CN111840763A - Liquid conveying device and treatment device - Google Patents

Abstract

The invention relates to a liquid delivery device and a treatment device. The liquid delivery device comprises a casing with an inner cavity, the casing is provided with a delivery port communicating with the inner cavity, and the delivery port is used to communicate with an external mechanism; A first chamber for storing liquid dispersant and a second chamber for storing dispersoid are formed in the middle, and the second chamber is communicated with the delivery port; the first valve controls the on-off between the first chamber and the second chamber; The first sealing part controls the on-off between the delivery port and the external mechanism; the pressure applying mechanism. When the first valve is opened and the first blocking part blocks the delivery port, the first chamber and the second chamber are connected, so that the liquid dispersant enters the second chamber and mixes with the dispersoid to form a dispersion system; After the delivery port is blocked by the blocking portion, the pressure applying mechanism applies pressure, and the dispersion system in the second chamber flows to and from the external mechanism. The liquid conveying device can complete the configuration and conveying of the dispersion system in sequence, so as to avoid contamination of the dispersion system.

Description

A liquid delivery device and treatment device

technical field

The invention relates to the technical field of medical devices, in particular to a liquid delivery device and a treatment device.

Background technique

Since the 1970s, interventional medical devices have been widely used in the treatment of various cardiovascular diseases, and have experienced simple balloon dilatation (PTCA), bare metal stents (BMS) and drug-eluting stents (DES). ) three milestone stages of rapid development. At present, DES is the first choice for the treatment of obstructive coronary heart disease, but it has problems such as late stent thrombosis, long vascular healing time, and easy influence on vascular arteries. In-stent stenosis (ISR), small vessel disease and bifurcation disease also Limits the application of DES. Under this circumstance, drug-coated balloon (DCB) came into being and showed better therapeutic effect.

Most of the drug balloons in the prior art coat the surface of the balloon with anti-proliferative drugs. When in use, the balloon is first pushed to the lesion, and then the balloon is expanded to release the drug. The drug balloon of this design has the following defects: (1) During the process of pushing the balloon, the drug is easy to fall off and lose, resulting in insufficient drug dose, and even the fallen drug may cause toxic and side effects; (2) The surface of the drug balloon is coated with The covered drug is likely to form large drug particles during expansion, which is likely to cause distal vascular embolism and has a high safety risk; (3) the drug dose is uncontrollable, and one balloon can only be used for one site.

In view of the above-mentioned defects, a drug perfusion balloon is currently available on the market, that is, a liquid drug is injected into the balloon, and then the liquid drug flows out of the micropores on the balloon wall and is absorbed by the diseased tissue. Although the perfusion drug balloon solves some of the defects of the drug-coated balloon, the perfusion drug balloon still has the problem that the process of transferring the medicine to the balloon after preparation is cumbersome and difficult to control, and the medicine is easily contaminated during preparation and transfer of the medicine.

SUMMARY OF THE INVENTION

The purpose of the present invention is to provide a liquid delivery device and a treatment device. The liquid delivery device can directly transfer the medicament into the balloon after completing the medicament configuration, which simplifies the process of medicament transfer, and does not require additional intermediate containers to avoid contamination. Pharmacy.

In order to achieve the above object, the present invention provides a liquid delivery device, comprising:

a casing with an inner cavity, the casing is provided with a delivery port communicating with the inner cavity, and the delivery port is used to communicate with an external mechanism; a first chamber and a first chamber are formed in the inner cavity of the casing a second chamber, the first chamber is used to store the liquid dispersant, the second chamber is used to store the dispersant, and the second chamber is communicated with the delivery port;

a first valve for controlling the on-off between the first chamber and the second chamber;

a first blocking part for controlling the on-off between the delivery port and the external mechanism; and,

pressure applying mechanism;

The liquid delivery device is configured such that when the first valve is opened and the delivery port is blocked by the first blocking portion, the first chamber and the second chamber are communicated, so that the a liquid dispersant enters the second chamber and mixes with the dispersoid to form a dispersion;

The liquid delivery device is further configured such that the pressure applying mechanism applies pressure to allow the dispersion system in the second chamber to pass through the delivery port after the first blocking portion is released from blocking the delivery port. The delivery port flows to the external mechanism.

Optionally, the pressure applying mechanism is provided in the first chamber, and is configured to open the first valve after applying pressure to a first predetermined value.

Optionally, the first valve is a one-way valve configured to open after being subjected to a first predetermined value of pressure directed from the first chamber to the second chamber, and is It remains closed when subjected to pressure directed from the second chamber to the first chamber.

Optionally, the first valve includes a valve seat, a first sealing plate and a first elastic member, the valve seat is arranged on a dividing mechanism, and the dividing mechanism is used to divide the inner cavity into the first a chamber and the second chamber; and the valve seat is provided with an axially through fluid channel, and the wall of the fluid channel is provided with a stepped surface; the first elastic member is arranged on the fluid channel inside, one end of the first elastic member is connected with the wall of the fluid channel, and the other end is connected with the first sealing plate;

The first sealing plate abuts against the step surface under the action of the first elastic member to close the fluid channel; the first sealing plate is directed from the first chamber to the second When the pressure of the chamber is at the first predetermined value, the first elastic member is deformed so that the first sealing plate is separated from the step surface and the fluid channel is opened.

Optionally, the pressure applying mechanism includes a first piston, and the first piston is configured to move toward the second chamber under the action of an external force, so that the first valve is opened.

Optionally, a dividing mechanism is further included for dividing the inner cavity into the first chamber and the second chamber, and the first valve is arranged on the dividing mechanism.

Optionally, the dividing mechanism includes a second piston;

The pressure applying mechanism is used for applying pressure to the second piston to drive the second piston to move and apply pressure to the dispersion system.

Optionally, a second blocking part is further included, which is arranged at the delivery port and is used to block the delivery port when the pressure value received by the dispersion system exceeds a second predetermined value.

Optionally, the second blocking portion includes a second sealing plate and a second elastic member, one end of the second elastic member is connected to the second sealing plate, and the other end is connected to the housing;

The second piston applies pressure to the dispersion system, and further applies pressure to the second sealing plate, and the second blocking portion is configured to, when the pressure received by the second sealing plate is less than or equal to the first sealing plate. When there are two predetermined values, the second elastic member supports the second sealing plate, so as to keep the second sealing plate away from the conveying port and keep the conveying port open; when the pressure of the second sealing plate When the value is greater than the second predetermined value, the second elastic member is deformed to move the second sealing plate toward the delivery port, so as to block the delivery port.

Optionally, the pressure applying mechanism further includes a push rod disposed at one end of the first piston away from the dividing mechanism, for receiving external force and driving the first piston to move.

Optionally, the first blocking part includes a second valve, and the liquid delivery device further includes a pressure control mechanism;

The pressure control mechanism is configured to monitor the pressure to which the dispersion system is subjected, and to control the second valve to block the delivery port when the pressure to which the dispersion system is subjected exceeds a second predetermined value.

Optionally, a filter mechanism is also included, which is arranged at the delivery port.

Optionally, a luer connector is provided at the delivery port for detachable connection with the external mechanism.

In order to achieve the above object, the present invention also provides a treatment device, comprising:

A liquid delivery device as described in any preceding item;

a liquid dispersant, disposed in the first chamber;

a solid medicament, disposed in the second chamber;

A balloon catheter includes a catheter and a balloon, one end of the catheter is communicated with the balloon, the other end is used to communicate with the delivery port of the liquid delivery device, and the balloon is provided with a plurality of micropores.

Optionally, the distribution density of the micropores at the proximal end of the balloon is less than the distribution density of the micropores at the distal end of the balloon; and/or,

The diameter of the micropores provided at the proximal end of the balloon is smaller than the diameter of the micropores provided at the distal end of the balloon.

Optionally, the diameter of the micropores is 5um-50um.

Optionally, the dispersoid is dispersed in the liquid dispersant to form a suspension, and the particle size in the suspension is 30nm-500nm.

Compared with the prior art, the liquid delivery device and the treatment device of the present invention have the following advantages:

First, the aforementioned liquid conveying device includes: a casing with an inner cavity, the casing is provided with a conveying port communicating with the inner cavity, and the conveying port is used for communicating with an external mechanism; A first chamber and a second chamber are formed in the inner cavity, the first chamber is used to store the liquid dispersant, the second chamber is used to store the dispersoid, and the second chamber is connected with the delivery The first valve is used to control the connection between the first chamber and the second chamber; the first blocking part is used to control the connection between the delivery port and the external mechanism; And, the pressure applying mechanism. The liquid delivery device is configured such that when the first valve is opened and the delivery port is blocked by the first blocking portion, the first chamber and the second chamber are communicated, so that the A liquid dispersant enters the second chamber and mixes with the dispersoid to form a dispersion. The liquid delivery device is further configured such that the pressure applying mechanism applies pressure to allow the dispersion system in the second chamber to pass through the delivery port after the first blocking portion is released from blocking the delivery port. A delivery port flows to and from the external mechanism. That is to say, the configuration of the dispersion system and the transportation of the dispersion system can be completed in sequence in the liquid conveying device, without additionally introducing other containers, and avoiding the contamination of the dispersion system during the conveying process.

Description of drawings

The accompanying drawings are used for better understanding of the present invention and do not constitute an improper limitation of the present invention. in:

FIG. 1 is a schematic structural diagram of a liquid delivery device according to an embodiment of the present invention;

FIG. 2 is a schematic structural diagram of a treatment device according to an embodiment of the present invention;

3 is a schematic structural diagram of a first valve of a liquid delivery device according to an embodiment of the present invention, and the first valve in the illustration is a one-way valve;

4 is a schematic structural diagram of a liquid delivery device according to an embodiment of the present invention, and the first valve in the illustration is different from the first valve of the liquid delivery device shown in FIG. 1;

5 is a schematic structural diagram of a liquid delivery device according to another embodiment of the present invention;

6 is a schematic structural diagram of a liquid delivery device provided by the present invention according to still another embodiment, in which the second sealing plate of the second blocking portion does not block the delivery port;

7 is a schematic structural diagram of the second sealing plate of the second blocking portion in the liquid delivery device shown in FIG. 6 when the delivery port is blocked;

FIG. 8 is a partial structural schematic diagram of a balloon catheter of a treatment device according to an embodiment of the present invention.

[reference numerals are explained below]:

100 - liquid delivery device;

110 - shell;

111-delivery port, 112-first chamber, 113-second chamber;

120 - the second piston;

130 - the first valve;

131- valve seat, 132- first sealing plate, 133- first elastic piece, 134- fluid channel, 135- connecting rod, 136- sealing block;

140 - the first blocking part;

150 - pressure applying mechanism;

151 - first piston, 152 - push rod;

160 - filter mechanism;

170-Second blocking part;

171 - the second cover plate, 172 - the second elastic part;

200-balloon catheter;

210-balloon;

211 - Micropore;

220 - catheter;

300 - liquid dispersant;

400 - solid medicine;

500 - Liquid Elixir.

Detailed ways

The embodiments of the present invention are described below through specific specific examples, and those skilled in the art can easily understand other advantages and effects of the present invention from the contents disclosed in this specification. The present invention can also be implemented or applied through other different specific embodiments, and various details in this specification can also be modified or changed based on different viewpoints and applications without departing from the spirit of the present invention. It should be noted that the drawings provided in this embodiment are only to illustrate the basic concept of the present invention in a schematic way, so the drawings only show the components related to the present invention rather than the number, shape and the number of components in actual implementation. For dimension drawing, the type, quantity and proportion of each component can be changed at will in actual implementation, and the component layout may also be more complicated.

In addition, each embodiment of the following description has one or more technical features, but this does not mean that the person using the present invention must implement all the technical features in any embodiment at the same time, or can only implement different embodiments separately. One or all of the technical features of the . In other words, under the premise of possible implementation, those skilled in the art can selectively implement some or all of the technical features in any embodiment according to the disclosure of the present invention and depending on design specifications or implementation requirements, or The combination of some or all of the technical features in the multiple embodiments is selectively implemented, thereby increasing the flexibility of the implementation of the present invention.

As used in this specification, the singular forms "a," "an," and "the" include plural referents, and the plural forms "a plurality" include two or more referents unless the content clearly dictates otherwise. As used in this specification, the term "or" is generally employed in its sense including "and/or" unless the content clearly dictates otherwise, and the terms "installed", "connected", "connected" shall be To be understood in a broad sense, for example, it may be a fixed connection, a detachable connection, or an integral connection. It can be a mechanical connection or an electrical connection. It can be directly connected, or indirectly connected through an intermediate medium, and it can be the internal communication between two elements or the interaction relationship between the two elements. For those of ordinary skill in the art, the specific meanings of the above terms in the present invention can be understood according to specific situations. Also, herein, "proximal" and "distal" refer to the orientation, position of the various elements relative to each other from the perspective of the physician using the medical device, although "proximal" and "distal" are non-limiting , but usually "proximal" refers to the end that is closer to the doctor, and "distal" refers to the end that first enters the patient's body.

One of the objectives of the present invention is to provide a liquid delivery device, which includes a housing, a first valve, a first blocking part and a pressure applying mechanism. Wherein, the housing has an inner cavity, and the housing is provided with a delivery port communicating with the inner cavity, and the delivery port is used for communicating with an external mechanism. A first chamber and a second chamber are formed in the inner cavity of the housing, the first chamber is used to store the liquid dispersant, the second chamber is used to store the dispersant, and the second chamber is used to store the dispersant. A chamber communicates with the delivery port. The first valve is used to control the connection between the first chamber and the second chamber. The first blocking part is used to control the connection between the delivery port and the external mechanism. The liquid delivery device is configured such that when the first valve is opened and the delivery port is blocked by the first blocking portion, the first chamber and the second chamber are communicated, so that the A liquid dispersant enters the second chamber and mixes with the dispersoid to form a dispersion. The liquid delivery device is further configured such that the pressure applying mechanism applies pressure to allow the dispersion system in the second chamber to pass through the delivery port after the first blocking portion is released from blocking the delivery port. A delivery port flows to and from the external mechanism.

That is, the liquid dispersant is pre-stored in the first chamber of the liquid delivery device, the dispersoid is pre-stored in the second chamber, and the first chamber is opened under predetermined conditions when the dispersion system needs to be configured. The valve allows the liquid dispersant to flow into the second chamber and mix with the dispersoid to form a dispersion. The delivery port is then communicated with the external mechanism and pressurized by a pressure applying mechanism to force the dispersion to flow into the external mechanism and act on the target location. In other words, the configuration and delivery of the dispersion system can be completed at one time by using this device, and the whole process does not require additional containers or delivery structures to avoid introducing impurities into the dispersion system. In the medical field, the liquid dispersant can disperse a solid drug to form a liquid drug, and the liquid drug can be in a solution state, a suspension state, or an emulsion state. The dispersoid refers to a solid pharmaceutical that can be dispersed in the liquid dispersion to obtain a liquid pharmaceutical.

Another object of the present invention is to provide a treatment device, the treatment device includes the liquid delivery device, the liquid dispersion, the solid drug and the balloon catheter, and the liquid dispersion is stored in the first chamber , the solid medicament is stored in the second chamber, the balloon catheter includes a balloon and a catheter, the proximal end of the catheter is used to communicate with the delivery port, and the distal end of the balloon is connected to the The inside of the balloon is connected, and the balloon is also provided with micro-holes connecting the inside and the outside of the balloon. In the treatment device, the solid medicament is a pure drug or a pharmaceutical composition, and the solid medicament can be dispersed in the dispersant by the treatment device to form a liquid medicament, and the liquid medicament can be directly perfused to the balloon to avoid drug contamination.

In order to make the objects, advantages and features of the present invention clearer, the present invention will be further described in detail below with reference to the accompanying drawings. It should be noted that, the accompanying drawings are all in a very simplified form and in inaccurate scales, and are only used to facilitate and clearly assist the purpose of explaining the embodiments of the present invention. The same or similar reference numbers in the drawings represent the same or similar parts.

Fig. 1 shows a schematic structural diagram of a liquid delivery device provided by a preferred embodiment, and Fig. 2 shows a structural schematic diagram of a treatment device including the liquid delivery device.

Please refer to FIG. 1 and FIG. 2 , the liquid delivery device includes a casing 110 , a dividing mechanism, a first valve 130 , a first blocking part 140 and a pressure applying mechanism 150 ; the casing 110 has an inner cavity, the The housing 110 is provided with a delivery port 111 communicating with the inner cavity, and the delivery port 111 is used for communicating with a balloon catheter 200 (ie, the external mechanism). The dividing mechanism is arranged in the inner cavity, and divides the inner cavity into a first chamber 112 and a second chamber 113, the first chamber 112 is used to store the liquid dispersion 300, and the first chamber 112 is used for storing the liquid dispersion 300. The second chamber 113 is used for storing the solid medicine 400 (ie, the dispersoid), and the second chamber 113 communicates with the delivery port 111 . The first valve 130 is disposed on the dividing mechanism, and is used to control the connection between the first chamber 112 and the second chamber 113 . The first blocking part 140 is used to selectively block the delivery port 111 .

The liquid delivery device is configured such that when the first valve 130 is opened and the first blocking part 140 blocks the delivery port 111, the first chamber 112 and the second chamber 113 In communication, the liquid dispersant enters the second chamber 113 and mixes with the solid medicament 400 to form a liquid medicament 500 (ie, the dispersion system, as shown in FIG. 6 ). The liquid delivery device is further configured so that when the first blocking part 140 releases the blocking of the delivery port 111 and the delivery port 111 communicates with the balloon catheter 200 , the pressure applying mechanism Pressure is applied to cause the liquid medicament 500 in the second chamber 113 to flow to and from the balloon catheter 200 through the delivery port 111 to act on the target site.

The liquid delivery device 100 provided in this embodiment can be used to complete the configuration of the liquid medicine, and can be directly connected to the balloon catheter 200 without the aid of other instruments to deliver the liquid medicine 500 to the balloon catheter 200, the transfer process of the liquid medicine is simplified, and the contamination of the liquid medicine during the transfer process is also avoided. Those skilled in the art should know that the balloon catheter 200 includes a balloon 210 and a catheter 220, the proximal end of the catheter 200 is used to communicate with the delivery port 111, and the distal end of the catheter 200 is connected to the balloon 210 Connected. The balloon 210 is suitable for introduction into a patient's vasculature, such as coronary arteries, peripheral arteries, or elsewhere in the vasculature. A plurality of micro-holes 211 are provided through the wall of the balloon 210, and the plurality of micro-holes 211 are used for the liquid medicine 500 to flow out and act on the target position.

In this embodiment, the liquid dispersing agent 300 can be selected from any one of liquids capable of dissolving or dispersing solid medicines, such as purified water, physiological saline, and contrast agent, or a mixed liquid thereof. The solid medicament 400 may be a pure drug, or a pharmaceutical composition composed of a pure drug and other components, and the other components may be at least one of excipients, surfactants, stabilizers, and the like. Preferably, the solid drug 400 is a nano-drug particle composed of pure drug and other components, and the nano-drug particle includes micelles, liposomes, and the like. The solid medicament 400 may be in the form of powder, granules, flakes or coated on the cavity wall of the second chamber 113 in the form of a film coating, and the solid medicament 400 may also be loaded in a capsule shell. The present invention does not limit the type of the solid medicament 400, which is specifically selected according to actual needs. The solid medicament 400 can be an anti-proliferative drug, an anti-inflammatory drug, an anti-inflammatory drug, an anti-proliferative drug, an antibacterial drug, an anti-tumor drug, an anti-mitotic drug, a cytostatic drug, or a cytotoxic drug. , anti-osteoporosis drugs, anti-angiogenesis drugs, anti-stenosis drugs, microtubule-inhibiting drugs, anti-metastatic drugs, or anti-thrombotic drugs, etc. The solid medicament 400 includes but is not limited to the following drugs: dexamethasone, prednisolone, corticosterone, budesonide, estrogen, sulfasalazine, ammonia salicylic acid, acemetacin, aescin, amino acid Pterin, antimycotic, arsenic trioxide, aristolochic acid, aspirin, berberine, ginkgol, rapamycin and its derivatives (including zotarolimus, everolimus, biomus, 7- O-desmethylrapamycin, temsirolimus, defoslimus, etc.), endostatin, angiostatin, angiopeptin, monoclonal antibodies that block smooth muscle cell proliferation, levofloxacin, paclitaxel, docetaxel Paclitaxel, hydroxycamptothecin, vinblastine, vincristine, doxorubicin, 5-fluorouracil, cisplatin, thymidine kinase inhibitor antibiotics (especially actinomycin-D), hormones, antibody cancer drugs, At least one of bisphosphonates, selective estrogen receptor modulators, strontium ranelate, cyclosporine A, cyclosporine C, and brefeldin A.

Please continue to refer to FIG. 1 , in an exemplary embodiment, the pressure applying mechanism 150 is disposed in the first chamber 112 , and the liquid dispersant 300 is stored in the pressure applying mechanism 150 and the dividing between institutions. When the pressure applying mechanism 150 applies pressure to the liquid dispersant 300, and then applies pressure to the first valve 130 to a first predetermined value, the first valve 130 is opened. Specifically, the first valve 130 is preferably a one-way valve, and the one-way valve is configured to be subjected to a pressure of a first predetermined value directed from the first chamber 112 to the second chamber 113 open and remain closed under pressure directed from the second chamber 113 to the first chamber 112 . This arrangement ensures that the liquid dispersion 300 and the solid medicament 400 are mixed in the second chamber 113 to form the liquid medicament 500 . The structure of the one-way valve can be a conventional design in the prior art, such as a silicone sealing ring with a cutout, a baffle and the like.

The preferred structure of the first valve 130 can be seen in FIG. 3 , and the arrows in the diagram indicate the flow direction of the liquid dispersant 300 . As shown in FIG. 3 , the first valve 130 includes a valve seat 131 , a first sealing plate 132 and a first elastic member 133 . The shown dividing mechanism is provided with a through hole (not marked in the figure), and the valve seat 131 is disposed at the through hole and connected with the hole wall of the through hole. The valve seat 131 is provided with a fluid channel 134 for communicating the first chamber 112 and the second chamber 113 , and a wall of the fluid channel 134 is provided with a stepped surface. The first elastic member 133 is disposed in the fluid channel 134 , one end of which is connected to the wall of the fluid channel 134 , and the other end is connected to the first sealing plate 132 . The first sealing plate abuts against the step surface under the action of the first elastic member 133 to close the fluid channel; when the first sealing plate 132 is received from the first chamber 112 When the pressure is directed to the first predetermined value of the second chamber 113, the first elastic member 133 is deformed so that the first sealing plate 132 is separated from the stepped surface and the fluid channel 134 is opened to realize the The first chamber 112 communicates with the second chamber 113 . In this embodiment, the stepped surface faces the second chamber 113, and the first elastic member 133 is disposed close to the second chamber 113. When the first elastic member 133 is under pressure, the The first elastic member 133 is compressed so that the fluid channel 134 is opened. In an alternative embodiment, the first elastic member 133 may also be disposed close to the first chamber 112 , and at this time, the first elastic member 133 is stretched so that the fluid channel 134 is opened. The first elastic member 133 includes but is not limited to a spring, and the first predetermined value is determined according to the specific type and material of the first elastic member 133. For example, when the first elastic member 133 is a spring, the The first predetermined value is determined according to the spring coefficient of the spring. Optionally, the pressure applying mechanism 150 in this embodiment includes a first piston 151 , and the first piston 151 moves toward the liquid dispersant 300 under the action of an external force to apply pressure to the liquid dispersant 300 . The pressure applying mechanism 150 may further include a push rod 152, the push rod 152 is disposed at one end of the first piston 151 away from the dividing mechanism, for receiving the external force and driving the first piston 151 to move . That is, when the first valve 130 is opened, the pressure applying mechanism 150 and the first chamber 112 form a structure similar to a syringe, which is convenient for operation and easy to apply external force.

When the pressure applying mechanism 150 includes the first piston 151 , the structure of the first valve 130 may also be as shown in FIG. 4 . At this time, the first valve 130 includes a connecting rod 135 and a sealing block 136 , one end of the connecting rod 135 is connected with the first piston 151 , and the other end is connected with the sealing block 136 . The dividing mechanism has a through hole, and the sealing block 136 is disposed in the through hole. When the first piston 151 moves toward the dividing mechanism, the first piston 151 pushes the connecting rod 135 to move toward the second inner cavity 113 until the sealing block 136 is removed from the through hole, so that all The liquid dispersant 300 can flow into the second chamber 113 through the channel in the middle of the dividing mechanism. Further, the dividing mechanism is movable, and when the dividing mechanism is movable, the second piston 120 is included. The pressure applying mechanism 150 is also used for applying pressure to the second piston 120 and driving the second piston 120 to move toward the liquid medicine, so as to apply pressure to the liquid medicine 500 . In detail, after all the liquid dispersant 300 in the first chamber 112 enters the second chamber 113, the user applies an external force to the first piston 151, and the first piston 151 faces the The second piston 120 moves until the first piston 151 is in contact with the second piston 120; continues to apply external force to the first piston 151, the first piston 151 drives the second piston 120 toward the liquid medicine 500 moves to force the liquid medicine 500 to flow into the balloon catheter 200 from the delivery port 111, that is, the pressure applying mechanism 150, the second piston 120 and the housing 110 together form a structure similar to a syringe . Those skilled in the art can understand that, in this embodiment, the frictional force between the second piston 120 and the housing 110 may resist the first predetermined value applied by the pressure applying mechanism 150 to the first valve 130 . In order to prevent the second piston 120 from moving under the pressure of the first predetermined value, this can be achieved in practice by selecting the first elastic member 133 with a suitable elastic coefficient.

Optionally, the casing 111 is further provided with a scale line, and the scale line is used to display the amount of the liquid medicine 500 in the second chamber 113 and the position of the second piston 120, so as to facilitate judgment The total amount of the liquid medicine 500 delivered by the liquid delivery device 100 to the balloon catheter 200 .

In a further improvement of the present invention, as shown in FIG. 5 , the liquid delivery device 100 further includes a filter mechanism 160 , the filter mechanism 160 is, for example, a filter membrane, which is arranged at the delivery port 111 and is used for filtering the liquid The medicament is filtered to prevent particles with larger particle sizes in the liquid medicament 500 from being transported to the balloon catheter 200 and entering the vasculature to avoid embolism to the vasculature. Preferably, the pore size of the filter pores on the filter membrane may be 1 um (micrometer) to 10 um (micrometer), so as to allow particles with a particle size smaller than or equal to 10 um to enter the balloon catheter 200 .

Further, as shown in FIG. 6 and FIG. 7 , the liquid delivery device 100 further includes a second blocking part 170 , which is arranged at the delivery port 111 and is used for the pressure value of the liquid medicine 500 to exceed The delivery port 111 is closed at the second predetermined value. When the delivery pressure of the liquid medicine 500 is too high, the second blocking part 170 is used to block the delivery port 111 to suspend the delivery of the liquid medicine, so as to avoid damage to the vascular system caused by the high pressure.

In detail, the second blocking portion 170 includes a second sealing plate 171 and a second elastic member 172, one end of the second elastic member 172 is connected to the second sealing plate 171, and the other end is connected to the shell body 111 is connected. The pressure applying mechanism 170 applies pressure to the liquid medicine, and transmits the pressure to the second sealing plate 171 through the liquid medicine. When the pressure on the second sealing plate 171 is less than or equal to the second predetermined value, the second sealing plate 171 is away from the delivery port 111 to keep the delivery port 111 open (as shown in FIG. 6 ) ), and when the pressure on the second sealing plate 171 is greater than the second predetermined value, the second elastic member 172 is deformed and drives the second sealing plate 171 to move toward the delivery port 111 until The delivery port 111 is blocked (as shown in FIG. 6 ). When the user adjusts the pressure applying mechanism 150 so that the pressure on the liquid medicine 500 is less than or equal to the second predetermined value, the shape of the second elastic member 172 is restored, and the second seal is driven. The plate 171 is away from the delivery port 111, so that the delivery port 111 is reopened and the delivery of the liquid medicine is resumed. In this embodiment, the second elastic member 172 is disposed at one end of the second sealing plate 171 close to the delivery port 111 , so the second elastic member 172 is compressed and deformed to drive the second sealing plate 171 moves and blocks the delivery port 111 . The second elastic member 172 includes, but is not limited to, a spring, and the above purpose can be achieved by selecting a spring with an appropriate elastic coefficient.

In an alternative embodiment, the first blocking portion 140 includes a second valve, and the liquid delivery device further includes a pressure control mechanism configured to monitor the pressure experienced by the liquid medicament 500 , and when the pressure of the liquid medicine 500 is greater than the second predetermined value, the second valve is controlled to close to block the delivery port 111 .

In addition, in order to facilitate the connection between the liquid delivery device 100 and the balloon catheter 200, one of the delivery port 111 of the liquid delivery device 100 and the catheter 220 of the balloon catheter 200 is provided with a Luer male connector , the other features a female Luer connector.

Those skilled in the art can understand that the foregoing description of each component of the liquid delivery device is only a preferred structure realized by the liquid delivery device, which should not be construed as a limitation of the present invention. In other implementation manners, the first valve may be a solenoid valve, and the first valve may also be directly connected to the inner wall of the casing, and the inner cavity of the casing is divided into two parts by the first valve. In the first chamber and the second chamber, the dividing mechanism can be omitted at this time. The first valve is opened by energizing, and pressure is applied to the liquid medicine by passing insoluble gas into the second chamber, but when the liquid delivery device of this scheme delivers the liquid medicine, the The casing should always be kept in a vertical state, and the amount of liquid medicine to be prepared is more than the actual required amount, so as to prevent gas from entering the blood vessel.

Referring back to FIG. 2 , the treatment device provided by the embodiment of the present invention includes the aforementioned liquid delivery device 100 , liquid dispersion 300 , solid drug 400 , and balloon catheter 200 . Wherein, the liquid dispersant 300 and the solid medicament 400 can be reasonably selected with reference to the foregoing introduction, and will not be repeated here. The balloon catheter 200 includes a balloon 210 and a catheter 220 , the wall of the balloon 210 is provided with a plurality of micro-holes 211 , and the proximal end of the catheter 220 is used to communicate with the delivery port 111 of the liquid delivery device 100 . The communication, distal end is in communication with the balloon 210 . After the liquid dispersion 300 and the solid medicine 400 are mixed in the second chamber 113 of the liquid delivery device 100 to form a liquid medicine, they are directly delivered to the balloon catheter 200 from the delivery port 111 , and then Flow out from the micro-holes 211 on the balloon 210 to avoid contamination of the medicine.

After the liquid dispersant 300 and the solid medicine 400 are dispersed, a liquid medicine 500 in the form of a solution or suspension can be formed. The liquid medicine 500 is preferably in a stable suspension state, and the drug particles therein are nano-sized particles. Optionally, the particle size of the pharmaceutical agent in the suspension is 30nm-500nm, preferably 35nm-300nm.

After the liquid medicine 500 is delivered to the balloon 210 through the catheter 220, it flows out from the micro-hole 211 and acts on the target position. The micropores 211 may be uniform or non-uniform on the wall of the balloon 210, respectively. The inventor further found that when the micropores 211 are evenly distributed on the wall of the balloon 210, the flow rate and pressure of the liquid medicine 500 flowing out from the micropores 211 at different positions are inconsistent. The flow rate and pressure of the liquid medicament 500 flowing from the pores 211 at the proximal end of the balloon 210 are greater than the flow rate and pressure of the liquid medicament 500 flowing from the pores 211 at the distal end of the balloon 210 . In this way, the liquid medicine 500 flowing out from the proximal micro-hole 211 of the balloon 210 is likely to cause damage such as hematoma and endothelial shedding at the proximal end of the blood vessel (the position where the blood vessel is relative to the proximal end of the balloon), and easily causes Vascular spasm is extremely risky. In order to solve this problem, in this embodiment, the distribution density of the micropores 211 at the proximal end of the balloon 210 is preferably smaller than the distribution density of the micropores 211 at the distal end of the balloon 210 , and it is further preferred that the distribution density of the micropores 211 at the distal end of the balloon 210 is located in the balloon 210 . The diameter of the micropores 211 at the proximal end is smaller than the diameter of the micropores 211 at the distal end of the balloon 210 . In an exemplary embodiment, the diameter of the micropores 211 can be selected in the range of 5um-50um.

In this embodiment, the liquid medicine 500 is configured by the liquid delivery device 100 and the delivery of the liquid medicine 500 is completed. During delivery, the liquid medicine 500 can flow out from the micropores 211 of the balloon 210 at a pressure of 4 atmospheres (0.608mpa) to 16 atmospheres (1.62mpa). The user can also control the total amount of the liquid medicine 500 delivered to the balloon catheter 200 and the duration of administration by controlling the pressurizing speed and pressurizing time of the pressure applying mechanism 150 . In a typical embodiment, a total amount of 0.5ml-2ml of medicine needs to be used to the target position within 15s-60s. At this time, after the first piston 151 is in contact with the dividing mechanism, According to the size of the housing 111 , the moving speed of the dividing mechanism can be reasonably controlled, so that the dividing mechanism can move a predetermined distance within a predetermined time. Preferably, the liquid medicine is used up within 15s-30s.

According to the technical solution provided by the embodiment of the present invention, the liquid delivery device can directly deliver the liquid medicine to the balloon catheter and act on the target position after the configuration of the liquid medicine is completed, without using other instruments to transfer the liquid medicine to the target position. Transfer to avoid contamination of liquid agents. Further, when the pressure applying mechanism is used to complete the delivery of the liquid medicine, by setting a scale on the casing and adjusting the pressurization speed, the control of the usage amount and the duration of the liquid medicine is realized.

Although the present invention is disclosed above, it is not limited thereto. Various modifications and variations can be made in the present invention by those skilled in the art without departing from the spirit and scope of the invention. Thus, provided that these modifications and variations of the present invention fall within the scope of the present invention and its technical equivalents, the present invention is also intended to include such modifications and variations.

Claims (17)

1. A liquid delivery device, characterized in that, comprising: a casing with an inner cavity, the casing is provided with a delivery port communicating with the inner cavity, and the delivery port is used to communicate with an external mechanism; a first chamber and a first chamber are formed in the inner cavity of the casing a second chamber, the first chamber is used to store the liquid dispersant, the second chamber is used to store the dispersant, and the second chamber is communicated with the delivery port; a first valve for controlling the on-off between the first chamber and the second chamber; a first blocking part for controlling the on-off between the delivery port and the external mechanism; and, pressure applying mechanism; The liquid delivery device is configured such that when the first valve is opened and the delivery port is blocked by the first blocking portion, the first chamber and the second chamber are communicated, so that the a liquid dispersant enters the second chamber and mixes with the dispersoid to form a dispersion; The liquid delivery device is further configured such that the pressure applying mechanism applies pressure to allow the dispersion system in the second chamber to pass through the delivery port after the first blocking portion is released from blocking the delivery port. The delivery port flows to the external mechanism. 2 . The liquid delivery device of claim 1 , wherein the pressure applying mechanism is disposed in the first chamber and configured to apply pressure to a first predetermined value, causing the first The valve is open. 3. The fluid delivery device of claim 2, wherein the first valve is a one-way valve configured to be directed from the first chamber to the second chamber when subjected to The chamber opens after a first predetermined value of pressure and remains closed when subjected to a pressure directed from the second chamber to the first chamber. 4. The liquid delivery device according to claim 3, wherein the first valve comprises a valve seat, a first sealing plate and a first elastic member, the valve seat is provided on a dividing mechanism, and the dividing The mechanism is used to divide the inner cavity into the first cavity and the second cavity; and the valve seat is provided with an axially through fluid channel, and the wall of the fluid channel is provided with a stepped surface ; The first elastic member is arranged in the fluid channel, one end of the first elastic member is connected with the wall of the fluid channel, and the other end is connected with the first sealing plate; The first sealing plate abuts against the step surface under the action of the first elastic member to close the fluid channel; the first sealing plate is directed from the first chamber to the second When the pressure of the chamber is at the first predetermined value, the first elastic member is deformed so that the first sealing plate is separated from the step surface and the fluid channel is opened. 5. The liquid delivery device according to claim 2, wherein the pressure applying mechanism comprises a first piston, and the first piston is configured to move toward the second chamber under the action of an external force, so that the The first valve is opened. 6. The liquid delivery device according to claim 5, further comprising a dividing mechanism for dividing the inner cavity into the first chamber and the second chamber, the first valve provided on the dividing mechanism. 7. The liquid delivery device of claim 6, wherein the dividing mechanism comprises a second piston; The pressure applying mechanism is used for applying pressure to the second piston to drive the second piston to move and apply pressure to the dispersion system. 8 . The liquid delivery device according to claim 7 , further comprising a second blocking part, which is arranged at the delivery port and is used when the pressure value received by the dispersion system exceeds a second predetermined value. 9 . Block the delivery port. 9 . The liquid delivery device according to claim 8 , wherein the second blocking part comprises a second sealing plate and a second elastic member, and one end of the second elastic member is connected to the second sealing plate. 10 . connected, and the other end is connected with the shell; The second piston applies pressure to the dispersion system, and further applies pressure to the second sealing plate, and the second blocking portion is configured to, when the pressure received by the second sealing plate is less than or equal to the first sealing plate. When there are two predetermined values, the second elastic member supports the second sealing plate, so as to keep the second sealing plate away from the conveying port and keep the conveying port open; when the pressure of the second sealing plate When the value is greater than the second predetermined value, the second elastic member is deformed to move the second sealing plate toward the delivery port, so as to block the delivery port. 10 . The liquid delivery device according to claim 6 , wherein the pressure applying mechanism further comprises a push rod, which is arranged at one end of the first piston away from the dividing mechanism, and is used for receiving external force and driving the The first piston moves. 11. The liquid delivery device of claim 1, wherein the first blocking portion comprises a second valve, and the liquid delivery device further comprises a pressure control mechanism; The pressure control mechanism is configured to monitor the pressure to which the dispersion system is subjected, and to control the second valve to block the delivery port when the pressure to which the dispersion system is subjected exceeds a second predetermined value. 12 . The liquid delivery device according to claim 1 , further comprising a filter mechanism disposed at the delivery port. 13 . 13 . The liquid delivery device according to claim 1 , wherein a luer connector is provided at the delivery port for detachably connecting with the external mechanism. 14 . 14. A therapeutic device, comprising: The liquid delivery device of any one of claims 1-13; a liquid dispersant, disposed in the first chamber; a solid medicament, disposed in the second chamber; A balloon catheter includes a catheter and a balloon, one end of the catheter is communicated with the balloon, the other end is used to communicate with the delivery port of the liquid delivery device, and the balloon is provided with a plurality of micropores. 15. The treatment device of claim 14, wherein the distribution density of the micropores at the proximal end of the balloon is less than the distribution density of the micropores at the distal end of the balloon; and/ or, The diameter of the micropores provided at the proximal end of the balloon is smaller than the diameter of the micropores provided at the distal end of the balloon. 16. The treatment device according to claim 14, wherein the diameter of the micropores is 5um-50um. 17. The treatment device according to claim 14, wherein the solid medicament is dispersed in the liquid dispersion to form a suspension, and the particle size in the suspension is 30 nm-500 nm.

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