CN110240137A - A kind of preparation method of nano hydroxyapatite powder - Google Patents
A kind of preparation method of nano hydroxyapatite powder Download PDFInfo
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- CN110240137A CN110240137A CN201910328004.5A CN201910328004A CN110240137A CN 110240137 A CN110240137 A CN 110240137A CN 201910328004 A CN201910328004 A CN 201910328004A CN 110240137 A CN110240137 A CN 110240137A
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- hydroxyapatite powder
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- nano hydroxyapatite
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- ionic calcium
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- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 title claims abstract description 43
- 238000002360 preparation method Methods 0.000 title claims abstract description 23
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims abstract description 29
- 239000011575 calcium Substances 0.000 claims abstract description 29
- 229910052791 calcium Inorganic materials 0.000 claims abstract description 29
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 claims abstract description 28
- 229910052588 hydroxylapatite Inorganic materials 0.000 claims abstract description 27
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims abstract description 15
- 238000001556 precipitation Methods 0.000 claims abstract description 15
- 238000005507 spraying Methods 0.000 claims abstract description 15
- 238000002604 ultrasonography Methods 0.000 claims abstract description 10
- 238000004108 freeze drying Methods 0.000 claims abstract description 3
- 235000011114 ammonium hydroxide Nutrition 0.000 claims description 9
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 claims description 8
- 241000186216 Corynebacterium Species 0.000 claims description 6
- 229910000147 aluminium phosphate Inorganic materials 0.000 claims description 4
- 150000005837 radical ions Chemical class 0.000 claims description 4
- ZQBZAOZWBKABNC-UHFFFAOYSA-N [P].[Ca] Chemical compound [P].[Ca] ZQBZAOZWBKABNC-UHFFFAOYSA-N 0.000 claims description 2
- 238000000034 method Methods 0.000 abstract description 24
- 230000000149 penetrating effect Effects 0.000 abstract description 4
- 239000000243 solution Substances 0.000 description 15
- 238000006243 chemical reaction Methods 0.000 description 10
- 239000007788 liquid Substances 0.000 description 7
- 230000008569 process Effects 0.000 description 7
- 230000015572 biosynthetic process Effects 0.000 description 5
- 239000000843 powder Substances 0.000 description 5
- 238000009388 chemical precipitation Methods 0.000 description 4
- 238000003786 synthesis reaction Methods 0.000 description 4
- 238000005406 washing Methods 0.000 description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
- 229910019142 PO4 Inorganic materials 0.000 description 3
- 238000005119 centrifugation Methods 0.000 description 3
- 229960000935 dehydrated alcohol Drugs 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 238000007710 freezing Methods 0.000 description 3
- 230000008014 freezing Effects 0.000 description 3
- 239000011259 mixed solution Substances 0.000 description 3
- 239000011858 nanopowder Substances 0.000 description 3
- 239000010452 phosphate Substances 0.000 description 3
- -1 phosphate anion Chemical class 0.000 description 3
- 229910021642 ultra pure water Inorganic materials 0.000 description 3
- 239000012498 ultrapure water Substances 0.000 description 3
- 230000002776 aggregation Effects 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 210000000988 bone and bone Anatomy 0.000 description 2
- 239000000919 ceramic Substances 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 230000012010 growth Effects 0.000 description 2
- 230000006872 improvement Effects 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 230000006911 nucleation Effects 0.000 description 2
- 238000010899 nucleation Methods 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 230000001376 precipitating effect Effects 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 description 1
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 238000005054 agglomeration Methods 0.000 description 1
- 238000004220 aggregation Methods 0.000 description 1
- 239000000908 ammonium hydroxide Substances 0.000 description 1
- 229910052586 apatite Inorganic materials 0.000 description 1
- 239000003462 bioceramic Substances 0.000 description 1
- 230000008468 bone growth Effects 0.000 description 1
- 238000001354 calcination Methods 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000000227 grinding Methods 0.000 description 1
- 238000001027 hydrothermal synthesis Methods 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 230000000977 initiatory effect Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000000593 microemulsion method Methods 0.000 description 1
- 239000003595 mist Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- VSIIXMUUUJUKCM-UHFFFAOYSA-D pentacalcium;fluoride;triphosphate Chemical compound [F-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O VSIIXMUUUJUKCM-UHFFFAOYSA-D 0.000 description 1
- 239000011574 phosphorus Substances 0.000 description 1
- 229910052698 phosphorus Inorganic materials 0.000 description 1
- 230000000644 propagated effect Effects 0.000 description 1
- 239000000376 reactant Substances 0.000 description 1
- 230000035484 reaction time Effects 0.000 description 1
- 230000008439 repair process Effects 0.000 description 1
- 238000003980 solgel method Methods 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000004575 stone Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000001360 synchronised effect Effects 0.000 description 1
- 230000002194 synthesizing effect Effects 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 238000002525 ultrasonication Methods 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y40/00—Manufacture or treatment of nanostructures
-
- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01B—NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
- C01B25/00—Phosphorus; Compounds thereof
- C01B25/16—Oxyacids of phosphorus; Salts thereof
- C01B25/26—Phosphates
- C01B25/32—Phosphates of magnesium, calcium, strontium, or barium
-
- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01P—INDEXING SCHEME RELATING TO STRUCTURAL AND PHYSICAL ASPECTS OF SOLID INORGANIC COMPOUNDS
- C01P2004/00—Particle morphology
- C01P2004/10—Particle morphology extending in one dimension, e.g. needle-like
-
- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01P—INDEXING SCHEME RELATING TO STRUCTURAL AND PHYSICAL ASPECTS OF SOLID INORGANIC COMPOUNDS
- C01P2004/00—Particle morphology
- C01P2004/10—Particle morphology extending in one dimension, e.g. needle-like
- C01P2004/16—Nanowires or nanorods, i.e. solid nanofibres with two nearly equal dimensions between 1-100 nanometer
-
- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01P—INDEXING SCHEME RELATING TO STRUCTURAL AND PHYSICAL ASPECTS OF SOLID INORGANIC COMPOUNDS
- C01P2004/00—Particle morphology
- C01P2004/60—Particles characterised by their size
- C01P2004/64—Nanometer sized, i.e. from 1-100 nanometer
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- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Nanotechnology (AREA)
- General Physics & Mathematics (AREA)
- Manufacturing & Machinery (AREA)
- Crystallography & Structural Chemistry (AREA)
- Physics & Mathematics (AREA)
- Inorganic Chemistry (AREA)
- Condensed Matter Physics & Semiconductors (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- Materials For Medical Uses (AREA)
- Medicinal Preparation (AREA)
Abstract
The present invention provides a kind of preparation method of nano hydroxyapatite powder, 1) preparation method is the following steps are included: configure phosphate anion solution, and adjust the pH value of the phosphate anion solution to 10-12；2) ionic calcium soln is configured, and adjusts the pH value of the ionic calcium soln to 10-12；3) it is placed in the phosphate anion solution of ultrasound environments after being atomized the ionic calcium soln by ullrasonic spraying with certain flow rate penetrating, then, stands, obtain precipitation of hydroxyapatite；4) precipitation of hydroxyapatite is washed, then, freeze-drying obtains nano hydroxyapatite powder.The present invention synthesizes that partial size is small and uniform hydroxyapatite nano-powder using supersonic spraying combination conventional ultrasound method in higher concentration and under room temperature.
Description
Technical field
The present invention relates to nano-powder preparation technical field, in particular to a kind of preparation side of nano hydroxyapatite powder
Method.
Background technique
Hydroxyapatite (HAP) is the highest inorganic constituent of content in skeleton, this kind of material has good
Bioactivity and biocompatibility, HAP bioceramic can be a kind of energy with the very strong chemical combination key of bon e formation after being implanted into human body
Enough excellent materials to substitute skeleton, and there is good bone conduction effect, play the role of inducing new bone growth.But
The mechanical property of hydroxylapatite ceramic is bad, and lower mechanical strength is the key that restrict it to play a role in terms of bone repair
Point.Studies have shown that the Some Mechanical Properties of the HAP ceramics of synthesis have improvement when hydroxyapatite powder reaches nanoscale.Cause
This, the preparation of nano-HAP powder is present main direction of studying.
The method for preparing nanometer hydroxyapatite is broadly divided into dry method (solid reaction process) and wet process (solution reaction method).By
It is larger in the hydroxy apatite powder partial size that dry process goes out, and since long-time mix grinding raw material causes raw material easy to be dirty
Dye, and wet method equipment demand is simple, and obtained diameter of particle is small and uniform, therefore generally use wet process.Wet process has: hydro-thermal
Method, chemical precipitation method, microemulsion method, sol-gel method etc..Due to wanting industrialized production nanometer hydroxyapatite, need to control
Cost, it is easy to operate, therefore this prior synthesizing method of chemical precipitation method is widely used.Chemical precipitation method is to prepare nano-HAP
The conventional method of powder has required experiment condition lower, and the process of reaction is easily controlled, the very low advantage of cost, the party
Method is that phosphorus source and calcium source are mixed stirring, then adjusts pH with ammonium hydroxide, and then generates HAP precipitating, then by standing, washing
It washs, after drying and other steps, by powder calcination, so that HAP crystal is obtained, but the nano-hydroxy-apatite that chemical precipitation method is prepared
For stone powder reuniting situation than more serious, uniformity is poor.
Summary of the invention
In view of this, the present invention is directed to propose a kind of preparation method of nano hydroxyapatite powder, to solve existing hydroxyl
The problem of base apatite powder partial size is big, particle diameter distribution is uneven and preparation process is easy to appear reunion.
In order to achieve the above objectives, the technical scheme of the present invention is realized as follows:
A kind of preparation method of nano hydroxyapatite powder, comprising the following steps:
1) phosphate anion solution is prepared, and adjusts the pH value of the phosphate anion solution to 10-12；
2) ionic calcium soln is prepared, and adjusts the pH value of the ionic calcium soln to 10-12；
3) it is placed in described in ultrasound environments after being atomized the ionic calcium soln by ullrasonic spraying with certain flow rate penetrating
In phosphate anion solution, then, stands, obtain precipitation of hydroxyapatite；
4) precipitation of hydroxyapatite is washed, then, freeze-drying obtains nano hydroxyapatite powder.
Optionally, the concentration of phosphate anion solution described in the step 1) is 0.12mol/L-0.3mol/L, and institute
The calcium-phosphorus ratio for stating ionic calcium soln described in phosphate anion solution and the step 2) is 1.67.
Optionally, the step 1) and solution used in adjusting pH value in the step 2) are concentrated ammonia liquor.
Optionally, the ullrasonic spraying nebulisation time of ionic calcium soln described in the step 3) is 5min-20min.
Optionally, flow velocity described in the step 3) is 2ml/min-8ml/min.
Optionally, nano hydroxyapatite powder described in the step 4) be needle-shaped and corynebacterium, and it is described it is needle-shaped and
It is 60-120nm that the nano hydroxyapatite powder of corynebacterium, which obtains length,.
Optionally, the average grain diameter of nano hydroxyapatite powder described in the step 4) is 70-90nm.
Compared with the existing technology, the preparation method of nano hydroxyapatite powder of the present invention has the advantage that
1, the preparation method of nano hydroxyapatite powder of the invention first uses the method for ullrasonic spraying by reaction solution
Become liquid droplet, increased considerably the contact area of reactant, so as to dramatically increase nucleation density, promote nucleus
It is formed and is grown, while there is the mist drop of large energy to also play positive facilitation to the nucleation of HAP phase and growth,
It recycles conventional ultrasound to synthesize nanometer hydroxyapatite, by ultrasonic cavitation, improves the energy of synthetic environment, and by
Cause strong stirring action in the whirling motion of cavitation bubble, eliminate local non-uniform phenomenon, controls the synchronous growth of nucleus, together
When, cavitation also substantially reduces the specific surface energy of nucleus, it is suppressed that the aggregation of nucleus with grow up, and also due to crush make
With precipitating has been smashed, the uniformity of the nano hydroxyapatite powder of synthesis is improved, reunion is improved.
2, the present invention substantially reduces the entire reaction time of synthesis nano hydroxyapatite powder, reduces higher concentration
Under agglomeration traits, and crystallinity is also promoted.
3, the preparation process of nano hydroxyapatite powder of the present invention is simple, easy to operate, whole process reaction condition temperature
With do not need high temperature high pressure process.
Detailed description of the invention
The attached drawing for constituting a part of the invention is used to provide further understanding of the present invention, schematic reality of the invention
It applies example and its explanation is used to explain the present invention, do not constitute improper limitations of the present invention.In the accompanying drawings:
Fig. 1 is 50k times of Scanning Electron microscope (SEM) of nano hydroxyapatite powder prepared by the embodiment of the present invention 1
Photo；
Fig. 2 is 100k times of Scanning Electron microscope (SEM) of nano hydroxyapatite powder prepared by the embodiment of the present invention 2
Photo；
Fig. 3 is 100k times of Scanning Electron microscope (SEM) of nano hydroxyapatite powder prepared by the embodiment of the present invention 3
Photo.
Specific embodiment
It is to accelerate and control chemical reaction by ultrasonic cavitation energy that ultrasonic method, which prepares nano-powder, promotes the yield of reaction
The new chemical reaction with initiation, wherein conventional ultrasound method is that ultrasonic wave is propagated around by liquid medium, is reaching certain energy
When, ultrasonic cavitation can occur for liquid medium, accelerate heat transfer and mass transport process between interface, improve the synthesis speed of chemical reaction
Rate and yield.
Supersonic spraying is to be converted one of solution to one surely by ultrasonic cavitation energy by ultrasonication
The misty liquid droplets of amount are sprayed into another reaction solution and are synthesized, due to misty liquid droplets have the characteristics that uniformly it is tiny, and have
There is energy, therefore may synthesize and obtain uniformly tiny nano-powder, which is from inlet when ultrasonic wave through being transmitted to
Up to liquid outlet solution surface when, liquid-gas interface ie in solution surface and air interface are in be surpassed by perpendicular to interface
After the effect of sound wave, due to the effect of ultrasonic wave, solution surface is made to form tensile wave, with the enhancing of surface tension wave energy,
When surface tension wave energy reaches certain value, also increase the liquid made at its wave crest simultaneously in the tensile wave wave crest of solution surface
Droplet flies out.
The present invention is based on this, is synthesized using supersonic spraying combination conventional ultrasound method in higher concentration and under room temperature
Partial size is small and uniform hydroxyapatite nano-powder.
It should be noted that in the absence of conflict, the feature in embodiment and embodiment in the present invention can phase
Mutually combination.
Below in conjunction with drawings and examples, the present invention will be described in detail.
Embodiment 1
A kind of preparation method of nano hydroxyapatite powder, comprising the following steps:
1) the phosphate anion solution that 160ml concentration is 0.12mol/L is prepared, and phosphate anion is adjusted using concentrated ammonia liquor
The pH value of solution is to 10；
2) ionic calcium soln that 40ml concentration is 0.2004mol/L is prepared, and ionic calcium soln is adjusted using concentrated ammonia liquor
PH value is to 10；
3) phosphoric acid for being placed in ultrasound environments is sprayed into after being atomized ionic calcium soln by ullrasonic spraying with the flow velocity of 2ml/min
In radical ion solution, wherein the ullrasonic spraying nebulisation time of ionic calcium soln is 20min, has been sprayed into whole ionic calcium solns
Mixed solution is stood half an hour, obtains precipitation of hydroxyapatite by Bi Hou；
4) precipitation of hydroxyapatite is poured into centrifuge tube, repeatedly washing is using ultrapure water and dehydrated alcohol and by centrifugation
Neutrality, then by after the precipitation of hydroxyapatite freezing for 24 hours of washes clean, be placed in freeze drier dry 12h, obtain white
Nano hydroxyapatite powder.
Embodiment 2
A kind of preparation method of nano hydroxyapatite powder, comprising the following steps:
1) the phosphate anion solution that configuration 160ml concentration is 0.12mol/L, and phosphate anion is adjusted using concentrated ammonia liquor
The pH value of solution is to 10；
2) ionic calcium soln that configuration 40ml concentration is 0.2004mol/L, and ionic calcium soln is adjusted using concentrated ammonia liquor
PH value is to 10；
3) phosphoric acid for being placed in ultrasound environments is sprayed into after being atomized ionic calcium soln by ullrasonic spraying with the flow velocity of 8ml/min
In radical ion solution, wherein the ullrasonic spraying nebulisation time of ionic calcium soln is 5min, is finished to the penetrating of whole ionic calcium solns
Afterwards, mixed solution is stood into half an hour, obtains precipitation of hydroxyapatite；
4) precipitation of hydroxyapatite is poured into centrifuge tube, repeatedly washing is using ultrapure water and dehydrated alcohol and by centrifugation
Neutrality, then by after the precipitation of hydroxyapatite freezing for 24 hours of washes clean, be placed in freeze drier dry 12h, obtain white
Nano hydroxyapatite powder.
Embodiment 3
A kind of preparation method of nano hydroxyapatite powder, comprising the following steps:
1) the phosphate anion solution that configuration 160ml concentration is 0.3mol/L, and phosphate anion is adjusted using concentrated ammonia liquor
The pH value of solution is to 10；
2) ionic calcium soln that configuration 40ml concentration is 0.501mol/L, and using the pH of concentrated ammonia liquor adjusting ionic calcium soln
It is worth to 10；
3) phosphoric acid for being placed in ultrasound environments is sprayed into after being atomized ionic calcium soln by ullrasonic spraying with the flow velocity of 8ml/min
In radical ion solution, wherein the ullrasonic spraying nebulisation time of ionic calcium soln is 5min, is finished to the penetrating of whole ionic calcium solns
Afterwards, mixed solution is stood into half an hour, obtains precipitation of hydroxyapatite；
4) precipitation of hydroxyapatite is poured into centrifuge tube, repeatedly washing is using ultrapure water and dehydrated alcohol and by centrifugation
Neutrality, then by after the precipitation of hydroxyapatite freezing for 24 hours of washes clean, be placed in freeze drier dry 12h, obtain white
Nano hydroxyapatite powder.
Pattern test carried out to the nano hydroxyapatite powder of 1~embodiment of embodiment 3, test result respectively as Fig. 1,
Shown in Fig. 2 and Fig. 3.
By Fig. 1, Fig. 2 and Fig. 3 it is found that the nano hydroxyapatite powder of 1~embodiment of the embodiment of the present invention 3 be it is needle-shaped and
Corynebacterium, and the length of needle-shaped and corynebacterium nano hydroxyapatite powder is 60-120nm.
The fineness of the nano hydroxyapatite powder of 1~embodiment of embodiment 3 is tested.
After tested it is found that the average grain diameter of the nano hydroxyapatite powder of 1~embodiment of the embodiment of the present invention 3 is 70-
90nm。
The above is merely preferred embodiments of the present invention, be not intended to limit the invention, it is all in spirit of the invention and
Within principle, any modification, equivalent replacement, improvement and so on be should all be included in the protection scope of the present invention.
Claims (7)
1. a kind of preparation method of nano hydroxyapatite powder, which comprises the following steps:
1) phosphate anion solution is prepared, and adjusts the pH value of the phosphate anion solution to 10-12；
2) ionic calcium soln is prepared, and adjusts the pH value of the ionic calcium soln to 10-12；
3) phosphoric acid for being placed in ultrasound environments is sprayed into after being atomized the ionic calcium soln by ullrasonic spraying with certain flow rate
In radical ion solution, then, stands, obtain precipitation of hydroxyapatite；
4) precipitation of hydroxyapatite is washed, then, freeze-drying obtains nano hydroxyapatite powder.
2. the preparation method of nano hydroxyapatite powder according to claim 1, which is characterized in that in the step 1)
The concentration of the phosphate anion solution is 0.12mol/L-0.3mol/L, and the phosphate anion solution and the step 2)
Described in ionic calcium soln calcium-phosphorus ratio be 1.67.
3. the preparation method of nano hydroxyapatite powder according to claim 1, which is characterized in that the step 1) and
It is concentrated ammonia liquor that solution used in pH value is adjusted in the step 2).
4. the preparation method of nano hydroxyapatite powder according to claim 1, which is characterized in that in the step 3)
The ullrasonic spraying nebulisation time of the ionic calcium soln is 5min-20min.
5. the preparation method of nano hydroxyapatite powder according to claim 1, which is characterized in that in the step 3)
The flow velocity is 2ml/min-8ml/min.
6. the preparation method of nano hydroxyapatite powder according to claim 1, which is characterized in that in the step 4)
The nano hydroxyapatite powder is needle-shaped and corynebacterium, and described needle-shaped and corynebacterium nano hydroxyapatite powder obtains
Length is 60-120nm.
7. the preparation method of nano hydroxyapatite powder according to claim 1, which is characterized in that in the step 4)
The average grain diameter of the nano hydroxyapatite powder is 70-90nm.
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112195026A (en) * | 2020-10-14 | 2021-01-08 | 武汉理工大学 | Europium-doped beta-tricalcium phosphate fluorescent nano-particles and preparation method and application thereof |
| CN112195026B (en) * | 2020-10-14 | 2022-12-23 | 武汉理工大学 | Europium-doped beta-tricalcium phosphate fluorescent nano-particles and preparation method and application thereof |
| CN112978695A (en) * | 2021-03-16 | 2021-06-18 | 华东理工大学 | Preparation method of bionic hydroxyapatite nanoparticles with high osteogenic activity |
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