CN111281624A - Tumor heat ablation biliary tract metal stent under magnetic field and manufacturing method thereof - Google Patents
Tumor heat ablation biliary tract metal stent under magnetic field and manufacturing method thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
- A61F2/90—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
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- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
- A61F7/12—Devices for heating or cooling internal body cavities
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- A—HUMAN NECESSITIES
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- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
- A61F7/12—Devices for heating or cooling internal body cavities
- A61F2007/126—Devices for heating or cooling internal body cavities for invasive application, e.g. for introducing into blood vessels
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
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Abstract
The invention discloses a tumor thermal ablation biliary tract metal stent under a magnetic field and a manufacturing method thereof. The device provided by the invention has two functions: firstly, dilating the stenotic bile duct and relieving the jaundice symptom of the patient; secondly, the medicine has the function of thermal ablation and kills local tumor tissues. The method provides treatment opportunities for patients with end-stage extrahepatic bile duct tumors without operation opportunities and extrahepatic bile duct tumors which cannot be treated by operation, does not need surgery, eliminates local tumors, improves the survival quality of the patients and prolongs the life cycle. The human tissue does not produce adverse reactions such as allergic stimulation and the like. According to the monitoring of the disease change and the tumor recurrence of the patient, the treatment can be carried out for a plurality of times, and the life cycle of the patient is greatly prolonged.
Description
Technical Field
The invention belongs to the field of biliary stents, and particularly relates to a biliary stent for tumor thermal ablation under a magnetic field and a manufacturing method thereof.
Background
Scientific research finds that no matter what kind of cancer cells are not high-temperature resistant, and tumor tissues can be damaged and withered when the normal tissue cells of a human body can still tolerate high temperature. The temperature in the tumor tissue is usually 5-10 ℃ higher than that of the adjacent normal tissue after the human body is heated, and when the temperature of the tumor body reaches more than 41 ℃ and is maintained for a certain time, the cancer cells can be killed. Normal tissue can tolerate 46 ℃ without irreversible damage due to its good thermoregulatory system and tolerance. But the human body itself cannot sustain temperatures above 41 degrees celsius for a long time. Human normal tissue is at the body temperature, under the circumstances of rising, vasodilatation, the blood flow is with higher speed, because this kind of regulatory action of organism, guaranteed when the body temperature rises, even when reaching 41.5 ~ 43 ℃, normal cell tissue is not damaged, however tumour tissue is then not so, and blood vessel form is unusual in the tumour, and mixed and disorderly distortion, easily receive pressure deformation form thrombus or embolism. In addition, the blood vessels in the tumor are mostly composed of monolayer cells, and are fragile and easy to break. Because these new vessels are abnormal vessels which are not developed completely, the self-regulation function is lost after the new vessels are heated, the veins can not accelerate the reflux, the local blood sedimentation of the tumor is stagnated, and the blood flow is only 1 to 15 percent of that of the normal tissue, so that the tumor tissue is difficult to dissipate heat, and the temperature is increased. The temperature of malignant tumor tissue is usually 8-10 ℃ higher than that of normal adjacent tissue. Local heating is also carried out, if the temperature of normal tissues is raised to 40 ℃, the temperature in the tumor body can be raised to about 48 ℃, and the temperature is enough to cause the tumor cells to be heated and killed, while the normal tissues are not damaged.
Induction heating is performed by heating a conductor itself by an induced current (eddy current loss) generated by the conductor under the action of a high-frequency magnetic field and by the action of a magnetic field in the conductor (hysteresis loss).
When the metal conductor is in a high-frequency alternating electric field, induced electromotive force is generated in the metal conductor according to the Faraday's law of electromagnetic induction, and strong induced current is generated due to the small resistance of the conductor. According to Joule-Lenz law, the alternating magnetic field enables current in the conductor to flow towards the surface of the conductor to cause a skin effect, the density of the current is in direct proportion to the frequency, the higher the frequency is, the induced current density is concentrated on the surface of the conductor, namely the skin effect is more serious, the effective conducting area is reduced, the resistance is increased, and therefore the temperature of the conductor is rapidly increased.
When a current flows through the conductor, a magnetic field is simultaneously generated around the conductor, and a high-frequency current flows to an inductance coil wound in a ring shape or other shapes. Thus, a strong magnetic flux whose polarity is instantaneously changed is generated in the coil, and the metal material to be heated is placed in the induction coil, so that the magnetic flux penetrates the entire material to be heated, a large eddy current is generated in the material to be heated in a direction opposite to the heating current, and joule heat is generated by the resistance of the metal material to be heated, thereby rapidly raising the temperature of the metal material itself.
The proceedings of the national academy of sciences, U.S. 6 months 2004 reported significant progress made by a research group at the university of rice, usa: they designed and manufactured gold-plated nanoshells that could find and kill malignant tumor cells and have been successful in laboratory mice. The nanoshell is cored with a non-conductive silica particle having a diameter of 110 nm and coated with a 10 nm thick metal shell. Researchers first "ship" the nanoshells into cancerous tissue and then irradiate the cancerous tissue with near infrared light from outside the body. When the near infrared ray passes through normal tissues of a human body to reach the canceration tissues, the near infrared ray can be absorbed by the nano bullet buried in the canceration tissues. As the absorption increases, the temperature of the nanobullet begins to rise, resulting in the surrounding cancerous tissue warming and dying.
The German Berlin "sarilt" clinical hospital tries to treat cancer by means of magnetic nanoparticles and obtains better curative effect in animal experiments. Researchers in this hospital use magnetic nanoparticles to treat cancer: a number of extremely fine iron oxide nanoparticles are injected into a patient's tumor, and the patient is then placed in a variable magnetic field. Under the influence of the magnetic field, the temperature of the iron oxide nanoparticles in the patient's tumor is raised to 45 to 47 degrees centigrade, which is sufficient to burn out the cancer cells. Since there are no magnetic particles in the body tissue near the tumor, the temperature of these healthy tissues will not rise and be harmed.
The number of cases of obstructive jaundice caused by tumors increases year by year, and for patients who cannot be operated, the most common treatment method at present is to place a biliary tract metal stent to relieve obstruction symptoms and improve the survival quality of the patients. However, cases of recurrence of postoperative jaundice still occur frequently. The main reason for this is that the bile duct can be expanded in a short period after the used metal bare stent is implanted, a smooth passage is formed, but with the development of the tumor, the tumor tissue climbs towards the edge along the stent and grows in the meshes, so that the bile duct is restenosis, bile drainage is blocked, and jaundice reappears. In order to solve the problem of biliary stent restenosis, the following solutions are available in the industry: one is that the metal stent is externally coated with polyurethane, which can prevent the tumor from growing inside through meshes, but can not solve the problem that the tumor tissue blocks the stent port by climbing and spreading growth and the tumor grows and extrudes the stent restenosis. One is a drug-loaded stent graft, which has pharmacological side effects on normal cells without metastasis of cancer cells. One is a covered stent which can carry radioactive particles and can generate negative effect on normal cells of a human body. Meanwhile, the indwelling biliary duct stent causes water, electricity, acid and alkali disorder, dyspepsia and drainage mouth infection.
Disclosure of Invention
In view of the above-mentioned technical problems, a magnetic field tumor thermal ablation biliary tract metal stent and a manufacturing method thereof are provided. The technical means adopted by the invention are as follows:
the utility model provides a tumour heat ablation biliary tract metal support under magnetic field, includes the support main part, the support main part is formed by the wire winding processing that has elasticity and can be adsorbed by magnetism, be equipped with a plurality of recesses on the outer wall of main part support, just be equipped with iron oxide solid particle in the recess, just main part support surface parcel has insulating heat conduction silica gel layer.
The metal wire is made of alloy material including high elastic steel, stainless steel or titanium alloy.
A method for manufacturing a biliary tract metal stent for tumor thermal ablation under a magnetic field comprises the following steps:
s1: winding and processing a metal wire made of alloy material comprising high-elasticity steel, stainless steel or titanium alloy into a bracket main body;
s2: corroding the stent main body by using an acid solution to form a certain number of grooves on the outer surface of the stent body;
s3: placing the corroded stent body in iron oxide solid particles or uniformly scattering the iron oxide solid particles on the outer surface of the stent body, attaching the iron oxide solid particles to the outer surface of the stent body by utilizing the magnetism of the iron oxide solid particles, wiping off the iron oxide solid particles on the surface layer, and then keeping the iron oxide solid particles in the grooves;
s4: and the outside of the stent body is wrapped by an insulating heat-conducting silica gel layer to form the tumor heat ablation biliary tract metal stent under a magnetic field.
In the use state: the heat ablation biliary tract metal stent is placed at a biliary tract tumor part through an ERCP (duodenoscope technology) and a stent pushing device, the stent recovers the original shape, and the biliary tract is supported by the strength and elasticity of metal. The human body is placed in a magnetic field of a high-frequency induction generator, the position of the heat ablation biliary tract metal stent is aligned with the center of the magnetic field, the high-frequency induction generator is controlled by a controller to generate the high-frequency magnetic field, the stent main body and the ferric oxide solid particles generate eddy currents through the change of the high-frequency magnetic field, so that joule heat is generated, the temperature of the metal stent is rapidly increased, and cancer cells near the stent supporting position are heated, so that the cancer cells are damaged.
Because the support main body and the ferric oxide solid particles generate eddy current under the action of a magnetic field in a high-frequency magnetic field, the silica gel material has an insulating effect. In addition, the different constitutions of the human body generate allergy and other adverse reactions caused by the stimulation of the metal stent, and the embodiment utilizes the excellent biocompatibility characteristic of the silica gel and the human tissue, and does not generate any stimulation allergic reaction with cells. Meanwhile, the insulating layer can be deformed along with the deformation of the titanium alloy support by utilizing the soft characteristic of the silica gel material, so that the insulating layer cannot be damaged.
The invention solves the industrial problem that the development of cancer cells needs an operation, does not need the operation, avoids secondary damage to patients and improves the life quality of the patients. Meanwhile, the biological gel has excellent biocompatibility, and human tissues can not generate adverse reactions such as allergic stimulation and the like. Through duodenoscope and radiography reexamination, the bile duct unobstructed condition and the tumor recurrence condition are monitored, repeated treatment can be carried out, and the life cycle of the patient is greatly prolonged.
For the reasons, the invention can be widely popularized in the fields of biliary stents and the like.
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly introduced below, and it is obvious that the drawings in the following description are some embodiments of the present invention, and for those skilled in the art, other drawings can be obtained according to these drawings without creative efforts.
Fig. 1 is a schematic structural diagram of a biliary tract metal stent for tumor thermal ablation under a magnetic field according to an embodiment of the present invention.
FIG. 2 is a schematic structural diagram of a stent body according to an embodiment of the present invention.
Fig. 3 is an enlarged view of a portion B in fig. 2.
Fig. 4 is a sectional view taken along line a-a in fig. 1.
Detailed Description
In order to make the objects, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are some, but not all, embodiments of the present invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Example 1
As shown in fig. 1 to 4, a metal stent for tumor thermal ablation of biliary tract under a magnetic field comprises a stent main body 1, wherein the stent main body 1 is formed by winding and processing a metal wire which has elasticity and can be magnetically adsorbed, a plurality of grooves 2 are formed on the outer wall of the main body stent 1, iron oxide solid particles 3 are arranged in the grooves 2, and an insulating and heat-conducting silica gel layer 4 wraps the surface of the main body stent 1.
The metal wire is made of alloy material including high elastic steel, stainless steel or titanium alloy.
Example 2
As shown in fig. 1 to 4, a method for manufacturing a biliary tract metal stent for tumor thermal ablation under a magnetic field comprises the following steps:
s1: a metal wire 5 made of alloy material including high elastic steel, stainless steel or titanium alloy is wound and processed into a stent main body 1;
s2: corroding the stent main body 1 by using an acid solution to form a certain number of grooves 2 on the outer surface of the stent main body 1;
s3: placing the corroded stent body 1 in iron oxide solid particles 3 or uniformly scattering the iron oxide solid particles 3 on the outer surface of the stent body 1, attaching the iron oxide solid particles 3 to the outer surface of the stent body 1 by utilizing the magnetism of the iron oxide solid particles 3, wiping off the iron oxide solid particles 3 on the surface layer, and then keeping the iron oxide solid particles 3 in the grooves 2;
s4: the bracket body 1 is wrapped by an insulating heat-conducting silica gel layer 4 to form the tumor heat ablation biliary tract metal bracket under a magnetic field.
Finally, it should be noted that: the above embodiments are only used to illustrate the technical solution of the present invention, and not to limit the same; while the invention has been described in detail and with reference to the foregoing embodiments, it will be understood by those skilled in the art that: the technical solutions described in the foregoing embodiments may still be modified, or some or all of the technical features may be equivalently replaced; and the modifications or the substitutions do not make the essence of the corresponding technical solutions depart from the scope of the technical solutions of the embodiments of the present invention.
Claims (3)
1. The utility model provides a tumour heat ablation biliary tract metal support under magnetic field, includes the support main part, its characterized in that: the support body is formed by winding and processing metal wires which have elasticity and can be magnetically adsorbed, a plurality of grooves are formed in the outer wall of the main body support, iron oxide solid particles are arranged in the grooves, and the surface of the main body support is wrapped with an insulating heat-conducting silica gel layer.
2. The metal stent for tumor thermal ablation of biliary tract under magnetic field according to claim 1, wherein: the metal wire is made of alloy material including high elastic steel, stainless steel or titanium alloy.
3. A method for manufacturing a biliary tract metal stent for tumor thermal ablation under a magnetic field is characterized by comprising the following steps:
s1: winding and processing a metal wire made of alloy material comprising high-elasticity steel, stainless steel or titanium alloy into a bracket main body;
s2: corroding the stent main body by using an acid solution to form a certain number of grooves on the outer surface of the stent body;
s3: placing the corroded stent body in iron oxide solid particles or uniformly scattering the iron oxide solid particles on the outer surface of the stent body, attaching the iron oxide solid particles to the outer surface of the stent body by utilizing the magnetism of the iron oxide solid particles, wiping off the iron oxide solid particles on the surface layer, and then keeping the iron oxide solid particles in the grooves;
s4: and the outside of the stent body is wrapped by an insulating heat-conducting silica gel layer to form the tumor heat ablation biliary tract metal stent under a magnetic field.
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| CN202010153633.1A CN111281624A (en) | 2020-03-06 | 2020-03-06 | Tumor heat ablation biliary tract metal stent under magnetic field and manufacturing method thereof |
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| CN202010153633.1A CN111281624A (en) | 2020-03-06 | 2020-03-06 | Tumor heat ablation biliary tract metal stent under magnetic field and manufacturing method thereof |
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Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20080071353A1 (en) * | 2006-09-15 | 2008-03-20 | Boston Scientific Scimed, Inc. | Endoprosthesis containing magnetic induction particles |
| US20090005850A1 (en) * | 2007-06-29 | 2009-01-01 | Boston Scientific Scimed, Inc. | Molybdenum Endoprostheses |
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| US20080071353A1 (en) * | 2006-09-15 | 2008-03-20 | Boston Scientific Scimed, Inc. | Endoprosthesis containing magnetic induction particles |
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| CN102379762A (en) * | 2011-08-02 | 2012-03-21 | 微创医疗器械(上海)有限公司 | Biodegradable stent with groove and preparation method thereof |
| US20190111187A1 (en) * | 2017-10-16 | 2019-04-18 | Medtronic Vascular, Inc. | Therapeutic nanoparticles for treating vascular diseases |
| CN209236465U (en) * | 2018-11-09 | 2019-08-13 | 焦德超 | It is a kind of for carrying the bracket of radioactive particle and tumor suppressor |
| CN211962289U (en) * | 2020-03-06 | 2020-11-20 | 大连医科大学附属第一医院 | Tumor heat ablation biliary tract metal stent under magnetic field |
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