CN111973874A - Photoelectric combined stimulation device and method - Google Patents

Abstract

The invention discloses an optoelectronic combined stimulation device and method. For patients with motor function loss or partial loss caused by spinal cord injury, a multi-sensor fusion optoelectronic combined stimulation method is adopted, and multi-channel electrodes are used to simultaneously collect different movement states of the brain and spinal cord. motion intent signal. Compare and explore the differences between EEG and spinal cord signals under different motion states. Through signal fusion and preprocessing, high signal-to-noise ratio and precise acquisition without motion intention signals are realized, and finally converted into high-precision command signals, and the sub-threshold value is used. Neural selectivity of electrical and optical stimulation to achieve targeted stimulation activation of target nerves.

Description

A kind of photoelectric combined stimulation device and method

technical field

The invention relates to the technical field of medical equipment, and more particularly to a photoelectric combined stimulation device and method.

Background technique

Spinal cord injury is a common and serious disabling disease, which can directly cause the patient's motor, sensory and sphincter dysfunction, seriously affect the patient's life, and even lead to death in severe cases. Spinal cord injury not only brings catastrophic consequences to the patient, but also brings a heavy burden to the family, society and even the country. Among them, the loss of motor function caused by spinal cord injury will seriously affect the patient's life, resulting in the inability to take care of themselves, seriously affecting the patient's mental health, and even life.

At present, spinal cord injury repair and functional remodeling technologies mainly include surgical treatment, drug therapy, stem cell transplantation, etc. However, due to the complex clinical situation of spinal cord injury, the repair and functional remodeling effects are not ideal. In recent years, the functional repair technology of spinal cord electrical stimulation based on brain/nerve interface technology has become a research hotspot in the field of spinal cord injury repair at home and abroad. However, the simple electrical stimulation technology has the following shortcomings: 1) The signal-to-noise ratio of the existing neural interface technology is low when the signal is extracted, and the motion intention signal cannot be accurately collected. Causes the issuance of stimulus orders to be unclear. 2) The motion intention signal extracted by the central nervous system cannot distinguish the motion state such as the size and speed of the action, which is not conducive to issuing precise command signals. 3) Due to the flow of current in the body, the stimulation location can only be one area, resulting in very low selectivity of nerve stimulation, which cannot target and stimulate the target nerve.

Therefore, how to issue command signals with high precision and activate target nerves through targeted stimulation to achieve spinal cord injury repair is an urgent problem for those skilled in the art.

SUMMARY OF THE INVENTION

In view of this, the present invention provides an optoelectronic combined stimulation device and method. For patients with loss or partial loss of motor function caused by spinal cord injury, a multi-sensor fusion optoelectronic combined stimulation method is used, and multi-channel electrodes are used to simultaneously collect the brain and brain cells. Motor intent signals in different motor states of the spinal cord. Compare and explore the differences between EEG and spinal cord signals under different motion states. Through signal fusion and preprocessing, high signal-to-noise ratio and precise acquisition without motion intention signals are realized, and finally converted into high-precision command signals, and the sub-threshold value is used. Neural selectivity of electrical and optical stimulation to achieve targeted stimulation activation of target nerves.

In order to achieve the above object, the present invention adopts the following technical solutions:

An optoelectronic combined stimulation device, comprising an EEG electrode module, a processor integrated device, a pulse generator, an optoelectronic combined stimulation electrode and a power supply; the EEG electrode module is wirelessly connected to the processor integrated device; the processor integrated device A lead is connected to the pulse generator; the pulse generator is connected to the optoelectronic combined stimulation electrode through a lead and a coupling optical fiber; the power source is connected to the EEG electrode module and the processor integrated device.

Preferably, the EEG electrode module includes a brain electrode, a conditioning and amplifying circuit, an antenna, and a wireless power supply module connected in sequence; the conditioning and amplifying circuit and the antenna are connected to the wireless power supply module, and the wireless power supply module is wirelessly connected The power supply is wirelessly powered by the power supply; the brain electrodes collect EEG signals.

Preferably, the processor integrated device includes an integrated spinal cord electrode module, a processor, a signal receiving device, an electrical stimulation programmer and the wireless power supply module; the spinal cord electrode module includes a spinal cord electrode and a conditioning and amplifying circuit, and the The spinal cord electrode collects spinal cord electrical signals and is electrically connected to the conditioning and amplifying circuit, and the spinal cord electrical signals are transmitted to the processor through the conditioning and amplifying circuit; the wireless power supply module of the processor integrated device is connected to the signal a receiving device, the processor and the electrical stimulation programmer; the power supply is wirelessly connected to the wireless power supply module of the processor integrated device to realize wireless power supply; the signal receiving device is connected to the electrical stimulation programmer the processor; the electrical stimulation programmer is connected to the pulse generator; the signal receiving device is wirelessly connected to the antenna.

Preferably, the processor is provided with a serial port and a Bluetooth module, and communicates with the host computer through the serial port or the Bluetooth module. The parameters of the processor in the processor integrated device can be set by the host computer, and the adjustment of the photoelectric combined stimulation device can be realized.

Preferably, the optoelectronic combined stimulation electrode adopts a subthreshold electrical stimulation method; the optoelectronic combined stimulation electrode is used for targeted stimulation of spinal cord motor nerves.

Preferably, the optoelectronic combined stimulation electrode adopts a multi-channel array electrode, adopts a flexible polymer material as a substrate, and distributes and attaches several channel electrode contacts on the substrate; the electrode contacts are composed of optical fiber contacts and electrode sheets, Each of the electrode pads corresponds to a different area of the spinal cord; each of the electrode contacts has a channel, each of the channels has a coupling optical fiber and a wire, each of the coupling optical fibers is correspondingly connected to one of the optical fiber contacts, and each One of the wires is correspondingly connected to one of the electrode sheets, and all the coupling optical fibers and the wires are aggregated to one end of the multi-channel array electrode and are derived from the bus.

Preferably, the conditioning and amplifying circuit receives the electrical signal, and the processing of the electrical signal includes sequentially performing pre-amplification, high/low pass filtering, 50 Hz notch, post-processing and level boosting.

A photoelectric combined stimulation method, comprising the following specific steps:

Step 1: The EEG signal and the spinal cord signal are simultaneously collected by the EEG electrode module and the spinal cord electrode module and sent to the processor;

Step 2: After the processor receives the signal, feature identification is performed on the signal, and feature differences are identified through algorithm comparison;

Step 3: Determine the motion intention from the characteristic signal identified by the comparison, encode the motion intention, and convert it into a stimulus command signal;

Step 4: transmitting the stimulation command signal to the pulse generator;

Step 5: The received stimulation command signal is converted into a specific stimulation signal by the pulse generator, and sent to the photoelectric combined stimulation electrode through the wire and the coupling optical fiber, and the target nerve tissue is targeted for stimulation to achieve coordinated movement .

It can be seen from the above technical solutions that, compared with the prior art, the present invention discloses a photoelectric combined stimulation device and method, which synchronously collects brain electrical signals and spinal cord electrical signals through brain electrodes and spinal cord electrodes, and transmits them to a processor for exercise. Intent feature recognition, according to the obtained movement intention portable stimulation control command, the stimulation signal is sent to the photoelectric combination stimulation electrode through the pulse generator. Target nerve, achieve high-precision activation of nerves, combine electrical stimulation with light stimulation, and place electrical stimulation in a sub-threshold state. At this time, light stimulation is added to illuminate the target nerve. Through the addition of the two energies, the target nerve can be stimulated highly selectively. The generation of action potentials without affecting other unrelated nerves ensures both safe and precise stimulation.

Description of drawings

In order to explain the embodiments of the present invention or the technical solutions in the prior art more clearly, the following briefly introduces the accompanying drawings that need to be used in the description of the embodiments or the prior art. Obviously, the accompanying drawings in the following description are only It is an embodiment of the present invention. For those of ordinary skill in the art, other drawings can also be obtained according to the provided drawings without creative work.

Fig. 1 accompanying drawing is the structure schematic diagram of the photoelectric combined stimulation device provided by the present invention;

Fig. 2 accompanying drawing is a schematic diagram of the structure of the photoelectric combined stimulation electrode provided by the present invention;

FIG. 3 is a schematic diagram of the structure of the electrode contact provided by the present invention.

Detailed ways

The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only a part of the embodiments of the present invention, but not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative efforts shall fall within the protection scope of the present invention.

The embodiment of the present invention discloses an optoelectronic combined stimulation device, comprising an EEG electrode module, a processor integrated device, a pulse generator, an optoelectronic combined stimulation electrode and a power supply; the EEG electrode module is wirelessly connected to the processor integrated device; the processor integrated device The lead is connected to the pulse generator; the pulse generator is connected to the photoelectric combined stimulation electrode through the lead and the coupling optical fiber; the power source is connected to the electroencephalogram electrode module and the processor integrated device.

In order to further optimize the above technical solutions, the EEG electrode module includes brain electrodes, conditioning and amplification circuits and antennae connected in sequence, and a wireless power supply module; the conditioning and amplification circuit and the antenna are connected to the wireless power supply module, and the wireless power supply module is wirelessly connected to the power supply, and the external power supply is carried out through the power supply. Wireless power supply; brain electrodes collect EEG signals.

In order to further optimize the above technical solution, the brain electrodes are integrated with a power supply module to supply power to the brain electrodes.

In order to further optimize the above technical solution, the processor integrated device includes an integrated spinal cord electrode module, a processor, a signal receiving device, an electrical stimulation programmer and a wireless power supply module; the spinal cord electrode module includes a spinal cord electrode and a conditioning amplifier circuit, and the spinal cord electrode collects the spinal cord The electrical signal is electrically connected to the conditioning and amplifying circuit, and the spinal cord electrical signal is transmitted to the processor through the conditioning and amplifying circuit; the wireless power supply module of the processor integrated device is connected to the signal receiving device, the processor and the electrical stimulation programmer; the power supply is wirelessly connected to the processor integrated device The wireless power supply module realizes wireless power supply; the signal receiving device and the electrical stimulation programmer are connected to the processor; the electrical stimulation programmer is connected to the pulse generator; the signal receiving device is wirelessly connected to the antenna.

In order to further optimize the above technical solution, the wireless power supply module and the power supply are used for wireless power supply, and the electromagnetic induction technology is used, and the electromagnetic induction coil is used to convert the electric energy into magnetic energy for wireless transmission and reception.

In order to further optimize the above technical solution, the processor is provided with a serial port and a bluetooth module, and communicates with the host computer through the serial port or the bluetooth module.

In order to further optimize the above technical scheme, the photoelectric combination stimulation electrode adopts the method of subthreshold electrical stimulation; the photoelectric combination stimulation electrode is used for targeted stimulation of the spinal cord motor nerve.

In order to further optimize the above technical solution, the optoelectronic combined stimulation electrode adopts a multi-channel array electrode, and a flexible polymer material is used as the substrate 1, and several channel electrode contacts 2 are distributed and attached on the substrate 1; Sheets 22 are formed, and each electrode sheet 22 corresponds to a different area of the spinal cord; each electrode contact 2 has a channel, each channel has a coupling optical fiber and a wire, each coupling optical fiber is correspondingly connected to an optical fiber contact 21, and each wire corresponds to An electrode sheet 22 is connected, and all the coupled fibers and wires are aggregated to one end of the multi-channel array electrode, which is derived from the bus 3 . The stimulation command signal sent by the electrical stimulation programmer is converted into a stimulation pulse signal by the pulse generator, which can trigger different coupling fibers and wires, so as to stimulate the nerves in different regions through the fiber contacts and electrode pads in different regions. When the human body moves, each movement corresponds to the activation of a group of nerves, and these nerves correspond to different positions of the spinal cord. As long as the type of movement can be identified, the corresponding position to be activated will be obtained, and the corresponding position can be activated to achieve a certain position. a movement.

In order to further optimize the above technical solution, the conditioning amplifier circuit receives the electrical signal, and the processing of the electrical signal includes sequentially performing pre-amplification, high/low pass filtering, 50HZ notch, post-processing and level boosting.

A photoelectric combined stimulation method, comprising the following specific steps:

S1: The EEG signal and the spinal cord signal are simultaneously collected by the EEG electrode module and the spinal cord electrode module and sent to the processor;

S2: After the processor receives the signal, it performs feature recognition on the signal, and identifies the feature difference through algorithm comparison;

S3: Determine the motion intention from the characteristic signal identified by the comparison, encode the motion intention, and convert it into a stimulus command signal;

S4: transmit the stimulation command signal to the pulse generator;

S5: The received stimulation command signal is converted into a specific stimulation signal by the pulse generator, and is sent to the photoelectric combined stimulation electrode through the wire and the coupling optical fiber, and the target nerve tissue is stimulated to achieve coordinated movement.

Example

(1) The sciatic nerve isolated from the lumbar enlargement part of the spinal cord extends to the muscles of the lower limbs. During the movement of the lower limbs, it controls the different muscles of the lower limbs by receiving motion signals from the brain and the spinal cord, and coordinately completes a certain action. Human walking can be divided into the following stages:

1) Single-leg stance leading limb forward stage:

Tighten the lower abdomen to keep the trunk stable, the iliopsoas contracts to flex the hips, the hamstrings and calves contract to flex the knees, and the tibialis anterior and peroneal muscles contract to cause ankle flexion (hooking action). The hip joint on the side is close, and the extensor muscles of the toes are contracted and the toes are hooked (toe extension);

2) The heel is in contact with the ground

Hip flexion is terminated, quadriceps flexion and knee extension are terminated, ankle flexion and toe extension are terminated;

3) The center of gravity is moved forward, and the single-leg support stage

The quadriceps are tightened, and the glutes begin to contract;

4) The center of gravity continues to move forward and tends to fall forward

The hips contract and extend the hips, maintain stability in other places, and the calf and foot muscles contract significantly;

5) Promotion stage:

The hips continue to tighten and extend the hips, the quadriceps continue to exert force to extend the knees, and the supporting limb on the side will be fully extended until the swing limb is about to hit the ground;

During the swing, the opposite shoulder will move closer to the hip joint of the swinging limb. At the end of this stage, the flexor digitorum longus exerts force, that is, the toes also need to exert force when walking;

6) When the swinging limb touches the ground, a new cycle begins.

The above is the process of muscle and coordinated contraction involved in the normal walking process of the human body. If a patient with spinal cord injury achieves the normal swing of the lower limbs, different muscles need to be activated at one time according to this process. This process needs to be designed to stimulate different areas of the spinal cord to target and control different muscles. , to coordinate the contraction and complete the swing of the lower limbs. The stimulation of different regions requires an algorithm to support the electrical discharge or light of each channel in the multi-channel electrode, stimulate the optimal region, and finally target and control the core muscle group to complete the lower limb swing.

(2) Stimulation by electrodes requires the following two actions:

1. Select different stimulation modes, different electrode pads in the electrodes correspond to different regions of the spinal cord, thereby stimulating different parts. In the process of exercise, different muscle tissues need to be closely coordinated, and algorithm support is required. First, the EEG and spinal cord signals are collected by electrodes, and the signal characteristic parameters are obtained through pattern recognition processing. Correlation analysis is used to obtain the interaction between central nervous cells. The spinal cord electrical signal and the EEG signal are fused with each other to realize the comprehensive feature fusion of "spinal cord + brain" signal, so as to obtain the motion intention. The electrical stimulation programmer writes the algorithm-supported stimulation code according to the motion intention, and executes the code to form a set of stimulation patterns. , and then the pulse generator will send the electric pulses generated by the specific different stimulation modes to the photoelectric combination stimulation electrodes, and finally complete the stimulation.

Different stimulation modes can be programmed into the electrical stimulation programmer in advance. By identifying different motion intentions, different stimulation modes can be called, reducing the difficulty of real-time programming and achieving a higher degree of realization. The specific motion pattern can be graded by the strength of the analyzed motion intention signal to realize the walking action. It can be divided into three different levels (slow, medium and fast), including the speed of the legs and the size of the swing. Corresponding to realize different motion states.

2. To analyze the motor intention signal, the collected EEG signal and spinal cord signal need feature recognition and processing, and the signal code is converted into a stimulus command signal.

(3) the installation mode of the device of the present invention is:

The brain electrodes are implanted into the cerebral cortex to collect EEG signals, and the spinal cord electrodes are implanted into the T7-T8 spinal cord epidural to collect spinal cord electrical signals. The spinal cord electrodes are integrated with the processor and integrated with a signal receiving device to receive brain electric signal. The EEG signal and the spinal cord signal are transmitted to the processor through the preprocessing of the conditioning and amplifying circuit, and the signal is characterized by the processor to identify different types of motor intention signals, and encode them into stimulation command signals. On the one hand, preprocessing reduces the processing difficulty and power consumption of the processor, and on the other hand, it can improve the processing speed. The pulse generator is connected with the multi-channel photoelectric combination stimulation electrode through a wire, and the photoelectric combination stimulation electrode is implanted into the epidural of the lumbar enlargement (L1-S2) for targeted stimulation of the spinal cord motor nerve. The processor integrated device is connected with the pulse generator through wires (that is, the electrical stimulation programmer wire is connected to the pulse generator, and the electrical stimulation programmer sends different stimulation modes to the pulse generator), and sends the stimulation command signal to the pulse generator. , the pulse generator generates stimulation pulse signals by coordinating the photoelectric stimulation mode, and sends the stimulation pulse signals to the photoelectric combination stimulation electrodes for targeted stimulation of nerves.

(4) Accurate collection of brain and spinal cord motor intention signals

Determine the position (point or area) of the motor signal in the spinal nerve, use multi-channel array electrodes that meet the requirements of the central nerve electrical signal acquisition, explore the accurate positioning of the electrode in the spinal nerve, improve the signal-to-noise ratio of the motor intention signal, and realize its electrophysiological signal accurate collection.

The multi-channel array electrode is shown in Figure 2, and the electrode sheet is shown in Figure 3. The multi-channel array electrode is made of flexible polymer materials (polydimethylsiloxane (PDMS), polyimide (PI), parylene Toluene (Parylene, etc.) is used as the substrate, and 16-channel electrode contacts are distributed and attached to the substrate. The contacts are composed of optical fiber contacts and electrode sheets, so that the electrodes can not only conduct electricity, but also guide light. Among the 16 channels, each channel has its own coupling optical fiber and wire, which is finally aggregated to one end of the electrode, and is derived from the bus. The diameter of the optical fiber is 1 mm, and the electrode sheet is 4 mm long and 1.5 mm wide.

(5) Recognition of motion intent features based on different motion states (brain and spinal cord)

Based on the extracted brain and spinal cord motion intention signals, different experimental strategies were used to identify the motion intention signals of patients in different motion states (movement speed, movement amplitude, etc.). The differences between the EEG signals and the spinal cord signals under different motion states are compared, and the spinal nerve signals and the EEG signals are fused and preprocessed to finally achieve accurate motion feature recognition without the use of motion states.

The process of motor intent feature recognition is as follows: for action A, first issue an action command to a normal person (experimenter), and after the experimenter receives the command, the brain will issue an action signal, which is transmitted to the target muscle group through the spinal cord. After the group receives the command signal, it starts to take corresponding actions. In this process, the brain releases certain electrophysiological signals while issuing instructions, and the electrical signals are received by the outside world in an overall fixed form. The general reflection of physiological activity on the surface of the cerebral cortex or scalp. By analyzing the EEG signal of a specific action, the wavelet transform or artificial neural network algorithm can be used to identify the EEG signal, and the specific action is matched with the characteristics of the EEG signal. , it can be indicated that the experimenter is going to perform action A. This whole process is also referred to as "motion intent signal acquisition and recognition" for a specific action.

(6) Motor function remodeling based on photoelectric combined stimulation

Subthreshold electrical stimulation is used to stimulate the target area, and by applying near-infrared light, the target nerve is precisely selected to stimulate the nerve to achieve high-precision activation of the nerve. When the nervous system is stimulated with current or voltage, when the stimulation signal reaches a certain value, the nervous system can be induced to generate an action potential, and the action potential can be transmitted to the target muscle, causing the target muscle to contract. This specific value , also known as stimulus threshold. When the stimulation signal is close to but lower than the stimulation threshold, no action potential can be generated at this time. If a certain amount of light stimulation is added to the stimulated nerve in this state, the receptor nerve can reach the stimulation threshold through the addition of the two energies. An action potential is generated, causing the target muscle to contract.

If electrical stimulation is used alone, because the current can spread around the stimulation site, other nerves are easily excited by mistake, causing other muscles to contract, resulting in the inability to complete the action. Light stimulation is highly selective and only stimulates the directly irradiated part, but light stimulation alone is easily limited by the damage threshold and 2 times the stimulation threshold, which is prone to tissue damage. Therefore, electrical stimulation can be combined with optical stimulation, and the electrical stimulation is in a sub-threshold state. At this time, optical stimulation can be added to illuminate the target nerve. Through the addition of the two energies, the target nerve can be highly selectively stimulated to generate action potentials without affecting other energies. Incoherent nerves can not only ensure safe stimulation, but also stimulate accurate.

The various embodiments in this specification are described in a progressive manner, and each embodiment focuses on the differences from other embodiments, and the same and similar parts between the various embodiments can be referred to each other. As for the device disclosed in the embodiment, since it corresponds to the method disclosed in the embodiment, the description is relatively simple, and the relevant part can be referred to the description of the method.

The above description of the disclosed embodiments enables any person skilled in the art to make or use the present invention. Various modifications to these embodiments will be readily apparent to those skilled in the art, and the generic principles defined herein may be implemented in other embodiments without departing from the spirit or scope of the invention. Thus, the present invention is not intended to be limited to the embodiments shown herein, but is to be accorded the widest scope consistent with the principles and novel features disclosed herein.

Claims (8)

1. a photoelectric combination stimulation device, is characterized in that, comprises an EEG electrode module, a processor integrated device, a pulse generator, a photoelectric combination stimulation electrode and a power supply; The EEG electrode module is wirelessly connected to the processor integration device; The processor integrated device is connected to the pulse generator by wires; the pulse generator is connected to the optoelectronic combined stimulation electrode through wires and coupling optical fibers; the power source is connected to the EEG electrode module and the processor integrated device. 2. A kind of photoelectric combined stimulation device according to claim 1, is characterized in that, described electroencephalogram electrode module comprises the brain electrode that is connected in sequence, conditioning amplifying circuit and antenna, and wireless power supply module; Described conditioning amplifying circuit and The antenna is connected to the wireless power supply module, and the wireless power supply module is wirelessly connected to the power supply to realize wireless power supply; the brain electrodes collect EEG signals. 3. An optoelectronic combined stimulation device according to claim 2, wherein the processor integrated device comprises an integrated spinal cord electrode module, a processor, a signal receiving device, an electrical stimulation programmer and the wireless power supply module; the spinal cord electrode module includes a spinal cord electrode and a conditioning amplifying circuit, the spinal cord electrode collects spinal cord electrical signals, and is electrically connected to the conditioning amplifying circuit, and the spinal cord electrical signal is transmitted to the processor through the conditioning and amplifying circuit ; the wireless power supply module of the processor integrated device is connected to the signal receiving device, the processor and the electrical stimulation programmer; the power supply is wirelessly connected to the wireless power supply module of the processor integrated device, Wireless power supply is realized; the signal receiving device and the electrical stimulation programmer are connected to the processor; the electrical stimulation programmer is connected to the pulse generator; the signal receiving device is wirelessly connected to the antenna. 4 . The photoelectric combined stimulation device according to claim 3 , wherein the processor is provided with a serial port and a bluetooth module, and communicates with the host computer through the serial port or the bluetooth module. 5 . 5 . The optoelectronic combined stimulation device according to claim 1 , wherein the optoelectronic combined stimulation electrode adopts a subthreshold electrical stimulation method; and the optoelectronic combined stimulation electrode is used for targeted stimulation of spinal cord motor nerves. 6 . 6. A kind of photoelectric combination stimulation device according to claim 1, is characterized in that, described photoelectric combination stimulation electrode adopts multi-channel array electrode, adopts flexible polymer material as substrate, and distributes and attaches several channel electrodes on described substrate Contacts; the electrode contacts are composed of optical fiber contacts and electrode sheets, each of which corresponds to a different area of the spinal cord; each of the electrode contacts has a channel, and each of the channels has a coupling optical fiber and a wire , each of the coupling fibers is connected to one of the fiber contacts, each of the wires is connected to one of the electrode sheets, and all the coupled fibers and the wires are aggregated to one end of the multi-channel array electrode by the bus export. 7. A photoelectric combined stimulation device according to claim 2 or 3, wherein the conditioning and amplifying circuit receives electrical signals, and the processing of the electrical signals comprises sequentially performing pre-amplification, high/low pass filtering, 50 Hz Notch, post method and level boost. 8. a photoelectric combined stimulation method according to claim 1-7 is characterized in that, comprises the following concrete steps: Step 1: The EEG signal and the spinal cord signal are simultaneously collected by the EEG electrode module and the spinal cord electrode module and sent to the processor; Step 2: After the processor receives the signal, feature identification is performed on the signal, and feature differences are identified through algorithm comparison; Step 3: Determine the motion intention from the characteristic signal identified by the comparison, encode the motion intention, and convert it into a stimulus command signal; Step 4: transmitting the stimulation command signal to the pulse generator; Step 5: The received stimulation command signal is converted into a specific stimulation signal by the pulse generator, and sent to the photoelectric combined stimulation electrode through the wire and the coupling optical fiber, and the target nerve tissue is targeted for stimulation to achieve coordinated movement .

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