CN111789122A - A kind of acaricidal composition containing fenpyroxifen and spirocyclic quaternary acid pesticides - Google Patents

Abstract

The invention discloses a composition containing pyraclostrobin nitrile and pyrethroid pesticide spirocyclic tetronic acid pesticide, wherein the weight ratio of the pyraclostrobin nitrile to the spirocyclic tetronic acid pesticide in the composition is 1-50: 50-1. The invention also provides an acaricide containing the composition. The composition and the acaricide provided by the invention are suitable for controlling mites.

Description

A kind of acaricidal composition containing fenpyroxifen and spirocyclic quaternary acid pesticides

technical field

The invention belongs to the field of pesticides, and relates to an acaricidal composition.

Background technique

Agricultural pest mites are small in size, fast in reproduction, strong in adaptability and easy to produce resistance. They are one of the most difficult pests to control. They harm the leaves, shoots, flower buds and fruits of plants. When the number of insect populations increases sharply, it will cause plant damage. Defoliation, inhibited growth or even withered.

In order to more effectively control mites and delay the resistance of plants to acaricides, it is a better way to combine acaricides with different mechanisms of action, in order to obtain better and efficient product formulations for Control of mites.

Azoxafen has the following structural formula (I), which is an acrylonitrile acaricide, which is converted into hydroxyl compounds through metabolism, and then acts on the electron transport chain of the respiratory system, disrupts the function of succinate dehydrogenase, and inhibits mitochondrial It has normal efficacy to achieve the purpose of prevention and control, and has high biological activity on adult mites, nymphs and eggs.

Although fenfenpyr has high biological activity against adult mites, nymphs and eggs, if it is used for a long time, it is still easy to make pests resistant to it, and its control effect is getting worse and worse. In order to maintain or even improve the control effect of fenoxafen, delay the generation of drug resistance of harmful mites, and prolong the service life of the medicament, it is a better method to compound fenfenafen with other acaricides.

Therefore, it is necessary to carry out technical improvement on fenflufen-fen-fen, especially to carry out further research on the acaricide composition containing fenfenthifen.

SUMMARY OF THE INVENTION

The purpose of the present invention is to provide an acaricide composition containing fenflufenac, which has the advantages of high efficiency, low toxicity and long duration of effect, can effectively prevent and control common harmful mites in crops, and is beneficial to the comprehensive management of harmful mites .

The present invention provides a composition containing fenfenpyr and spirocyclic quaternary acid pesticides.

In the composition provided by the present invention, the components fenfenpyr and spirocyclic quaternary acid pesticides are active ingredients. The weight ratio of the active ingredient fenfenpyr and the spirocyclic quaternary acid pesticide is preferably 1-50:50-1.

It is further preferred that, in the composition, the weight ratio of the active ingredient fenfenpyr and spirocyclic quaternary acid pesticides is 1-30:30-1.

More preferably, in the composition, the weight ratio of the active ingredient fenfenpyr and spirocyclic quaternary acid pesticides is 1-10:10-1.

Most preferably, in the composition, the weight ratio of the active ingredient fenfenpyr and spirocyclic quaternary acid pesticides is 1-4:4-1.

In the composition provided by the present invention, the active ingredient spirocyclic quaternary acid pesticides can be spirocyclic quaternary acid pesticides commonly used in the art.

As a preferred mode, the spirocyclic quaternary acid pesticide is selected from at least one of spirodiclofen, spiromethicone, spirotetramat and spirodiclofen.

When the active ingredient spirocyclic quaternary acid pesticide is a combination of more than one spirocyclic quaternary acid pesticide, the several spirocyclic quaternary acid pesticides can be combined in any ratio.

The present invention also provides an acaricide, which contains 1-90% by weight of the above composition, and the rest are acceptable carriers and adjuvants in pesticide formulations.

As a preferred mode, the acaricide provided by the present invention contains 5-40% by weight of the above composition, and the rest are acceptable carriers and adjuvants in pesticide formulations.

For the acaricide provided by the present invention, the carrier used in the formulation of its formulation can be any carrier used in the development and production of pesticide formulations, and can be solid or liquid.

Suitable solid carriers include: minerals, plants, synthetic fillers and inorganic salts. Among them, minerals include silicates, carbonates, sulfates, oxides, plants, synthetic fillers and inorganic salts. Silicates, such as kaolin, sepiolite, nacre, montmorillonite, mica, vermiculite, pyrophyllite, talc, etc. Carbonates, such as calcium carbonate, dolomite, etc. Sulfates, such as ammonium sulfate, sodium sulfate, calcium sulfate, etc. Oxides such as quicklime, magnesia lime, diatomaceous earth, etc. Plants, such as: citrus pulp, corn cobs, rice husk meal, rice husk, soybean straw meal, tobacco powder, walnut shell, sawdust, etc. Synthetic fillers, such as precipitated calcium carbonate hydrate, precipitated calcium carbonate, silica, etc. Inorganic salts such as potassium chloride, sodium chloride.

Liquid carriers include water and organic solvents. Suitable organic solvents include aromatic hydrocarbons, chlorinated aliphatic hydrocarbons, aliphatic hydrocarbons, alcohols, ethers, ketones, specialty solvents, vegetable oils and methylated vegetable oils. Aromatic hydrocarbons such as benzene, xylene, mesitylene, toluene. Chlorinated aliphatic hydrocarbons such as chloroform, dichloromethane, chloroform, carbon tetrachloride and polychloroethane, etc. Aliphatic hydrocarbons, such as petroleum distillates, cyclohexane, light mineral oils and paraffins, etc. Alcohols such as methanol, ethanol, isopropanol, butanol, isobutanol, ethylene glycol, propylene glycol, glycerol, fatty alcohols, and the like. Ethers, such as propylene glycol ethyl ether, propylene glycol methyl ether, petroleum ether, etc. Ketones such as acetone, cyclohexanone, isophorone, N-methyl-pyrrolidone, N-octylpyrrolidone, and the like. Specialty solvents, such as dimethylformamide, dimethyl sulfoxide, polyethylene glycol, nitrile, etc.

The above-mentioned organic solvents may be used alone, may be used in combination, or may be used in combination with water.

For the acaricide provided by the present invention, the auxiliary agent used in the preparation of its dosage form can be selected from one or more of surfactants, defoaming agents, thickening agents, suspending agents and antifreezing agents as required, and can also be selected according to the requirements. Need to include other additives commonly used in the industry.

The surfactant may be one, two or three selected from emulsifiers, dispersants and wetting agents. Emulsifiers include nonionic emulsifiers and anionic emulsifiers. Non-ionic emulsifiers, preferably nonylphenol polyoxyethylene ether, fatty alcohol polyoxyethylene ether, styrylphenyl polyoxyethylene ether, alkylphenol formaldehyde resin polyoxyethylene ether, hydroxyl terminated polyoxyethylene polyoxyethylene ether Propylene ether, styryl phenol formaldehyde resin polyoxyethylene polyoxypropylene ether, castor oil polyoxyethylene ether. Anionic emulsifier, preferably calcium dodecylbenzenesulfonate, tristyryl phenol polyoxyethyl ether phosphate amine salt, nonylphenol polyoxyethylene ether phosphate amine salt, castor oil polyoxyethylene ether phosphate amine Salt.

Dispersant, can be selected from acrylic acid homopolymer sodium salt, maleic acid disodium salt, naphthalenesulfonic acid formaldehyde condensate sodium salt, rosin block polyoxyethylene ether polyoxypropylene ether sulfonate, hydroxyl terminated polyoxyethylene One or more of polyoxypropylene ether block copolymer, triphenylethylphenol polyoxyethylene ether phosphoric acid ester, fatty alcohol polyoxyethylene ether phosphoric acid and sodium p-hydroxyphenyl lignin sulfonate.

The wetting agent can be one or more selected from fatty alcohol polyoxyethylene ether, naphthalene sulfonate, sodium lauryl sulfate, and alkylphenol resin polyoxyethylene ether sulfate.

In the acaricide provided by the present invention, a thickener can be further added as required in the preparation of its dosage form.

The thickener can be one or more selected from xanthan gum, magnesium aluminum silicate, sodium alginate, sodium carboxymethyl cellulose, gum arabic, gelatin and polyvinyl alcohol.

The acaricide provided by the present invention can be formulated into a dosage form according to a method commonly used in the art.

As a preferred form, the acaricide is emulsifiable concentrate, oil suspension, suspension, suspoemulsion, wettable powder, water dispersible granule, microcapsule suspension or water emulsion.

The compositions and acaricides provided by the present invention are suitable for controlling mites.

As a preferred mode, the mites that the composition and acaricide provided by the present invention are particularly suitable for control are selected from citrus spider mites, cinnabar spider mites, apple spider mites, cotton spider mites, strawberry spider mites, and hawthorn spider mites and at least one of the yellow mites.

As a preferred mode, the compositions and acaricides provided by the present invention are suitable for controlling mites on plants.

As a more preferred way, the compositions and acaricides provided by the present invention are suitable for controlling mites on citrus, cotton, apple, and vegetables.

Compared with the prior art, the composition provided by the invention has the following advantages:

(1) The two active ingredients in the composition show excellent synergistic effect within the proportioning range, and the acaricidal effect is significantly improved compared with its single agent, and it also has the advantages of good quick effect and long lasting effect;

(2) Use two active ingredients to rationally mix the different modes of action and different mechanisms of action of the mites, which not only prolongs the service life of the pesticides, but also delays the generation of drug resistance of the mites;

(3) The dosage is reduced, and the cost of farmers' medication is reduced.

Detailed ways

The present invention will be further described below with reference to specific embodiments, but the present invention is not limited to these specific embodiments. Those skilled in the art should realize that the present invention covers all alternatives, modifications and equivalents that may be included within the scope of the claims.

In the following examples, all percentages are by weight unless otherwise specified.

1. Indoor toxicity test

The applicant conducted an indoor toxicity test on the composition containing fenfenpyr and spirocyclic quaternary acid pesticides. The test refers to the indoor bioassay test guidelines for pesticides and pesticides (agricultural industry standard NY/T1154.7-2006) and the creation of the SOP for pesticide biological activity evaluation (insecticide volume), using the dipping method.

The combined effect is calculated using the following method:

Theoretical Mixed Toxicity Index (TTI)=Toxicity Index of A×A Content in Mixed Use (%)

+B virulence index×B content in mixed use (%);

Co-toxicity coefficient: if it is greater than 120, it indicates a synergistic effect; if it is less than 80, it indicates an antagonistic effect; if it is greater than 80 and less than 120, it indicates an additive effect.

Example 1. The synergistic effect of the combination of fenfenpyr and spirodiclofen on Tetranychus cinnabarinus

Table 1, the composition of fenfenpyr and spirofenib against Tetranychus cinnabarinus

(Tetranychus Cinnabarinus) Joint Synergy

Example 2. The synergistic effect of the combination of fenfenib and spirofenafen on Tetranychus cinnabarinus

Table 2. The combination of fenfenpyr and spirofenafen against Tetranychus cinnabarinus

(Tetranychus Cinnabarinus) Joint Synergy

It can be seen from Table 1-2 that the co-toxicity coefficients of fenfenpyr and spirocyclic quaternary acid pesticides (spirofenac, spirofenac) when the mass ratio is 50:1 to 1:50 are greater than 120, showed a synergistic effect on Tetranychus cinnabarinus. It is reasonable and feasible to mix fenfenpyr and spirocyclic quaternary acid pesticides.

2. The preventive effect of dosage forms

Example 3, 40% fenpyroxifen·spirofenac suspending agent

Nitrile 20%, Spirofenac 20%, Naphthalenesulfonic acid formaldehyde condensate sodium salt 4%, Fatty alcohol polyoxyethylene ether 2%, Xanthan gum 0.15%, Silicone defoamer 0.3%, Propylene glycol 5% % The balance is the formula of deionized water, mix the components evenly, then add them to a sand mill and grind to a certain particle size, and after high-shear mixing, prepare 40% suspension of fenpyroxifen and spirodiclofen. agent.

The prepared 40% fenpyroxifen-spirofenac suspension agent was applied to control citrus red spiders. The experimental site is Beilun District, Ningbo City, Zhejiang Province. At the dose of 80 mg/kg of active ingredient of 40% fenfenib-spirotafen suspension, the control effects on citrus red spider 3 days, 14 days and 30 days after the drug were 95.7%, 97.6% and 95.8%, respectively. . At the dose of 80mg/kg of active ingredient, the control effect of control agent 20% fenpyroxifen suspension against citrus red spider 3 days, 14 days and 30 days after the drug was 90.7%, 95.8% and 91.5%, respectively. At the dose of 100 mg/kg of active ingredient, the control effect of 240 g/L spirodiclofen suspension on citrus spider mites was 50.3%, 75.6% and 68.2% respectively 3 days, 14 days and 30 days after the drug.

After the combination of fenfenpyr and spirofenafen, the synergistic effect is obvious, and the quick-acting and lasting effect are obviously better than those of the control agent.

Example 4, 25% fenpyroxifen·spirofenac suspending agent

15% fenoxafen, 10% spirodiclofen, 2% hydroxy-terminated ethylene oxide propylene oxide block polyether, 3% maleic acid homopolymer sodium salt, 0.15% xanthan gum, silicone The formula of foaming agent 0.3%, propylene glycol 5%, and the balance is deionized water. Mix the components evenly, then add them to a sand mill and grind to a certain particle size, and mix them with high shear to prepare 25% azole Ether fennitrile · spirodiclofen suspending agent.

The prepared 25% fenpyroxifen·spirofenac suspension preparation was applied to cotton spider mites. The experimental site is Anyang City, Henan Province. At the dose of 80 mg/kg of active ingredient, the control effect of 25% fenpyroxifen-spirotafen suspoemulsion against cotton spider mites was 97.2%, 99.5% and 98.8% respectively 3 days, 14 days and 30 days after the drug. . At the dose of 80 mg/kg of active ingredient, the control effect of control agent 20% fenpyroxifen suspension against cotton spider mites was 91.3%, 95.6% and 90.7% respectively 3 days, 14 days and 30 days after the drug. The control effect of the control agent 240 g/L spirodiclofen suspension was 51.3%, 73.5% and 74.7% on cotton red spider 3 days, 14 days and 30 days after the drug at the dose of 100mg/kg active ingredient.

After the combination of fenfenpyr and spirofenafen, the synergistic effect is obvious, and the quick-acting and lasting effect are obviously better than those of the control agent.

Example 5, 20% fenpyroxifen·spirofenac emulsifiable concentrate

Fill up to 100% according to 15% fenfenpyr, 5% spirodiclofen, 4% calcium dodecyl benzene sulfonate, 15% castor oil polyoxyethylene ether, 20% methyl oleate, and S-150# According to the formula, mix and stir the components until transparent, and then 20% fenfenib-spirofenac emulsifiable concentrate can be obtained.

The prepared 20% fenpyroxifen·spirofenac emulsifiable concentrate was applied to control apple spider mites. The experimental site is Yantai City, Shandong Province. At the dose of 80 mg/kg of active ingredient, the control effect of 20% fenfenib-spironafen emulsifiable concentrate on red spider mites was 95.7%, 98.3% and 97.8% respectively 3 days, 14 days and 30 days after the drug. At the dose of 80 mg/kg of active ingredient, the control effect of control agent 20% fenpyroxifen EC against red spider mites was 91.8%, 93.7% and 91.2% respectively 3 days, 14 days and 30 days after the drug. At the dose of 100 mg/kg of active ingredient of 240 g/L spirobifen EC, the control effect on red spider mites was 52.4%, 76.5% and 74.8% 3 days, 14 days and 30 days after the drug, respectively.

After the combination of fenfenpyr and spirofenafen, the synergistic effect is obvious, and the quick-acting and lasting effect are obviously better than those of the control agent.

Example 6, 35% fenfenib and spiromethicone suspending agent

20% fenfenib, 15% spiromethicone, 3.5% acrylic acid homopolymer sodium salt, 1% fatty alcohol polyoxyethylene ether, 0.15% xanthan gum, 0.3% silicone defoamer, 5% propylene glycol , the balance is the formula of deionized water, mix all components evenly, then add in a sand mill to grind to a certain particle size, and after high shear mixing, prepare 35% fenfenpyr fenpyroxifen. suspending agent.

The prepared 35% fenpyroxifen·spironafen suspending agent was applied to control citrus red spiders. The experimental site is Beilun District, Ningbo City, Zhejiang Province. At the dose of 80mg/kg of active ingredient, the control effect of 35% fenfenib-spironafen suspension against citrus red spider 3 days, 14 days and 30 days after the drug was 97.8%, 99.1% and 96.5%, respectively. %. At the dose of 80mg/kg of active ingredient, the control effect of control agent 20% fenpyroxifen suspension against citrus red spider 3 days, 14 days and 30 days after the drug was 90.7%, 95.8% and 91.5%, respectively. At the dose of 100mg/kg of active ingredient, the control effect of control agent 24% spiromethicone suspension against citrus red spider 3 days, 14 days and 30 days after the drug was 51.2%, 73.5% and 72.8%, respectively.

After the combination of fenfenpyr and spirofenafen, the synergistic effect is remarkable, and the quick-acting and lasting effect are obviously better than those of the control agent.

Example 7, 20% fenpyroxifen·spironafen emulsifiable concentrate

Fill up the formula to 100% according to the formula of fenfenpyr 10%, spiromethicone 10%, calcium dodecyl benzene sulfonate 3%, triphenylethylphenol polyoxyethylene ether 15%, S-150#, The components are mixed and stirred until transparent, and then 20% fenfenib-spironafen emulsifiable concentrate can be obtained.

The prepared 20% fenpyroxifen·spironafen emulsifiable concentrate was applied to control citrus red spiders. The experimental site is Beilun District, Ningbo City, Zhejiang Province. At the dose of 80 mg/kg of active ingredient of 20% fenfenib-spironafen emulsifiable concentrate, the control effects on citrus red spider 3 days, 14 days and 30 days after the drug were 96.7%, 98.5% and 97.3%, respectively. . At the dose of 80 mg/kg of the active ingredient of the control agent 20% fenoxafen EC, the control effects on citrus red spider 3 days, 14 days and 30 days after the drug were 90.7%, 95.8% and 91.5%, respectively. At the dose of 100 mg/kg of active ingredient 24% spiromethicone EC, the control effect on citrus spider mites was 52.3%, 74.5% and 71.2% at 3 days, 14 days and 30 days after the drug, respectively.

After the combination of fenfenpyr and spirofenafen, the synergistic effect is remarkable, and the quick-acting and lasting effect are obviously better than those of the control agent.

Example 8, 40% fenpyroxifen·spirofenac suspending agent

Nitrile 20%, Spirofenac 20%, Naphthalenesulfonic acid formaldehyde condensate sodium salt 4%, Fatty alcohol polyoxyethylene ether 2%, Xanthan gum 0.15%, Silicone defoamer 0.3%, Propylene glycol 5% %, the balance is the formula of deionized water, mix all the components evenly, then add in a sand mill and grind to a certain particle size, and after high-shear mixing, prepare 40% fenfenpyr and spirodiclofen suspending agent.

The prepared 40% fenpyroxifen·spirofenacil suspension agent was applied to control strawberry spider mites. The experimental site is Shaoxing City, Zhejiang Province. At the dose of 80 mg/kg of active ingredient of 40% fenfenib-spirotafen suspension, the control effects on citrus red spider 3 days, 14 days and 30 days after the drug were 94.8%, 96.7% and 95.0%, respectively. . At the dose of 80 mg/kg of active ingredient, the control drug 20% fenfenpyr suspension had 90.8%, 94.5%, and 92.3% control effects on red spider mites 3 days, 14 days, and 30 days after the drug, respectively. At the dose of 100 mg/kg of active ingredient of the control agent 240 g/L spirodiclofen suspension, the control effects on red spider mites were 52.5%, 73.7% and 60.8% 3 days, 14 days and 30 days after the drug, respectively.

After the combination of fenfenpyr and spirofenafen, the synergistic effect is obvious, and the quick-acting and lasting effect are obviously better than those of the control agent.

Example 9, 20% fenpyroxifen and spirodiclofen EC

Fill up to 100% according to 15% fenfenpyr, 5% spirodiclofen, 4% calcium dodecyl benzene sulfonate, 15% castor oil polyoxyethylene ether, 20% methyl oleate, and S-150# According to the formula, mix and stir the components until transparent, and then 20% fenfenib-spirofenac emulsifiable concentrate can be obtained.

The prepared 20% fenoxafen·spirofenac emulsifiable concentrate was applied to control Hawthorn spider mites. The experimental site is Tai'an City, Shandong Province. At the dose of 80 mg/kg of active ingredient, 20% fenfenib-spironafen emulsifiable concentrate had 94.8%, 98.4% and 97.1% control effects on Tetranychus hawthorn 3 days, 14 days and 30 days after the drug. At the dose of 80mg/kg of active ingredient, the control effect of control agent 20% fenpyroxifen EC against Tetranychus hawthorn was 90.9%, 94.0% and 91.5% respectively 3 days, 14 days and 30 days after the drug. At the dose of 100 mg/kg of active ingredient of 240 g/L spirodiclofen EC, the control effect on Tetranychus hawthorn was 58.2%, 73.5% and 70.8% 3 days, 14 days and 30 days after the drug, respectively.

After the combination of fenfenpyr and spirofenafen, the synergistic effect is obvious, and the quick-acting and lasting effect are obviously better than those of the control agent.

Example 10, 35% fenfenib-spironafen suspending agent

20% fenfenib, 15% spiromethicone, 3.5% acrylic acid homopolymer sodium salt, 1% fatty alcohol polyoxyethylene ether, 0.15% xanthan gum, 0.3% silicone defoamer, 5% propylene glycol , the balance is the formula of deionized water, mix all components evenly, then add in a sand mill and grind to a certain particle size, and after high shear mixing, prepare 35% fenfenpyr fenpyroxifen suspending agent.

The prepared 35% fenpyroxifen·spiromethicone suspension agent was applied to control the yellow mites of tea tree. The experimental site is Hangzhou City, Zhejiang Province. At the dose of 80 mg/kg of active ingredient, 35% fenfenib-spironafen suspending agent, the control effect of 3 days, 14 days, and 30 days after the drug on the yellow mites of tea tree was 96.8%, 98.5%, 98.5%, 96.1%. At the dose of 80 mg/kg of the active ingredient of the control agent 20% fenfenpyr suspension, the control effects of 3 days, 14 days and 30 days after the drug were 91.2%, 94.9% and 91.1% respectively. At the dose of 100mg/kg of active ingredient, the control effect of control agent 24% spiromethicone suspension against Camellia sinensis was 55.6%, 75.3% and 73.1% respectively 3 days, 14 days and 30 days after the drug.

After the combination of fenfenpyr and spirofenafen, the synergistic effect is remarkable, and the quick-acting and lasting effect are obviously better than those of the control agent.

Claims (10)

1. a composition, it is characterized in that: described composition contains fenfenpyr and spirocyclic quaternary acid pesticides, and fenfenfen and spirocyclic quaternary acid pesticides The weight ratio is 1～50:50～1. 2. The composition according to claim 1, wherein the composition contains fenfenpyr and spirocyclic quaternary acid pesticides, and fenfenac and spiroquaternary The weight ratio of the ketoacid pesticide spirocyclic quaternary ketoacid pesticide is 1-30:30-1. 3. The composition according to claim 2, wherein the composition contains fenfenpyr and spirocyclic quaternary acid pesticides, and fenfenac and spiroquaternary The weight ratio of the ketoacid pesticide spirocyclic quaternary ketoacid pesticide is 1-10:10-1. 4. The composition according to claim 3, characterized in that: the composition contains fenfenpyr and spirocyclic quaternary acid pesticides, and the weight ratio of fenfenfen and spirocyclic quaternary acid pesticides is It is 1～4:4～1. 5. The composition according to claim 1, wherein the spirocyclic quaternary ketoacid pesticide is selected from at least one of spirodiclofen, spirodiclofen, spirotetramat and spirodiclofen. 6. An acaricide, characterized in that: the acaricide contains 1-90% by weight of the composition according to claim 1, and the rest are acceptable carriers and adjuvants in pesticide formulations. 7. according to the described acaricide of claim 6, it is characterized in that: The acaricide contains 5-40% by weight of the composition according to claim 1, and the rest are acceptable carriers and adjuvants in pesticide formulations. 8. The acaricide according to claim 6, wherein the acaricide is emulsifiable concentrate, oil suspension, suspending agent, suspoemulsion, wettable powder, water dispersible granule, microcapsule suspending agent or water Emulsion. 9. Use of a composition according to claim 1, characterized in that the composition is used for controlling mites. 10. The application of the composition according to claim 9, wherein the mites that the composition is used for control are selected from citrus spider mites, cinnabar spider mite, apple spider mites, cotton spider mites, strawberry spider mites, hawthorn At least one of spider mites and tea yellow mites.