CN112168913A

CN112168913A - Pure Chinese medicinal preparation capable of strengthening body and delaying aging and preparation method thereof

Info

Publication number: CN112168913A
Application number: CN202011163315.XA
Authority: CN
Inventors: 王忠诚
Original assignee: Individual
Current assignee: Individual
Priority date: 2020-10-27
Filing date: 2020-10-27
Publication date: 2021-01-05

Abstract

The invention belongs to the technical field of medicines, and particularly relates to a pure traditional Chinese medicine preparation capable of strengthening body and delaying senescence and a preparation method thereof. The pure traditional Chinese medicine preparation comprises a component A and a component B, wherein the component A is selected from at least one of chalk, calcite, cretinite or oyster, the component B is selected from at least one of senna leaf or aloe vera, and the component A also comprises ophicalcite. The chalk, the ophicalcitum, the calcite, the quintocarpium, the oyster, the senna leaf and the old aloe are mutually cooperated, calcium ions and magnesium ions are formed in the stomach after the chalk, the ophicalcitum, the calcite, the senna leaf and the old aloe are taken, the calcium ions and the magnesium ions are easily absorbed and utilized, and the aims of strengthening the body and keeping healthy and delaying senility are achieved by supplementing the calcium ions and the magnesium ions.

Description

Pure Chinese medicinal preparation capable of strengthening body and delaying aging and preparation method thereof

Technical Field

The invention belongs to the technical field of medicines, and particularly relates to a pure traditional Chinese medicine preparation capable of strengthening body and delaying senescence and a preparation method thereof.

Background

The third national nutrition survey shows that: the calcium intake of Chinese people is generally insufficient, the average daily calcium intake of each person is less than 400mg, the calcium intake is less than 50% of the recommended amount of the nutrition society, the calcium deficiency phenomenon of children and teenagers is more serious, and the calcium intake of 70% -80% of people is insufficient.

At present, the dietary structure of China belongs to the low-calcium category, and according to investigation, the ordinary diet of Chinese people can only meet 2/3 of the physiological requirement of human bodies on calcium, in addition, 1/3 needs additional supplement, and data shows that more than 90 percent of people in China are in calcium deficiency. At present, calcium supplements with various names are available on the market, and calcium contained in the calcium supplements is mostly in a compound state, so that the absorption rate of human intestinal tracts is low.

Therefore, there is a need for an effective calcium-supplementing and absorbable drug that is not calcium-deficient, is more robust, and can delay aging. The preparation is characterized in that calcium ions and magnesium ions are formed in the stomach after being taken, the preparation is easy to absorb and utilize, and the purpose of strengthening the body and delaying aging can be achieved by supplementing the calcium and magnesium ions.

Disclosure of Invention

According to the ninth regulation of the regulations of the embodiment of the Chinese medicine management law: the raw material medicines used by the medicine production enterprises for producing the medicines must have the approved code of the medicines approved by the drug administration of state hospitals or the registration certificate of imported medicines and the registration certificate of medical products; however, the method is not limited to Chinese medicinal materials and Chinese medicinal decoction pieces which are not subjected to approved document management. The required raw material medicaments are selected. According to the regulation, the invention selects the traditional Chinese medicine decoction pieces: selected from chalk, ophicalcitum, calcite, penta-lith, oyster, and senna and aloe vera.

According to the tenth regulation of the regulations of the embodiment of the national drug management method of people's republic of China: according to the thirteenth rule of the drug administration act, the drug manufacturer who accepts the drug to be produced by the consignment must have a certification of drug production quality control code corresponding to the drug to be produced by the consignment. Vaccines, blood products and other drugs prescribed by the drug administration of the State Council are not mandated. The preparation and production of the medicine are carried out. According to the invention, the medicine enterprises meeting the specification are selected to be entrusted to the preparation and production of the medicines.

The technical problem to be solved by the invention is as follows: the invention overcomes the defects of the prior art, provides a pure traditional Chinese medicine preparation which can strengthen the body and delay senility, can effectively supplement calcium and magnesium and relieve symptoms caused by calcium and magnesium deficiency, thereby ensuring the body to be healthy and delaying senility, and simultaneously provides a preparation method thereof, which is scientific and precise, simple and easy to operate.

The pure traditional Chinese medicine preparation capable of strengthening the body and delaying senescence comprises an A component and a B component, wherein the A component is selected from at least one of chalk, calcite, cretini or oyster, and the B component is selected from at least one of senna leaf or aloe vera.

Preferably, the mass ratio of the A component to the B component is 1: 1.

Preferably, the A component also comprises ophicalcitum. The Ophicalcitum is compounded with at least one of chalk, calcite, pentasil, or Concha Ostreae.

Further, the pure herbal preparation for strengthening body and delaying aging comprises chalk, ophicalcitum, calcite, ichthammol, oyster, senna and aloe vera. The mass ratio of the chalk, the ophicalcitum, the calcite, the marbled, the oyster, the senna leaf and the old aloe is 1:2:3:3:1:5: 5.

The dosage of the medicines is determined according to the property characteristics of the medicines so as to improve the advantages and avoid the disadvantages, meanwhile, the medicines are close in pharmacology, combined together, and the potency is superposed, so that the effect of 1+1 being more than 2 can be obtained.

The preparation method of the pure traditional Chinese medicine preparation capable of strengthening body and delaying senility comprises the following steps:

(1) respectively selecting the raw materials in the component A, removing impurities, drying in the air, respectively metering, mixing the materials, crushing, drying, sterilizing and grinding to obtain mixed powder A;

(2) selecting the raw materials in the component B respectively, removing impurities, drying in the air, and then performing ozone sterilization and grinding to obtain mixed powder B;

(3) mixing the prepared mixed powder A and the prepared mixed powder B, homogenizing and qualifying to prepare the pure Chinese medicinal preparation which can strengthen the body and delay senility.

Preferably, the drying and sterilizing temperature in the step (1) is 350-450 ℃, and the particle size of the mixed powder A is less than 800 meshes.

Preferably, the particle size of the mixed powder B in the step (2) is less than 800 meshes.

Preferably, the dosage form of the preparation in the step (3) is any pharmaceutically acceptable dosage form, such as powder, pills, tablets or capsules. Preferably tablets, the packaging specification is 500 mg/tablet, two plates per box, 20 plates per plate, aluminum plastic sealing, or 60 plates per bottle, and the bottles are filled with high-density polyethylene. The medicine packaging regulation in chapter six of the medicine management law of the people's republic of China must be met, and the medicine packaging regulation is realized by a trusted medicine enterprise.

The research and development process is as follows: the intestine and stomach of the applicant are bad in young, the body is weak and sick, the applicant is hospitalized for many times due to various diseases, the work is carried out for more than thirty years, the hospitalization time is accumulated for about ten years, the leg cramps are also caused, the doctor says that the calcium is deficient, the applicant pays attention to calcium supplement, and the applicant tries to supplement the calcium by using a plurality of calcium sources, and uses eggshells, various shells (clam shells, scallop shells, oyster shells, rainbow shells, conch shells and the like) and bones such as fish bones, fish bones and the like successively, and the eggshells, the shells, the clam shells, the scallop shells, the oyster. Later, calcium carbonate powder (including ground calcium carbonate and artificial light calcium carbonate) and chalk powder and penta-color gypsum powder are taken, but the chalk powder and the penta-color gypsum powder are difficult to purchase at present, so that the ophicalcitum powder and the calcite powder are taken again, and the effect is good.

In the father of modern western medicine of Greek famous physicians, Hibock sole indicates that all diseases begin in the intestines in the third century of the Ministry, which is quite correct, and indicates how people should go to a healthy way. [ Mei ] Prov. Perlmatt (David Perlmuter)/Kristin Loberg (Kristin Loberg) ]Courospora cerebrum: the astonishing truth that intestinal microorganisms affect brain and physical and mental health in page 185 of the patent document 'unusual way' inspires great inspiration for the applicant, is used by the applicant, is combined with health services nowadays, and then senna leaves and old aloe are selected. The composition is compatible with chalk, ophicalcitum, calcite, quintocyte and oyster to prepare a pure Chinese medicinal preparation, after the composition is taken, the gastrointestinal and the whole body can feel very relieved, the flatulence disappears for many years, and the dry stool caused by taking the chalk, ophicalcitum, calcite, quintocyte and oyster is also relieved.

The following is the pharmaceutical principle of the invention:

medicine composition and pharmacological action

1. Calcite

Also called as calcite, another name: yellow stone (bibliographic), ore derived from carbonate mineral calcite, is collected to remove miscellaneous mud and stones; the chemical composition mainly contains calcium carbonate (CaCO)₃) In which CaO is 56%, CO₂44% and further contains small amounts of Mg, Fe, Mn and trace amounts of Zn, Sr and the like.

Medicine property: bitter and pungent taste, cold and non-toxic.

The functional indications are as follows: clearing away heat and toxic materials.

The usage method comprises the following steps: the decoction is taken orally 10-30g or is made into powder.

It is contraindicated: it should be used with cautions for those with non-excessive heat.

Taking out: a Chinese medicine dictionary (book number: ISBN978-7-5478 and 7364-5, page 599).

The pharmacological action is as follows: calcite (CaCO)₃) After being taken, the medicine reacts with gastric acid (main component HCl) to generate calcium chloride, CaCO₃+2HCl→CaCl₂+H₂CO₃。

Calcium chloride is easy to deliquesce in vivo, cannot form calculus, has no calculus risk, is easy to absorb, and can be discharged out of the body along with feces and urine.

2. Chalk (also known as white good)

Nature and taste: bitter taste, warm nature and no toxicity.

The main treatment is as follows: warm the middle energizer, astringe intestines, stop bleeding and heal wound. It is indicated for regurgitation, dysentery, hematemesis, epistaxis, red rot of eye string, ecthyma.

(I) Ben Jing: "Cold-heat syndrome of women manifested as abdominal mass, amenorrhea and accumulation. "

② Biyu (miscellaneous records): for swelling and pain of yin, there is no son on the lower abdomen, so it can stop diarrhea and promote diuresis. "

③ treatise on herb Property: "Su Zi is a disease of blood stasis in women and obstruction in the moon, and can astringe intestines to stop diarrhea and warm. "

Fourthly, Rihuazi materia Medica: it is indicated for diarrhea, dysentery, hemorrhoids and fistula, seminal emission, cold womb in women, cold water in men, and hematemesis due to nasal flood. "

Fifth, Yi Ling Du (treatise on Merrill of medicine): tonifying lung and generating gold, quenching thirst and clearing summer heat. It is indicated for lung abscess and flaccidity, red and white dysentery, and spleen and stomach. It is indicated for cholera with abdominal pain. "

It is contraindicated: the bibliography: if the traditional Chinese medicine is not taken for a long time, the traditional Chinese medicine hurts five reservoirs and makes people thin. "

Chemical components: the main component is calcium carbonate, and the inclusions comprise small amounts of aluminum silicate, magnesium silicate, calcium phosphate, iron oxide and the like.

The usage and dosage are as follows: oral administration: take pills or powder for 1.5-3X. External use: grind into powder or mix with other herbs for external application.

3. Five-color stone grease

Odor: the five kinds of the stone fat are sweet, mild and nontoxic.

The main treatment is as follows: jaundice, diarrhea, intestinal weakness, pus and blood, erosion of the yin, bleeding, red, white pathogen, qi stagnation, carbuncle, hemorrhoid, malignant sore, head sore, scabies , bone marrow supplementing, qi benefiting, body building, no hunger, body weight reducing, life prolonging, and five-color stone fat supplementing five internal organs with five colors. Shen nong Ben Cao Jing (Shen nong's herbal)

4. Oyster shell

Alias: oyster (Benjing), ancient cardia (Yang Fu (foreign body records)), oyster (Bu Xia Hou Fang (rear elbow of Bu-Chu), oyster (Bian Bing (records separately)), oyster house, oyster (Ben Cao Tu Jing), oyster shell (Zhejiang Chinese materia Medica), oyster shell, oyster peel (Shandong Chinese materia Medica), and left shell (Chi Zhi).

Odor: salty, mild, slightly cold and nontoxic.

The functional indications are as follows: astringe yin, subdue yang, check sweating, astringe essence, resolve phlegm and soften hard masses. It is indicated for fright epilepsy, vertigo, spontaneous perspiration, night sweat, seminal emission, stranguria with turbid urine, metrorrhagia, leukorrhagia, scrofula and goiter. Can be used for treating palpitation, insomnia, vertigo, tinnitus, scrofula, subcutaneous nodule, lump in the abdomen, spontaneous perspiration, night sweat, nocturnal emission, metrorrhagia, gastralgia, and pantothenic acid. Calcined oyster shell astringes and astringes. Can be used for treating spontaneous perspiration, night sweat, spermatorrhea, metrorrhagia, gastralgia, and acid regurgitation.

(1) Nourishing yin and suppressing yang: unprocessed for tidal fever, night sweat, headache, vertigo, dysphoria and insomnia due to yin deficiency and yang hyperactivity.

(2) Softening hardness and dissipating nodulation: unprocessed is used for scrofula and lumps.

(3) Astringency inducing: calcined for hyperhidrosis, seminal emission, leukorrhagia, metrorrhagia and diarrhea, it is often combined with Long Gu.

(4) It can also be used for gastric hyperacidity, and is often combined with cuttlefish bone.

(I) Ben Jing: cold and heat, warm malaria and spill, fright anger anger, spasm and rat fistula and leukorrhagia of female. Strengthen the bone joint after long-term administration.

② Biyu (miscellaneous records): removing retained heat in the joints, removing deficiency heat from the joints and causing restlessness and irritability; arresting sweating, relieving heart pain, stopping thirst and removing old blood. Astringe large and small intestines, relieve constipation, treat diarrhea, throat obstruction, cough, and distention and fullness in the hypochondrium.

③ treatise on herb Property: it is used for treating metrorrhagia. Stop night sweat, dispel wind-heat and alleviate pain. It can be used for treating warm malaria. It is also combined with Du Zhong to stop night sweat. For patients with deficiency syndrome and excessive heat, rehmanniae radix and herba Chloranthi Serrati can be added.

Fourthly, the materia medica is picked up and lost: pounding into powder to obtain powder for treating night sweat of adults and children, and mixing with radix Ephedrae, fructus Cnidii, and Zingiberis rhizoma to obtain powder for removing yin sweat.

Fifth, materia medica herbals of sea medicine: mainly treats spermatorrhea, consumptive disease and loss, tonifies kidney and healthy energy, prevents steatorrhea, removes dysphoria and feverish sensation, treats typhoid fever and phlegm, can nourish the body and calm the nerves, and treats infantile convulsion and epilepsy.

Sixthly, pearl sac: it is soft and has a feeling of fullness and oppression. It is also indicated for leukorrhagia, warm malaria, sores and swelling, and is a herb for softening hardness and astringing.

Seventh, the compendium: resolving phlegm and softening hard mass, clearing heat and eliminating dampness, relieving heart and spleen qi pain, dysentery, red and white turbidity, eliminating hernia and mass, goiter and tuberculosis.

'the West records of Yi Xue Zhong' comprising the following components: stop hiccup.

Ninthly modern practical traditional Chinese medicine: is an antacid, has the functions of harmonizing stomach and relieving pain, and is used for treating hyperacidity, asthenia, night sweat, palpitation, twitching, meat twitching, and the like. It is effective in treating calcium deficiency and pulmonary tuberculosis in pregnant women and children.

Chemical components: containing CaCO₃More than 90%, and organic matter about 1.72%; contains small amount of Mg, Fe, silicate, sulfate and PAcid salts and chlorides. After calcination, the carbonate decomposes to produce calcium oxide and the like, and the organic matter is destroyed.

The pharmacological action is as follows: has astringent, tranquilizing, toxic materials clearing away, and analgesic effects; the acidic extract of oyster has inhibitory effect on poliovirus in vivo, and can reduce the mortality of infected mice.

The usage and dosage are as follows: oral administration: decocting 0.3-1 times of soup; or made into pill or powder. External use: grinding, and spreading or dusting powder.

It is contraindicated: constipation and dyspepsia are easily caused by taking for a long time.

5. Senna leaf

Senna, folium sennae, and folium Phyllostachydis Henonis.

The pharmacological action is as follows:

(1) purgative effect: the folium sennae has the strongest effect of dianthrone glycosides such as sennoside A, and the second anthraquinone glycoside, free anthraquinone, is likely to be oxidized by digestive tract, so the effect is weaker; the combined glycoside has protective effect, and can be decomposed into aglycone by bacteria or enzyme when reaching large intestine, to stimulate large intestine, increase tension and peristalsis, and reduce diarrhea due to water absorption (see radix et rhizoma Rhei).

(2) And (3) antifungal: the 25% water extract has effect in inhibiting Ostreatia ozoloides and Nocardia stellate.

(3) Hemostasis: the senna leaf total anthraquinone glycoside is injected into the abdominal cavity at 200mg/kg, which has the effect of stopping the capillary method of mice.

(4) Toxicity: the content of sennoside in mice injected intraperitoneally was 1.141g/kg of LD 50.

Nature and taste: sweet, bitter, cold and slightly toxic.

Meridian tropism: it enters large intestine meridian.

The functional indications are as follows: purging heat and removing food stagnation, it is indicated for constipation due to heat accumulation and abdominal distention.

The decoction pieces are prepared as follows: "purge heat, promote bowel movement and relieve constipation. "

② modern practical traditional Chinese medicine: it is indicated for food stagnation, fullness and distention in chest and abdomen, constipation. "

③ Chinese traditional medicine plant atlas: "effective as purgative, whether chronic or temporary constipation"

The administration dosage is as follows: decocting (adding later) 1-2 coins; grinding for 0.5-1 cash; or soaking in water for oral administration.

It is contraindicated: it is contraindicated for weak health and pregnant women. ② decoction pieces new ginseng: it is contraindicated for middle cold diarrhea.

6. Aloe vera

The two names of Luhe (treatise on herb properties), the King (supplement to the materia Medica), the Feidai (Ben Cao Shi Yi), the elephant gallbladder and the Noval (Kai Bao Ben Cao), and the Lowe (Reserve for herb properties).

A base source: the source is concentrated dried product of juice from leaves of Aloe barbadensis Miller, Aloe ferox or Aloe marbled belonging to Liliaceae.

Original plants: aloe vera (aged Aloe vera).

The pharmacological action is as follows:

(1) diarrhea inducing effect.

(2) Has antibacterial effect, and can inhibit Staphylococcus and Escherichia coli. .

(3) Impact on the immune system: has anti-inflammatory effect.

(4) Has antitumor effect.

(5) Liver protecting and stomach injury resisting effects.

(6) Effect on tissue damage: has therapeutic effect.

(7) Has protective effect on skin.

(8) Other functions are as follows: stimulating the growth.

Nature and taste: bitter taste and cold nature.

Meridian tropism: it enters liver and large intestine meridians.

The functional indications are as follows: clear heat, relieve constipation and kill parasites. It is used to treat constipation due to heat accumulation, amenorrhea, infantile convulsion, infantile malnutrition, fever, insect accumulation, tinea, hemorrhoid and fistula, atrophic rhinitis, and lymphoid tuberculosis.

(xi) treatise on drug Property: can be used for treating infantile malnutrition. Blow nose and kill chancroid, and relieve itching nose.

② 'materia medica of sea medicine': it is mainly indicated for infantile malnutrition heat.

③ Kaibao Ben Cao: the main pathogenic wind smothery, the hot gas between chest and diaphragm, improving eyesight and calming heart, treating infantile epilepsy and convulsion, treating malnutrition, killing three insects, and treating hemorrhoid and fistula. And (3) removing croton toxin.

Fourthly, the "materia Medica of materia Medica": for itching due to dampness and with yellow juice; it is also indicated for hidden teeth.

Fifth, De Cang Ben Cao: to disperse scrofula, treat fright epilepsy, induce diuresis and remove edema.

Sixthly, the herbal refreshment: for liver fire, subduing liver wind, clearing away heart heat, relieving restlessness, quenching thirst, promoting fluid production, improving hearing and eyesight, eliminating dental swelling, and relieving fire toxin.

Seventhly, modern practical traditional Chinese medicines: is a drastic purgative, and has the effects of invigorating stomach and dredging meridians.

The administration dosage is as follows: take pills or powder, 0.5-1.5X. External use: grind into powder and apply.

It is contraindicated: it is contraindicated for patients with deficiency-cold of spleen and stomach and pregnant women.

Discussion of each family:

ben Cao Jing Shu (the book of materia Medica Prime and Dredging): aloe is the essential herb for removing heat and killing parasites because it can clear heat, expel heat and dry dampness, and kill parasites. It is mainly induced by hot wind, manifested as vexation, hot gas in chest and hypochondrium, vision improving, tranquilizing, and infantile epilepsy, can treat malnutrition, kill three insects, generate wind due to heat, and relieve vexation due to heat, and spontaneous decomposition of hot gas in chest and diaphragm due to heat removal. Cool liver to improve vision. Relieving restlessness and calming the heart. Infantile epilepsy, convulsions, heat transformation, and malnutrition of the five zang-fu organs are both the syndrome of stagnation of spleen and stomach; the three parasites are mainly known to be caused by damp-heat in intestines and stomach and damp-heat in hemorrhoids with sore and flaccidity, and also caused by blood stagnation due to damp-heat in intestines and stomach. It can relieve croton toxicity and also remove heat.

The book Ben Cao Hui Yan (treatise on materia Medica): the theory that the aloe has the effects of clearing liver, clearing heat, eliminating dampness and killing parasites: the marjone: luhui, liver-cooling and parasites-killing herbs. It is also used for liver with heat. But the herbs with bitter and cold taste are extremely bitter and cold in qi, so all the herbs with bitter and cold taste are not the right ones. It is indicated for internal heat because its action is mainly to eliminate and tonify, for instance, it is prohibited for diarrhea and anorexia due to internal deficiency. "

7. Ophicalcitum

Also called flower milk stone, dolomitic flavor: sour and astringent taste, mild nature and no toxicity.

Nature, flavor and meridian tropism: mild in nature, sour and astringent in taste. It enters liver meridian.

Pharmacological research: contains hydrous magnesium silicate, small amount of iron and aluminum, and more than 20 trace elements of zinc, manganese, copper, cobalt, nickel, chromium, lead and the like. Has obvious anticonvulsant effect; it also has blood coagulation and hemostatic effects.

The main treatment is as follows: metrorrhagia and metrostaxis in five interior, heavy bleeding, traumatic injury, death and abortion, falling of cell coating, and removing blood stasis, nebula for many years.

Taking out: compendium of materia Medica (book number: ISBN978-7-5046 and 7663-4/R.2111, page 68) and Chinese herbal medicine (page 1591).

Chemical components: the Ophicalcitum is mainly calcium and magnesium carbonate CaCO₃·MgCO₃And a small amount of iron salt, lead salt, elements such as zinc, copper, cobalt and the like and a small amount of acid-insoluble substances are mixed.

The pharmacological action is as follows: CaCO in ophicalcite₃·MgCO₃After taking, the mixture reacts with gastric juice (main component HCl) to generate calcium chloride, magnesium chloride and CaCO₃·MgCO₃+4HCl→CaCl₂+MgCl₂+2H₂CO₃。

The calcium chloride and the magnesium chloride are easy to deliquesce in vivo and can not form calculus, no calculus risk exists, meanwhile, the calcium chloride and the magnesium chloride are easy to be absorbed by human body, the requirement of human body on calcium and magnesium ions is supplemented, the skeleton and teeth of human body are enhanced, the body is strong, and the calcium chloride and the magnesium chloride which are not absorbed can be discharged out of the body along with the excrement and urine.

Mechanisms that can prevent cellular aging: calcium chloride, magnesium chloride and magnesium ions can influence the passage of potassium, sodium and calcium ions moving inside and outside cells after calcium carbonate and magnesium carbonate in chalk, ophicalcitum, calcite, penta-color lithangiumus and oyster are taken and react with gastric juice (main component HCl) to generate calcium chloride.

Usually, magnesium and potassium ions are distributed in intracellular slurry, and sodium and calcium ions are distributed in extracellular slurry. If the calcium ion outside the cell is deficient (i.e. when the calcium is deficient), the magnesium ion inside the cell will permeate outside the cell, which can promote the cell aging and accelerate the human body aging.

The process is as follows: when the calcium ion in the blood plasma is deficient (namely, calcium is deficient), the calcium is mobilized from the skeleton, and the reduction of the calcium in the skeleton can cause osteoporosis and is very easy to cause fracture; meanwhile, calcium entering plasma from bones can be stagnated in blood vessel walls, and arterial walls can be damaged, so that lipids such as cholesterol and the like can easily permeate, arteriosclerosis is generated, and various diseases are caused.

The chalk, the ophicalcitum, the calcite, the gallstone and the oyster can increase the concentration of calcium ions in blood, prevent magnesium ions from exuding from cells, prevent cell aging, delay aging, enable the calcium ions and the magnesium ions to achieve dynamic balance inside and outside the cells and maintain the health of human bodies.

Therefore, the chalk, the ophicalcitum, the calcite, the quintet and the oyster supplement calcium ions and magnesium ions required by human bodies and have very important effects on preventing and treating diseases and delaying senility. Chalk, ophicalcitum, calcite, penta-lith and oyster can increase the concentration of calcium ions in blood to strengthen bones and teeth, and magnesium ions can strengthen bones and teeth and maintain bone growth. The chalk, ophicalcitum, calcite, penta-litha and oyster can increase calcium ion concentration in blood, densify blood vessel wall, prevent blood plasma exudation and promote blood coagulation, and can be used for stopping bleeding.

The magnesium ions in the product can activate the activity of multiple enzymes, participate in the reaction of more than 300 enzymes, and can dilate coronary artery to increase myocardial blood volume; the magnesium ions can relax muscles, improve sleep quality, relieve muscle tension and muscle spasm, reduce fatigue, and enhance intestinal wall peristalsis to promote body waste to be discharged out of the body, thereby keeping health.

Second, calculating and determining the required quantity

The third national nutrition survey shows that: 70-80% of people have insufficient calcium intake, and the calcium and magnesium supplement of human bodies is very important, but the calcium and the magnesium cannot exceed the standard and the standard exceeding causes certain harm to human bodies.

According to the Chinese Nutrition society recommendation:

the daily intake of calcium element for Chinese adults is 800mg (same as WHO), and Ca (40.08g/mol) is 800mg, converted into CaCO₃(100.08g/mol) was 1962.35 mg.

The third national nutrition survey result shows that the calcium intake of Chinese people is generally low, and the average daily calcium intake of each person is lower than 400 mg/(person-day) (calculated as 400 mg/(person-day)) Ca 400 mg/(person-day) is converted into CaCO₃The concentration was 981.18 mg/(homo day).

Each person needs to supplement CaCO every day₃CaCO as total required₃Amount 1962.35 mg-CaCO taken daily₃981.18mg＝981.17mg。

That is, each person needs to supplement 981.17mg CaCO every day₃For safety and reliability, 1000mg of CaCO is adopted₃/(person day). So as to ensure that enough calcium ions in extracellular slurry prevent magnesium ions in cells from exuding from the cells, prevent the cells from aging and further delay aging.

Finally, the value is determined: firstly, the medicine is safe and first, and the advantages and the disadvantages are improved and avoided as much as possible according to different medicine properties, the senna leaf is 500 mg/(people day), the aloe vera is 500 mg/(people day), the ophicalcite is 200 mg/(people day), the chalk is 100 mg/(people day), the calcite is 300 mg/(people day), the oyster is 300 mg/(people day), the five-color stone fat is 100 mg/(people day), and in sum, the pure traditional Chinese medicine preparation is 2000 mg/(people day), the dosage is adult dosage, and the dosage is reduced as much as possible for children.

Thirdly, suitable for people

The medicine is suitable for 80 percent of people who are in a calcium deficiency state.

Four, usage and dosage

2.0g of the product is taken after meals (the daily dosage for adults is reduced as appropriate for children), and the product is taken with warm water.

Five, attention and attention points and the contraindications

1. Constipation and dyspepsia are easily caused by taking the traditional Chinese medicine for a long time (see oyster on page 1362 of Chinese medicine dictionary).

2. The medication is placed in a location that is not easily accessible to the child.

3. It can impair the five internal organs and make people thin after long-term administration (see Chalk on page 68 of Bie Lu and Ben Cao gang mu).

4. It should be used with cautions for non-excessive heat (see calcite on page 599 of the Chinese medicine dictionary).

5. It should be used with cautions for people with allergic constitution.

6. The patient with lithiasis needs to consult with doctor.

7. It is contraindicated for patients with deficiency-cold of spleen and stomach and pregnant women (see Aloe on page 1297 of Chinese medicine dictionary).

8. The blood calcium and the blood magnesium are detected once a month, and the administration is stopped immediately when the blood calcium and the blood magnesium exceed the standard.

9. It is contraindicated for pregnant women and women without stasis (see Ophicalcitum chapter on page 1281 of Chinese medicinal dictionary and Ben Cao Jing Shu in Ben).

10. It should be used with cautions for children under two years old.

11. The dosage for the elderly needs to be increased from 1.5 g/day to 2.0 g/day, but not more than 2.0 g/day.

12. It is contraindicated in the period of pregnancy and lactation due to asthenia (see the Cassia angustifolia on page 2921 of the Chinese medicinal dictionary).

13. For renal insufficiency, it is forbidden (see "Chinese herbal medicine Zanbao" in Ophicalcitum).

14. Excessive dosage can cause abdominal pain, nausea and vomiting (see the folium sennae on page 2921 of the Chinese herbal dictionary).

15. For diarrhea due to middle cold, it is taken from decoction piece Xinshen which means the theory of senna leaf (see the section of decoction piece Xinshen on page 2921 of Chinese herbal medicine dictionary).

16. It is contraindicated for taking because its properties are changed.

Sixthly, pharmacological toxicity

1. Chalk

Compendium of materia Medica: nature and taste: bitter taste, warm nature and no toxicity. Enter lung and kidney meridians.

The bibliography: it can hurt five zang organs and make people thin after long-term taking.

2. Calcite

Chinese medicine big dictionary: bitter, pungent and cold.

The bibliography: bitter and pungent taste, cold and non-toxic.

"newly revised materia Medica: is cold in nature.

Article Hui Jing Yao (essence of article): the air is thin. Thick taste and yang within yin.

The book Ben Cao Jing Ji Zhu: croton tiglium.

3. Ophicalcitum

Contraindications are as follows: it is contraindicated for pregnant women who have no stasis and are prohibited to take it, as in Zangbao (Chinese herbal medicine). It should be forbidden for stomach disease patients and used with cautions for allergy patients.

Toxicity: LD for intravenous injection of Ophicalcitum decoction into mice₅₀LD of calcined Ophicalcitum decoction of 4.22g/kg for intravenous injection₅₀It was 21.5 g/kg. (& ltChinese medicine major dictionary & gt)

Ben Cao Jing Shu (the book of materia Medica Prime and Dredging): it should not be taken orally for patients without stasis. It is contraindicated for hematemesis due to fire and bleeding because of internal injury, blood coagulation and chest pain.

For recklessly blood movement due to internal fire, it is forbidden in Deg-Fu Ben Cao.

The herbal Zhenzhen: ophicalcitum belongs to the genus of plutonics, which should be rescued and supplemented with Du Shen Tang after bleeding is stopped, it is obtained as . If the patient is taken over, the muscle blood will be damaged, so that the patient must not care for it.

New materia Medica: greatly damaging yang blood.

4. Oyster shell

Medicine property: salty, neutral and slightly cold, enter liver and kidney meridians.

The book Jing: salty and mild in taste.

The bibliography: it is slightly cold and non-toxic.

The book materia Medica is as follows: slightly salty, slightly astringent and flat.

Ben Cao Jing Shu (the book of materia Medica Prime and Dredging): enter foot shaoyin, jueyin and shaoyang meridians.

Three-family notes of materia medica (leaf notes): the lung meridian of Taiyin, the bladder meridian of foot taiyang, and the kidney meridian of foot shaoyin.

5. Senna leaf

Nature and taste: sweet, bitter and cool, enter large intestine meridian. (& ltChinese medicine major dictionary & gt)

Modern practical traditional Chinese medicine: sweet, bitter and cold.

South China sea "Chinese herbal medicine word": enter the large intestine meridian.

It is contraindicated: it is contraindicated for pregnant women, women in menstrual period and lactation period. Decoction piece New references: it is contraindicated for middle cold diarrhea.

6. Aloe vera

Chinese pharmacopoeia: the property and taste effects are as follows: bitter and cold, purgative and purgative.

The Chinese medicine dictionary: bitter and cold in flavor enters large intestine meridian.

The book of Kaibao Ben Cao: bitter, cold and non-toxic.

Compendium (compendium): jueyin meridian herbs also.

Lei Gong processing pharmacology explanation: enter heart and liver meridians.

Ben Cao Jing Shu (the book of materia Medica Prime and Dredging): enter both the foot jueyin and taiyin meridians, and enter the hand shaoyin meridian.

The original menstrual period was: enter the liver meridian and pulse of jueyin.

The "Renzai of materia Medica": sweet and light taste, cold nature and no toxicity.

The Chinese herbal medicine word: enter liver, stomach and large intestine meridians.

7. Five-color stone grease

Compendium of materia Medica: odor: the five kinds of the stone fat are sweet, mild and nontoxic.

Shen nong Ben Cao Jing: bluestone, red stone, yellow stone, white stone, and black stone, etc. are sweet and neutral.

Seventhly, adverse reactions are not found.

Eighthly, storing the mixture in a cool and dry place.

Nine, effective period, 24 months.

Ten, pharmacokinetics

The powder has quick effect on treating leg cramps, and can take effect within 5 minutes after the powder is taken when the leg cramps, the leg cramps can be relieved or eliminated, the drug effect reaches the peak value within about 1 hour, the drug effect is gradually reduced, the drug effect is reduced to half within about 12 hours, the drug effect is reduced to almost zero within 24 hours, and the powder needs to be taken again. CaCO in the product₃And MgCO₃After being taken, the calcium chloride and the magnesium chloride are easy to deliquesce with gastric juice (main component HCl) to form calcium chloride and magnesium chloride, no calculus is formed in the body, the calcium chloride and the magnesium chloride are easy to absorb and utilize by the human body, the calcium chloride and the magnesium chloride which are not absorbed can be discharged out of the body along with the excrement, no aggregation is caused in the body, and the calcium chloride and the magnesium chloride have relative safety.

Eleven, execution standard: ICS 11.120C 05T/CACM 1220-2019.

Twelve, drug interactions

1. In the stomach, when gastric juice (mainly HCl) and edible acid such as oxalic acid coexist, the affinity of calcium magnesium and hydrochloric acid is far greater than that of calcium magnesium and oxalic acid (weak acid), calcium oxalate crystals are generally not generated, and the safety is relatively high.

2. Calcium antagonizes magnesium, and intravenous injection of 10% calcium gluconate or 10% calcium chloride generally alleviates symptoms in patients with hypermagnesemia.

3. The application of chalk, ophicalcitum, calcite, ichthammol and Concha Ostreae can induce constipation, and folium sennae and old Aloe have cathartic effect to increase water content in large intestine and stimulate secretion of mucus to exert cathartic effect to relieve constipation.

4. Magnesium ions in Ophicalcitum can enhance intestinal peristalsis, promote defecation, and relieve dry stool.

5. The chalk can hurt five internal organs after long-term use and cause emaciation, and can be used for comprehensively conditioning the five internal organs by matching with the five-color creosote to supplement the five internal organs along with the five-color creosote.

Compared with the prior art, the invention has the following beneficial effects:

the chalk, the ophicalcitum, the calcite, the quintocarpium, the oyster, the senna leaf and the old aloe are mutually cooperated, calcium ions and magnesium ions are formed in the stomach after the chalk, the ophicalcitum, the calcite, the senna leaf and the old aloe are taken, the calcium ions and the magnesium ions are easily absorbed and utilized, and the aims of strengthening the body and keeping healthy and delaying senility are achieved by supplementing the calcium ions and the magnesium ions.

Detailed Description

The present invention will be further described with reference to the following examples.

Example 1

The pure Chinese medicinal preparation for strengthening body and delaying aging is prepared from chalk, ophicalcitum, calcite, halloysite, oyster, senna leaf and aloe vera.

The preparation method of the pure traditional Chinese medicine preparation capable of strengthening body and delaying senility is characterized by comprising the following steps: the method comprises the following steps:

(1) selecting chalk, ophicalcitum, calcite, pentachromatic lithangite and oyster raw materials respectively, removing impurities, drying in the air, mixing 100g of chalk, 200g of ophicalcitum, 300g of calcite, 300g of pentachromatic lithangite and 100g of oyster materials after metering respectively, and then crushing, drying, sterilizing and grinding to obtain mixed powder;

(2) selecting folium sennae, removing impurities, air drying, sterilizing with ozone, and grinding to obtain folium sennae powder;

(3) selecting old aloe, removing impurities, air drying, sterilizing with ozone, and grinding to obtain old aloe powder;

(4) mixing 1000g of the prepared mixed powder, 500g of senna powder and 500g of old aloe powder, homogenizing and qualifying to prepare the pure Chinese medicinal preparation which can strengthen the body and delay senility.

Typical case

A certain Wang, male, 84 years old, has serious calcium deficiency and frequent cramps on legs, 2.0g of the pure Chinese medicinal preparation prepared by the invention is taken with warm boiled water 1 time a day, the situation is obviously improved after the administration, the cramping times are greatly reduced, the spirit and the appearance are better, and the body is better and unobstructed.

After taking the preparation for nearly two years, the blood calcium of a certain king is checked, and the checking result is shown in table 1.

Code	Name of item	Results	Unit of	Reference value
					Ca	Calcium carbonate	2.45	mmol/L	2.2-2.97
P	Inorganic phosphorus	1.26	mmol/L	0.9-1.97
					Mg	Magnesium alloy	0.92	mmol/L	0.7-1.2

TABLE 1

From the examination results of the blood calcium, it can be seen that the blood calcium value of a certain king is within the normal range, and the physical condition is good; meanwhile, the osteoporosis symptom before taking the preparation is greatly improved by carrying out bone density examination.

Of course, the foregoing is only a preferred embodiment of the invention and should not be taken as limiting the scope of the embodiments of the invention. The present invention is not limited to the above examples, and equivalent changes and modifications made by those skilled in the art within the spirit and scope of the present invention should be construed as being included in the scope of the present invention.

Claims

1. A pure traditional Chinese medicine preparation capable of strengthening body and delaying senility is characterized in that: the composition comprises an A component and a B component, wherein the A component is selected from at least one of chalk, calcite, penta-color petrolatum or oyster, and the B component is selected from at least one of senna leaf or aged aloe.

2. The pure herbal formulation of claim 1, which is capable of strengthening the body and delaying aging, wherein: the mass ratio of the component A to the component B is 1: 1.

3. The pure herbal formulation of claim 1, which is capable of strengthening the body and delaying aging, wherein: the component A also comprises ophicalcitum.

4. The pure herbal formulation of claim 3, which is capable of strengthening the body and delaying aging, wherein: comprises chalk, ophicalcitum, calcite, halloysite, oyster, senna leaf, and aloe vera.

5. The pure herbal formulation of claim 4, which is capable of strengthening the body and delaying aging, wherein: the mass ratio of the chalk, the ophicalcitum, the calcite, the marbled, the oyster, the senna leaf and the old aloe is 1:2:3:3:1:5: 5.

6. A method for preparing the pure Chinese herbal preparation for strengthening the body and delaying aging according to any one of claims 1 to 5, which is characterized in that: the method comprises the following steps:

7. The method for preparing a pure herbal formulation for strengthening the body and delaying aging as claimed in claim 6, wherein the pure herbal formulation comprises: the drying and sterilizing temperature in the step (1) is 350-450 ℃, and the particle size of the mixed powder A is less than 800 meshes.

8. The method for preparing a pure herbal formulation for strengthening the body and delaying aging as claimed in claim 6, wherein the pure herbal formulation comprises: the grain diameter of the mixed powder B in the step (2) is less than 800 meshes.

9. The method for preparing a pure herbal formulation for strengthening the body and delaying aging as claimed in claim 6, wherein the pure herbal formulation comprises: the preparation in the step (3) is any pharmaceutically acceptable preparation.

10. The method for preparing a pure herbal formulation for strengthening the body and delaying aging as claimed in claim 6, wherein the pure herbal formulation comprises: the preparation in the step (3) is in the form of powder, pills, tablets or capsules.