CN111413338B - Sample detection system - Google Patents
Sample detection system Download PDFInfo
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- CN111413338B CN111413338B CN202010268674.5A CN202010268674A CN111413338B CN 111413338 B CN111413338 B CN 111413338B CN 202010268674 A CN202010268674 A CN 202010268674A CN 111413338 B CN111413338 B CN 111413338B
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- 238000001514 detection method Methods 0.000 title claims abstract description 48
- 239000000758 substrate Substances 0.000 claims abstract description 19
- 238000000386 microscopy Methods 0.000 claims description 46
- 230000005540 biological transmission Effects 0.000 claims description 7
- 239000002699 waste material Substances 0.000 claims description 7
- 239000004576 sand Substances 0.000 claims 1
- 230000007246 mechanism Effects 0.000 description 11
- 230000033001 locomotion Effects 0.000 description 7
- 239000000969 carrier Substances 0.000 description 6
- 238000010586 diagram Methods 0.000 description 6
- 238000000034 method Methods 0.000 description 6
- 230000008569 process Effects 0.000 description 6
- 230000032258 transport Effects 0.000 description 6
- 239000000428 dust Substances 0.000 description 3
- 238000009825 accumulation Methods 0.000 description 2
- 238000005070 sampling Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 210000000582 semen Anatomy 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/84—Systems specially adapted for particular applications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
- G01N21/13—Moving of cuvettes or solid samples to or from the investigating station
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
- G01N2021/0106—General arrangement of respective parts
- G01N2021/0112—Apparatus in one mechanical, optical or electronic block
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- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Sampling And Sample Adjustment (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
- Microscoopes, Condenser (AREA)
Abstract
The invention discloses a sample detection system, which comprises a substrate, a microscopic examination device and a third conveying device, wherein an output position is arranged on the substrate; the microscopic examination device comprises a microscopic examination platform and a lens, wherein the microscopic examination platform is provided with a guide chute, and a microscopic examination position is also arranged on the microscopic examination platform; the third conveying device is used for conveying the carrier to the microscopic examination position of the microscopic examination platform through the output position and the guide chute, and the lens is used for picking up the image of the carrier on the microscopic examination position; the guide chute is provided with a guide inlet at one end close to the output position, and the guide inlet is in a horn shape. Above-mentioned sample detecting system, the one end that leads the spout and export the position and be close to is equipped with the leading-in mouth, and the leading-in mouth is loudspeaker form, like this, is convenient for export the position and lead the entry counterpoint of spout to can be convenient for the carrier get into and lead the spout, and then improved sample detecting system's detection efficiency.
Description
The application relates to a sample detection system and a sample detection method which are applied by the applicant in 2016 and 08/29, and are divided application of China patent application with the application number 201610750374.4.
Technical Field
The invention relates to the technical field of medical instruments, in particular to a sample detection system.
Background
When a patient is detected, sometimes the sample to be detected (such as stool, urine, semen, leucorrhea and the like) of the patient is detected, the sample is conveyed to a microscopic examination platform during detection, and then a microscope is used for aiming at the sample to collect images, so that the sample is detected. In the sample detection system, a carrier carrying a sample is conveyed to a microscopic examination platform through a conveying device, so that the sample is detected by a microscope. However, when the carrier is conveyed onto the microscopic examination platform by the conveying device, an error exists in alignment between the conveying device and the entrance of the microscopic examination platform, so that the carrier is not easy to convey onto the microscopic examination platform, and the detection efficiency is affected.
Disclosure of Invention
Based on this, it is necessary to provide a sample detection system capable of improving the detection efficiency, aiming at the problem that the carrier of the conventional sample detection system is not easy to be conveyed to the microscopic detection platform, resulting in low detection efficiency.
The sample detection system comprises a substrate, a microscopic examination device and a third conveying device, wherein an output position is arranged on the substrate; the microscopic examination device comprises a microscopic examination platform and a lens, wherein the microscopic examination platform is provided with a guide chute, and a microscopic examination position is also arranged on the microscopic examination platform; the third conveying device is used for conveying the carrier to the microscopic examination position of the microscopic examination platform through the output position and the guide chute, and the lens is used for picking up the image of the carrier on the microscopic examination position;
The guide chute is provided with a guide inlet at one end close to the output position, and the guide inlet is in a horn shape.
Above-mentioned sample detecting system, the one end that leads the spout and export the position and be close to is equipped with the leading-in mouth, and the leading-in mouth is loudspeaker form, like this, is convenient for export the position and lead the entry counterpoint of spout to can be convenient for the carrier get into and lead the spout, and then improved sample detecting system's detection efficiency.
In one embodiment, the guide chute is movable relative to the output position in a conveying direction perpendicular to the third conveying device.
In one embodiment, the microscopy platform comprises an eighth driving piece and a first conveying plate, and the guide chute is arranged on the first conveying plate;
Wherein the eighth driving member drives the first conveying plate to move in a conveying direction perpendicular to the third conveying device.
In one embodiment, a pressing sheet for pressing the carrier located at the microscopic examination position is arranged at the position, corresponding to the microscopic examination position, of the microscopic examination platform.
In one embodiment, the microscopy platform comprises a first conveying plate, the guide chute is arranged on the first conveying plate, the pressing sheet is fixed outside the guide chute of the first conveying plate and partially stretches into the guide chute, and a gap is reserved between the part stretching into the guide chute and the bottom of the guide chute.
In one embodiment, a slide guiding protrusion is arranged at the bottom of the slide guiding groove;
when the carrier is positioned in the microscopic examination position, the carrier is pressed between the pressing sheet and the slide guiding protrusion.
In one embodiment, the guide chute is further provided with a light transmission area, and the microscopic examination position is arranged corresponding to the light transmission area;
The sliding guide protrusions are two convex strips which are parallel to each other, and the two convex strips are respectively positioned at two sides of the light transmission area.
In one embodiment, two sides of the guide chute are respectively provided with one pressing sheet.
In one embodiment, a pushing position is further provided on the substrate, and the third conveying device is configured to convey the carrier from the pushing position to the microscopy position of the microscopy platform of the microscopy device through the output position and the guide chute;
The sample detection system further comprises a first detector arranged corresponding to the pushing position, and when the first detector detects that the pushing position has a carrier, the third conveying device is started to push the carrier to the microscopic examination device.
In one embodiment, the third conveying device is disposed on the substrate;
the third conveying device comprises a fourth conveying belt, a sixth driving piece, a sliding block and a pushing rod, wherein the sixth driving piece, the sliding block and the pushing rod are connected to the fourth conveying belt and can be driven to move by the fourth conveying belt, and the sixth driving piece is used for pushing the sliding block and the pushing rod to move.
Drawings
FIG. 1 is a schematic diagram of the overall structure of a sample detection system according to a preferred embodiment of the present invention;
FIG. 2 is a schematic diagram of a sample application device of the sample detection system shown in FIG. 1;
FIG. 3 is a schematic diagram of a limiting mechanism of the sample detection system shown in FIG. 1;
FIG. 4 is a schematic diagram illustrating a limiting mechanism and a first conveying device of the sample detection system shown in FIG. 1;
FIG. 5 is a schematic view of the elastic member of the limiting mechanism shown in FIG. 3;
FIG. 6 is a schematic diagram of a second transport device of the sample detection system of FIG. 1;
FIG. 7 is a schematic diagram of a third conveying device of the sample detection system shown in FIG. 1;
FIG. 8 is a schematic view of an angle structure of a microscopy stage of the sample detection system of FIG. 1;
FIG. 9 is a schematic view of another angular configuration of the microscopy stage of FIG. 8;
FIG. 10 is a schematic view of a portion of the microscopy stage of FIG. 8.
Detailed Description
In order that the invention may be readily understood, a more complete description of the invention will be rendered by reference to the appended drawings. Preferred embodiments of the present invention are shown in the drawings. This invention may, however, be embodied in many different forms and should not be construed as limited to the embodiments set forth herein. Rather, these embodiments are provided so that this disclosure will be thorough and complete.
It will be understood that when an element is referred to as being "fixed to" another element, it can be directly on the other element or intervening elements may also be present. When an element is referred to as being "connected" to another element, it can be directly connected to the other element or be present therebetween.
Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. The terminology used herein in the description of the invention is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention. The term "and/or" as used herein includes any and all combinations of one or more of the associated listed items.
Referring to fig. 1, a sample detection system in a preferred embodiment of the present invention includes a substrate 10, a carrier storage device 20, a first conveying device 30, a second conveying device 40, a third conveying device 50, and a microscopic examination device 60, wherein a sample loading station 102, a transfer station 104, a pushing station 106, and an output station 108 are disposed on the substrate 10. The microscopic examination device 60 comprises a microscopic examination platform 62 and a lens 64, and a microscopic examination position is arranged on the microscopic examination platform 62. The first conveying device 30 is used for conveying the carrier 100 in the carrier storage device 20 to the loading position 102 and conveying the carrier to the transfer position 104 after loading. The second conveyor 40 is used to convey the carrier 100 from the transfer station 104 to the push station 106, and the third conveyor 50 is used to convey the carrier 100 from the push station 106 via the output station 108 to the microscopy station 62 of the microscopy apparatus 60 and to push the carrier away from the microscopy station. The mirror position of the mirror platform 62 is movable in a first direction and a second direction to adjust the position of the mirror position of the lens 64, so that the lens 64 is aligned with the mirror position carrier 100, and the lens 64 is used to map the mirror position carrier 100. It should be understood that the loading station 102, the transferring station 104, the pushing station 106, and the output station 108 may not be disposed on the substrate 10, as long as there is a position for accommodating the carrier 100.
According to the sample detection system, the carrier 100 is sequentially conveyed to the microscopic examination device 60 after being loaded from the carrier storage device 20 through the three conveying devices, the lens 64 and the carrier 100 are aligned through movement of the microscopic examination platform 62, an operator is not required to operate a sample to be detected in the whole detection process, and the risk of pollution to the operator can be effectively reduced.
In this embodiment, the carrier storage device 20 may be disposed on the substrate 10, and is used for storing clean carriers (such as a counting plate).
In this embodiment, the carrier storage device 20 includes a translation plate disposed therein, on which multiple groups of carriers 100 can be placed side by side, and the sample detection system further includes a carrier translation device 70, where the carrier translation device 70 is configured to drive the translation plate to translate relative to the substrate 10 so that different groups of carriers 100 can be aligned with the first conveying device 30 respectively. Each of the plurality of sets of carriers 100 may house one or more carriers 100.
Specifically, the carrier translating device 70 may include a first driving member and a first conveying belt, where the first conveying belt is connected to the translating plate, and the first driving member rotates to drive the first conveying belt to move, so as to drive the translating plate to move. It will be appreciated that the carrier translating device 70 may also be a telescopic mechanism, such as an oil cylinder, with a piston rod or a cylinder body connected to the translating plate, where the oil cylinder stretches to drive the translating plate to move.
Referring to fig. 2,3 and 4, in the present embodiment, the first conveying device 30 includes a second driving member, a moving block 302 driven to move by the second driving member, and a weight 304 rotatably connected to the moving block 302, wherein the weight 304 can be rotated to a first position and a second position, when the weight 304 is in the first position, the weight 304 is in a natural state, and the weight 304 is partially located on the moving path of the carrier 100, and when the weight 304 is in the second position, the weight 304 is separated from the moving path of the carrier 100. The weight of the weight 304 at one end of the shaft is greater than the weight at the other end, so that the resistance to rotation of the weight 304 in one direction is greater than the resistance to rotation in the opposite direction. In this embodiment, the second driving member is a motor. By arranging the weight 304, when the carrier 100 in the carrier storage device 20 needs to be transported to the sample loading position 102, the moving block 302 and the weight 304 are positioned at the leftmost end as shown in fig. 4, and the weight 304 contacts the carrier 100 as the second driving member drives the moving block 302 and the weight 304 to move rightwards, and at this time, the driving force required for the rotation of the weight 304 is larger, the weight 304 cannot rotate, so as to push the carrier 100 to move rightwards; when carrier 100 reaches the predetermined position, moving block 302 and weight 304 move to the left, and weight 304 is located at the right side of carrier storage device 20, and when weight 304 contacts the right end of carrier 100 in carrier storage device 20, the driving force required for rotation of weight 304 is smaller, and weight 304 is pushed by carrier 100 to rotate during the leftward movement to avoid being located on the moving path of carrier 100, so that weight 304 returns to the left side of carrier storage device 20 and is ready for pushing the next carrier 100 to the right.
Specifically, the first conveying device 30 further includes a second conveying belt 305 driven by the second driving member, and the moving block 302 is fixed to the second conveying belt 305.
Specifically, the first conveying device 30 may further include a guide rail 306, and the moving block 302 moves against the guide rail 306. In this embodiment, the guide rail 306 may be disposed on the substrate 10.
In this embodiment, the sample detection system further comprises a loading device 80, the loading device 80 comprising a loading needle 802 for loading the sample onto the carrier 100 at the loading station 102.
In this embodiment, the sample loading device 100 further includes a third driving member 804, a transmission mechanism connected to the third driving member 804, and a fixed block 810 connected to the transmission mechanism, where the sample loading needle 802 is fixedly connected to the fixed block 810, and the third driving member 804 rotates to drive the sample loading needle 802 to move up and down; the loading device 100 further includes a fourth driving member, and the fixing block 810 is driven by the fourth driving member to move in a direction perpendicular to the up-down direction. The loading needle 802 is thus movable in two directions to effect sampling and, after sampling, to a position aligned with the loading site for loading. Specifically, the third driving member and the fourth driving member may each be a motor.
Specifically, the carrier 100 is provided with a loading hole 1002, and the loading needle 802 is aligned with the loading hole 1002 for loading during loading.
In this embodiment, the sample loading device 80 further includes a limiting mechanism 812 disposed corresponding to the sample loading position 102, where the limiting mechanism 812 includes an elastic member 8122, and the elastic member 8122 is used to elastically support the carrier 100, so as to limit the movement of the carrier 100 in the up-down direction. When the carrier 100 is located at the sample loading position 102, the elastic piece 8122 of the limiting mechanism 812 elastically abuts against the carrier 100, and the carrier 100 is pressed by the elastic piece 8122 and cannot be carried up in the process of upward withdrawal after the sample loading of the sample loading needle 802 is completed, so that the carrier 100 can normally enter the subsequent process; meanwhile, in the process of moving the carrier 100 towards the loading position 102, the carrier 100 gradually receives the resistance of the elastic piece 8122 after contacting the elastic piece 8122 and gradually decelerates until stopping, thus, the carrier 100 is prevented from deviating from the loading position 102 due to the motion inertia, the accurate positioning of the carrier 100 is realized, and the loading needle 802 is ensured to be aligned with the loading hole 1002 of the carrier 100.
In this embodiment, referring to fig. 5, the elastic member 8122 includes a mounting portion 81222 fixedly connected to the substrate 10 and a contact portion 81224 elastically pressing against the carrier 100, the contact portion 81224 is connected to the mounting portion 81222, and the contact portion 81224 is an elastic sheet.
In this embodiment, the contact portion 81224 includes a first section connected to one side of the mounting portion 81222 and a second section connected to one end of the first section, and the second section is inclined at an angle with respect to the first section. Specifically, the inclination angle may be an obtuse angle. When the carrier 100 is located at the loading position 102, the contact portion 81224 is lifted by the carrier 100 to deform, and the second section of the elastic member 8122 abuts against the carrier 100.
In this embodiment, the moving direction of the carrier 100 is a direction along the connection between the second section and the first section of the elastic member 8122 and pointing to the end of the second section away from the first section. In this way, the carrier 100 can smoothly enter the lower surface of the second section under the guidance of the second section in the process of entering the sample adding position 102, and can not be propped against the end, far away from the first section, of the second section, and meanwhile, the carrier 100 can be smoothly removed from the lower surface of the second section after sample adding, and no interference can be generated.
In this embodiment, the limiting mechanism 812 further includes a fixing member 8124, the fixing member 8124 is fixedly connected to the substrate 10, and the elastic member 8122 is fixedly connected to the fixing member 8124 through the mounting portion 81222. Specifically, the contact portion 81224 of the elastic member 8122 is located below the fixing member 8124.
In this embodiment, referring to fig. 6, the second conveying device 40 includes a fifth driving member, a cam (not shown), and a conveying member 402, where the fifth driving member is configured to drive the cam to rotate, and further drive the conveying member 402 to move through a connecting rod, so as to drive the carrier 100 on the conveying member 402 to move to the pushing position 106. Specifically, a plurality of groups of spacing protrusions 404 are disposed on two sides of the conveying member 402, and the plurality of groups of spacing protrusions 404 are sequentially arranged at intervals. In this way, the carrier 100 may be positioned exactly between two adjacent sets of the positioning protrusions 404, ensuring that the carrier 100 is placed in order. In this embodiment, the fifth driving member is a motor.
In this embodiment, the second conveying device 40 further includes a first detector 406 corresponding to the pushing position 106, and when the first detector 406 detects that the carrier 100 is in the pushing position 106, the third conveying device 50 is started to push the carrier 100 onto the microscopy device 60.
In this embodiment, referring to fig. 7, the third conveying apparatus 50 includes a sixth driving member 502, a fourth conveying belt 504, a sliding block 506 and a pushing rod 508, where the sixth driving member 502, the sliding block 506 and the pushing rod 508 are all connected to the fourth conveying belt 504 and can be driven to move by the fourth conveying belt 504, and the sixth driving member 502 is used for pushing the sliding block 506 and the pushing rod 508 to move and rotate to drive the fourth conveying belt 504 to move, and is fixedly connected to the sliding block 506 and can move along with the sliding block 506, so as to push the carrier 100. When the pushing device works, the fourth conveying belt 504 drives the sixth driving piece 502 and the pushing rod 508 to move slowly, and after the fourth conveying belt 504 stops, the sixth driving piece 502 drives the pushing rod 508 to move quickly, so that the pushing at high speed and low speed is realized.
Specifically, the third conveying apparatus 50 further includes a mounting plate 510 and a guide rail 512 fixed to the mounting plate 510, and the sliding block 506 is slidably disposed on the guide rail 512, so as to be movable along the guide rail 512, so as to ensure the smoothness of the movement of the sliding block 506. Mounting plate 510 may be fixedly attached to base plate 10.
In this embodiment, referring to fig. 8 and 9, the microscopy platform 62 of the microscopy apparatus 60 includes a fixed plate 622, a sliding plate 624, a seventh driving member 625 for driving the sliding plate 624 to move along a first direction relative to the fixed plate 622, a moving plate 626, and an eighth driving member 627 for driving the moving plate 626 to move along a second direction relative to the sliding plate 624, and the microscopy position is disposed on the moving plate 626, so that the microscopy position can move along the first direction and the second direction. When the carrier 100 is located at the microscopic position, the sliding plate 624 and the moving plate 626 are driven to move along the first direction and the second direction, and the position of the lens 64 is adjusted to facilitate the lens 64 to capture images at a plurality of different positions, so that images of samples in a larger range are acquired for detection, and thus the captured images can relatively accurately drop to reflect the real situation of the samples, thereby improving the detection accuracy.
In this embodiment, the microscopy stage 62 further comprises a first connection plate 629 connecting the seventh driver 625 with the sliding plate 624 and a second connection plate 630 connecting the eighth driver 627 with the moving plate 626.
In this embodiment, referring to fig. 10, the microscopy stage 62 further includes a connection pad 632 connected to the moving plate 626 and a first conveying plate 634 connected to the connection pad 632, where the microscopy stage is located on the first conveying plate 634.
In this embodiment, a guiding chute 6342 is formed on the first conveying plate 634, a guiding sliding protrusion 6344 is disposed at the bottom of the guiding chute 6342, and a microscopic examination position is disposed in the guiding chute 6342. The arrangement of the sliding guide protrusion 6344 can reduce the contact area between the bottom of the sliding guide groove 6342 and the carrier 100, reduce friction, and reduce the dust accumulation probability at the top end of the sliding guide protrusion 6344, so as to improve the levelness of the object carrying device, reduce the levelness reduction of the microscopic examination platform 62 caused by dust accumulation, enable the carrier 100 not to be in the same focal length, greatly reduce the complicated operation of repeated focusing, and improve the use convenience of the microscopic examination device 60. In this embodiment, the sliding guide 6344 has two parallel protruding strips, and it is understood that other structures such as protruding points may be used for the sliding guide 6344.
In this embodiment, an inlet 6346 is provided at an end of the first conveying plate 634 near the third conveying device 50, where the inlet is trumpet-shaped, so that the carrier 100 can enter the inlet 6342 conveniently.
In this embodiment, the microscopy platform 62 further includes a pressing piece 636 disposed on the first conveying plate 634, where the pressing piece 636 is fixed outside the guide chute 6342 of the first conveying plate 634 and partially extends into the guide chute 6342, and a gap is left between the portion extending into the guide chute 6342 and the bottom of the guide chute 6342. When the carrier 100 is positioned in the guide chute 6342, the pressing piece 636 presses the carrier 100 to restrict the upward and downward movement of the carrier. Specifically, one pressing piece 636 is provided on each side of the guide chute 6342, thereby pressing both sides of the carrier 100. The position of the tab 636 corresponds to the microscopy position. By providing the pressing sheet 636, the carrier 100 can be pressed at the time of drawing, thereby preventing the carrier 100 from being unevenly placed due to moving inertia or dust on the track, and the like, so that images are not focused on the same layer at the time of drawing.
In this embodiment, the microscopy platform 62 further includes a first sensor 638 fixed to the fixed plate 622, a first sensor tab 639 fixed to the movable plate 626, a second sensor 640 fixed to the fixed plate 622, and a second sensor tab 642 fixed to the sliding plate 624, the first sensor 638 and the first sensor tab 639 being configured to sense whether the movable plate 626 moves to the original position in the second direction, and the second sensor 640 and the second sensor tab 642 being configured to sense whether the sliding plate 624 moves to the original position in the first direction. When one carrier 100 is detected and removed from the microscopy stage 62, the seventh and eighth driving units 625 and 627 are activated to drive the moving plate 626 and the sliding plate 624 to move, and the moving plate 626 and the sliding plate 624 are stopped when moved to the original position, the slide guide groove 6342 of the first conveying plate 634 is aligned with the third conveying device 50, and the third conveying device 50 is activated to push the carrier 100 of the pushing station 106 onto the first conveying plate 634. It will be appreciated that when it is desired to push the next carrier 100 to the microscopy position, the pusher 508 of the third conveying device 50 may be utilized to push the previous carrier 100 located in the microscopy position when the moving plate 626 and the sliding plate 624 are moved to the original position, and then the pusher 508 pushes the next carrier 100 to the microscopy position; it is also possible to push the next carrier 100 directly to the microscopy position while the next carrier 100 pushes the previous carrier 100 located in the microscopy position out during the movement, when the moving plate 626 and the sliding plate 624 are moved to the original position.
In this embodiment, the output position 108 is provided with a second conveying plate fixed to the substrate 10, and when the moving plate 626 and the sliding plate 624 move to the original positions, the second conveying plate is abutted with the first conveying plate 634.
Referring to fig. 1 again, in the present embodiment, the sample detection system further includes a waste device 90, the waste device 90 is disposed on one side of the microscopy stage 62, and the waste device 90 and the third conveying device 50 are respectively disposed on two sides of the microscopy stage 62. Specifically, the inspected carrier 100 located on the microscopy stage 62 is pushed to the waste device 90 by the third conveyor 50.
The sample detection method according to an embodiment of the present invention can utilize the sample detection system to perform sample detection, and includes the following steps:
S20: the third conveying device 50 conveys the carrier 100 to the microscopy position of the microscopy stage 62 of the microscopy device 60;
S22: moving the mirror position in a first direction and a second direction perpendicular to each other to adjust the relative position of the mirror position and the lens 64;
S24: moving the microscopy position in a first direction and a second direction perpendicular to each other to adjust the microscopy position to the original position, so that the third conveying means 50 is aligned with the microscopy position;
S28: the third conveyor 50 pushes the carrier 100 away from the microscopy position, thereby facilitating the third conveyor 50 to push the next carrier 100 to the microscopy position; or the third transport means 50 pushes the next said carrier 100 to the microscopy position while pushing the carrier previously located in the microscopy position away from the microscopy position by the next carrier.
The position of the lens 64 is adjusted during image acquisition, so that the lens 64 can acquire images of a large range of samples at different positions conveniently, and the acquired images can accurately reflect the real situation of the samples relatively, so that the detection accuracy is improved.
In this embodiment, the sample detection method further includes the step of, before step S20:
s12: the first transport device 30 transports the carrier 100 in the carrier storage device 20 to the loading position 102;
s14: loading the carrier 100 at the loading position 102;
s16: the first transport device 30 transports the loaded carrier 100 to the transfer station 104;
s18: the second conveyor 40 conveys the carriers 100 from the transfer station 104 to the push station 106.
In this embodiment, step S14 is specifically performed by the sample loading device 80, and the carrier 100 is pressed by the limiting mechanism 812 before loading, so as to prevent the carrier 100 from being lifted up in the process of retracting upwards after loading, and ensure that the sample loading device 80 is aligned with the carrier 100, thereby realizing accurate positioning of the carrier 100.
In this embodiment, the sample detection method further includes step S26, which is located before step S12: the carrier translation device 70 translates the carrier 100 within the carrier storage device 20 into alignment with the first conveyor 30.
The foregoing examples illustrate only a few embodiments of the invention and are described in detail herein without thereby limiting the scope of the invention. It should be noted that it will be apparent to those skilled in the art that several variations and modifications can be made without departing from the spirit of the invention, which are all within the scope of the invention. Accordingly, the scope of protection of the present invention is to be determined by the appended claims.
Claims (8)
1. The sample detection system is characterized by comprising a substrate, a microscopic examination device, a third conveying device and a waste device, wherein an output position is arranged on the substrate; the microscopic examination device comprises a microscopic examination platform and a lens, and the waste device and the third conveying device are respectively positioned at two sides of the microscopic examination platform;
the microscopic examination platform comprises a first conveying plate, a guide chute is formed in the first conveying plate, and a microscopic examination position of the microscopic examination platform is arranged in the guide chute;
the third conveying device is used for conveying the carrier to the microscopic examination position of the microscopic examination platform through the output position and the guide chute, the lens is used for picking up images of the carrier on the microscopic examination position, and the detected carrier on the microscopic examination platform is pushed to the waste device through the third conveying device;
The guide chute is provided with a first side wall, a second side wall and a bottom, wherein the first side wall and the second side wall are arranged at intervals along a first direction, the bottom is connected between the first side wall and the second side wall, the first side wall and the second side wall extend to the guide inlet, the conveying plate moves along a horizontal first direction relative to the microscopic examination platform so as to align the guide inlet with the output position, two convex strips which are arranged in parallel along the horizontal first direction are convexly arranged at the bottom of the guide chute along a vertical direction, and each convex strip extends from the guide inlet to the guide outlet of the guide chute far away from the guide inlet;
and a pressing sheet for pressing the carrier positioned at the microscopic examination position is arranged at the position of the microscopic examination platform corresponding to the microscopic examination position so as to limit the carrier positioned in the guide chute to move up and down.
2. The sample detection system of claim 1, wherein the microscopy stage comprises an eighth driver;
Wherein the eighth driving member drives the first conveying plate to move in a conveying direction perpendicular to the third conveying device.
3. The sample detection system according to claim 1, wherein the pressing piece is disposed on the first conveying plate, and the pressing piece is fixed outside the sliding guide groove of the first conveying plate and partially extends into the sliding guide groove, and a gap is left between the portion extending into the sliding guide groove and the bottom of the sliding guide groove.
4. The sample detection system of claim 3, wherein,
When the carrier is positioned in the microscopic examination position, the carrier is pressed between the pressing sheet and the convex strips.
5. The sample detection system according to claim 1, wherein the slide guide groove is further provided with a light transmission area, and the microscopic examination position is arranged corresponding to the light transmission area;
wherein, two the sand grip are located respectively the both sides of printing opacity district.
6. The sample detection system according to claim 1, wherein two sides of the guide chute are respectively provided with one of the pressing pieces.
7. The sample detection system according to claim 1, wherein a pushing position is further provided on the substrate, and the third conveying device is configured to convey a carrier from the pushing position to the microscopy position of the microscopy platform of the microscopy device through the output position and the guide chute;
The sample detection system further comprises a first detector arranged corresponding to the pushing position, and when the first detector detects that the pushing position has a carrier, the third conveying device is started to push the carrier to the microscopic examination device.
8. The sample detection system of any one of claims 1-7, wherein the third transport device is disposed on the substrate;
The third conveying device comprises a fourth conveying belt, a sixth driving piece, a sliding block and a pushing rod, wherein the sixth driving piece, the sliding block and the pushing rod are connected to the fourth conveying belt and driven to move by the fourth conveying belt, and the sixth driving piece is used for pushing the sliding block and the pushing rod to move.
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| CN202010268848.8A Active CN111413339B (en) | 2016-08-29 | 2016-08-29 | Microscopic examination device |
| CN202010269200.2A Active CN111413340B (en) | 2016-08-29 | 2016-08-29 | Sample adding device and sample detection system |
| CN202011215206.8A Active CN112326659B (en) | 2016-08-29 | 2016-08-29 | Sample detection system |
| CN202010282823.3A Active CN111413341B (en) | 2016-08-29 | 2016-08-29 | Sample detection system |
| CN202010268438.3A Pending CN111413337A (en) | 2016-08-29 | 2016-08-29 | Microscopic examination platform and microscopic examination device comprising same |
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| CN202011215206.8A Active CN112326659B (en) | 2016-08-29 | 2016-08-29 | Sample detection system |
| CN202010282823.3A Active CN111413341B (en) | 2016-08-29 | 2016-08-29 | Sample detection system |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4367915A (en) * | 1978-06-29 | 1983-01-11 | Georges Michael P | Automatic microscope slide |
| CN202110328U (en) * | 2011-03-24 | 2012-01-11 | 姚斌 | Full-automatic double charge coupled device (CCD) sensitization element digital microscope |
| CN103364237A (en) * | 2012-04-10 | 2013-10-23 | 深圳迈瑞生物医疗电子股份有限公司 | Glass slide processing device of smear dyeing machine |
Family Cites Families (59)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3434431A (en) * | 1965-12-27 | 1969-03-25 | Webb Co Jervis B | Stop for conveyor carriers |
| US4248498A (en) * | 1978-06-29 | 1981-02-03 | Georges Michael P | Automatic microscope slide |
| JPS59157535A (en) * | 1983-02-28 | 1984-09-06 | Sankyo Co Ltd | Automatic sample sealing system |
| US4499776A (en) * | 1983-03-04 | 1985-02-19 | Uhv Instruments Ltd. | Vacuum sample introduction unit |
| CA2227177A1 (en) * | 1995-07-19 | 1997-02-06 | Morphometrix Technologies Inc. | Automated scanning of microscope slides |
| AU715627B2 (en) * | 1996-02-21 | 2000-02-03 | Biomerieux Vitek, Inc. | Automatic sample testing machine |
| JPH1022371A (en) * | 1996-07-03 | 1998-01-23 | Nippon Telegr & Teleph Corp <Ntt> | Sample fixing apparatus |
| JPH10327346A (en) * | 1997-05-27 | 1998-12-08 | Canon Inc | Film holder and device using the film holder |
| JP3194893B2 (en) * | 1997-07-17 | 2001-08-06 | アロカ株式会社 | Slide glass holder |
| US6262838B1 (en) * | 1998-03-20 | 2001-07-17 | Genetic Microsystems Inc | Focusing in microscope systems |
| DE10143803A1 (en) * | 2001-09-06 | 2003-03-27 | Leica Microsystems | Label imprinting apparatus for e.g. cassettes, has pivot device for aligning printing head with differently inclined printing planes, or vice versa |
| US6847481B1 (en) * | 2001-10-26 | 2005-01-25 | Ludl Electronics Products, Ltd. | Automated slide loader cassette for microscope |
| JP4235171B2 (en) * | 2002-05-17 | 2009-03-11 | ジェン−プロウブ インコーポレイテッド | Sample carrier with sample tube blocking means and drip shield for use therewith |
| JP2005101342A (en) * | 2003-09-25 | 2005-04-14 | Fuji Mach Mfg Co Ltd | Electronic circuit component mounting system |
| US6905300B1 (en) * | 2004-01-16 | 2005-06-14 | Dmetrix, Inc. | Slide feeder with air bearing conveyor |
| WO2008019311A2 (en) * | 2006-08-04 | 2008-02-14 | Ikonisys, Inc. | Automated cassette and slide handling system for an automatic microscope |
| KR100769851B1 (en) * | 2006-11-09 | 2007-10-24 | (주)휴맥 | Leadframe Automatic Packaging Device |
| CN100500861C (en) * | 2007-02-02 | 2009-06-17 | 杭州浙大优创科技有限公司 | Microscope detection device of direct microscopy method for milk somatic cell/bacteria of automatic calculating instrument and microscope focusing method |
| CN101086496B (en) * | 2007-07-16 | 2012-05-23 | 山东优生医疗科技有限公司 | Full-automatic blood conventional intelligent analyzer and analysis method thereof |
| DE102007042138A1 (en) * | 2007-09-05 | 2009-03-12 | Carl Zeiss Microimaging Gmbh | Method and device for automatic sample feeding |
| KR101076076B1 (en) * | 2009-09-28 | 2011-10-21 | 현대제철 주식회사 | A holder apparatus for specimen in scanning elctron microscope |
| CN201780226U (en) * | 2010-08-30 | 2011-03-30 | 深圳华大基因科技有限公司 | Chromosome specimen dropping device |
| CN102338807B (en) * | 2010-12-01 | 2013-04-24 | 北京赛尔蒂扶科技发展有限公司 | Full automatic conveying device suitable for batch microscopic examination of glass slides |
| CN201980758U (en) * | 2011-01-07 | 2011-09-21 | 罗斌 | Automatic feeding device for slide glass of microscope for examination |
| DE102011009502B4 (en) * | 2011-01-26 | 2017-11-02 | Leica Biosystems Nussloch Gmbh | Covering module for applying coverslips to slides |
| CN102122065B (en) * | 2011-03-24 | 2013-01-23 | 姚斌 | Microscopic slide automatic feeding device |
| CN202083828U (en) * | 2011-05-05 | 2011-12-21 | 京隆科技(苏州)有限公司 | Improved structure of microscope carrier |
| CN202389966U (en) * | 2011-11-22 | 2012-08-22 | 恽嘉宝 | Automatic feeding and inspecting machine for glass slides of microscopes |
| CN202471484U (en) * | 2012-03-09 | 2012-10-03 | 北京建筑工程学院 | Glass slide clamping device |
| CN103115807A (en) * | 2012-07-17 | 2013-05-22 | 上海聚阵生物科技有限公司 | Biochip sample application instrument |
| AU2013370575B2 (en) * | 2012-12-26 | 2016-05-26 | Ventana Medical Systems, Inc. | Automated specimen processing systems and methods of aligning and transporting specimen-bearing microscope slides |
| US9989448B2 (en) * | 2012-12-26 | 2018-06-05 | Ventana Medical Systems, Inc. | Specimen processing systems and methods for holding slides |
| CN103072944A (en) * | 2013-01-10 | 2013-05-01 | 中国计量科学研究院 | Clamping mechanism |
| CN203117207U (en) * | 2013-02-04 | 2013-08-07 | 爱威科技股份有限公司 | Multi-module microscopic examination detecting system |
| DE102013205001B3 (en) * | 2013-03-21 | 2014-05-28 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Arrangement for optical detection of sections, particularly sample region on sample, has inspection unit formed for optical detection of sample region, where inspection unit comprises microscope |
| CN203133097U (en) * | 2013-03-26 | 2013-08-14 | 山东博科生物产业有限公司 | Automatic sample loading mechanism |
| CN104569451B (en) * | 2013-10-15 | 2017-02-01 | 深圳迈瑞生物医疗电子股份有限公司 | Sample rack transporting and distributing device and sample rack transporting and distributing method |
| CN104713858B (en) * | 2013-12-11 | 2017-08-04 | 苏州新波生物技术有限公司 | Full-automatic Time-resolved fluorescence assay device and application method |
| CN203587877U (en) * | 2013-12-17 | 2014-05-07 | 吉林大学 | Microscope fast focusing objective table device |
| CN103676127B (en) * | 2013-12-31 | 2015-03-11 | 爱威科技股份有限公司 | Supporting device for microscope, microscope and microscope carrier |
| CN203753896U (en) * | 2014-02-27 | 2014-08-06 | 三峡大学 | Mixed powder quantitative conveying and flattening device |
| CN203732338U (en) * | 2014-03-08 | 2014-07-23 | 相寿敏 | Portable smear making box |
| CN103922174A (en) * | 2014-04-11 | 2014-07-16 | 昆山市兴凯胜精密模具有限公司 | Feeding mechanism |
| CN104199181A (en) * | 2014-07-21 | 2014-12-10 | 张波 | Full-automatic inspection microscope system |
| CN204036584U (en) * | 2014-08-25 | 2014-12-24 | 鹤山市址山镇东升恒机械厂 | A kind of hot-press arrangement and loader thereof |
| CN204008675U (en) * | 2014-08-27 | 2014-12-10 | 爱威科技股份有限公司 | A kind of sample feeding mechanism |
| CN104181316B (en) * | 2014-08-28 | 2018-04-27 | 爱威科技股份有限公司 | A kind of multinomial detection device of sample and method |
| CN104259334A (en) * | 2014-09-30 | 2015-01-07 | 成都市翻鑫家科技有限公司 | Unidirectional rotation type material strap reciprocating pushing mechanism |
| CN204229044U (en) * | 2014-10-22 | 2015-03-25 | 神华集团有限责任公司 | A kind of microscope |
| CN104503073B (en) * | 2014-12-19 | 2017-07-04 | 爱威科技股份有限公司 | Microscope and its drive device |
| CN104588335A (en) * | 2014-12-31 | 2015-05-06 | 深圳市海恒智能技术有限公司 | Goods sorting system and self-service book-returning machine for library |
| CN105092582A (en) * | 2015-08-07 | 2015-11-25 | 苏州合惠生物科技有限公司 | Large-visual-field microscopic examination device and method for full-automatic immunohistochemistry |
| CN205451274U (en) * | 2015-09-15 | 2016-08-10 | 嘉兴职业技术学院 | Automatic vending machine |
| CN205091167U (en) * | 2015-10-16 | 2016-03-16 | 董爱玲 | Clinical examination branch of academic or vocational study slide glass preparation platform |
| CN205067857U (en) * | 2015-10-29 | 2016-03-02 | 深圳市同盛医疗设备有限公司 | Slide glass bracket and microscope |
| CN205262831U (en) * | 2015-12-12 | 2016-05-25 | 杭州海世嘉生物科技有限公司 | Natural sedimentation formula cell slice -making and dyeing machine |
| CN205492815U (en) * | 2016-04-14 | 2016-08-24 | 温州意迈达鞋业有限公司 | Shoemaking machinery's conveyer |
| CN206146950U (en) * | 2016-08-29 | 2017-05-03 | 爱威科技股份有限公司 | Sample feeding device and sample test system |
| CN107782726B (en) * | 2016-08-29 | 2020-11-27 | 爱威科技股份有限公司 | Sample detection system and sample detection method |
-
2016
- 2016-08-29 CN CN201610750374.4A patent/CN107782726B/en active Active
- 2016-08-29 CN CN202010268674.5A patent/CN111413338B/en active Active
- 2016-08-29 CN CN202010268848.8A patent/CN111413339B/en active Active
- 2016-08-29 CN CN202010269200.2A patent/CN111413340B/en active Active
- 2016-08-29 CN CN202011215206.8A patent/CN112326659B/en active Active
- 2016-08-29 CN CN202010282823.3A patent/CN111413341B/en active Active
- 2016-08-29 CN CN202010268438.3A patent/CN111413337A/en active Pending
- 2016-08-29 CN CN202011216057.7A patent/CN112326660B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4367915A (en) * | 1978-06-29 | 1983-01-11 | Georges Michael P | Automatic microscope slide |
| CN202110328U (en) * | 2011-03-24 | 2012-01-11 | 姚斌 | Full-automatic double charge coupled device (CCD) sensitization element digital microscope |
| CN103364237A (en) * | 2012-04-10 | 2013-10-23 | 深圳迈瑞生物医疗电子股份有限公司 | Glass slide processing device of smear dyeing machine |
Also Published As
| Publication number | Publication date |
|---|---|
| CN112326660B (en) | 2024-01-02 |
| CN111413338A (en) | 2020-07-14 |
| CN107782726A (en) | 2018-03-09 |
| CN112326659B (en) | 2024-04-26 |
| CN111413340B (en) | 2024-05-28 |
| CN111413340A (en) | 2020-07-14 |
| CN111413339A (en) | 2020-07-14 |
| CN111413341A (en) | 2020-07-14 |
| CN112326659A (en) | 2021-02-05 |
| CN112326660A (en) | 2021-02-05 |
| CN111413339B (en) | 2023-06-09 |
| CN107782726B (en) | 2020-11-27 |
| CN111413341B (en) | 2024-11-08 |
| CN111413337A (en) | 2020-07-14 |
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