CN112057400A - Antiperspirant and preparation method thereof - Google Patents

Abstract

The invention discloses an antiperspirant and a preparation method thereof, wherein the antiperspirant is prepared from the following preparation raw materials in parts by weight: 5-25 parts of a humectant, 1-12 parts of a preservative, 1-7 parts of a thickener, 0.5-1.5 parts of a pH regulator, 5-1.5 parts of a honeysuckle flower extract, 10-80 parts of ethanol, 20-60 parts of zinc phenolsulfonate, 20-40 parts of an aloe barbadensis leaf extract, 4-15 parts of sodium lactate, 5-20 parts of a sophora flavescens extract, 2-5 parts of asiaticoside and 2-5 parts of a agave stem extract. By adopting the preparation raw materials and the synergistic effect of the preparation raw materials, the antiperspirant lotion has obvious antiperspirant and deodorant effects, is safe and non-irritant, can reduce sweat excretion, does not cause melanin formation, can improve skin quality and skin color, and keeps skin dry and healthy.

Description

Antiperspirant and preparation method thereof

Technical Field

The invention relates to the technical field of daily chemical products, in particular to an antiperspirant and a preparation method thereof.

Background

Sweating is a natural phenomenon, and the human body takes away heat through sweating to achieve the function of regulating the body temperature. Sweat is essentially odorless and contains, in addition to water, proteins, lipids, fatty acids, cholesterol, salts containing iron, and the like. Bacteria such as staphylococcus epidermidis and staphylococcus aureus decompose sweat, and ammonia, propionic acid, isovaleric acid, benzothiazole and the like may be generated, so that sour taste and odor are generated. In addition, urea discharged from sweat may have odor, and is particularly serious after decomposition. Eating high protein, high fat foods may result in increased odor. The cleaning is considered at ordinary times, and the odor can be reduced by regularly replacing clothes and bathing. To avoid the problem of hyperhidrosis, or to reduce body odor, some have chosen extreme methods, such as surgical removal of the apocrine gland or injection of botulinum bacteria. In fact, such extreme approaches are undesirable if not particularly serious. Reduce the amount of sweating, keep the daily fresh and dry, and can be realized by antiperspirant products. The antiperspirant product has the effect of reducing the amount of sweat that flows onto the skin surface and inhibiting the proliferation of body odor-causing bacteria, decomposing or adsorbing body odor-causing components. Common methods of body odor prevention and suppression are: 1) antiperspirant: inhibiting secretion of sweat glands; 2) and (3) bactericide: inhibiting the proliferation of bacteria on the skin surface; 3) adsorbent: converting original odorous substances into odorless substances through a chemical deodorant or an odor adsorbent; 4) aromatic agent: fragrance masking, and odor masking with pleasant-smelling essence.

Most antiperspirant products on the market are composed of chemical antiperspirant components, have certain irritation, and are easy to cause dermatitis, allergy and the like after being used by people with allergic constitution; in addition, sweat can be mixed with sebum on the body surface to form a milky lipid membrane, which has the effects of moistening and protecting the skin, and sweat glands are blocked for a long time to easily blacken the armpits in order to inhibit the sweat; more seriously, the skin is liable to produce a series of inflammations such as skin itch, red swelling, etc. because the biological metabolism in the skin is not normally excreted. In addition, most of the antiperspirant and deodorant products on the market lack the antiperspirant and waterproof properties, and under the condition of high temperature or after sports, the antiperspirant effect is difficult to maintain for a long time, and peculiar smell brought by sweat can also appear, so that the antiperspirant and deodorant effects are greatly reduced, and the inconvenience of consumers is caused.

Disclosure of Invention

The present invention is directed to solving at least one of the problems of the prior art. Therefore, the invention provides an antiperspirant and a preparation method thereof.

The technical scheme adopted by the invention is as follows:

the invention provides an antiperspirant lotion which is prepared from the following preparation raw materials in parts by weight: 5-25 parts of a humectant, 1-12 parts of a preservative, 1-7 parts of a thickener, 0.5-1.5 parts of a pH regulator, 5-1.5 parts of a honeysuckle flower extract, 10-80 parts of ethanol, 20-60 parts of zinc phenolsulfonate, 20-40 parts of an aloe leaf extract, 4-15 parts of sodium lactate, 5-20 parts of a sophora flavescens extract, 2-5 parts of asiaticoside and 2-5 parts of an agave stem extract.

According to some embodiments of the invention, the humectant is selected from at least one of betaine, polyol, natural moisturizing factor; preferably, the polyhydric alcohol is at least one selected from the group consisting of 1, 2-hexanediol, butanediol, glycerol, pentanediol, and octanediol. Wherein, the polyhydric alcohols such as 1, 2-hexanediol and the like have certain moisture retention performance and antibacterial performance.

According to some embodiments of the invention, the preservative is selected from at least one of methylparaben, phenoxyethanol/ethylhexyl glycerol, chlorphenesin, and p-hydroxyacetophenone. Because the pH value of the antiperspirant is generally 3.5-5, a preservative with bacteriostatic effect in the range needs to be selected.

According to some embodiments of the invention, the thickener is selected from at least one of hydroxyethylcellulose, xanthan gum, carrageenan, gum arabic, guar gum. The addition of the thickening agent can make the antiperspirant have certain consistency, so that the antiperspirant is beneficial to the use of consumers, and the liquid preparation is prevented from flowing to other positions after being smeared.

According to some embodiments of the invention, the pH adjusting agent is selected from at least one of lactic acid, citric acid, sorbic acid, DL-malic acid. The lactic acid has certain bacteriostatic and preservative capabilities while being used as a pH regulator, and the L-lactic acid is one of natural moisturizing factors and has the effect of moisturizing the skin.

According to some embodiments of the invention, the raw materials for preparation further comprise 0.1-0.5 parts of essence.

According to some embodiments of the invention, the raw materials for preparation further comprise 1-5 parts of a solubilizer; preferably, the solubilizer is selected from at least one of hydrogenated castor oil, coco-polyether-7, tween 20, dipropylene glycol. Hydrogenated castor oil is particularly compatibilized for fragrances.

According to some embodiments of the invention, the raw materials for preparation further comprise 0.1-0.9 parts of a cooling agent; preferably, the cooling agent is selected from at least one of menthol, borneol and camphor. The cooling agent can provide a cooling feeling for a user, and further can relieve skin itch and pruritic skin diseases caused by various reasons to a certain extent.

According to some embodiments of the invention, the antiperspirant solution has a pH value of 3.5-5.

In a second aspect of the invention, there is provided a process for preparing any of the antiperspirant lotions provided in the first aspect of the invention, comprising the steps of:

s1, mixing the humectant, the preservative and the thickener with water, stirring and heating to 85-90 ℃, and keeping the temperature for 10-30 min; homogenizing for 3-5 min, and stirring for 15-25 min under heat preservation;

s2, cooling the material obtained in the step S1 to 55-60 ℃, adding the agave stem extract, and keeping the temperature and stirring for 15-25 min;

s3, cooling the material obtained in the step S2 to 40-50 ℃, adding the rest of the preparation raw materials, and uniformly stirring.

The preparation method is simple to operate, has low requirements on reaction conditions in the production process, and is suitable for most production equipment on the market.

The embodiment of the invention has the beneficial effects that:

the embodiment of the invention provides an antiperspirant, which adopts zinc phenolsulfonate to be matched with a honeysuckle flower extract, an aloe barbadensis leaf extract, a sophora flavescens extract and a agave stem extract, and is matched with auxiliary components such as a humectant, a preservative, a pH regulator and the like, and the antiperspirant effect of the antiperspirant can be improved through the synergistic effect of the raw materials, and simultaneously, the irritation can be reduced, so that the mild, natural and efficient effects are achieved. Wherein the zinc phenolsulfonate has deodorant, antiperspirant and astringent effects. The aloe vera leaf extract contains aloe tincture which has strong antibacterial property and can kill fungi, mould, bacteria, viruses and other germs and inhibit and eliminate the breeding and propagation of pathogens; the aloe also has deodorant effect, and can prevent body odor of foot, mouth, and axilla; it also has skin caring, astringent, softening, moisturizing, antiinflammatory, and soothing effects. The sophora flavescens extract is rich in various alkaloids such as matrine and oxymatrine, can kill parasites, relieve itching, sterilize and relieve itching, has good relieving effect on skin pruritus, can balance grease secretion, dredge and astringe pores, clear away endotoxin impurities in skin, has rich herbal nutrition, promotes the growth and repair of damaged vascular nerve cells, recovers the activity of subcutaneous capillary cells, ensures that the skin is refined, accelerates wound healing, and has the effects of beautifying and protecting the skin. Asiaticoside has effects of promoting peripheral capillary regeneration, improving microcirculation, and accelerating wound healing, and can be used for treating trauma, burn, keloid and scleroderma, and preventing pigmentation. The Agave stem extract has effect in inhibiting free histamine, and can be used as allergy inhibitor to effectively reduce allergy. The flos Lonicerae extract contains various plant active ingredients effective for human body, and its main antibacterial component is organic acid compound, such as chlorogenic acid, luteolin, etc. flavonoids, and has antibacterial and immunity enhancing effects. In addition, the skin can be prevented from being dried due to the use of the antiperspirant lotion by adding the humectant; the addition of the ethanol is beneficial to forming film drying by the antiperspirant, keeps the skin dry and has a certain sterilization effect; sodium lactate is a natural component of human skin and hair, and is effective in treating skin disorders such as extreme dryness caused by xerosis cutis, and also has antimicrobial effect. Through the synergistic effect of the preparation raw materials, the antiperspirant lotion has obvious antiperspirant and deodorant effects, is safe and non-irritant, is suitable for soft and sensitive underarm skin cells, can effectively astringe the skin, effectively reduce sweat excretion, does not cause melanin formation, can improve the skin quality and skin color, and keeps the skin dry and healthy.

Drawings

FIG. 1 is the results of sensory evaluation of subjects using the antiperspirant of example 3;

figure 2 is the results of a sweat resistance durability test performed on subjects using the antiperspirant dew of example 3.

Detailed Description

The concept and technical effects of the present invention will be clearly and completely described below in conjunction with the embodiments to fully understand the objects, features and effects of the present invention. It is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all embodiments, and those skilled in the art can obtain other embodiments without inventive effort based on the embodiments of the present invention, and all embodiments are within the protection scope of the present invention.

Preparation of antiperspirant lotion

The antiperspirant lotion is prepared according to the following steps:

s1, preparing and taking materials according to the preparation raw material configuration of the antiperspirant in each embodiment in the table 1;

s2, uniformly stirring and mixing the PEG-40 hydrogenated castor oil and the essence to obtain a mixed solution A for later use; dispersing zinc phenolsulfonate in 10% pure water to obtain a transparent mixed solution B for later use; dispersing menthol in ethanol, stirring and dissolving to obtain a mixture C for later use;

s3, sequentially adding the rest purified water, betaine, methyl hydroxybenzoate and hydroxyethyl cellulose into a cold water pot, starting to heat, stirring and heating to 85-90 ℃, and keeping the temperature for 20 min; starting vacuum, homogenizing at high speed for 3min, and stirring for 20 min;

s4, cooling the material obtained in the step S3 to 60 ℃, adding the agave stem extract, and keeping the temperature and stirring for 20 min;

s5, continuously cooling the material obtained in the step S4 to 45 ℃, adding the prepared mixed solution A, the mixed solution B, the mixed solution C, 1, 2-hexanediol, the aloe vera leaf extract of the colanic element, lactic acid, sodium lactate, the radix sophorae flavescentis extract, the honeysuckle extract and phenoxyethanol/ethylhexyl glycerin, and stirring at the stirring speed of 50-60 rmp for 30 min.

TABLE 1 preparation of antiperspirant in each example

The traditional Chinese medicine and the traditional Chinese medicine extract adopted in the above embodiments are directly purchased from the market, and the specific sources thereof are shown in the following table 2.

TABLE 2 specific sources of some of the feedstocks

Comparative example 1

An antiperspirant solution, the comparative antiperspirant solution being substantially the same as that of example 3 except that: this comparative example antiperspirant solution was prepared without the sophora flavescens extract, and other preparation materials, amounts and preparation methods were the same as those of example 3.

Comparative example 2

An antiperspirant solution, the comparative antiperspirant solution being substantially the same as that of example 3 except that: this comparative example antiperspirant solution was prepared without aloe vera leaf extract, and the other preparation materials, amounts and preparation methods were the same as in example 3.

Comparative example 3

An antiperspirant solution, the comparative antiperspirant solution being substantially the same as that of example 3 except that: this comparative example antiperspirant solution was prepared without asiaticoside in the starting materials, and the other starting materials, amounts and preparation methods were the same as those of example 3.

Comparative example 4

An antiperspirant solution, the comparative antiperspirant solution being substantially the same as that of example 3 except that: this comparative example antiperspirant cream was prepared without the agave stem extract and was prepared using the same starting materials, amounts and methods as in example 3.

Comparative example 5

An antiperspirant solution, the comparative antiperspirant solution being substantially the same as that of example 3 except that: this comparative example antiperspirant solution was prepared without the honeysuckle extract, and the other preparation materials, amounts and preparation methods were the same as those of example 3.

(II) Performance testing

1. Testing the antiperspirant effect:

the degree of reduction in sweat secretion of the antiperspirant dew was determined by gravimetric method for each of the examples and comparative examples: specifically, 30 volunteers are selected as subjects, half of each volunteer is used for male and female, and the male and female volunteers are uniformly shaken before the antiperspirant is used, then the antiperspirant is uniformly smeared under the armpit and gently massaged until the antiperspirant is completely absorbed; 30 volunteers tested the antiperspirant in each example and comparative example in turn to serve as an experimental group, specifically after one antiperspirant sample is tested, the coated antiperspirant sample is washed off, and the antiperspirant effect test of the next antiperspirant sample is carried out under the same condition state; in addition, a set of tests of uncoated antiperspirant lotion was performed as a blank control.

Evaluation environment: the test experiment is carried out in the environment with the temperature (37.8 +/-1.1) DEG C and the relative humidity of 35-40 percent.

The method comprises the following specific operations: placing a fiber pad as an absorption pad at the armpit part of a subject to absorb sweat, obtaining the sweat amount absorbed by the absorption pad after lasting for 80min, and then calculating the sweat discharge reduction rate of the subject before and after using the antiperspirant dew through the following calculation formula, thereby analyzing the effect of the antiperspirant dew on reducing sweat secretion.

The formula for the amount of sweating and the rate of decrease in the amount of sweating is:

the axillary sweating amount is the weight of the absorption pad after the sweat collection and the weight of the absorption pad before the sweat collection;

the sweating rate is (control axillary sweating amount-experimental axillary sweating amount)/control axillary sweating amount.

The antiperspirant preparations of the examples and comparative examples were tested for reduction in perspiration by the above test methods (results are averaged)

) The results are shown in Table 3.

TABLE 3 reduction rate of sweating

As can be seen from table 3 above, the antiperspirant prepared in examples 1 to 3 has the synergistic effect of antiperspirant by adding five traditional Chinese medicines, namely the sophora flavescens extract, the asiaticoside, the honeysuckle flower extract, the agave extract and the aloe barbadensis leaf extract, and the traditional Chinese medicines and the traditional Chinese medicine extract, wherein the antiperspirant prepared in example 3 has the best effect, and the reduction rate of the perspiration amount can reach 29.68%.

2. Test of deodorizing Effect

The test method comprises the following steps: 30 axillary odor volunteers were selected as subjects, and were indiscriminately listed as test subjects regardless of the degree of odor, and the test subjects were continuously tested for 8 days to test the deodorizing effect of the antiperspirant lotion of each example and comparative example. Before use, the antiperspirant lotion is shaken lightly and then is evenly coated on the armpit, and the antiperspirant lotion is massaged lightly until the antiperspirant lotion is completely absorbed.

Effect evaluation criteria:

obviously improve the following steps: the preparation can be maintained for more than 8-12 hours without side effect;

the effect is shown: the preparation is maintained for 4-8 hours without side effect;

the method has the following advantages: the smell is obviously weakened and maintained for 0-4 hours, and no side effect is caused;

and (4) invalidation: the odor does not disappear and the deodorizing effect is not achieved.

The deodorant effect of the antiperspirant lotions of the respective examples and comparative examples was tested by the above method, and the use effect was filled in by the subjects according to their own experiences, and the results are shown in table 4.

TABLE 4 underarm deodorant test results

Antiperspirant dew	Obviously improve	Show effect	Is effective	Invalidation	High efficiency
						Example 1	7	15	8	0	100％
Example 2	9	15	6	0	100％
						Example 3	11	14	5	0	100％
Comparative example 1	0	4	16	10	66.67％
						Comparative example 2	4	9	16	1	93.3％
Comparative example 3	7	8	14	1	93.3％
						Comparative example 4	5	7	15	3	90％
Comparative example 5	6	6	14	4	86.67％

As can be seen from table 4 above, the preparation raw materials of the antiperspirant in embodiments 1 to 3 are compounded by five traditional Chinese medicines and traditional Chinese medicine extracts, so that a synergistic effect can be achieved, and the antiperspirant has a significant bromhidrosis removing effect.

3. Human body patch test

The test method comprises the following steps: referring to the cosmetic skin disease diagnosis standard and treatment principle general rule (GB17149-1997), 30 human subjects over 18 years old are selected, and 15 human subjects are selected; then, selecting qualified spot test materials, respectively using the antiperspirant dew of each embodiment and comparative example to carry out experiments, putting the antiperspirant dew of the tested object into a spot tester, wherein the dosage is about 0.03mL, and no substance is put in a blank control group; applying the spot test substance with the test substance on the inner side of forearm of the subject, while the test substance is a blank control group and an experimental group, and applying the spot test substance on skin by pressing with palm for 24 h; the examinee is ordered to keep the spot patch dry within 24h, and avoid strenuous exercise, scratching or long-time light irradiation.

The skin adverse reaction grading criteria are shown in table 5:

TABLE 5 Spot test grading Standard for adverse skin reactions

The patch test was carried out by the above method, and the results are shown in table 6.

TABLE 6 Patch test results for antiperspirant lotions of each example and comparative example

Antiperspirant dew	——	Class I	Stage II	Class III	IV stage	Sensitization rate
							Example 1	30	0	0	0	0	0％
Example 2	30	0	0	0	0	0％
							Example 3	30	0	0	0	0	0％
Comparative example 1	30	0	0	0	0	0％
							Comparative example 2	27	3	0	0	0	10％
Comparative example 3	29	1	0	0	0	3.33％
							Comparative example 4	28	2	0	0	0	6.67％
Comparative example 5	30	0	0	0	0	0％

As can be seen from the above table 6, the preparation raw materials of the antiperspirant dew in the embodiments 1-3 are compounded by five traditional Chinese medicines and traditional Chinese medicine extracts, so that the antiperspirant dew is mild and non-irritant, can greatly reduce the allergy rate, and is safe and reliable. Wherein the Aloe barbadensis leaf extract, Agave stem extract, and asiaticoside have repairing effect, and can greatly reduce irritation and anaphylaxis rate of the product.

4. Skin pigmentation test

The test method comprises the following steps: 30 volunteers, half of men and women, were selected as subjects, and the subjects were allowed to continuously use the antiperspirant prepared in example 3, and used one-sidedly, and the degree of pigmentation of the underarm skin was observed after continuous use for 1 month, 2 months and 3 months, respectively, and recorded. Wherein the pigmentation degree classification criteria are shown in table 7:

TABLE 7 skin pigmentation grading Standard

The degree of skin pigmentation using the antiperspirant lotion of example 3 was tested using the above method and the results are shown in table 8.

TABLE 8 axillary pigmentation level statistics

Time of day	——	Class I	Stage II	Pigmentation Rate
					The first month	30	0	0	0％
Second month of February	30	0	0	0％
					The third month	30	0	0	0％

As can be seen from table 8 above, the antiperspirant in example 3 does not cause pigmentation to blacken the underarm, has a significant antiperspirant and deodorant effect, is mild, safe and non-irritating, can effectively astringe the skin, effectively reduce the excretion of sweat, does not cause the formation of melanin, improves the skin quality and skin color, and keeps the skin dry and healthy.

In addition, the above subjects were subjected to sensory evaluation simultaneously with skin pigmentation test. Specifically, the dryness and comfort of the skin before and after the antiperspirant lotion was used were scored, the filling score was 5 points, and the average value was obtained, and the obtained results are shown in fig. 1. As can be seen from FIG. 1, after the antiperspirant lotion of example 3 was used, the dryness and comfort of the underarm skin were significantly improved.

The sweat resistance durability of the antiperspirant lotion is tested, two scenes are simulated, the sweat resistance maintaining time of the antiperspirant lotion is taken as a judgment standard, the unit is hour (H), the average value is taken, and the obtained result is shown in figure 2. As is clear from FIG. 2, the antiperspirant body lotion of example 3 showed excellent antiperspirant effect, when the duration of normal office maintenance exceeded 8 hours and the duration of outdoor activity exceeded 5 hours.

Scene one: in summer, the general office workers normally work (indoor temperature is 28 +/-2 ℃), and after the test subjects start to work in the morning, the antiperspirant dew is coated on the armpits and then normal activities are carried out.

Scene two: the subject was allowed to exercise outdoors (outdoor temperature 36. + -. 2 ℃ C.) and then applied with the antiperspirant to the underarm before exercising outdoors, followed by normal activities.

Claims (10)

1. The antiperspirant is characterized by being prepared from the following preparation raw materials in parts by weight: 5-25 parts of a humectant, 1-12 parts of a preservative, 1-7 parts of a thickener, 0.5-1.5 parts of a pH regulator, 5-1.5 parts of a honeysuckle flower extract, 10-80 parts of ethanol, 20-60 parts of zinc phenolsulfonate, 20-40 parts of an aloe leaf extract, 4-15 parts of sodium lactate, 5-20 parts of a sophora flavescens extract, 2-5 parts of asiaticoside and 2-5 parts of an agave stem extract.

2. The antiperspirant lotion of claim 1, wherein the humectant is selected from at least one of betaine, polyol, natural moisturizing factor; preferably, the polyhydric alcohol is at least one selected from the group consisting of 1, 2-hexanediol, butanediol, glycerol, pentanediol, and octanediol.

3. The antiperspirant lotion of claim 1, wherein the preservative is selected from at least one of methylparaben, phenoxyethanol/ethylhexyl glycerol, chlorphenesin, and p-hydroxyacetophenone.

4. The antiperspirant lotion of claim 1, wherein the thickener is selected from at least one of hydroxyethylcellulose, xanthan gum, carrageenan, gum arabic, and guar gum.

5. The antiperspirant lotion of claim 1, wherein the pH regulator is selected from at least one of lactic acid, citric acid, sorbic acid, and DL-malic acid.

6. The antiperspirant according to any one of claims 1 to 5, wherein the preparation raw material further comprises 0.1-0.5 part of essence.

7. The antiperspirant solution of claim 6, wherein the preparation raw material further comprises 1-5 parts of a solubilizer; preferably, the solubilizer is selected from at least one of hydrogenated castor oil, coco-polyether-7, tween 20, dipropylene glycol.

8. The antiperspirant lotion of any one of claims 1 to 5, wherein the preparation raw material further comprises 0.1-0.9 parts of a cooling agent; preferably, the cooling agent is selected from at least one of menthol, borneol and camphor.

9. The antiperspirant solution of any one of claims 1 to 5, wherein the pH value of the antiperspirant solution is 3.5-5.

10. A process for the preparation of an antiperspirant lotion according to any of claims 1 to 9, characterised by the steps of:

s1, mixing the humectant, the preservative and the thickener with water, stirring and heating to 85-90 ℃, and keeping the temperature for 10-30 min; homogenizing for 3-5 min, and stirring for 15-25 min under heat preservation;

s2, cooling the material obtained in the step S1 to 55-60 ℃, adding the agave stem extract, and keeping the temperature and stirring for 15-25 min;

s3, cooling the material obtained in the step S2 to 40-50 ℃, adding the rest of the preparation raw materials, and uniformly stirring.

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