CN110314292A - It is used to form the device and method of specified radiation therapy treatment instruction - Google Patents
It is used to form the device and method of specified radiation therapy treatment instruction Download PDFInfo
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- 238000000034 method Methods 0.000 title claims description 43
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- 238000005457 optimization Methods 0.000 claims abstract description 19
- 230000004044 response Effects 0.000 claims abstract description 13
- 238000012913 prioritisation Methods 0.000 claims abstract description 4
- 230000005855 radiation Effects 0.000 claims description 62
- 230000000007 visual effect Effects 0.000 claims description 6
- 238000011156 evaluation Methods 0.000 claims description 5
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/103—Treatment planning systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/103—Treatment planning systems
- A61N5/1031—Treatment planning systems using a specific method of dose optimization
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/103—Treatment planning systems
- A61N5/1038—Treatment planning systems taking into account previously administered plans applied to the same patient, i.e. adaptive radiotherapy
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- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H10/00—ICT specially adapted for the handling or processing of patient-related medical or healthcare data
- G16H10/60—ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records
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- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H20/00—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance
- G16H20/40—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to mechanical, radiation or invasive therapies, e.g. surgery, laser therapy, dialysis or acupuncture
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/1048—Monitoring, verifying, controlling systems and methods
- A61N2005/1074—Details of the control system, e.g. user interfaces
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- General Health & Medical Sciences (AREA)
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Abstract
Prescription user can specify clinical target and distinguish the order of priority of clinical target, this may be used as the basis of optimization purpose again to instruct the planning to radiotherapy treatment planning.Then the prescription user can change the order of priority of one or more clinical targets, and the information of the variation about the dosage distribution based on fluence occurred in response to the variation of those of relative prioritization between the clinical target is checked, to understand the dosage tradeoff of the order of priority corresponded between the clinical target.
Description
Technical field
These introductions relate generally to the formation and application of radiotherapeutic treatment plan, and relate more specifically to be formed with it is excellent
Change the order of priority for the clinical target that treatment plan is based on.
Background technique
It the use of radiotherapy medical conditions include the known art that the prior art is made great efforts.For example, radiotherapy includes being used for
Reduce or eliminate the important component of many treatment plans of undesired tumour.Unfortunately, radiation applied itself is no
It is required or even crucial adjacent tissue, organ etc. that undesired substance, which is distinguished, with the survival that continues for patient.
Therefore, usually apply radiation in a manner of carefully applying, be restricted to given target volume at least attempt to radiate.
Treatment plan be typically used in it is specified with it is this for given patient's application when using specific radiotherapy platform
Treat related any amount of operating parameter.For example, many treatment plans are provided for being exposed to target volume from many
The radiation of the possibility various dose of different directions.For example, arc therapy includes a kind of such method.
These treatment plans usually optimize before the use.It will be understood that as used herein expression " optimization ",
" optimised " and " in optimization " should not be better than the theory phase of objective " best " plan of all other possible plan with identification
Obscure.On the contrary, this optimization includes iteratively evaluation to the alternative solution worked out a scheme, with typically identify it is a series of continuously more
Good plan.This may include the iteration change for each of for example attempting and assess aforementioned operation parameter (or many).Make
For specific example in these areas, when optimizing radiotherapy treatment planning relative to multi-diaphragm collimator, optimization process is typically logical
Cross the optimum position for testing various such positions iteratively to seek each leaf pair, and with all other leaf to it is unrelated (for
Each exposure field).
Many treatment plan optimisation techniques, such as so-called Inverse Planning, need to set optimization purpose.Optimize purpose to provide
A kind of measure, by the measure, which can test or ensure equably to apply specific finger in the target volume of patient
Determine dosage, while avoiding that the excessive of other patient tissues is administered (alternatively, in other cases, satisfaction is specified in target volume
With a series of dose histograms of the acceptable dosage range of the various positions outside target volume).
Therefore, optimization purpose will be understood as being designed specifically for very much reflecting and adapting to specific radiotherapy platform
Technical detail and specification, about patient performance detail and/or with specific application set related other physical details
Purpose.These details generally are regarded as in the special of originally people's (that is, for example, having the oncologist of license) of specified radiotherapy
Except industry knowledge and rudimentary knowledge.It is therefore intended that the people of radiotherapy will not generally also generate optimization purpose.
On the contrary, the people of prescription specifies clinical radiotherapy target.These clinical targets are generally set with relative to specific application
Fixed (including radiotherapy platform itself) unknowable saying is expressed.For example, prescription user can specify various treatment bodies
Product (that is, the tissue being targeted, such as tumour) and the so-called of minimum is jeopardized into the specific of organ for its radiating irradiation
Minimum or maximum dose.
In the typical case, it is understood that there may be multiple clinical radiotherapy targets also can permit place in this case
Square user establishes the relative priority between these targets.Unfortunately, although prescription user may understand this in a general sense
How the priority of a little targets will influence the formation of corresponding radiotherapy treatment planning, but this understanding will be generally inherently phase
To general.Therefore, which kind of dosage tradeoff prescription user, which will typically be unable to better understand and can correspond to various radiation, is controlled
Treat the certain priority selection between clinical target.
Detailed description of the invention
By provide the equipment for being used to form specified radiation therapy treatment instruction described in the following detailed description and
Method at least partly meets the above needs, especially when being studied in conjunction with attached drawing, in which:
Fig. 1 includes the block diagram according to the various embodiments configuration of these introductions；
Fig. 2 includes the flow chart according to the various embodiments configuration of these introductions；
Fig. 3 includes the partial screenshot according to the various embodiments configuration of these introductions；
Fig. 4 includes the flow chart according to the various embodiments configuration of these introductions；And
Fig. 5 includes the partial screenshot according to the various embodiments configuration of these introductions.
Element in attached drawing is succinct and understands and show, and is not drawn necessarily to scale.For example, the element in attached drawing
In some sizes and/or relative positioning may be exaggerated relative to other elements, with help promote to the various of this introduction
The understanding of embodiment.In addition, useful in commercially viable embodiment or necessary common but Yi Li is usually not shown
The element of solution, to check these various embodiments of this introduction convenient for less obstruction.Certain movements and/or step can be with
It describes or shows with specific order of occurrence, and it will be apparent to one skilled in the art that not needing actually this about sequence
Specificity.Unless elaborated different concrete meanings herein, otherwise terms used herein and expression have with such as
The consistent ordinary skill meaning that those skilled in the art of upper elaboration assign these terms and expressions.
Specific embodiment
In general, the specified treatment that these various embodiments are used to form the radiotherapy for particular patient refers to
It enables.Specified treatment instruction is configurable for determining excellent to create for being optimized using the radiotherapy treatment planning of automatically iteration
The corresponding radiotherapy treatment planning of the radiotherapy treatment planning of change optimizes purpose.These introductions are provided using user interface and can be grasped
Make the control circuit that ground is coupled to the user interface.
These introductions provide is presented multiple clinical radiotherapy targets on a user interface, multiple clinical radiotherapy mesh
Mark has the original state relative priority established by prescription user between them.By a kind of method, above-mentioned relative priority
Grade is able to establish and be indicated by the relative position of target relative to each other.These introductions will be essentially adapted to any amount of put
Penetrate treatment clinical target.
Then, these introductions provide for according to multiple clinical radiotherapy targets and multiple clinical radiotherapy targets it
Between relative priority determine the first radiation dose distribution based on fluence of particular patient, and present about particular patient
The first radiation dose distribution based on fluence information.It then can will be about the phase between multiple clinical radiotherapy targets
The information of corresponding first radiation dose distribution based on fluence of priority and particular patient is automatically saved as corresponding
First state.By a kind of method, the information saved includes fluence information, but does not include corresponding calculated dosage distribution
As a result.
When then prescription user changes the relative priority between multiple clinical radiotherapy targets, these introductions are provided
It is moved for the relative priority according to the change between multiple clinical radiotherapy targets and multiple clinical radiotherapy targets
Determine to state the second radiation dose distribution based on fluence of particular patient.By a kind of method, prescription user passes through in user
It selects to control with the given one in kineradiotherapy clinical target in order to change the target relative to other radiation on interface
The relative position of one or more of clinical target is treated to change relative priority.
Then the information of the second radiation dose distribution based on fluence about particular patient is presented.It then will be about multiple
The relative priority of change between clinical radiotherapy target and the corresponding second radiological agent based on fluence of particular patient
The information of amount distribution automatically saves as corresponding second state.
By a kind of method, aforementioned active is at least partially based on the use of first group of rule, first group of rule foundation
Relative priority between multiple clinical radiotherapy targets and multiple clinical radiotherapy targets limits putting based on fluence
Penetrate dosage distribution.In addition, above-mentioned activity can be at least partially based on the use of second group of rule, second group of rule is according to inspection
It measures the variation of the relative priority between multiple clinical radiotherapy targets and specified automatically save the multiple radiation and control
The information of the relative priority and the corresponding radiation dose distribution based on fluence between clinical target is treated as corresponding state.
Therefore, as an illustrated example, the patient that these introductions can provide for formulating for radiotherapy controls
Prescription instruction is treated, the specified treatment instruction is arranged to determine by providing user interface for creating optimization
The corresponding radiotherapy treatment planning of radiotherapy treatment planning optimizes purpose, and multiple clinical radiotherapies are presented on a user interface
Target, multiple clinical radiotherapy targets have original state relative priority between them.This method is then according to multiple
Original state relative priority between clinical radiotherapy target and multiple clinical radiotherapy targets determines the of patient
One radiation dose distribution based on fluence, and the information of the first radiation dose distribution based on fluence about patient is presented.
In the method, corresponding about relative priority and patient between multiple clinical radiotherapy targets is automatically saved
The information of one radiation dose distribution based on fluence is as corresponding first state.
In response to changing the relative priority between multiple clinical radiotherapy targets via user interface, these religions
Leading can be provided for according to the opposite of the change between multiple clinical radiotherapy targets and multiple clinical radiotherapy targets
Priority dynamically determines the second radiation dose distribution based on fluence of patient, and presents and be based on about the second of patient
The information of the radiation dose distribution of fluence then automatically saves the phase about the change between multiple clinical radiotherapy targets
To the information of the corresponding second radiation dose distribution based on fluence of priority and particular patient as corresponding second state.
In this example, it then shows on a user interface about in response to the phase between multiple clinical radiotherapy targets
The visual information of the variation for the dosage distributed intelligence based on fluence that the variation of order of priority occurs, corresponds to show
The dosage of order of priority between radiotherapy clinical radiotherapy target is weighed.
By a kind of method, multiple radiotherapies with relative priority between them are presented on a user interface and face
Bed target includes that clinical radiotherapy target is presented with presentation sequence, wherein the phase of the specific one in clinical radiotherapy target
The relative priority of the specific one in clinical radiotherapy target is established to position.
By a kind of method, user passes through selection on a user interface and mobile (for example, by being clicking and dragging on) radiation
It is opposite between multiple clinical radiotherapy targets to select to sexually revise to treat the relative position of at least one of clinical target
Priority.
These introductions are very flexible in practice, and will be adapted to various modifications and supplementary functions.For example, can be via
User interface provides the chance toggled between the information for corresponding to first state and the second state is shown to prescription user.
As another example, all users change for cancelling aforementioned relative priority can be provided via user interface to prescription user
Change, and thus returns to using the original state relative priority between multiple clinical radiotherapy targets and about particular patient
The first chance for being presented multiple clinical radiotherapy targets based on the information of the radiation dose distribution of fluence.
Configured in this way, prescription user receives about in response to the relative prioritization between multiple clinical radiotherapy targets
The variation carried out by prescription user and the visual information of the variation of the dosage distributed intelligence based on fluence occurred, to show
Dosage corresponding to the order of priority between clinical radiotherapy target is weighed.
To it is described in detail below thoroughly examined and studied after, these and other benefit can become more clear
Chu.Referring now to the drawings, and with particular reference to Fig. 1, it will present now and instruct compatible illustrative device with many these
100。
In the illustrated examples, equipment 100 includes control circuit 101.As " circuit ", therefore control circuit 101 is wrapped
Structure is included, which includes at least one (and typically many) conductive path (such as by the conductive gold of such as copper or silver
Belong to the path constituted), conductive path transmits electric power in an orderly way, further includes the typical one corresponding electric component
It (is passive element (such as resistor and capacitor) and active component in due course (in such as various devices based on semiconductor
Any one) both) and with allow circuit realize these introduction control in terms of.
Such control circuit 101 may include that fixed-purpose hardwired hardware platform is (including but not limited to dedicated integrated
Circuit (ASIC) (it is by the integrated circuit of the design customization for special-purpose, without being intended for general-use),
Field programmable gate array (FPGA) etc.), or may include partially or even wholly programmable hardware platform it is (including but unlimited
In microcontroller, microprocessor etc.).These frameworks selection of these structures is well known in the art and understanding, and
Here it does not need to further describe.The control circuit 101 is configured (for example, will very by using such as those skilled in the art
The corresponding programming understood well) it is to execute one or more steps, movement and/or function as described herein.
By a kind of optional approach, control circuit 101 is operatively coupled to memory 102.The memory 102 can be with
Control circuit 101 is integral, or can according to need and be physically separated (all or part) with control circuit 101.The memory
102 can also be relative to control circuit 101 it is local (wherein both for example share common circuit board, chassis, power supply and/or
Shell), or can be relative to control circuit 101 it is partially or even wholly long-range (wherein for example with 101 phase of control circuit
Than memory 102 is physically located at another facility, metropolitan area or even national).
Other than first group of rule as described herein and second group of rule and other data, which may be used also
For example for non-transitory to store computer instruction, which causes to control when being executed by control circuit 101
Circuit 101 shows as described herein.(as used herein, this reference to " non-transitory " will be understood to is that
Refer to the non-transient state (and therefore exclusion when the content stored merely comprises signal or wave) of stored content rather than
The volatibility of storage medium itself, and therefore include nonvolatile memory (such as read-only memory (ROM) and volatibility
Memory (both such as Erasable Programmable Read Only Memory EPROMs (EPROM)).
Control circuit 101 is operatively coupled to user interface 103.The user interface 103 may include that various users are defeated
Enter mechanism (such as, but not limited to keyboard and keypad, cursor control device, touch-sensitive display, speech recognition interface, gesture identification
Interface etc.) and/or user export mechanism (such as, but not limited to visual displays, audio sensor, printer etc.) in it is any
One kind, in order to receive information and/or instruction from user and/or provide a user information.For purposes of this description, it is assumed that with
Family interface 103 includes at least touch-screen display.
If desired, control circuit 101 can be operatively coupled to network interface 104.Configured in this way, control circuit
101 can be via network interface 104 and other elements (in equipment 100 and outside it) communication.Including wireless and non-nothing
The network interface of both line platforms is not in the art it is well understood that and need particularly to be described in detail here.
Control circuit 101 optionally operationally can also (either directly or indirectly) be coupled to radiotherapy platform 105,
The radiotherapy platform 105 is configured to be delivered to therapeutic radiation according to the radiotherapy treatment planning optimized as described herein
Corresponding patient.
In typical application settings, radiotherapy platform 105 will include x-ray source (for example, linear based on radio frequency (RF)
(based on linear accelerator) x-ray source of particle accelerator, such as Varian Linatron M9).Linear accelerator is one
The particle accelerator of seed type is greatly increased by making charged particle be subjected to a series of oscillatory potential along linear bunch
Add the kinetic energy of electrification subatomic particle or ion, oscillatory potential can be used for generating ionizing radiation (for example, X-ray) and high energy electricity
Son.
Typical radiotherapy platform 105 can also include for the one or more in treatment ession for telecommunication support patient
Support surface (such as examination platform), selectivity mobile (along such as curved path) for allowing x-ray source rack or its
Its mechanism, the computer for optimizing radiotherapy treatment planning, and for providing selective beam shaping and/or beam tune as needed
One or more components (jaw, multi-diaphragm collimator (including single layer multi-diaphragm collimator and multilayer multi-diaphragm collimator) etc. of system.
Since aforementioned components and system are in the art it is well understood that therefore only related to description, otherwise here not
Being described in further detail in terms of these is provided.
Referring now to Fig. 2 (and continuing to refer to figure 1), the finger for being used to form the radiotherapy for being used for particular patient will be presented
The process 200 of fixed treatment instruction.For purposes of this description, it will be assumed that above-mentioned control circuit 101 executes in the process 200
Various steps, movement and the function of description.
It should be appreciated that specified treatment instruction is configurable for determining corresponding radiotherapy treatment planning optimization purpose, institute
Optimization purpose is stated to be subsequently used for creating the radiotherapy meter of optimization using the radiotherapy treatment planning optimisation technique of automatically iteration
It draws.For the sake of clarity, and as the skilled person will be well understood, specified treatment instruction and optimization purpose
It is different.But specified treatment instruction provides basis and the other information (letter such as, but not limited to about physical application setting
Breath), for determining corresponding radiotherapy treatment planning optimization purpose.
At frame 201, which provides user interface, such as above-mentioned user interface 103.
At frame 202, multiple clinical radiotherapy targets, multiple radiation are presented in control circuit 101 in user interface 103
Treating clinical target between them has the original state relative priority established by prescription user.In particular, prescription user
Both it can choose target itself, also can choose their relative priority.What Fig. 3 provided in these areas illustrative shows
Example.In this example, at least three clinical targets (being indicated by appended drawing reference 301 to 303) is presented in user interface 103.
In this example, each of these clinical targets are by corresponding identifier (by general identifier in Fig. 3
" identifier 1 ", " identifier 2 " and " identifier 3 " indicates) carry out the specific part of identified patient's body.In given application setting
Depending on the unique identifier used can according to need.The illustrated examples of this identifier include but is not limited to " brain ", " brain
It is dry ", " left ear ", " right middle ear ", " right eye ", " left eye ", " left view nerve ", " right optic nerve ", " intersection ", " spinal cord " etc..
In this example, (that is, one on the other side) is presented with the sequence that presents for clinical radiotherapy target.This is in
Each of now sequentially correspond to and set clinical radiotherapy target relative priority relative to each other.Particularly, exist
In the example, it is relatively low that the higher relative position of any given clinical target shows that relatively high priority correspondence is positioned to
Clinical target.
In this example, the presentation of each clinical radiotherapy target includes graph measures 304.The graph measures 304 1
As indicate a possibility that realizing the given dose target of corresponding identification division.By a kind of method, graph measures 304 it is most left
Side can be green, and the rightmost side of graph measures 304 can be red.If desired, central part can be coloured differently,
Such as use yellow.
In each case, triangle 305 is for show should be in the specific measurement of unique identifier.It is simply illustrative at this
In example, for first object 301 and the second target 302, which is located at the leftmost side of graph measures 304.The position
Show probably to meet corresponding target.However, triangle 305 is located at the position at more center for third target 303, and
And therefore show that there are rooms for improvement.If triangle 305 will further to the right, this, which will indicate that, is unlikely to meet correspondence
In the clinical target of special pattern measurement 304.
In this example, each of clinical target further includes protection icon 306.In this example, icon 306 is protected
It indicates any one of two kinds of possible states, and is also represented by the chance that user switches between both possible states.?
One state, and as shown in Figure 3, protects corresponding clinical target so that from make its corresponding realization based on fluence
Radiation dose distribution is reduced to some predeterminated level hereinafter, although user then changes (as described below) these clinical radiotherapies
Relative priority between target.(it in some cases, can provide a user and be easily modified the other tools of fluence/dosage
(such as drawing dosage or modification volume dose histogram figure line).If desired, aforementioned protection mechanism can be used for similarly mentioning
For protection in order to avoid all user actions influence and are not only relative priority.)
By clicking the specific one in these icons 306, state changes into the second state.In second state, as above
It is described no longer to protect corresponding clinical target, and so if user changes aforementioned relative priority (as described above, if needing
Want, including other changes based on user), then no longer protect realization based on the radiation dose distribution of fluence from potential
It significantly changes).It is desired.
Referring again to FIGS. 2, control circuit 101 obtains (for example, from aforementioned memory 102) first group of rule at frame 203
Then.First group of rule is according to the relative priority between multiple clinical radiotherapy targets and multiple clinical radiotherapy targets
To limit the radiation dose distribution based on fluence.Fluence will be understood to refer to the radiation flux integrated at any time, and wrap
Include the Elementary Measures (that is, measurement and calculating of the absorbed dose of the ionizing radiation in substance and tissue) in dosimetry.It constitutes
The particular kind of relationship of this function can change according to the needs that specific application is set.That is, for current purpose, fluence/
Standard, achievable treatment plan output is not necessarily represented on dosage is literal.On the contrary, provided herein simple in order to facilitate
Comparison result, fluence/dosage only need to imitate the compromise in the correctness of certain resonable degree, without being by really controlling
The true fluence or dosage that the plan for the treatment of generates.
At frame 204, control circuit 101 obtains second group of rule and (as needed, equally obtains from aforementioned memory 102
).Second group of rule is specified certainly according to the variation for detecting the relative priority between multiple clinical radiotherapy targets
It is saved dynamicly about the relative priority and the corresponding radiation based on fluence between aforesaid plurality of clinical radiotherapy target
The information of dosage distribution is as corresponding state.
At frame 205, control circuit 101 passes through relative to the aforementioned multiple clinical radiotherapy targets of first group of rule evaluation
Relative priority between multiple radiotherapy medical targets generates the first radiological dose based on fluence of particular patient
Distribution.At frame 206, then the first base about particular patient is presented in control circuit 101 via for example aforementioned user interface 103
In the information of the radiation dose distribution of fluence.For example, 304 can be measured via former figures for each of clinical target
Convey the information.
At frame 207, control circuit 101 is automatically saved about the relative priority between multiple clinical radiotherapy targets
The information of corresponding first radiation dose distribution based on fluence of grade and particular patient is as corresponding first state.Pass through one
Kind method, the first state information saved includes fluence information, but does not include corresponding calculated dosage distribution results.Such as
This configuration, prescription user (such as doctor), which can easily check and understand in a general sense, is formulating and is optimizing corresponding put
The degree of each of clinical target can be able to satisfy when penetrating treatment plan.
Referring now to Figure 4, the process 200 will be continued to describe.
At optional frame 401, control circuit 101 sexually revises via user interface 103 to prescription user offer selection more
The chance of relative priority between a clinical radiotherapy target.Such as pointed out above for the description of Fig. 3, in this example,
The relative priority of each clinical radiotherapy target is indicated according to the relative position of these targets relative to each other.Therefore,
In the illustrated examples, it includes selection and movement (for example, passing through click that selection, which sexually revises the aforementioned chance of the relative priority,
And dragging capabilities) at least one of clinical radiotherapy target relative position chance.
Fig. 5 provides simply illustrative example in these areas.In this example, prescription user selection and identifier 2
The target 302 is simultaneously dragged to 303 lower section of third clinical target by related second clinical target 302.In this example, control electricity
Road 101 rearranges clinical target automatically as needed to eliminate gap.After rearranging clinical target as described above,
First clinical target 301 has highest priority, followed by third clinical target 303 and tool now with the second high priority
There is the second clinical target 302 of third high priority.
In the illustrated examples of Fig. 5, still further it can be seen that, prescription user clicks the second clinical target 302 and third is faced
The protection icon 306 of bed target 303.Therefore, the result previously obtained is no longer protected in the above described manner.However, as described above,
One clinical target 301 nevertheless suffers from protection.
At the frame 402 of Fig. 4, control circuit detection the above-mentioned of clinical target rearrange, and identify clinical target it
Between relative priority corresponding variation.Change multiple clinical radiotherapy mesh at frame 403, and in response to prescription user
Relative priority between mark, control circuit 101 pass through relative to the aforementioned multiple clinical radiotherapy mesh of first group of rule evaluation
The relative priority of the change between multiple clinical radiotherapy targets is marked to generate the second of particular patient based on fluence
Radiation dose distribution.
At frame 404, the letter of the second radiation dose distribution based on fluence about particular patient is presented in control circuit 101
Breath.As shown in figure 5, the graph measures 304 for the second clinical target 302 are not so good as shown in Fig. 3 second state
First state it is advantageous, but be still advantageous.Meanwhile it is present for the graph measures of third clinical target 303 304
It is changed into more favorable state from unfavorable (or almost unfavorable) state.To sum up, prescription user can easily verify that change
General Influence of the original priority of clinical target to the ability for actually realizing desired target.
At frame 405, control circuit is automatically saved using second group of rule about multiple clinical radiotherapy targets
Between change relative priority and particular patient the corresponding second radiation dose distribution based on fluence information conduct
Corresponding second state.The information can be stored in for example above-mentioned memory 102.
If desired, the activity described in frame 401 to 405 can according to need repeatedly above, to obtain simultaneously
Storage indicates the additivity of other priority of clinical target.
At frame 406, control circuit 101, which is provided via user interface 103 to prescription user, is corresponding to above-mentioned first
The information of state and the second state show between the chance that toggles.This ability can be easily and intuitively to illustrate pair
The mode that should be weighed in the dosage of the priority between clinical radiotherapy target, which greatly simplifies, is presented the information.Such machine
It can may include that the user for example shown in user interface 103 can assert button.
At frame 407, which allows control circuit 101 to provide cancellation to prescription user via user interface 103 again
The chance of all users variation of relative priority between clinical target.Such chance also may include in user interface
The user shown on 103 can assert button.In response to selecting the chance, control circuit 101 be can be used between these targets
The information of original state relative priority and the first radiation dose distribution based on fluence about particular patient is come automatically
Multiple clinical radiotherapy targets are presented.
These introductions provide simple and effective mode to help prescription user to observe multiple clinical radiotherapy targets
Between the variation of relative priority how to cause to be expressed as the corresponding dosage tradeoff of the radiation dose distribution based on fluence.At
It hardly needs to function to be trained prescription user and be especially using these introductions and not need for setting optimization purpose institute
The subtle technology difference being related to carries out any deep training.Meanwhile by allowing prescription user to test and modify their clinic
The relative priority of target is provided for optimisation technique personnel, dosimetrist, medical physicist and clinic by prescription user
The dose prescription that doctor uses more likely provide radiotherapy treatment planning optimization purpose can based on useful input.
Those skilled in the art will recognize that without departing from the scope of the invention, it can be to above-mentioned implementation
Scheme makes various modifications, change and combination.As an example of this aspect, control circuit be can be configured as using user
Interface with allow prescription user optionally save any state and later selectivity back to saving state desired by them.Cause
This, these modifications, change and combination will be considered as in the range of inventive concept.
Claims (20)
1. a kind of for formulating the method for being used for patient's treatment prescription of radiotherapy and instructing, specified treatment instruction is configured
For the corresponding radiotherapy treatment planning optimization purpose for determining the radiotherapy treatment planning for creating optimization, the method packet
It includes:
User interface is provided；
Be presented multiple clinical radiotherapy targets in the user interface, the multiple clinical radiotherapy target at them it
Between have original state relative priority；
According to the original state between the multiple clinical radiotherapy target and the multiple clinical radiotherapy target
Relative priority determines the first radiation dose distribution based on fluence for patient, and presents about being directed to the patient
The described first radiation dose distribution based on fluence information；
It automatically saves about the relative priority between the multiple clinical radiotherapy target and for the patient
Corresponding described first radiation dose distribution based on fluence information, as corresponding first state；
In response to changing the relative priority between the multiple clinical radiotherapy target via the user interface, according to
It is described relatively excellent according to being changed between the multiple clinical radiotherapy target and the multiple clinical radiotherapy target
First grade dynamically determines the second radiation dose distribution based on fluence for the patient, and presents about for described
The information of the described second radiation dose distribution based on fluence of patient；
It automatically saves about the relative priority changed between the multiple clinical radiotherapy target and is directed to
The information of corresponding described second radiation dose distribution based on fluence of particular patient, as corresponding second state；
It is shown in the user interface about in response to the relative priority between the multiple clinical radiotherapy target
The variation of sequence and the visual information of the variation to the dosage distributed intelligence based on fluence occurred, correspond to described put to show
Penetrate the dosage tradeoff of the order of priority between treatment clinical target.
2. the method as described in claim 1, wherein present in the user interface has relative priority between them
The multiple clinical radiotherapy target include: that the clinical radiotherapy target is presented with presentation sequence, wherein described
The relative position of a specific clinical radiotherapy target in clinical radiotherapy target is established to be faced for the radiotherapy
The relative priority of a specific clinical radiotherapy target in bed target.
3. method according to claim 2, further includes:
The relative priority between the multiple clinical radiotherapy target is sexually revised via user interface selection.
4. method as claimed in claim 3, wherein the selectivity changes between the multiple clinical radiotherapy target
The relative priority includes: at least one of selection and the mobile clinical radiotherapy target in the user interface
The relative position of clinical radiotherapy target.
5. method as claimed in claim 4, wherein the selection and movement include being clicking and dragging on the multiple radiotherapy
A clinical radiotherapy target in clinical target.
6. the method as described in claim 1, further includes:
It is toggled between the information for corresponding to the first state and second state is shown in the user interface.
7. the method as described in claim 1, further includes:
Cancel all changes to the relative priority via the user interface, and in response to this, use is the multiple
The original state relative priority between clinical radiotherapy target is together with about first base for being directed to the patient
The multiple clinical radiotherapy target is presented in the information of the radiation dose distribution of fluence.
8. the method as described in claim 1, wherein automatically saving about for the corresponding described based on note of the patient
The information of the radiation dose distribution of amount includes: storage fluence information without storing corresponding calculated dose as corresponding state
Measure distribution results.
9. the method as described in claim 1, wherein at least one radiotherapy in the multiple clinical radiotherapy target
Clinical target constitutes the target for being directed to treatment region, and at least one radiotherapy in the multiple clinical radiotherapy target
Clinical target is constituted for the target for jeopardizing organ.
10. the method as described in claim 1, further includes:
Regardless of the subsequent variation to the relative priority between the multiple clinical radiotherapy target, all via institute
State being realized for the clinical radiotherapy target that user interface protection corresponds in the multiple clinical radiotherapy target
The radiation dose distribution based on fluence.
11. a kind of for formulating the method for being used for the patient of radiotherapy and treating instruction, specified treatment instruction is configured
For for use automatically iteration radiotherapy treatment planning optimize determine for create optimize radiotherapy treatment planning correspondence
Radiotherapy treatment planning optimize purpose, which comprises
User interface is provided；
Be presented multiple clinical radiotherapy targets in the user interface, the multiple clinical radiotherapy target at them it
Between have original state relative priority；
First group of rule is obtained, first group of rule is controlled according to the multiple clinical radiotherapy target and the multiple radiation
The relative priority between clinical target is treated to limit the radiation dose distribution based on fluence；
Second group of rule is obtained, second group of rule foundation is detected to the institute between the multiple clinical radiotherapy target
It states the variation of relative priority and specifies and automatically save about the relative priority between the multiple clinical radiotherapy target
The information of grade and the corresponding radiation dose distribution based on fluence is as corresponding state；
By facing relative to the multiple clinical radiotherapy target of first group of rule evaluation and the multiple radiotherapy
The relative priority between bed target, to generate the first radiation dose distribution based on fluence for the patient；
The information about the described first radiation dose distribution based on fluence for the patient is presented；
It automatically saves about the relative priority between the multiple clinical radiotherapy target and for the patient
Corresponding described first radiation dose distribution based on fluence information as corresponding first state；
In response to changing the relative priority between the multiple clinical radiotherapy target via the user interface, lead to
It crosses relative to the multiple clinical radiotherapy target of first group of rule evaluation and the multiple clinical radiotherapy target
Between the relative priority changed generate the second radiation dose distribution based on fluence for the patient；
The information about the described second radiation dose distribution based on fluence for the patient is presented；
It is automatically saved using second group of rule about being changed between the multiple clinical radiotherapy target
The information conduct of the relative priority and corresponding described second radiation dose distribution based on fluence for the patient
Corresponding second state；
Display occurs about in response to the variation to the relative prioritization between the multiple clinical radiotherapy target
To the visual information of the variation of the dosage distributed intelligence based on fluence, thus show corresponding to the clinical radiotherapy target it
Between order of priority dosage tradeoff.
12. method as claimed in claim 11, wherein present in the user interface has relative priority between them
The multiple clinical radiotherapy target of grade includes: to be presented the clinical radiotherapy target with presentation sequence, wherein institute
The relative position for stating the specific clinical radiotherapy target in clinical radiotherapy target is established for the radiotherapy
The relative priority of a specific clinical radiotherapy target in clinical target.
13. method as claimed in claim 12, further includes:
Selection sexually revises the relative priority between the multiple clinical radiotherapy target.
14. method as claimed in claim 13, selection sexually revises the phase between the multiple clinical radiotherapy target
It include: at least one of to select in the user interface and move the clinical radiotherapy target radiation to control to priority
Treat the relative position of clinical target.
15. method as claimed in claim 14, wherein selection and movement include being clicking and dragging on the clinical radiotherapy mesh
A specific clinical radiotherapy target in mark.
16. method as claimed in claim 11, the method also includes:
It shows in the information for corresponding to the first state and is toggled between the display of second state.
17. method as claimed in claim 11, further includes:
Cancel all changes to the relative priority, and in response to this, uses the multiple clinical radiotherapy target
Between the original state relative priority together with about be directed to the patient the described first radiological dose based on fluence
The information of distribution is presented the multiple clinical radiotherapy target.
18. method as claimed in claim 11, described it is based on wherein automatically saving about for the corresponding of the patient
The information of the radiation dose distribution of fluence includes that storage fluence information is corresponding calculated without storing as corresponding state
Dosage distribution results.
19. method as claimed in claim 11, wherein the radiation of at least one of the multiple clinical radiotherapy target is controlled
It treats clinical target and constitutes the target for being directed to treatment region, and the radiation of at least one of the multiple clinical radiotherapy target is controlled
Clinical target is treated to constitute for the target for jeopardizing organ.
20. a kind of for formulating the equipment for being used for patient's treatment prescription of radiotherapy and instructing, the treatment prescription instruction is matched
It is set to the corresponding radiotherapy treatment planning for determining the radiotherapy treatment planning for creating optimization and optimizes purpose, the equipment packet
It includes:
User interface；
Control unit, described control unit are operatively coupled to the user interface and are configured as:
Multiple clinical radiotherapy targets are presented in the user interface, the multiple clinical radiotherapy target is at them
Between have original state relative priority；
According to the relative priority between the multiple clinical radiotherapy target and the multiple clinical radiotherapy target
Grade determines the first radiation dose distribution based on fluence for the patient, and presents about the institute for being directed to the patient
State the information of the first radiation dose distribution based on fluence；
It automatically saves about the relative priority between the multiple clinical radiotherapy target and for the patient
Corresponding described first radiation dose distribution based on fluence information as corresponding first state；
According to the relatively excellent of the change between the multiple clinical radiotherapy target and the multiple clinical radiotherapy target
First grade dynamically determines the second radiation dose distribution based on fluence for the patient, and presents about for described
The information of the described second radiation dose distribution based on fluence of patient；
It automatically saves about the relative priority of the change between the multiple clinical radiotherapy target and for institute
The information of corresponding described second radiation dose distribution based on fluence of patient is stated as corresponding second state；
Display occurs about in response to the variation to the relative prioritization between the multiple clinical radiotherapy target
To the visual information of the variation of the dosage distributed intelligence based on fluence, thus show corresponding to the clinical radiotherapy target it
Between order of priority dosage tradeoff.
Applications Claiming Priority (2)
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| US15/941,293 | 2018-03-30 | ||
| US15/941,293 US11964169B2 (en) | 2018-03-30 | 2018-03-30 | Apparatus and method for forming prescribed radiation therapy treatment instructions |
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| US12011613B2 (en) | 2019-09-09 | 2024-06-18 | Siemens Healthineers International Ag | Systems and methods for automatic treatment planning and optimization |
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| EP3546023A1 (en) | 2019-10-02 |
| US11964169B2 (en) | 2024-04-23 |
| EP3546023B1 (en) | 2021-01-13 |
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