CN110461300A

CN110461300A - The gelatine composition of biological source

Info

Publication number: CN110461300A
Application number: CN201880022787.8A
Authority: CN
Inventors: B·斯沃博达; P·康蒂; R·弗朗西斯
Original assignee: Total Marketing Services SA
Current assignee: Total Energy Technologies
Priority date: 2017-03-20
Filing date: 2018-03-16
Publication date: 2019-11-15
Also published as: JP2020511484A; KR102705716B1; EP3600227A1; KR20190126000A; JP7514620B2; US20200054546A1; US12036307B2; WO2018172228A1; EP3378464A1

Abstract

The present invention relates to a kind of gelatine compositions, total weight relative to the gelatine composition, it includes :-at least at least one hydrocarbon ils of 50 weight %, wherein, total weight relative to the hydrocarbon ils, the weight content of isoparaffin is 90% to 100%, and the weight content of normal paraffin hydrocarbons is 0 to 10%, and the content of the carbon of biological source is greater than or equal to 90%；With-at least at least one gelling agent of 1 weight %, the gelling agent is selected from: i. is selected from the gel polymer of homopolymer and copolymer, the homopolymer and copolymer are obtained from selected from least one of isoprene, butadiene, styrene and (methyl) acrylate monomer, and its mixture, ii. non-polymer gelling agent.

Description

The gelatine composition of biological source

Technical field

The present invention relates to a kind of gelatine compositions, and it includes at least one to be classified as biodegradable, biological source And the hydrocarbon ils of mainly isoparaffin.

The invention further relates to beauty, skin care or medical composition and its uses comprising the gelatine composition.

The invention further relates to the gelatine compositions to prepare the purposes in beauty, skin care or drug products.

Background technique

Beauty exists in different forms.It can be emulsion form (by between the stable water phase of emulsifier and fatty phase Mixture), be also possible to complete water phase or completely anhydrous (only fatty phase).In order to increase quality in lotion or anhydrous product Or increasing the viscosity of fatty phase, those skilled in the art will use fatty phase gel, between non-polar oil and gelling agent Mixture.These gels are particularly useful for preparing gloss agent, lip gloss, skin cream or sunscreen product.But it exists in shield It sends out in product, depilatory cream and deodorant.

These gels can also be applied in pharmacy, residential care and general industry.

Therefore, non-polar gel is the mixture of non-polar oil and gelling agent.Non-polar oil can be mineral oil, plant Oil, silicone oil or isoparaffin.Gelling agent is most often polymer, such as ethylene/propene/styrol copolymer or butylene/second Alkene/styrol copolymer or polyisobutene, poly decene or isoprene copolymer (or others SEBS, SBS, SIS, TPE Deng).These copolymers are usually sold by Kraton or Kuraray company.

Most common gel is mineral oil base gel.Compatibility between these oil and copolymer is very good, actually total The non-polar conformations of polymers and these oily highly compatibles.The major defect of mineral oil base gel is: oily fossil sources and product Filamentary texture.

Document WO 02/05760 is related to a kind of beauty and/or physiological composition, it includes at least one powder compound and At least one pre-bonding condensation material.Document EP 1 584 322 is related to a kind of anhydrous cosmetic composition, it includes polymer gelling agent, Nonvolatile oil and poly methyl methacrylate particle.The two documents do not disclose the hydrocarbon of biological source defined in the present invention Oil.

In order to overcome the disadvantage (fossil or petrochemistry source), has studied vegetable oil or ester group gel and (such as applying In US 2011/0045983A1).Compatibility between oxygen-containing oil (such as ester or vegetable oil) and copolymer is bad, this may cause Composition is difficult to prepare.In addition, these esters are also chemical.For vegetable oil (effective biological source), in addition to copolymerization Except the poor compatibility of object, major defect also reside in change rot and to oxidation-sensitive, this is usually required using antioxidant. The unstability of these vegetable oil is particularly to be derived from a large amount of presence of the molecule comprising hetero atom and/or unsaturated bond.

Therefore, there is still a need for a kind of gelatine composition (or gel), it includes the fatty phases of biological source, in fatty phase There is good compatibility between forming compounds, and do not need addition antioxidant.

The applicant is it was unexpectedly observed that this demand can pass through the gelatine group of the new fatty phase with biological source It closes object to meet, the fat is mutually main comprising isoparaffin, and available stable composition.

The object of the present invention is to provide it is a kind of come biological origin raw material isoparaffin gelatine composition.

The present invention also aims to propose a kind of stable gelatine composition, there is the property for being suitable for its purposes Energy.

Summary of the invention

These purposes are achieved due to new gelatine composition.The present invention relates to a kind of gelatine composition, phases For the total weight of the gelatine composition, it includes:

At least at least one hydrocarbon ils of 50 weight %, wherein the total weight relative to the hydrocarbon ils, the weight of isoparaffin Content is 90% to 100%, and the weight content of normal paraffin hydrocarbons is 0 to 10%, and the content of the carbon of biological source is greater than or waits In 90%；With

At least at least one gelling agent of 0.5 weight %, the gelling agent are selected from:

I. selected from the gel polymer of homopolymer or copolymer, the homopolymer or copolymer include selected from isoprene, At least one of butadiene, styrene and (methyl) acrylate monomer,

Ii. non-polymer gelling agent.

According to embodiment of the present invention, gelling agent is the gel polymer selected from homopolymer or copolymer, described Homopolymer or copolymer include selected from least one of isoprene, butadiene, styrene and (methyl) acrylate monomer.

According to embodiment of the present invention, gel polymer is selected from homopolymer or copolymer, the homopolymer or total Polymers includes selected from least one of isoprene, butadiene and styrene monomer.

According to embodiment of the present invention, polymer is comprising at least one styrene monomer and selected from ethylene, third The copolymer of at least one of alkene, butadiene and isoprene monomer.

According to embodiment of the present invention, polymer is selected from star polymer, diblock copolymer, triblock copolymer Object, segmented copolymer, comb polymer, radial polymers and the combination of the latter.

According to embodiment of the present invention, polymer is selected from styrene/butadiene copolymers, styrene/isoamyl two Alkene copolymer, hydrogenated styrene/butadiene copolymer, hydrogenated styrene/isoprene copolymer, hydrogenated polyisoprene crosslinking Polymer, polyisoprene homopolymer, hydrogenated styrene thermoplastic homopolymer, liquid rubber and its mixture.

According to embodiment of the present invention, gelling agent is non-poly- in mineral filler, wax, ammonium salt and metal salt Close object gelling agent.

According to embodiment of the present invention, hydrocarbon ils is selected from the non-cyclic isoparaffins comprising 14 to 18 carbon atoms.

According to embodiment of the present invention, hydrocarbon ils includes:

Relative to the total weight of hydrocarbon ils, weight content is 90% to 100%, is preferably 95% to 100%, preferably 98% to 100% isoparaffin；

Content is the carbon of the biological source more than or equal to 95%, preferably greater than or equal to 98%, preferably 100%；

Relative to the total weight of hydrocarbon ils, weight content is less than or equal to 10%, is preferably less than or equal to 5%, preferably For the normal paraffin hydrocarbons less than or equal to 2%；And/or

Relative to the total weight of hydrocarbon ils, weight content is less than or equal to 1%, is preferably less than or equal to 0.5%, is excellent It is selected as the naphthenic compound less than or equal to 100ppm；And/or

Relative to the total weight of hydrocarbon ils, weight content is less than or equal to 500ppm, is preferably less than or equal to 300ppm, it is preferably less than or equal to 100ppm, more preferably less than or equal to 50ppm, is advantageously less than or equal to 20ppm's Aromatic compounds.

According to embodiment of the present invention, hydrocarbon ils:

According to the boiling temperature of standard ASTM D86 be 230 DEG C to 340 DEG C, preferably 235 DEG C to 330 DEG C, more preferably 240 DEG C to 325 DEG C；And/or

It is at least 60%, preferably at least 70% according to 28 days biodegradabilities that standard OECD 306 is measured, preferably It is at least 75%, even more preferably at east 80%；And/or

It is more than or equal to 110 DEG C according to the flash-point of standard EN ISO 2719.

According to embodiment of the present invention, hydrocarbon ils passes through in 80 DEG C to 180 DEG C of temperature and 50 to 160 bars of pressure Under catalytic hydrogenation is carried out to the deoxidation and/or isomerization of biological source charging method obtain.

According to embodiment of the present invention, the total weight relative to gelatine composition, gelatine composition include The hydrocarbon ils of 50 weight % to 99 weight %, preferably 60 weight % to 95 weight %, more preferably 70 weight % to 90 weight % With 1 weight % to 50 weight %, preferably 5 weight % to 40 weight %, more preferably described in 10 weight % to 30 weight % Gelling agent, the gelling agent are preferably selected from gel polymer.

The invention further relates to beauty, skin care or pharmaceutical composition, it includes at least one gelatine composition of the invention, Relative to the total weight of the composition, the amount of the gelatine composition is preferably 0.5% to 80%, preferably 1% to 50%, it is advantageously 5% to 30%.

According to embodiment of the present invention, beauty of the invention, skin care or pharmaceutical composition include:

At least one fatty material, selected from vegetable oil, the moisturizing cream composition hydrocarbon ils other than hydrocarbon ils, plant Rouge, fatty alcohol and ether, oily ester, alkane and silicone oil；And/or

It is preferably selected from least one additive of emulsifier.

The present invention also aims to gelatine composition of the invention or beauty of the invention, skin care or pharmaceutical composition Purposes in local application is especially used as care product, makeups articles, hair products, the cleansing product, perfume (or spice) of skin or hair Aquatic products, sunscreen product, lip care product such as lip gloss or lip gloss.

According to embodiment of the present invention, gelatine composition of the invention or beauty, skin care or pharmaceutical composition As antidotal agent.

The invention further relates to the methods for carrying out cosmetic treatments to skin, and this method includes at least one following steps: application (preferably passing through smearing) gelatine composition of the invention or beauty of the invention, skin care or pharmaceutical composition.

The present invention also aims to gelatine composition of the invention or beauty of the invention, skin care or pharmaceutical composition As drug.

According to one embodiment, gelatine composition of the invention or beauty of the invention, skin care or pharmaceutical composition As antioxidant and/or antifree radical agent and/or anti-inflammatory agent and/or anti-apoptotic agent and/or antibacterial agent and/or antimycotic Agent.

Specific embodiment

The present invention relates to a kind of gelatine composition, relative to the total weight of the gelatine composition, it includes:

I. the polymer selected from homopolymer or copolymer, the homopolymer or copolymer, which are obtained from, is selected from isoprene, fourth two At least one of alkene, styrene and (methyl) acrylate monomer,

Ii. non-polymer gelling agent is preferably selected from mineral filler, wax, ammonium salt and metal salt.

Gelatine composition of the invention, which can have, is classified as nonirritant, biodegradable and tasteless combination Object.

Gelatine composition of the invention can especially obtain stable beauty, skin care or pharmaceutical composition.Stability is special Lai Zi following facts: hydrocarbon ils defined in the present invention include low ratio, even substantially or entirely without unsaturated chemical combination Object and/or include heteroatomic compound.

Substantially, it should be noted that in specification and appended book, statement " between " must be understood as wrapping Include mentioned limit value.

Gelatine composition

According to embodiment of the present invention, gelatine composition of the invention includes:

- 50 weight % to 99.5 weight %, more preferable 60 weight % are to 99 weight %, preferably 70 weight % to 98 weights The hydrocarbon ils of %, more preferable 80 weight % to 95 weight %, even more preferably 85 weight % to 93 weight % are measured, and

- 0.5 weight % to 50 weight %, preferably 1 weight % to 40 weight %, preferably 2 weight % to 30 weight %, it is more excellent Select the gelling agent of 5 weight % to 20 weight %, even more preferably 7 weight % to 15 weight %.

- 0.5 weight % to 50 weight %, preferably 1 weight % to 40 weight %, preferably 2 weight % to 30 weight %, it is more excellent The gelling agent of 5 weight % to 20 weight %, even more preferably 7 weight % to 15 weight % is selected, homopolymer and copolymer are selected from, The homopolymer and copolymer include selected from least one of isoprene, butadiene, styrene and (methyl) acrylate Monomer.

According to embodiment of the present invention, the viscosity that gelatine composition is measured at 23 DEG C is (according in experimental section The method of description) it is 3 to 750,000mPa.s.

Therefore, gelatine composition of the invention will more preferably include single fat phase.

Hydrocarbon ils

Relative to the total weight of composition, gelatine composition of the invention more preferably include content be 50 weight % extremely 99.5 weight %, preferably 60 weight % are to 99 weight %, more preferably 70 weight % to 98 weight % and advantageously 80 weights Measure the hydrocarbon ils of % to 9 weight %.

A large amount of presence of hydrocarbon ils of the invention facilitate beauty, drug and/or the skin care quality of gelatine composition: to skin Suitable sense, nursing, gloss and the protection of skin.

Relative to the total weight of hydrocarbon ils, the hydrocarbon ils of gelatine composition of the invention preferably comprises weight content and is greater than or waits In 90%, preferably greater than or equal to 95% and the isoparaffinic compounds advantageously greater than or equal to 98%.

According to one embodiment, the isoparaffinic compounds being present in the hydrocarbon ils that the present invention uses include 12 to 30 Carbon atom, preferably 13 to 19 carbon atoms, more preferable 14 to 18 carbon atoms.

The hydrocarbon ils of gelatine composition of the invention preferably comprises weight content and is less than or equal to 10%, is preferably smaller than or waits In 5% and advantageously less than or equal to 2% normal paraffin hydrocarbons.

The hydrocarbon ils of gelatine composition of the invention advantageously comprises most of isoparaffin and small part normal paraffin hydrocarbons.This A little isoparaffins advantageously non-cyclic isoparaffins.It is highly preferred that the isoparaffin and normal chain of the hydrocarbon ils of gelatine composition The mass ratio of alkane is at least 12:1, preferably 15:1, and more preferably 20:1.Even more desirably, gelling of the invention The hydrocarbon ils for changing composition does not include any normal paraffin hydrocarbons.

According to one embodiment, hydrocarbon ils of the invention preferably comprises the isoparaffin that weight content is 90% to 100% With content be 0 to 10% normal paraffin hydrocarbons, preferably 95% to 100% isoparaffin and 0 to 5% normal paraffin hydrocarbons, it is more excellent It is selected as 98% to 100% isoparaffin and 0 to 2% normal paraffin hydrocarbons.

According to one embodiment, the hydrocarbon ils of gelatine composition of the invention preferably comprise weight content be 90% to The normal paraffin hydrocarbons that 100% isoparaffin and content is 0 to 10%, preferably 95% to 100% isoparaffin, selected from packet Containing 12 to 30 carbon atoms, more preferable 14 to 18 carbon atoms, more preferable 14 to 17 carbon atoms alkane.

According to one embodiment, the hydrocarbon ils implemented according to the present invention includes:

Relative to the total weight of hydrocarbon ils, total amount is the different alkane with 15 carbon atoms of 80 weight % to 98 weight % Hydrocarbon and isoparaffin with 16 carbon atoms, or

Relative to the total weight of hydrocarbon ils, total amount is the different alkane with 16 carbon atoms of 80 weight % to 98 weight % Hydrocarbon, the isoparaffin with 17 carbon atoms and the isoparaffin with 18 carbon atoms, or

Relative to the total weight of hydrocarbon ils, total amount is the different alkane with 17 carbon atoms of 80 weight % to 98 weight % Hydrocarbon and isoparaffin with 18 carbon atoms.

The hydrocarbon ils of gelatine composition of the invention preferably comprises weight content and is less than or equal to 1%, is preferably smaller than or waits In 0.5% and the naphthenic compound of more preferably less than or equal to 100ppm.

According to another preferred embodiment, the hydrocarbon ils of gelatine composition of the invention include weight content be 90% to 100% isoparaffin, the normal paraffin hydrocarbons and weight content that weight content is 0 to 10% are the cycloalkanes less than or equal to 1% Hydrocarbon.Preferably, hydrocarbon ils includes the isoparaffin that weight content is 95% to 100%, the normal paraffin hydrocarbons that weight content is 0 to 5% With the cycloalkane that weight content is less than or equal to 0.5%.It is highly preferred that it includes weight content be 98% to 100% it is different Alkane, the normal paraffin hydrocarbons and weight content that weight content is 0 to 2% are the cycloalkane less than or equal to 100ppm.

The hydrocarbon ils implemented in gelatine composition of the invention advantageously not aromatic-containing compound.Such as, it is appreciated that example It is such as less than or equal to 500ppm, preferably lower than or equal to by the weight content of the aromatic compound of UV spectroscopy measurements 300ppm, preferably lower than or equal to 100ppm, more preferably less than or equal to 50ppm, advantageously less than or equal to 20ppm.

The isoparaffin of hydrocarbon ils, normal paraffin hydrocarbons, cycloalkane and/or aromatic hydrocarbons weight content can be according to those skilled in the art Method well known to member determines.As non-limiting examples, it can be mentioned that gas chromatography analysis method.

According to another preferred embodiment, the hydrocarbon ils of gelatine composition of the invention include weight content be 90% to 100% isoparaffin, the normal paraffin hydrocarbons that weight content is 0 to 10%, weight content are the cycloalkane less than or equal to 1%, And weight content is the aromatic compounds less than or equal to 500ppm.Preferably, hydrocarbon ils include weight content be 95% to 100% isoparaffin, the normal paraffin hydrocarbons that weight content is 0 to 5%, weight content are the cycloalkane less than or equal to 0.5%, And weight content is less than or equal to 300ppm, preferably smaller than 100ppm, preferably smaller than 50ppm and advantageously below 20ppm Aromatic compounds.It is further preferred that hydrocarbon ils includes the isoparaffin that weight content is 95% to 100%, weight content is 0 to 5% Normal paraffin hydrocarbons and weight content be aromatic compounds less than or equal to 100ppm.It is highly preferred that it includes weight contents to be 98% to 100% isoparaffin, the normal paraffin hydrocarbons that weight content is 0 to 2%, weight content are less than or equal to 100ppm's Cycloalkane and weight content are the aromatic compounds less than or equal to 100ppm.

The hydrocarbon ils implemented in gelatine composition of the invention further preferably has the sulphur compound of extremely low weight content, leads to Often less than or it is equal to 5ppm, preferably lower than or equal to 3ppm, more preferably less than or equal to 0.5ppm, level is too low to make It is detected with conventional low content sulphur content analyzer.

The hydrocarbon ils implemented in gelatine composition of the invention is greater than according to 2719 standard of EN ISO even more preferably from having Or the flash-point equal to 110 DEG C, preferably greater than or equal to 120 DEG C and more preferably equal to or greater than 140 DEG C.Usually above 110 DEG C High-flash can especially be overcome in storage and transportational process and avoiding hydrocarbon ils too sensitive combustibility on the one hand Safety problem.

Hydrocarbon ils is even more preferably from the vapour pressure having at 20 DEG C less than or equal to 0.01kPa.

According to one embodiment, the hydrocarbon ils implemented in gelatine composition of the invention still more preferably has basis Flash-point of the standard EN ISO 2719 more than or equal to 110 DEG C and 20 DEG C of vapour pressures less than or equal to 0.01kPa.Preferably, hydrocarbon The flash-point of oil is greater than or equal to 120 DEG C, and 20 DEG C of vapour pressures are less than or equal to 0.01kPa.And it is highly preferred that its flash-point is big In or be equal to 130 DEG C, and 20 DEG C of vapour pressures are less than or equal to 0.01kPa.

The hydrocarbon ils implemented in gelatine composition of the invention have can overcome inflammability, smell and volatility problem Boiling temperature, flash-point and vapour pressure.

In addition, 40 DEG C of kinematic viscosity of the hydrocarbon ils of gelatine composition of the invention are less than according to standard EN ISO 3104 Or it is equal to 5cSt, preferably lower than or equal to 4cSt, and more preferably less than or equal to 3cSt.

The preparation method of hydrocarbon ils

The composition of this hydrocarbon ils can obtain in the following manner.Hydrocarbon ils of the invention is the hydrocarbon from biomass conversion Fraction.

Term " converting from biomass " refers to the hydrocarbon-fraction generated by biological source raw material.

Preferably, the hydrocarbon-fraction of biological source is by including that the method for hydrogenation deoxidation (HDO) and isomerization (ISO) step obtains .The step of hydrogenation deoxidation (HDO), makes the STRUCTURE DECOMPOSITION of biological ester or triglyceride content, to eliminate the phosphorus of oxidation With sulphur compound and make alkene key hydrogenate.Then the product isomerization that will be reacted from hydrogenation deoxidation.Fractionating step preferably exists It is carried out after hydrogenation deoxidation and isomerization steps.Advantageously, purpose fraction is then subjected to the step of then hydrotreating is distilled, To obtain the specification of the required hydrocarbon ils of the present invention.

The HDO/ISO method is to not adding in the group being made of vegetable oil, animal tallow, fish oil and its mixture Work biology, which feeds (also referred to as biomass or biological source raw material), to be implemented.Suitable biological source raw material is such as rapeseed oil, mustard Caul-fat, tall oil, sunflower oil, soybean oil, hemp-seed oil, olive oil, linseed oil, mustard oil, palm oil, peanut oil, castor Sesame oil, coconut oil, the animal fat such as dietary fat of tallow, recycling, genetic engineering raw material and by algae and bacterium etc. The biological raw material that microorganism generates.Condensation product, ester or other derivatives obtained in the biological raw material are also used as raw material.

Preferably, biological source raw material is ester or triglyceride derivatives.The material is first subjected to hydrogenation deoxidation (HDO) Step, to decompose the structure of ester or triglyceride component and eliminate the p and s chemical combination aoxidized while the hydrogenation of alkene key Object.It is the isomerization of thus obtained product after hydrogenation deoxidation (HDO) step of biological source raw material, this makes hydrocarbon chain point Branch, and improve the property of isoparaffin under low temperature.

In HDO step, hydrogen and biological source raw material pass through catalytic hydrodeoxygenation bed simultaneously or countercurrently.In HDO step In, pressure and temperature is respectively 20 to 150 bars and 200 DEG C to 500 DEG C.It is de- using conventional and known plus hydrogen in this step VPO catalysts.It is optionally possible to pre-hydrogenation be carried out to biological source raw material in a mild condition, to prevent before HDO step The secondary response of double bond.After hydrodeoxygenation step, self-reacting product carries out isomerization (ISO) step in the future, wherein making Hydrogen and product and optional normal paraffin hydrocarbons mixture pass through catalytic hydrodeoxygenation bed simultaneously or countercurrently.In ISO step, pressure It is respectively 20 to 150 bars and 200 DEG C to 500 DEG C with temperature.In this step using conventional and known isomerization catalyst.

It can also implement other householder methods (such as intermediate mixture, trapping or other such methods).

Product from HDO/ISO step can be optionally fractionated to obtain interested fraction.

Various HDO/ISO methods are described in the literature.WO2014/033762 application describes a kind of method, packet Include the isomerization steps that pre-hydrogenation step, hydrodeoxygenation step (HDO) and adverse current carry out.Patent application EP1728844 is described A method of hydrocarbon compound is produced by the compound mixture in plant and animal source.This method includes carrying out in advance to mixture The step of processing, can remove pollutant such as alkali metal salt in this way, then carry out hydrogenation deoxidation (HDO) step and isomerization step Suddenly.Patent application EP2084245 describe it is a kind of by by the hydrogenation mixture deoxidation containing the biological source of aliphatic ester, so The method that may be used as diesel oil or the hydrocarbon mixture for Dresel fuel compositions is produced with specific catalyst hydrogenation isomerization afterwards, The aliphatic ester is optionally the mixture with free fatty acid, such as vegetable oil, such as sunflower seed oil, rapeseed oil, mustard Oil, palm oil or pine tar.The product that patent application EP2368967 describes such method and obtained by this method. WO2016/185046 application describes a kind of method for obtaining the hydrocarbon ils that the present invention uses, and wherein the hydrocarbon ils is by right Deoxidation and the isomerization charging of biological source carry out catalytic hydrogenation at 80 DEG C to 180 DEG C of temperature and 50 to 160 bars of pressure Method obtain.

Advantageously, biological source raw material includes the sulphur for being less than 15ppm according to standard EN ISO 20846, preferably smaller than 8ppm, preferably smaller than 5ppm, more preferably less than 1ppm.It is desirable that charging does not include any sulphur as biological source raw material.

Before hydrotreating step, prefractionation step can be carried out.Relatively narrow fraction in the input of hydrogenation unit makes Narrow fraction can be obtained at the output of unit by obtaining.In fact, the boiling point of the fraction of prefractionation is 220 DEG C to 330 DEG C, and without The boiling point of the fraction of prefractionation is usually 150 DEG C to 360 DEG C.

Then by from HDO/ISO method deoxidation and isomerization charging hydrogenate.

Hydrogen used in hydrogenation unit is usually High Purity hydrogen.Term " High Purity " refers to that purity is greater than 99% Hydrogen, but the hydrogen of other grades also can be used.

Step of hydrogenation is carried out by means of catalyst.Typical hydrogenation catalyst can be for agglomerate or through loading, and can be with Including following metal: nickel, platinum, palladium, rhenium, rhodium, nickel tungstate, nickel-molybdenum, molybdenum, cobalt-molybdenum.Carrier can be silica, aluminium oxide, Silica-alumina or zeolite.

Preferred catalyst is that have Ni-based catalyst on the alumina support, and specific surface area is 100 to 200m²/g Catalyst or Ni-based agglomerate catalyst.Hydrogenation conditions are generally as follows:

Pressure: 50 to 160 bars, preferably 80 to 150 bars, more preferable 90 to 120 bars；

Temperature: 80 DEG C to 180 DEG C, preferably 120 DEG C to 160 DEG C, more preferable 150 DEG C to 160 DEG C；

Liquid hourly space velocity (LHSV) (LHSV): 0.2 to 5hr^-1, preferably 0.4 to 3hr^-1, more preferable 0.5 to 0.8hr^-1；

Hydrogen treat rate: adapting to above-mentioned condition, and charging to be processed per ton can reach 200Nm³。

Temperature in reactor is usually 150 DEG C to 160 DEG C, and pressure is about 100 bars, and when air speed be about 0.6hr^-1, Processing speed is depending on the quality of charging to be processed and the parameter of the first hydrogenation reactor.

Hydrogenation can carry out in one or several concatenated reactors.Reactor may include one or several catalytic beds. Catalytic bed is usually fixed formula catalytic bed.

Method for hydrogenation preferably includes two or three reactors, preferably three reactors, and more preferably connects at three Reactor in carry out.

First reactor can trap sulphur compound and carry out essentially all unsaturated compound and at most about 90% The hydrogenation of aromatic compounds.Product from first reactor is substantially free of sulphur compound.It is in second stage, i.e., anti-second It answers in device, the hydrogenation of aromatics continues, and thus at most 99% aromatics are hydrogenated.

Phase III in third reactor is refining stage, can be obtained less than or equal to 500ppm, preferably smaller than Or the aromatics equal to 300ppm, preferably lower than or equal to 100ppm, more preferably less than 50ppm, desirably less than or equal to 20ppm Object content, in addition it is with the product of higher boiling (being greater than 300 DEG C) and such.

The reactor with two or three above catalytic beds can be used.Catalyst can be in each reactor with not Same or essentially identical amount exists；For three reactors, amount by weight can be, for example, 0.05-0.5/0.10-0.70/ 0.25-0.85, preferably 0.07-0.25/0.15-0.35/0.4-0.78, more preferably 0.10-0.20/0.20-0.32/ 0.48-0.70。

Also one or two hydrogenation reactor can be used rather than three.

First reactor can also be made of the double-reactor alternately implemented.This operable method is particular enable to promote The loading of catalyst and unloading: when first reactor includes the catalyst being saturated first, (essentially all sulphur, which is all captured in, is urged In agent and/or in), must often replace.

Also the single reactor for being equipped with two or three above catalytic beds can be used.

May must in the circulatory system or between reactor insertion case is quenched, with cooling from a reactor to another Reactor or from a catalytic bed to the effluent of another catalytic bed, to control the temperature and Heat And Water Balance of each reaction. According to a preferred embodiment, there is no cooling or intermediate equipment is quenched.

According to one embodiment, the product from this method and/or isolated gas are at least partly in hydrogenation It is recycled in the feed system of device.This dilution helps for the heat release of reaction to be maintained in controlled range, especially the One stage.In addition, recycling can carry out heat exchange before reactions, and it can also preferably control temperature.

The effluent of hydrogenation unit mainly includes hydrogenated products and hydrogen.Flash separator is used to effluent being separated into gas phase (mainly remaining hydrogen), and it is separated into liquid phase (hydrocarbon-fraction mainly hydrogenated).This method can be flashed by using three Separator carries out, and described three flash separators one is in high pressure, and one is in middle pressure, and one is in very close atmosphere The low pressure of pressure.

The Gaseous Hydrogen of flash separator collected overhead can be in the feed system of hydrogenation unit or between reactor Hydrogenation unit in different level recycling.

According to one embodiment, final product separates under atmospheric pressure.Then it is sent directly into vacuum topping unit. Preferably, fractionation will carry out under 10 to 50 millibars of pressure, and more preferably carry out under about 30 millibars.

Fractionation can by can remove from fractionating column various hydrocarbon fluids simultaneously and in a manner of it can make a reservation for its boiling temperature into Row.

By adjusting the initial and final boiling point of charging, hydrogenation reactor, separator and fractionation unit can thus directly Connection, without using pans.The thermal that this combination of hydrogenation and fractionation can be optimized, while reducing device number It measures and energy saving.

Advantageously, the hydrocarbon ils implemented in gelatine composition of the invention is the boiling range measured according to standard ASTM D86 DR (by DEG C in terms of) be 230 DEG C to 340 DEG C, preferably 235 DEG C to 330 DEG C, more preferably 240 DEG C to 325 DEG C of hydrocarbon-fractions.It is preferred that The difference of ground, initial boiling point and final boiling point is less than or equal to 80 DEG C, preferably less or equal to 70 DEG C, even more preferably less than or waits In 60 DEG C, and it is advantageously 40 DEG C to 50 DEG C.Hydrocarbon ils may include the one or several kinds of fractions of boiling range within the above range.

Advantageously, the hydrocarbon ils implemented in gelatine composition of the invention is fully saturated.Preferably, the group of hydrocarbon ils It is selected from the isoparaffin comprising 12 to 30 carbon atoms, preferably 13 to 19 carbon atoms and more preferable 14 to 18 carbon atoms.

It is the isohexadecane less than or equal to 50% that gelatine composition of the invention, which advantageously comprises weight content,.

It is desirable that the hydrocarbon ils of gelatine composition of the invention carrys out the processing of biological origin raw material.Term " biological carbon " It indicates that carbon is natural, and comes from biomaterial, as described below.The content of biological carbon and the content of biomaterial are Indicate the expression of identical value.The material or biomaterial of renewable source are a kind of organic materials, and wherein carbon comes from by photosynthetic Act on the CO recently fixed (in terms of human scale) from atmosphere₂.The isotope ratio of biomaterial (carbon of natural origin 100%)¹⁴C/¹²C is greater than 10^-12, usually about 1.2 × 10^-12, and the isotope ratio of fossil material is zero.In fact, isotope¹⁴C be It is formed in atmosphere, is then integrated by photosynthesis, decades are at most according to time scale.¹⁴The half-life period of C is 5, 730 years.Therefore, photosynthetic substance, i.e., plant in general, isotope are come from¹⁴C must have maximum level.

According to standard ASTM D 6866-12, method B (ASTM D 6866-06) and (the ASTM D of ASTM D 7026 7026-04) determine the content of biomaterial or biological carbon.The biomaterial content of the hydrocarbon ils of gelatine composition of the invention is At least 90%.The higher the content the more advantageous, and particularly greater than or equal to 95%, preferably larger or equal than 98% and advantageously Equal to 100%.

Other than the biomaterial of special high-content, the hydrocarbon ils of gelatine composition of the invention also has particularly preferred Biodegradability.The biodegrade of organic chemistry product refers to the metabolic activity due to microorganism and reduces answering for compound Polygamy.Under aerobic conditions, organic substance is converted carbon dioxide, water and biomass by microorganism.OECD306 method is for commenting Estimate the biodegradability of individual substance in seawater.According to this method, 28 days biodegradabilities of hydrocarbon ils are to be at least 60%, More preferably at least 70%, more preferably at least 75%, and it is advantageously at least 80%.

Polymer and non-polymeric gelling agent

Gelatine composition of the invention may include one or several kinds of gel polymers or non-polymer gelling agent type Gelling agent, therefore hydrocarbon ils can be gelled.

According to the present invention, term " gel polymer " must be understood as include can be as comprising hydrocarbon ils defined in the present invention Non-polar oil form the polymer of gelatine composition or gel.

According to the present invention, term " non-polymer gelling agent " must be understood as including the compound different from polymer, should Compound can form gelatine composition or gel as the non-polar oil comprising hydrocarbon ils defined in the present invention.

One or more gelling agents can account for the 0.5 weight % to 50 weight %, preferably 1 weight of gelatine composition total weight Measure % to 40 weight %, more preferable 5 weight % to 30 weight %.

According to embodiment of the present invention, the gel polymer implemented in gelatine composition be selected from homopolymer and Copolymer, the homopolymer and copolymer include to be selected from isoprene, butadiene, styrene and (methyl) acrylate extremely A kind of few monomer and its mixture.

According to the present invention, term " homopolymer " must be understood as including the polymer obtained by single and identical monomer.

According to the present invention, term " copolymer " must be understood as including the polymer obtained by least two different monomers.

According to the present invention, term is " comprising being selected from isoprene, butadiene, styrene and (methyl) acrylate extremely The homopolymer of few a kind of monomer " must be understood as including polyisoprene, polybutadiene, polystyrene and (methyl) acrylate Homopolymer.

According to the present invention, term is " comprising being selected from isoprene, butadiene, styrene and (methyl) acrylate extremely The copolymer of few a kind of monomer " must be understood as including by selected from isoprene, butadiene, styrene and (methyl) acrylate At least one of monomer obtain copolymer.The copolymer implemented in gelatine composition of the invention may include other The monomer of type.

According to embodiment of the present invention, the polymer implemented in gelatine composition can be for example with molten The form of liquid, water slurry or dispersion.

According to one embodiment, polymer is selected from star polymer, diblock copolymer, triblock copolymer, how embedding Section copolymer, comb polymer, radial polymers and the combination of the latter.

According to one embodiment, gel polymer includes at least one styrene monomer.According to one embodiment, phase For the total weight of polymer, the weight content of the styrene units for the polymer that the present invention is implemented is 5% to 50%, more preferably 10% to 40%.

According to one embodiment, gel polymer is selected from styrene monomer and is selected from ethylene, propylene, butadiene, isoamyl One of diene or several monomeric.

According to embodiment of the present invention, polymer is selected from styrene block copolymer, more preferably includes at least A kind of elastomeric blocks.Preferably, styrene block copolymer is selected from by SIS (polystyrene-polyisoprene-polyphenyl second Alkene), SIBS (polystyrene-polyisoprene-polybutadienes-polystyrene), SBS (polystyrene-polybutadiene-polyphenyl second Alkene), SEBS (polystyrene-poly (ethylene butene)-polystyrene) and SEPS (polystyrene-poly (ethylene, propylene)-polyphenyl second Alkene) composition group.Such polymer can for example pass through commodityG1702(SEP)、G1650(SEBS)、D1101 (mixture of SEBS and SEP) is obtained from Kraton company.

According to embodiment of the present invention, polymer is selected from the homopolymer and copolymer obtained by isoprene.It is poly- Polyisoprene can be for example selected from by closing object.Such polymer can for example pass through commodityG 1750 (EP) orIR is obtained from Craton company.

Particular implementation according to the present invention, polymer are selected from styrene/butadiene copolymers, styrene/isoamyl two Alkene copolymer, hydrogenated styrene/butadiene copolymer, hydrogenated styrene/isoprene copolymer, hydrogenated polyisoprene crosslinking Polymer, polyisoprene homopolymer, hydrogenated styrene thermoplastic homopolymer, liquid rubber and its mixture.

Polymer can account for the 0.5 weight % to 50 weight % of gelatine composition total weight, preferably 1 weight % to 40 weights Measure %, more preferable 5 weight % to 30 weight %.

Another embodiment according to the present invention, gelling agent are non-polymer gelling agents, be preferably selected from mineral filler, Wax, ammonium salt and metal salt are more preferably selected from mineral filler, wax and metal salt.

In the mineral filler that can be used, it can be mentioned that clay, montmorillonite, silicate such as alumina silicate, silica and Hectorite.The surface of mineral filler can be modified or not modified, and in the case where surface is modified, biology or non-can be used It is modified that the grafting of biological source carries out surface.

In the wax (non-polymer) that can be used, it can be mentioned that native paraffin, such as vegetable wax, animal wax, ceresine and mine Wax.Vegetable wax can be selected from shea butter, camellia, sunflower, small candle tree, Brazil wax.Animal wax can be selected from beeswax.

In metal salt, it can be mentioned that zinc stearate.

According to embodiment of the present invention, gelling agent is non-polymer gelling agent, is selected from:

Mineral filler is selected from clay, montmorillonite, alumina silicate, silica and hectorite,

Wax is selected from vegetable wax, animal wax, ceresine and mineral tallow,

Metal salt.

Non-polymer gelling agent can account for the 0.5 weight % to 50 weight % of gelatine composition total weight, preferably 1 weight % To 40 weight %, more preferable 5 weight % to 30 weight %.

According to embodiment of the present invention, gelatine composition includes at least one polymer defined in the present invention Gelling agent and at least one non-polymer gelling agent.

Gelatine composition of the invention is more preferably non-aqueous.

According to one embodiment, gelatine composition is more preferably substantially free of antioxidant, in other words, gelatine group It closes object and preferably comprises the antioxidant for being less than 150ppm by weight, even more preferably comprising anti-less than 100ppm by weight Oxidant is even more preferably entirely free of antioxidant, and wherein antioxidant can be selected from hindered phenol type compound, such as BHT (2,6 di tert butyl 4 methyl phenol).

According to embodiment of the present invention, gelatine composition is by one or several kinds of hydrocarbon ils defined above and one kind Or several gelling agent compositions defined above.

According to embodiment of the present invention, gelatine composition is by least one hydrocarbon ils defined above and at least one Kind polymer composition defined above.

The present invention relates to gelatine compositions defined above, it is highly preferred that not including that group consisting of closes object:

Mixture, 100 mass % include:

I) 3.7% linear paraffinic hydrocarbons comprising 15 to 19 carbon atoms,

Ii) 96% isoparaffin comprising 15 to 19 carbon atoms,

Iii) 0.3% cycloalkane comprising 15 to 19 carbon atoms,

And hydroxyethylacrylate copolymer/acryloyl dimethyl tauric acid acrylate copolymer (INCI title),

And mixture/copolymer mass ratio is 15/2；

And/or the composition being made up of:

Mixture M '₁, 100 mass % include:

I) 3.7% linear paraffinic hydrocarbons comprising 15 to 19 carbon atoms,

Ii) 96% isoparaffin comprising 15 to 19 carbon atoms,

Iii) 0.3% cycloalkane comprising 15 to 19 carbon atoms,

Mixture M '₂, 100 mass % include:

I) linear paraffinic hydrocarbons comprising 15 to 19 carbon atoms of 13.20 weight %,

Ii) the isoparaffin comprising 15 to 19 carbon atoms of 55.00 weight %,

Iii) the cycloalkane comprising 15 to 19 carbon atoms of 31.80 weight %,

And mixture M '₁/ mixture M '₂The mass ratio of/copolymer is 12/3/2.

Really it is noted that hydroxyethyl acrylate copolymer/acryloyl dimethyl tauric acid acrylic ester copolymer Object cannot form gel with non-polar oil.Such polymer may form gel with water phase.

The preparation of gelatine composition

Gelled composition can be prepared according to any method well known to those skilled in the art, to prepare gel.For example, Gelatine composition of the invention can be prepared by method comprising the following steps:

Hydrocarbon ils and gelling agent, particularly gel polymer are mixed；

The mixture of hydrocarbon ils and gelling agent, particularly gel polymer is heated, is more preferably heated to 40 DEG C to 180 DEG C Or 60 DEG C to 150 DEG C of temperature；

The mixture of agitating and heating, until obtaining homogeneous mixture；

Homogeneous mixture is usually cooled to environment temperature (about 25 DEG C).

According to another embodiment, hydrocarbon ils heats in advance before mixing with gelling agent, particularly gel polymer.

Additive

Gelatine composition of the invention can also with usually in the field considered, especially beauty, skin care or Any adjuvant used in pharmaceutical field or additive mixing.Certainly, those skilled in the art will ensure that selection present invention combination The favorable property that the mode of any one or more of additive makes gelatine composition of the invention intrinsic in object will not or base It will not change because of the addition of consideration in sheet.(according to the water solubility or rouge of these auxiliary agents in the conventional additives that may include Dissolubility), it is particularly possible to refer to anionic lathering surfactant agent (such as sodium laureth sulfate, alkyl phosphoric acid sodium, tridecyl sulphur Sour sodium), amphoteric surfactant (such as alkyl betaine, cocounut oil both sexes diethyl acid disodium) or HLB be greater than 10 nonionic table Face activating agent (such as POE/PPG/POE, alkyl poly glucoside, 3 hydroxylauric base ether of polyglycereol)；Preservative, as benzene pricks chlorine Ammonium；Chelating agent (EDTA)；Antioxidant；Flavouring agent；Dyestuff, such as soluble dye, pigment and mother-of-pearl；Dumb light, tensioning, increasing White or exfoliating filler；Sun-proof filler；With the beauty or skin care activity for improving hydrophily or lipohilic skin cosmetic properties at Point and reagent；Electrolyte.The amount of these various auxiliary agents be conventional use of amount, for example, composition total weight in consideration field 0.01% to 20%.As the active constituent in gelatine composition for use in the present invention, can be mentioned that it is for example water-soluble or Liposoluble vitamin, such as vitamin A (retinol or beta carotene), vitamin E (tocopherol), vitamin C (Vitamin C Acid), vitamin B5 (panthenol), vitamin B3 (niacinamide), these vitamins derivative (especially esters) and its mixture； Preservative；Active antibacterial ingredient, such as 2,4,4'- tri- chloro- 2'- dihydroxy diphenyl ethers (or triclosan), 3,4,4'- trichlorine carbanilides Aniline (or triclocarban)；Antiseborrheic；Antibacterial agent, such as benzoyl peroxide, niacin (nicotinic acid)；Anoretic, example Such as caffeine；Fluorescent whitening agent, and any active constituent and its mixture for composition final purpose.

Beauty, skin care or pharmaceutical composition

The present invention also aims to beauty, skin care or pharmaceutical composition, it includes gelatine composition of the invention and:

At least one fatty material, it is excellent selected from vegetable oil, vegetable butter, fatty alcohol and ether, oily ester, alkane and silicone oil Choosing is selected from oily ester,

And/or

At least one additive is selected from above-mentioned additive, is preferably selected from anionic lathering surfactant agent (such as the moon Osmanthus base ether sodium sulfate, alkyl phosphoric acid sodium, tridecyl sulfate), amphoteric surfactant (such as alkyl betaine, cocounut oil two Property diethyl acid disodium) or nonionic surfactant of the HLB greater than 10 it is (such as POE/PPG/POE, alkyl poly glucoside, poly- - 3 hydroxylauric base ether of glycerol).

Fatty material is preferably selected from low polar fatty material.

The example of vegetable oil especially wheat embryo, sunflower, grape pip, sesame, corn, apricot, castor-oil plant, cream wooden fruit, crocodile Pears, olive, soybean oil, dessert almond, palm, rapeseed, cotton, fibert, Queensland nut, jojoba oil, clover, opium poppy, pumpkin, Sesame, pumpkin, rapeseed, blackcurrant, cordate telosma, millet, barley, quinoa, rye, kardiseed, candle fruit, passionflower, fructus rosae Or camellia oil.

Vegetable butter is and vegetable oil fatty material with the same characteristics.Difference between the two is rouge in environment temperature It is down in solid form.In addition, with vegetable oil on the contrary, the raw material (pulp, seed or almond) for therefrom extracting rouge extracts after grinding It is heated after fat.As vegetable oil, rouge can be refined to provide better anti-corrosive properties, neutralizer flavor, improve color and thick Degree.The elasticity that can improve skin rich in antioxidant and nourishing beauty characteristic of vegetable butter, by leaving protective film on epidermis Extraneous infringement is protected the skin from, to reduce dehydration by regenerating the natural water adipose membrane of skin, repair and releive.It plants The wooden fruit rouge of the example of object rouge especially cream, cocoa butter, mango butter, sal tree fruit rouge or olive rouge.

Fatty alcohol and ether are the wax-like long-chain substances of fat, with apparent characteristic, especially film forming, moisturizing, moisturizing, soft Soft protection feature.It serves as moisturizing oil and emulsifier.The example of fatty alcohol or ether is: cetanol, stearyl alcohol, myristyl alcohol, Laruyl alcohol, docosyl alcohol, cetostearyl alcohol, two caprylyl ethers, stearyl ether or octyldodecanol (by its INCI name identification).

Oily ester or esterised oil are that (fatty alcohol is more for fatty acid (long chain acid, such as stearic acid, oleic acid, palmitinic acid) and alcohol First alcohol, such as glycerol) between the product that reacts.These oil may include the substance from petrochemicals, as palmitinic acid is different The case where propyl ester, is such.The example of oily ester is Miglyol 812N, caprylic capric cocounut oil ester, oleyl erucate oleyl Ester, linoleic acid oil alkenyl esters, decyl oleate or PPG-3 myristic acid benzylic ether (by its INCI name identification).

Term " silicone oil or polysiloxanes " refers to comprising at least one silicon atom, especially at least Si-O group Oil.It, can be with specifically mentioned phenyl propyl dimethyl silane oxygroup esters of silicon acis, penta silicon of dimethyl silicone polymer or ring as silicone oil Oxygen alkane (by its INCI name identification).

The beauty, skin care or pharmaceutical composition include physiologically acceptable medium, that is, it does not have any harmful pair Effect especially will not generate any unacceptable rubescent, inflammation, tight or tingling sensation to user.In addition to above-mentioned gelling Change except composition, which optionally includes water and/or at least one oil as fatty material.

According to one embodiment, the content of the above-mentioned gelatine composition of beauty, skin care or pharmaceutical composition relative to The total weight of composition is 0.5 weight % to 80 weight %, and preferably 1 weight % to 50 weight % is advantageously 5 weight % extremely 30 weight %.

Preferably, when selecting fatty material from vegetable oil, fatty material will preferably comprise from beauty, skin care or pharmaceutical composition The weight of object less than 50 weight %, even more preferably less than 30 weight %.

Preferably, when fatty material is selected from silicone oil or polysiloxanes, fatty material will preferably comprise from beauty, skin care or drug The weight of composition less than 40 weight %, even more preferably less than 30 weight %.

Therefore, according to the additive being optionally introduced and/or according to the water phase being optionally introduced, beauty of the invention, skin care or Pharmaceutical composition can be anhydrous composition, lotion such as water-in-oil emulsion (W/O), oil-in-water emulsion (O/W) or multiple emulsion (especially W/O/W or O/W/O), nanoemulsions or dispersion.

When composition is emulsion oil-in-water, it is preferable that the present invention is not related to oil-in-water (E) type cream of local use Liquid, 100% mass includes:

The cosmetically acceptable water phase (A) of -50 weight % to 90 weight %,

The fatty phase (F) of -10 weight % to 50 weight %, 100% mass includes:

- 10 weight % to 50 weight %, more particularly 15 weight % are to the linear or branch of 40 weight %, ring-type or acyclic The mixture (M1) of shape saturated hydrocarbons, wherein at least 95 weight % include 15 to 19 carbon atoms；

At least one oil-in-water type surfactant of -0.5 weight % to 15 weight %,

The protective agent of at least one confrontation solar ultraviolet radiation of -5 weight % to 30 weight %,

At least one oil and/or at least one wax of -0 to 80 weight %, it is thus understood that this oil and/or this wax are discontented The definition of sufficient mixture (M1)；

When composition is emulsion oil-in-water, it is preferable that the present invention is not related to oil-in-water (E) type lotion, 100% matter Amount includes:

The cosmetically acceptable water phase (A) of -40 weight % to 90 weight %, 100% mass include 1 weight % to 30 The glycerol of weight %, and

The fatty phase (F) of -10 weight % to 60 weight %, 100% mass include the linear of 1 weight % to 25 weight % Or branch, ring-type or non-annularity saturated hydrocarbons mixture (M1) and 0.5% to 15% at least one oil-in-water type surface-active Agent, at least 95 weight % in the mixture (M1) include 15 to 19 carbon atoms.

Beauty, skin care or pharmaceutical composition of the invention may be constructed for example for removing ornaments and formal dress or the group of cleaning skin, lip Object is closed, the composition of massaging skin is used for after sunscreen composition (ultraviolet protection) or solarization, take a shower health care composite cream, hidroschesis Agent composition, mask composition, maintenance composite cream, face and hand wash by rubbing with the hands and/or exfoliating composition (when containing beveling When matter particle), color make-up composition and is had a shave composite cream, flavor enhancing composition and wiping composition at Shave composition.

The favorable characteristics of composition of the invention are have and be greater than or equal to 4 weeks, advantageously greater than or equal to 6 weeks Lasting stability, wherein stability is assessed after not stirring storage under environment temperature (40 DEG C and 50 DEG C), and is corresponded to The visual assessment and Olfactive evaluation of color and appearance and/or viscosity measurement.

The purposes of gelatine composition

The present invention also aims to compositions defined above in skin, lip or adnexa (including nail, scalp and hair Hair) on local application beauty, skin care or pharmaceutical use.

The present invention also aims to beauty defined above, skin care or pharmaceutical compositions as skin nursing products (essence Magnificent liquid, creams, ointment etc.), as health product, as product after sun-screening agent/solarization, make as color make-up product as cleansing product For perfume products, as antiperspirant products, beauty, skin care or pharmacy as lip care product (such as lip gloss or lip gloss) are used On the way.

Gelatine composition of the invention can be preferably used as active constituent to improve skin appearance and/or enhancing hair And/or delaying senility and/or postpone wrinkle appearance and/or reduce wrinkle and/or tightening skin.Particularly, human hair of the present invention Existing gelled composition has antioxidation and anti-radical action.

Gelled composition of the invention can be used as drug preferably as active constituent.

According to an aspect of the present invention, gelatine composition may be used as antioxidant and/or antifree radical agent and/or Anti-inflammatory agent and/or anti-apoptotic and/or antibacterium and/or antifungal agent.

The present invention also aims to the beauty, skin care or method of pharmacy for treating skin, this method includes at least one It is a the step of applying composition defined above on skin, lip and/or adnexa.

Composition of the invention can also be used to prepare cosmetic composition, skin care compositions or pharmaceutical composition, and it includes remove Other components or other phases except described above.This especially can be preparation nursing, health or cosmetic composition.

Cosmetic treatment method

Finally, this method includes at least one following steps the invention further relates to a kind of cosmetic treatment method: skin, (preferably passing through smearing) composition of the invention is applied on lip or adnexa.

Embodiment

In the rest part of this specification, embodiment is given for information of the invention, under any circumstance All it is not intended to be limited to the scope of the present invention.

Gelatine composition

A kind of gelled composition, it includes the styrene-baseds and ethylene/propylene of the hydrocarbon ils of 90 weight % and 10 weight % The linear diblock copolymer of alkene, wherein the content of polystyrene is 28 weight % of polymer weight.It is described according to the present invention Method prepare gelatine composition.

Table 1 summarizes the physicochemical properties of hydrocarbon ils.

Table 1: the physicochemical properties of hydrocarbon ils

Characteristic	Hydrocarbon ils
		Aromatics (ppm)	<20
Sulphur (ppm)	0.11
		Isoparaffin % (w/w)	96.2
Normal paraffin hydrocarbons % (w/w)	3.8
		Cycloalkane % (w/w)	0
C13 (different)	0
		C14 (different)	0
C15 (different)	0
		C16 (different)	1.58
C17 (different)	14.17
		C18 (different)	79.69
C19 (different)	0.12
		C20 (different)	0.38
C27 (different)	0.29
		The amount (%) of bioresource carbon	>98
Initial boiling point (DEG C)	293.6
		5% boiling point (DEG C)	296.7
50% boiling point (DEG C)	298.5
		95% boiling point (DEG C)	305.3
Final boiling point (DEG C)	324.1
		OECD biodegradability (28 days) (%)	83
20 DEG C of refractive index	1.4394
		15 DEG C of density (kg/m3)	787.2
Flash-point (DEG C)	149
		40 DEG C of kinematic viscosity (cSt)	3.87
20 DEG C of vapour pressures (kPa)	<0.01
		Aniline point (DEG C)	93.2

Above-mentioned characteristic is measured using following standard and method:

Flash-point: EN ISO 2719

- 15 DEG C of density: EN ISO 1185

- 40 DEG C of viscosity: EN ISO 3104

Aniline point: EN ISO 2977

Boiling point: ASTM D86

Biodegradability: OECD method 306

- 20 DEG C of refractive index: ASTM D 1218

Vapour pressure: it is calculated according to method well known to those skilled in the art

The evaluation of the compatibility of gelatine composition and fatty material

The fatty material of test are as follows:

Vegetable oil: white awns flower seed oil (according to INCI title), 20 DEG C of density are 0.91, and relative to vegetable oil Total weight, it includes:

The gadoleic acid (C20:1) of 0 58.0 weight % to 64.0 weight %

The erucic acid (C22:1d13) of 0 10.0 weight % to 14.0 weight %

The docosenoic acid (C22:1d5) of 0 3.0 weight % to 6.0 weight %

Two dodecadienoic acids (C22:2) of 0 15.0 weight % to 21.0 weight %

Oily ester: isononyl isononanoate (according to INCI title), it is commercially available.

Silicone oil: cyclopentasiloxane (according to INCI title), it is commercially available.

The operation includes by increase weight percent: 10%, 25%, 50%, 75% and 90% by rouge to be tested Fat substance is added in gelatine composition the compatibility for observing gelatine composition and fatty material.These operations are continuous It carries out.Mixture is observed between each addition.Addition is carried out in same container.

Experiment starts to carry out and terminate with 450g based on 45g gelatine composition.In fact, addition is same based on presence What the 45g in beaker was carried out:

- 10%: addition 5g fatty material to be tested.

- 25%: adding 10g fatty material to be tested (15*100/60=25) in the mixture previously obtained.

- 50%: 30g fatty material to be tested is added in the mixture previously obtained.

- 75%: 90g fatty material to be tested is added in the mixture previously obtained.

- 90%: 270g fatty material to be tested is added in the mixture previously obtained.

Final mixture is stored in glass jar, and is observed in D+1.When being visually observed precipitating, claim the mixture Immiscible.

Therefore it observes:

In the presence of vegetable oil is with the at most amount of 50 weight %, gelatine composition of the invention can be miscible with vegetable oil.

In the presence of oily ester is with the at most amount of 90 weight %, gelatine composition of the invention can be miscible with oily ester.

In the presence of silicone oil is with the at most amount of 25 weight %, gelatine composition of the invention can be miscible with silicone oil.

The evaluation of the compatibility of gelatine composition and emulsifier

The preparation of lotion

Test following oil-in-water (O/W) emulsifier:

Anion emulsifier: Sensanov(can obtain from Seppic) corresponds to products C 20-22 alkyl acid phosphate Ester and C20-22 alcohol (according to INCI title).

- two kinds of nonionic emulsifier:

○68 (can be obtained from Seppic), correspond to cetostearyl alcohol (and) cetearyl alcohol glucoside (according to INCI title).

○165 (can be obtained from Seppic), correspond to product PEG-100 stearate (and) glyceryl stearate Acid esters (according to INCI title).

Cationic emulsifier:Behenyl TMS (can be bought) from Croda, correspond to product cetearyl alcohol Alcohol, three ammonium of methylsulfuric acid docosyl alcohol (according to INCI title).

It is also tested for Water-In-Oil (W/O) emulsifier:

Nonionic emulsifier:EM180 (can be obtained) from Evonik, correspond to product cetyl PEG/PPG-10/ 1 dimethicone (according to INCI title).

Lotion 1 to 5 is prepared using above-mentioned 5 kinds of emulsifiers.The following table 2 shows the composition of the lotion 1 to 5 of test.

Lotion (H/E) 1 to 4 is prepared according to following operation sequence:

Water is weighed, is stirred and heated to 50 DEG C.At 50 DEG C, glycerol and xanthan gum pre-composition are poured under fast stirring. It is kept stirring homogeneous until obtaining.Finally, continuing to be heated to 75 DEG C to 80 DEG C (depending on emulsifiers).

Fatty phase is weighed, is stirred and heated to 75 DEG C to 80 DEG C.

At 75 DEG C to 80 DEG C, fat is mutually gradually poured into water phase under fast stirring.Then it begins to cool.

At 72 DEG C to 75 DEG C, useType equipment stirs lotion 30 seconds at 9,500rpm.

It then proceedes to cool down.

At 50 DEG C, preservative is poured into lotion under stiring.

At 25 DEG C, measurement and adjusting pH value are (molten with 10% soda solution, or the citric acid of use 50% as needed Liquid) to required range 5.00 to 7.00.

Lotion (E/H) 5 is prepared according to following operation sequence:

Water and glycerol are weighed, stirring is placed.Salt is added, preservative is then added.

Emulsifier is weighed, stirring is placed.Ester is added thereto under stiring, followed by gelatine composition.

When two-phase homogeneous: water phase is slowly added dropwise in fatty phase.

When being added to the water phase of one third or more, can accelerate to add.

Table 2: the explanation of the lotion 1 to 5 of test (weight percent of the total weight relative to lotion is expressed)

(1) pH is adjusted using 10% soda solution

Each lotion is observed under the microscope

By observing each lotion under the microscope, the compatible of gelatine composition and emulsifier of the invention is visually evaluated Property.

The stability of viscosity at any time

The viscosity of lotion also use Brookfield RV DVII+PRO in advance between 24.5 DEG C and 25.5 DEG C it is permanent It is measured 1 minute in the 200g wide-mouth bottle of temperature.Particularly, assessment viscosity changes with time: in D0, D+1 (24 hours), 2 weeks, 4 Week and 8 weeks.Score "+" indicates satisfactory stability, and score " ++ " indicates extraordinary stability.

The stability of pH at any time

The also pH value determination within time of the D0 (initial) by 8 weeks.Score "+" indicates satisfactory stability (at any time Have downward trend with temperature), score " ++ " indicates good stability (being declined slightly trend with temperature), and score " +++ " indicates Extraordinary stability.

Centrifugal stability

Lotion be centrifuged within 1.5 hours with 4,000rpm in D+1 (24 hours).Score "+" indicates satisfactory steady It is qualitative, and a small amount of water is formd, score " ++ " indicates extraordinary stability, without any unstable.

The result of these tests is summarised in the following table 3.

Table 3: the properties evaluations of lotion 1 to 5

(1) since D+1

(2) it is not suitable for such lotion (E/H)

In a word, it may be noted that gelatine composition of the invention is compatible with different types of emulsifier.

The preparation of cosmetic formulation comprising gelatine composition

Face cream

Prepare the face cream with ingredient shown in the following table 4.The content of each ingredient is with the weight relative to creams composition total weight Measuring percentage indicates.For each ingredient of previously prepared gelatine composition, INCI title (EU) is given.

Table 4: the composition of face cream

The method for preparing face cream:

A) ingredient of A phase is put under stiring, is heated to 75 DEG C until obtaining homogeneous.

B) weigh water andBD.It is put into and begins to warm up under stiring.In 50 DEG C of introducing glycerol andT pre-composition.It is homogeneous until obtaining to continue stirring, while continuing to be heated to 75 DEG C.In 75 DEG C of introducing chlorine The sweet ether of benzene.Then it under 75 DEG C and 1200rpm, is prepared by the way that A phase (obtaining in step a) is poured into B phase (obtaining in step b) Lotion.It is begun to cool by being kept stirring speed.It is used at 72 DEG CWith 9,500rpm processing 30 seconds, then suitable Continue to cool down under degree stirring.

C) it is introduced at 50 DEG CThen it dispensesEMT10.It keeps under fast stirring Until obtaining uniform product.Then continue to cool down in the case where being slightly agitated for.

D) under environment temperature (23 DEG C), the component of D phase is added in succession.PH value determination, and if necessary with 10% Soviet Union It beats solution to be adjusted, to obtain pH as 5.50 to 6.00.

Skin-moisturizing, skin cream

Preparing has the skin-moisturizing, skin dew formed shown in the following table 5.The content of each ingredient is relative to creams composition gross weight The weight percent of amount indicates.For each ingredient of previously prepared gelatine composition, INCI title (EU) is given.

Table 5: the composition of milky lotion

The method for preparing milky lotion:

A) ingredient of A phase is put under stiring, is heated to 80 DEG C until obtaining homogeneous.

B) EDTA of B phase and water are put under stiring until obtaining homogeneously, while being heated to 50 DEG C.It is introduced at 50 DEG CWithT pre-composition continues heating and stirring until 80 DEG C, while it is homogeneous to verify acquisition.80 DEG C and quickly stirring under, introduceS, and be kept stirring until obtaining homogeneous.Under 80 DEG C and 1200rpm, by A Phase (obtaining in step a) is introduced into B phase (obtaining in step b), and is begun to cool by being kept stirring speed.Then it is used at 72 DEG CIt is dispensed Chlorphenesin 30 seconds with the speed of 9,500rpm.Continue to cool down in the case where being slightly agitated for.

C) it is introduced sequentially into the component of C phase at 50 DEG C, then continues to cool down in the case where being slightly agitated for.

E) it is introduced sequentially into the component of D phase at 35 DEG C, verifies the appropriate homogenieity between addition every time.PH value determination, and It is adjusted if necessary, to obtain pH value as 5.50 to 6.00.

Claims

1. a kind of gelatine composition, relative to the total weight of the gelatine composition, it includes:

At least at least one hydrocarbon ils of 50 weight %, wherein relative to the total weight of the hydrocarbon ils, the weight of isoparaffin contains Amount is 90% to 100%, and the weight content of normal paraffin hydrocarbons is 0 to 10%, and the content of the carbon of biological source is greater than or equal to 90%；With

I. the gel polymer selected from homopolymer or copolymer, the homopolymer or copolymer include to be selected from isoprene, fourth two At least one of alkene, styrene and (methyl) acrylate monomer,

Ii. non-polymer gelling agent.

2. gelatine composition as described in claim 1, wherein the gelling agent is the gelling selected from homopolymer or copolymer Polymer, the homopolymer or copolymer include to be selected from isoprene, butadiene, styrene and (methyl) acrylate extremely A kind of few monomer.

3. gelatine composition as claimed in claim 2, wherein the gel polymer is selected from homopolymer or copolymer, institute It states homopolymer or copolymer includes selected from least one of isoprene, butadiene and styrene monomer.

4. gelatine composition as claimed in claim 2 or claim 3, wherein the polymer is comprising at least one styrene list Body and copolymer selected from least one of ethylene, propylene, butadiene and isoprene monomer.

5. the gelatine composition as described in any one of claim 2 to 4, wherein the polymer be selected from star polymer, Diblock copolymer, triblock copolymer, segmented copolymer, comb polymer, radial polymers and the combination of the latter.

6. gelatine composition the invention according to any one of claims 2 to 5, wherein the polymer is selected from styrene/fourth two Alkene copolymer, styrene/isoprene copolymer, hydrogenated styrene/butadiene copolymer, hydrogenated styrene/isoprene are total Polymers, hydrogenated polyisoprene cross-linked polymer, polyisoprene homopolymer, hydrogenated styrene thermoplastic homopolymer, liquid rubber Glue and its mixture.

7. gelatine composition as described in claim 1, wherein the gelling agent is non-polymer gelling agent, is selected from:

It is preferably selected from the mineral filler of clay, montmorillonite, silicate, silica, hectorite,

It is preferably selected from the wax of native paraffin, such as vegetable wax, animal wax, ceresine and mineral tallow, and

Ammonium salt and the metal salt for being preferably selected from zinc stearate.

8. gelatine composition as described in any one of the preceding claims, wherein the hydrocarbon ils, which is selected from, includes 14 to 18 The non-cyclic isoparaffins of carbon atom.

9. gelatine composition as described in any one of the preceding claims, wherein the hydrocarbon ils includes:

Relative to the total weight of the hydrocarbon ils, weight content is 90% to 100%, is preferably 95% to 100%, preferably 98% to 100% isoparaffin；

Relative to the total weight of the hydrocarbon ils, weight content is less than or equal to 10%, is preferably less than or equal to 5%, preferably For the normal paraffin hydrocarbons less than or equal to 2%；And/or

Relative to the total weight of the hydrocarbon ils, weight content is less than or equal to 1%, is preferably less than or equal to 0.5%, is excellent It is selected as the naphthenic compound less than or equal to 100ppm；And/or

Relative to the total weight of the hydrocarbon ils, weight content is less than or equal to 500ppm, is preferably less than or equal to 300ppm, it is preferably less than or equal to 100ppm, more preferably less than or equal to 50ppm, is advantageously less than or equal to 20ppm's Aromatic compounds.

10. gelatine composition as described in any one of the preceding claims, wherein the hydrocarbon ils:

It is 230 DEG C to 340 DEG C according to the boiling temperature of standard ASTM D86, preferably 235 DEG C to 330 DEG C, more preferably 240 DEG C to 325 DEG C；And/or

It is at least 60%, preferably at least 70% according to 28 days biodegradabilities that standard OECD 306 is measured, preferably extremely Few 75%, even more preferably at east 80%；And/or

11. gelatine composition as described in any one of the preceding claims, wherein the hydrocarbon ils passes through at 80 DEG C to 180 DEG C temperature and 50 to 160 bars of pressure under catalytic hydrogenation is carried out to the deoxidation and/or isomerization of biological source charging method It obtains.

12. gelatine composition as described in any one of the preceding claims, the gross weight relative to the gelatine composition Amount, it includes 50 weight % to 99 weight %, preferably 60 weight % to 95 weight %, more preferably 70 weight % to 90 weights Measure the hydrocarbon ils and 1 weight % to 50 weight %, preferably 5 weight % to 40 weight %, more preferably 10 weight % to 30 weights of % The gelling agent of % is measured, the gelling agent is preferably selected from the gel polymer.

13. a kind of beauty, skin care or pharmaceutical composition, it includes glue described at least one any one of claims 1 to 12 Solidifyingization composition, relative to the total weight of the beauty, skin care or pharmaceutical composition, the amount of the gelatine composition is preferably 0.5% to 80%, preferably 1% to 50%, it is advantageously 5% to 30%.

14. beauty as claimed in claim 13, skin care or pharmaceutical composition, it includes:

At least one fatty material, hydrocarbon ils, the vegetable butter, rouge being selected from other than the hydrocarbon ils of vegetable oil, the gelatine composition The pure and mild ether of fat, oily ester, alkane and silicone oil；And/or

At least one additive, the additive are preferably selected from emulsifier.

15. beauty, skin care described in gelatine composition or claim 13 or 14 described in any one of claims 1 to 12 Or purposes of the pharmaceutical composition in local application, the care product, makeups articles, hair care for being especially used as skin or hair produce Product, cleansing product, perfume products, sunscreen product, lip care product such as lip gloss or lip gloss.

16. described in any one of gelatine composition or claim 13 to 15 described in any one of claims 1 to 12 Composition is used as the purposes of antidotal agent.

17. the method that a kind of pair of skin carries out cosmetic treatments comprising at least one following steps: application preferably passes through smearing Apply composition described in gelatine composition described in any one of claims 1 to 12 or claim 13 or 14.

18. the gelatine composition as described in any one of claims 1 to 12 or the composition as described in claim 13 or 14, It is used as drug.

19. the composition used as claimed in claim 18 is used as antioxidant and/or antifree radical agent and/or anti-inflammatory agent And/or anti-apoptotic agent and/or antibacterium and/or antifungal agent.