CN111094313A - 盐酸伊达比星一水合物的晶型 - Google Patents
盐酸伊达比星一水合物的晶型 Download PDFInfo
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- CN111094313A CN111094313A CN201880057475.0A CN201880057475A CN111094313A CN 111094313 A CN111094313 A CN 111094313A CN 201880057475 A CN201880057475 A CN 201880057475A CN 111094313 A CN111094313 A CN 111094313A
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- idarubicin hydrochloride
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- hydrochloride monohydrate
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- idarubicin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/24—Condensed ring systems having three or more rings
- C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
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- Veterinary Medicine (AREA)
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- Animal Behavior & Ethology (AREA)
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- Pharmacology & Pharmacy (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
本发明公开了盐酸伊达比星一水合物的新晶型，新晶型的制备方法，包含该新晶型的药物组合物以及其在预防和/或治疗肿瘤疾病中的医药用途。
Description
PCT国内申请，说明书已公开。
Claims (16)
- PCT国内申请，权利要求书已公开。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2017108644123 | 2017-09-22 | ||
| CN201710864412 | 2017-09-22 | ||
| PCT/CN2018/107008 WO2019057165A1 (zh) | 2017-09-22 | 2018-09-21 | 盐酸伊达比星一水合物的晶型 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN111094313A true CN111094313A (zh) | 2020-05-01 |
| CN111094313B CN111094313B (zh) | 2022-07-05 |
Family
ID=65809536
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201880057475.0A Active CN111094313B (zh) | 2017-09-22 | 2018-09-21 | 盐酸伊达比星一水合物的晶型 |
Country Status (2)
| Country | Link |
|---|---|
| CN (1) | CN111094313B (zh) |
| WO (1) | WO2019057165A1 (zh) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN117417397A (zh) * | 2023-10-17 | 2024-01-19 | 浙江亚瑟医药有限公司 | 一种盐酸伊达比星晶型及其制备方法 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN85103835A (zh) * | 1985-05-13 | 1986-11-12 | 法米塔利·卡洛·埃尔巴有限公司 | 制备4-脱甲氧-道诺红菌素的改进方法 |
| PL195417B1 (pl) * | 2000-10-10 | 2007-09-28 | Inst Farmaceutyczny | Korzystna farmaceutycznie forma krystaliczna hydratu chlorowodorku idarubicyny, sposób jej otrzymywania i zawierające ją środki farmaceutyczne |
| CN103906757A (zh) * | 2011-09-19 | 2014-07-02 | 贺利氏贵金属有限责任两合公司 | 盐酸伊达比星的结晶 |
-
2018
- 2018-09-21 WO PCT/CN2018/107008 patent/WO2019057165A1/zh active Application Filing
- 2018-09-21 CN CN201880057475.0A patent/CN111094313B/zh active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN85103835A (zh) * | 1985-05-13 | 1986-11-12 | 法米塔利·卡洛·埃尔巴有限公司 | 制备4-脱甲氧-道诺红菌素的改进方法 |
| PL195417B1 (pl) * | 2000-10-10 | 2007-09-28 | Inst Farmaceutyczny | Korzystna farmaceutycznie forma krystaliczna hydratu chlorowodorku idarubicyny, sposób jej otrzymywania i zawierające ją środki farmaceutyczne |
| CN103906757A (zh) * | 2011-09-19 | 2014-07-02 | 贺利氏贵金属有限责任两合公司 | 盐酸伊达比星的结晶 |
Non-Patent Citations (1)
| Title |
|---|
| 蒲刚等: "盐酸伊达比星的半合成研究", 《中国抗生素杂志》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN117417397A (zh) * | 2023-10-17 | 2024-01-19 | 浙江亚瑟医药有限公司 | 一种盐酸伊达比星晶型及其制备方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| CN111094313B (zh) | 2022-07-05 |
| WO2019057165A1 (zh) | 2019-03-28 |
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