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CN111249289A - Oral care product or medicament for anti-inflammation and/or anti-allergy - Google Patents

Oral care product or medicament for anti-inflammation and/or anti-allergy Download PDF

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Publication number
CN111249289A
CN111249289A CN202010093186.5A CN202010093186A CN111249289A CN 111249289 A CN111249289 A CN 111249289A CN 202010093186 A CN202010093186 A CN 202010093186A CN 111249289 A CN111249289 A CN 111249289A
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China
Prior art keywords
oral care
care product
toothpaste
medicament
saponin
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Pending
Application number
CN202010093186.5A
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Chinese (zh)
Inventor
苏柘僮
赵俊卿
杨世林
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Guangxi Yingluweite Pharmaceutical Co Ltd
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Guangxi Yingluweite Pharmaceutical Co Ltd
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Priority to CN202010093186.5A priority Critical patent/CN111249289A/en
Publication of CN111249289A publication Critical patent/CN111249289A/en
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/60Sugars; Derivatives thereof
    • A61K8/602Glycosides, e.g. rutin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/20Chemical, physico-chemical or functional or structural properties of the composition as a whole
    • A61K2800/28Rubbing or scrubbing compositions; Peeling or abrasive compositions; Containing exfoliants

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Birds (AREA)
  • Hematology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Cosmetics (AREA)

Abstract

The invention provides an anti-inflammatory and/or anti-allergic oral care product or medicine, which comprises pulsatilla saponin B4. The invention also provides application of the pulsatilla saponin B4 in preparing anti-inflammatory and/or anti-allergic oral care products or medicines. The experimental result shows that the pulsatilla saponin B4 is added into the oral care product, so that the inflammation, pain and inflammation of the gum can be treated, the bleeding symptom of the gum can be treated, and the anti-inflammation and anti-allergy effects of the oral care product can be obviously improved in a short time. Therefore, the pulsatilla saponin B4 has a very good application prospect in preparing oral care products or medicines for diminishing inflammation and resisting allergy by being used as an active ingredient.

Description

Oral care product or medicament for anti-inflammation and/or anti-allergy
Technical Field
The invention belongs to the field of medicines, and particularly relates to an anti-inflammatory and/or anti-allergic oral care product or medicine.
Background
In China, 90% of adults have oral problems of different degrees, professional medical statistical data show that with the change of eating habits and the increase of working pressure, oral problems such as oral ulcer, tooth openness and swelling pain, bleeding and atrophy are spreading rapidly, and meanwhile, common oral diseases such as gingivitis, periodontitis and alveolar abscess caused by chemical drugs, burns, vitamin C deficiency, bacterial growth in oral cavities and the like are increasing.
In order to prevent or alleviate the above oral problems in daily life, there are commercially available oral care products such as antiallergic toothpaste, anti-inflammatory mouth wash, etc. which are full of precious minerals. However, most of the existing functional oral care products only have a single nursing effect, and are difficult to truly play the roles of diminishing inflammation and resisting allergy at the same time. Moreover, most of the existing functional oral care products have the problems of complex components, slow effect and unobvious effect, and can not meet the requirements of consumers.
Therefore, a new product capable of nursing the oral cavity quickly and variously is developed, and the novel oral cavity nursing device has a very good prospect.
Disclosure of Invention
The object of the present invention is to provide a new anti-inflammatory and/or anti-allergic oral care product or medicament.
The invention provides an anti-inflammatory and/or anti-allergic oral care product or medicine, which comprises pulsatilla saponin B4.
Furthermore, in the oral care product or the medicine, the weight ratio of the pulsatilla saponin B4 is more than 0.5 per thousand.
Furthermore, in the oral care product or the medicine, the weight ratio of the pulsatilla saponin B4 is 0.5-1 per thousand.
Further, the oral care product is a toothpaste or a mouthwash.
Further, the toothpaste is prepared from the pulsatilla saponin B4 and other components, wherein the other components comprise an abrasive, a humectant, a foaming agent, a binder, a spice, a sweetener, a preservative and water;
preferably, the friction agent is calcium carbonate, the humectant is sorbitol, the foaming agent is sodium lauryl sulfate, the binder is sodium carboxymethylcellulose, the sweetener is saccharin, and the preservative is ethylparaben.
Further, in the rest of the components, the content of the abrasive is 37.0-41.0 wt.%, preferably 39.0 wt.%; the humectant content is 20.0-24.0 wt.%, preferably 22.0 wt.%; the content of the foaming agent is 1.0-1.5 wt.%, preferably 1.3 wt.%; the content of the adhesive is 1.0-1.2 wt.%, preferably 1.1 wt.%; the perfume content is 0.8-1.2 wt.%, preferably 1.0 wt.%; the content of the sweetening agent is 0.05-0.15 wt.%, preferably 0.10 wt.%; the content of the preservative is less than 0.3 wt.%; the remainder was water.
The invention also provides application of the pulsatilla saponin B4 in preparing anti-inflammatory and/or anti-allergic oral care products or medicines.
Furthermore, in the oral care product or the medicine, the weight ratio of the pulsatilla saponin B4 is more than 0.5 per thousand, and preferably 0.5 to 1 per thousand.
Further, the oral care product is a toothpaste or a mouthwash.
Further, the oral care product or medicament is capable of treating inflammation, pain, redness and/or bleeding of the gums.
The structure of the pulsatilla saponin B4 is as follows:
Figure BDA0002384402120000021
the experimental result shows that the pulsatilla saponin B4 is added into the toothpaste or the mouthwash to treat the symptoms of inflammation, pain and red swelling of the gum and the bleeding of the gum, and the anti-inflammatory and anti-allergic effects of the toothpaste or the mouthwash are remarkably improved in a short time. Therefore, the pulsatilla saponin B4 has a very good application prospect in preparing anti-inflammatory and/or anti-allergic oral care products by being used as an active ingredient.
Obviously, many modifications, substitutions, and variations are possible in light of the above teachings of the invention, without departing from the basic technical spirit of the invention, as defined by the following claims.
The present invention will be described in further detail with reference to the following examples. It should not be understood that the scope of the above-described subject matter of the present invention is limited to the following examples. All the technologies realized based on the above contents of the present invention belong to the scope of the present invention.
Detailed Description
The raw materials and equipment used in the invention are known products and are obtained by purchasing commercial products.
Wherein, the pulsatilla saponin B4 (purity is more than 99.5%) is obtained by purchase.
EXAMPLE 1 preparation of a mouthwash according to the invention
Adding the pulsatilla chinensis saponin B4 into physiological saline, uniformly mixing, and controlling the weight ratio of pulsatilla chinensis saponin B4 to be 0.5 per thousand or 1 per thousand of the total weight to respectively obtain 0.5 per thousand or 1 per thousand of mouthwash of the invention.
Example 2 preparation of a toothpaste according to the invention
Adding the pulsatilla chinensis saponin B4 into the untreated toothpaste, and uniformly mixing, wherein the weight ratio of the pulsatilla chinensis saponin B4 is controlled to be 0.5 per thousand or 1 per thousand of the total weight, so as to respectively obtain 0.5 per thousand toothpaste or 1 per thousand toothpaste.
Wherein the untreated toothpaste is a regular toothpaste prepared from calcium carbonate (39.0 wt.%), sorbitol (22.0 wt.%), sodium carboxymethylcellulose (1.1 wt.%), sodium lauryl sulfate (1.3 wt.%), saccharin (0.1 wt.%), perfume (1.0 wt.%), ethylparaben (less than 0.3 wt.%) and deionized water.
The beneficial effects of the present invention are demonstrated by the following experimental examples.
Experimental example 1 anti-inflammatory Effect test of toothpaste according to the present invention
(1) Test objects: randomly taking 15 patients from the patient sample; symptoms are: inflammation, pain, redness and swelling of the gums.
(2) Test samples: 0.5 per mill toothpaste and 1 per mill toothpaste prepared in the embodiment 2 of the invention; commercially available anti-inflammatory toothpaste (gaolujie).
(3) The experimental method comprises the following steps: the patients were randomly divided into 3 groups, the first group was used for brushing teeth with commercially available anti-inflammatory toothpaste, the second group was used for brushing teeth with 0.5 ‰ toothpaste, and the third group was used for brushing teeth with 1 ‰ toothpaste for 2 times per day, with the toothpaste amount of 2cm each time and the tooth brushing time of 5min each time. And observing the recovery condition and the recovery time of the gum of the patient.
The healing standard is as follows: the gum pain disappeared and the redness and swelling subsided.
(4) Results of the experiment
The results are shown in table 1, on the 3 rd day of the experiment, no obvious anti-inflammatory effect is achieved after the commercial toothpaste is used, but the pain of the patient is weakened after the 0.5 per mill toothpaste is used, the red swelling of the patient is relieved after the 1 per mill toothpaste is used, and the anti-inflammatory effect is obvious. The toothpaste can cure inflammation, pain and swelling of the gum of a patient within 5 days, the anti-inflammation effect of the toothpaste is superior to that of the commercially available anti-inflammation toothpaste, and the anti-inflammation effect of 1 per mill of the toothpaste is superior to that of 0.5 per mill of the toothpaste.
The experiments show that the anti-inflammatory effect of the toothpaste can be obviously improved by adding the pulsatilla saponin into the toothpaste, and the anti-inflammatory effect is enhanced along with the increase of the addition amount of the pulsatilla saponin.
TABLE 1 comparison of anti-inflammatory effects
Figure BDA0002384402120000031
Experimental example 2 antiallergic effect test of toothpaste of the present invention
(1) Test objects: randomly taking 15 patients from the patient sample; symptoms are: the gum is prone to bleeding and sensitive to cold and heat.
(2) Test samples: 0.5 per mill toothpaste and 1 per mill toothpaste prepared in the embodiment 2 of the invention; commercially available anti-allergic toothpaste (gaolujie).
(3) The experimental method comprises the following steps: the patients were randomly divided into 3 groups, the first group was used for brushing teeth with commercially available antiallergic toothpaste, the second group was used for brushing teeth with 0.5 ‰ toothpaste, and the third group was used for brushing teeth with 1 ‰ toothpaste for 2 times per day, with the toothpaste amount of 2cm for each time, and the tooth brushing time of 5min for each time. And observing the recovery condition and the recovery time of the gum of the patient.
The healing standard is as follows: the bleeding gum disappears.
(4) Results of the experiment
The results are shown in table 2, on the 7 th day of the experiment, the gingival bleeding of patients after using the toothpaste of the invention is obviously improved, while patients after using the commercially available toothpaste have no obvious effect; on the 15 th day of the experiment, the bleeding frequency of the patient after the commercial toothpaste is used is reduced, but the patient is not cured, and the gum bleeding of the patient after the 0.5 per mill toothpaste or the 1 per mill toothpaste is used disappears and is cured. Obviously, the antiallergic effect of the toothpaste prepared by the invention is better than that of the commercial antiallergic toothpaste, and the antiallergic effect of 1 per mill of the toothpaste is better than that of 0.5 per mill of the toothpaste.
The experiments show that the toothpaste can remarkably improve the anti-allergic effect by adding the pulsatilla saponin into the toothpaste, and the anti-allergic effect is enhanced along with the increase of the addition amount of the pulsatilla saponin.
TABLE 2 comparison of antiallergic Effect
Figure BDA0002384402120000041
In summary, the present invention provides an anti-inflammatory and anti-allergic oral care product or medicament comprising pasqueoside B4. The experimental result shows that the pulsatilla saponin B4 is added into the oral care product, so that the inflammation, pain and inflammation of the gum can be treated, the bleeding symptom of the gum can be treated, and the anti-inflammation and anti-allergy effects of the oral care product can be obviously improved in a short time. Therefore, the pulsatilla saponin B4 has a very good application prospect in preparing anti-inflammatory and/or anti-allergic oral care products or medicines as an active ingredient.

Claims (10)

1. An anti-inflammatory and/or anti-allergic oral care product or medicament, characterized in that: the oral care product or the medicine comprises pulsatilla saponin B4.
2. The oral care product or medicament of claim 1, wherein: in the oral care product or the medicine, the weight ratio of the pulsatilla chinensis saponin B4 is more than 0.5 per mill.
3. The oral care product or medicament of claim 1, wherein: in the oral care product or the medicine, the weight ratio of the pulsatilla chinensis saponin B4 is 0.5-1 per mill.
4. An oral care product or medicament according to any one of claims 1 to 3, wherein: the oral care product is a toothpaste or mouthwash.
5. The oral care product or medicament of claim 4, wherein: the toothpaste is prepared from the pulsatilla saponin B4 and other components, wherein the other components comprise an abrasive, a humectant, a foaming agent, an adhesive, a spice, a sweetener, a preservative and water;
preferably, the friction agent is calcium carbonate, the humectant is sorbitol, the foaming agent is sodium lauryl sulfate, the binder is sodium carboxymethylcellulose, the sweetener is saccharin, and the preservative is ethylparaben.
6. The oral care product or medicament of claim 5, wherein: in the rest components, the content of the abrasive is 37.0-41.0 wt.%, preferably 39.0 wt.%; the humectant content is 20.0-24.0 wt.%, preferably 22.0 wt.%; the content of the foaming agent is 1.0-1.5 wt.%, preferably 1.3 wt.%; the content of the adhesive is 1.0-1.2 wt.%, preferably 1.1 wt.%; the perfume content is 0.8-1.2 wt.%, preferably 1.0 wt.%; the content of the sweetening agent is 0.05-0.15 wt.%, preferably 0.10 wt.%; the content of the preservative is less than 0.3 wt.%; the remainder was water.
7. Use of pulsatilla saponin B4 in the preparation of an anti-inflammatory and/or anti-allergic oral care product or medicament.
8. Use according to claim 7, characterized in that: in the oral care product or the medicine, the weight ratio of the pulsatilla chinensis saponin B4 is more than 0.5 per thousand, preferably 0.5 per thousand to 1 per thousand.
9. Use according to claim 7, characterized in that: the oral care product is a toothpaste or mouthwash.
10. Use according to any one of claims 7 to 9, characterized in that: the oral care product or medicament is capable of treating inflammation, pain, redness and/or bleeding of the gums.
CN202010093186.5A 2020-02-14 2020-02-14 Oral care product or medicament for anti-inflammation and/or anti-allergy Pending CN111249289A (en)

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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113318002A (en) * 2021-06-12 2021-08-31 广西馨海药业科技有限公司 Anti-inflammation acne-removing composition and cosmetic
CN114452292A (en) * 2022-01-28 2022-05-10 中国中医科学院中药研究所 Application of pulsatilla saponin B4 in preparation of skin care products
CN114469969A (en) * 2022-01-28 2022-05-13 中国中医科学院中药研究所 Application of pulsatilla saponin B5 in preparation of skin care products
EP4238570A4 (en) * 2022-01-18 2024-06-05 Guangxi Xinhai Pharmaceutical Technology Co., Ltd Hair growth promoting composition, hair growth promoting drug and use

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Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113318002A (en) * 2021-06-12 2021-08-31 广西馨海药业科技有限公司 Anti-inflammation acne-removing composition and cosmetic
CN113318002B (en) * 2021-06-12 2024-01-19 广西馨海药业科技有限公司 Anti-inflammatory acne-removing composition and cosmetic
EP4238570A4 (en) * 2022-01-18 2024-06-05 Guangxi Xinhai Pharmaceutical Technology Co., Ltd Hair growth promoting composition, hair growth promoting drug and use
CN114452292A (en) * 2022-01-28 2022-05-10 中国中医科学院中药研究所 Application of pulsatilla saponin B4 in preparation of skin care products
CN114469969A (en) * 2022-01-28 2022-05-13 中国中医科学院中药研究所 Application of pulsatilla saponin B5 in preparation of skin care products
CN114452292B (en) * 2022-01-28 2022-09-27 中国中医科学院中药研究所 Application of pulsatilla saponin B4 in preparation of skin care products

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Application publication date: 20200609