CN111840448B

CN111840448B - Preparation method and application of anti-chapping compound traditional Chinese medicine liposome

Info

Publication number: CN111840448B
Application number: CN202010674208.7A
Authority: CN
Inventors: 杨志喜; 陈勤发; 林艺青; 陈嘉玲; 杨彦; 李嘉琳; 李丹; 朱腾辉; 徐红; 郑猷天; 陈妍; 袁小娇; 李艳雯; 蔡红丽
Original assignee: Mingchen Health Co ltd
Current assignee: Guangdong Mingchen Daily Chemical Co ltd
Priority date: 2020-07-14
Filing date: 2020-07-14
Publication date: 2021-10-29
Anticipated expiration: 2040-07-14
Also published as: CN111840448A

Abstract

The invention discloses a preparation method and application of anti-chapping compound traditional Chinese medicine liposome. The preparation method comprises the following steps: selecting aloe: calamus: and (3) chamomile: and (3) kudingcha: cinnamon: myrrh: the weight ratio of the dandelion is 1-3:3-4:4-5:2-4:1-2:1-2:1-3, heating and refluxing the mixture by ethanol, and filtering and adsorbing the mixture by using activated carbon to obtain a light yellow-green compound traditional Chinese medicine extract; dissolving phospholipid in ethanol, and shaking with probe-type ultrasonic shaker to obtain uniform suspension while maintaining the temperature at 55-65 deg.C; and (3) taking part of the suspension, quickly injecting the suspension into the compound traditional Chinese medicine extract, heating and stirring the suspension at 40-50 ℃, and volatilizing the suspension to the original weight of the compound traditional Chinese medicine extract to obtain the compound traditional Chinese medicine liposome. The liposome prepared from the compound traditional Chinese medicine extract has a proven drug delivery mechanism, the structure of liposome phospholipid bilayer is similar to that of cell membrane, so that percutaneous absorption can be enhanced, active substances can be slowly released while being protected, and antioxidant is not required to be added, so that the final effect can be ensured.

Description

Preparation method and application of anti-chapping compound traditional Chinese medicine liposome

Technical Field

The invention relates to a traditional Chinese medicine liposome, belongs to the technical field of traditional Chinese medicine formula products, and particularly relates to a preparation method and application of an anti-chapping compound traditional Chinese medicine liposome.

Background

Rhagadia, also known as rhagadia manus et pedis, is a common skin disease, which refers to a disease of dry skin and linear fissures of the skin of hands and feet due to various reasons. The skin care cream is mainly applied to cold areas in northern China, a large number of patients are suffered, and the skin is often rubbed to lose moisture and dryness to form chaps due to less sweat in winter. It is often seen in the palm, ten fingertips, hand, foot, heel, and face of children, with cracks of different length and depth, and bleeding and severe pain in deep patients.

Over the last decade, the disease has also been common in southern regions of our country, which may be related to dryness, to occupation, and especially to physical workers. Some people may need to wash clothes and cook rice every day, touch some fat-soluble or alkaline substances, the skin of hands and feet is often dry and cracked due to lack of moisture, severe people have chaps which can reach deep muscle layers, and skin damage is from chaps to chaps, so that the pain is hard to endure. The rhagades of hands and feet should be prevented and treated in combination, the prevention is more important than the treatment, otherwise once the rhagades are formed, the rhagades are difficult to cure, the rhagades not only affect the activities of hands and feet but also affect the work and the life for a long time, and a plurality of patients in China need to be paid attention.

The rhagades of hands and feet are easy to develop for physical workers, so the price of the traditional rhagades prevention preparation is popular with workers and farmers for a certain period in the past.

The traditional Chinese medicine is a unique medicine used for preventing and treating diseases in the traditional Chinese medicine, and a compound traditional Chinese medicine plant extract formed by matching various traditional Chinese medicines is a countless number and is also an important mark for distinguishing the traditional Chinese medicine from other medicines. In the treatment of the new coronary pneumonia, the traditional Chinese medicine treatment plays an irreplaceable role in western medicine and further shows an exclamatory effect. The Chinese traditional medicine used in various places of China reaches about 5000 kinds, and after thousands of years of research, an independent science-materia medica is formed.

The urea has good skin conditioning effect as a humectant, the concentration of the urea added into the anti-chapping cream with good effect is high, but the urea has the problem of chemical stability, so that the prepared cream has the problem of long-term stability, which is mainly characterized in that the pH value of the preparation is gradually increased due to the gradual decomposition of the urea under the condition of long-term storage, the ammonia smell is generated, the cream is likely to turn yellow, the effect is continuously weakened, and therefore, strong essence and pigment are required to be added in order to cover the ammonia smell generated in the future during the formula design, and the natural and safe trend of modern consumption concept is not met.

Vitamin E is a good wound healing promoting ingredient, and is also a good antioxidant, but is also most susceptible to oxidative yellowing. The small amount of the additive can be used for stabilizing oil and avoiding rancidity of the oil and fat. However, if the composition is used as a wound healing component, a high concentration dosage is required, and the ointment tends to turn yellow and weaken in effect after long-term storage, so that a problem of discoloration which may occur in the future is generally covered by adding a pigment during formulation design.

The compound traditional Chinese medicine extract as an active ingredient is also easily oxidized and loses activity, so that some antioxidants are also added to maintain the activity of the compound traditional Chinese medicine extract, and meanwhile, because of the lack of a drug delivery mechanism, most of the active ingredients stay in the ointment, and few active ingredients really enter cells to participate in the skin repair function, so that the effect is also poor and satisfactory and needs to be improved.

Disclosure of Invention

Aiming at the problems in the prior art, the invention aims to provide an anti-chapping compound traditional Chinese medicine liposome, wherein a compound traditional Chinese medicine extract is prepared into the liposome, a proven administration mechanism exists, the structure of liposome phospholipid bilayer is similar to that of cell membrane, the percutaneous absorption can be enhanced, the active substances can be slowly released while being protected, and the final effect can be ensured without adding antioxidant.

The invention discloses a preparation method of anti-chapping compound traditional Chinese medicine liposome, which comprises the following steps,

1) selecting aloe: calamus: and (3) chamomile: and (3) kudingcha: cinnamon: myrrh: the dandelion is in a weight ratio of 1-3:3-4:4-5:2-4:1-2:1-2:1-3, ethanol is heated and refluxed for extraction, and activated carbon is used for filtration and adsorption treatment to obtain a light yellow green compound traditional Chinese medicine extract;

2) dissolving phospholipid in 85-99% ethanol, wherein each 1g of phospholipid composition corresponds to 10-15 g of ethanol;

3) vibrating with a probe-type ultrasonic vibrator to obtain a uniform suspension while maintaining the temperature at 55-65 deg.C;

4) then taking part of the suspension, and quickly injecting into the compound traditional Chinese medicine extract, wherein each 1g of the suspension corresponds to 3-6g of the compound traditional Chinese medicine extract; heating and stirring at 40-50 deg.C, and volatilizing to original weight of the compound Chinese medicinal extract to obtain compound Chinese medicinal liposome.

Further, in step 1), aloe: calamus: and (3) chamomile: and (3) kudingcha: cinnamon: myrrh: the weight ratio of the dandelion is 2: 3.5: 4.2: 3: 1.7: 1.5: 2.

further, in the step 1), the concentration of ethanol is 85-99%, the temperature is 60-70 ℃, the dosage of ethanol for each 1g of compound traditional Chinese medicine is 23-26mL, the extraction times are 1-3, and each time is 120-240 min.

Further, in step 2), shaking is carried out for 10-20min with 4s pulse per second amplitude of 5, so as to obtain uniform suspension.

Further, in the step 2), 0.5-2g of cholesterol can be added into every 1g of phospholipid; wherein, the phospholipid includes but is not limited to saturated hydrogenated lecithin, phosphatidylcholine, dipalmitoylphosphatidylcholine, dipalmitoylphosphatidylethanolamine, and distearoylphosphatidylcholine.

The invention also discloses the anti-chapping compound traditional Chinese medicine liposome prepared by the preparation method of the anti-chapping compound traditional Chinese medicine liposome.

In addition, the invention also discloses an anti-chapping cream which comprises 3.2 to 15.9 weight percent of component A, 17.85 to 39.3 weight percent of component B, 4.35 to 9.4 weight percent of component C and the balance of water, wherein:

the component A comprises the following components in percentage by weight: 2-10% of compound traditional Chinese medicine liposome, 0.3-0.8% of caprylyl hydroximic acid, 0.1-1% of ethylhexyl glycerol, 0.2-0.5% of 1, 2-hexanediol, 0.1-0.6% of triethanolamine and 0.5-3% of coconut fruit extract;

the component B comprises the following components in percentage by weight: 2.0 to 4.0 percent of glyceryl stearate, 0.3 to 1.8 percent of polyglycerol-3 diisostearate, 2 to 6 percent of cetostearyl alcohol, 6 to 10 percent of vaseline, 2 to 6 percent of liquid paraffin, 5 to 8 percent of isononyl isononanoate, 0.1 to 1 percent of silicone oil, 0.05 to 0.5 percent of argan tree oil, 0.1 to 0.5 percent of macadamia nut oil, 0.1 to 0.5 percent of shea butter, 0.1 to 0.5 percent of grass cotton seed oil and 0.1 to 0.5 percent of olive oil;

the component C comprises the following components in percentage by weight: 4-8% of glycerol, 0.1-0.5% of xanthan gum, 0.1-0.4% of acrylic cross-linked polymer, 0.1-0.3% of allantoin and 0.05-0.2% of EDTA disodium.

Further, the component a contains:

5-9% of compound traditional Chinese medicine liposome, 0.4-0.7% of caprylyl hydroximic acid, 0.1-0.7% of ethylhexyl glycerol, 0.2-0.4% of 1, 2-hexanediol, 0.2-0.4% of triethanolamine and 1-2% of coconut fruit extract;

the component B contains: 2.6 to 3.5 percent of glyceryl stearate, 0.5 to 1.3 percent of polyglycerol-3 diisostearate, 3 to 5 percent of cetostearyl alcohol, 7 to 9 percent of vaseline, 3 to 5 percent of liquid paraffin, 5.2 to 7.5 percent of isononyl isononanoate, 0.2 to 0.8 percent of silicone oil, 0.1 to 0.4 percent of argania spinosa kernel oil, 0.2 to 0.4 percent of macadamia nut oil, 0.2 to 0.4 percent of shea butter, 0.2 to 0.4 percent of gossypium hirsutum seed oil and 0.2 to 0.4 percent of olive oil;

the component C contains: 5-7% of glycerol, 0.2-0.4% of xanthan gum, 0.2-0.4% of acrylic cross-linked polymer, 0.1-0.2% of allantoin and 0.1-0.2% of EDTA disodium.

The balance being the percentage balance of water.

Further, the preparation method of the anti-chapping cream comprises the following specific preparation process steps:

1) heating water to 40-45 ℃, adding the component A into the water, stirring to obtain a mixed solution A, and keeping the temperature for later use;

2) heating the component B to 70-80 ℃, stirring and homogenizing to obtain a mixed solution B, and keeping the temperature for later use;

3) heating water to 75-85 ℃, adding the component C into the water, stirring uniformly, adding the mixed solution B obtained in the step 2), and homogenizing until complete emulsification.

4) Then cooling to 40-45 ℃, and adding the component A obtained in the step (1). And continuously stirring to room temperature to obtain the anti-chapping paste.

By means of the technical scheme, the invention has the following advantages and beneficial technical effects:

1) the invention selects 7 components of Chinese medicinal raw materials of aloe, calamus, chamomile, ilex latifolia thumb, cinnamon, myrrh and dandelion to prepare the anti-chapping compound Chinese medicinal liposome.

2) The anti-chapping compound traditional Chinese medicine liposome has no influence on the smell, color and pH value of the prepared ointment, and has good long-term stability compared with the traditional anti-chapping ointment, so that the shelf life of a final product and the service life of a consumer can be prolonged.

2) The anti-chapping compound traditional Chinese medicine liposome is prepared from the compound traditional Chinese medicine extract, has a proven administration mechanism, has a structure similar to that of a cell membrane, can enhance percutaneous absorption, can slowly release active substances while protecting the active substances, does not need to add an antioxidant, and ensures the final effect.

Drawings

FIG. 1 is a graph of type III defined chapped foot of a patient in the anti-chapping test of the present invention.

FIG. 2 is a graph of type II defined chapped foot in the anti-chapping test of the present invention.

FIG. 3 is a graph of type I defined chapping of a patient's foot in the anti-chapping test of the present invention.

Detailed Description

The present invention will be described in more detail below with reference to specific preferred embodiments and examples of effect tests, but the present invention is not limited to the following examples.

The invention discloses an anti-chapping compound traditional Chinese medicine liposome, which is defined by the pharmaceutics of the liposome: refers to a microvesicle formed by encapsulating a drug in a lipid bilayer.

The invention discloses a preparation method and application of anti-chapping compound traditional Chinese medicine liposome. The preparation method comprises the following steps:

1) selecting aloe: calamus: and (3) chamomile: and (3) kudingcha: cinnamon: myrrh: the weight ratio of the dandelion is 1-3:3-4:4-5:2-4:1-2:1-2:1-3, heating and refluxing the mixture by ethanol, and filtering and adsorbing the mixture by using activated carbon to obtain a light yellow-green compound traditional Chinese medicine extract;

2) dissolving phospholipid in ethanol, and shaking with probe-type ultrasonic shaker to obtain uniform suspension while maintaining the temperature at 55-65 deg.C;

3) and quickly injecting part of the suspension into the compound Chinese medicinal extract, heating and stirring at 40-50 deg.C, and volatilizing to the original weight of the compound Chinese medicinal extract to obtain compound Chinese medicinal liposome.

The liposome prepared from the compound traditional Chinese medicine extract has a proven drug delivery mechanism, the structure of liposome phospholipid bilayer is similar to that of cell membrane, the percutaneous absorption can be enhanced, the active substances can be slowly released while being protected, and the final effect can be ensured without adding antioxidant.

The theory of etiology of various diseases, the deficient honor hand and foot skin exfoliating: blood circulation promoting and nourishing the five internal organs, qi of the five internal organs, nourishing the skin. The skin is peeled off because of the deficiency-consuming internal injury, blood and qi failing to nourish the skin. "

The "orthodox surgery and hand and foot rupture": the condition of cracked hands and feet, dry and dry, failure of qi and blood to nourish them is also indicated. The skin is gradually withered and the skin is broken because the hot muscles are forced by wind cold and stagnates the blood vessels; it usually attacks wind and is accompanied by wind-heat, so it usually causes pain.

The "etiology and pathogenesis of various diseases & meat fissure" (the theory of disease origin and meat fissure): for cracked meat, skin and meat are not too cracked. It is considered that the flesh is not cracked due to the weak striae and wind pathogen attacking the blood.

The treatment of symptoms and signs is called rope-treating ulcer medicine: for example, Fu Qiu Dong and Dong due to wind-cold dryness and severe wind-cold, the hands and feet are cracked chilblain, which is apt to be injured due to blood deficiency and skin deficiency.

Therefore, the traditional Chinese medicine considers that wind evil, damp evil, heat evil, blood deficiency, worm excesses and the like are the main causes of diseases, so that the selection of the traditional Chinese medicinal materials has the principles of expelling and killing the pathogenic factors, clearing away heat and toxic materials, nourishing yin and moistening dryness, dispelling wind and clearing heat, warming and dredging channels, diminishing inflammation and relieving pain, and reducing swelling and promoting tissue regeneration.

The drug selects calamus as the drug for eliminating pathogenic factors and insects, selects dandelion as the drug for nourishing yin and moistening dryness, selects aloe as the drug for killing insects and treating malnutrition, selects broadleaf holly leaf as the drug for dispelling wind and clearing heat, selects cinnamon as the drug for warming and dredging channels, selects chamomile as the drug for diminishing inflammation and relieving pain, selects myrrh as the drug for diminishing swelling and promoting tissue regeneration,

the raw material composition of the compound traditional Chinese medicine extract is introduced to have the following effects respectively:

aloe

Ben Cao Jing Shu (the book of materia Medica Prime and Dredging): aloe is the essential herb for removing heat and killing parasites because it can clear heat, expel heat and dry dampness, and kill parasites. According to modern medical analysis, aloe contains 75 elements such as beta-carotene, aloin A, aloesin, aloe emodin glycoside, alomycin, aloe polysaccharide and the like. The aloin A and the aloe polysaccharide also have obvious curative effects on various burns, scalds and sunburns, and have the functions of moisturizing, diminishing inflammation, sterilizing, absorbing heat, reducing swelling, softening skin, inhibiting filtration viruses, mold and cancer cells, promoting wound healing and recovery and maintaining cell activity. The aloe calcium isocitrate has effects of promoting blood circulation, softening and hardening artery, dilating capillary blood vessel, and promoting blood circulation. The mucin in aloe is an important component for preventing cell aging and treating chronic allergy. Mucin exists in human muscle and gastrointestinal mucosa, and makes the tissue elastic, and if insufficient mucin is available, the muscle and mucosa lose elasticity and become rigid and aging.

Rhizoma Acori Calami

Rhizoma Acori Calami, the name of Chinese medicine. Compendium of materia Medica: for tinnitus, head wind, tear, ghost qi, parasites, malignant sores and scabies. Remove all malignant diseases and relieve all toxicity. All the provinces in the country produce the oil. Has the effects of killing parasites and eliminating pathogenic factors. It is commonly used for phlegm syncope coma, apoplexy, epilepsy, palpitation, amnesia, tinnitus, deafness, dyspepsia, abdominal pain, dysentery, diarrhea, rheumatalgia, eczema, and scabies. Meanwhile, the calamus has the effects of repelling mosquitoes and insects, repelling pathogenic plagues, removing dampness and detoxifying, so the calamus is regarded as a pathogenic matter.

③ Matricaria chamomilla

From the age when the old medicine is not available, chamomile is used as a good medicine for diminishing inflammation and relieving pain by the old. In 1981, the Shipochliev et al scholars verified the anti-inflammatory efficacy of chamomile through tests.

Tea of bitter leaves

The broadleaf holly leaf tea has the effects of dispelling wind, clearing heat, improving eyesight and promoting the secretion of saliva or body fluid. Headache due to wind-heat; dental pain; conjunctival congestion; purulent otitis media; aphtha; fever with polydipsia; diarrhea; dysentery is caused.

Cortex Cinnamomi

Chinese pharmacopoeia: the medicine has the effects of tonifying fire and yang, guiding fire to the origin, dispelling cold and relieving pain, and warming and dredging channels and collaterals, and is used for treating impotence and cold womb, waist paint cold pain, deficiency of the kidney and asthma, deficiency yang floating, vertigo and conjunctival congestion, heart and abdomen cold pain, deficiency cold vomiting and diarrhea, cold hernia and abdominal pain, dysmenorrheal and amenorrhea.

Novel use of myrrh

The materia Medica of sea drugs: "mainly fracture and hurt the pendant, push old and replace new, can generate good blood". Chinese pharmacopoeia: has the functions of eliminating blood stasis, relieving pain, eliminating swelling, promoting granulation and treating iron injury. Modern medicine considers that myrrh can resist bacteria, microbes and inflammation, cure wounds, kill mould and is beneficial to chapped and rough skin.

(rhizome of Chinese dandelion)

Chinese pharmacopoeia: clear heat and remove toxicity, resolve swelling and dissipate nodulation.

The dandelion plant contains various health nutritional components such as taraxol, taraxacin, choline, organic acid, inulin, etc. Sweet in nature and taste, slightly bitter and cold. It enters liver and stomach meridians. Has diuretic, laxative, jaundice treating, and gallbladder promoting effects. It is used to treat heat-toxin, carbuncle, pyocutaneous disease, internal carbuncle, conjunctival congestion, swelling and pain, damp-heat, jaundice, stranguria with urine, furuncle, acute mastitis, scrofula, toothache, conjunctival congestion, pharyngalgia, pulmonary abscess, intestinal abscess, damp-heat jaundice, and stranguria with pain. It can be used for treating acute mastitis, lymphadenitis, lymphoid tuberculosis, furunculosis, acute conjunctivitis, common cold with fever, acute tonsillitis, acute bronchitis, gastritis, hepatitis, cholecystitis, and urinary tract infection. The herba Taraxaci can be eaten raw, fried and used as soup, and is a plant used as both medicine and food.

The following are preparation method examples 1-3 of the anti-chapping compound traditional Chinese medicine liposome of the invention.

Example 1

A preparation method of anti-chapping compound traditional Chinese medicine liposome specifically comprises the following process steps:

1) selecting aloe: calamus: and (3) chamomile: and (3) kudingcha: cinnamon: myrrh: the weight ratio of the dandelion is 2: 3.5: 4.2: 3: 1.7: 1.5: 2, heating and refluxing the mixture by using ethanol, wherein the concentration of the ethanol is 85 percent, the temperature is 60 ℃, the dosage of the ethanol for each 1g of the compound traditional Chinese medicine is 23mL, the extraction times are 3 times, each time is 120min, and the mixture is filtered and adsorbed by using activated carbon to obtain the light yellow-green compound traditional Chinese medicine extract.

2) The phospholipids were dissolved in 85% ethanol in an amount of 10g of ethanol per 1g of phospholipid composition.

3) Shaking with a probe-type ultrasonic shaker at 4s pulse amplitude of 5/s for 15min to obtain a uniform suspension while maintaining the temperature at 55 deg.C.

4) And then taking part of the suspension, and quickly injecting the suspension into the compound traditional Chinese medicine extract, wherein each 1g of the suspension corresponds to 3g of the compound traditional Chinese medicine extract. Heating and stirring at 40 deg.C to volatilize to original weight of the compound Chinese medicinal extract to obtain compound Chinese medicinal liposome.

Example 2

1) selecting aloe: calamus: and (3) chamomile: and (3) kudingcha: cinnamon: myrrh: the weight ratio of the dandelion is 1: 3: 4: 2: 1: 1: 2, heating and refluxing the mixture with ethanol, wherein the concentration of the ethanol is 99 percent, the temperature is 70 ℃, the dosage of the ethanol for each 1g of the compound traditional Chinese medicine is 26mL, the extraction times are 3 times, and each time is 240min, and the mixture is filtered and adsorbed by active carbon to obtain a light yellow-green compound traditional Chinese medicine extract;

2) dissolving phospholipids in 99% ethanol in an amount of 15g of ethanol per 1g of the phospholipid composition;

3) oscillating for 20min at 4s pulse per second amplitude of 5 s by using a probe-type ultrasonic oscillator to obtain a uniform suspension, and keeping the temperature at 65 ℃;

4) then taking part of the suspension, and quickly injecting the suspension into the compound traditional Chinese medicine extract, wherein each 1g of the suspension corresponds to 6g of the compound traditional Chinese medicine extract; heating and stirring at 50 deg.C, and volatilizing to original weight of the compound Chinese medicinal extract to obtain compound Chinese medicinal liposome.

Example 3

1) selecting aloe: calamus: and (3) chamomile: and (3) kudingcha: cinnamon: myrrh: the weight ratio of the dandelion is 3: 4: 5: 4: 2: 2: 3, heating and refluxing the mixture with ethanol, wherein the concentration of the ethanol is 95 percent, the temperature is 65 ℃, the dosage of the ethanol for each 1g of the compound traditional Chinese medicine is 25mL, the extraction times are 2 times, and each time is 200min, and the mixture is filtered and adsorbed by active carbon to obtain a light yellow-green compound traditional Chinese medicine extract;

2) dissolving phospholipids in 95% ethanol in an amount of 12g of ethanol per 1g of the phospholipid composition;

3) shaking with 4s pulse per second amplitude of 5 s for 15min by using a probe-type ultrasonic shaker to obtain a uniform suspension while maintaining the temperature at 60 deg.C;

4) then taking part of the suspension, and quickly injecting the suspension into the compound traditional Chinese medicine extract, wherein each 1g of the suspension corresponds to 5g of the compound traditional Chinese medicine extract; heating and stirring at 45 deg.C, and volatilizing to original weight of the compound Chinese medicinal extract to obtain compound Chinese medicinal liposome.

In the step 2) of the preparation method of the liposome, 0.5-2g of cholesterol can be added into 1g of phospholipid, so that a better effect can be achieved. Wherein the phospholipid includes, but is not limited to, saturated hydrogenated lecithin, phosphatidylcholine, dipalmitoylphosphatidylcholine, dipalmitoylphosphatidylethanolamine, distearoylphosphatidylcholine.

The following are preparation process examples 4 to 6 of anti-chapping cream containing anti-chapping compound traditional Chinese medicine liposome of examples 1 to 3 of the present invention, respectively.

Example 4

An anti-chapping cream comprises, by weight, 3.2% of component A, 17.85% of component B, 4.35% of component C and the balance of water, wherein:

the component A contains: 2% of compound traditional Chinese medicine liposome, 0.3% of caprylyl hydroximic acid, 0.1% of ethylhexyl glycerol, 0.2% of 1, 2-hexanediol, 0.1% of triethanolamine and 0.5% of coconut fruit extract;

the component B contains: 2.0% of glyceryl stearate, 0.3% of polyglyceryl-3-diisostearate, 2% of cetostearyl alcohol, 6% of vaseline, 2% of liquid paraffin, 5% of isononyl isononanoate, 0.1% of silicone oil, 0.05% of argan nut oil, 0.1% of macadamia nut oil, 0.1% of shea butter, 0.1% of gossypium herbaceum seed oil and 0.1% of olive oil;

the component C contains: 4% of glycerin, 0.1% of xanthan gum, 0.1% of acrylic cross-linked polymer, 0.1% of allantoin and 0.05% of EDTA disodium.

The balance being the percentage balance of water.

Example 5

An anti-chapping cream comprises 9.3 percent of component A, 27.2 percent of component B, 6.3 percent of component C, and comprises the component A, the component B, the component C and the balance of water in percentage by weight, wherein:

the component A contains: 8% of compound traditional Chinese medicine liposome, 0.5% of caprylyl hydroximic acid, 0.1% of ethylhexyl glycerol, 0.3% of 1, 2-hexanediol, 0.3% of triethanolamine and 0.1% of coconut fruit extract;

the component B contains: 2.8% of glyceryl stearate, 0.7% of polyglyceryl-3-diisostearate, 4% of cetostearyl alcohol, 8% of vaseline, 4% of liquid paraffin, 6% of isononyl isononanoate, 0.3% of silicone oil, 0.2% of argan nut oil, 0.2% of macadamia nut oil, 0.3% of shea butter, 0.4% of gossypium herbaceum seed oil and 0.3% of olive oil;

the component C contains: 5.5% of glycerin, 0.25% of xanthan gum, 0.3% of acrylic cross-linked polymer, 0.1% of allantoin and 0.15% of EDTA disodium.

The balance being the percentage balance of water.

Example 6

An anti-chapping cream comprises 9.9 percent of component A, 39.3 percent of component B and 9.4 percent of component C, wherein the component A, the component B, the component C and the balance of water in percentage by weight, wherein:

the component A contains: 4% of compound traditional Chinese medicine liposome, 0.8% of caprylyl hydroximic acid, 1.0% of ethylhexyl glycerol, 0.5% of 1, 2-hexanediol, 0.6% of triethanolamine and 3% of coconut fruit extract;

the component B contains: 4.0% of glyceryl stearate, 1.8% of polyglyceryl-3-diisostearate, 6% of cetostearyl alcohol, 10% of vaseline, 6% of liquid paraffin, 8% of isononyl isononanoate, 1.0% of silicone oil, 0.5% of argan nut oil, 0.5% of macadamia nut oil, 0.5% of shea butter, 0.5% of gossypium herbaceum seed oil and 0.5% of olive oil;

the component C contains: 8% of glycerin, 0.5% of xanthan gum, 0.4% of acrylic cross-linked polymer, 0.3% of allantoin and 0.2% of EDTA disodium.

The balance being the percentage balance of water.

The preparation method of the anti-chapping cream of the above embodiment 4-6 comprises the following specific steps:

3) heating water to 75-85 ℃, adding the component C into the water, uniformly stirring, adding the mixed solution B obtained in the step 2), and homogenizing until complete emulsification;

4) cooling to 40-45 ℃, and adding the component A obtained in the step 1); and continuously stirring to room temperature to obtain the anti-chapping cream.

In an anti-chapping cream, 0.1-0.3 of tocopherol can be added into the component A to achieve better effect.

The following are contents of the effect test examples.

Effect test example 1 (Long-term stability test)

The long-term stability test was carried out according to the cosmetic QB/T1857 and the physicochemical extraordinary routine shown in Table 1.

TABLE 1 cosmetic QB/T1857 and physico-chemical extraordinary Long-term stability tests

As shown in the data in table 1, in the control 1, the pH value was increased to an indefinite extent and the pastes were off-flavored and discolored even when the temperature was higher than the ordinary temperature for three months. Meanwhile, in the case that the pH value, the smell and the color of the compound traditional Chinese medicine liposome are normal under the condition that the temperature is higher than the normal temperature for three months, the compound traditional Chinese medicine liposome has no influence on the preparation of the ointment and has good long-term stability.

Effect test example 2 (anti-chapping test)

The following Table 2 shows the formulation compositions of the raw material components of examples 7-8 and control groups 1-2.

TABLE 2 raw material component formulation (% by weight) of examples 7-8 and control 1-2

Tables 3 and 4 show that 46 patients with type III foot rhagades were clinically tested in two groups of 23 patients, wherein the patients were applied once in the morning and at night for 14 days, and observed and recorded the foot rhagades of the patients on the 0 th, 3 th, 7 th, 10 th and 14 th days. As shown in connection with figures 1-3,

FIG. 1 shows the definition of type III: the epidermis is seriously keratinized, the cuticle is thick, the skin is very dry, and more than 1 obvious and deep linear crack exists, so the bleeding and the pain are difficult to endure.

FIG. 2 shows the definition of type II: the epidermis is cornified, the skin is dry, more than 1 linear fissure is formed, bleeding is avoided, and no pain or slight pain is caused.

FIG. 3 shows the definition of form I: the epidermis is slightly keratinized, the skin is smooth, no obvious linear fissure exists, no bleeding occurs, and no pain is caused.

Table 3 example 8 and control 2 patients with chapped feet were clinically tested in a total of 46 patients

Table 4 example 8 and control 2. a total of 46 patients with rhagades of feet were subjected to clinical test proportion analysis

As shown by the data in tables 2-3, 23 patients in control group 2 had a form III proportion of 0% and a form I proportion of 60.87% at day 14.

The 23 patients in example 8 who corresponded to this had all a form iii percentage of 0% at day 7 and a form i percentage of up to 95.65% at day 14. The compound traditional Chinese medicine liposome is better in chap prevention effect than the compound traditional Chinese medicine extract.

The above description is only a preferred embodiment of the present invention, and is not intended to limit the present invention in any way, so that any simple modification, equivalent change and modification made to the above embodiment according to the technical spirit of the present invention are within the scope of the technical solution of the present invention.

Claims

1. A preparation method of anti-chapping compound traditional Chinese medicine liposome is characterized by comprising the following steps:

2. The preparation method of the anti-chapping compound traditional Chinese medicine liposome as claimed in claim 1, wherein: in step 1), aloe: calamus: and (3) chamomile: and (3) kudingcha: cinnamon: myrrh: the weight ratio of the dandelion is 2: 3.5: 4.2: 3: 1.7: 1.5: 2.

3. the preparation method of the anti-chapping compound traditional Chinese medicine liposome as claimed in claim 1, wherein: in the step 1), the concentration of the ethanol is 85-99%, the temperature is 60-70 ℃, the dosage of the ethanol corresponding to each 1g of the compound traditional Chinese medicine is 23-26mL, the extraction times are 1-3 times, and each time is 120-fold for 240 min.

4. The preparation method of the anti-chapping compound traditional Chinese medicine liposome as claimed in claim 1, wherein: in the step 3), 4s pulse per second with amplitude of 5 is oscillated for 10-20min to form uniform suspension.

5. The preparation method of the anti-chapping compound traditional Chinese medicine liposome as claimed in claim 1, wherein: in the step 2), 0.5-2g of cholesterol can be added into each 1g of phospholipid; wherein, the phospholipid includes but is not limited to one or more of saturated hydrogenated lecithin, phosphatidylcholine, dipalmitoylphosphatidylcholine, dipalmitoylphosphatidylethanolamine and distearoylphosphatidylcholine.

6. The anti-chapping compound traditional Chinese medicine liposome prepared by the preparation method of the anti-chapping compound traditional Chinese medicine liposome according to any one of claims 1 to 5.

7. An anti-chapping cream, characterized in that the anti-chapping cream comprises 3.2-15.9% of component A, 17.85-39.3% of component B, 4.35-9.4% of component C and the balance of water by weight percentage, wherein:

the component A comprises the following components in percentage by weight:

2-10% of anti-chapping compound traditional Chinese medicine liposome as claimed in claim 6, 0.3-0.8% of caprylyl hydroximic acid, 0.1-1% of ethylhexyl glycerol, 0.2-0.5% of 1, 2-hexanediol, 0.1-0.6% of triethanolamine, 0.5-3% of coconut fruit extract;

the component B comprises the following components in percentage by weight:

2.0 to 4.0 percent of glyceryl stearate, 0.3 to 1.8 percent of polyglycerol-3 diisostearate, 2 to 6 percent of cetostearyl alcohol, 6 to 10 percent of vaseline, 2 to 6 percent of liquid paraffin, 5 to 8 percent of isononyl isononanoate, 0.1 to 1 percent of silicone oil, 0.05 to 0.5 percent of argan tree oil, 0.1 to 0.5 percent of macadamia nut oil, 0.1 to 0.5 percent of shea butter, 0.1 to 0.5 percent of grass cotton seed oil and 0.1 to 0.5 percent of olive oil;

the component C comprises the following components in percentage by weight:

4 to 8 percent of glycerin, 0.1 to 0.5 percent of xanthan gum, 0.1 to 0.4 percent of acrylic cross-linked polymer, 0.1 to 0.3 percent of allantoin, 0.05 to 0.2 percent of EDTA disodium,

the balance being the percentage balance of water.

8. The anti-chapping cream according to claim 7, wherein:

the component A contains: 5-9% of anti-chapping compound traditional Chinese medicine liposome, 0.4-0.7% of caprylyl hydroximic acid, 0.1-0.7% of ethylhexyl glycerol, 0.2-0.4% of 1, 2-hexanediol, 0.2-0.4% of triethanolamine and 1-2% of coconut fruit extract;

the component C contains: 5 to 7 percent of glycerin, 0.2 to 0.4 percent of xanthan gum, 0.2 to 0.4 percent of acrylic cross-linked polymer, 0.1 to 0.2 percent of allantoin, 0.1 to 0.2 percent of EDTA disodium,

the balance being the percentage balance of water.

9. The anti-chapping cream as claimed in claim 8, which is prepared by the following steps:

3) heating water to 75-85 ℃, adding the component C into the water, stirring uniformly, adding the mixed solution B obtained in the step 2), homogenizing until complete emulsification is achieved,

4) cooling to 40-45 ℃, adding the component A obtained in the step 1), and continuously stirring to room temperature to obtain the anti-cracking paste.