atractylodes rhizome, red-rooted salvia root, radix adenophorae, earthworm and cortex dictamni are used as adjuvant drugs, cinnamon is used as conductant drug, the drugs act synergistically, the traditional Chinese medicine composition is prepared into an acupoint application, and the odor of the traditional Chinese medicine composition is utilized to directly reach channels through skin acupoints and is absorbed in the body, and the traditional Chinese medicine composition is dissolved in body fluid to achieve double effects of medicine effect and acupoint.

Description

Traditional Chinese medicine composition for treating children's chronic cough and application thereof

Technical Field

The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition for treating children's chronic cough and application thereof.

Background

Cough and asthma is a common disease and a plurality of diseases of children clinically, the modern medicine considers that the exact pathogenesis is not completely clear, the pathogenesis is the result of the comprehensive action of a plurality of factors, and the low immune function is considered to be one of the important causes of the disease.

The clinical manifestations are mostly:

1. cough and asthma in children is persistent or recurrent for more than 1 month, and is often manifested as functional cough and asthma at night and in the early morning, and aggravated after exercise.

2. No clinical signs of infection (such as fever) or no effect of long-term taking of antibiotics (anti-inflammatory drugs).

3. Bronchodilators (aminophylline, etc.) are used to relieve cough and asthma.

Modern medicine is mainly used for treating susceptible children by supplementing zinc, calcium and vitamins, gamma globulin, thymosin, transfer factor and the like to improve the immunity of children patients, but has obvious side effects, and the long-term repeated use of large dose and intravenous administration can damage viscera and blood vessels of human bodies, particularly can cause certain microorganisms to generate drug resistance to drugs and even promote the generation of super bacteria. The oral administration, western medicine and injection of Chinese medicine are not easy to be accepted by children, but the effect is not ideal enough for the lack of targeted treatment of individual constitutions. The medicament can be used for preventing and treating recurrent respiratory tract infection by a susceptible formula, and avoids toxic and side effects caused by long-term administration of western medicines. Therefore, a traditional Chinese medicine preparation which has small toxic and side effect and quick curative effect and is suitable for the mouth feel of children and used for preventing and treating recurrent respiratory tract infection is urgently needed.

Chinese patent application CN201610943919.3 discloses a traditional Chinese medicine for treating children's cough caused by exogenous pathogens and a preparation method thereof, which comprises 10 to 15 weight parts of fried white mustard seed, 10 to 12 weight parts of blackberrykiky rhizome, 8 to 10 weight parts of corydalis tuber, 6 to 8 weight parts of asarum and 6 to 8 weight parts of liquorice, and overcomes many defects of western medicines. However, the traditional Chinese medicine composition for treating infantile chronic cough and the application thereof are not reported at present.

Disclosure of Invention

The invention aims to provide a traditional Chinese medicine composition for treating children's chronic cough and application thereof, aiming at the defects of the prior art.

In order to achieve the purpose, the invention adopts the technical scheme that:

firstly, the invention provides a traditional Chinese medicine composition for treating infantile chronic cough, which comprises the following raw material medicines in parts by weight: 4-8 parts of asarum, 3-7 parts of euphorbia kansui, 1-5 parts of fried white mustard seed, 1-5 parts of ephedra, 1-5 parts of myrobalan, 1-5 parts of astragalus, 1-5 parts of bighead atractylodes rhizome, 1-5 parts of salvia miltiorrhiza, 1-5 parts of adenophora tetraphylla, 1-5 parts of radix glehniae, 1-3 parts of earthworm, 1-3 parts of cortex dictamni and 1-5 parts of cinnamon.

Preferably, the traditional Chinese medicine composition consists of the following raw material medicines in parts by weight: 6 parts of asarum, 5 parts of euphorbia kansui, 3 parts of fried white mustard seed, 3 parts of ephedra, 3 parts of myrobalan, 3 parts of astragalus, 3 parts of bighead atractylodes rhizome, 3 parts of salvia miltiorrhiza, 3 parts of adenophora tetraphylla, 3 parts of radix glehniae, 2 parts of earthworm, 2 parts of cortex dictamni and 3 parts of cinnamon.

Further, the traditional Chinese medicine composition is prepared into a clinically acceptable pharmaceutical preparation according to a conventional traditional Chinese medicine preparation method.

Preferably, the pharmaceutical preparation comprises an oral preparation and an external preparation.

Preferably, the oral preparation comprises granules, powder, capsules, tablets, mixture or oral liquid.

Preferably, the external preparation comprises a paste, a powder, a lotion, a spray or a gel.

Secondly, the invention provides the application of the traditional Chinese medicine composition in preparing a medicine for treating the infantile chronic cough.

Further, the invention provides application of the traditional Chinese medicine composition in preparing a medicine for treating qi-yin deficiency type children chronic cough.

Finally, the invention provides a medicine for treating children's chronic cough, which is prepared from the traditional Chinese medicine composition, and the preparation method of the oral preparation comprises the following steps:

(1) taking the raw materials according to the weight part ratio, adding water, and decocting over strong fire for 0.5-1.5 hours;

(2) decocting with slow fire for 20-40 min;

(3) and (4) leaching out juice, precipitating, taking clear liquid, and bottling for later use.

Further, the invention provides an acupoint application for treating infantile chronic cough, which is prepared from the traditional Chinese medicine composition and ginger juice, and the preparation method of the acupoint application comprises the following steps:

(1) the raw materials are taken according to the weight part ratio, dried, ground and sieved by a 100-mesh sieve;

(2) concocting with succus Zingiberis recens.

Preferably, the point application is for the lung acupoint, gaohuang, heavenly process, and danzhong.

Square solution:

chronic cough in children is usually manifested as qi-yin deficiency. Mainly involving the lung, spleen and kidney. Common causes are cough variant asthma, upper airway cough syndrome, cough after respiratory tract infection, etc. (cough >4 weeks, no abnormality in X chest radiograph). The invention researches the acupoint application of traditional Chinese medicine, the principle of acupoint application for treating internal diseases, the principle of external treatment, namely the principle of internal treatment, and the medicine of external treatment, namely the medicine of internal treatment, on the basis of the principle of external treatment in Ri 28729and the parallel text. The smell of herbs can reach the meridians through the skin acupoints and enter the body, where it can be dissolved in the body fluids, thus playing the dual effects of drug action and acupoint effect. Chronic cough, phlegm accumulation and recurrent cough. In the formula, asarum herb warms lung and dissipates fluid, euphorbia kansui is bitter and cold and enters twelve meridians, can drain dampness of kidney channels, is also a monarch drug for treating cough and asthma due to adverse flow of qi, semen brassicae can dissipate phlegm outside the skin-lining membrane, and ephedra herb ventilates lung and relieves asthma to help monarch drugs. Myrobalan, radix adenophorae, astragalus mongholicus, bighead atractylodes rhizome and salvia miltiorrhiza bunge have the effects of astringing lung and nourishing yin, tonifying middle-jiao and qi, and activating blood and dissipating blood stasis; the collaterals are damaged by long-term illness, the herb and wood products are difficult to take effect, but the lumbricus cannot reach the effect; the theory that the root of Dictamnus dasycarpus is also called "lung governs skin hair", and "bark reaches skin", and "skin membrane treats both diseases" is also adopted. Rou Gui is used to assist in the action of herbs.

The invention has the advantages that:

the prescription is characterized in that asarum and euphorbia kansui are used as monarch drugs, fried white mustard seed and ephedra are used as ministerial drugs, myrobalan, astragalus, bighead atractylodes rhizome, salvia miltiorrhiza, radix adenophorae, earthworm and cortex dictamni are used as adjuvant drugs, and cinnamon is used as a guiding drug, so that the synergistic effect of the drugs is achieved, and no obvious toxic or side effect exists. In addition, the Chinese medicinal composition can be prepared into acupoint application, greatly improves the acceptability of children patients compared with oral preparations, and has the advantages of low cost, good curative effect, strong practicability and wide application prospect.

Detailed Description

The invention will be further illustrated with reference to specific embodiments. It should be understood that these examples are for illustrative purposes only and are not intended to limit the scope of the present invention. Furthermore, it should be understood that various changes and modifications can be made by those skilled in the art after reading the disclosure of the present invention, and equivalents fall within the scope of the appended claims.

EXAMPLE 1 Chinese medicinal composition 1

4 parts of asarum, 3 parts of euphorbia kansui, 1 part of fried white mustard seed, 1 part of ephedra, 1 part of myrobalan, 1 part of astragalus, 1 part of bighead atractylodes rhizome, 1 part of salvia miltiorrhiza, 1 part of adenophora tetraphylla, 1 part of radix glehniae, 1 part of earthworm, 1 part of cortex dictamni and 1 part of cinnamon.

EXAMPLE 2 Chinese medicinal composition (II)

Asarum herb 8 parts, kansui root 7 parts, fried white mustard seed 5 parts, ephedra herb 5 parts, myrobalan fruit 5 parts, astragalus root 5 parts, white atractylodes rhizome 5 parts, salvia miltiorrhiza 5 parts, adenophora tetraphylla 5 parts, glehnia root 5 parts, earthworm 3 parts, dittany bark 3 parts and cinnamon 5 parts.

EXAMPLE 3 Chinese medicinal composition (III)

4 parts of asarum, 7 parts of euphorbia kansui, 1 part of fried white mustard seed, 5 parts of ephedra, 1 part of myrobalan, 5 parts of astragalus, 1 part of bighead atractylodes rhizome, 5 parts of salvia miltiorrhiza, 1 part of adenophora tetraphylla, 5 parts of radix glehniae, 1 part of earthworm, 3 parts of cortex dictamni and 1 part of cinnamon.

EXAMPLE 4 Chinese medicinal composition (IV)

Asarum herb 8 parts, kansui root 3 parts, stir-fried white mustard seed 5 parts, ephedra herb 1 part, myrobalan fruit 5 parts, astragalus root 1 part, white atractylodes rhizome 5 parts, salvia miltiorrhiza 1 part, adenophora tetraphylla 5 parts, radix glehniae 1 part, earthworm 3 parts, dittany bark 1 part and cinnamon 5 parts.

EXAMPLE 5 Chinese medicinal composition (V)

6 parts of asarum, 5 parts of euphorbia kansui, 3 parts of fried white mustard seed, 3 parts of ephedra, 3 parts of myrobalan, 3 parts of astragalus, 3 parts of bighead atractylodes rhizome, 3 parts of salvia miltiorrhiza, 3 parts of adenophora tetraphylla, 3 parts of radix glehniae, 2 parts of earthworm, 2 parts of cortex dictamni and 3 parts of cinnamon.

Example 6 decoction

The preparation method comprises the following steps: the raw materials are taken according to the weight portion ratio of any one of embodiments 1 to 5 respectively, water is added, the mixture is decocted for 0.5 to 1.5 hours with strong fire and decocted for 20 to 40 minutes with slow fire, juice is drained, clear liquid is obtained through precipitation, and the mixture is bottled for standby.

Example 7 tablets/capsules

The preparation method comprises the following steps: taking the raw materials according to the weight part ratio of any one of the embodiments 1-5 respectively, adding water, decocting with strong fire for 0.5-1.5 hours, decocting with slow fire for 20-40 minutes, filtering, concentrating the filtrate, and cooling to room temperature; taking supernatant, and concentrating to obtain thick extract; adding pharmaceutical adjuvants, vacuum drying, pulverizing, granulating, and making into tablet or capsule.

Example 8 granules

The preparation method comprises the following steps: taking the raw materials according to the weight part ratio of any one of the embodiments 1-5 respectively, adding water, decocting with strong fire for 0.5-1.5 hours, decocting with slow fire for 20-40 minutes, draining juice, filtering, concentrating the filtrate, and cooling to room temperature; concentrating the supernatant, adding water, stirring, standing, and concentrating the supernatant into fluid extract. Taking the clear paste, and preparing into granules.

Example 9 Point application

The preparation method comprises the following steps: the raw materials are taken according to the weight part ratio of any one of the embodiments 1 to 5 respectively, dried, ground, sieved by a 100-mesh sieve and blended by ginger juice. Note: the acupoint application is used for lung acupoint, gaohuang, heavenly prominence and cowy middle acupoint.

Example 10 pharmacological toxicity test

1. Acute toxicity test

Acute toxicity experiments using mice show that: the traditional Chinese medicine preparation capsule of the invention is orally taken by mice, under the dosage of 332.5g crude drugs/kg, the mice have slight activity reduction after administration, the mice recover to normal after about 1 hour, no animal dies after continuous observation for 7 days after administration, the general condition, diet, water intake, urination and weight increase are all normal, and the experimental result shows that: the maximum dosage of the traditional Chinese medicine preparation capsule of the invention for oral gavage of mice is 332.5g crude drug/kg/d (LD50 is more than 332.5g crude drug/kg). The total daily clinical medication amount of the traditional Chinese medicine preparation is 0.1g crude drugs/kg/d; according to the weight, the tolerance of the traditional Chinese medicine preparation for intragastric administration of the mice is 3325 times of that of clinical patients. The medicine has low acute toxicity and safe clinical medication.

2. Long term acute toxicity test

SD rats are selected, pills of the traditional Chinese medicine preparation of the invention with different concentrations (18.0, 6.0 and 2.0g crude drug/kg) are administered, the stomach is drenched once a day for 90 days continuously, 1/2 animals (half of a male and a female) are killed in each group 24 hours after the last administration, and the rest 1/2 animals are killed after 2 weeks of continuous observation. The animals were observed for changes in appearance, general behavior, food intake, and body weight during the test period, and examined for indices of hematology (RBC, HB, reticulocyte, PLT, CT, WBC, and classification) and blood biochemistry (AST, ALT, ALP, Glu, BUN, Crea, TP, T.BIL, ALB, CHOL), urine biochemistry, organ coefficients, histopathology, etc. 90 days after administration and 2 weeks after discontinuation. The test result shows that: the traditional Chinese medicine preparation has good general state in high, medium and low dose animals, and has no abnormal change in appearance physical signs, behavior activity, food intake and weight growth; the three dose groups and the control group are in normal range of hematology examination, blood biochemistry examination and urine biochemistry examination, and have no obvious difference among the groups; no obvious abnormality is found in histopathological examination of main organs of each group. The above index was not changed after 2 weeks of withdrawal. The test dosage is 180, 60 and 20 times of the clinical dosage, and according to the test result, the continuous administration of the traditional Chinese medicine preparation for 90 days at high, medium and low dosages (18.0, 6.0 and 2.0g crude drug/kg) has no obvious influence on rats, has no clear toxic target organs and sensitive indexes, has no delayed toxic reaction in the observation of the recovery period, and prompts that the clinical application dosage of the traditional Chinese medicine preparation has higher safety.

3. SD rats are selected, and are administrated with the traditional Chinese medicine preparation of the invention with different concentrations (18.0, 6.0 and 2.0g crude drug/kg), and are irrigated once a day for 90 days continuously, and 1/2 animals (half of a female and a half of a male) are killed in each group 24 hours after the last administration, and the rest 1/2 animals are killed after continuously observing for 2 weeks. The animals were observed for changes in appearance, general behavior, food intake, and body weight during the test period, and examined for indices of hematology (RBC, HB, reticulocyte, PLT, CT, WBC, and classification) and blood biochemistry (AST, ALT, ALP, Glu, BUN, Crea, TP, T.BIL, ALB, CHOL), urine biochemistry, organ coefficients, histopathology, etc. 90 days after administration and 2 weeks after discontinuation. The test result shows that: the traditional Chinese medicine preparation has good general state in high, medium and low dose animals, and has no abnormal change in appearance physical signs, behavior activity, food intake and weight growth; the three dose groups and the control group are in normal range of hematology examination, blood biochemistry examination and urine biochemistry examination, and have no obvious difference among the groups; no obvious abnormality is found in histopathological examination of main organs of each group. The above index was not changed after 2 weeks of withdrawal. The test dosage is 180, 60 and 20 times of the clinical dosage, and according to the test result, the continuous administration of the traditional Chinese medicine preparation for 90 days at high, medium and low dosages (18.0, 6.0 and 2.0g crude drug/kg) has no obvious influence on rats, has no clear toxic target organs and sensitive indexes, has no delayed toxic reaction in the observation of the recovery period, and prompts that the clinical application dosage of the traditional Chinese medicine preparation has higher safety.

EXAMPLE 11 clinical trial

1 data of

1.1 clinical data

332 patients in the hospital visit from 5 months in 2018 to 3 months in 2020 are selected, and are divided into six groups by a random number table method, wherein the six groups are respectively a treatment group, a comparative example group three group, a comparative example group four group, a comparative example group five group and a control group. Before treatment, patients in each group have no significant difference in sex, age, disease course and the like, and have good balance among groups and comparability.

1.2 diagnostic criteria

Refer to the diagnosis standard in the latest edition of Chinese guidelines for children chronic cough diagnosis and treatment revised in 2013.

1.3 inclusion criteria

(1) Meets the above diagnostic criteria;

(2) the age is 2-14 years, and male and female are not limited;

(3) the subject parents sign an informed consent.

1.4 rejection criteria:

cases that were misincorporated without meeting inclusion criteria; cases that were not treated with the study protocol after inclusion, although meeting inclusion criteria; the abscission cases stopped in the middle of the test due to non-curative effect reasons and adverse reactions; adding other medicines; the data is not complete and cannot be counted.

1.5 termination and withdrawal of clinical trial standards

Other diseases appear in the test, affecting the test performers; other situations are not foreseeable.

2 method

2.1 methods of treatment

Treatment groups: the acupoint application is prepared from the traditional Chinese medicine composition in the weight portion in example 5, and the acupoint application comprises the following steps: lung Yu, Gaohuang, Tiantu, Danzhong. Applied twice a week, 3 times as a course of treatment. The application should not be used for bathing within three days, and should be kept locally clean. Any other herbs should not be used during the treatment period, and raw, cold, pungent and pungent herbs should not be eaten.

Comparative example one set: taking the traditional Chinese medicine composition: asarum herb 3 parts, kansui root 2 parts, fried white mustard seed 6 parts, ephedra herb 6 parts, myrobalan fruit 6 parts, astragalus root 6 parts, white atractylodes rhizome 6 parts, salvia miltiorrhiza 6 parts, adenophora tetraphylla 6 parts, radix glehniae 7 parts, earthworm 5 parts, dittany bark 4 parts and cinnamon 7 parts, and the acupoint application is prepared. Acupoint application: lung Yu, Gaohuang, Tiantu, Danzhong. Applied twice a week, 3 times as a course of treatment. The application should not be used for bathing within three days, and should be kept locally clean. Any other herbs should not be used during the treatment period, and raw, cold, pungent and pungent herbs should not be eaten.

Comparative examples two groups: taking the traditional Chinese medicine composition: asarum herb 4 parts, kansui root 7 parts, white mustard seed 1 part, Chinese ephedra 5 parts, myrobalan 1 part and astragalus root 5 parts, and the plaster is prepared into acupoint application. Acupoint application: lung Yu, Gaohuang, Tiantu, Danzhong. Applied twice a week, 3 times as a course of treatment. The application should not be used for bathing within three days, and should be kept locally clean. Any other herbs should not be used during the treatment period, and raw, cold, pungent and pungent herbs should not be eaten.

Comparative three groups: taking the traditional Chinese medicine composition: 1 part of largehead atractylodes rhizome, 5 parts of danshen root, 1 part of adenophora tetraphylla, 5 parts of coastal glehnia root, 1 part of earthworm, 3 parts of cortex dictamni and 1 part of cinnamon, and the plaster is prepared into acupoint application. Acupoint application: lung Yu, Gaohuang, Tiantu, Danzhong. Applied twice a week, 3 times as a course of treatment. The application should not be used for bathing within three days, and should be kept locally clean. Any other herbs should not be used during the treatment period, and raw, cold, pungent and pungent herbs should not be eaten.

Comparative example four groups: taking the traditional Chinese medicine composition: asarum herb 4 parts, euphorbia root 7 parts, cassia bark 1 part, ledebouriella root 5 parts, myrobalan fruit 1 part, astragalus root 5 parts, dahurian angelica root 1 part, ophiopogon root 5 parts, adenophora root 1 part, glehnia root 5 parts, cornus officinalis 1 part, stemona root 3 parts, Cinnamomum cassia 1 part and anemarrhena rhizome 1 part, and making into acupoint plaster. Acupoint application: lung Yu, Gaohuang, Tiantu, Danzhong. Applied twice a week, 3 times as a course of treatment. The application should not be used for bathing within three days, and should be kept locally clean. Any other herbs should not be used during the treatment period, and raw, cold, pungent and pungent herbs should not be eaten.

Control group: yumei granules, the using method is as follows: refer to the description.

2.2 criteria for therapeutic efficacy

And (3) curing: clinical symptoms and physical signs disappear completely, and the auscultation breathing sound of the two lungs is clear.

The effect is shown: the clinical symptoms and physical signs basically disappear, and the auscultation of the respiratory sounds of the two lungs is clear.

The method has the following advantages: has improved clinical symptoms and physical signs, and improved auscultation of respiratory sounds of both lungs.

And (4) invalidation: the clinical symptoms and physical signs are not improved, and the auscultation is unclear in the breathing of the two lungs.

And (3) relapse: respiratory tract infection does not occur within 3 months after stopping the medicine.

2.3 results

In the experiment, 10 cases are dropped out altogether, and the effective cases are 322 cases in total.

TABLE 1 comparison of therapeutic effects of the groups

3 conclusion

The results show that the total effective rate of the treatment group is highest, then four groups of comparative examples, one group of comparative examples, two groups of comparative examples and three groups of comparative examples are respectively arranged, finally the control group is arranged, the recurrence rate is lowest, the treatment group is arranged, then four groups of comparative examples, one group of comparative examples, two groups of comparative examples and three groups of comparative examples are respectively arranged, and finally the control group is arranged, wherein the total effective rate of the experiment group is obviously higher than that of the four groups of comparative examples, and the recurrence rate is obviously. The formula of the invention has the best curative effect.

In addition, the prepared acupoint application is based on principle of principal and internal treatment, and in Ri \28729andparallel, the principle of external treatment in cloud, that is, the principle of internal treatment, and the herbs of external treatment, that is, the herbs of internal treatment, are different from those of ear treatment. The smell of herbs can reach the meridians through the skin acupoints and enter the body, where it can be dissolved in the body fluids, thus playing the dual effects of drug action and acupoint effect. Chronic cough, phlegm accumulation and recurrent cough. In the formula, asarum herb warms lung and dissipates fluid, euphorbia kansui is bitter and cold and enters twelve meridians, can drain dampness of kidney channels, is also a monarch drug for treating cough and asthma due to adverse flow of qi, semen brassicae can dissipate phlegm outside the skin-lining membrane, and ephedra herb ventilates lung and relieves asthma to help monarch drugs. Myrobalan, radix adenophorae, astragalus mongholicus, bighead atractylodes rhizome and salvia miltiorrhiza bunge have the effects of astringing lung and nourishing yin, tonifying middle-jiao and qi, and activating blood and dissipating blood stasis; the collaterals are damaged by long-term illness, the herb and wood products are difficult to take effect, but the lumbricus cannot reach the effect; the theory that the root of Dictamnus dasycarpus is also called "lung governs skin hair", and "bark reaches skin", and "skin membrane treats both diseases" is also adopted. Rou Gui is used to assist in the action of herbs.

The foregoing is only a preferred embodiment of the present invention, and it should be noted that, for those skilled in the art, various modifications and additions can be made without departing from the principle of the present invention, and these should also be considered as the protection scope of the present invention.

Claims

1. The traditional Chinese medicine composition for treating children's chronic cough is characterized by comprising the following raw material medicines in parts by weight: 4-8 parts of asarum, 3-7 parts of euphorbia kansui, 1-5 parts of fried white mustard seed, 1-5 parts of ephedra, 1-5 parts of myrobalan, 1-5 parts of astragalus, 1-5 parts of bighead atractylodes rhizome, 1-5 parts of salvia miltiorrhiza, 1-5 parts of adenophora tetraphylla, 1-5 parts of radix glehniae, 1-3 parts of earthworm, 1-3 parts of cortex dictamni and 1-5 parts of cinnamon.

2. The traditional Chinese medicine composition according to claim 1, which is prepared from the following raw materials in parts by weight: 6 parts of asarum, 5 parts of euphorbia kansui, 3 parts of fried white mustard seed, 3 parts of ephedra, 3 parts of myrobalan, 3 parts of astragalus, 3 parts of bighead atractylodes rhizome, 3 parts of salvia miltiorrhiza, 3 parts of adenophora tetraphylla, 3 parts of radix glehniae, 2 parts of earthworm, 2 parts of cortex dictamni and 3 parts of cinnamon.

3. The Chinese medicinal composition according to any one of claims 1 to 2, which is prepared into a clinically acceptable medicinal preparation according to a conventional Chinese medicinal preparation method.

4. The traditional Chinese medicine composition of claim 3, wherein the pharmaceutical preparation comprises an oral preparation and an external preparation.

5. The Chinese medicinal composition according to claim 4, wherein the oral preparation comprises granules, powder, capsules, tablets, mixture or oral liquid.

6. The composition of claim 4, wherein the external preparation comprises a paste, a powder, a lotion, a spray or a gel.

7. Use of the Chinese medicinal composition of any one of claims 1-2 in the preparation of a medicament for treating infantile chronic cough.

8. The use of the Chinese medicinal composition of any one of claims 1-2 in the preparation of a medicament for treating qi and yin deficiency type chronic cough in children.

9. A medicine for treating infantile chronic cough, which is prepared from the traditional Chinese medicine composition of any one of claims 1-2, and the preparation method of the oral preparation comprises the following steps:

(2) decocting with slow fire for 20-40 min;

10. An acupoint application for treating infantile chronic cough, which is prepared from the traditional Chinese medicine composition of any one of claims 1-2 and ginger juice, and the preparation method of the acupoint application comprises the following steps:

(2) blending with ginger juice;

the acupoint application is used for lung acupoint, gaohuang, heavenly prominence and cowy middle acupoint.