CN110464666A - Eye lip frost and preparation method thereof - Google Patents
Eye lip frost and preparation method thereof Download PDFInfo
- Publication number
- CN110464666A CN110464666A CN201910865853.4A CN201910865853A CN110464666A CN 110464666 A CN110464666 A CN 110464666A CN 201910865853 A CN201910865853 A CN 201910865853A CN 110464666 A CN110464666 A CN 110464666A
- Authority
- CN
- China
- Prior art keywords
- weight
- parts
- lip cream
- eye lip
- emulsifier
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000002360 preparation method Methods 0.000 title abstract description 14
- -1 trihydroxy methyl hexyl lactone Chemical class 0.000 claims abstract description 60
- BTCSSZJGUNDROE-UHFFFAOYSA-N gamma-aminobutyric acid Chemical compound NCCCC(O)=O BTCSSZJGUNDROE-UHFFFAOYSA-N 0.000 claims abstract description 53
- 238000011049 filling Methods 0.000 claims abstract description 31
- 239000003995 emulsifying agent Substances 0.000 claims abstract description 29
- 230000003020 moisturizing effect Effects 0.000 claims abstract description 29
- 229960003692 gamma aminobutyric acid Drugs 0.000 claims abstract description 26
- OGNSCSPNOLGXSM-UHFFFAOYSA-N (+/-)-DABA Natural products NCCC(N)C(O)=O OGNSCSPNOLGXSM-UHFFFAOYSA-N 0.000 claims abstract description 25
- 229920006037 cross link polymer Polymers 0.000 claims abstract description 22
- PMMYEEVYMWASQN-DMTCNVIQSA-N Hydroxyproline Chemical compound O[C@H]1CN[C@H](C(O)=O)C1 PMMYEEVYMWASQN-DMTCNVIQSA-N 0.000 claims abstract description 19
- PMMYEEVYMWASQN-UHFFFAOYSA-N dl-hydroxyproline Natural products OC1C[NH2+]C(C([O-])=O)C1 PMMYEEVYMWASQN-UHFFFAOYSA-N 0.000 claims abstract description 19
- 229960002591 hydroxyproline Drugs 0.000 claims abstract description 19
- FGMPLJWBKKVCDB-UHFFFAOYSA-N trans-L-hydroxy-proline Natural products ON1CCCC1C(O)=O FGMPLJWBKKVCDB-UHFFFAOYSA-N 0.000 claims abstract description 19
- 239000003974 emollient agent Substances 0.000 claims abstract description 14
- 239000006071 cream Substances 0.000 claims description 54
- 229920002385 Sodium hyaluronate Polymers 0.000 claims description 37
- 229940010747 sodium hyaluronate Drugs 0.000 claims description 37
- 239000004205 dimethyl polysiloxane Substances 0.000 claims description 33
- 235000013870 dimethyl polysiloxane Nutrition 0.000 claims description 33
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 claims description 33
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 claims description 18
- QZLXCFQVOCEKSX-NOCHOARKSA-N (2s,4r)-1-hexadecanoyl-4-hexadecanoyloxypyrrolidine-2-carboxylic acid Chemical compound CCCCCCCCCCCCCCCC(=O)O[C@@H]1C[C@@H](C(O)=O)N(C(=O)CCCCCCCCCCCCCCC)C1 QZLXCFQVOCEKSX-NOCHOARKSA-N 0.000 claims description 16
- 239000003795 chemical substances by application Substances 0.000 claims description 16
- DTPCFIHYWYONMD-UHFFFAOYSA-N decaethylene glycol Chemical compound OCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO DTPCFIHYWYONMD-UHFFFAOYSA-N 0.000 claims description 14
- 239000000945 filler Substances 0.000 claims description 13
- 229940008099 dimethicone Drugs 0.000 claims description 11
- 239000003755 preservative agent Substances 0.000 claims description 11
- 230000002335 preservative effect Effects 0.000 claims description 11
- 230000008439 repair process Effects 0.000 claims description 11
- 239000007957 coemulsifier Substances 0.000 claims description 10
- 238000002156 mixing Methods 0.000 claims description 10
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 9
- 238000000034 method Methods 0.000 claims description 9
- LEACJMVNYZDSKR-UHFFFAOYSA-N 2-octyldodecan-1-ol Chemical compound CCCCCCCCCCC(CO)CCCCCCCC LEACJMVNYZDSKR-UHFFFAOYSA-N 0.000 claims description 8
- BTFJIXJJCSYFAL-UHFFFAOYSA-N arachidyl alcohol Natural products CCCCCCCCCCCCCCCCCCCCO BTFJIXJJCSYFAL-UHFFFAOYSA-N 0.000 claims description 8
- 239000002738 chelating agent Substances 0.000 claims description 8
- 239000000203 mixture Substances 0.000 claims description 8
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 7
- 229920002521 macromolecule Polymers 0.000 claims description 7
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 claims description 6
- 239000007798 antifreeze agent Substances 0.000 claims description 6
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 claims description 6
- 239000000811 xylitol Substances 0.000 claims description 6
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 claims description 6
- 235000010447 xylitol Nutrition 0.000 claims description 6
- 229960002675 xylitol Drugs 0.000 claims description 6
- 229910052751 metal Inorganic materials 0.000 claims description 5
- 239000002184 metal Substances 0.000 claims description 5
- KZRXPHCVIMWWDS-AWEZNQCLSA-N (4S)-4-amino-5-dodecanoyloxy-5-oxopentanoic acid Chemical compound CCCCCCCCCCCC(=O)OC(=O)[C@@H](N)CCC(O)=O KZRXPHCVIMWWDS-AWEZNQCLSA-N 0.000 claims description 4
- 239000004698 Polyethylene Substances 0.000 claims description 4
- HGKOWIQVWAQWDS-UHFFFAOYSA-N bis(16-methylheptadecyl) 2-hydroxybutanedioate Chemical compound CC(C)CCCCCCCCCCCCCCCOC(=O)CC(O)C(=O)OCCCCCCCCCCCCCCCC(C)C HGKOWIQVWAQWDS-UHFFFAOYSA-N 0.000 claims description 4
- 229930182478 glucoside Natural products 0.000 claims description 4
- 150000008131 glucosides Chemical class 0.000 claims description 4
- 229940071085 lauroyl glutamate Drugs 0.000 claims description 4
- 229920000573 polyethylene Polymers 0.000 claims description 4
- KZVAAIRBJJYZOW-VPENINKCSA-N (2r,3r,4s)-2-(hydroxymethyl)oxolane-3,4-diol Chemical compound OC[C@H]1OC[C@H](O)[C@H]1O KZVAAIRBJJYZOW-VPENINKCSA-N 0.000 claims description 3
- 229920001503 Glucan Polymers 0.000 claims description 3
- 229940083987 anhydroxylitol Drugs 0.000 claims description 3
- 229960000541 cetyl alcohol Drugs 0.000 claims description 3
- PKPOVTYZGGYDIJ-UHFFFAOYSA-N dioctyl carbonate Chemical compound CCCCCCCCOC(=O)OCCCCCCCC PKPOVTYZGGYDIJ-UHFFFAOYSA-N 0.000 claims description 3
- 235000011187 glycerol Nutrition 0.000 claims description 3
- 125000003976 glyceryl group Chemical group [H]C([*])([H])C(O[H])([H])C(O[H])([H])[H] 0.000 claims description 3
- 230000014759 maintenance of location Effects 0.000 claims description 3
- BXWNKGSJHAJOGX-UHFFFAOYSA-N n-hexadecyl alcohol Natural products CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 claims description 3
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 claims description 2
- 239000003205 fragrance Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 52
- 230000037303 wrinkles Effects 0.000 abstract description 31
- 102000008186 Collagen Human genes 0.000 abstract description 8
- 108010035532 Collagen Proteins 0.000 abstract description 8
- 229920001436 collagen Polymers 0.000 abstract description 8
- 239000004615 ingredient Substances 0.000 abstract description 8
- 239000002537 cosmetic Substances 0.000 abstract description 2
- 238000012423 maintenance Methods 0.000 abstract 2
- 238000010612 desalination reaction Methods 0.000 abstract 1
- 210000003491 skin Anatomy 0.000 description 45
- 239000012071 phase Substances 0.000 description 44
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 35
- 238000003756 stirring Methods 0.000 description 21
- 239000003921 oil Substances 0.000 description 16
- 239000005057 Hexamethylene diisocyanate Substances 0.000 description 11
- 238000011156 evaluation Methods 0.000 description 11
- RRAMGCGOFNQTLD-UHFFFAOYSA-N hexamethylene diisocyanate Chemical compound O=C=NCCCCCCN=C=O RRAMGCGOFNQTLD-UHFFFAOYSA-N 0.000 description 11
- 238000012360 testing method Methods 0.000 description 10
- 238000005562 fading Methods 0.000 description 7
- 238000005086 pumping Methods 0.000 description 7
- 230000000052 comparative effect Effects 0.000 description 6
- 230000001804 emulsifying effect Effects 0.000 description 6
- 238000010438 heat treatment Methods 0.000 description 6
- 239000010410 layer Substances 0.000 description 6
- 239000000047 product Substances 0.000 description 6
- 210000001519 tissue Anatomy 0.000 description 5
- 230000000007 visual effect Effects 0.000 description 5
- CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 description 4
- 230000002421 anti-septic effect Effects 0.000 description 4
- 239000011148 porous material Substances 0.000 description 4
- 230000002829 reductive effect Effects 0.000 description 4
- 230000002195 synergetic effect Effects 0.000 description 4
- 150000001413 amino acids Chemical class 0.000 description 3
- 230000002528 anti-freeze Effects 0.000 description 3
- 230000001153 anti-wrinkle effect Effects 0.000 description 3
- 238000001816 cooling Methods 0.000 description 3
- 210000004207 dermis Anatomy 0.000 description 3
- 239000000686 essence Substances 0.000 description 3
- 230000007774 longterm Effects 0.000 description 3
- 239000000843 powder Substances 0.000 description 3
- 238000012216 screening Methods 0.000 description 3
- 210000001732 sebaceous gland Anatomy 0.000 description 3
- QCDWFXQBSFUVSP-UHFFFAOYSA-N 2-phenoxyethanol Chemical compound OCCOC1=CC=CC=C1 QCDWFXQBSFUVSP-UHFFFAOYSA-N 0.000 description 2
- 241000220317 Rosa Species 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 239000000835 fiber Substances 0.000 description 2
- IPCSVZSSVZVIGE-UHFFFAOYSA-N hexadecanoic acid Chemical compound CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 description 2
- 238000000265 homogenisation Methods 0.000 description 2
- BJRNKVDFDLYUGJ-RMPHRYRLSA-N hydroquinone O-beta-D-glucopyranoside Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=CC=C(O)C=C1 BJRNKVDFDLYUGJ-RMPHRYRLSA-N 0.000 description 2
- 230000006872 improvement Effects 0.000 description 2
- 230000005923 long-lasting effect Effects 0.000 description 2
- 229910052943 magnesium sulfate Inorganic materials 0.000 description 2
- 235000019341 magnesium sulphate Nutrition 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 229910021645 metal ion Inorganic materials 0.000 description 2
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 description 2
- 244000005700 microbiome Species 0.000 description 2
- 210000003205 muscle Anatomy 0.000 description 2
- 229960005323 phenoxyethanol Drugs 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 230000001737 promoting effect Effects 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 210000004243 sweat Anatomy 0.000 description 2
- 230000037331 wrinkle reduction Effects 0.000 description 2
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 description 1
- MXOAEAUPQDYUQM-QMMMGPOBSA-N (S)-chlorphenesin Chemical compound OC[C@H](O)COC1=CC=C(Cl)C=C1 MXOAEAUPQDYUQM-QMMMGPOBSA-N 0.000 description 1
- XDOFQFKRPWOURC-UHFFFAOYSA-N 16-methylheptadecanoic acid Chemical compound CC(C)CCCCCCCCCCCCCCC(O)=O XDOFQFKRPWOURC-UHFFFAOYSA-N 0.000 description 1
- NCZPCONIKBICGS-UHFFFAOYSA-N 3-(2-ethylhexoxy)propane-1,2-diol Chemical compound CCCCC(CC)COCC(O)CO NCZPCONIKBICGS-UHFFFAOYSA-N 0.000 description 1
- 241001474374 Blennius Species 0.000 description 1
- 244000020518 Carthamus tinctorius Species 0.000 description 1
- 235000003255 Carthamus tinctorius Nutrition 0.000 description 1
- 235000007866 Chamaemelum nobile Nutrition 0.000 description 1
- AEMOLEFTQBMNLQ-AQKNRBDQSA-N D-glucopyranuronic acid Chemical compound OC1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O AEMOLEFTQBMNLQ-AQKNRBDQSA-N 0.000 description 1
- XMSXQFUHVRWGNA-UHFFFAOYSA-N Decamethylcyclopentasiloxane Chemical compound C[Si]1(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O1 XMSXQFUHVRWGNA-UHFFFAOYSA-N 0.000 description 1
- 239000003109 Disodium ethylene diamine tetraacetate Substances 0.000 description 1
- ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical compound [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 description 1
- 102000016942 Elastin Human genes 0.000 description 1
- 108010014258 Elastin Proteins 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 244000224182 Gomphrena globosa Species 0.000 description 1
- 244000308760 Helichrysum petiolatum Species 0.000 description 1
- HXEACLLIILLPRG-YFKPBYRVSA-N L-pipecolic acid Chemical compound [O-]C(=O)[C@@H]1CCCC[NH2+]1 HXEACLLIILLPRG-YFKPBYRVSA-N 0.000 description 1
- 206010024552 Lip dry Diseases 0.000 description 1
- 239000004367 Lipase Substances 0.000 description 1
- 102000004882 Lipase Human genes 0.000 description 1
- 108090001060 Lipase Proteins 0.000 description 1
- 244000042664 Matricaria chamomilla Species 0.000 description 1
- 235000007232 Matricaria chamomilla Nutrition 0.000 description 1
- 235000021314 Palmitic acid Nutrition 0.000 description 1
- 239000004721 Polyphenylene oxide Substances 0.000 description 1
- 244000181025 Rosa gallica Species 0.000 description 1
- 239000007983 Tris buffer Substances 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 229940124277 aminobutyric acid Drugs 0.000 description 1
- 210000004381 amniotic fluid Anatomy 0.000 description 1
- 230000003712 anti-aging effect Effects 0.000 description 1
- 239000008346 aqueous phase Substances 0.000 description 1
- 229960000271 arbutin Drugs 0.000 description 1
- 210000001188 articular cartilage Anatomy 0.000 description 1
- 229940107666 astragalus root Drugs 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 230000004397 blinking Effects 0.000 description 1
- CDQSJQSWAWPGKG-UHFFFAOYSA-N butane-1,1-diol Chemical compound CCCC(O)O CDQSJQSWAWPGKG-UHFFFAOYSA-N 0.000 description 1
- 230000003197 catalytic effect Effects 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 229960003993 chlorphenesin Drugs 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 230000008602 contraction Effects 0.000 description 1
- 210000000695 crystalline len Anatomy 0.000 description 1
- 125000004122 cyclic group Chemical group 0.000 description 1
- 239000008367 deionised water Substances 0.000 description 1
- 229910021641 deionized water Inorganic materials 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 235000019301 disodium ethylene diamine tetraacetate Nutrition 0.000 description 1
- 125000003438 dodecyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 239000012154 double-distilled water Substances 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 210000004177 elastic tissue Anatomy 0.000 description 1
- 229920002549 elastin Polymers 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 210000001339 epidermal cell Anatomy 0.000 description 1
- 210000002615 epidermis Anatomy 0.000 description 1
- 229940100524 ethylhexylglycerin Drugs 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 238000004299 exfoliation Methods 0.000 description 1
- 230000001815 facial effect Effects 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 229940097042 glucuronate Drugs 0.000 description 1
- 229920002674 hyaluronan Polymers 0.000 description 1
- 229960003160 hyaluronic acid Drugs 0.000 description 1
- 238000003384 imaging method Methods 0.000 description 1
- 238000009776 industrial production Methods 0.000 description 1
- 238000005342 ion exchange Methods 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- HXEACLLIILLPRG-RXMQYKEDSA-N l-pipecolic acid Natural products OC(=O)[C@H]1CCCCN1 HXEACLLIILLPRG-RXMQYKEDSA-N 0.000 description 1
- 150000002596 lactones Chemical class 0.000 description 1
- 239000003446 ligand Substances 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- 235000019421 lipase Nutrition 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 239000008308 lipophilic cream Substances 0.000 description 1
- 230000001050 lubricating effect Effects 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 description 1
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 description 1
- 229960002216 methylparaben Drugs 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- WQEPLUUGTLDZJY-UHFFFAOYSA-N n-Pentadecanoic acid Natural products CCCCCCCCCCCCCCC(O)=O WQEPLUUGTLDZJY-UHFFFAOYSA-N 0.000 description 1
- 229930014626 natural product Natural products 0.000 description 1
- 230000009707 neogenesis Effects 0.000 description 1
- AEIJTFQOBWATKX-UHFFFAOYSA-N octane-1,2-diol Chemical compound CCCCCCC(O)CO AEIJTFQOBWATKX-UHFFFAOYSA-N 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 229920001558 organosilicon polymer Polymers 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- BJRNKVDFDLYUGJ-UHFFFAOYSA-N p-hydroxyphenyl beta-D-alloside Natural products OC1C(O)C(O)C(CO)OC1OC1=CC=C(O)C=C1 BJRNKVDFDLYUGJ-UHFFFAOYSA-N 0.000 description 1
- 125000000913 palmityl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 229940094332 peg-8 dimethicone Drugs 0.000 description 1
- 230000037368 penetrate the skin Effects 0.000 description 1
- 239000002304 perfume Substances 0.000 description 1
- 239000012466 permeate Substances 0.000 description 1
- 210000002826 placenta Anatomy 0.000 description 1
- 229920000570 polyether Polymers 0.000 description 1
- 229940110977 polyglycerin-4 Drugs 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 239000008213 purified water Substances 0.000 description 1
- 230000008707 rearrangement Effects 0.000 description 1
- 238000001223 reverse osmosis Methods 0.000 description 1
- 238000007665 sagging Methods 0.000 description 1
- 210000002374 sebum Anatomy 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 229920002379 silicone rubber Polymers 0.000 description 1
- 230000037393 skin firmness Effects 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 230000001502 supplementing effect Effects 0.000 description 1
- 239000002344 surface layer Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- UEUXEKPTXMALOB-UHFFFAOYSA-J tetrasodium;2-[2-[bis(carboxylatomethyl)amino]ethyl-(carboxylatomethyl)amino]acetate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]C(=O)CN(CC([O-])=O)CCN(CC([O-])=O)CC([O-])=O UEUXEKPTXMALOB-UHFFFAOYSA-J 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/31—Hydrocarbons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/342—Alcohols having more than seven atoms in an unbroken chain
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
- A61K8/4913—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having five membered rings, e.g. pyrrolidone carboxylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/63—Steroids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/86—Polyethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/89—Polysiloxanes
- A61K8/891—Polysiloxanes saturated, e.g. dimethicone, phenyl trimethicone, C24-C28 methicone or stearyl dimethicone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/001—Preparations for care of the lips
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/005—Preparations for sensitive skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Dermatology (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Cosmetics (AREA)
Abstract
The present invention relates to a kind of lip frosts and preparation method thereof, belong to cosmetic technical field.The eye lip frost includes following components: emulsifier: 2.0~6.0 parts by weight, preferably 3.0~4.5 parts by weight；Emollient: 3.0~18.0 parts by weight, preferably 6.0~15.0 parts by weight；Moisturizing component: 5.0~15.0 parts by weight, preferably 7.0~12.0 parts by weight；Filling components: 1.0~5.0 parts by weight, preferably 1.5~4.5 parts by weight；Maintenance ingredient: 0.05~5.0 parts by weight, preferably 0.1~4.0 parts by weight；Wherein, the filling components include HDI/ trihydroxy methyl hexyl lactone cross-linked polymer；The maintenance ingredient includes the combination of one or more of hydroxyproline or derivatives thereof, γ-aminobutyric acid.Have the effect of filling eye wrinkle-removing and cheilogramma immediately the object of the present invention is to provide a kind of, but can efficient moisture-retention, promote the generation of collagen, the eye lip frost of the effect of long-acting desalination wrinkle and cheilogramma.
Description
Technical Field
The invention belongs to the technical field of cosmetics, and particularly relates to eye-lip cream and a preparation method thereof.
Background
The dry environment results in dry lips, pronounced lips lines, and even peeling, discoloring the red lips, which is less obtrusive because the skin tissue structure on the lips is thin, 1/3 times the thickness of the body skin. Because it has no sweat pores and no sebaceous glands, it is naturally sensitive to the environment such as dry air and low temperature in autumn. Drying of the lips can cause significant cheilogramma, exfoliation, and loss of color even with oily lipstick. In addition, the muscles of the two lips are thin, soft and tender, and smile, drink water, eat and speak, and are easy to be dragged to generate wrinkles.
The formation of eye wrinkles is mainly due to the dry and thin epidermis tissues and insufficient supplement of collagen and elastic fibers in the dermis layer, so that the eye wrinkles become thin and lose reticular supporting force. The skin loses elasticity and does not recover after being squeezed, so that sagging and wrinkles of the skin are formed. If the function of sebaceous glands is reduced, sebum secretion is reduced, sebaceous membranes are not easy to form, moisture in horny layer is easy to lose, and skin becomes dry, and because the blinking frequency of eyes reaches ten thousand times a day, the eye skin is easy to generate tiny wrinkles.
The common skin tissues of the human eyes and lips are: the structural layer is very thin, about 0.55cm, which is only 1/3 of the thickness of the skin of the human body, and meanwhile, the two layers have no sweat pores and no characteristics such as sebaceous glands, and the eye lines and the lip lines are respectively generated due to the dryness and thinning of the epidermal tissues and the like.
The existing lip creams on the market are generally divided into two types, one type has the effect of filling fine lines instantly by adding a large amount of organic silicon elastomers, and the other type has the effect of increasing the water content of the skin cuticle by adding a moisturizing component and promoting the generation of collagen to achieve the moisturizing, elastic and compact effects.
Cited document 1 discloses a rose immediate repair eye cream, and specifically discloses an immediate repair eye cream comprising: rosa damascena extract, arbutin, red-chocolate plum, chamomile, globe amaranth, safflower, forget-sole, rose hip, hyaluronic acid, pearl powder, seaweed extract, astragalus root, cyclopentasiloxane, helichrysum extract, glucoside, ethoxylated methyl glucose fatty acid ester, and phenoxyethanol. However, the eye cream has a very limited immediate improvement effect on the skin around the eyes.
Cited document 1: CN109549912A
Disclosure of Invention
Problems to be solved by the invention
In view of the technical problems in the prior art, the invention aims to provide an eye and lip cream which has the effects of filling wrinkles and lip lines on eyes instantly, preserving moisture efficiently, promoting the generation of collagen and fading the wrinkles and the lip lines for a long time.
Furthermore, the invention also provides a preparation method of the eye and lip cream, which is simple in preparation method and easy in obtaining of raw materials.
Means for solving the problems
[1] The invention provides an eye-lip cream, which comprises the following components:
emulsifier: 2.0 to 6.0 parts by weight, preferably 3.0 to 4.5 parts by weight;
and (3) an emollient: 3.0 to 18.0 parts by weight, preferably 6.0 to 15.0 parts by weight;
moisture retention component: 5.0 to 15.0 parts by weight, preferably 7.0 to 12.0 parts by weight;
filling components: 1.0 to 5.0 parts by weight, preferably 1.5 to 4.5 parts by weight;
repairing components: 0.05 to 5.0 parts by weight, preferably 0.1 to 4.0 parts by weight; wherein,
the filling component comprises HDI/trihydroxymethyl hexyl lactone cross-linked polymer;
the repairing component comprises one or the combination of more than two of hydroxyproline or derivatives thereof and gamma-aminobutyric acid.
[2] The lip cream according to [1], the repair ingredient comprising hydroxyproline or a derivative thereof and gamma-aminobutyric acid; preferably, the first and second electrodes are formed of a metal,
the addition amount of the hydroxyproline or the derivatives thereof is 0.95-4.95 parts by weight, preferably 1.9-3.9 parts by weight;
the addition amount of the gamma-aminobutyric acid is 0.05 to 0.5 part by weight, preferably 0.1 to 0.3 part by weight.
[3] The lip cream according to [2], wherein the hydroxyproline or a derivative thereof comprises dipalmitoyl hydroxyproline.
[4] The eye lip cream according to any one of [1] to [3], wherein the moisturizing component comprises small-molecule sodium hyaluronate or/and macromolecular sodium hyaluronate, the addition amount of the small-molecule sodium hyaluronate is 0.01 to 0.3 part by weight, and the addition amount of the macromolecular sodium hyaluronate is 0.01 to 0.2 part by weight; wherein,
the number average molecular weight of the micromolecular sodium hyaluronate is 3000 Da-10000 Da,
the number average molecular weight of the macromolecular sodium hyaluronate is more than 10kDa to 1000 kDa.
[5] The eye-lip cream according to any one of [1] to [4], wherein the emulsifier comprises a main emulsifier and a co-emulsifier; wherein,
the addition amount of the main emulsifier is 1.5-4.5 parts by weight; the addition amount of the co-emulsifier is 0.5-1.5 parts by weight; preferably, the first and second electrodes are formed of a metal,
the main emulsifier comprises polydimethylsiloxane and polydimethylsiloxane PEG-10/15 cross-linked polymer;
the coemulsifier comprises PEG-10 polydimethylsiloxane.
[6] The lip cream according to any one of [1] to [5], wherein the emollient comprises one or a combination of two or more of octyldodecanol, hydrogenated polydecene, dioctyl carbonate, polydimethylsiloxane, ethylhexyl cetyl alcohol, phytosterol/octyldodecanol lauroyl glutamate, diisostearyl malate, and dimethicone crosspolymer.
[7] The eye lip cream according to any one of [4] to [6], wherein the moisturizing component further comprises one or more of glycerol, propylene glycol, butylene glycol, oat glucan, glyceryl polyether-26 and xylitol-based glucoside/anhydroxylitol/xylitol.
[8] The lip cream according to any one of [1] to [7], further comprising a film-forming agent; preferably, the addition amount of the film forming agent is 0.1-1.0 part by weight, preferably 0.3-0.7 part by weight;
more preferably, the film former comprises polyethylene.
[9] The lip cream according to any one of [1] to [8], further comprising one or a combination of more than two of auxiliary fillers, antifreeze agents, chelating agents, essences and preservative components.
[10] The invention also provides a preparation method of the eye lip cream in any one of the items [1] to [9], which comprises the step of mixing the components of the eye lip cream.
ADVANTAGEOUS EFFECTS OF INVENTION
The eye and lip cream disclosed by the invention combines a plurality of components, reasonably designs the weight ratio of the components, and designs the eye and lip cream which can be used for instantly filling eye fine lines and lip fine lines and can be used for repairing the eye fine lines and the lip fine lines for a long time. The eye and lip cream can instantly conceal fine lines of eyes and lips, and can improve the fine lines of eyes and lips after long-term use due to the fact that the eye and lip cream contains deep moisturizing and repairing components.
Furthermore, the eye and lip cream is simple in preparation method, easy in obtaining of raw materials and suitable for mass production.
Detailed Description
The present invention will be described in detail below. The technical features described below are explained based on typical embodiments and specific examples of the present invention, but the present invention is not limited to these embodiments and specific examples.
Furthermore, in the following detailed description, numerous specific details are set forth in order to provide a better understanding of the present invention. It will be understood by those skilled in the art that the present invention may be practiced without some of these specific details. In other instances, methods, means, devices and steps which are well known to those skilled in the art have not been described in detail so as not to obscure the invention.
It should be noted that:
in the present specification, the meaning of "may" or "may" includes both the meaning of performing a certain process and the meaning of not performing a certain process.
As used herein, the term "optional" or "optional" is used to indicate that certain substances, components, performance steps, application conditions, and the like are used or not used.
In the present specification, reference to "some particular/preferred embodiments," "other particular/preferred embodiments," "embodiments," and the like, means that a particular element (e.g., feature, structure, property, and/or characteristic) described in connection with the embodiment is included in at least one embodiment described herein, and may or may not be present in other embodiments. In addition, it is to be understood that the described elements may be combined in any suitable manner in the various embodiments.
All units used in the present invention are international standard units unless otherwise stated, and numerical values and numerical ranges appearing in the present invention should be understood to include errors allowed in industrial production.
< first aspect >
The invention provides an eye lip cream, which comprises the following components:
emulsifier: 2.0 to 6.0 parts by weight, preferably 3.0 to 4.5 parts by weight;
and (3) an emollient: 3.0 to 18.0 parts by weight, preferably 6.0 to 15.0 parts by weight;
moisture retention component: 5.0 to 15.0 parts by weight, preferably 7.0 to 12.0 parts by weight;
filling components: 1.0 to 5.0 parts by weight, preferably 1.5 to 4.5 parts by weight;
repairing components: 0.05 to 5.0 parts by weight, preferably 0.1 to 4.0 parts by weight; wherein,
the filling component comprises HDI/trihydroxymethyl hexyl lactone cross-linked polymer;
the repairing component comprises one or the combination of more than two of hydroxyproline or derivatives thereof and gamma-aminobutyric acid.
The eye lip cream can achieve the effect of instantly filling fine lines in a short time, thereby realizing the effect of instantly hiding eye wrinkles and lip lines. On the other hand, after the eye lip cream is used for a long time, the effect of fading eye wrinkles and lip wrinkles in a long-term manner can be achieved. Specifically, the method comprises the following steps:
filling composition
In the present invention, the filler component comprises an HDI/trimethylolhexyllactone crosspolymer. The HDI/trimethylol hexyl lactone crosspolymer is an elastomeric microspheroidal particle and HDI (hexamethylene diisocyanate) is hexamethylene diisocyanate.
Specifically, in the present invention, the HDI/trimethylol hexyl lactone crosspolymer can impart a smooth lubricating feeling to the skin and supply an appropriate amount of moisture. It has both the effect of filling fine lines instantly and the effect of pore blurring, and has the effect of filling the eyes and lips instantly. The excellent optical filling effect and the luxurious elastic soft texture of the HDI/trimethylol hexyl lactone cross-linked polymer can bring about an instant fine line filling effect, invisible fine lines around eyes and lip lines.
In the present invention, the filler component is added in an amount of 1.0 to 5.0 parts by weight, preferably 1.5 to 4.5 parts by weight. When the addition amount of the filling component is less than 1.0 part by weight, the eye lip cream is difficult to achieve the effect of filling fine wrinkles instantly, the pore blurring effect is poor, and the effect of filling the eye lip wrinkles instantly cannot be achieved. When the adding amount of the filling component is more than 5.0 parts by weight, the paste body can be rubbed when being smeared. Specifically, the filler component may be added in an amount of 2.0 parts by weight, 2.5 parts by weight, 3.0 parts by weight, 3.5 parts by weight, 4.0 parts by weight, or the like.
Repairing composition
In the present invention, the repairing component includes one or a combination of two or more of hydroxyproline or a derivative thereof and gamma-aminobutyric acid. In the present invention, the repairing component is added in an amount of 0.05 to 5.0 parts by weight, preferably 0.1 to 4.0 parts by weight. When the addition amount of the repairing component is less than 0.05 part by weight, good effects of reducing fine lines and resisting wrinkles are difficult to achieve. When the amount of the repairing ingredient added is more than 5.0 parts by weight, the burden on the skin is large. Specifically, the repair component may be added in an amount of 0.15 parts by weight, 0.5 parts by weight, 1 part by weight, 1.5 parts by weight, 2.5 parts by weight, 3.0 parts by weight, 3.5 parts by weight, 4.5 parts by weight, or the like.
Further, in some specific embodiments of the present invention, the present invention may use a combination of hydroxyproline or derivatives thereof and gamma-aminobutyric acid as a repair ingredient. The combination of hydroxyproline or derivatives thereof and gamma-aminobutyric acid can generate a synergistic effect, and can achieve the effect of better fading fine wrinkles.
Specifically, in the present invention, when a combination of hydroxyproline or a derivative thereof and γ -aminobutyric acid is used as a repair ingredient, the amount of hydroxyproline or a derivative thereof added is 0.95 to 4.95 parts by weight, preferably 1.9 to 3.9 parts by weight; the addition amount of the gamma-aminobutyric acid is 0.05 to 0.5 part by weight, preferably 0.1 to 0.3 part by weight.
Preferably, in some particular embodiments of the invention, dipalmitoyl hydroxyproline and/or gamma aminobutyric acid are used as the repair ingredient. Preferably, when dipalmitoyl hydroxyproline and gamma-aminobutyric acid are used as repair components, the synergistic effect is more excellent, and the effect of better fading fine wrinkles can be achieved.
DipalMitoyl hydroxyproline (DPHP) is synthesized from natural products palmitic acid and natural amino acid hydroxyproline. The fat group carried by hydroxyproline effectively improves the affinity absorption capacity of the skin to hydroxyproline. The dipalmitoyl hydroxyproline is released under the action of lipase after entering the skin, can stimulate the rearrangement of collagen, shrink collagen fibers, recover the skin firmness, protect elastin from being damaged by enzyme, eliminate oxygen free radicals and have good triple skin tightening effects. In the invention, dipalmitoyl hydroxyproline is a lipid biological carrier hydroxyproline, which can promote collagen fiber contraction, protect skin supporting tissues, achieve the effects of tightening and resisting wrinkles, and achieve the effect of improving wrinkles after long-term use. Meanwhile, the skin-care product also has the functions of moistening the skin and restoring the vitality of the skin.
Gamma-aminobutyric acid (GABA), 4-aminobutyric acid, another name: aminobutyric acid, pipecolic acid. In the invention, the gamma-aminobutyric acid is a natural amino acid, has small molecular weight, can quickly penetrate the skin, relax tense muscles, remarkably reduce fine lines, fade wrinkles, promote the neogenesis of epidermal cells and the synthesis of sodium hyaluronate and collagen, repair damaged skin, and enable the skin to recover young, and has excellent anti-aging effect.
Specifically, in the present invention, dipalmitoyl hydroxyproline may be added in an amount of 0.95 to 4.95 parts by weight, preferably 1.9 to 3.9 parts by weight. When the adding amount of the dipalmitoyl hydroxyproline is 0.95-4.95 parts by weight, the dipalmitoyl hydroxyproline has a good anti-wrinkle effect, is more flexible to skin, has a better moisturizing effect, and has the effects of resisting wrinkles and improving skin activity. However, when the amount of dipalmitoyl hydroxyproline added is more than 4.95 parts by weight, the anti-wrinkle effect is not increased. In order to sufficiently exert the technical effect of dipalmitoyl hydroxyproline, the amount of dipalmitoyl hydroxyproline added may be 1.9 to 3.9 parts by weight. For example: the dipalmitoyl hydroxyproline may be added in an amount of 1.5 parts by weight, 2.0 parts by weight, 2.5 parts by weight, 3.0 parts by weight, 3.5 parts by weight, 4.0 parts by weight, 4.5 parts by weight, or the like.
In the invention, when the addition amount of the gamma-aminobutyric acid is 0.05-0.5 part by weight, the gamma-aminobutyric acid has the effects of reducing fine lines, fading wrinkles and resisting aging. In order to fully exert the technical effect of the gamma-aminobutyric acid, the addition amount of the gamma-aminobutyric acid may be 0.1 to 0.3 part by weight. In addition, in the present invention, when the amount of gamma-aminobutyric acid added is more than 0.5 parts by weight, it is slightly irritating to the skin. Specifically, the gamma-aminobutyric acid may be added in an amount of 0.1 parts by weight, 0.15 parts by weight, 0.2 parts by weight, 0.25 parts by weight, 0.3 parts by weight, 0.35 parts by weight, or 0.4 parts by weight, or the like.
Moisturizing component
In the present invention, the moisture-retaining component is added in an amount of 5.0 to 15.0 parts by weight, preferably 7.0 to 12.0 parts by weight. When the amount of the moisturizing component added is less than 5.0 parts by weight, the lip cream is difficult to achieve a good moisturizing effect. When the amount of the moisturizing component added is more than 15.0 parts by weight, the skin feel is heavy and the use effect is poor. Specifically, the moisturizing component can be added in an amount of 6.0 parts by weight, 8.0 parts by weight, 9.0 parts by weight, 10.0 parts by weight, 11.0 parts by weight, 13.0 parts by weight, 14.0 parts by weight, or the like.
The specific composition of the moisturizing component of the present invention is not particularly limited, and may be any of those commonly used in the art. For example: one or more of sodium hyaluronate, glycerin, propylene glycol, butanediol, oat glucan, glyceryl polyether-26, xylitol-based glucoside/anhydroxylitol/xylitol, etc.
Sodium hyaluronate is an inherent component of human body, is a kind of glucuronate, has no species specificity, is widely present in placenta, amniotic fluid, crystalline lens, articular cartilage, skin dermis and other tissues, and exogenous sodium hyaluronate is used for supplementing endogenous sodium hyaluronate of skin. The relative humidity of the surrounding environment has less effect on its moisturizing properties than other moisturizing agents.
In some specific embodiments of the invention, the moisturizing component comprises a small molecule sodium hyaluronate or/and a large molecule sodium hyaluronate; wherein the number average molecular weight of the small-molecule sodium hyaluronate is 3000-10000 Da, and the number average molecular weight of the large-molecule sodium hyaluronate is more than 10 kDa-1000 kDa.
In the invention, when the number average molecular weight of the small-molecule sodium hyaluronate is 3000-10000 Da, the small-molecular-weight sodium hyaluronate can be absorbed through skin and deeply penetrate into a dermis layer for deep moisturizing. The number average molecular weight of the macromolecular sodium hyaluronate is more than 10 kDa-1000 kDa, and the macromolecular sodium hyaluronate is not easy to permeate through the skin for absorption, and a layer of protective film can be formed on the surface of the skin to prevent the water in the skin from evaporating.
In some specific embodiments of the invention, the moisturizing component comprises a small molecule sodium hyaluronate and a large molecule sodium hyaluronate. The small-molecule sodium hyaluronate and the large-molecule sodium hyaluronate are matched for use, so that a synergistic effect can be achieved, a more excellent moisturizing effect is obtained, and the generation of fine wrinkles is further reduced.
In some specific embodiments of the present invention, the small molecule sodium hyaluronate is added in an amount of 0.01 to 0.3 parts by weight, and the large molecule sodium hyaluronate is added in an amount of 0.01 to 0.2 parts by weight. At this time, the effects of the moisturizing component of the present invention can be effectively exerted. Specifically, the addition amount of the small molecule sodium hyaluronate may be 0.05, 0.10, 0.15, 0.20, 0.25, or the like by weight; the amount of the macromolecular sodium hyaluronate added may be 0.05 parts by weight, 0.10 parts by weight, 0.15 parts by weight, or the like.
Emulsifier
In some specific embodiments of the present invention, the emulsifier is added in an amount of 2.0 to 6.0 parts by weight, preferably 3.0 to 4.5 parts by weight. Specifically, the content of the emulsifier may be 2.5 parts by weight, 3.5 parts by weight, 4.0 parts by weight, 5.0 parts by weight, 5.5 parts by weight, or the like.
In the present invention, the emulsifier of the present invention may be one or a combination of two or more of dimethicone and dimethicone PEG-10/15 crosspolymer, PEG-10 dimethicone, PEG/PPG-19/19 dimethicone, lauryl PEG-8 dimethicone, lauryl PEG-10 tris (trimethylsiloxy) silylethyl methicone, cetyl PEG/PPG-10/1 dimethicone, polyglycerin-4 isostearate, and the like.
In some preferred embodiments of the present invention, the emulsifier comprises a primary emulsifier and a co-emulsifier. The main emulsifier comprises polydimethylsiloxane and polydimethylsiloxane PEG-10/15 cross-linked polymer; the coemulsifier comprises PEG-10 polydimethylsiloxane. Compared with other emulsifiers such as PEG/PPG-19/19 polydimethylsiloxane and the like, the combination of the polydimethylsiloxane serving as the main emulsifier, the PEG-10/15 cross-linked polymer serving as the polydimethylsiloxane and the PEG-10 polydimethylsiloxane serving as the auxiliary emulsifier is used, so that more excellent technical effects can be achieved.
The cross-linked polymer of polydimethylsiloxane and polydimethylsiloxane PEG-10/15 is W/O type emulsifier (water-in-oil emulsifier), and the gel is prepared by mixing cross-linked organosilicon polymer (cross-linked by polyether chain) and organosilicon oil. Water-in-oil creams with high internal water phase can be prepared using dimethicone and dimethicone PEG-10/15 crosspolymer.
Furthermore, the use of the main emulsifier polydimethylsiloxane and the crosslinked polymer of the polydimethylsiloxane PEG-10/15 in combination with the auxiliary emulsifier PEG-10 polydimethylsiloxane can bring the skin with elastic texture. The emulsion system has a refreshing texture and can provide a soft skin feel. The W/O system has a waterproof effect, can form a breathable waterproof film on skin, prevents the loss of water on the surface layer of the skin and achieves the effects of water retention and water locking.
In some specific embodiments of the present invention, the amount of the primary emulsifier added is 1.5 to 4.5 parts by weight, specifically, the amount of the primary emulsifier added may be 2.0 parts by weight, 2.5 parts by weight, 3.0 parts by weight, 3.5 parts by weight, or 4.0 parts by weight, etc.; the addition amount of the co-emulsifier is 0.5-1.5 parts by weight, and the addition amount of the co-emulsifier can be 0.8 part by weight, 1.0 part by weight, 1.2 parts by weight, 1.4 parts by weight or the like.
Skin-moistening agent
In the present invention, the specific composition of the emollient is not particularly limited, and may be those commonly used in the art. In some specific embodiments of the present invention, the emollient may include one or a combination of two or more of octyldodecanol, hydrogenated polydecene, dioctyl carbonate, polydimethylsiloxane, ethylhexyl cetyl alcohol, phytosterol/octyldodecanol lauroyl glutamate, diisostearyl malate, dimethicone crosspolymer.
In some specific embodiments of the present invention, it is preferred that the emollient comprises one or a combination of two or more of octyldodecanol, hydrogenated polydecene, polydimethylsiloxane, phytosterol/octyldodecanol lauroyl glutamate, diisostearyl malate, and dimethicone crosspolymer.
In the present invention, the emollient is added in an amount of 3.0 to 18.0 parts by weight, preferably 6.0 to 15.0 parts by weight. When the addition amount of the emollient is less than 3.0 parts by weight, the moisturizing effect of the eye-lip cream of the invention is not obvious, and when the addition amount of the emollient is more than 18.0 parts by weight, the skin feel is greasy and not fresh enough. Specifically, the content of the emollient may be 4.0 parts by weight, 5.0 parts by weight, 7.0 parts by weight, 8.0 parts by weight, 9.0 parts by weight, 10.0 parts by weight, 11.0 parts by weight, 12.0 parts by weight, 13.0 parts by weight, 14.0 parts by weight, 16.0 parts by weight, 17.0 parts by weight, or the like.
Film forming agent
In some specific embodiments of the present invention, the eye lip cream further comprises a film former. In some specific embodiments of the invention, the film-forming agent comprises polyethylene.
In the invention, the polyethylene film-forming agent is added, so that the film-forming feeling can be improved, the instant tightening effect is achieved, and the effects of effectively locking water and retaining water are achieved.
In some specific embodiments of the present invention, the film forming agent is added in an amount of 0.1 to 1.0 parts by weight, preferably 0.3 to 0.7 parts by weight. When the addition amount of the film forming agent is less than 0.1 part by weight, the film forming feeling is not obvious; the addition amount of the film forming agent is more than 1.0 part by weight, and the paste is relatively thick and heavy and is not easy to coat. In order to fully exert the effect of the film forming agent, the addition amount of the film forming agent can be 0.3-0.7 part by weight. Specifically, the film-forming agent may be added in an amount of 0.2 parts by weight, 0.4 parts by weight, 0.5 parts by weight, 0.6 parts by weight, 0.8 parts by weight, or 0.9 parts by weight, or the like.
Other Components
In some specific embodiments of the present invention, the eye-lip cream further comprises: auxiliary filler, antifreeze agent, chelating agent, essence, antiseptic component, and water or a combination of more than two of the above components.
The water may be deionized water, double distilled water, ion exchange water, reverse osmosis water, purified water, etc.
The composition of the auxiliary filler in the present invention is not particularly limited, and may be any auxiliary filler commonly used in the art. For example, the auxiliary filler may be a component such as pearl powder. The pearl powder contains abundant amino acids, and has effects of instantly providing auxiliary filling fine lines, and nourishing and moisturizing skin.
In general, the amount of the auxiliary filler added may be 0 to 2 parts by weight. Specifically, the additive amount of the auxiliary filler may be 0.5 parts by weight, 1.0 parts by weight, 1.5 parts by weight, or the like.
As the antifreeze, the present invention is not particularly limited in its composition, and may be any antifreeze commonly used in the art. For example, the antifreeze agent may be magnesium sulfate or the like. Among them, magnesium sulfate is a commonly used antifreeze in water-in-oil systems.
In general, the antifreeze agent may be added in an amount of 0 to 1.5 parts by weight.
As the chelating agent, a chelating agent is a compound which contains a ligand having two or more coordinating atoms and is capable of reacting with a metal atom or ion to form a complex having a cyclic structure. Since it can react with metal ions, the product can be prevented from being turbid. And metal ions with catalytic oxidation can be inhibited to stabilize organic matters such as essence. In some specific embodiments of the present invention, the chelating agent comprises disodium EDTA and/or tetrasodium EDTA, and preferably, the chelating agent may be added in an amount of 0 to 0.5 parts by weight.
In the present invention, the preservative component means a substance that can prevent the growth of microorganisms in the product or the growth of microorganisms that react with the product.
The preservative component of the present invention is not particularly limited, and may be any preservative component commonly used in the art. Specifically, in the present invention, the preservative ingredient may include a preservative and a preservative synergist in consideration of the mildness of the product. For example, the preservative may include one or a combination of two or more of methylparaben, phenoxyethanol, chlorphenesin, and the like; the preservative synergist can comprise one or the combination of more than two of caprylyl glycol, ethylhexyl glycerin and the like. The addition amount of the antiseptic component can be 0-1 part by weight, wherein the addition amount of the antiseptic is 0-0.8 part by weight, and the addition amount of the antiseptic synergist is 0-0.2 part by weight.
< second aspect >
The present invention also provides a method for producing the lip cream according to < first aspect >, comprising a step of mixing the components of the lip cream.
In the invention, the preparation method specifically comprises the following steps:
and (3) water phase dissolving: adding the phase A into a water phase pot, heating, stirring to dissolve completely, and keeping the temperature.
Oil phase dissolving step: adding phase B into oil phase pan, heating, stirring to dissolve completely, and keeping the temperature.
Mixing: and pumping the oil phase into an emulsifying pot, slowly pumping the water phase into the emulsifying pot after the oil phase is pumped, and adding the phase C, the phase D and the optional phase E when no residual water exists after mixing to finish the preparation.
Further, in the present invention, the preparation method comprises the steps of:
and (3) water phase dissolving: adding the water phase A into a water phase pot, heating to 80-85 ℃, stirring to dissolve completely, and keeping the temperature for 10-20 min.
Oil phase dissolving step: adding the oil phase B into an oil phase pot, heating to 80-85 ℃, stirring to dissolve completely, and keeping the temperature for 5-10 min.
Mixing: pumping an oil phase into an emulsifying pot, slowly pumping a water phase into the emulsifying pot after the oil phase is pumped, stirring at a medium speed to ensure that no residual water exists after mixing, and keeping the temperature at 75-85 ℃; after the water phase is pumped out, the mixture is quickly stirred, homogenized at a high speed under stirring, and continuously stirred for cooling. Cooling to 50-55 deg.c, adding C phase, D phase and optional E phase. Then homogenizing at low speed, stopping stirring when the temperature is reduced to 30-35 ℃, and defoaming to finish the preparation.
In some embodiments of the invention, the mixing step may further include increasing the rate of drawing the aqueous phase as it is drawn 1/2 and stirring rapidly to ensure that the mass is free of residual moisture and is kept warm.
In the invention, the speed of the rapid stirring is 1000rpm-1200rpm, and the stirring time is 20min-30 min.
In the invention, the medium-speed stirring speed is 750rpm-950rpm, and the stirring time is 5min-10 min.
In the invention, the speed of the high-speed homogenization is 40-50 rpm, and the time of the high-speed homogenization is 5-10 min.
In the invention, the speed of the low-speed homogenizing is 10-20rpm, and the time of the low-speed homogenizing is 1-2 min.
In some specific embodiments of the invention, the stirring time is 5-10 min after the water phase is pumped out.
In some specific embodiments of the invention, the defoaming in the mixing step is vacuum defoaming.
In the present invention, phase a is a water-soluble component. In some specific embodiments of the invention, the water soluble component comprises a moisturizing component.
In some specific embodiments of the present invention, the water soluble component further comprises one or a combination of two or more of an auxiliary filler, an anti-freeze agent, a chelating agent, and water.
In the present invention, the B phase is an oil-soluble component.
In some specific embodiments of the present invention, the oil-soluble component comprises an emulsifier and an emollient, and additionally, the oil-soluble component may further comprise a film-forming agent.
In the present invention, the C phase is a filler component.
In the present invention, the D phase is a repair component.
In the present invention, the phase E is a perfume, and/or a preservative component.
Examples
Embodiments of the present invention will be described in detail below with reference to examples, but those skilled in the art will appreciate that the following examples are only illustrative of the present invention and should not be construed as limiting the scope of the present invention. The examples, in which specific conditions are not specified, were conducted under conventional conditions or conditions recommended by the manufacturer. The reagents or instruments used are not indicated by the manufacturer, and are all conventional products commercially available.
VISIA-CR apparatus: the manufacturer: canfield corporation, USA; the model is as follows: VISIA-CR skin tester;
skin moisture tester: the manufacturer: CK company, Germany; the model is as follows: CM 825-MDD;
macromolecular sodium hyaluronate: number average molecular weight: 600kDa to 800 kDa;
small molecule sodium hyaluronate: number average molecular weight: 3000Da to 10000 Da.
Examples 1 to 10
Lip creams of examples 1-10 were prepared according to the following method, based on the parts by weight of the components of examples 1-10 in tables 1, 4 and 7 below.
(1) Adding the water phase A into a water phase pot, heating to 80-85 deg.C, stirring to dissolve completely, and maintaining the temperature for 15 min.
(2) Adding oil phase B into oil phase pan, heating to 80-85 deg.C, stirring to dissolve completely, and keeping the temperature for 10 min.
(3) Pumping an oil phase into an emulsifying pot, slowly pumping a water phase into the emulsifying pot after the oil phase is pumped, stirring at a medium speed of 800rpm, and ensuring that no residual water exists in a material body; when the water phase is pumped to 1/2, the speed of pumping the water phase can be increased, and the water phase is rapidly stirred at the stirring speed of 1000rpm to ensure that the material body has no residual moisture, and the temperature is kept at 80 +/-5 ℃; after the water phase is pumped out, continuing stirring for 5min, then homogenizing at a high speed of 1000rpm for 8min, and continuing stirring and cooling at a homogenizing speed of 40 rpm; adding the rest C, D, E phase at 50 deg.C, homogenizing at low speed for 1min, and homogenizing at 15 rpm; after stirring uniformly, stopping stirring at 35 ℃, and defoaming in vacuum to finish the preparation.
Comparative example 1
Lip cream of comparative example 1 was prepared according to the parts by weight of the components of comparative example 1 in the following table 1 and in the same manner as in examples 1 to 10.
TABLE 1
Comparison of instant filling Fine lines effects of comparative example 1 and examples 1-3
The method comprises the following steps: 48 qualified volunteers (12 in each group) were selected by volunteer screening as subjects to participate in the test. The visual evaluation was carried out by observing and evaluating the external canthus wrinkles and lip wrinkles according to the evaluation criteria, and after visual observation of the original values, the subjects were scored with 0.5g of the lip creams of comparative example 1 and examples 1 to 3, respectively, and the visual test values after 5 min. The evaluation basis of the scores is classified into 7 grades, the score grades are shown in table 2, and the test results are shown in table 3, wherein the values in table 3 are average values obtained after the 12 persons in each group are comprehensively scored.
TABLE 2
TABLE 3
As can be seen from table 3: (1) as can be seen from comparative example 1 and examples 1 to 3, the lip creams of examples 1 to 3 according to the present invention have a remarkable effect of instantly filling the lip marks.
(2) In the periocular region, the sample application region periocular fine lines showed greater and greater differences in immediate filling effects for external canthus wrinkles after using the samples of examples 1 to 3, and it was confirmed that the immediate filling effects for periocular wrinkles became better and better with increasing content of HDI/trimethylolhexyl lactone crosspolymer, which is a filling component, in the range of the present invention.
(3) Lip region, sample application region lip skin fine lines the differences in the instant filling effect of the lip lines after the use of the samples of examples 1 to 3 were larger and larger, and it was confirmed that the instant filling effect of the lip lines was better and better as the content of the HDI/trimethylol hexyl lactone crosslinked polymer as the filling component was increased within the content range of the present invention.
TABLE 4
Comparison of Long-lasting Fine line fading effects of examples 4 to 7
The method comprises the following steps: 48 qualified volunteers (12 in each group) were selected by volunteer screening as subjects to participate in the test. Visual evaluation was performed by observing and evaluating canthus wrinkles and lip and lip wrinkles according to evaluation criteria, and taking the evaluation of anti-wrinkle efficacy for a 56 day cycle as an example, the subject needed to take two tests, facial imaging collection and dermatologist clinical evaluation, before using the test sample (D0), 0.5g of the test sample per day, and after 56 days of use (D56) for 2 time points. The visual evaluation was carried out by observing and evaluating the external canthus wrinkle part and lip wrinkles according to the evaluation criteria, and the photograph evaluation was carried out by observing and evaluating the external canthus fine lines and lip wrinkles photograph taken by VISIA-CR according to the same criteria. The evaluation basis of the comprehensive score is classified into 7 grades, the specific score standard is shown in table 5, and the test result is shown in table 6, wherein the value in table 6 is the average value obtained after the comprehensive score of 12 persons in each group.
TABLE 5
TABLE 6
As can be seen from table 6: (1) the labial veins of examples 4-7 of the present invention have a certain long-lasting fine line fading effect both in the periocular region and in the lip region.
(2) Periocular region: skin fine lines around eyes of sample application area after using the lip creams of the eyes of examples 4 to 7, the difference of the external periocular wrinkle reduction effects of examples 6 to 7 was greater than those of examples 4 to 5, demonstrating that the external periocular wrinkle reduction effects of examples 6 to 7 were better than those of examples 4 to 5 after 56 days.
(3) Lip line area: lip skin fine lines in sample application areas after the eye lip cream of examples 4-7 was used, the lip line lightening effect difference of examples 6-7 was greater than that of examples 4-5, and it was confirmed that the lip line lightening effect was good for a long period after gamma-aminobutyric acid and dipalmitoyl hydroxyproline were added.
TABLE 7
Comparison of moisturizing Effect of examples 6, 8 to 10
The method comprises the following steps: 40 qualified volunteers (10 per group) were selected by volunteer screening as subjects to participate in the test. The subjects cleaned the eyes and lips with the basic cleanser, dried, and then tested the initial value of skin epidermal moisture with the skin moisture tester, and then tested the skin epidermal moisture of each part with the skin moisture tester using 0.5g of each of the samples of example 6 and examples 8 to 10 for 6 hours, and the average value of the skin moisture content is shown in table 8, wherein the higher the value, the better the moisturizing performance is.
TABLE 8
As can be seen from table 8, (1) example 6 and examples 8 to 10 of the present invention all had a certain moisturizing effect.
(2) The test data show that the moisture content value of the female volunteers is higher than that of the samples of examples 8 and 9 after the samples of examples 6 and 10 are used, so that the combination of the macromolecular sodium hyaluronate and the small-molecular sodium hyaluronate can generate a synergistic effect and has more excellent moisturizing effect.
Having described embodiments of the present disclosure, the foregoing description is intended to be exemplary, not exhaustive, and not limited to the disclosed embodiments. Many modifications and variations will be apparent to those of ordinary skill in the art without departing from the scope and spirit of the described embodiments. The terminology used herein is chosen in order to best explain the principles of the embodiments, the practical application, or improvements made to the technology in the marketplace, or to enable others of ordinary skill in the art to understand the embodiments disclosed herein.
Industrial applicability
The eye-lip cream and the preparation method thereof can be industrially implemented.
Claims (10)
1. An eye lip cream, which is characterized by comprising the following components:
emulsifier: 2.0 to 6.0 parts by weight, preferably 3.0 to 4.5 parts by weight;
and (3) an emollient: 3.0 to 18.0 parts by weight, preferably 6.0 to 15.0 parts by weight;
moisture retention component: 5.0 to 15.0 parts by weight, preferably 7.0 to 12.0 parts by weight;
filling components: 1.0 to 5.0 parts by weight, preferably 1.5 to 4.5 parts by weight;
repairing components: 0.05 to 5.0 parts by weight, preferably 0.1 to 4.0 parts by weight; wherein,
the filling component comprises HDI/trihydroxymethyl hexyl lactone cross-linked polymer;
the repairing component comprises one or the combination of more than two of hydroxyproline or derivatives thereof and gamma-aminobutyric acid.
2. The lip cream of claim 1, wherein the repair composition comprises hydroxyproline or derivatives thereof and gamma-aminobutyric acid; preferably, the first and second electrodes are formed of a metal,
the addition amount of the hydroxyproline or the derivatives thereof is 0.95-4.95 parts by weight, preferably 1.9-3.9 parts by weight;
the addition amount of the gamma-aminobutyric acid is 0.05 to 0.5 part by weight, preferably 0.1 to 0.3 part by weight.
3. The eye lip cream according to claim 2, wherein the hydroxyproline or derivative thereof comprises dipalmitoyl hydroxyproline.
4. The eye lip cream according to any one of claims 1 to 3, wherein the moisturizing component comprises small-molecule sodium hyaluronate or/and large-molecule sodium hyaluronate, the small-molecule sodium hyaluronate is added in an amount of 0.01 to 0.3 parts by weight, and the large-molecule sodium hyaluronate is added in an amount of 0.01 to 0.2 parts by weight; wherein,
the number average molecular weight of the micromolecular sodium hyaluronate is 3000 Da-10000 Da,
the number average molecular weight of the macromolecular sodium hyaluronate is more than 10kDa to 1000 kDa.
5. The eye-lip cream according to any one of claims 1 to 4, wherein the emulsifier comprises a primary emulsifier and a co-emulsifier; wherein,
the addition amount of the main emulsifier is 1.5-4.5 parts by weight; the addition amount of the co-emulsifier is 0.5-1.5 parts by weight; preferably, the first and second electrodes are formed of a metal,
the main emulsifier comprises polydimethylsiloxane and polydimethylsiloxane PEG-10/15 cross-linked polymer;
the coemulsifier comprises PEG-10 polydimethylsiloxane.
6. The eye lip cream according to any one of claims 1 to 5, wherein the emollient comprises one or a combination of two or more of octyldodecanol, hydrogenated polydecene, dioctyl carbonate, polydimethylsiloxane, ethylhexyl cetyl alcohol, phytosterol/octyldodecanol lauroyl glutamate, diisostearyl malate, and dimethicone crosspolymer.
7. The eye lip cream according to any one of claims 4 to 6, wherein the moisturizing component further comprises one or a combination of two or more of glycerin, propylene glycol, butylene glycol, oat glucan, glyceryl polyether-26, xylitol-based glucoside/anhydroxylitol/xylitol.
8. The eye lip cream according to any one of claims 1 to 7, wherein the eye lip cream further comprises a film forming agent; preferably, the addition amount of the film forming agent is 0.1-1.0 part by weight, preferably 0.3-0.7 part by weight;
more preferably, the film former comprises polyethylene.
9. The eye lip cream according to any one of claims 1 to 8, wherein the eye lip cream further comprises one or a combination of more than two of auxiliary fillers, antifreeze agents, chelating agents, fragrances and preservative components.
10. A method of preparing an eye lip cream according to any one of claims 1 to 9, comprising the step of mixing the components of the eye lip cream.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910865853.4A CN110464666A (en) | 2019-09-12 | 2019-09-12 | Eye lip frost and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910865853.4A CN110464666A (en) | 2019-09-12 | 2019-09-12 | Eye lip frost and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN110464666A true CN110464666A (en) | 2019-11-19 |
Family
ID=68514052
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910865853.4A Pending CN110464666A (en) | 2019-09-12 | 2019-09-12 | Eye lip frost and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN110464666A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113440442A (en) * | 2020-08-04 | 2021-09-28 | 长沙黛西生物科技有限公司 | Composition and cosmetic composition for resisting wrinkle, resisting inflammation and keeping moisture of skin, lipstick and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107115220A (en) * | 2017-05-22 | 2017-09-01 | 深圳博诗尼澳生物科技有限公司 | A kind of activity of fighting against senium compositions and preparation method and application |
-
2019
- 2019-09-12 CN CN201910865853.4A patent/CN110464666A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107115220A (en) * | 2017-05-22 | 2017-09-01 | 深圳博诗尼澳生物科技有限公司 | A kind of activity of fighting against senium compositions and preparation method and application |
Non-Patent Citations (1)
| Title |
|---|
| PHOTEK: "SkinMedica TNS Line Refine", 《HTTP://WWW.COSDNA.COM/CHS/COSMETIC_2D7748595.HTML》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113440442A (en) * | 2020-08-04 | 2021-09-28 | 长沙黛西生物科技有限公司 | Composition and cosmetic composition for resisting wrinkle, resisting inflammation and keeping moisture of skin, lipstick and preparation method thereof |
| CN113440442B (en) * | 2020-08-04 | 2022-09-20 | 长沙黛西生物科技有限公司 | Composition and cosmetic composition for resisting wrinkle, resisting inflammation and keeping moisture of skin, lipstick and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP6843863B2 (en) | Compositions containing at least two fatty acid esters of (poly) glycerol, and their use in cosmetics | |
| JP5143354B2 (en) | Oligomer ester and cosmetics and skin external preparations containing these | |
| JPWO2004071472A1 (en) | External preparation for skin comprising a carbohydrate derivative of α, α-trehalose | |
| EP3886790B1 (en) | Composition comprising hectorite and pectin | |
| JP2019006725A (en) | Hyaluronic acid production promoter and cosmetics containing the same | |
| JP2007045776A (en) | Humectant and cosmetic and skin care preparation for external use by using the same | |
| KR20150095607A (en) | Oil-in-water emulsion composition | |
| CN110934763A (en) | Skin care composition for moisturizing | |
| CN110664644A (en) | Skin care composition containing folic acid, essence and preparation method thereof | |
| WO2019013670A1 (en) | Cosmetic mask for application to the skin, and method for applying same | |
| JP3922311B2 (en) | Skin aging prevention cosmetics | |
| JP5025254B2 (en) | Cosmetic preparations and cosmetics for improving the skin groove density | |
| JP2015034131A (en) | Fermented fig extract, method for producing the same, and cosmetic in which fermented fig extract is blended | |
| JP2011246372A (en) | Beauty set for improving symptom of aging of skin of neck, and beauty method using the same | |
| JPH10279466A (en) | Preparation for external use | |
| JP7039178B2 (en) | Topical composition containing crosslinked glycosaminoglycan | |
| JP2001131049A (en) | Skin preparation for external use | |
| CN110464666A (en) | Eye lip frost and preparation method thereof | |
| JPS63150209A (en) | Skin cosmetic | |
| CN112274456A (en) | Multiple moisturizing composition and application thereof | |
| JP2022516011A (en) | Compositions containing polysaccharides, polyols and certain esters | |
| RU2456977C1 (en) | Dry and very dry skin care preparation | |
| CN115737456A (en) | Skin cleaning scrub cream and preparation method thereof | |
| JP4548831B2 (en) | Hydrogenated retinoid or hydrogenated retinoid derivative and use thereof | |
| JP2004075635A (en) | Moisturizing agent and external preparation for skin |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20191119 |