[go: up one dir, main page]
More Web Proxy on the site http://driver.im/

CN111793528A - Antibacterial phosphorus-free cleaning agent and preparation method and application thereof - Google Patents

Antibacterial phosphorus-free cleaning agent and preparation method and application thereof Download PDF

Info

Publication number
CN111793528A
CN111793528A CN202010732788.0A CN202010732788A CN111793528A CN 111793528 A CN111793528 A CN 111793528A CN 202010732788 A CN202010732788 A CN 202010732788A CN 111793528 A CN111793528 A CN 111793528A
Authority
CN
China
Prior art keywords
cleaning agent
free cleaning
antibacterial
phosphorus
antibacterial phosphorus
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202010732788.0A
Other languages
Chinese (zh)
Inventor
左展
黄涛
张娟丽
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Zhengzhou Labscience Co ltd
Original Assignee
Zhengzhou Labscience Co ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zhengzhou Labscience Co ltd filed Critical Zhengzhou Labscience Co ltd
Priority to CN202010732788.0A priority Critical patent/CN111793528A/en
Publication of CN111793528A publication Critical patent/CN111793528A/en
Pending legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C11ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11DDETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D1/00Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
    • C11D1/66Non-ionic compounds
    • C11D1/825Mixtures of compounds all of which are non-ionic
    • CCHEMISTRY; METALLURGY
    • C11ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11DDETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/0005Other compounding ingredients characterised by their effect
    • C11D3/0073Anticorrosion compositions
    • CCHEMISTRY; METALLURGY
    • C11ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11DDETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/0005Other compounding ingredients characterised by their effect
    • C11D3/0094High foaming compositions
    • CCHEMISTRY; METALLURGY
    • C11ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11DDETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/02Inorganic compounds ; Elemental compounds
    • C11D3/04Water-soluble compounds
    • C11D3/042Acids
    • CCHEMISTRY; METALLURGY
    • C11ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11DDETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16Organic compounds
    • C11D3/20Organic compounds containing oxygen
    • C11D3/2003Alcohols; Phenols
    • C11D3/2006Monohydric alcohols
    • C11D3/201Monohydric alcohols linear
    • CCHEMISTRY; METALLURGY
    • C11ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11DDETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16Organic compounds
    • C11D3/26Organic compounds containing nitrogen
    • C11D3/30Amines; Substituted amines ; Quaternized amines
    • CCHEMISTRY; METALLURGY
    • C11ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11DDETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16Organic compounds
    • C11D3/34Organic compounds containing sulfur
    • C11D3/3418Toluene -, xylene -, cumene -, benzene - or naphthalene sulfonates or sulfates
    • CCHEMISTRY; METALLURGY
    • C11ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11DDETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/48Medical, disinfecting agents, disinfecting, antibacterial, germicidal or antimicrobial compositions
    • CCHEMISTRY; METALLURGY
    • C11ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11DDETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D1/00Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
    • C11D1/66Non-ionic compounds
    • C11D1/72Ethers of polyoxyalkylene glycols

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Emergency Medicine (AREA)
  • Inorganic Chemistry (AREA)
  • Detergent Compositions (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

The invention provides an antibacterial phosphorus-free cleaning agent and a preparation method and application thereof, wherein each 1L of the antibacterial phosphorus-free cleaning agent comprises the following components: nonylphenol polyoxyethylene ether TX-710-20 ml, nonylphenol polyoxyethylene ether TX-1220-45 ml, monoethanolamine 10-17ml, boric acid 2-4g, absolute ethyl alcohol 10-30ml, toluene-4-sodium sulfonate 1-2g and the balance of deionized water. The antibacterial phosphorus-free cleaning agent is suitable for a full-automatic biochemical analyzer, is colorless and transparent liquid in appearance, is stable in chemical property, and reduces the use cost while ensuring the test effect.

Description

Antibacterial phosphorus-free cleaning agent and preparation method and application thereof
Technical Field
The invention relates to the technical field of cleaning agents, in particular to an antibacterial phosphorus-free cleaning agent and a preparation method and application thereof.
Background
The full-automatic biochemical analyzer is an indispensable instrument and equipment for hospital clinical laboratory due to simple operation, reliable result and stable performance. The antibacterial phosphorus-free cleaning agent is also a necessity for daily operation of instruments, the consumption is high, and the antibacterial phosphorus-free cleaning agent in China mostly depends on import and is expensive, so that the medical cost is high. For example, Hitachi 7100, which is one of the most imported full-automatic biochemical analyzers, has the advantages of high detection speed, simple and convenient operation, good system repeatability, high accuracy and the like, the cleaning agent mainly adopts HITERGENT stock solution, HITERGENT stock solution is an imported cleaning agent, the price is higher, and although a small amount of domestic antibacterial phosphorus-free cleaning agent exists in the market at present, the actual effect is not ideal, and the requirements of customers cannot be met.
CN107881021A discloses a constant temperature bath cleaning solution and a preparation method thereof, wherein a bactericide of the constant temperature bath cleaning solution is Proclin 300, although Proclin 300 has low biological toxicity, the price is high, a surfactant is single TX-10, TX-10 only has single emulsifying capacity, and TX-10 is more in addition amount than TX-7, more viscous and not easy to weigh, triethanolamine basically crystallizes except in summer, is not easy to weigh, causes inconvenience for preparation of the cleaning solution, and is not beneficial to maintaining stability of cleaning solution performance.
Disclosure of Invention
The invention provides an antibacterial phosphorus-free cleaning agent, a preparation method and application thereof, which are suitable for a full-automatic biochemical analyzer.
The technical scheme of the invention is realized as follows: an antibacterial phosphorus-free cleaning agent, wherein each 1L of the antibacterial phosphorus-free cleaning agent contains: nonylphenol polyoxyethylene ether TX-710-20 ml, nonylphenol polyoxyethylene ether TX-1220-45 ml, monoethanolamine 10-17ml, boric acid 2-4g, absolute ethyl alcohol 10-30ml, toluene-4-sodium sulfonate 1-2g and the balance of deionized water.
Furthermore, each 1L of the antibacterial phosphorus-free cleaning agent contains: nonylphenol polyoxyethylene ether TX-715ml, nonylphenol polyoxyethylene ether TX-1230 ml, monoethanolamine 14ml, boric acid 3g, ethanol 20ml, toluene-4-sodium sulfonate 1.5g, and the balance of deionized water.
A preparation method of an antibacterial phosphorus-free cleaning agent comprises the following steps:
(1) adding monoethanolamine into deionized water to obtain a solution A, dissolving boric acid into absolute ethyl alcohol, uniformly mixing to obtain a solution B, adding the solution B into the solution A, and uniformly stirring to obtain a premixed solution;
(2) adding toluene-4-sodium sulfonate into the premixed solution obtained in the step (1), and uniformly stirring to obtain a mixed solution;
(3) and (3) adding nonylphenol polyoxyethylene ether TX-7 and nonylphenol polyoxyethylene ether TX-12 into the mixed solution obtained in the step (2), adding deionized water to a constant volume of 1L, uniformly stirring, and filtering to obtain the antibacterial phosphorus-free cleaning agent.
Further, in the step (2), a cellulose nitrate filter membrane with the pore size of 0.22um is adopted for filtration.
Further, the pH value of the antibacterial phosphorus-free cleaning agent is 10-10.5.
Further, the conductivity of the antibacterial phosphorus-free cleaning agent is 2-5 ms/cm.
Further, the osmotic pressure of the antibacterial non-phosphate cleaning agent is 600-800m0 sm/kg.
An application of antibacterial non-phosphorus detergent in full-automatic biochemical analyzer.
The invention has the beneficial effects that:
the antibacterial phosphorus-free cleaning agent is suitable for a full-automatic biochemical analyzer, is colorless and transparent liquid in appearance, has stable chemical properties, reduces the use cost while ensuring the test effect, saves the medical expenditure of people, is easy to popularize clinically, and has obvious social and economic benefits.
1. The invention adopts the toluene-4-sodium sulfonate as the solubilizer, reduces the viscosity and the turbidity of the cleaning agent, and has lower influence on the fluidity and the transparency of water after being added into the water bath.
2. The surfactant disclosed by the invention is a combination of TX-7 and TX-12, wherein TX-7 has excellent emulsification cleaning performance and stronger cleaning capability than other surfactants, but is diffused in water, and in addition, TX-12 is added to increase the water solubility of TX-7, and meanwhile, TX-12 is also a heavy-duty low-foaming lotion and can reduce the water hardness and increase the defoaming capability.
3. The monoethanolamine serving as the antirust agent can protect the sample sucking needle while washing the needle, and can provide an alkaline environment to wash off substances such as protein and the like on the sample sucking needle so as to prevent cross contamination; in addition, the monoethanolamine is liquid in most cases, the weighing is easy, and the monoethanolamine with the same concentration is dissolved in water, so that the PH value of the monoethanolamine is higher than that of triethanolamine, and the monoethanolamine is more favorable for corrosion prevention.
4. The preservative adopts boric acid to replace the common antibacterial agent sodium azide, has low toxicity and safe use, avoids the damage to reagent production personnel and environment, and can achieve the test effect equivalent to that of the antibacterial phosphorus-free cleaning agent in Hitachi original factories, but the cost is greatly reduced and the preparation method is simple.
Detailed Description
The technical solutions in the embodiments of the present invention are clearly and completely described below, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all embodiments. All other embodiments, which can be obtained by a person skilled in the art without inventive effort based on the embodiments of the present invention, are within the scope of the present invention.
An antibacterial phosphorus-free cleaning agent, wherein each 1L of the antibacterial phosphorus-free cleaning agent contains: nonylphenol polyoxyethylene ether TX-710-20 ml, nonylphenol polyoxyethylene ether TX-1220-45 ml, monoethanolamine 10-17ml, boric acid 2-4g, absolute ethyl alcohol 10-30ml, toluene-4-sodium sulfonate 1-2g and the balance of deionized water. The pH value of the antibacterial phosphorus-free cleaning agent is 10-10.5. The conductivity of the antibacterial phosphorus-free cleaning agent is 2-5 ms/cm. The osmotic pressure of the antibacterial non-phosphate cleaning agent is 600-.
The specific embodiment is as follows:
example 1
An antibacterial phosphorus-free cleaning agent, wherein each 1L of the antibacterial phosphorus-free cleaning agent contains: nonylphenol polyoxyethylene ether TX-715ml, nonylphenol polyoxyethylene ether TX-1230 ml, monoethanolamine 14ml, boric acid 3g, ethanol 20ml, toluene-4-sodium sulfonate 1.5g, and the balance of deionized water.
The preparation method of the antibacterial phosphorus-free cleaning agent comprises the following steps:
(1) adding monoethanolamine into deionized water to obtain a solution A, dissolving boric acid into absolute ethyl alcohol, uniformly mixing to obtain a solution B, adding the solution B into the solution A, and uniformly stirring to obtain a premixed solution;
(2) adding toluene-4-sodium sulfonate into the premixed solution obtained in the step (1), and uniformly stirring to obtain a mixed solution;
(3) and (3) adding nonylphenol polyoxyethylene ether TX-7 and nonylphenol polyoxyethylene ether TX-12 into the mixed solution obtained in the step (2), adding deionized water to a constant volume of 1L, uniformly stirring, filtering to obtain the antibacterial phosphorus-free cleaning agent, and filtering by using a cellulose nitrate filter membrane with the aperture of 0.22 um.
A Hitachi 7100 full-automatic biochemical analyzer is taken as an experimental object, and Hitachi 7100 original cleaning solution is HITERGENT original solution.
The following tests were carried out for example 1:
1. experiment of bacterial culture
3ml of solution is sucked from the reaction tank and added into a blood culture medium for culture before the biochemical analyzer is started up for three consecutive days, 0.1ml of solution is sucked from the culture medium every day and is transferred into a blood plate once, and whether bacteria grow or not is observed after the culture is carried out for three days.
And (3) testing results: after three days of culture no bacterial growth occurred.
2. Defoaming and cleaning Capacity test
Taking out the reaction cup after the power-on self-test is passed, observing whether bubbles are generated in the reaction tank, and observing whether bubbles are generated after the reaction tank is repeatedly changed with water; the old reaction cups (difference between cups is more than 800) are respectively cleaned by using HITERGENT stock solution and the antibacterial phosphorus-free cleaning agent described in the example one, and then the blank of the reaction cup is determined again.
And (3) testing results: and taking out the reaction cup after the Hitachi 7100 power-on self-test is passed, so that no bubbles are generated in the reaction tank, and after the reaction tank is repeatedly changed in water, no bubbles are generated.
The original HITERGENT solution and the antibacterial phosphorus-free cleaning agent described in the first example are respectively used for cleaning old reaction cups (the difference between cups is more than 800), the blank printing cup is printed after cleaning, the difference between cups is less than 200, and the two cleaning solutions have the same cleaning capability.
3. Optical system stability test
After starting the device, HITERGENT stock solution and the antibacterial phosphorus-free cleaning agent described in the embodiment are respectively used for changing water in the reaction tank, No. 1 cup is selected for measuring cup blanks for 20 times continuously, and the cup blank values of all wavelengths are statistically processed and compared.
The test results were as follows: comparing HITERGENT stock solutions with the antimicrobial non-phosphate cleaner of example one in terms of cup blank absorbance values at different wavelengths, it can be seen from Table 1: s is very close, CV values (all are less than 2 percent) accord with the specified range of the instrument, the precision is good, and the self-made antibacterial phosphorus-free cleaning agent has no influence on the detection result of the specimen.
TABLE 1 HITERGENT comparative results of stock solutions and antimicrobial non-phosphorus cleaners prepared in EXAMPLE I
Figure BDA0002603929460000041
Figure BDA0002603929460000051
Figure BDA0002603929460000052
Average, i.e., average of 20 cup blanks; s: standard deviation is the average of the distances of each data from the mean, i.e. 20 cup blanks from the mean
Figure BDA0002603929460000053
Average of the distances of (d); CV: the coefficient of variation represents the size of the dispersion of the blank of 20 cups, and the smaller the data, the smaller the dispersion.
Figure BDA0002603929460000054
4. EXAMPLE one test for determining the effective period of the antibacterial non-phosphate detergent
After 12 months, the pH, conductivity and osmotic pressure of the antimicrobial phosphorus-free detergent were measured and compared with the parameters at the completion of the formulation, followed by the optical system stability test.
The test results were as follows: after 12 months to the expiration date, the antibacterial phosphorus-free cleaning agent prepared in the first example is observed to be still colorless and transparent liquid without flocculent precipitates, and the pH, the osmotic pressure and the conductivity are detected to be 10.17 (10.25 at the beginning), 3.04ms/cm (3.11 ms/cm at the beginning) and 713m0sm/kg (720 m0sm/kg at the beginning); the results of the optical system stability test show (see table 2): s is very close, CV values (all are less than 2 percent) meet the specified range of the instrument, the precision is good, and the antibacterial phosphorus-free cleaning agent prepared in the embodiment I at the end of the expiration date has no influence on the detection result of the specimen.
TABLE 2 comparison of the end-of-term HITERGENT stock solutions and the antimicrobial phosphorus-free cleaners prepared in EXAMPLE I
Figure BDA0002603929460000055
Figure BDA0002603929460000061
Example 2
This embodiment is substantially the same as embodiment 1 except that: an antibacterial phosphorus-free cleaning agent, wherein each 1L of the antibacterial phosphorus-free cleaning agent contains: nonylphenol polyoxyethylene ether TX-710 ml, nonylphenol polyoxyethylene ether TX-1245 ml, monoethanolamine 17ml, boric acid 4g, ethanol 30ml, toluene-4-sodium sulfonate 2g, and the balance of deionized water.
Example 3
This embodiment is substantially the same as embodiment 1 except that: an antibacterial phosphorus-free cleaning agent, wherein each 1L of the antibacterial phosphorus-free cleaning agent contains: nonylphenol polyoxyethylene ether TX-720 ml, nonylphenol polyoxyethylene ether TX-1220 ml, monoethanolamine 10ml, boric acid 2g, ethanol 10ml, toluene-4-sodium sulfonate 1g, and the balance of deionized water.
Example 4
This embodiment is substantially the same as embodiment 1 except that: an antibacterial phosphorus-free cleaning agent, wherein each 1L of the antibacterial phosphorus-free cleaning agent contains: polyoxyethylene nonyl phenyl ether TX-713 ml, polyoxyethylene nonyl phenyl ether TX-1240 ml, monoethanolamine 12ml, boric acid 3g, ethanol 20ml, toluene-4-sodium sulfonate 1.5g, and the balance deionized water.
The above description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the invention, and any modifications, equivalents, improvements and the like that fall within the spirit and principle of the present invention are intended to be included therein.

Claims (8)

1. An antibacterial phosphorus-free cleaning agent, which is characterized in that each 1L of the antibacterial phosphorus-free cleaning agent contains: nonylphenol polyoxyethylene ether TX-710-20 ml, nonylphenol polyoxyethylene ether TX-1220-45 ml, monoethanolamine 10-17ml, boric acid 2-4g, absolute ethyl alcohol 10-30ml, toluene-4-sodium sulfonate 1-2g and the balance of deionized water.
2. The antibacterial phosphorus-free cleaning agent according to claim 1, wherein each 1L of antibacterial phosphorus-free cleaning agent comprises: nonylphenol polyoxyethylene ether TX-715ml, nonylphenol polyoxyethylene ether TX-1230 ml, monoethanolamine 14ml, boric acid 3g, absolute ethyl alcohol 20ml, toluene-4-sodium sulfonate 1.5g and the balance of deionized water.
3. A method for preparing the antibacterial phosphorus-free cleaning agent as defined in claim 1 or 2, which comprises the following steps:
(1) adding monoethanolamine into deionized water to obtain a solution A, dissolving boric acid into absolute ethyl alcohol, uniformly mixing to obtain a solution B, adding the solution B into the solution A, and uniformly stirring to obtain a premixed solution;
(2) adding toluene-4-sodium sulfonate into the premixed solution obtained in the step (1), and uniformly stirring to obtain a mixed solution;
(3) and (3) adding nonylphenol polyoxyethylene ether TX-7 and nonylphenol polyoxyethylene ether TX-12 into the mixed solution obtained in the step (2), adding deionized water to a constant volume of 1L, uniformly stirring, and filtering to obtain the antibacterial phosphorus-free cleaning agent.
4. The method according to claim 3, wherein the filtration in the step (2) is performed using a nitrocellulose filter having a pore size of 0.22 um.
5. The antibacterial phosphorus-free cleaning agent as claimed in claim 1 or 2, wherein the pH of the antibacterial phosphorus-free cleaning agent is 10-10.5.
6. The antibacterial phosphorus-free cleaning agent as claimed in claim 1 or 2, wherein the conductivity of the antibacterial phosphorus-free cleaning agent is 2-5 ms/cm.
7. The antibacterial phosphorus-free cleaning agent as claimed in claim 1 or 2, wherein the osmotic pressure of the antibacterial phosphorus-free cleaning agent is 600-800m0 sm/kg.
8. The use of the antibacterial phosphorus-free cleaning agent as defined in claim 1 or 2, which is used in a full-automatic biochemical analyzer.
CN202010732788.0A 2020-07-27 2020-07-27 Antibacterial phosphorus-free cleaning agent and preparation method and application thereof Pending CN111793528A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202010732788.0A CN111793528A (en) 2020-07-27 2020-07-27 Antibacterial phosphorus-free cleaning agent and preparation method and application thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN202010732788.0A CN111793528A (en) 2020-07-27 2020-07-27 Antibacterial phosphorus-free cleaning agent and preparation method and application thereof

Publications (1)

Publication Number Publication Date
CN111793528A true CN111793528A (en) 2020-10-20

Family

ID=72827228

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202010732788.0A Pending CN111793528A (en) 2020-07-27 2020-07-27 Antibacterial phosphorus-free cleaning agent and preparation method and application thereof

Country Status (1)

Country Link
CN (1) CN111793528A (en)

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH07292387A (en) * 1994-04-28 1995-11-07 Hitachi Ltd Cleaning agent for automatic analyzer and automatic analyzer
EP0919609A1 (en) * 1997-10-01 1999-06-02 Sysmex Corporation Hematological analyzer sampling probe cleansing composition and method
JP2003139781A (en) * 2001-11-06 2003-05-14 Jeol Ltd Washing method of analyzer
CN103773631A (en) * 2014-02-12 2014-05-07 深圳市职业病防治院 Cleaning liquid for coagulometer
CN103897909A (en) * 2012-12-28 2014-07-02 上海复星医药(集团)股份有限公司 Cleaning solution applied to automatic biochemical analyzer
CN106753845A (en) * 2016-11-30 2017-05-31 刘相东 A kind of cleaning agent for blood analyser and preparation method thereof
CN107881021A (en) * 2017-11-23 2018-04-06 中山市创艺生化工程有限公司 A kind of thermostat cleaning fluid and preparation method thereof
CN111321037A (en) * 2018-12-13 2020-06-23 苏州迈瑞科技有限公司 Cleaning solution for urine visible component analysis device and preparation method and application thereof

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH07292387A (en) * 1994-04-28 1995-11-07 Hitachi Ltd Cleaning agent for automatic analyzer and automatic analyzer
EP0919609A1 (en) * 1997-10-01 1999-06-02 Sysmex Corporation Hematological analyzer sampling probe cleansing composition and method
JP2003139781A (en) * 2001-11-06 2003-05-14 Jeol Ltd Washing method of analyzer
CN103897909A (en) * 2012-12-28 2014-07-02 上海复星医药(集团)股份有限公司 Cleaning solution applied to automatic biochemical analyzer
CN103773631A (en) * 2014-02-12 2014-05-07 深圳市职业病防治院 Cleaning liquid for coagulometer
CN106753845A (en) * 2016-11-30 2017-05-31 刘相东 A kind of cleaning agent for blood analyser and preparation method thereof
CN107881021A (en) * 2017-11-23 2018-04-06 中山市创艺生化工程有限公司 A kind of thermostat cleaning fluid and preparation method thereof
CN111321037A (en) * 2018-12-13 2020-06-23 苏州迈瑞科技有限公司 Cleaning solution for urine visible component analysis device and preparation method and application thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
蒙雨明: "日立全自动生化分析仪碱性清洗液的研制", 《临床检验杂志》 *

Similar Documents

Publication Publication Date Title
CN108770836A (en) Liquid based cell preservative fluid and its preparation method and application
CN103897909A (en) Cleaning solution applied to automatic biochemical analyzer
EP1405918B1 (en) Bacteria counting method, bacteria counting apparatus, and reagent kit for counting bacteria
CN101363011A (en) Cervical exfoliated cell preservative fluid
CN112362435A (en) Cell staining reagent and cell staining method
CN102102051A (en) Alkaline cleaning solution applied to automatic biochemical analyzer
EP0101398B1 (en) Method of concentrating and measuring unicellular organisms
EP2847570B1 (en) Reagent for clarifying emulsions and method of clarification
CN111793528A (en) Antibacterial phosphorus-free cleaning agent and preparation method and application thereof
Delamater et al. Basic fuchsin as a nuclear stain
CN111690713A (en) Eight joint inspection kit of vaginitis
CN103461320B (en) An a kind of conserving liquid such as not grade for liquid base thin layer cast-off cells
CN111321037A (en) Cleaning solution for urine visible component analysis device and preparation method and application thereof
CN109892320A (en) A kind of cell-preservation liquid and its preparation method and application
CN108004038B (en) Alkaline cleaning fluid and preparation method thereof
JPH01319407A (en) Cleansing agent for constant temperature bath
CN115372107A (en) Pretreatment reagent and preparation method, cell staining method and pretreatment method
Huppert et al. Combined methenamine-silver nitrate and hematoxylin & eosin stain for fungi in tissues
Wilson et al. Death and division of lymphocytes: neglected factors in assessment of PHA-induced transformation
CN117187003A (en) Alkaline cleaning solution suitable for full-automatic biochemical analyzer and preparation method and application thereof
Wills et al. Micro-method for the estimation of calcium by AutoAnalyser
CN116622448A (en) Cleaning liquid for automatic biochemical analyzer
CN107881021A (en) A kind of thermostat cleaning fluid and preparation method thereof
CN1034141C (en) Agar standard tube for testing liquid turbidity and its manufacture
Sobel et al. A simplified method for the determination of amylase activity in serum and urine using glycogen and the anthrone reagent

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
RJ01 Rejection of invention patent application after publication

Application publication date: 20201020

RJ01 Rejection of invention patent application after publication