CN110559175A

CN110559175A - conjunctival sac disinfection solution and using method and device thereof

Info

Publication number: CN110559175A
Application number: CN201910794268.XA
Authority: CN
Inventors: 陈文龙; 周毓; 王梅
Original assignee: Individual
Current assignee: Individual
Priority date: 2019-08-27
Filing date: 2019-08-27
Publication date: 2019-12-13

Abstract

The invention discloses a conjunctival sac disinfection solution and a using method and a device thereof. When the conjunctival sac disinfection solution is used, the conjunctival sac disinfection solution is directly filled into a conjunctival sac washing and disinfecting device, a tour nurse directly opens a sterile table, and an assistant or a main knife carries out washing operation in a sterile environment. The conjunctival sac disinfection solution is prepared by strictly performing aseptic operation under the environment meeting the requirements, so that the conjunctival sac disinfection solution becomes an aseptic product which can be directly washed by an assistant or a main knife under the aseptic environment, the infection risk caused by repeatedly sucking a skin plug is reduced, the secondary pollution in the self-preparation process is avoided, one person can use the conjunctival sac disinfection solution one by one, the waste of human resources and materials generated in the preparation process of the existing disinfection solution is saved, and the aseptic operation principle is obeyed.

Description

Conjunctival sac disinfection solution and using method and device thereof

Technical Field

The invention belongs to the technical field of ophthalmic surgery, and relates to a conjunctival sac disinfection solution and a using method and a device thereof.

Background

Ophthalmic procedures such as cataract surgery, corneal transplantation surgery, vitreoretinal surgery, trabeculectomy for glaucoma, and the like typically require the application of physiological irrigation fluids to protect and maintain the physiological integrity of the intraocular tissue. Solutions for ophthalmic surgical irrigation include gentamicin formulations, lactated ringers solutions, aqueous electrolytes, buffers for PH adjustment, aqueous glutathione solutions, aqueous dextrose solutions, and the like, but have potential factors that are detrimental to corneal and endothelial action.

Most of the washing liquid used for the ophthalmic surgery at present is povidone iodine solution, the povidone iodine solution in the prior art needs to be prepared and sucked, but repeated suction of a skin plug in the actual operation process increases infection risks, secondary pollution is caused by factors such as preparation environment, operators and operation modes in the preparation process of the existing conjunctival sac washing liquid, and the washing is carried out after the sterile environment is established, the sterile operation principle is seriously violated, and the waste of human resources and materials generated in the preparation process of the existing solution is unpredictable. Therefore, there is a need to develop a conjunctival sac disinfection solution which can be irrigated in an aseptic environment without repeated aspiration.

Disclosure of Invention

The technical problem to be solved by the invention is to overcome the defects and provide the conjunctival sac disinfection solution and the using method and the device thereof, the conjunctival sac disinfection solution is combined with the conjunctival sac flushing and disinfecting device, one person can use the conjunctival sac disinfection solution one by one, suction is not needed to be configured, the infection risk caused by repeated suction of the skin plug is reduced, the conjunctival sac can be flushed after a sterile environment is established, and the sterile operation principle is met.

In order to solve the technical problems, the technical scheme of the invention is as follows:

A conjunctival sac disinfection solution comprises povidone iodine, auxiliary materials and purified water, wherein the auxiliary materials comprise sodium iminodisuccinate, potassium iodate, potassium iodide, sodium hydroxide, sodium chloride, potassium chloride and calcium chloride.

Preferably, the conjunctival sac disinfection solution comprises the following raw materials in percentage by weight: povidone iodine 0.14-0.96%, iminodisuccinic acid sodium 0.025-0.125%, potassium iodate 0.12-0.96%, potassium iodide 0.023-0.23%, sodium hydroxide 0.015-0.24%, sodium chloride 0.034-0.12%, potassium chloride 0.0034-0.086%, calcium chloride 0.00132-0.012%, and purified water 97.3-99.6%.

The invention also aims to provide a conjunctival sac washing and disinfecting device, which comprises an outer barrel, a liquid outlet pipe and a ball head, wherein the inner barrel is arranged in the outer barrel, the central axes of the inner barrel and the outer barrel are on the same vertical line, a first valve block which is horizontally distributed is arranged between the inner wall of the outer barrel and the outer wall of the inner barrel, a pressure rod which is vertically distributed is arranged on the upper end surface of the first valve block, the pressure rod is connected to the top end of the outer barrel in a sliding manner, the top end of the pressure rod is arranged on the lower end surface of a pressure plate, the bottom end of the outer barrel is connected with the liquid outlet pipe in a threaded manner, the bottom end of the liquid outlet pipe is integrally connected with the ball head, a first liquid hole and a second liquid hole are arranged on the ball head, a vertical pipe which is vertically distributed is arranged in the ball head, the top end of the vertical pipe is arranged at the bottom end, and the top end of the vertical rod penetrates through the outer cylinder and extends into the sleeve, and the middle section of the vertical rod is rotatably connected with the top end of the outer cylinder.

Preferably, the outer edge and the inner edge of the first valve block are respectively of a circular structure and a square structure, two side faces of the first valve block are respectively attached to the outer cylinder and the inner cylinder, and the top end of the inner cylinder with the square structure in section is in sealing connection with the outer cylinder.

Preferably, the first liquid hole and the second liquid hole are respectively located on the side and the bottom end of the bulb, the first liquid hole is communicated with the interior of the bulb, the second liquid hole is communicated with the vertical pipe, and the bottom end of the vertical pipe is connected with the inner wall of the bulb in a nested mode.

Preferably, the bottom end surface of the vertical rod is provided with a thread layer, the thread layer is in threaded connection with the vertical cylinder, and the vertical cylinder is fixedly connected with the second valve block with a square cross section.

Preferably, the sleeve is vertically and fixedly installed at the center of the pressing plate, the inner wall of the sleeve is in threaded connection with the twist rod, and the twist rod is integrally connected to the vertical rod.

The invention also provides a using method of the conjunctival sac disinfection solution, the conjunctival sac disinfection solution is filled into a conjunctival sac washing and disinfecting device, a tour nurse directly opens a sterile table, and an assistant or a main knife carries out washing operation under a sterile environment, so that one person can use the conjunctival sac disinfection solution one by one, suction is not required to be configured, the infection risk caused by repeatedly sucking a skin plug is reduced, and the sterile operation principle is met.

Compared with the prior art, the invention has the beneficial effects that:

(1) The conjunctival sac disinfection solution takes povidone iodine as a main medicament, and is prepared by adding auxiliary materials of iminodisuccinic acid sodium, potassium iodate, potassium iodide, sodium hydroxide, sodium chloride, potassium chloride and calcium chloride, so that the sterilization solution has a killing effect on various bacteria, spores, viruses, fungi and the like; the preparation of the solution is carried out by strictly executing aseptic operation under the environment meeting the requirements, so that the solution becomes an aseptic product which can be directly washed by an assistant or a main knife under the aseptic environment, the infection risk caused by repeatedly sucking the skin plug is reduced, and the secondary pollution in the self-preparation process is avoided; meanwhile, the proportion of discomfort of the ocular surface of a patient after being disinfected by the disinfection solution is obviously reduced before an operation, the comfort effect of clinical application of the conjunctival sac disinfection solution is obviously better than that of the existing povidone-iodine solution, and the stability of the conjunctival sac disinfection solution is better than that of the existing povidone-iodine solution.

(2) The conjunctival sac washing and disinfecting device is provided with the first valve block and the second valve block which are matched for use, so that liquid medicine can be conveniently sprayed and waste liquid can be absorbed at the bulb through the up-and-down movement of the first valve block and the second valve block; design montant and relevant transmission structure, be convenient for through reciprocating of clamp plate drive two valve blocks synchronous incongruous removal, realized washing of clean liquid medicine and dirty liquid medicine's real-time recovery, ensure that the conjunctival sac can be disinfected by high efficiency, make the sensation of disease more comfortable, reduced medical staff's work load simultaneously, it is more convenient to use.

(3) When the conjunctival sac disinfection solution is used, the conjunctival sac disinfection solution is put into a conjunctival sac flushing and disinfecting device, suction is not needed, disinfection and flushing can be directly performed on an operating table, one person can use the conjunctival sac disinfection solution one by one, manpower resources and material waste generated in the existing disinfection solution preparation process are saved, the aseptic operation principle is followed, and the hospital feeling is met.

Drawings

FIG. 1 is a schematic structural view of a front section of a conjunctival sac irrigation and disinfection device of the invention;

FIG. 2 is a schematic view of the forward view structure of the conjunctival sac irrigation and disinfection device of the invention;

FIG. 3 is a schematic structural view of the conjunctival sac irrigation and disinfection device in a bottom view in section;

Fig. 4 is a schematic structural view of the front section of the sleeve of the conjunctival sac irrigation and disinfection device.

In the figure: 1. an outer cylinder; 2. an inner barrel; 3. a first valve block; 4. a pressure lever; 5. pressing a plate; 6. a liquid outlet pipe; 7. a ball head; 8. a first liquid hole; 9. a second liquid hole; 10. a vertical tube; 11. a second valve block; 12. a vertical cylinder; 13. a vertical rod; 14. a threaded layer; 15. a twisted rod; 16. a sleeve.

Detailed Description

The principles and features of this patent are described below in conjunction with the following drawings, which are provided by way of example to illustrate the patent and not to limit the scope of the patent.

Example 1

a conjunctival sac disinfection solution comprises the following raw materials in percentage by weight: povidone iodine 0.14%, iminodisuccinic acid sodium 0.025%, potassium iodate 0.12%, potassium iodide 0.023%, sodium hydroxide 0.015%, sodium chloride 0.034%, potassium chloride 0.031%, calcium chloride 0.012%, and purified water 99.6%.

Example 2

A conjunctival sac disinfection solution comprises the following raw materials in percentage by weight: povidone iodine 0.96%, iminodisuccinic acid sodium 0.125%, potassium iodate 0.96%, potassium iodide 0.23%, sodium hydroxide 0.24%, sodium chloride 0.09768%, potassium chloride 0.086%, calcium chloride 0.00132%, and purified water 97.3%.

Example 3

A conjunctival sac disinfection solution comprises the following raw materials in percentage by weight: povidone iodine 0.56%, iminodisuccinic acid sodium 0.085%, potassium iodate 0.56%, potassium iodide 0.13%, sodium hydroxide 0.14%, sodium chloride 0.12%, potassium chloride 0.0034%, calcium chloride 0.0016%, and purified water 98.4%.

Example 4

As shown in fig. 1-4, a conjunctival sac washing and disinfecting device comprises an outer barrel 1, an inner barrel 2, a first valve block 3, a pressure rod 4, a pressure plate 5, a liquid outlet pipe 6, a ball head 7, a first liquid hole 8, a second liquid hole 9, a vertical pipe 10, a second valve block 11, a vertical pipe 12, a vertical rod 13, a threaded layer 14, a twist rod 15 and a sleeve 16, wherein the inner barrel 2 is arranged inside the outer barrel 1, the central axes of the inner barrel and the outer barrel are on the same vertical line, the first valve block 3 is horizontally distributed between the inner wall of the outer barrel 1 and the outer wall of the inner barrel 2, the pressure rod 4 is vertically distributed on the upper end surface of the first valve block 3, the pressure rod 4 is connected to the top end of the outer barrel 1 in a sliding manner, the top end of the pressure rod 4 is arranged on the lower end surface of the pressure plate 5, the liquid outlet pipe 6 is connected to the bottom end of the outer barrel 1 in a threaded manner, the ball, and the internally mounted of bulb 7 has vertical distribution's standpipe 10 to the top of standpipe 10 is installed in inner tube 2 bottom, and the inside of inner tube 2 is provided with horizontal distribution's second valve block 11, and the up end of second valve block 11 is connected through the bottom of a vertical section of thick bamboo 12 with montant 13, and the top of montant 13 is passed urceolus 1 and is extended to inside the sleeve 16, and the middle section of montant 13 and the top of urceolus 1 are the rotation connection.

The outward flange and the inward flange of first valve piece 3 are circular and square structure respectively, and both sides face is laminated with urceolus 1 and inner tube 2 respectively mutually, and 2 tops of inner tube and urceolus 1 that the cross-section is square structure are sealing connection, use the finger to press down clamp plate 5, clamp plate 5 drives first valve piece 3 through depression bar 4 in fig. 1 and moves down in step, consequently, the antiseptic solution between urceolus 1 and the inner tube 2 just can enter into inside bulb 7 in fig. 2 via drain pipe 6, the antiseptic solution just can flow out from the first liquid hole 8 department with the inside direct intercommunication of bulb 7, direct and the appointed regional contact of disease eye.

First liquid hole 8 and second liquid hole 9 are located the avris and the bottom of bulb 7 respectively, first liquid hole 8 and 7 inside of bulb are linked together, and second liquid hole 9 and standpipe 10 are linked together, and the bottom of standpipe 10 and the inner wall of bulb 7 are nested connection, the bottom surface of montant 13 is provided with screw thread layer 14, and screw thread layer 14 and vertical cylinder 12 threaded connection, and vertical cylinder 12 and the cross-section are the 11 fixed connection of second valve block of square structure, the perpendicular fixed mounting of sleeve 16 is in the center department of clamp plate 5, its inner wall and 15 threaded connection of fluted bar, and 15 integration of fluted bar are connected on montant 13.

Example 5

a method for using a conjunctival sac disinfection solution comprises the steps of putting the conjunctival sac disinfection solution prepared in an embodiment 2 into a conjunctival sac washing and disinfecting device in an embodiment 4, directly opening a sterile table by a circulating nurse, carrying out washing operation under a sterile environment by an assistant or a main knife, moving a ball head 7 of the device integrally to the vicinity of an area to be disinfected during operation, pressing a pressing plate 5 downwards by using fingers under the premise of holding an outer barrel 1 by a single hand, driving a first valve block 3 to synchronously move downwards by the pressing plate 5 through a pressing rod 4 in the figure 1, so that a disinfection solution between the outer barrel 1 and an inner barrel 2 enters the ball head 7 in the figure 2 through a liquid outlet pipe 6, flows out from a first liquid hole 8 directly communicated with the inside of the ball head 7 and directly contacts with a designated area of eyes of a patient, correspondingly, as shown in the figure 4, when the pressing plate 5 moves downwards, a sleeve 16 fixedly installed at the center of the pressing plate moves downwards at the same time, under the transmission effect of sleeve 16 and twist bar 15, twist bar 15 can drive montant 13 and rotate together, when montant 13 in fig. 1 rotates, under the screw thread layer 14 and the screw thread transmission effect of vertical cylinder 12 of its bottom, vertical cylinder 12 can drive second valve piece 11 and shift up in step, therefore the inner space of inner tube 2 is in the negative pressure state, and be in the negative pressure state with its standpipe 10 that is linked together equally, consequently wash the antiseptic solution after the use in the eye region and other impurity can be inhaled to standpipe 10 and inner tube 2 via second liquid hole 9, thereby realize the purpose of the synchronous liquid outlet of same bulb 7.

Test examples

1. Comparison of performance of the povidone iodine solution and the conjunctival sac washing disinfectant

1.1 test methods

200 patients with ophthalmic surgery are clinically collected, 200 affected eyes are randomly divided into 2 groups, povidone iodine solution prepared on site and the conjunctival sac washing disinfectant are respectively used for disinfection and washing during the last washing and disinfection before surgery, and the patients are asked for the comfort level of the washing liquid after the surgery.

1.2 test data

The postoperative return visit results show that the number of cases of discomfort of the ocular surface of the patients using the conjunctival sac washing and disinfecting solution group is 31, and 64 cases of conjunctival sac washing solution are matched at present, and the significant difference is achieved (P is less than 0.05).

1.3 test results

From the data, the contrast effect of the comfort degree of the conjunctival sac washing and disinfecting solution is obviously superior to that of the existing povidone iodine solution in clinical application, and the conjunctival sac washing and disinfecting solution is worthy of clinical popularization.

2. Stability and timeliness testing

2.1 test methods

Under the same environment, the effective iodine concentration percentage content (C/%) of the conjunctival sac washing and disinfecting solution and the ready-prepared povidone iodine solution in different time periods under the same sterilization specification plate (5cmx5cm) is respectively detected at 25 ℃, 30 ℃, 35 ℃, 40 ℃ and 45 ℃.

2.2 test data

Specific test data are shown in tables 1 and 2.

Table 1 shows the effective iodine percentage (C/%) of the copovidone iodine flushing fluid

	1h	3h	5h	10h	15h	20h	30h	40h	50h	60h
											25℃	100	100	99.9	99.9	99.5	99.17	98.78	96.68	94.23	90.21
30℃	100	100	99.34	99.11	99	98.79	96.8	94.92	91.23	90
											35℃	100	99.98	99.21	99.33	99.12	99.1	96.12	94.21	91	89.99
40℃	100	99.2	98.48	98.1	97.55	92.23	89.14	84.17	90	88.2
											45℃	100	99.32	98.23	97.87	96.44	91.59	87.69	82.28	89.99	87

TABLE 2 effective iodine percentage (C/%) of conjunctival sac washing disinfectant

	1h	3h	5h	10h	15h	20h	30h	40h	50h	60h
											25℃	100	100	99.94	99.99	99.97	99.92	99.93	99.92	99.99	99.92
30℃	100	100	99.91	99.31	99.9	99.89	99.87	99.82	99.92	99.91
											35℃	100	99.99	99.91	99.83	99.72	99.71	99.52	99.51	99.34	99.33
40℃	100	100	99.48	99.5	99.55	99.43	99.44	99.37	99.34	99.26
											45℃	100	99.99	99.63	99.57	99.49	99.59	99.69	99.38	99.29	99.21

2.3 test results

Through experimental comparison and analysis, under the same condition, detection results show that the effective iodine content of the conjunctival sac washing disinfectant is greater than that of the existing povidone-iodine solution under different temperature environments, and the stability of the conjunctival sac washing disinfectant is superior to that of the existing povidone-iodine solution.

It will be evident to those skilled in the art that the invention is not limited to the details of the foregoing illustrative embodiments, and that the present invention may be embodied in other specific forms without departing from the spirit or essential attributes thereof. The present embodiments are therefore to be considered in all respects as illustrative and not restrictive, the scope of the invention being indicated by the appended claims rather than by the foregoing description, and all changes which come within the meaning and range of equivalency of the claims are therefore intended to be embraced therein, and any reference signs in the claims are not intended to be construed as limiting the claim concerned.

The above description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the present invention, and any modifications, equivalents, improvements and the like that are within the spirit and principle of the present invention should be included in the scope of the present invention.

Claims

1. A conjunctival sac disinfection solution, which is characterized in that: the povidone iodine-containing water-soluble type water.

2. The conjunctival sac disinfection solution of claim 1, wherein: comprises the following raw materials in percentage by weight: povidone iodine 0.14-0.96%, iminodisuccinic acid sodium 0.025-0.125%, potassium iodate 0.12-0.96%, potassium iodide 0.023-0.23%, sodium hydroxide 0.015-0.24%, sodium chloride 0.034-0.12%, potassium chloride 0.0034-0.086%, calcium chloride 0.00132-0.012%, and purified water 97.3-99.6%.

3. The utility model provides a conjunctival sac washes degassing unit, includes urceolus (1), drain pipe (6) and bulb (7), its characterized in that: the inner cylinder (2) is arranged in the outer cylinder (1), central axes of the inner cylinder and the outer cylinder are on the same vertical line, a first valve block (3) which is horizontally distributed is arranged between the inner wall of the outer cylinder (1) and the outer wall of the inner cylinder (2), a compression rod (4) which is vertically distributed is arranged on the upper end face of the first valve block (3), the compression rod (4) is connected to the top end of the outer cylinder (1) in a sliding manner, the top end of the compression rod (4) is arranged on the lower end face of a pressing plate (5), a liquid outlet pipe (6) is connected to the bottom end of the outer cylinder (1) in a threaded manner, a ball head (7) is integrally connected to the bottom end of the liquid outlet pipe (6), a first liquid hole (8) and a second liquid hole (9) are formed in the ball head (7), a vertical pipe (10) which is vertically distributed is arranged in the inner cylinder (7), the top end of the vertical pipe (10) is arranged at the bottom end of, and the up end of second valve piece (11) is connected through the bottom of vertical section of thick bamboo (12) and montant (13) to the top of montant (13) is passed urceolus (1) and is extended to inside sleeve (16), and the middle section of montant (13) and the top of urceolus (1) are for rotating the connection.

4. The conjunctival sac irrigation and disinfection device of claim 3, wherein: the outer edge and the inner edge of the first valve block (3) are respectively of a circular structure and a square structure, two side faces of the first valve block are respectively attached to the outer cylinder (1) and the inner cylinder (2), and the top end of the inner cylinder (2) with the square structure in section is in sealing connection with the outer cylinder (1).

5. The conjunctival sac irrigation and disinfection device of claim 3, wherein: first liquid hole (8) and second liquid hole (9) are located the avris and the bottom of bulb (7) respectively, and first liquid hole (8) and bulb (7) are inside to be linked together, and second liquid hole (9) and standpipe (10) are linked together to the bottom of standpipe (10) and the inner wall of bulb (7) are nested connection.

6. The conjunctival sac irrigation and disinfection device of claim 3, wherein: the bottom surface of the vertical rod (13) is provided with a thread layer (14), the thread layer (14) is in threaded connection with the vertical cylinder (12), and the vertical cylinder (12) is fixedly connected with the second valve block (11) with a square section.

7. The conjunctival sac irrigation and disinfection device of claim 3, wherein: the sleeve (16) is vertically and fixedly arranged at the center of the pressing plate (5), the inner wall of the sleeve is in threaded connection with the twist rod (15), and the twist rod (15) is integrally connected to the vertical rod (13).

8. A method for using a conjunctival sac disinfection solution, which is characterized by comprising the following steps: and filling the conjunctival sac disinfection solution into a conjunctival sac washing and disinfecting device, and directly washing in an aseptic environment.