CN110327115A - A kind of optical coherent chromatographic imaging operation piloting method - Google Patents
A kind of optical coherent chromatographic imaging operation piloting method Download PDFInfo
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- 238000000034 method Methods 0.000 title claims abstract description 22
- 238000003384 imaging method Methods 0.000 title claims description 15
- 230000003287 optical effect Effects 0.000 title claims description 11
- 230000001427 coherent effect Effects 0.000 title claims 7
- 238000012014 optical coherence tomography Methods 0.000 claims abstract description 24
- 239000000523 sample Substances 0.000 claims abstract description 21
- 239000000835 fiber Substances 0.000 claims abstract description 16
- 239000013307 optical fiber Substances 0.000 claims abstract description 9
- 238000012545 processing Methods 0.000 claims abstract description 3
- NIXOWILDQLNWCW-UHFFFAOYSA-N acrylic acid group Chemical group C(C=C)(=O)O NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 4
- 238000004458 analytical method Methods 0.000 claims description 2
- 238000001514 detection method Methods 0.000 abstract description 4
- 230000008878 coupling Effects 0.000 abstract description 2
- 238000010168 coupling process Methods 0.000 abstract description 2
- 238000005859 coupling reaction Methods 0.000 abstract description 2
- 238000003325 tomography Methods 0.000 abstract description 2
- 210000001519 tissue Anatomy 0.000 description 12
- 238000004364 calculation method Methods 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
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- 238000002406 microsurgery Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
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- A61B34/00—Computer-aided surgery; Manipulators or robots specially adapted for use in surgery
- A61B34/20—Surgical navigation systems; Devices for tracking or guiding surgical instruments, e.g. for frameless stereotaxis
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- A61B5/0066—Optical coherence imaging
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- A—HUMAN NECESSITIES
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- A61B34/00—Computer-aided surgery; Manipulators or robots specially adapted for use in surgery
- A61B34/20—Surgical navigation systems; Devices for tracking or guiding surgical instruments, e.g. for frameless stereotaxis
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Abstract
本发明提供一种光学相干层析成像手术导航方法，具体过程是扫频激光器发射出1310nm的激光束，经过隔离器、光纤耦合(90:10)后，激光束分成两束激光，分别为参考光和样品光：参考光经过环形器进入参考臂后，经过准直器准直，在凸透镜聚焦在平面反射镜上，返回的光经过环形器到达光纤耦合器(50:50)；样品光经环形器进入样品臂，经过光纤进入与手术刀集成的光学相干层析成像扫描探头中实现对手术部位组织的探测，同时获得的背向散射光与参考光在光纤耦合器中产生干涉由平衡探测器采集干涉信号，数据采集处理系统得层析成像。本发明的优点是：将光学相干层析成像系统的扫描装置与手术刀进行集成化，实现对手术实施部位的精确探测为手术实施提供精确指导。
The invention provides an optical coherence tomography surgical navigation method. The specific process is that a swept-frequency laser emits a 1310nm laser beam, and after passing through an isolator and optical fiber coupling (90:10), the laser beam is divided into two laser beams, which are respectively a reference Light and sample light: After the reference light enters the reference arm through the circulator, it is collimated by the collimator, focused on the plane mirror by the convex lens, and the returned light passes through the circulator to the fiber coupler (50:50); The circulator enters the sample arm and enters the optical coherence tomography scanning probe integrated with the scalpel through the optical fiber to realize the detection of the surgical site tissue. The device collects interference signals, and the data acquisition and processing system obtains tomography. The advantages of the invention are that the scanning device of the optical coherence tomography system is integrated with the scalpel, so as to realize the accurate detection of the operation site and provide precise guidance for the operation.
Description
技术领域technical field
本发明涉及一种光学探测集成系统，具体为一种光学相干层析成像手术导航方法。The invention relates to an optical detection integrated system, in particular to an optical coherence tomography surgical navigation method.
背景技术Background technique
生物组织表皮下的物质和结构是研究的主要对象，通过光学相干层析成像系统对组织进行无损成像获得组织相关组成。用于检测身体内部组织的大型成像系统，如核磁共振成像能够对手术部位进行固定位置成像，但对于手术部位组织后物质无法实现实时成像。The substances and structures under the epidermis of biological tissues are the main objects of research, and tissue-related compositions are obtained by non-destructive imaging of tissues by optical coherence tomography systems. Large-scale imaging systems used to detect internal body tissue, such as MRI, can image the surgical site in a fixed position, but cannot achieve real-time imaging of the material behind the surgical site.
当前体内微型手术只能通过内窥的方式进行手术，但是在内窥手术过程中，无法实现对于手术刀切割部位的组织状态及组织结构进行探测分析。At present, micro-surgery in vivo can only be performed by means of endoscopy, but during the endoscopic operation, it is impossible to detect and analyze the tissue state and tissue structure of the cutting site of the scalpel.
发明内容SUMMARY OF THE INVENTION
本发明的目的在于提供一种光学相干层析成像手术导航装置,本发明的思想在与创新性的将光学相干层析成像系统的扫描探头与手术刀具集成，为手术切割进行指导，确保手术的安全性和可靠性。The purpose of the present invention is to provide an optical coherence tomography surgical navigation device. The idea of the present invention is to integrate the scanning probe of the optical coherence tomography system with the surgical tool innovatively, so as to guide the surgical cutting and ensure the operation safety. Safety and reliability.
一种光学相干层析成像手术导航方法,对应装置包括扫频激光器、隔离器、光纤耦合器(90:10)、环形器、准直器、聚焦透镜、平面反射镜、二维微机电扫描振镜、自聚焦透镜、亚克力反射透镜组合套件、光纤耦合器(50:50)、平衡探测器、集成扫描探头的手术刀、12位信号采集系统。装置的具体过程是扫频激光器发射出1310nm的激光束通过光纤传递经隔离器、光纤耦合(90:10)后，激光束分成两束激光，分别为参考光和样品光：参考光经过环形器进入参考臂后，经过准直器准直，在凸透镜聚焦在平面反射镜上，返回的光经过环形器到达光纤耦合器(50:50)；样品光经环形器进入样品臂，经过光纤进入与手术刀集成的光学相干层析成像扫描探头扫描手术部位组织，同时获得的背向散射光与参考光在光纤耦合器中产生干涉由平衡探测器采集干涉信号，经过12位数据采集处理系统分析获得层析成像。An optical coherence tomography surgical navigation method, the corresponding device includes a frequency sweep laser, an isolator, an optical fiber coupler (90:10), a circulator, a collimator, a focusing lens, a plane mirror, and a two-dimensional microelectromechanical scanning oscillator. Mirror, self-focusing lens, acrylic reflecting lens combination kit, fiber optic coupler (50:50), balanced detector, scalpel with integrated scanning probe, 12-bit signal acquisition system. The specific process of the device is that the 1310nm laser beam emitted by the swept frequency laser is transmitted through the optical fiber through the isolator and optical fiber coupling (90:10), and the laser beam is divided into two laser beams, namely the reference light and the sample light: the reference light passes through the circulator. After entering the reference arm, it is collimated by the collimator, focused on the plane mirror by the convex lens, and the returned light passes through the circulator to the fiber coupler (50:50); the sample light enters the sample arm through the circulator, and enters the The optical coherence tomography scanning probe integrated in the scalpel scans the tissue at the surgical site, and the obtained backscattered light and the reference light interfere in the fiber coupler. tomography.
本发明涉及一种光学相干层析成像手术导航方法，其特点是将光学相干层析成像系统的扫描装置集成在探头中。The invention relates to an optical coherence tomography surgical navigation method, which is characterized in that a scanning device of an optical coherence tomography system is integrated in a probe.
本发明涉及一种光学相干层析成像手术导航方法，其特点是光学相干层析成像系统内窥探头封装的尺寸为2mm×3mm。The invention relates to an optical coherence tomography surgical navigation method.
本发明涉及一种光学相干层析成像手术导航方法，其特点是光学相干层析成像系统扫描探头使用自聚焦透镜、二维微机电扫描振镜(MEMS)和亚克力反射透镜。The invention relates to an optical coherence tomography surgical navigation method.
本发明的优点在于：光学相干层析成像技术可以对组织进行深度成像，获得组织表层下信息，精确的指导手术操作,主要是将光学相干层析成像系统的扫描探头与手术刀进行集成，用于探测手术刀尖前的组织状况，为医生手术提供导航作用。The advantages of the present invention lie in that: the optical coherence tomography technology can perform deep imaging on the tissue, obtain the subsurface information of the tissue, and accurately guide the surgical operation, mainly integrating the scanning probe of the optical coherence tomography system with the scalpel, It is used to detect the tissue condition in front of the scalpel tip and provide navigation for doctors to operate.
附图说明Description of drawings
图1是本发明的系统原理图。Fig. 1 is the system principle diagram of the present invention.
图1所示：1310nm扫频激光器(01)、90:10光纤耦合器(02)、光纤环形器(03)、准直器(04)、凸透镜(05)、反射镜(06)、自聚焦透镜(07)、二维微电机扫描振镜(08)、亚克力反射透镜组(08)、集成探头手术刀(10)、As shown in Figure 1: 1310nm frequency sweep laser (01), 90:10 fiber coupler (02), fiber circulator (03), collimator (04), convex lens (05), mirror (06), self-focusing Lens (07), two-dimensional micro-motor scanning galvanometer (08), acrylic reflective lens group (08), integrated probe scalpel (10),
50:50光纤耦合器(11)、光电平衡探测器(12)、12位数据采集系统(13)。A 50:50 fiber coupler (11), a photoelectric balance detector (12), and a 12-bit data acquisition system (13).
具体实施方式Detailed ways
一种光学相干层析成像手术导航方法，具体过程是1310nm扫频激光器01发射出激光束通过光纤经90:10的光纤耦合器02分成样品光和参考光，其中参考光经光纤环形器03、准直镜04、凸透镜05到平面反射镜06产生反射光通过光纤回到50:50的光纤耦合器09；样品光通过光纤传递经光纤环形器03、自聚焦透镜07、二维微电机扫描振镜08、亚克力反射透镜组09后进入探测组织，同时组织产生的背向散射光经过原光路回到光纤耦合器11中与参考光产生干涉，干涉光信号经过光电平衡探测器12转换成电信号，在12位数据采集卡13中经过计算、分析处理实现模数转换生成层析图像，为手术实施提供精准指导。An optical coherence tomography surgical navigation method, the specific process is that a 1310nm frequency sweep laser 01 emits a laser beam through an optical fiber and is divided into a sample light and a reference light by a 90:10 fiber coupler 02, wherein the reference light is passed through the fiber circulator 03, The collimating mirror 04, convex lens 05 and plane mirror 06 generate reflected light back to the fiber coupler 09 of 50:50 through the optical fiber; The mirror 08 and the acrylic reflective lens group 09 enter the detection tissue, and the backscattered light generated by the tissue returns to the fiber coupler 11 through the original optical path to interfere with the reference light, and the interference light signal is converted into an electrical signal through the photoelectric balance detector 12 , in the 12-bit data acquisition card 13 through calculation, analysis and processing to achieve analog-to-digital conversion to generate tomographic images, to provide accurate guidance for the implementation of surgery.
本发明涉及一种光学相干层析成像手术导航方法，其特点是将光学相干层析成像系统的样品臂通过光纤与手术刀结合进行集成，实现手术过程中对手术部位进行检查。The invention relates to an optical coherence tomography surgical navigation method, which is characterized in that the sample arm of the optical coherence tomography system is integrated with a scalpel through an optical fiber, so as to realize the inspection of the surgical site during the operation.
本发明涉及一种光学相干层析成像手术导航方法，其特点是将光学相干层析成像系统的扫描装置集成在探头中。The invention relates to an optical coherence tomography surgical navigation method, which is characterized in that a scanning device of an optical coherence tomography system is integrated in a probe.
本发明涉及一种光学相干层析成像手术导航方法，其特点是光学相干层析成像系统内窥探头封装的尺寸为2mm×3mm。The invention relates to an optical coherence tomography surgical navigation method.
本发明涉及一种光学相干层析成像手术导航方法，其特点是光学相干层析成像系统扫描探头使用自聚焦透镜、二维微机电扫描振镜(MEMS)和亚克力反射透镜。The invention relates to an optical coherence tomography surgical navigation method.
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Cited By (3)
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| CN110623645A (en) * | 2019-10-18 | 2019-12-31 | 南昌航空大学 | An integrated device for optical coherence tomography and photoacoustic imaging |
| CN110987874A (en) * | 2019-11-29 | 2020-04-10 | 南昌航空大学 | Optical coherence tomography system based on quantum dot semiconductor amplifier |
| CN111528799A (en) * | 2020-04-28 | 2020-08-14 | 中山大学 | Method for improving dynamic range of sweep frequency light source optical coherence tomography system |
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