CN111494218A - Bioactive glass - Google Patents
Bioactive glass Download PDFInfo
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- CN111494218A CN111494218A CN202010036388.6A CN202010036388A CN111494218A CN 111494218 A CN111494218 A CN 111494218A CN 202010036388 A CN202010036388 A CN 202010036388A CN 111494218 A CN111494218 A CN 111494218A
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- bioactive glass
- glass
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- temperature
- bioactive
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- 239000005313 bioactive glass Substances 0.000 title claims abstract description 135
- 229910001634 calcium fluoride Inorganic materials 0.000 claims abstract description 10
- 238000000034 method Methods 0.000 claims description 47
- 239000000203 mixture Substances 0.000 claims description 35
- 210000005239 tubule Anatomy 0.000 claims description 17
- 208000002925 dental caries Diseases 0.000 claims description 16
- 239000002245 particle Substances 0.000 claims description 16
- 239000007788 liquid Substances 0.000 claims description 13
- 238000001035 drying Methods 0.000 claims description 11
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 11
- 210000000988 bone and bone Anatomy 0.000 claims description 9
- 239000006060 molten glass Substances 0.000 claims description 9
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical group CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 8
- 206010020751 Hypersensitivity Diseases 0.000 claims description 8
- 238000002156 mixing Methods 0.000 claims description 8
- 208000026935 allergic disease Diseases 0.000 claims description 7
- 238000000498 ball milling Methods 0.000 claims description 7
- 239000003795 chemical substances by application Substances 0.000 claims description 7
- 210000003298 dental enamel Anatomy 0.000 claims description 7
- 239000002994 raw material Substances 0.000 claims description 7
- 238000007873 sieving Methods 0.000 claims description 7
- 239000000499 gel Substances 0.000 claims description 6
- 239000000843 powder Substances 0.000 claims description 6
- 238000010791 quenching Methods 0.000 claims description 6
- 239000002671 adjuvant Substances 0.000 claims description 5
- 238000005303 weighing Methods 0.000 claims description 5
- 230000003239 periodontal effect Effects 0.000 claims description 4
- 230000002265 prevention Effects 0.000 claims description 4
- 230000008439 repair process Effects 0.000 claims description 4
- 239000000606 toothpaste Substances 0.000 claims description 4
- 208000006558 Dental Calculus Diseases 0.000 claims description 3
- 210000003074 dental pulp Anatomy 0.000 claims description 3
- 238000011049 filling Methods 0.000 claims description 3
- 230000009610 hypersensitivity Effects 0.000 claims description 3
- 239000006210 lotion Substances 0.000 claims description 3
- 239000002324 mouth wash Substances 0.000 claims description 3
- 239000002674 ointment Substances 0.000 claims description 3
- 239000006072 paste Substances 0.000 claims description 3
- 238000002360 preparation method Methods 0.000 claims description 3
- 238000001356 surgical procedure Methods 0.000 claims description 3
- 239000003242 anti bacterial agent Substances 0.000 claims description 2
- 235000015218 chewing gum Nutrition 0.000 claims description 2
- 239000006071 cream Substances 0.000 claims description 2
- 239000000551 dentifrice Substances 0.000 claims description 2
- 239000003937 drug carrier Substances 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 230000000171 quenching effect Effects 0.000 claims description 2
- 229940034610 toothpaste Drugs 0.000 claims description 2
- 229940112822 chewing gum Drugs 0.000 claims 1
- 229940051866 mouthwash Drugs 0.000 claims 1
- 239000011521 glass Substances 0.000 abstract description 32
- 229910052588 hydroxylapatite Inorganic materials 0.000 abstract description 32
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 abstract description 31
- 239000000463 material Substances 0.000 abstract description 5
- 230000033558 biomineral tissue development Effects 0.000 abstract description 4
- WUKWITHWXAAZEY-UHFFFAOYSA-L calcium difluoride Chemical compound [F-].[F-].[Ca+2] WUKWITHWXAAZEY-UHFFFAOYSA-L 0.000 abstract description 3
- FUJCRWPEOMXPAD-UHFFFAOYSA-N lithium oxide Chemical compound [Li+].[Li+].[O-2] FUJCRWPEOMXPAD-UHFFFAOYSA-N 0.000 abstract description 2
- 229910001947 lithium oxide Inorganic materials 0.000 abstract description 2
- 238000010438 heat treatment Methods 0.000 description 20
- 239000012890 simulated body fluid Substances 0.000 description 20
- 230000000694 effects Effects 0.000 description 15
- 238000002441 X-ray diffraction Methods 0.000 description 13
- 230000000052 comparative effect Effects 0.000 description 13
- 238000002425 crystallisation Methods 0.000 description 11
- 230000008025 crystallization Effects 0.000 description 11
- 238000012360 testing method Methods 0.000 description 9
- 230000009286 beneficial effect Effects 0.000 description 7
- 229910052593 corundum Inorganic materials 0.000 description 7
- 239000010431 corundum Substances 0.000 description 7
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 6
- 230000003266 anti-allergic effect Effects 0.000 description 6
- QVQLCTNNEUAWMS-UHFFFAOYSA-N barium oxide Chemical compound [Ba]=O QVQLCTNNEUAWMS-UHFFFAOYSA-N 0.000 description 6
- 210000004268 dentin Anatomy 0.000 description 6
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 5
- 230000001680 brushing effect Effects 0.000 description 5
- 239000013078 crystal Substances 0.000 description 5
- 201000002170 dentin sensitivity Diseases 0.000 description 5
- 239000000395 magnesium oxide Substances 0.000 description 5
- CPLXHLVBOLITMK-UHFFFAOYSA-N magnesium oxide Inorganic materials [Mg]=O CPLXHLVBOLITMK-UHFFFAOYSA-N 0.000 description 5
- AXZKOIWUVFPNLO-UHFFFAOYSA-N magnesium;oxygen(2-) Chemical compound [O-2].[Mg+2] AXZKOIWUVFPNLO-UHFFFAOYSA-N 0.000 description 5
- 239000004570 mortar (masonry) Substances 0.000 description 5
- 230000007815 allergy Effects 0.000 description 4
- 239000005312 bioglass Substances 0.000 description 4
- 230000015572 biosynthetic process Effects 0.000 description 4
- 239000010839 body fluid Substances 0.000 description 4
- 210000001124 body fluid Anatomy 0.000 description 4
- 239000011734 sodium Substances 0.000 description 4
- 239000000243 solution Substances 0.000 description 4
- 208000024891 symptom Diseases 0.000 description 4
- DLYUQMMRRRQYAE-UHFFFAOYSA-N tetraphosphorus decaoxide Chemical compound O1P(O2)(=O)OP3(=O)OP1(=O)OP2(=O)O3 DLYUQMMRRRQYAE-UHFFFAOYSA-N 0.000 description 4
- 210000001519 tissue Anatomy 0.000 description 4
- 230000036347 tooth sensitivity Effects 0.000 description 4
- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 description 3
- 229910001424 calcium ion Inorganic materials 0.000 description 3
- BRPQOXSCLDDYGP-UHFFFAOYSA-N calcium oxide Chemical compound [O-2].[Ca+2] BRPQOXSCLDDYGP-UHFFFAOYSA-N 0.000 description 3
- 239000000292 calcium oxide Substances 0.000 description 3
- ODINCKMPIJJUCX-UHFFFAOYSA-N calcium oxide Inorganic materials [Ca]=O ODINCKMPIJJUCX-UHFFFAOYSA-N 0.000 description 3
- 230000008859 change Effects 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 150000001875 compounds Chemical class 0.000 description 3
- 230000008021 deposition Effects 0.000 description 3
- 238000001914 filtration Methods 0.000 description 3
- 239000008187 granular material Substances 0.000 description 3
- 238000000227 grinding Methods 0.000 description 3
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 3
- 230000000395 remineralizing effect Effects 0.000 description 3
- 239000000377 silicon dioxide Substances 0.000 description 3
- HBBGRARXTFLTSG-UHFFFAOYSA-N Lithium ion Chemical compound [Li+] HBBGRARXTFLTSG-UHFFFAOYSA-N 0.000 description 2
- KKCBUQHMOMHUOY-UHFFFAOYSA-N Na2O Inorganic materials [O-2].[Na+].[Na+] KKCBUQHMOMHUOY-UHFFFAOYSA-N 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 229910052586 apatite Inorganic materials 0.000 description 2
- 239000007864 aqueous solution Substances 0.000 description 2
- AYJRCSIUFZENHW-UHFFFAOYSA-L barium carbonate Inorganic materials [Ba+2].[O-]C([O-])=O AYJRCSIUFZENHW-UHFFFAOYSA-L 0.000 description 2
- XDFCIPNJCBUZJN-UHFFFAOYSA-N barium(2+) Chemical compound [Ba+2] XDFCIPNJCBUZJN-UHFFFAOYSA-N 0.000 description 2
- 230000000975 bioactive effect Effects 0.000 description 2
- 239000011575 calcium Substances 0.000 description 2
- 239000001506 calcium phosphate Substances 0.000 description 2
- 229910000389 calcium phosphate Inorganic materials 0.000 description 2
- 235000011010 calcium phosphates Nutrition 0.000 description 2
- 239000003153 chemical reaction reagent Substances 0.000 description 2
- 229910052681 coesite Inorganic materials 0.000 description 2
- 230000007797 corrosion Effects 0.000 description 2
- 238000005260 corrosion Methods 0.000 description 2
- 229910052906 cristobalite Inorganic materials 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- 238000004031 devitrification Methods 0.000 description 2
- 238000009826 distribution Methods 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 238000007496 glass forming Methods 0.000 description 2
- 230000002045 lasting effect Effects 0.000 description 2
- 229910001416 lithium ion Inorganic materials 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- VSIIXMUUUJUKCM-UHFFFAOYSA-D pentacalcium;fluoride;triphosphate Chemical compound [F-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O VSIIXMUUUJUKCM-UHFFFAOYSA-D 0.000 description 2
- 208000028169 periodontal disease Diseases 0.000 description 2
- 238000005498 polishing Methods 0.000 description 2
- 238000000634 powder X-ray diffraction Methods 0.000 description 2
- 238000001878 scanning electron micrograph Methods 0.000 description 2
- 239000000565 sealant Substances 0.000 description 2
- 238000007789 sealing Methods 0.000 description 2
- 229910052682 stishovite Inorganic materials 0.000 description 2
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 2
- 229910052905 tridymite Inorganic materials 0.000 description 2
- 206010002198 Anaphylactic reaction Diseases 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 1
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 1
- 206010061363 Skeletal injury Diseases 0.000 description 1
- FKNQFGJONOIPTF-UHFFFAOYSA-N Sodium cation Chemical compound [Na+] FKNQFGJONOIPTF-UHFFFAOYSA-N 0.000 description 1
- 230000036783 anaphylactic response Effects 0.000 description 1
- 208000003455 anaphylaxis Diseases 0.000 description 1
- 239000004599 antimicrobial Substances 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 229910052788 barium Inorganic materials 0.000 description 1
- DSAJWYNOEDNPEQ-UHFFFAOYSA-N barium atom Chemical compound [Ba] DSAJWYNOEDNPEQ-UHFFFAOYSA-N 0.000 description 1
- 239000006121 base glass Substances 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- VTYYLEPIZMXCLO-UHFFFAOYSA-L calcium carbonate Substances [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 1
- 229910000019 calcium carbonate Inorganic materials 0.000 description 1
- 210000000845 cartilage Anatomy 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 210000002808 connective tissue Anatomy 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 238000012258 culturing Methods 0.000 description 1
- 238000005520 cutting process Methods 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 230000003628 erosive effect Effects 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 230000036571 hydration Effects 0.000 description 1
- 238000006703 hydration reaction Methods 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000005342 ion exchange Methods 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- 239000011777 magnesium Substances 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- 239000003607 modifier Substances 0.000 description 1
- 210000000214 mouth Anatomy 0.000 description 1
- 230000010355 oscillation Effects 0.000 description 1
- 239000011574 phosphorus Substances 0.000 description 1
- 229910052698 phosphorus Inorganic materials 0.000 description 1
- 230000004962 physiological condition Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000009257 reactivity Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 239000010703 silicon Substances 0.000 description 1
- 229910052710 silicon Inorganic materials 0.000 description 1
- 229910001415 sodium ion Inorganic materials 0.000 description 1
- 229910001948 sodium oxide Inorganic materials 0.000 description 1
- 210000004872 soft tissue Anatomy 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000029663 wound healing Effects 0.000 description 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/20—Halogens; Compounds thereof
- A61K8/21—Fluorides; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/24—Phosphorous; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/25—Silicon; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/02—Inorganic materials
- A61L27/025—Other specific inorganic materials not covered by A61L27/04 - A61L27/12
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/02—Inorganic materials
- A61L27/10—Ceramics or glasses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/02—Inorganic materials
- A61L27/12—Phosphorus-containing materials, e.g. apatite
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/60—Materials for use in artificial skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/04—Materials or treatment for tissue regeneration for mammary reconstruction
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
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- A—HUMAN NECESSITIES
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- A61L2430/00—Materials or treatment for tissue regeneration
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- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
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- Medicinal Chemistry (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Dermatology (AREA)
- Birds (AREA)
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- Ceramic Engineering (AREA)
- Pharmacology & Pharmacy (AREA)
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- Cosmetics (AREA)
Abstract
The invention relates to bioactive glass, and belongs to the field of materials. Compared with basic glass, the glass also contains a certain amount of lithium oxide and calcium fluoride, has high mineralization speed, can quickly form hydroxyapatite, has good bioactivity, and can be used for teeth and the like.
Description
Technical Field
The invention relates to bioactive glass, and belongs to the field of materials.
Background
The bioactive glass is developed by the professor Hench of the university of Florida in 1969, besides a 45S5 bioactive glass formula developed by the professor Hench, various bioactive glasses are continuously developed, and although the mechanical property, the biocompatibility and the like of the novel bioactive glass are improved to a certain extent, the 45S5 bioactive glass formula is still a well-known formula with better bioactivity.
The bioactive glass is a glass with a special composition structure, and the special composition and structure endow the bioactive glass with good bioactivity, and can be used as a bioactive material for repairing teeth, bones, skin and the like of a human body. The bioactivity of bioactive glass is the result of a complex series of physiochemical reactions on the glass surface under physiological conditions. When the bioactive glass is applied to a human body, the bioactive glass can perform close ion exchange with human body fluid, and finally a hydroxyapatite layer similar to the components of teeth, bones, skin and the like is formed. At present, bioactive glass has been successfully applied to the fields of treatment and repair of bone injury and periodontal defect. In recent years, the treatment of tooth sensitivity using bioactive glasses of calcium, phosphorus, silicon components has become a focus of research. The bioactive glass is coated on the exposed dentinal tubules, a apatite layer is gradually adhered on the dentinal tubules, and apatite crystals are formed in the tubules, so that the exposed dentinal tubules are sealed, and dentin anaphylaxis is effectively improved.
Although the 45S5 bioactive glass has a certain mineralization and antiallergic effects, the mineralization time is long, namely the onset is slow, and the problem of dentin hypersensitivity cannot be solved quickly and effectively. Therefore, there is a need to further improve the bioactivity of bioactive glass in order to obtain bioactive glass with high speed, lasting effect, and capability of preventing, relieving and/or radically treating various symptoms including tooth allergy.
Disclosure of Invention
The invention provides the bioactive glass with better bioactivity on the basis of 45S5 bioactive glass. When the bioactive glass provided by the invention is applied, hydroxyapatite can be quickly formed, the bioactive glass is used for oral teeth, can quickly seal dentinal tubules, prevent, relieve and/or radically cure tooth allergy symptoms, has an obvious anti-sensitivity effect, and has the functions of preventing oral caries, repairing damaged enamel and the like.
The bioactive glass of the present invention can form a Hydroxyapatite (HCA) layer in vitro when placed in Simulated Body Fluid (SBF). The formation of hydroxyapatite begins with the bioactive glass being in contact with a simulated body fluid. In the context of the present invention, a bioactive glass is considered bioactive if it forms a HCA crystalline layer within 24 hours when exposed to a Simulated Body Fluid (SBF).
The bioactive glass provided by the invention comprises the following components in percentage by mass (wt.%):
the bioactive glass provided by the invention contains L i2O (lithium oxide) with a lithium ion radius much smaller than that of sodium ion, so that the glass structure is more porous by adding lithium ions, and in the present invention, L i is added in an amount of 0.5 to 2.5% by mass of the oxide2O can loosen the glass structure, the glass network is easy to disintegrate, the glass activity is higher, simultaneously the glass forming performance of the glass is not influenced, and the antiallergic speed and the antiallergic effect of the activated glass are favorably improved.
The bioactive glass provided by the invention contains proper CaF2(calcium fluoride), proper amount is 2.0-9.0% (by mass of oxide), and proper amount of CaF2Is favorable for improving the speed of forming hydroxyapatite in the human body fluid environment by the bioactive glass and improving the anti-allergic speed and effect of the bioactive glass.
Proper amount of CaF2And an appropriate amount of L i2O is beneficial to improving the speed of forming hydroxyapatite in the human body fluid environment by bioactive glass and simultaneously can also give consideration to the glass forming performance. The inventors have found that CaF is present in bioactive glasses on an oxide basis25.55 to 7.66 percent of L i20.84 to 1.25 percent of O, L i2O and CaF2When the mass ratio is 0.11 to 0.16, the activity of the glass to the bioactive glass is remarkably improved.
The addition of barium element to the glass can lead to the generation of a part of Ca in the hydroxyapatite2+Is displaced to thereby generate mixed Ba2+/Ca2+Hydroxyapatite due to Ba2+The substituted hydroxyapatite has lower solubility than the unsubstituted hydroxyapatite, so that the deposition rate of the generated hydroxyapatite is increased and the glass is shown to be more activeIs strong. The bioactive glass provided by the invention contains a proper amount of BaO (barium oxide), the proper amount is 1.0-3.0% (by mass of the oxide), and the proper amount of BaO is beneficial to improving the speed of forming hydroxyapatite in a human body fluid environment and improving the acid corrosion resistance of the glass, so that the anti-allergic speed of the bioactive glass is improved, and the effect is more durable.
Magnesium exists in glass as a network modifier, and the addition of the bioactive glass can distort the glass structure, destroy the original structure of the bioactive glass, enable the glass to have a faster ion release rate and improve the activity. The bioactive glass provided by the invention contains a proper amount of MgO (magnesium oxide), the proper amount is 1.0-3.0% (by mass of oxides), and the proper amount of MgO is beneficial to improving the acid corrosion resistance of the bioactive glass, so that the anti-allergic speed of the bioactive glass is improved, and the effect is more durable.
The bioactive glass provided by the invention also contains SiO in terms of mass of oxides2(silica), P2O5(phosphorus pentoxide), Na2O (sodium oxide), and CaO (calcium oxide).
SiO2Form an amorphous network of bioactive glass, and SiO2The percentage of (c) affects its network connectivity. The bioactive glass provided by the invention contains SiO in terms of mass of oxides235.0 to 40.0 percent of the total weight of the glass, and is matched with other components, thereby being beneficial to improving the activity of the bioactive glass.
The release of phosphate ions from the surface of the bioactive glass aids in the formation of hydroxyapatite. While hydroxyapatite may be formed without the bioactive glass providing phosphate ions, the bioactive glass providing phosphate ions may increase the rate of hydroxyapatite formation. The bioactive glass provided by the invention contains P in terms of oxide mass2O58.0 to 11.0 percent and is matched with other components, which is beneficial to improving the activity of the bioactive glass.
The release of calcium ions from the surface of the bioactive glass helps to form a calcium phosphate rich layer on the surface of the glass. The bioactive glass provides calcium ions to increase the rate of formation of the calcium phosphate-rich layer. The bioactive glass provided by the invention contains 18.0-22.0% of CaO by mass of oxides, and is matched with other components, so that the bioactive glass is beneficial to improving the activity of the bioactive glass.
The bioactive glass provided by the invention contains Na in terms of oxide mass218.0 to 22.0 percent of O, and is matched with other components, which is beneficial to improving the activity of the bioactive glass.
The bioactive glass provided by the invention can be used for remineralization of tooth structures, as a dentin sealant, remineralization of enamel, remineralization of incipient caries, remineralization of carious dentin, prevention of caries, repair of erosion, as a sealant for holes and cracks, and the like; it may also be included in toothpastes, mouthwashes, gels, restorative materials, and the like, or used to reduce dentinal sensitivity, and/or enhance tissue engagement, and the like.
The bioactive glass provided by the present invention can be incorporated into toothpastes, mouthwashes, dentifrices, chewing gums, gels, and the like for use in the oral cavity. The bioactive glass provided by the invention can be used as a material or a preparation or a composition for repairing bones or skin and is used for repairing bones or skin.
The bioactive glass provided by the invention can be applied topically, such as prepared into emulsion, lotion, ointment, powder, gel or paste for application to teeth or skin; such as a toothpaste that can be prepared to contain bioactive glass for application to the teeth of a patient suffering from tooth decay, periodontal disease, sensitive teeth, and the like; it can be used for treating periodontal disease, for preventing and/or treating dental caries; it also increases the rate of hydroxyapatite deposition, allowing occlusion of the surface of dentinal tubules for treatment of tooth sensitivity.
The bioactive glass of the present invention can be formulated and formed into compositions with other necessary adjuvants for use in various formulations or applications as described above. The adjuvant may be any component other than the bioactive glass, including without limitation components added to prepare the composition into a form suitable for use, components to make the composition more stable over time, and the like.
The bioactive glass of the present invention, or compositions comprising the bioactive glass, may further comprise one or more antimicrobial agents, one or more tartar control agents, and one or more structure-building agents.
In the composition, the bioactive glass may be present in an amount of 0.1% to 50.0% based on the total mass of the composition. In some embodiments, the bioactive glass is present in the composition in an amount of 1.0% to 20.0% based on the total mass of the composition. In some embodiments, the bioactive glass is present in the composition in an amount of 1.0% to 10.0% based on the total mass of the composition. The adjuvants may include fillers, lubricants, and/or binders, among others.
In some embodiments, a composition comprising the aforementioned bioactive glass and an adjuvant, further comprising an antibacterial agent, a tartar control agent, a structure building agent, or a combination thereof; the bioactive glass is present in an amount of 0.1% to 50.0% based on the total mass of the composition; the composition is in the form of a cream, lotion, ointment, powder, gel or paste.
The bioactive glass of the present invention or a composition comprising the bioactive glass of the present invention can be used in a method for preventing or treating dental hypersensitivity, a method for partially or fully occluding dentinal tubules, a method for preventing incipient caries, a method for preventing or treating dental caries, a method for remineralizing incipient caries, a method for remineralizing enamel, a method for occluding cracks in a tooth structure, a method for occluding points spaces in a tooth structure, a method for backing a tooth structure, a method for covering dental pulp, or/and a method for treating a tooth structure after periodontal surgery. In some embodiments, the bioactive glass of the present invention or a composition comprising the bioactive glass of the present invention can be used in a method for preventing or treating tooth sensitivity, a method for partially or fully occluding dentinal tubules, a method for incipient caries remineralization, a method for occluding cracks in a tooth structure, or a method for occluding point spaces in a tooth structure. In some embodiments, the bioactive glass of the present invention, or a composition comprising the bioactive glass of the present invention, can be used in a method for partially or fully occluding dentinal tubules, in a method for occluding cracks in a tooth structure, or in a method for occluding point spaces in a tooth structure.
The bioactive glass of the invention or the composition comprising the bioactive glass of the invention can be used in fields including, but not limited to, dental restoration, bone restoration, skin restoration, and/or as a pharmaceutical carrier.
A method of preventing or treating dental caries comprising contacting a tooth structure with an effective amount of a bioactive glass. A method of preventing incipient caries comprising contacting a tooth structure with an effective amount of a bioactive glass. A method of treating tooth sensitivity comprising contacting one or more hypersensitive teeth with an effective amount of the bioactive glass. A method of partially or fully occluding a dentin tubule comprising contacting the tubule with an effective amount of bioactive glass. A method of remineralizing enamel comprising contacting a tooth structure with an effective amount of a bioactive glass. A method of incipient caries remineralization comprising contacting a tooth structure with an effective amount of a bioactive glass. A method of sealing a fissure in a tooth structure comprising contacting the tooth structure with an effective amount of a bioactive glass. A method of closing a spot gap in a dental structure comprising contacting the dental structure with an effective amount of a bioactive glass. A method of backing a dental structure comprising contacting the dental structure with an effective amount of a bioactive glass. A method of covering dental pulp comprising contacting a tooth structure with an effective amount of a bioactive glass. A method of treating a tooth structure following periodontal surgery comprising contacting the tooth structure with an effective amount of a bioactive glass. A method of repairing bone or skin comprising contacting the bone or skin to be repaired with an effective amount of a bioactive glass.
The bioactive glass provided by the invention can be mineralized more quickly, and can better prevent, relieve and/or radically cure symptoms such as tooth allergy, decayed tooth and the like when being applied to teeth. The bioactive glass has enhanced bioactivity, the hydroxyapatite deposition speed is accelerated, the wound healing speed is accelerated, the mineralization speed is faster than that of 45S5, the hydroxyapatite can be quickly formed, and the effects of quickly sealing dentinal tubules, relieving/radically treating tooth allergy symptoms and the like are achieved.
Remineralization refers to any agent capable of forming hydroxyapatite.
The term "dental structure" refers to all parts of a tooth including, but not limited to, enamel, dentin, medulla, root structures, cementum, root matter, coronal matter, all dental articles of manufacture, and the like.
For the purposes of the present invention, the tissue may be bone tissue, cartilage, soft tissue including connective tissue and dental tissue including calcified dental tissue such as enamel and dentin.
The bioactive glass of the invention can be prepared according to the following method, which comprises the following steps:
1) weighing the raw materials of each component according to the formula proportion, uniformly mixing, and filling into a crucible;
2) placing the crucible in an electric furnace, setting the temperature rise speed of the electric furnace to be between 0.5 and 1.5h, raising the temperature to between 400 and 450 ℃, then raising the temperature to between 900 and 950 ℃ within 0.5 to 1.5h, then raising the temperature to between 1300 and 1400 ℃ within 1.5 to 2.5h, and finally preserving the temperature at between 1300 and 1400 ℃ for 1 to 4h to melt and clarify the glass liquid to obtain molten glass liquid;
3) water quenching the molten glass liquid to obtain bioactive glass; optionally comprising
4) And drying the obtained bioactive glass in an oven at 100-120 ℃ for 4-8 h, performing ball milling for 2-8 h (the medium is absolute ethyl alcohol, the rotating speed is 150-500 r/min) by using a planetary ball mill, sieving by using a standard sieve of 400-600 meshes, and drying at 100-120 ℃ for 2-6 h to obtain the bioactive glass.
In some embodiments, the bioactive glass of the present invention can be prepared according to a method comprising the steps of:
1) weighing raw materials of each component according to a formula ratio, uniformly mixing in a mortar, and filling into a corundum crucible;
2) placing the crucible in a high-temperature electric furnace at room temperature, setting the heating speed of the electric furnace to 1h, heating to 400-450 ℃, then setting the heating speed to 1h, heating to 900-950 ℃, slowly heating to 1300-1400 ℃ in 2h to fully decompose and melt the component raw materials, and finally preserving heat at 1300-1400 ℃ for 2h to melt and clarify the glass liquid to obtain molten glass liquid;
3) directly water-quenching the molten glass liquid to obtain bioactive glass; optionally comprising
4) And drying the obtained bioactive glass particles in a 110 ℃ oven for 6h, ball-milling by using a planetary ball mill (the medium is absolute ethyl alcohol, the rotating speed is 300r/min), sieving by using a 500-mesh standard sieve, and drying at 110 ℃ for 4h to obtain the bioactive glass.
The method for preparing the bioactive glass is easy to control and implement, and a product meeting the requirements can be obtained.
Drawings
FIG. 1 is an XRD (X-ray powder diffraction) pattern of a bioactive glass powder sample after being cultured in a simulated body fluid for 24h, wherein the characteristic peak intensity is changed from high to low, and the XRD pattern and the standard pattern of hydroxyapatite are respectively shown in the detection patterns of example 2, example 3 and comparative example 1.
FIG. 2 is an SEM (scanning electron microscope) picture of the surface of a human tooth sample cultured in a simulated body fluid for 3d, 7d and 14d after simulated tooth brushing in a pure water solution of bioactive glass of example 2 at a concentration of 1%.
FIG. 3 is an SEM image of the surface of a human tooth sample incubated for 3d, 7d and 14d in a simulated body fluid after simulated brushing with a 1% concentration pure water solution of bioactive glass of example 3.
FIG. 4 is an SEM photograph of the surface of a human tooth sample incubated for 3d, 7d and 14d in a simulated body fluid after simulated brushing of the teeth with a 1% concentration pure water solution of bioactive glass of comparative example 1.
FIG. 5 is SEM pictures of the surface of samples of human teeth cultured in simulated body fluid for 3d, 7d and 14 d.
Detailed Description
Embodiments of the invention, examples of which are shown in the table, are described in detail below. The embodiments described below by referring to the tables are exemplary and intended to illustrate the present invention, but are not to be construed as limiting the present invention.
Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. All patents and publications referred to herein are incorporated by reference in their entirety. The term "comprising" or "comprises" is open-ended, i.e. comprising what is specified in the present invention, but not excluding other aspects. In the present invention, all numbers disclosed herein are approximate values, regardless of whether the word "about" or "approximately" is used. The numerical values of each number may vary by as much as ± 10% or less or as reasonably understood by one of ordinary skill in the art, such as 1%, 2%, 3%, 4%, or 5%.
The examples, where specific techniques or conditions are not indicated, are to be construed according to the techniques or conditions described in the literature in the art or according to the product specifications. The reagents or instruments used are not indicated by the manufacturer, and are all conventional products available commercially.
In the examples described below, all temperatures are given in degrees Celsius unless otherwise indicated. The reagents used are either commercially available or can be prepared by the methods described herein.
The following acronyms are used throughout the invention: wt.% represents mass percent; DEG C for centigrade, SEM for scanning electron microscope, XRD for X-ray powder diffraction, μm for micrometers, ml for milliliters, r/min for revolutions per minute;
when referring to time, d represents day, h represents hour, min represents minute, and s represents second.
In the invention, the room temperature refers to the ambient temperature and can be 0-45 ℃. In some embodiments, the room temperature is from 10 ℃ to 30 ℃. In some embodiments, the room temperature is 20 ℃ to 35 ℃. In some embodiments, the room temperature is 20 ℃ to 30 ℃.
In the following examples, pure water used therein was boiled.
Example 1: testing of crystallization amount:
weighing 0.2g of active glass powder, adding the active glass powder into 100ml of Simulated Body Fluid (SBF), placing the mixture in a constant-temperature shaking table at 37 ℃, starting a reciprocating mode, rotating at 120r/min, taking out the mixture after 24 hours, filtering, cleaning, drying, uniformly mixing, and testing the percentage content of crystals in the mixture by XRD.
Simulated body fluid composition is as follows:
preparing simulated body fluid: prepared according to ISO/TR 10271 standard, and the pH is adjusted to 7.0 by NaOH (sodium hydroxide) aqueous solution; wherein the pure water is boiled and disinfected, all utensils are sterilized at 121 ℃ and the prepared analogue liquid is stored in a sealed way for 1 week.
The inventor finds out according to experiments that: the crystallization amount is high, the speed of the used glass for generating the hydroxyapatite under the same condition can be reflected to a certain extent, the crystallization amount is high, the bioactivity of the glass is high, but the XRD can only semi-quantitatively calculate the crystallization amount precipitated by the glass instead of accurately calculating, so the calculated crystallization amount by XRD is not the only index of reactivity, and the bioactivity of the glass needs to be illustrated by mutually contrasting the test results of XRD and SEM. In order to preliminarily screen glass components with better bioactivity, on the basis of a basic formula 45S5, the inventor preliminarily judges important components and content ranges thereof by researching to change the components and/or the content of the components, then detecting the crystallization amount of the obtained glass and preliminarily judging the important components and the content ranges thereof through component change and high-low change of the crystallization amount, and concretely, the important components and the content ranges are shown in tables 1 to 4, wherein each component is calculated by the mass (wt.%) of an oxide.
Table 1: group A bioglass component and amount of hydroxyapatite produced
Table 2: group B bioglass component and amount of hydroxyapatite produced
Table 3: group C bioglass component and amount of hydroxyapatite produced
Table 4: group D bioglass component and amount of hydroxyapatite produced
As can be seen from the devitrification amounts in tables 1 to 4, different amounts of L i were introduced into the base glass 45S5, respectively2O and/or CaF2It was found that the amount of crystallization after hydration could be increased within a certain range, but when the amount was increased after a certain range, the amount of crystallization was decreased. From tables 1 to 4, it can be seen that CaF is present in bioactive glass25.55 to 7.66 percent of L i20.84 to 1.25 percent of O, L i2O and CaF2When the mass ratio is 0.11 to 0.16, the amount of crystallization is high, which is more advantageous for improving the activity of the bioactive glass.
Example 2
According to the mass of the compound, the chemically pure raw material 28.4% SiO2，7.6％P2O5，26.2％Na2CO3，27.6％CaCO3，5.6％CaF2，1.5％Li2CO3，2.1％MgO，1.0％BaCO3Adding into a mortar, mixing uniformly, and placing into a corundum crucible. Placing the corundum crucible in a high-temperature electric furnace at room temperature, setting the heating speed of the electric furnace to 1h, heating to 400 ℃, then setting the heating speed to 1h, heating to 900 ℃, slowly heating to 1350 ℃ in 2h to fully decompose and melt each batch, and finally, keeping the temperature at 1350 ℃ for 2h to fully melt and clarify glass liquid; directly water-quenching the molten glassAnd obtaining the granular bioactive glass granules. And drying the obtained bioactive glass particles in a 110 ℃ oven for 6h, ball-milling for 4h by using a planetary ball mill (the medium is absolute ethyl alcohol, the rotating speed is 300r/min), then sieving by using a 500-mesh standard sieve, and drying for 4h at 110 ℃ to obtain bioactive glass particles with certain particle size.
Example 3
According to the mass of the compound, 29.1% SiO of the chemically pure raw material2，8.0％P2O5，27.5％Na2CO3，28.9％CaCO3，2.5％CaF2，1.6％Li2CO3，1.3％MgO，0.5％BaCO3Adding into a mortar, mixing uniformly, and placing into a corundum crucible. Placing the corundum crucible in a high-temperature electric furnace at room temperature, setting the heating speed of the electric furnace to 1h, heating to 400 ℃, then setting the heating speed to 1h, heating to 900 ℃, slowly heating to 1350 ℃ in 2h to fully decompose and melt each batch, and finally, keeping the temperature at 1350 ℃ for 2h to fully melt and clarify glass liquid; and directly water-quenching the molten glass liquid to obtain granular bioactive glass granules. And drying the obtained bioactive glass particles in a 110 ℃ oven for 6h, ball-milling for 4h by using a ball mill (the medium is absolute ethyl alcohol, the rotating speed is 300r/min), sieving by using a 500-mesh standard sieve, and drying for 4h at 110 ℃ to obtain bioactive glass particles with certain particle size.
Comparative example 1 (i.e. 45S5 formulation):
according to the mass of the compound, 33.01% SiO of the chemically pure raw material2，4.44％P2O5，30.48％Na2CO3，32.07％CaCO3Adding into a mortar, mixing uniformly, and placing into a corundum crucible. Placing the corundum crucible in a high-temperature electric furnace at room temperature, setting the heating speed of the electric furnace to 1h, heating to 400 ℃, then setting the heating speed to 1h, heating to 900 ℃, slowly heating to 1350 ℃ in 2h to fully decompose and melt each batch, and finally, keeping the temperature at 1350 ℃ for 2h to fully melt and clarify glass liquid; and directly water-quenching the molten glass liquid to obtain granular bioactive glass granules. Baking the obtained bioactive glass particles in an oven at 110 ℃ for 6h, and ball-milling for 4h by using a ball mill (the medium is absolute ethyl alcohol and the rotating speed is high)300r/min), then sieving by a 500-mesh standard sieve, and baking for 4 hours to obtain bioactive glass particles with certain particle sizes.
Example 4: activity assay
1. XRD test
Ball-milling, sieving and drying the obtained bioactive glass particles, and respectively measuring samples after being sieved by a 500-mesh sieve by using a Malvern 2000 laser particle sizer to ensure that the particle sizes are in the same range, wherein the particle size distribution of each sample is shown in a table 5; then weighing the same amount of 0.2g, placing in 100ml of SBF (simulated body fluid), and culturing at 37 ℃ for 24h in a constant-temperature oscillation water bath box; then the sample is transferred to a filter paper for filtration, the sample left on the filter paper is repeatedly washed by absolute ethyl alcohol, and after the filtration is finished, the sample is placed in an oven at 110 ℃, is dried for 4 hours and is placed in a dryer for cooling. And (3) stripping the cooled sample from the filter paper, grinding the sample in an agate mortar for 5min, fully and uniformly mixing the sample, and characterizing by XRD (X-ray diffraction), so as to determine whether the generated product is hydroxyapatite and the peak intensity of a characteristic peak.
Table 5: particle size distribution of each sample
| Sample (I) | D10(μm) | D50(μm) | D90(μm) |
| Example 2 | 3.452 | 7.137 | 14.419 |
| Example 3 | 2.987 | 6.662 | 14.870 |
| Comparative example 1 | 2.942 | 6.539 | 13.957 |
The XRD detection result is shown in figure 1. The spectra show that the substances produced in example 2, example 3 and comparative example 1 are all hydroxyapatite crystal phases. And under the same conditions, the crystallization amount of the hydroxyapatite contained in the example 2 and the example 3 is obviously higher than that of the 45S5 of the comparative example 1.
2. SEM test
Transversely cutting human teeth into sheet samples with the thickness of 2.5mm, separately placing the samples cut from each tooth to avoid the difference between different teeth, grinding and polishing by using a precision grinding and polishing machine, and corroding by using 6% citric acid aqueous solution (mass concentration) to expose dentin tubules to obtain human tooth samples.
A human tooth sample was simulated by brushing teeth with 1% (mass concentration) water (pure water) solution of bioactive glass of examples and comparative examples, respectively, for 30 seconds each side, and after brushing teeth, the tooth was placed in a beaker and rinsed 3 times with pure water, and then soaked with 100ml of SBF (simulated body fluid); repeating the above steps 1 time every 12 hours and replacing the simulated body fluid at the same time every day (e.g. 8:00 morning and 20:00 evening, each 1 time, 8:00 morning replacing the simulated body fluid); samples were taken at the same time after 3 days, 7 days, and 14 days (e.g., 8:00 am after 3 days, 8:00 am after 7 days, and 8:00 am after 14 days), and SEM test was performed after the samples were sonicated with absolute ethanol for 15min and dried in the shade.
The SEM test results are shown in fig. 2-5. From the SEM image, in the experimental example 2, hydroxyapatite tends to be generated around the dentinal micropores at 3d, most of the dentinal micropores were closed at 7d, and the sample of example 3 was slightly slower in the speed of repairing the dentinal micropores than the sample of example 2, but many of the dentinal micropores were closed at 7d under the same culture conditions. Whereas in comparative example 1, 14d was used to close a portion of the dentinal ostia.
The bioactive glasses of comparative example 1, example 2 and example 3 are larger in devitrification amount, i.e. more hydroxyapatite crystals are generated, than those of comparative example 1 in example 2 and example 3 under the same conditions through XRD test. Under the same conditions, the bioactive glass of example 2 and example 3 sealed more dentinal tubules at 14d, i.e. repaired the dentinal tubules faster, as measured by SEM, than the bioactive glass of comparative example 1. By combining the XRD and SEM test results of the comparative example 1, the example 2 and the example 3, under the same condition, more hydroxyapatite crystals are generated, more dentinal tubules are sealed, namely the bioactive glass of the example 2 and the example 3 has better activity than the bioactive glass of the comparative example 1, can quickly relieve and radically cure the tooth hypersensitivity, and has lasting effect.
While the methods of the present invention have been described in terms of preferred embodiments, it will be apparent to those of ordinary skill in the art that variations and modifications of the methods and applications described herein, as well as other suitable variations and combinations, may be made to implement and use the techniques of the present invention within the context, spirit and scope of the invention. Those skilled in the art can modify the process parameters appropriately to achieve the desired results with reference to the disclosure herein. It is expressly intended that all such similar substitutes and modifications which would be obvious to those skilled in the art are deemed to be included within the invention.
Claims (10)
1. A bioactive glass having a composition comprising, by mass of oxides:
2. the bioactive glass of claim 1 wherein CaF25.55 to 7.66 percent of L i20.84 to 1.25 percent of O, L i2O and CaF2The mass ratio is 0.11-0.16.
3. The bioactive glass of claim 1 for use in the preparation of a toothpaste, mouthwash, dentifrice, chewing gum, gel, or pharmaceutical carrier.
4. Use of the bioactive glass of claim 1 for the preparation of a composition for use in a method for the prevention or treatment of hypersensitivity of teeth, for a method for partial or total occlusion of dentinal tubules, for the prevention of incipient caries, for the prevention or treatment of tooth decay, for the remineralization of incipient caries, for the remineralization of enamel, for the occlusion of fissures in tooth structures, for the occlusion of point spaces in tooth structures, for a method for backing tooth structures, for a method for covering dental pulp, or/and in a method for the treatment of tooth structures after periodontal surgery, or for bone repair, or for skin repair.
5. A composition comprising the bioactive glass of claim 1 and an adjuvant.
6. The composition of claim 5, which is a cream, lotion, ointment, powder, gel or paste.
7. The composition of claim 5, wherein the bioactive glass is present in an amount of 0.1% to 50.0% based on the total mass of the composition.
8. The composition of claim 5, further comprising an antibacterial agent, a tartar control agent, a structure building agent, or a combination thereof.
9. A method of making the bioactive glass of claim 1 comprising the steps of:
1) weighing the raw materials of each component according to the formula proportion, uniformly mixing, and filling into a crucible;
2) placing the crucible in an electric furnace, setting the temperature rise speed of the electric furnace to be within 0.5-1.5 h, raising the temperature to 400-450 ℃, then setting the temperature to be within 0.5-1.5 h, raising the temperature to 900-950 ℃, then raising the temperature to 1300-1400 ℃ within 1.5-2.5 h, and finally preserving the temperature at 1300-1400 ℃ for 1-4 h to melt and clarify the molten glass to obtain molten glass;
3) and (3) quenching the molten glass liquid with water to obtain the bioactive glass.
10. The method of claim 9, further comprising:
4) baking the obtained bioactive glass particles in an oven at 100-120 ℃ for 4-8 h, and then ball-milling for 2-8 h by using a planetary ball mill, wherein the medium is absolute ethyl alcohol and the rotating speed is 150-500 r/min; sieving the mixture by a standard sieve of 400 to 600 meshes, and drying the mixture for 2 to 6 hours at the temperature of between 100 and 120 ℃ to obtain the bioactive glass.
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| CN116218071A (en) * | 2023-03-15 | 2023-06-06 | 佛山市瑞志医疗科技有限公司 | EVA antibacterial insole and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN113908067A (en) * | 2021-10-19 | 2022-01-11 | 四川涑爽医疗用品有限公司 | Composition for resisting tooth sensitivity, preparation method and application thereof, and oral care product containing composition |
| CN113908067B (en) * | 2021-10-19 | 2024-03-19 | 四川涑爽医疗用品有限公司 | Composition for resisting tooth sensitivity, preparation method and application thereof and oral care product containing composition |
| CN116218071A (en) * | 2023-03-15 | 2023-06-06 | 佛山市瑞志医疗科技有限公司 | EVA antibacterial insole and preparation method thereof |
| CN116218071B (en) * | 2023-03-15 | 2023-11-21 | 佛山市瑞志医疗科技有限公司 | EVA antibacterial insole and preparation method thereof |
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