CN110558564A - 一种胃肠内营养消化吸收调节剂 - Google Patents
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Abstract
本发明公开一种胃肠内营养消化吸收调节剂，属于保健食品技术领域，是由低脂柑橘果胶、卡拉胶、低聚糖、猕猴桃提取物和水组成的水溶液，所述低脂柑橘果胶的质量浓度为40‑120g/L，所述卡拉胶的质量浓度为5‑15g/L，所述低聚糖的质量浓度为10‑30g/L，所述猕猴桃提取物的质量浓度为3‑8g/L。本发明的胃肠内营养消化吸收调节剂能增加胃肠内营养物的粘度、延长营养物质在消化系统中的停留时间、增强胃肠道蠕动、促进消化吸收，有效缓解经肠营养疗法病人由于胃食道逆流所导致的误咽性肺炎、呕吐和消化不良等症状。
Description
技术领域
本发明涉及功能性食品技术领域，特别涉及一种胃肠内营养消化吸收调节剂。
背景技术
为使胃肠道功能虚弱或吞咽功能障碍人群的营养支持得到切实有效的保证，商品化肠内和肠外营养制剂应运而生。食物或经肠营养剂导入管理时经常遇到营养物在消化系统中停留时间短、消化吸收不充分，且容易出现由于胃食道逆流所导致的误咽性肺炎、呕吐等症状。对此国内外目前没有特别有效的解决方案。
天然果胶(Citrus Pectin简称CP)是从水果果皮、果肉中提取的一种多糖复合物，其分子是以一种长链碳水化合物结构存在，分子量为5-30万Da，酯化度为20-75％。根据纯度形状等可分为食品级、医药级果胶，高脂、低脂果胶，高凝、中凝、低凝果胶。天然果胶是纯天然无毒副作用的水溶性膳食纤维，作为食品添加剂使用时，有很好的胶凝、稳定、乳化、增稠、悬浮功能。因此，将果胶用于半固化胃肠内营养物具有良好的应用前景。目前已经有多个关于果胶调节胃肠内营养物粘度的专利，市场上也出现了的相应的产品。但临床和动物实验表明，这类调节剂主要通过改变胃肠内营养物的物理性状来预防食物反流。然而受众人群往往伴有胃肠道消化能力弱，肠道菌群失调等问题，仅仅改变营养物粘度无法解决这些问题，还有可能带来消化不良、便秘等副作用。因此开发一种具有适度调节胃肠内营养物粘度、促进胃肠道蠕动、改善消化系统内环境功能的产品十分有必要。
发明内容
本发明提供一种胃肠内营养消化吸收调节剂，解决现有的胃肠内营养消化吸收调节剂无法促进营养物消化吸收的问题。
为解决上述技术问题，本发明的技术方案是这样实现的：
本发明提供一种胃肠内营养消化吸收调节剂，是由低脂柑橘果胶、卡拉胶、低聚糖、猕猴桃提取物和水组成的水溶液，所述低脂柑橘果胶的质量浓度为40-120g/L，所述卡拉胶的质量浓度为5-15g/L，所述低聚糖的质量浓度为10-30g/L，所述猕猴桃提取物的质量浓度为3-8g/L。
其中，优选地，所述低脂柑橘果胶的粘均分子量为10000-150000，酯化度为5％-40％。
其中，优选地，所述低聚糖为低聚异麦芽糖、低聚果糖、低聚木糖、低聚半乳糖、大豆低聚糖或甲壳低聚糖中的一种或几种。
其中，优选地，所述猕猴桃提取物的制备方法，包括下述步骤：
将猕猴桃洗净去皮后置于研钵中研磨破碎，添加2倍量的蒸馏水，85℃加热4h，过滤，滤液于3000r/min离心10min，取上清，4℃静置1d后于3000r/min离心10min，留上清得猕猴桃水提物。
本发明的有益效果：
1、本发明能有效缓解经肠营养疗法病人由于胃食道逆流所导致的误咽性肺炎、呕吐等症状。
2、本发明在低脂柑橘果胶和卡拉胶中加入低聚糖，具有促进营养物质合成和吸收、恢复微生态失调者的肠道正常菌群、维持肠功能正常运行、抑制病原菌和腐败菌的生长、减少有害腐败物质和致癌物质的作用，并且还具有适宜的甜度和黏度，与低脂柑橘果胶、卡拉胶具有协同作用，可有效的增加胃肠营养液粘度，防治反流。
3、本发明并加入猕猴桃提取物，能有效增强胃肠道蠕动，促进营养物消化吸收，并能与果胶等协同作用，预防食物反流。
4、本发明胃肠内营养消化吸收调节剂效果好、成本低、原料有机环保、配比简单、无副作用。
具体实施方式
下面将结合本发明实施例，对本发明实施例中的技术方案进行清楚、完整地描述，显然，所描述的实施例仅仅是本发明一部分实施例，而不是全部的实施例。基于本发明中的实施例，本领域普通技术人员在没有做出创造性劳动前提下所获得的所有其它实施例，都属于本发明保护的范围。
下述实施例中猕猴桃提取物的制备方法，包括下述步骤：
将猕猴桃洗净去皮后置于研钵中研磨破碎，添加2倍量的蒸馏水，85℃加热4h，过滤，滤液于3000r/min离心10min，取上清，4℃静置1d后于3000r/min离心10min，留上清得猕猴桃水提物。
实施例1
本实施例提供一种胃肠内营养消化吸收调节剂，是由低脂柑橘果胶、卡拉胶、低聚异麦芽糖、猕猴桃提取物和水组成的水溶液，所述低脂柑橘果胶的质量浓度为50g/L，所述卡拉胶的质量浓度为10g/L，所述低聚异麦芽糖的质量浓度为20g/L，所述猕猴桃提取物的质量浓度为5g/L。
其中，所述低脂柑橘果胶的粘均分子量为10000，酯化度为5％。
本实施例胃肠内营养消化吸收调节剂的制备方法，包括下述步骤：
(1)取低脂柑橘果胶50g和卡拉胶10g，加入到85℃的600ml水中，水浴保持90min，然后800rpm搅拌2h，即得到均匀混合溶液；
(2)取猕猴桃提取物5g和低聚异麦芽糖20g加入混合溶液中，溶液补水至1L，搅拌均匀，即得。
本实施例的胃肠内营养消化吸收调节剂用NDJ-8S型粘度计(上海方瑞仪器有限公司)，在25℃的液体温度测定样品的粘度，测得粘度值5mPa·s。
实施例2
本实施例提供一种胃肠内营养消化吸收调节剂，是由低脂柑橘果胶、卡拉胶、低聚果糖、猕猴桃提取物和水组成的水溶液，所述低脂柑橘果胶的质量浓度为40g/L，所述卡拉胶的质量浓度为15g/L，所述低聚果糖的质量浓度为10g/L，所述猕猴桃提取物的质量浓度为8g/L。
其中，所述低脂柑橘果胶的粘均分子量为50000，酯化度为20％。
本实施例胃肠内营养消化吸收调节剂的制备方法，包括下述步骤：
(1)取低脂柑橘果胶40g和卡拉胶15g，加入到85℃的600ml水中，水浴保持90min，然后800rpm搅拌2h，即得到均匀混合溶液；
(2)取猕猴桃提取物8g和低聚果糖10g加入混合溶液中，溶液补水至1L，搅拌均匀，即得。
本实施例的胃肠内营养消化吸收调节剂用NDJ-8S型粘度计(上海方瑞仪器有限公司)，在25℃的液体温度测定样品的粘度，测得粘度值6mPa·s。
实施例3
本实施例提供一种胃肠内营养消化吸收调节剂，是由低脂柑橘果胶、卡拉胶、低聚半乳糖、猕猴桃提取物和水组成的水溶液，所述低脂柑橘果胶的质量浓度为120g/L，所述卡拉胶的质量浓度为5g/L，所述低聚半乳糖的质量浓度为30g/L，所述猕猴桃提取物的质量浓度为3g/L。
其中，所述低脂柑橘果胶的粘均分子量为80000，酯化度为25％。
本实施例胃肠内营养消化吸收调节剂的制备方法，包括下述步骤：
(1)取低脂柑橘果胶120g和卡拉胶5g，加入到85℃的600ml水中，水浴保持90min，然后800rpm搅拌2h，即得到均匀混合溶液；
(2)取猕猴桃提取物3g和低聚半乳糖30g加入混合溶液中，溶液补水至1L，搅拌均匀，即得。
本实施例的胃肠内营养消化吸收调节剂用NDJ-8S型粘度计(上海方瑞仪器有限公司)，在25℃的液体温度测定样品的粘度，测得粘度值7mPa·s。
实施例4
本实施例提供一种胃肠内营养消化吸收调节剂，是由低脂柑橘果胶、卡拉胶、甲壳低聚糖、猕猴桃提取物和水组成的水溶液，所述低脂柑橘果胶的质量浓度为45g/L，所述卡拉胶的质量浓度为12g/L，所述甲壳低聚糖的质量浓度为15g/L，所述猕猴桃提取物的质量浓度为6g/L。
其中，所述低脂柑橘果胶的粘均分子量为100000，酯化度为30％。
本实施例胃肠内营养消化吸收调节剂的制备方法，包括下述步骤：
(1)取低脂柑橘果胶45g和卡拉胶12g，加入到85℃的600ml水中，水浴保持90min，然后800rpm搅拌2h，即得到均匀混合溶液；
(2)取猕猴桃提取物6g和甲壳低聚糖15g加入混合溶液中，溶液补水至1L，搅拌均匀，即得。
本实施例的胃肠内营养消化吸收调节剂用NDJ-8S型粘度计(上海方瑞仪器有限公司)，在25℃的液体温度测定样品的粘度，测得粘度值4mPa·s。
实施例5
本实施例提供一种胃肠内营养消化吸收调节剂，是由低脂柑橘果胶、卡拉胶、低聚木糖、大豆低聚糖、猕猴桃提取物和水组成的水溶液，所述低脂柑橘果胶的质量浓度为55g/L，所述卡拉胶的质量浓度为8g/L，所述大豆低聚糖的质量浓度为15g/L，所述低聚木糖的质量浓度为10g/L，所述猕猴桃提取物的质量浓度为5g/L。
其中，所述低脂柑橘果胶的粘均分子量为150000，酯化度为40％。
本实施例胃肠内营养消化吸收调节剂的制备方法，包括下述步骤：
(1)取低脂柑橘果胶55g和卡拉胶8g，加入到85℃的600ml水中，水浴保持90min，然后800rpm搅拌2h，即得到均匀混合溶液；
(2)取猕猴桃提取物5g、低聚糖25g加入混合溶液中，溶液补水至1L，搅拌均匀，即得。
本实施例的胃肠内营养消化吸收调节剂用NDJ-8S型粘度计(上海方瑞仪器有限公司)，在25℃的液体温度测定样品的粘度，测得粘度值6mPa.s。
性能试验
一、组合物样品粘度稳定性
测试本发明的胃肠内营养消化吸收调节剂在放置1个月和3个月、6个月、12个月粘度稳定性(表1)。
用NDJ-8S型粘度计(上海方瑞仪器有限公司)，在25℃的液体温度测定样品的粘度，测得粘度值。
表1、实施例溶液粘度稳定性测试结果
由上述数据可以看出，本发明的胃肠内营养消化吸收调节剂放置12个月的过程中，无明显沉淀产生，粘度无明显变化。
二、体外模拟实验
通过调节溶液pH在体外模拟胃消化食物时的内环境(pH3.5)，测试本发明的粘度调节剂与肠内营养乳剂(华瑞肠内营养乳剂-瑞能)在模拟胃环境下的增稠效果。
用NDJ-8S型粘度计(上海方瑞仪器有限公司)，在37℃的液体温度测定样品的粘度，测得粘度值(表2)。
表2、实施例粘度调节效果测试结果
| 3分钟后(mPa·s) | 15分钟后(mPa·s) | 60分钟后(mPa·s) | |
| 实施例1 | 1560 | 1590 | 1620 |
| 实施例2 | 1620 | 1640 | 1610 |
| 实施例3 | 1570 | 1590 | 1580 |
| 实施例4 | 1610 | 1630 | 1600 |
| 实施例5 | 1590 | 1600 | 1620 |
由上述数据可以看出，本发明的胃肠内营养消化吸收调节剂与肠内营养乳剂在体外模拟胃环境下混合后能迅速提升粘度值，且十分稳定。
三、离体肠断动力学实验
选用BL-420F生物机能实验仪与JH-2型肌张力传感器连接，观察和记录(37±0.5℃)麦氏浴槽中离体肠段的运动。以台氏液(37±0.5℃)为基础对照、肾上腺素(0.01％)为阴性对照、乙酰胆碱(0.01％)为阳性对照，分别观测实施例和对照例对小鼠离体肠段运动的影响(见表3)。
表3、实施例和对照例对小鼠离体肠段运动的测试结果
| 分组 | 处理(1ml/次) | 收缩频率(次/min) | 收缩强度(g) |
| 1 | 台氏液 | 22.3±2.0 | 4.8±0.7 |
| 2 | 肾上腺素(0.01％) | 14.4±0.6 | 5.6±1.1 |
| 3 | 乙酰胆碱(0.01％) | 52.2±1.1 | 4.8±0.1 |
| 4 | 实施例1 | 95.3±1.5 | 5.2±0.2 |
| 5 | 实施例2 | 105.3±1.2 | 5.5±0.1 |
| 6 | 实施例3 | 81.4±1.3 | 4.6±0.2 |
| 7 | 实施例4 | 97.3±1.5 | 5.1±0.2 |
| 8 | 实施例5 | 94.3±1.6 | 5.0±0.3 |
由上述数据可以看出，本发明的胃肠内营养消化吸收调节剂能有效提高肠段收缩频率，促进肠道蠕动。
四、动物实验
选健康昆明种小鼠70只，雌雄各半，随机分成空白对照组、实验对照组和5个实验组。各组小鼠禁食不禁水16h后，按表4方案饲喂。30min后立即脱颈椎处死小鼠，打开腹腔分离肠系膜，剪取上端自幽门、下端至回盲部的肠管，将小肠平铺于白色瓷盘中，用生理盐水洗去表面血迹，轻轻将小肠拉成直线，测量肠管长度为“小肠总长度”，从幽门至酚红前沿为“肠道蠕动长度”(表5)。
表4、小鼠肠道推进实验方案
*注：该果胶溶液为不含猕猴桃提取液和低聚糖的实施例1溶液。
表5、小鼠肠道推进实验测试结果
| 组别 | 小鼠数量(n) | 小肠总长度(cm) | 肠蠕动长度(cm) |
| 空白对照组 | 10 | 51.72±1.22 | 51.35±1.31 |
| 实验对照组 | 10 | 51.72±1.22 | 28.30±3.31 |
| 实施例1 | 10 | 53.25±3.24 | 41.27±4.89 |
| 实施例2 | 10 | 51.90±2.22 | 44.27±2.62 |
| 实施例3 | 10 | 50.18±4.25 | 35.56±4.11 |
| 实施例4 | 10 | 53.43±3.22 | 42.37±2.72 |
| 实施例5 | 10 | 52.38±3.17 | 34.86±3.51 |
肠道推进实验结果表明，本发明的胃肠内营养消化吸收调节剂能有效延长胃肠内营养剂在消化系统中的停留时间；在促进胃肠道蠕动方面本发明明显优于单纯的果胶溶液。
以上所述仅为本发明的较佳实施例而已，并不用以限制本发明，凡在本发明的精神和原则之内，所作的任何修改、等同替换、改进等，均应包含在本发明的保护范围之内。
Claims (4)
1.一种胃肠内营养消化吸收调节剂，其特征在于是由低脂柑橘果胶、卡拉胶、低聚糖、猕猴桃提取物和水组成的水溶液，所述低脂柑橘果胶的质量浓度为40-120g/L，所述卡拉胶的质量浓度为5-15g/L，所述低聚糖的质量浓度为10-30g/L，所述猕猴桃提取物的质量浓度为3-8g/L。
2.根据权利要求1所述的一种胃肠内营养调节剂，其特征在于：所述低脂柑橘果胶的粘均分子量为10000-150000，酯化度为5％-40％。
3.根据权利要求1所述的一种胃肠内营养调节剂，其特征在于：所述低聚糖为低聚异麦芽糖、低聚果糖、低聚木糖、低聚半乳糖、大豆低聚糖、甲壳低聚糖中的一种或几种。
4.根据权利要求1所述的一种胃肠内营养调节剂，其特征在于：所述猕猴桃提取物的制备方法，包括下述步骤：
将猕猴桃洗净去皮后置于研钵中研磨破碎，添加2倍量的蒸馏水，85℃加热4h，过滤，滤液于3000r/min离心10min，取上清液，4℃静置1d后于3000r/min离心10min，留上清液得猕猴桃水提物。
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| US20150004149A1 (en) * | 2011-12-15 | 2015-01-01 | Nestec S.A. | Cohesive thin liquids to promote safe swallowing in dysphagic patients |
| WO2014010577A1 (ja) * | 2012-07-09 | 2014-01-16 | キユーピー株式会社 | ペクチン水溶液 |
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