CN110743042A - Antibacterial stoma leakage-proof paste and preparation method thereof - Google Patents
Antibacterial stoma leakage-proof paste and preparation method thereof Download PDFInfo
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- A61L28/00—Materials for colostomy devices
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- A—HUMAN NECESSITIES
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L28/00—Materials for colostomy devices
- A61L28/0007—Materials for colostomy devices containing macromolecular materials
- A61L28/0011—Materials for colostomy devices containing macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L28/00—Materials for colostomy devices
- A61L28/0007—Materials for colostomy devices containing macromolecular materials
- A61L28/0019—Polysaccharides
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- A—HUMAN NECESSITIES
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L28/00—Materials for colostomy devices
- A61L28/0007—Materials for colostomy devices containing macromolecular materials
- A61L28/0023—Polypeptides; Proteins; Degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L28/00—Materials for colostomy devices
- A61L28/0034—Use of materials characterised by their function or physical properties
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61L28/00—Materials for colostomy devices
- A61L28/0034—Use of materials characterised by their function or physical properties
- A61L28/0038—Medicaments; Biocides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/04—Macromolecular materials
- A61L31/042—Polysaccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/04—Macromolecular materials
- A61L31/043—Proteins; Polypeptides; Degradation products thereof
- A61L31/045—Gelatin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/04—Macromolecular materials
- A61L31/048—Macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L31/16—Biologically active materials, e.g. therapeutic substances
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- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
- A61L2300/106—Halogens or compounds thereof, e.g. iodine, chlorite
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
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Abstract
The application discloses an antibacterial stoma leakage-proof paste, which comprises the following raw materials in parts by weight: 8-28 parts of ethanol, 2-10 parts of isopropanol, 30-50 parts of polyvinylpyrrolidone, 1-3 parts of povidone iodine, 20-28 parts of croscarmellose sodium and 5-15 parts of gelatin. The invention also provides a preparation method of the antibacterial stoma leakage-proof paste. The leakproof paste prepared by the preparation method has excellent antibacterial property and is not easy to fall off.
Description
Technical Field
The invention relates to the technical field of leakage-proof paste, in particular to antibacterial stoma leakage-proof paste and a preparation method thereof.
Background
Intestinal cancer is a common malignant tumor of the digestive tract, wherein most patients need to do ileum or colostomy, the total number of patients with intestinal stoma is over 100 ten thousand at present in China, about 10 ten thousand patients are newly added every year, and the trend is increased, the intestinal stoma is an important means for saving and continuing the life of the patients and improving the life quality of the patients, but because the intestinal stoma is not controlled by sphincter muscle, directly stimulates stool and is frequently changed, the skin around the stoma is very easy to turn red and pruritus, even ulcer, infection and the like.
The leakage-proof paste is paste, most of leakage-proof paste products existing in the current market are free of alcohol, the main components of the leakage-proof paste are liquid rubber and high-molecular water-absorbing materials, the most main liquid rubber comprises polyisobutylene, polyisoprene and the like, and the leakage-proof paste can seal and fill the concave part of the skin around the stoma, so that the ostomy bag can be firmly adhered, the service time of the ostomy bag can be effectively prolonged, the skin tearing stimulation caused by frequent replacement of the ostomy bag can be prevented, the leakage phenomenon caused by long-term soaking of excrement in the inner edge of the ostomy bag can be effectively prevented, and the skin stimulation caused by excrement can be reduced.
Chinese patent application document 'an alcohol-free leakage-proof paste for ostomy care and a preparation method thereof (application publication No. CN 108744066A)' discloses an alcohol-free leakage-proof paste for ostomy care and a preparation method thereof, and the alcohol-free leakage-proof paste comprises the following components in parts by weight: liquid polyisoprene rubber: 40-55 parts, sodium carboxymethyl cellulose: 20-40 parts of karaya gum: 5-10 parts of white carbon black: 2-6 parts of inorganic clay: 2-6 parts, glycerol: 2-4 parts, 1, 2-propylene glycol: 1-4 parts, 1, 3-butanediol: 1-4 parts, mineral oil: 1-4 parts. The leakage-proof paste for ostomy care does not contain alcohol and has corrosion resistance, but is difficult to extrude when in use, has low plasticity, and obviously difficult to remove residues after use.
Chinese patent application document 'a corrosion-resistant stoma leakage-proof paste and a preparation method thereof (application publication No. CN 108992713A)' discloses a corrosion-resistant stoma leakage-proof paste and a preparation method thereof, which comprises the following components in parts by weight: liquid polyisoprene rubber: 40-60 parts of karaya gum: 10-35 parts of inorganic clay: 2-6 parts, glycerol: 8-20 parts of 1, 2-propylene glycol: 0.5-2 parts, mineral oil: 0.5-4 parts of sodium polyacrylate: 2-10 parts of aluminum hydroxide: 0.1-1 part, citric acid: 0.2-1 part. The leakage-proof paste for ostomy care does not contain alcohol and has corrosion resistance, but is difficult to extrude when in use, has low plasticity, and obviously difficult to remove residues after use.
Disclosure of Invention
The invention aims to overcome the defects of the prior art and provide an ostomy leakage-proof paste which can improve antibacterial property and reduce paste residue.
The technical scheme adopted by the invention is as follows:
an antibacterial stoma leakage-proof paste comprises the following raw materials in parts by weight: 8-28 parts of ethanol, 2-10 parts of isopropanol, 30-50 parts of polyvinylpyrrolidone, 1-3 parts of povidone iodine, 20-28 parts of croscarmellose sodium and 5-15 parts of gelatin.
Further, 10-26 parts of ethanol, 4-8 parts of isopropanol, 35-45 parts of polyvinylpyrrolidone, 1.5-2.5 parts of povidone iodine, 22-26 parts of cross-linked sodium carboxymethyl cellulose and 8-12 parts of gelatin.
Further, 18 parts of ethanol, 6 parts of isopropanol, 40 parts of polyvinylpyrrolidone, 2 parts of povidone iodine, 24 parts of croscarmellose sodium and 10 parts of gelatin.
Further, the weight ratio of the ethanol to the povidone iodine is 8-28: 1-3.
Further, the weight ratio of the ethanol to the povidone iodine is 18: 2.
the invention also discloses a preparation method of the antibacterial stoma leakage-proof paste, which comprises the following steps: uniformly mixing ethanol, isopropanol, polyvinylpyrrolidone, povidone iodine, croscarmellose sodium and gelatin according to a ratio, adding into a high-speed mixing stirrer for stirring, pressing the mixed paste body to an automatic canning hopper through an extrusion disc, and completing automatic canning.
Further, the rotating speed of the high-speed mixing stirrer is 650-850r/min
The invention has the beneficial effects that: .
The antibacterial stoma leakage-proof paste takes ethanol, isopropanol, polyvinylpyrrolidone, povidone iodine, crosslinked sodium carboxymethyl cellulose and gelatin as raw materials, wherein the povidone iodine is a broad-spectrum strong sterilization disinfectant, has strong killing effect on viruses, bacteria, fungi and mould spores, and has small irritation to skin, low toxicity and lasting effect. Povidone iodine is a loose compound formed by combining element iodine and a polymer carrier, povidone plays a role in carrier and dissolution aid, and the oxidation effect of free iodine plays a role in killing microorganisms. Povidone iodine is easily dissolved in water or ethanol, and after being dissolved in the ethanol, iodine is gradually released in the solvent to play a slow release role so as to keep the bactericidal power for a long time. A certain amount of ethanol and povidone iodine are added into the formula, so that the povidone iodine can be well dissolved in the ethanol, and a continuous sterilization effect is achieved, and the ointment has antibacterial performance. The polyvinylpyrrolidone has excellent physiological inertia, does not participate in human metabolism, has excellent biocompatibility and does not cause any stimulation to skin, mucous membrane, eyes and the like. The polyvinyl pyrrolidone is a polymer which is very easy to dissolve in alcohol, and has good dispersibility, film forming property, caking property and shaping capability after being dissolved. The polyvinyl pyrrolidone is introduced into the formula, so that the paste can quickly form a layer of film-shaped materials which are connected with each other and have viscosity after being smeared, the film-shaped materials are well fused with the rubber plate, the film-shaped materials can be peeled off along with the rubber plate after the rubber plate is peeled off, and obvious residual paste cannot be left on the skin. The sterilization effect of the free iodine in the povidone iodine is utilized, the output of the continuous free iodine is realized under the slow release effect of the povidone iodine under the sustained release effect of the povidone carrier, the sterilization durability is ensured, the sterilization performance is effectively improved, in addition, the paste is not easy to peel off after being smeared due to the strong film forming property and the strong caking property of the polyvinylpyrrolidone, and the dispersion effect of the polyvinylpyrrolidone ensures that the antibacterial stoma leakage-proof paste can continuously obtain better output of the free iodine when being used, the durable antibacterial effect is ensured, and the problems of quick volatilization and low sterilization duration of the single ethanol used as the antibacterial agent are solved.
Additional features and advantages of the invention will be set forth in the detailed description which follows.
Detailed Description
The technical solutions of the present invention are explained and illustrated below with reference to the following embodiments of the present invention, but the following embodiments are only preferred embodiments of the present invention, and not all embodiments. Based on the embodiments in the implementation, other embodiments obtained by those skilled in the art without any creative effort belong to the protection scope of the present invention.
Example 1:
the antibacterial ostomy leakage-proof paste provided by the embodiment of the invention comprises the following raw materials in parts by weight: 18 parts of ethanol, 6 parts of isopropanol, 40 parts of polyvinylpyrrolidone, 2 parts of povidone iodine, 24 parts of crosslinked carboxymethyl cellulose sodium and 10 parts of gelatin.
Example 2:
the antibacterial ostomy leakage-proof paste provided by the embodiment of the invention comprises the following raw materials in parts by weight: 8 parts of ethanol, 10 parts of isopropanol, 30 parts of polyvinylpyrrolidone, 3 parts of povidone iodine, 20 parts of crosslinked carboxymethyl cellulose sodium and 15 parts of gelatin.
Example 3:
the antibacterial ostomy leakage-proof paste provided by the embodiment of the invention comprises the following raw materials in parts by weight: 28 parts of ethanol, 2 parts of isopropanol, 50 parts of polyvinylpyrrolidone, 1 part of povidone iodine, 28 parts of crosslinked sodium carboxymethyl cellulose and 5 parts of gelatin.
Example 4:
the antibacterial ostomy leakage-proof paste provided by the embodiment of the invention comprises the following raw materials in parts by weight: 10 parts of ethanol, 8 parts of isopropanol, 35 parts of polyvinylpyrrolidone, 2.5 parts of povidone iodine, 22 parts of croscarmellose sodium and 12 parts of gelatin.
Example 5
The antibacterial ostomy leakage-proof paste provided by the embodiment of the invention comprises the following raw materials in parts by weight: 26 parts of ethanol, 4 parts of isopropanol, 45 parts of polyvinylpyrrolidone, 1.5 parts of povidone iodine, 26 parts of croscarmellose sodium and 8 parts of gelatin.
Comparative example 1
The preparation process is basically the same as that of example 1, except that the raw materials for preparing the antibacterial stoma sealing paste lack ethanol and povidone iodine.
Comparative example 2
The preparation process was substantially the same as that of example 1, except that the raw materials for preparing the antibacterial stoma sealant were deficient in ethanol.
Comparative example 3
The preparation process is basically the same as that of example 1, except that povidone-iodine is absent from the raw materials for preparing the antibacterial stoma leakproof paste.
Comparative example 4
The preparation process is basically the same as that of the example 1, except that 6 parts of ethanol and 5 parts of povidone iodine are used as raw materials for preparing the antibacterial stoma leakage-proof paste.
Comparative example 5
The preparation process is basically the same as that of the example 1, except that 29 parts of ethanol and 0.5 part of povidone iodine are used as raw materials for preparing the antibacterial stoma leakage-proof paste.
Comparative example 6
The preparation method adopts the process of the Chinese patent application document 'an alcohol-free leakproof paste for ostomy care and a preparation method thereof (application publication No. CN 108744066A)' examples 1-3.
Comparative example 7
The corrosion-resistant stoma leakage-proof paste and the preparation method thereof (application publication number: CN108992713A)) are adopted in Chinese patent application documents, and the paste is prepared by the process of the example 1-3.
The pastes obtained in examples 1 to 5 and comparative examples 1 to 7 were examined, respectively: taking a certain amount of (5G) paste by using a scraper, uniformly coating the paste on a stoma rubber disc with the diameter of 5cm, weighing the rubber disc and the paste to obtain M1 by total mass, then adhering the rubber disc and the paste on a PE (polyethylene) plate, removing the stoma rubber disc after 24 hours, weighing the rubber disc and the paste to obtain M2 by mass, wherein the paste residual rate is M1-M2/5/100%;
1. the above test is repeated three times, and the average value is taken to be recorded as the paste residual rate of the paste.
2. Carrying out antibacterial performance detection on the paste according to a GB/T20944.2-2007 antibacterial performance evaluation-absorption method;
3. and (3) evaluating the antibacterial effect, wherein when the antibacterial value is more than or equal to 1 or the antibacterial rate is more than or equal to 90%, the sample has the antibacterial effect. When the bacteriostasis value is more than or equal to 2 or the bacteriostasis rate is more than or equal to 99 percent, the sample has good antibacterial effect.
The result of the detection
In examples 1-5, due to the addition of a certain amount of the antibacterial agent povidone iodine and a certain amount of ethanol, the antibacterial rate of the ointment is more than 90% as shown by antibacterial test results, and the standard of antibacterial effect is reached; in the comparative example 1, no ethanol or povidone iodine exists, so that the antibacterial rate is low; in the comparative example 2, the dissolution of the ethanol and the povidone iodine is poor, and the antibacterial rate is not high; compared with the prior art, no povidone iodine is added in the comparative example 3, the sterilization characteristic of the ethanol can be shown, and the antibacterial rate is low; the antibacterial rate of comparative examples 4 and 5 is also not high because the ratio of ethanol to povidone-iodine is not appropriate; the antibacterial rate is low because no antibacterial material is added in comparative example 6 and comparative example 7.
In examples 1 to 5 and comparative examples 1 to 5, a certain amount of polyvinylpyrrolidone was present, so that the paste residue rate was low.
It produces a major differential causal analysis:
the povidone iodine is a broad-spectrum strong sterilization disinfectant, has strong killing effect on viruses, bacteria, fungi and mould spores, and has small irritation to skin, low toxicity and lasting effect. Povidone iodine is a loose compound formed by combining element iodine and a polymer carrier, povidone plays a role in carrier and dissolution aid, and the oxidation effect of free iodine plays a role in killing microorganisms. Povidone iodine is easily dissolved in water or ethanol, and after being dissolved in the ethanol, iodine is gradually released in the solvent to play a slow release role so as to keep the bactericidal power for a long time. A certain amount of ethanol and povidone iodine are added into the formula, so that the povidone iodine can be well dissolved in the ethanol, and a continuous sterilization effect is achieved, and the ointment has antibacterial performance.
The polyvinylpyrrolidone has excellent physiological inertia, does not participate in human metabolism, has excellent biocompatibility and does not cause any stimulation to skin, mucous membrane, eyes and the like. The polyvinyl pyrrolidone is a polymer which is very easy to dissolve in alcohol, and has good dispersibility, film forming property, caking property and shaping capability after being dissolved. The polyvinyl pyrrolidone is introduced into the formula, so that the paste can quickly form a layer of film-shaped materials which are connected with each other and have viscosity after being smeared, the film-shaped materials are well fused with the rubber plate, the film-shaped materials can be peeled off along with the rubber plate after the rubber plate is peeled off, and obvious residual paste cannot be left on the skin.
The above description is only a preferred embodiment of the present invention, and not intended to limit the scope of the present invention, and all changes that can be made by applying the equivalent structure of the present invention in the specification and directly or indirectly applied to other related technical fields are also included in the scope of the present invention.
Claims (7)
1. The antibacterial stoma leakage-proof paste is characterized by comprising the following raw materials in parts by weight: 8-28 parts of ethanol, 2-10 parts of isopropanol, 30-50 parts of polyvinylpyrrolidone, 1-3 parts of povidone iodine, 20-28 parts of croscarmellose sodium and 5-15 parts of gelatin.
2. The antibacterial ostomy leakproof paste of claim 1, wherein the antibacterial ostomy leakproof paste comprises 10-26 parts of ethanol, 4-8 parts of isopropanol, 35-45 parts of polyvinylpyrrolidone, 1.5-2.5 parts of povidone iodine, 22-26 parts of croscarmellose sodium and 8-12 parts of gelatin.
3. The antibacterial ostomy leakproof paste according to claim 1, wherein the antibacterial ostomy leakproof paste comprises 18 parts of ethanol, 6 parts of isopropanol, 40 parts of polyvinylpyrrolidone, 2 parts of povidone-iodine, 24 parts of croscarmellose sodium and 10 parts of gelatin.
4. The antibacterial ostomy leakproof paste of claim 1, wherein the weight ratio of the ethanol to the povidone-iodine is 8-28: 1-3.
5. The antibacterial ostomy leakproof paste of claim 1, wherein the weight ratio of the ethanol to the povidone-iodine is 18: 2.
6. the method for preparing the antibacterial stoma leakage preventive paste according to any one of claims 1 to 5, comprising the steps of: uniformly mixing ethanol, isopropanol, polyvinylpyrrolidone, povidone iodine, croscarmellose sodium and gelatin according to a ratio, adding into a high-speed mixing stirrer for stirring, pressing the mixed paste body to an automatic canning hopper through an extrusion disc, and completing automatic canning.
7. The method for preparing the antibacterial stoma leakproof paste as claimed in claim 6, wherein the rotation speed of the high-speed mixing stirrer is 650- & 850 r/min.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201911006061.8A CN110743042A (en) | 2019-10-22 | 2019-10-22 | Antibacterial stoma leakage-proof paste and preparation method thereof |
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| CN201911006061.8A CN110743042A (en) | 2019-10-22 | 2019-10-22 | Antibacterial stoma leakage-proof paste and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112716888A (en) * | 2021-01-21 | 2021-04-30 | 巍太医疗科技(常州)有限公司 | Anti-corrosion stoma leakage-proof paste and preparation method thereof |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1299293A (en) * | 1998-04-30 | 2001-06-13 | 科乐医药有限公司 | Adhesive applicator with polymerization agent and/or bioactive material |
| CN101130105A (en) * | 2007-09-13 | 2008-02-27 | 郑州大学 | Wound dressing of povidone iodine hydrogel and radiation preparation method of the same |
| CN103429199A (en) * | 2010-12-20 | 2013-12-04 | 欧麦德公司 | Ostomy device |
| CN104080488A (en) * | 2011-09-02 | 2014-10-01 | 特里奥卫生保健有限公司 | Skin contact material |
| CN105209084A (en) * | 2013-03-13 | 2015-12-30 | 艾利丹尼森公司 | Improving adhesive properties |
| CN106039391A (en) * | 2016-06-21 | 2016-10-26 | 林春梅 | Anti-bacterial high-viscosity medical glue and preparation method thereof |
| WO2017075320A1 (en) * | 2015-10-31 | 2017-05-04 | Dermalink Technologies, Inc. | Skin adhesives, antimicrobial compositions, articles, and methods for the use thereof |
-
2019
- 2019-10-22 CN CN201911006061.8A patent/CN110743042A/en active Pending
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1299293A (en) * | 1998-04-30 | 2001-06-13 | 科乐医药有限公司 | Adhesive applicator with polymerization agent and/or bioactive material |
| CN101130105A (en) * | 2007-09-13 | 2008-02-27 | 郑州大学 | Wound dressing of povidone iodine hydrogel and radiation preparation method of the same |
| CN103429199A (en) * | 2010-12-20 | 2013-12-04 | 欧麦德公司 | Ostomy device |
| CN104080488A (en) * | 2011-09-02 | 2014-10-01 | 特里奥卫生保健有限公司 | Skin contact material |
| CN105209084A (en) * | 2013-03-13 | 2015-12-30 | 艾利丹尼森公司 | Improving adhesive properties |
| WO2017075320A1 (en) * | 2015-10-31 | 2017-05-04 | Dermalink Technologies, Inc. | Skin adhesives, antimicrobial compositions, articles, and methods for the use thereof |
| CN106039391A (en) * | 2016-06-21 | 2016-10-26 | 林春梅 | Anti-bacterial high-viscosity medical glue and preparation method thereof |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112716888A (en) * | 2021-01-21 | 2021-04-30 | 巍太医疗科技(常州)有限公司 | Anti-corrosion stoma leakage-proof paste and preparation method thereof |
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