CN110856737A - 一种治疗湿热痹阻所致痹病的中药组方及其配制方法 - Google Patents
一种治疗湿热痹阻所致痹病的中药组方及其配制方法 Download PDFInfo
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Abstract
本发明涉及附属装置的技术领域，特别是涉及一种治疗湿热痹阻所致痹病的中药组方及其配制方法，其可以减少患者急躁情绪，并且缓解湿热痹阻病症；是由以下质量的中药原料制备而成：苍术200‑300g、黄柏150‑250g、知母100‑120g、生石膏300‑350g、金银花600‑700g、连翘350‑600g、木瓜500‑580g、地龙20‑40g、薏苡仁600‑800g、老鹳草50‑90g、川牛膝250‑300g、威灵仙150‑200g、黄芩300‑350g、栀子200‑240g、鸡血藤60‑150g、马齿笕50‑100g、土茯苓500‑600g、苦竹根40‑60g、甘草100‑150g和泽泻50‑80g。
Description
技术领域
本发明涉及附属装置的技术领域，特别是涉及一种治疗湿热痹阻所致痹病的中药组方及其配制方法。
背景技术
众所周知，湿热，为致病因素，属于六淫风、寒、暑、湿、燥、火（热）中的两邪，亦为中医证侯命，如湿热证，是指湿热蕴结体内，脏腑经络运行受阻，可见全身湿热症状的病理变化。所谓湿，即通常所说的水湿，它有外湿和内湿区分。外湿属于外邪，称为湿邪，多由于气候潮湿或涉水淋浴或居住潮湿，使外来水湿入侵人体引起，其致病具有重浊、粘滞和趋下特征，内湿使一种病理产物，与脏腑功能失调有关。热，也是一种邪气，致病具有炎热升腾等特性，称为火热之邪，热液可以因机体脏腑功能失调产生，称内热，火热之邪侵犯人体或机体脏腑功能失调产生内热时刻导致热证，热证是感受外邪，或人体技能活动亢进，阳盛阴衰的证候。热证的临床表面为发热，口渴喜冷饮，面红目赤，小便短赤，大便燥结，舌红苔黄干，脉数。
湿热，是湿与热同时侵犯人体，或同时存在体内的病理变化，或因夏秋季节天热湿重，湿与热合并入侵人体，或可因湿久留不除而化热，湿热流注关节则谓湿热痹阻。
湿热痹阻是由于湿邪入里化热，或素体阳生，内有藴热，湿热交蒸而致。症见关节红肿热痛，病势较急，局部灼热，得凉则舒，其是现在生活中人们常常会出现的问题，患者容易产生急躁情绪，因此，对治疗湿热痹阻所致的弊病的研究十分必要。
发明内容
为解决上述技术问题，本发明提供一种可以减少患者急躁情绪，并且缓解湿热痹阻病症的治疗湿热痹阻所致痹病的中药组方及其配制方法。
本发明的一种治疗湿热痹阻所致痹病的中药组方，是由以下质量的中药原料制备而成：苍术200-300g、黄柏150-250g、知母100-120g、生石膏300-350g、金银花600-700g、连翘350-600g、木瓜500-580g、地龙20-40g、薏苡仁600-800g、老鹳草50-90g、川牛膝250-300g、威灵仙150-200g、黄芩300-350g、栀子200-240g、鸡血藤60-150g、马齿笕50-100g、土茯苓500-600g、苦竹根40-60g、甘草100-150g和泽泻50-80g。
本发明的一种治疗湿热痹阻所致痹病的中药组方，优选的，是由以下质量的中药原料制备而成：苍术250g、黄柏200g、知母110g、生石膏325g、金银花650g、连翘475g、木瓜540g、地龙30g、薏苡仁700g、老鹳草70g、川牛膝275g、威灵仙175g、黄芩325g、栀子220g、鸡血藤105g、马齿笕75g、土茯苓550g、苦竹根50g、甘草125g和泽泻65g。
本发明的一种治疗湿热痹阻所致痹病的中药组方的配制方法，包括以下步骤：
（1）第一次煎煮：将苍术、黄柏、知母、生石膏、金银花、连翘、木瓜、地龙、薏苡仁、老鹳草、川牛膝、威灵仙、黄芩、栀子、鸡血藤、马齿笕、土茯苓、苦竹根、甘草和泽泻混合加入煎煮容器中，并向煎煮容器中加入水，使水没过药材表面，对药材进行浸泡处理2h，浸泡完成后对煎煮容器进行加热，对药材进行第一次煎煮1.5h，煎煮完成后将第一煎煮药液倒出；
（2）第二次煎煮：继续向煎煮容器内添加水分，使水分没过药材，并对药材进行第二次煎煮2h，煎煮完成后将第二次煎煮药液倒出；
（3）第三次煎煮：继续向煎煮容器内添加水分，使水分没过药材，并对药材进行第三次煎煮1.5h，煎煮完成后将第三次煎煮药液倒出；
（4）离心过滤：将第一次煎煮药液、第二次煎煮药液和第三次煎煮药液混合，并对其进行离心处理，离心处理后对其进行过滤，去除其中残余的杂质；
（5）沉淀处理：对离心后的过滤液进行浓缩，当浓缩至比重为1：1时，向其中加入2倍体积的乙醇，并充分混匀，放置12h，并对其进行过滤；
（6）蒸发浓缩：对留取的上清液进行真空低温蒸发浓缩，去除其中的乙醇，并使药液呈稠膏状；
（7）干燥处理：将稠膏状的药膏降温至-50℃，并在真空下进行干燥处理，使药膏变成药粉；
（8）压制成片：将干燥后的药粉预压成药片；
（9）粉碎造粒：将压制完成后的药片粉碎，制得药物颗粒；
（10）分装：将药物颗粒分装，每袋中药物颗粒质量为2g。
本发明的一种治疗湿热痹阻所致痹病的中药组方及其配制方法，所述步骤（5）中的对离心后的过滤液进行浓缩包括真空浓缩，即在真空度为1.33kPa，40℃下对过滤液进行浓缩。
本发明的一种治疗湿热痹阻所致痹病的中药组方及其配制方法，所述步骤（5）中的进行过滤包括将上清液与沉淀物过滤分离和对沉淀物用少量50%-60%的乙醇洗净并再次进行过滤后与上清液混合。
与现有技术相比本发明的有益效果为：本发明将苍术、黄柏、知母、生石膏、金银花、连翘、木瓜、地龙、薏苡仁、老鹳草、川牛膝、威灵仙、黄芩、栀子、鸡血藤、马齿笕、土茯苓、苦竹根、甘草和泽泻按照一定比例混合在一起，其中苍术具有燥湿健脾的作用；黄柏具有清热燥湿，泻火除蒸的作用；知母具有清热泻火，滋阴润燥的作用；生石膏具有清热泻火和除烦止渴的作用；金银花具有消炎解热的作用；连翘具有清热解毒，散结消肿的作用；地龙具有清热息风，通经活络的作用；薏苡仁具有一定的利水渗透湿、除痹和解毒散结的作用；老鹳草具有清热解毒的作用；川牛膝具有逐瘀通经，通利关节的作用；威灵仙具有祛风除湿和通络止痛的作用；黄芩具有清热燥湿和泻火解毒的作用；栀子具有泻火除烦，清热利湿的作用；鸡血藤具有活血舒筋，养血调经的作用；马齿笕具有杀菌消炎的作用；土茯苓具有良好的解毒除湿利关节作用；苦竹根具有清热除烦的作用；甘草具有清热解毒的功能；泽泻具有利水渗湿，泻热抑菌的作用，其混合在一起得到的组方经过一定的处理后得到的药物颗粒对于治疗湿热痹阻所致的弊病十分有效，其成分在被人体服用后进入人体内部，并由人体吸收至湿热淤积处，缓解患者的症状，并且可以减轻患者的急躁情绪，具有良好的应用前景。
具体实施方式
下面结合实施例，对本发明的具体实施方式作进一步详细描述。以下实施例用于说明本发明，但不用来限制本发明的范围。
实施例1
将苍术250g、黄柏200g、知母110g、生石膏325g、金银花650g、连翘475g、木瓜540g、地龙30g、薏苡仁700g、老鹳草70g、川牛膝275g、威灵仙175g、黄芩325g、栀子220g、鸡血藤105g、马齿笕75g、土茯苓550g、苦竹根50g、甘草125g和泽泻65g混合加入煎煮容器中，并向煎煮容器中加入水，使水没过药材表面，对药材进行浸泡处理2h，浸泡完成后对煎煮容器进行加热，对药材进行第一次煎煮1.5h，煎煮完成后将第一煎煮药液倒出，继续向煎煮容器内添加水分，使水分没过药材，并对药材进行第二次煎煮2h，煎煮完成后将第二次煎煮药液倒出，继续向煎煮容器内添加水分，使水分没过药材，并对药材进行第三次煎煮1.5h，煎煮完成后将第三次煎煮药液倒出；
将第一次煎煮药液、第二次煎煮药液和第三次煎煮药液混合，并对其进行离心处理，离心处理后对其进行过滤，去除其中残余的杂质，对离心后的过滤液在真空度为1.33kPa，40℃下对过滤液进行浓缩，当浓缩至比重为1：1时，向其中加入2倍体积的乙醇，并充分混匀，放置12h，将上清液与沉淀物过滤分离，并对沉淀物用少量50%-60%的乙醇洗净并再次进行过滤后与上清液混合；
对留取的上清液进行真空低温蒸发浓缩，去除其中的乙醇，并使药液呈稠膏状，将稠膏状的药膏降温至-50℃，并在真空下进行干燥处理，使药膏变成药粉，将干燥后的药粉预压成药片，将压制完成后的药片粉碎，制得药物颗粒，滨海将药物颗粒分装，每袋中药物颗粒质量为2g。
实施例2
将苍术200g、黄柏150g、知母100g、生石膏300g、金银花600g、连翘350g、木瓜500g、地龙20g、薏苡仁600g、老鹳草50g、川牛膝250g、威灵仙150g、黄芩300g、栀子200g、鸡血藤60g、马齿笕50g、土茯苓500g、苦竹根40g、甘草100g和泽泻50g混合加入煎煮容器中，并向煎煮容器中加入水，使水没过药材表面，对药材进行浸泡处理2h，浸泡完成后对煎煮容器进行加热，对药材进行第一次煎煮1.5h，煎煮完成后将第一煎煮药液倒出，继续向煎煮容器内添加水分，使水分没过药材，并对药材进行第二次煎煮2h，煎煮完成后将第二次煎煮药液倒出，继续向煎煮容器内添加水分，使水分没过药材，并对药材进行第三次煎煮1.5h，煎煮完成后将第三次煎煮药液倒出；
将第一次煎煮药液、第二次煎煮药液和第三次煎煮药液混合，并对其进行离心处理，离心处理后对其进行过滤，去除其中残余的杂质，对离心后的过滤液在真空度为1.33kPa，40℃下对过滤液进行浓缩，当浓缩至比重为1：1时，向其中加入2倍体积的乙醇，并充分混匀，放置12h，将上清液与沉淀物过滤分离，并对沉淀物用少量50%-60%的乙醇洗净并再次进行过滤后与上清液混合；
对留取的上清液进行真空低温蒸发浓缩，去除其中的乙醇，并使药液呈稠膏状，将稠膏状的药膏降温至-50℃，并在真空下进行干燥处理，使药膏变成药粉，将干燥后的药粉预压成药片，将压制完成后的药片粉碎，制得药物颗粒，滨海将药物颗粒分装，每袋中药物颗粒质量为2g。
实施例3
将苍术300g、黄柏250g、知母120g、生石膏350g、金银花700g、连翘600g、木瓜580g、地龙40g、薏苡仁800g、老鹳草90g、川牛膝300g、威灵仙200g、黄芩350g、栀子240g、鸡血藤150g、马齿笕100g、土茯苓600g、苦竹根60g、甘草150g和泽泻80g混合加入煎煮容器中，并向煎煮容器中加入水，使水没过药材表面，对药材进行浸泡处理2h，浸泡完成后对煎煮容器进行加热，对药材进行第一次煎煮1.5h，煎煮完成后将第一煎煮药液倒出，继续向煎煮容器内添加水分，使水分没过药材，并对药材进行第二次煎煮2h，煎煮完成后将第二次煎煮药液倒出，继续向煎煮容器内添加水分，使水分没过药材，并对药材进行第三次煎煮1.5h，煎煮完成后将第三次煎煮药液倒出；
将第一次煎煮药液、第二次煎煮药液和第三次煎煮药液混合，并对其进行离心处理，离心处理后对其进行过滤，去除其中残余的杂质，对离心后的过滤液在真空度为1.33kPa，40℃下对过滤液进行浓缩，当浓缩至比重为1：1时，向其中加入2倍体积的乙醇，并充分混匀，放置12h，将上清液与沉淀物过滤分离，并对沉淀物用少量50%-60%的乙醇洗净并再次进行过滤后与上清液混合；
对留取的上清液进行真空低温蒸发浓缩，去除其中的乙醇，并使药液呈稠膏状，将稠膏状的药膏降温至-50℃，并在真空下进行干燥处理，使药膏变成药粉，将干燥后的药粉预压成药片，将压制完成后的药片粉碎，制得药物颗粒，滨海将药物颗粒分装，每袋中药物颗粒质量为2g。
本发明将苍术、黄柏、知母、生石膏、金银花、连翘、木瓜、地龙、薏苡仁、老鹳草、川牛膝、威灵仙、黄芩、栀子、鸡血藤、马齿笕、土茯苓、苦竹根、甘草和泽泻按照一定比例混合在一起，其中苍术具有燥湿健脾的作用；黄柏具有清热燥湿，泻火除蒸的作用；知母具有清热泻火，滋阴润燥的作用；生石膏具有清热泻火和除烦止渴的作用；金银花具有消炎解热的作用；连翘具有清热解毒，散结消肿的作用；地龙具有清热息风，通经活络的作用；薏苡仁具有一定的利水渗透湿、除痹和解毒散结的作用；老鹳草具有清热解毒的作用；川牛膝具有逐瘀通经，通利关节的作用；威灵仙具有祛风除湿和通络止痛的作用；黄芩具有清热燥湿和泻火解毒的作用；栀子具有泻火除烦，清热利湿的作用；鸡血藤具有活血舒筋，养血调经的作用；马齿笕具有杀菌消炎的作用；土茯苓具有良好的解毒除湿利关节作用；苦竹根具有清热除烦的作用；甘草具有清热解毒的功能；泽泻具有利水渗湿，泻热抑菌的作用，其混合在一起得到的组方经过一定的处理后得到的药物颗粒对于治疗湿热痹阻所致的弊病十分有效，其成分在被人体服用后进入人体内部，并由人体吸收至湿热淤积处，缓解患者的症状，并且可以减轻患者的急躁情绪，具有良好的应用前景。
以60名由湿热闭阻导致痹病的患者，每20名为1组，分为3组实验组，3组实验组的患者分别服用实施例1至实施例3中的袋装药物颗粒，一天三次，每次以500ml温开水冲泡送服，连续服用7天，其中服用实施例1中的药物颗粒的患者约4-5天时病症均有所好转，并且其停药后无反复现象；服用实施例2中的药物颗粒的患者7天后病情有所好转，但停药后大部分患者均有反复现象；服用实施例3中的药物颗粒的患者约5-7天时病情有所好转，并且其停药后反复现象较少，综上，实施例1中的配方生产出的药物颗粒的疗效较好。
以上所述仅是本发明的优选实施方式，应当指出，对于本技术领域的普通技术人员来说，在不脱离本发明技术原理的前提下，还可以做出若干改进和变型，这些改进和变型也应视为本发明的保护范围。
Claims (5)
1.一种治疗湿热痹阻所致痹病的中药组方，其特征在于，是由以下质量的中药原料制备而成：苍术200-300g、黄柏150-250g、知母100-120g、生石膏300-350g、金银花600-700g、连翘350-600g、木瓜500-580g、地龙20-40g、薏苡仁600-800g、老鹳草50-90g、川牛膝250-300g、威灵仙150-200g、黄芩300-350g、栀子200-240g、鸡血藤60-150g、马齿笕50-100g、土茯苓500-600g、苦竹根40-60g、甘草100-150g和泽泻50-80g。
2.如权利要求1所述的一种治疗湿热痹阻所致痹病的中药组方，其特征在于，优选的，是由以下质量的中药原料制备而成：苍术250g、黄柏200g、知母110g、生石膏325g、金银花650g、连翘475g、木瓜540g、地龙30g、薏苡仁700g、老鹳草70g、川牛膝275g、威灵仙175g、黄芩325g、栀子220g、鸡血藤105g、马齿笕75g、土茯苓550g、苦竹根50g、甘草125g和泽泻65g。
3.本发明的一种治疗湿热痹阻所致痹病的中药组方的配制方法，其特征在于，包括以下步骤：
（1）第一次煎煮：将苍术、黄柏、知母、生石膏、金银花、连翘、木瓜、地龙、薏苡仁、老鹳草、川牛膝、威灵仙、黄芩、栀子、鸡血藤、马齿笕、土茯苓、苦竹根、甘草和泽泻混合加入煎煮容器中，并向煎煮容器中加入水，使水没过药材表面，对药材进行浸泡处理2h，浸泡完成后对煎煮容器进行加热，对药材进行第一次煎煮1.5h，煎煮完成后将第一煎煮药液倒出；
（2）第二次煎煮：继续向煎煮容器内添加水分，使水分没过药材，并对药材进行第二次煎煮2h，煎煮完成后将第二次煎煮药液倒出；
（3）第三次煎煮：继续向煎煮容器内添加水分，使水分没过药材，并对药材进行第三次煎煮1.5h，煎煮完成后将第三次煎煮药液倒出；
（4）离心过滤：将第一次煎煮药液、第二次煎煮药液和第三次煎煮药液混合，并对其进行离心处理，离心处理后对其进行过滤，去除其中残余的杂质；
（5）沉淀处理：对离心后的过滤液进行浓缩，当浓缩至比重为1：1时，向其中加入2倍体积的乙醇，并充分混匀，放置12h，并对其进行过滤；
（6）蒸发浓缩：对留取的上清液进行真空低温蒸发浓缩，去除其中的乙醇，并使药液呈稠膏状；
（7）干燥处理：将稠膏状的药膏降温至-50℃，并在真空下进行干燥处理，使药膏变成药粉；
（8）压制成片：将干燥后的药粉预压成药片；
（9）粉碎造粒：将压制完成后的药片粉碎，制得药物颗粒；
（10）分装：将药物颗粒分装，每袋中药物颗粒质量为2g。
4.如权利要求3所述的一种治疗湿热痹阻所致痹病的中药组方的配制方法，其特征在于，所述步骤（5）中的对离心后的过滤液进行浓缩包括真空浓缩，即在真空度为1.33kPa，40℃下对过滤液进行浓缩。
5.如权利要求3所述的一种治疗湿热痹阻所致痹病的中药组方的配制方法，其特征在于，还包括所述步骤（5）中的进行过滤包括将上清液与沉淀物过滤分离和对沉淀物用少量50%-60%的乙醇洗净并再次进行过滤后与上清液混合。
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