CN111474694A - Large-view-field miniature endoscope - Google Patents
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Abstract
Description
技术领域technical field
本发明涉及医疗诊断成像设备技术领域,具体涉及一种大视场微型内窥镜。The invention relates to the technical field of medical diagnostic imaging equipment, in particular to a large field of view miniature endoscope.
背景技术Background technique
随着科学技术的发展,医用内窥镜已经被广泛应用与医疗领域,它是人类窥视、治疗人 体内器官的重要工具之一。内窥镜在200多年的发展过程中结构发生了四次大的改进,从最 初的硬管式内窥镜、半曲式内窥镜到纤维内窥镜,又到如今的电子内窥镜,影像质量也发生 了一次次质的飞跃。当今使用LED照明,内窥镜可以获得彩色相片或彩色电视图像,同时, 其图像不再是组织器官的普通图像,而是如同在显微镜下观察到的微观图像,微小病变清晰 可辨。根据现有的临床经验,内窥镜的微型探头体积越小,硬性段越短,能够最大程度减小 病人的痛楚,所以内窥镜一直朝着小型化发展。目前的内窥镜具有较大的放大率,造成视场 很小。With the development of science and technology, medical endoscope has been widely used in the medical field. It is one of the important tools for humans to peep and treat the internal organs of the human body. In the course of more than 200 years of development, the structure of endoscope has undergone four major improvements, from the initial rigid endoscope, semi-curved endoscope to fiber endoscope, to today's electronic endoscope, Image quality has also undergone a sub-quality leap. Using LED lighting today, endoscopes can obtain color photos or color TV images. At the same time, the images are no longer ordinary images of tissues and organs, but microscopic images like those observed under a microscope, and tiny lesions can be clearly identified. According to the existing clinical experience, the smaller the volume of the micro-probe of the endoscope, the shorter the rigid segment, which can minimize the pain of the patient, so the endoscope has been developing towards miniaturization. Current endoscopes have large magnifications, resulting in a small field of view.
随着近年来医疗诊断的发展,传统的内窥镜狭小视场无法满足目前医疗诊断的需要。目 前英国和美国各有一种设计实现了超大视场,并且两种设计均已商业化,这两种设计均是依 靠大大提高入射光束直径从而带来大视场、大通光量的效果,但是这两种设计会造成内窥镜 微型探头的物镜非常昂贵而且体积较大,不符合内窥镜的发展趋势。With the development of medical diagnosis in recent years, the narrow field of view of traditional endoscope cannot meet the needs of current medical diagnosis. At present, there is a design in the United Kingdom and the United States that achieves a large field of view, and both designs have been commercialized. Both designs rely on greatly increasing the diameter of the incident beam to bring about a large field of view and a large amount of light. However, these two designs Such a design will cause the objective lens of the endoscope micro-probe to be very expensive and bulky, which does not conform to the development trend of endoscopes.
发明内容SUMMARY OF THE INVENTION
本发明意在提供一种大视场微型内窥镜,在保持入射光束直径不变的前提下,增大视场 角,减小内窥镜微型探头的体积,解决现有技术中为实现大视场造成物镜及微型探头体积增 大的问题。The present invention aims to provide a large field of view miniature endoscope. On the premise of keeping the diameter of the incident beam unchanged, the field of view angle is increased, and the volume of the endoscope microprobe is reduced. The field of view causes the problem of increasing the volume of the objective lens and the micro-probe.
方案基本如下:一种大视场微型内窥镜,包括微型探头,微型探头包括外壳、与外壳固 定的物镜和设于外壳内的扫描器,所述物镜根据激发光波长计算的后焦平面位于物镜镜体之 外,扫描器位于物镜的后焦平面位置处。The scheme is basically as follows: a large field of view miniature endoscope, including a miniature probe, the miniature probe includes a casing, an objective lens fixed with the casing, and a scanner arranged in the casing, the back focal plane of the objective lens calculated according to the wavelength of the excitation light is located at Outside of the objective body, the scanner is located at the back focal plane of the objective.
有益效果:本方案与物镜(scan lens)相比,本发明具有超短焦距,高数值孔径,较小视场角。本方案具有较大视场角和外置的后焦平面,因为本方案与普通扫描透镜和普通显 微镜物镜都有很大区别,是独一无二的。在使用时,使用单一的单轴扫描器或单一的双轴扫 描器时,单一的单轴扫描器或单一的双轴扫描器位于物镜的后焦平面;使用一组两个的单轴 扫描器时,物镜的后焦平面位于一组两个的单轴扫描器的中间位置。由于本发明的后焦平面 远离镜体(通常为数毫米远),因此有足够的空间安装扫描器,而无需如同传统激光扫描内 窥镜中扫描器和物镜之间设置扫描透镜和套筒透镜(tube lens),显微镜扫描和成像光路的 长度被大大缩短,本发明用于将由扫描器反射的激发光束聚焦在样品中,并收集样品中激发 出的发射光信号,经聚焦透镜耦合进用于传输光信号的光纤或用于检测光信号的光电检测 器。Beneficial effects: Compared with the objective lens (scan lens), the present invention has ultra-short focal length, high numerical aperture and smaller field of view. This solution has a large field of view and an external rear focal plane, because this solution is very different from ordinary scanning lenses and ordinary microscope objective lenses, and is unique. In use, when using a single uniaxial scanner or a single biaxial scanner, the single uniaxial scanner or a single biaxial scanner is located in the back focal plane of the objective; use a set of two uniaxial scanners , the back focal plane of the objective is in the middle of a set of two uniaxial scanners. Since the back focal plane of the present invention is far away from the mirror body (usually a few millimeters away), there is enough space to install the scanner without the need for a scanning lens and a tube lens (as in conventional laser scanning endoscopes) between the scanner and the objective lens ( tube lens), the length of the scanning and imaging optical path of the microscope is greatly shortened, the present invention is used to focus the excitation beam reflected by the scanner in the sample, and collect the emitted light signal excited in the sample, which is coupled into the sample for transmission through the focusing lens Optical fibers for optical signals or photodetectors for detecting optical signals.
进一步,所述扫描器采用二向色镜扫描器,二向色镜扫描器包括驱动器和若干二向色镜, 所述二向色镜用于反射激光并可供非线性光学信号穿过;驱动器用于根据指令改变二向射镜 的角度,驱动器包括若干可供非线性光学信号透射过的镜体,二向色镜固定在镜体的表面。Further, the scanner adopts a dichroic mirror scanner, and the dichroic mirror scanner includes a driver and several dichroic mirrors, and the dichroic mirrors are used to reflect laser light and allow nonlinear optical signals to pass through; the driver For changing the angle of the dichroic mirror according to the instruction, the driver includes several mirror bodies through which the nonlinear optical signal can transmit, and the dichroic mirror is fixed on the surface of the mirror body.
相对现有技术中传统的如MEMS扫描器,该二向扫描器可以在没有扫描透镜和套筒透镜 的前提下满足成像质量,减少了外壳内的镜片数量,减小微型探头的体积,同时大大提高了 成像速度。Compared with traditional scanners such as MEMS in the prior art, the two-way scanner can meet the imaging quality without scanning lens and tube lens, reduce the number of lenses in the housing, reduce the volume of the micro probe, and greatly reduce the size of the micro-probe. Improved imaging speed.
进一步,所述二向色镜包括超薄片,超薄片上镀有二向色薄膜。Further, the dichroic mirror includes an ultra-thin sheet, and the ultra-thin sheet is coated with a dichroic film.
这样获得的二向色镜可以更薄更轻,有利于让微型探头能够进一步减小体积和重量。The dichroic mirror obtained in this way can be thinner and lighter, which is beneficial to further reduce the size and weight of the micro-probe.
进一步,所述物镜包括出射光线依次通过的透镜一、透镜二、透镜三、透镜四和透镜五, 所述透镜一为凹凸透镜,透镜二为双凸透镜,透镜三为凸凹透镜,透镜四为凸凹透镜,透镜 五为双凸透镜。物镜以这种组合可以满足焦平面位于镜体之外。Further, the objective lens comprises a
进一步,所述透镜一相对像侧表面S11和相对物侧表面S12的曲率半径分别为-5.422mm 和-15.096mm;所述透镜二相对像侧表面S21和相对物侧表面S22的曲率半径分别为40.057mm 和-119.509mm;所述透镜三相对像侧表面S31和相对物侧表面S32的曲率半径分别为 18.574mm和39.689mm;所述透镜四相对像侧表面S41和相对物侧表面S42的曲率半径分别 为6.873mm和8.074mm;所述透镜四相对像侧表面S51和相对物侧表面S52的曲率半径分别 为103.816mm和-26.042mm。Further, the curvature radii of the first lens relative to the image side surface S11 and the relative object side surface S12 are -5.422mm and -15.096mm respectively; the curvature radii of the second lens relative to the image side surface S21 and the relative object side surface S22 are respectively 40.057mm and -119.509mm; the curvature radii of the lens three relative to the image side surface S31 and the relative object side surface S32 are 18.574mm and 39.689mm respectively; the curvature of the lens four relative to the image side surface S41 and the opposite object side surface S42 The radii are 6.873mm and 8.074mm respectively; the radii of curvature of the four lens surfaces opposite the image side surface S51 and the opposite object side surface S52 are 103.816mm and -26.042mm respectively.
相对像侧表面即透镜距离扫描对象较远的表面,相对物侧表面即透镜距离扫描对象较近 的表面。各透镜的表面曲率按照上述参数设置,在保证大视场的前提下,物镜体积相对较小。The opposite image side surface is the surface where the lens is farther from the scanning object, and the opposite object side surface is the surface where the lens is closer to the scanning object. The surface curvature of each lens is set according to the above parameters. Under the premise of ensuring a large field of view, the volume of the objective lens is relatively small.
进一步,所述S11的厚度为14.307mm,S12的厚度为0.2mm,S21的厚度为1.5mm, S22的厚度为0.2mm,S31的厚度为1.674mm,S32的厚度为0.2mm,S41的厚度为6.083mm, S42的厚度为0.75mm,S51的厚度为6.083mm,S52的厚度为0.75mm。Further, the thickness of the S11 is 14.307mm, the thickness of the S12 is 0.2mm, the thickness of the S21 is 1.5mm, the thickness of the S22 is 0.2mm, the thickness of the S31 is 1.674mm, the thickness of the S32 is 0.2mm, and the thickness of the S41 is 6.083mm, the thickness of the S42 is 0.75mm, the thickness of the S51 is 6.083mm, and the thickness of the S52 is 0.75mm.
个透镜以上述参数设置,在保证大视场的前提下,物镜的轴向长度较短。Each lens is set with the above parameters, and under the premise of ensuring a large field of view, the axial length of the objective lens is short.
进一步,所述S11的半径为6mm,S12的半径为14mm,S21的半径为14mm,S22的半 径为14mm,S31的半径为14mm,S32的半径为14mm,S41的半径为12mm,S42的半径为 6.6mm,S51的半径为7.2mm,S52的半径为7.2mm。Further, the radius of S11 is 6mm, the radius of S12 is 14mm, the radius of S21 is 14mm, the radius of S22 is 14mm, the radius of S31 is 14mm, the radius of S32 is 14mm, the radius of S41 is 12mm, and the radius of S42 is 6.6mm, the S51 has a 7.2mm radius, and the S52 has a 7.2mm radius.
这样在物镜满足大视场情况下,上述各面的半径组成的物镜截面积较小。In this way, when the objective lens satisfies a large field of view, the cross-sectional area of the objective lens composed of the radii of the above-mentioned surfaces is small.
进一步,所述透镜一、透镜二、透镜三、透镜四、透镜五的材质均为光学玻璃或高分子 聚合物或红外成像材料。光学玻璃或高分子聚合物或红外成像材料为本领域中透镜的常用材 料。Further, the materials of the first lens, the second lens, the third lens, the fourth lens and the fifth lens are all optical glass or high molecular polymer or infrared imaging material. Optical glass or high molecular polymer or infrared imaging material are commonly used materials for lenses in the field.
进一步,所述物镜的数值孔径大于等于0.7。Further, the numerical aperture of the objective lens is greater than or equal to 0.7.
进一步,所述物镜的视场角大于等于15度。Further, the field angle of the objective lens is greater than or equal to 15 degrees.
附图说明Description of drawings
图1为本发明微型探头的的结构示意图。FIG. 1 is a schematic structural diagram of a micro-probe of the present invention.
图2为本发明实施例物镜的光学结构示意图。FIG. 2 is a schematic diagram of an optical structure of an objective lens according to an embodiment of the present invention.
图3为本发明实施例的激发光波长的场曲和畸变图。FIG. 3 is a field curvature and distortion diagram of excitation light wavelengths according to an embodiment of the present invention.
图4为本发明实施例的激发光波长的焦平面渐晕图。FIG. 4 is a vignetting diagram of a focal plane of excitation light wavelengths according to an embodiment of the present invention.
图5为本发明实施例扫描器的示意图。FIG. 5 is a schematic diagram of a scanner according to an embodiment of the present invention.
具体实施方式Detailed ways
下面通过具体实施方式进一步详细说明:The following is further described in detail by specific embodiments:
说明书附图中的附图标记包括:透镜一1、透镜二2、透镜三3、透镜四4、透镜五5,扫描器6、激光输入光纤90、激光输出光纤91、驱动器22、二向色镜33、微型探头50。The reference signs in the drawings include: lens one 1, lens two 2, lens three 3, lens four 4, lens five 5,
实施例基本如下:The embodiment is basically as follows:
一种大视场微型内窥镜,如图1所示,包括微型探头50,微型探头50包括外壳和物镜, 外壳为高分子聚合物的材料的密封结构,外壳内部设有扫描器6和多个镜片,外壳的上端连 接有激光输入光纤90和激光输出光纤91,物镜固定在外壳的下端即前孔径,扫描器6位于 物镜的上方。扫描器6与外壳之间转动连接,从而扫描器6可改变角度进行扫描。输出光纤 发射的激光经二向射镜反射后从物镜出射照射到人体组织上。A large field of view miniature endoscope, as shown in Figure 1, includes a
如图2所示,物镜包括透镜一1、透镜二2、透镜三3、透镜四4和透镜五5,扫描器6 位于物镜根据激发光波长计算的后焦平面上。其中透镜一1为凹凸透镜,透镜二2为双凸透镜,透镜三3为凸凹透镜,透镜四4为凸凹透镜,透镜五5为双凸透镜。As shown in FIG. 2 , the objective lens includes lens one 1, lens two 2, lens three 3, lens four 4 and lens five 5, and the
透镜一1具有相对像侧的表面S11和相对物侧的表面S12,透镜二2具有相对像侧的表 面S21和相对物侧的表面S22,透镜三3具有相对像侧的表面S31和相对物侧的表面S32,透镜四4具有相对像侧的表面S41和相对物侧的表面S42,透镜五5具有相对像侧的表面S51和相对物侧的表面S52。Lens one 1 has a surface S11 opposite to the image side and a surface S12 opposite to the object side, lens two 2 has a surface S21 opposite the image side and a surface S22 opposite the object side, and lens three 3 has a surface S31 opposite the image side and the opposite object side The lens four 4 has a surface S41 opposite the image side and a surface S42 opposite the object side, and the lens five 5 has a surface S51 opposite the image side and a surface S52 opposite the object side.
透镜一1、透镜二2、透镜三3、透镜四4、透镜五5的材料为光学玻璃或高分子聚合物或红外成像材料。The material of lens one 1, lens two 2, lens three 3, lens four 4 and lens five 5 is optical glass or high molecular polymer or infrared imaging material.
各透镜表面的数据满足下表:The data of each lens surface satisfies the following table:
其中激发光波长为920纳米,发射光波长为520纳米。The excitation light wavelength is 920 nanometers, and the emission light wavelength is 520 nanometers.
其中物镜的数值孔径为0.7,工作距离为1毫米,视场直径1.65毫米。The numerical aperture of the objective lens is 0.7, the working distance is 1 mm, and the diameter of the field of view is 1.65 mm.
本实施例用于非线性光学成像,因此对消色差要求不高。This embodiment is used for nonlinear optical imaging, so the requirement for achromatic aberration is not high.
图2所示为本实施例激发光波长的场曲和畸变图,由于本实施例用于活体生物组织成像, 对于场曲的畸变的要求不高。FIG. 2 shows the field curvature and distortion diagram of the excitation light wavelength of this embodiment. Since this embodiment is used for imaging of living biological tissue, the requirements for the distortion of the field curvature are not high.
图3所示本实施例的激发光焦平面渐晕图,激发光波长在最大视角下达到大于0.5的透 射效率。Fig. 3 shows the vignetting diagram of the excitation light focal plane of this embodiment, and the excitation light wavelength reaches a transmission efficiency greater than 0.5 at the maximum viewing angle.
如图5所示,扫描器6采用二向色镜扫描器,二向色镜扫描器包括驱动器22和若干二 向色镜33,所述二向色镜33用于反射激光并可供非线性光学信号穿过;驱动器22用于根据 指令改变二向色镜33的角度,驱动器22包括若干可供非线性光学信号透射过的镜体,二向 色镜33固定在镜体的表面。As shown in FIG. 5 , the
二向色镜33包括超薄片,超薄片上镀有二向色薄膜,二向色镜33可反射激光入射光纤 90入射的激光,可透射人体组织被激发的发射光(比如荧光光子)。相对现有技术中传统的 如MEMS扫描器6,该二向扫描器6可以在没有扫描透镜和套筒透镜的前提下满足成像质量, 减少了外壳内的镜片数量,减小微型探头50的体积,同时大大提高了成像速度。The
以上的仅是本发明的实施例,方案中公知的具体结构及特性等常识在此未作过多描述。 应当指出,对于本领域的技术人员来说,在不脱离本发明结构的前提下,还可以作出若干变 形和改进,这些也应该视为本发明的保护范围,这些都不会影响本发明实施的效果和专利的 实用性。本申请要求的保护范围应当以其权利要求的内容为准,说明书中的具体实施方式等 记载可以用于解释权利要求的内容。The above are only the embodiments of the present invention, and common knowledge such as well-known specific structures and characteristics in the solution are not described too much here. It should be pointed out that for those skilled in the art, some modifications and improvements can be made without departing from the structure of the present invention. These should also be regarded as the protection scope of the present invention, and these will not affect the implementation of the present invention. Effectiveness and utility of patents. The scope of protection claimed in this application should be based on the content of the claims, and the descriptions of the specific implementation manners in the description can be used to interpret the content of the claims.
Claims (10)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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CN2019100633327 | 2019-01-23 | ||
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CN201921248597.6U Expired - Fee Related CN210155404U (en) | 2019-01-23 | 2019-08-02 | Large-view-field scanning imaging structure, microscope and microprobe |
CN201910713367.0A Pending CN111474694A (en) | 2019-01-23 | 2019-08-02 | Large-view-field miniature endoscope |
CN201910713390.XA Pending CN111474695A (en) | 2019-01-23 | 2019-08-02 | Large-field microscope objective lens |
CN201921247899.1U Expired - Fee Related CN210155401U (en) | 2019-01-23 | 2019-08-02 | Large-field microscope objective lens |
CN201921247897.2U Expired - Fee Related CN210572987U (en) | 2019-01-23 | 2019-08-02 | Large-view-field miniature endoscope |
CN201910717807.XA Pending CN111474696A (en) | 2019-01-23 | 2019-08-05 | Large-view-field head-mounted microscope |
CN201921256740.6U Expired - Fee Related CN210155407U (en) | 2019-01-23 | 2019-08-05 | Large-view-field head-mounted microscope |
CN201922220396.1U Active CN211086790U (en) | 2019-01-23 | 2019-12-11 | Large-view-field handheld microscope |
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CN201921248382.4U Expired - Fee Related CN210166557U (en) | 2019-01-23 | 2019-08-02 | Large-view-field imaging lens |
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CN201921247897.2U Expired - Fee Related CN210572987U (en) | 2019-01-23 | 2019-08-02 | Large-view-field miniature endoscope |
CN201910717807.XA Pending CN111474696A (en) | 2019-01-23 | 2019-08-05 | Large-view-field head-mounted microscope |
CN201921256740.6U Expired - Fee Related CN210155407U (en) | 2019-01-23 | 2019-08-05 | Large-view-field head-mounted microscope |
CN201922220396.1U Active CN211086790U (en) | 2019-01-23 | 2019-12-11 | Large-view-field handheld microscope |
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CN210166557U (en) * | 2019-01-23 | 2020-03-20 | 苏州溢博伦光电仪器有限公司 | Large-view-field imaging lens |
CN210166558U (en) * | 2019-03-18 | 2020-03-20 | 苏州溢博伦光电仪器有限公司 | Microscope with high fluorescence collection rate |
CN210155422U (en) * | 2019-03-19 | 2020-03-17 | 苏州溢博伦光电仪器有限公司 | Multi-facet scanner comprising photodetector |
CN113189741A (en) * | 2021-03-31 | 2021-07-30 | 苏州溢博伦光电仪器有限公司 | High numerical aperture scanning lens |
CN113189758A (en) * | 2021-03-31 | 2021-07-30 | 苏州溢博伦光电仪器有限公司 | Microscope objective |
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CN210572987U (en) | 2020-05-19 |
CN210155404U (en) | 2020-03-17 |
CN111474696A (en) | 2020-07-31 |
CN111474695A (en) | 2020-07-31 |
CN110794565A (en) | 2020-02-14 |
CN211086790U (en) | 2020-07-24 |
CN210155407U (en) | 2020-03-17 |
CN210155401U (en) | 2020-03-17 |
CN210166557U (en) | 2020-03-20 |
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