CN110490966A - Biological 3D printing forward direction stent model design method - Google Patents
Biological 3D printing forward direction stent model design method Download PDFInfo
- Publication number
- CN110490966A CN110490966A CN201810497864.7A CN201810497864A CN110490966A CN 110490966 A CN110490966 A CN 110490966A CN 201810497864 A CN201810497864 A CN 201810497864A CN 110490966 A CN110490966 A CN 110490966A
- Authority
- CN
- China
- Prior art keywords
- forward direction
- tissue
- bracket
- printing
- design method
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
- G06T17/00—Three dimensional [3D] modelling, e.g. data description of 3D objects
Landscapes
- Physics & Mathematics (AREA)
- Engineering & Computer Science (AREA)
- Computer Graphics (AREA)
- Geometry (AREA)
- Software Systems (AREA)
- General Physics & Mathematics (AREA)
- Theoretical Computer Science (AREA)
- Prostheses (AREA)
Abstract
The present invention provides a kind of biological 3D printing forward direction stent model design method comprising following steps: treating scanned position using scanning device and is scanned initial data of the acquisition containing position to be scanned；Image segmentation result is obtained by image processing techniques according to the initial data containing position to be scanned；It is obtained and tissue three-dimensional model according to the reconstruct of described image segmentation result；Bracket blank is generated according to the tissue three-dimensional modelling；It is designed according to the bracket blank and generates biological 3D printing forward direction stent model.Biological 3D printing forward direction stent model design method of the invention, the foundation based on patient's original structure model, can from bottom to top, the bracket that matches of Top-Down Design and patient tissue.
Description
[technical field]
The present invention relates to biological 3D printing technique field more particularly to a kind of biological 3D printing forward direction stent model design sides
Method.
[background technique]
Biological 3D printing is based on the threedimensional model of required design, by the way that software hierarchy is discrete and the molding side of numerical control
Method, positioning assembly biomaterial (living cells can be also blended in the biomaterial of customization), manufacture of intraocular are implanted into bracket, organizer
The rapid shaping technique of the biomedical products such as official and medical auxiliary tool.Biological 3D printing is most developed in rapid shaping technique
One of application field of potentiality.
The construction of individual, pathological condition are not exactly the same, there is personalized, differentiation characteristic, and 3D printing technique has
There is quick, accurate, personalized, differentiation and be particularly suitable for the characteristic of manufacture complicated shape entity, therefore 3D printing can be with life
Object material, cell culture, medical imaging and software ancillary technique combine, for the specific anatomic construction of patient, physiological function
The medical products such as Artificial Intervention bracket, histoorgan and medical auxiliary tool are designed and manufactured with Treatment need, are personalized medicine
And precisely medical treatment provides breakthrough treatment new technology.
The vital movements such as growth and breeding, the metabolism of cell need certain interior environment, and biomaterial scaffolds are cell
Provide the place of similar vivo environment.Bracket is printed by the biomaterial of degradable absorption, with corresponding mixing with cells
At vitro tissue or organ model, it is placed in culture in incubator or experimental animal body, finally obtains ideal printing product.
The macrostructure of bracket is embodied in global shape (such as patient and organ individual difference, anatomy of histoorgan
Feature), microstructure is reflected in the inside structure (such as pore size, shape, spatial distribution and porosity interconnection) of bracket, nanoscale
Construction shows the surface modification (the biomolecule adhesive of such as cell adhesion, proliferation and differentiation) of bracket.Ideal cartilage group
Good histocompatbility should be had the following characteristics that by knitting engineering scaffold material；Good biodegradability；Effective surface is living
Property；Certain plasticity；There is three-dimensional porous structure.
How efficient design rationally, precisely, effectively, and with the matched biological 3D printing bracket of patient tissue, to realize
The biological 3D printing of bracket obtains physical model and carries out various medical applications, is of great significance and is worth.
[summary of the invention]
In order to solve the problems in the prior art, the purpose of the present invention is to provide a kind of biological 3D printing forward direction bracket moulds
Type design method includes the following steps: that scanned position is treated using scanning device is scanned original of the acquisition containing position to be scanned
Beginning data；Image segmentation result is obtained by image processing techniques according to the initial data containing position to be scanned；According to the figure
As segmentation result reconstruct obtains and tissue three-dimensional model；Bracket blank is generated according to the tissue three-dimensional modelling；According to institute
It states the design of bracket blank and generates biological 3D printing forward direction stent model.
Further, included the following steps: according to the process that the tissue three-dimensional modelling generates bracket blank with institute
It states and refers to based on tissue three-dimensional model, pass through selection polyhedron, construct multi-panel unit cell basic geometry, the multi-panel unit cell
It is superimposed automatically according to space arrangement sequence, obtains bracket blank, the characteristic size of the bracket blank is greater than the tissue three-dimensional
The characteristic size of model.
Further, the process for generating biological 3D printing forward direction bracket porous support model is designed according to the bracket blank
Include the following steps: to carry out boolean's intersection operation by the bracket blank and tissue three-dimensional model, obtaining has anatomical shape
Biological 3D printing forward direction stent model.
Further, the scanning device is CT or nuclear magnetic resonance equipment, and the Medical Image Processing includes image
Pretreatment, image segmentation, post processing of image.
Further, the characteristic size of the bracket blank includes the length of bracket blank, the tissue three-dimensional mould
The characteristic size of type includes the length of tissue three-dimensional model.
Further, the multi-panel unit cell basic geometry be porous structure, the unit cell aperture of the porous structure and
Stud size is adjustable.
Further, the biological 3D printing forward direction stent model has the cooperation being bonded completely with tissue corresponding site
Face.
The present invention uses Top-Down Design supporting structure, it is fixed can to learn result according to each patient image under area of computer aided
Individuation bracket processed, in the form of complying fully with the bracket of patient or doctor's demand, and have speed fast, adjustable porosity and
The advantages such as rack mechanical characteristic.
[specific embodiment]
By 64 row's helical CT scanners, angiography CT image is obtained, through image preprocessing, image segmentation, post-processing,
Vessel segmentation is obtained, and three-dimensional modeling acquisition is carried out by marching cubes algorithm and organizes consistent blood with patient vessel
Pipe threedimensional model.
Based on blood vessel three-dimensional model, polyhedron is selected, the multi-panel unit cell basic geometry of intravascular stent is constructed；It is logical
It crosses to the multi-panel unit cell of construction according to the automatic superposition of longitudinal arrangement sequence of blood vessel axial direction, obtains bracket blank, the branch
The length characteristic size of frame blank is greater than the length characteristic size of the blood vessel three-dimensional model.By by the bracket
Blank and blood vessel three-dimensional model carry out boolean's intersection operation, obtain the biological 3D printing forward direction stent model with anatomical shape.
The biological 3D printing forward direction bracket mould that biology 3D printing forward direction stent model design method according to the present invention obtains
Type can match with patient tissue to greatest extent, obtain entity bracket using biological 3D printing preparation method, realize personalized
Precisely medical treatment.
To sum up, the above is merely preferred embodiments of the present invention, should not be limited the scope of the invention with this, i.e., it is all according to
Simple equivalent changes and modifications made by claims of the present invention and present specification should all still belong to the present invention
The range that patent covers.
Claims (7)
1. a kind of biology 3D printing forward direction stent model design method, characterized by the following steps:
Scanned position is treated using scanning device and is scanned initial data of the acquisition containing position to be scanned；
Image segmentation result is obtained by image processing techniques according to the initial data containing position to be scanned；
It is obtained and tissue three-dimensional model according to the reconstruct of described image segmentation result；
Bracket blank is generated according to the tissue three-dimensional modelling；
It is designed according to the bracket blank and generates biological 3D printing forward direction stent model.
2. biology 3D printing forward direction stent model design method as described in claim 1, it is characterised in that: according to the tissue
The process that threedimensional model design generates bracket blank includes the following steps: to refer to based on the tissue three-dimensional model, passes through
Polyhedron is selected, multi-panel unit cell basic geometry is constructed, the multi-panel unit cell is superimposed automatically according to space arrangement sequence, is obtained
Bracket blank, the characteristic size of the bracket blank are greater than the characteristic size of the tissue three-dimensional model.
3. biology 3D printing forward direction stent model design method as claimed in claim 2, it is characterised in that: according to the bracket
The process that blank design generates biological 3D printing forward direction bracket porous support model includes the following steps: through the bracket blank
Boolean's intersection operation is carried out with tissue three-dimensional model, obtains the biological 3D printing forward direction stent model with anatomical shape.
4. biology 3D printing forward direction stent model design method as claimed in claim 3, it is characterised in that: the scanning device
For CT or nuclear magnetic resonance equipment, the Medical Image Processing includes image preprocessing, image segmentation, post processing of image.
5. biology 3D printing forward direction stent model design method as claimed in claim 3, it is characterised in that: the bracket blank
Characteristic size include bracket blank length, the characteristic size of the tissue three-dimensional model includes tissue three-dimensional model
Length.
6. biology 3D printing forward direction stent model design method as claimed in claim 5, it is characterised in that: the multi-panel unit cell
Basic geometry is porous structure, and the unit cell aperture of the porous structure and stud size are adjustable.
7. biology 3D printing forward direction stent model design method as claimed in claim 6, it is characterised in that: the biology 3D is beaten
Printing positive stent model has the mating surface being bonded completely with tissue corresponding site.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810497864.7A CN110490966A (en) | 2018-05-14 | 2018-05-14 | Biological 3D printing forward direction stent model design method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810497864.7A CN110490966A (en) | 2018-05-14 | 2018-05-14 | Biological 3D printing forward direction stent model design method |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN110490966A true CN110490966A (en) | 2019-11-22 |
Family
ID=68545428
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810497864.7A Withdrawn CN110490966A (en) | 2018-05-14 | 2018-05-14 | Biological 3D printing forward direction stent model design method |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN110490966A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2023185405A1 (en) * | 2022-04-02 | 2023-10-05 | 南京前知智能科技有限公司 | Design method for 3d printed denture framework, and apparatus and storable medium |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105147416A (en) * | 2015-09-23 | 2015-12-16 | 深圳市艾科赛龙科技有限公司 | Construction method and construction system of tissue and organ defect portion bridging object |
-
2018
- 2018-05-14 CN CN201810497864.7A patent/CN110490966A/en not_active Withdrawn
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105147416A (en) * | 2015-09-23 | 2015-12-16 | 深圳市艾科赛龙科技有限公司 | Construction method and construction system of tissue and organ defect portion bridging object |
Non-Patent Citations (1)
| Title |
|---|
| CHI-MUN CHEAH 等: "Automatic Algorithm for Generating Complex Polyhedral Scaffold Structures for Tissue Engineering", 《TISSUE ENGINEERING》, vol. 10, no. 3, 9 July 2004 (2004-07-09), pages 595 - 610, XP002691483, DOI: 10.1089/107632704323061951 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2023185405A1 (en) * | 2022-04-02 | 2023-10-05 | 南京前知智能科技有限公司 | Design method for 3d printed denture framework, and apparatus and storable medium |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Yap et al. | 3D printed bio-models for medical applications | |
| Yao et al. | Three-dimensional printing: review of application in medicine and hepatic surgery | |
| Melchels et al. | CAD/CAM-assisted breast reconstruction | |
| Anastasiou et al. | 3D printing: Basic concepts mathematics and technologies | |
| CN103751852A (en) | Preparation method of three-dimensional artificial random porous structure tissue engineering scaffold | |
| Kucukgul et al. | 3D hybrid bioprinting of macrovascular structures | |
| CN105224759A (en) | A kind of human anatomic structure model, implant quick molding method | |
| CN105617465B (en) | A kind of biological support production method and biological support based on 3D printing | |
| CN104473705A (en) | Head maxillofacial bone implant and method for quickly molding same | |
| Fu et al. | Magnetic resonance imaging-three-dimensional printing technology fabricates customized scaffolds for brain tissue engineering | |
| US10400203B2 (en) | Method for producing living tissue and organ | |
| US20240367382A1 (en) | 3d bioprinting a medical device through freeform reversible embedding | |
| CN110393610B (en) | Three-layer composite bone implant prosthesis and preparation method thereof | |
| Mondy et al. | Computer-aided design of microvasculature systems for use in vascular scaffold production | |
| CN106039398A (en) | Preparation method of bionic artificial bone scaffold with micro-structure | |
| CN110490966A (en) | Biological 3D printing forward direction stent model design method | |
| Lim et al. | Three-dimensional bioprinting for bone and cartilage transplantation | |
| Nam et al. | Computer aided tissue engineering for modeling and design of novel tissue scaffolds | |
| Sahai et al. | Computer aided designing and finite element analysis for development of porous 3D tissue scaffold-a review | |
| Sahai et al. | Development and selection of porous scaffolds using computer-aided tissue engineering | |
| Raos et al. | Rapid prototyping and rapid machining of medical implants | |
| Fell et al. | Bio-hybrid soft robotic bioreactors for mimicking multi-axial femoropopliteal artery mechanobiology | |
| CN106178128A (en) | The individuation autologous tissue engineering sticking patch optimized based on Fluid Mechanics Computation | |
| Akbaş et al. | THREE DIMENSIONAL PRINTER APPLICATIONS IN THE HEALTH SECTOR: CURRENT SITUATION AND FUTURE | |
| Sun et al. | Application and Development of 3D Printing in Medical Field J |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| DD01 | Delivery of document by public notice | ||
| DD01 | Delivery of document by public notice |
Addressee: You Xiaoqing Document name: Notification of conformity |
|
| WW01 | Invention patent application withdrawn after publication | ||
| WW01 | Invention patent application withdrawn after publication |
Application publication date: 20191122 |