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CN110168098A - 一种检测糖代谢异常的方法及其预防及治疗 - Google Patents

一种检测糖代谢异常的方法及其预防及治疗 Download PDF

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Publication number
CN110168098A
CN110168098A CN201680090803.8A CN201680090803A CN110168098A CN 110168098 A CN110168098 A CN 110168098A CN 201680090803 A CN201680090803 A CN 201680090803A CN 110168098 A CN110168098 A CN 110168098A
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gpx2
individual
expression
expression quantity
mouse
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Inventor
余明隆
庄万龙
黄志富
戴嘉言
柯佑民
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Kaohsiung Medical University
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Kaohsiung Medical University
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Abstract

本发明是有关于一种检测糖类代谢异常的方法，包括检测检体中GPx2基因表达、GPx2蛋白表达量、或GPx2的蛋白活性，并与一正常个体的GPx2表达量进行比较，其中该个体的GPx2表达量显著低于该正常个体的GPx2表达量代表该个体具有糖类代谢异常的状态。本发明另提供一种GPx2用于制备治疗预防第二型糖尿病的医药组合物的用途。

Description

PCT国内申请，说明书已公开。

Claims (8)

  1. PCT国内申请，权利要求书已公开。
CN201680090803.8A 2016-11-14 2016-11-14 一种检测糖代谢异常的方法及其预防及治疗 Pending CN110168098A (zh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/CN2016/105759 WO2018086126A1 (zh) 2016-11-14 2016-11-14 一种检测糖代谢异常的方法及其预防及治疗

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CN110168098A true CN110168098A (zh) 2019-08-23

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Country Link
US (1) US11439689B2 (zh)
EP (1) EP3540072A4 (zh)
JP (1) JP7066209B2 (zh)
KR (1) KR20190077037A (zh)
CN (1) CN110168098A (zh)
WO (1) WO2018086126A1 (zh)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103470194B (zh) * 2013-09-07 2015-12-23 中国石油集团西部钻探工程有限公司 易上卸套管母扣护丝装置

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005046718A1 (en) * 2003-11-06 2005-05-26 Ohio University Diagnosis and hyperinsulinemia and type ii diabetes and protection against same based on genes differentially expressed in pancreas cells (12.1)
WO2005058142A2 (en) * 2003-12-16 2005-06-30 Emory University Diabetes diagnostic
WO2006056080A1 (en) * 2004-11-29 2006-06-01 Diagnocure Inc. Gpx2 a specific and sensitive target for lung cancer diagnosis, prognosis and/or theranosis
WO2010005533A2 (en) * 2008-06-30 2010-01-14 The Johns Hopkins University Compositions and methods for the treatment of ocular oxidative stress and retinitis pigmentosa
CN104651329A (zh) * 2014-02-18 2015-05-27 吉林大学 一种含有丝氨酸的谷胱甘肽过氧化物酶gpx2突变体及其制备方法
WO2016057574A1 (en) * 2014-10-06 2016-04-14 Memorial Sloan-Kettering Cancer Center Method to reduce oncogenic potential of induced pluripotent stem cells from aged donors

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1256312A (zh) * 1998-10-29 2000-06-14 复旦大学 新的人谷胱苷肽过氧化酶、其编码序列及制法和用途
NZ580169A (en) 2003-10-23 2011-04-29 Illumigen Biosciences Inc Detection of mutations in a gene associated with resistance to viral infection, OAS1 (SEQ ID NO:48)
NZ606888A (en) 2009-04-16 2014-07-25 Taisho Pharmaceutical Co Ltd Pharmaceutical compositions for the treatment of diabetes mellitus

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005046718A1 (en) * 2003-11-06 2005-05-26 Ohio University Diagnosis and hyperinsulinemia and type ii diabetes and protection against same based on genes differentially expressed in pancreas cells (12.1)
WO2005058142A2 (en) * 2003-12-16 2005-06-30 Emory University Diabetes diagnostic
WO2006056080A1 (en) * 2004-11-29 2006-06-01 Diagnocure Inc. Gpx2 a specific and sensitive target for lung cancer diagnosis, prognosis and/or theranosis
WO2010005533A2 (en) * 2008-06-30 2010-01-14 The Johns Hopkins University Compositions and methods for the treatment of ocular oxidative stress and retinitis pigmentosa
CN104651329A (zh) * 2014-02-18 2015-05-27 吉林大学 一种含有丝氨酸的谷胱甘肽过氧化物酶gpx2突变体及其制备方法
WO2016057574A1 (en) * 2014-10-06 2016-04-14 Memorial Sloan-Kettering Cancer Center Method to reduce oncogenic potential of induced pluripotent stem cells from aged donors

Also Published As

Publication number Publication date
WO2018086126A1 (zh) 2018-05-17
EP3540072A1 (en) 2019-09-18
US20200093897A1 (en) 2020-03-26
US11439689B2 (en) 2022-09-13
JP2020513232A (ja) 2020-05-14
EP3540072A4 (en) 2020-05-20
KR20190077037A (ko) 2019-07-02
JP7066209B2 (ja) 2022-05-13

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